IL34 Gene
protein-coding GIFtS: 49
GCID: GC16P070680
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interleukin 34(Previous name: chromosome 16 open reading frame 77 )
(Previous symbol: C16orf77)
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Aliases
for IL34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 341 2 | | C16orf771 2 3 5 | | IL-341 2 3 | | MGC346471 | | Chromosome 16 Open Reading Frame 771 | | Interleukin-341 |
Export aliases for IL34 gene to outside databasesPrevious GC identifers: GC16P069239 GC16P056451 |
Summaries
for IL34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL34:
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through thecolony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 (PubMed 18467591)).(supplied by OMIM, May2008)
UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4Function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotesthe release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatoryprocesses. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in theregulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation ofMAPK1/ERK2 AND MAPK3/ERK1
Gene Wiki entry for IL34 (Interleukin 34)
|
Genomic Views
for IL34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL34 gene promoter:
USF1 RFX1 Sp1 POU3F2 YY1 FOXL1 E47 AREB6 CP2 USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1IL34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P070680: view genomic region
(about GC identifiers)
Start:
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70,613,798 bp from pter |
End:
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70,694,585 bp from pter |
Size:
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80,788 bases |
Orientation:
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plus strand |
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Proteins
for IL34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4 (See
protein sequence)Recommended Name: Interleukin-34 precursor Size: 242 amino acids; 27482 Da
Subunit: Homodimer. Interacts with CSF1R
Subcellular location: Secreted
4 PDB 3D structures from  and Proteopedia  for IL34:4DKC (3D)
4DKD (3D)
4DKE (3D)
4DKF (3D)
Secondary accessions: B2RC28 B2Z4A8 B2ZC70 Q8N6L2Alternative splicing: 2 isoforms: Q6ZMJ4-1 Q6ZMJ4-2 Explore the universe of human proteins at neXtProt for IL34: NX_Q6ZMJ4
IL34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001166242.1 NP_001166243.1 NP_689669.2
ENSEMBL proteins: ENSP00000455240 ENSP00000288098 ENSP00000463886 ENSP00000397863
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
IL34 for ontologies About GeneDecksing
IL34 Antibody Products:
Assay Products for IL34: |
Protein
Domains /
Families
for IL34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL34 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ZMJ4ProtoNet protein and cluster: Q6ZMJ4 UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4Similarity: Belongs to the IL-34 family |
Function
for IL34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4Function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotesthe release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatoryprocesses. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in theregulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation ofMAPK1/ERK2 AND MAPK3/ERK1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL34 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL34 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for IL34 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL34 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL34 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
IL34 for ontologies About GeneDecksing
Animal Models:
6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Il34):
IL34 for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL34
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for IL34 (Q6ZMJ42, 3 ENSP000002880984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
IL34 for ontologies About GeneDecksing
|
Drugs & Compounds
for IL34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IL34
Search CenterWatch for drugs/clinical trials and news about IL34
|
Transcripts
for IL34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL34 gene (3 alternative transcripts): NM_001172771.1 NM_001172772.1 NM_152456.2 Unigene Cluster for IL34: Interleukin 34 Hs.744161 [show with all ESTs]Unigene Representative Sequence: NM_1524566 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000563721 ENST00000569641 ENST00000288098 ENST00000574181 ENST00000566361
ENST00000429149(uc002ezh.2 uc002ezi.2 uc021tkk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL34 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL34 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): IL34 (NM_001172771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL34 |
Additional cDNA sequence: AK172744.1 AK307727.1 AK308799.1 AK314913.1 BC029804.1 EU599219.1 EU636994.1 5 DOTS entries: DT.97811993 DT.301977 DT.100023883 DT.439557 DT.100673583 24/68 AceView cDNA sequences (see all 68): BX096539 BM919848 BM708599 CR615780 CA440839 CR592247 Z44473 BQ710080 BP338016 BQ711901 BQ706007 BQ710357 BM987832 BQ709387 BU147190 T33847 BM919043 BM008008 AA351654 BM805873 BI838467 BI751993 BX452501 BI821807
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for IL34 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b |
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| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IL34
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Expression
for IL34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCACCTG
About this image
See IL34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL34
SOURCE GeneReport for Unigene cluster: Hs.744161
UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantlyexpressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus,testis, ovary, small intestine, prostate and colon
SABiosciences Custom PCR Arrays for IL34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL34
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL34 |
Orthologs
for IL34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL34 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for IL34 (if available)
TreeFam Gene Tree for IL34 (if available) |
Paralogs
for IL34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL34 (70613798 - 70694585 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IL34
2 CNVs: 49742 49741 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL34 |
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Disorders
/ Diseases
for IL34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL34 for disorders About GeneDecksing
OMIM gene information: 612081
OMIM disorders: --
5  diseases for IL34: About MalaCardsrheumatoid arthritis synovitis arthritis ataxia
prostatitis
Export disorders for IL34 gene to outside databases
|
Publications
for IL34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL34 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with IL34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. (PubMed id 18467591)1, 2, 3 Lin H.... Williams L.T. (2008)
- Functional overlap but differential expression of CSF -1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. (PubMed id 20504948)1, 2 Wei S....Stanley E.R. (2010)
- Interleukin-34 produced by human fibroblast-like synov ial cells in rheumatoid arthritis supports osteoclastogenesis. (PubMed id 22264405)1 Hwang S.J....Chang E.J. (2012)
- Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. (PubMed id 23177320)1 Greter M....Becher B. (2012)
- Interleukin 34 expression is associated with synoviti s severity in rheumatoid arthritis patients. (PubMed id 22039170)1 Chemel M....Heymann D. (2012)
- IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation. (PubMed id 20489731)2 Chihara T.... Okada S. (2010)
- Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood. (PubMed id 20829061)2 Eda H.... Monahan J.B. (2010)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for IL34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing IL34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL34 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IL34 gene:
Search GeneIP for patents involving IL34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for IL34 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL34 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL34 | | | OriGene Protein Over-expression Lysate for IL34 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for IL34 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL34 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL34 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IL34 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL34 | | OriGene Custom Protein Services for IL34 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL34 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL34 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL34 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL34 |
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| | | | Search Tocris compounds for IL34 |
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 | | | IL34 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL34 |
|  |  |  | | | | ThermoFisher Antibodies for IL34 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL34 |
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