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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL34 Gene

protein-coding   GIFtS: 49
GCID: GC16P070680

Interleukin 34

(Previous name: chromosome 16 open reading frame 77)
(Previous symbol: C16orf77)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 341 2
C16orf771 2 3 5
IL-342 3
Chromosome 16 Open Reading Frame 771
interleukin-342

External Ids:    HGNC: 285291   Entrez Gene: 1464332   Ensembl: ENSG000001573687   OMIM: 6120815   UniProtKB: Q6ZMJ43   

Export aliases for IL34 gene to outside databases

Previous GC identifers: GC16P069239 GC16P056451


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL34 Gene:
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through
the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 (PubMed 18467591)).(supplied by
OMIM, May 2008)

GeneCards Summary for IL34 Gene: 
IL34 (interleukin 34) is a protein-coding gene. Diseases associated with IL34 include synovitis, and rheumatoid arthritis. GO annotations related to this gene include growth factor activity and macrophage colony-stimulating factor receptor binding.

UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4
Function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages.
Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in
inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and
differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors
stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1

Gene Wiki entry for IL34 (Interleukin 34) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL34 gene promoter:
         USF1   RFX1   Sp1   POU3F2   YY1   FOXL1   E47   AREB6   CP2   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL34 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

IL34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL34 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P070680:  view genomic region     (about GC identifiers)

Start:
70,613,798 bp from pter      End:
70,694,585 bp from pter
Size:
80,788 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4 (See protein sequence)
Recommended Name: Interleukin-34 precursor  
Size: 242 amino acids; 27482 Da
Subunit: Homodimer. Interacts with CSF1R
Subcellular location: Secreted
4 PDB 3D structures from and Proteopedia for IL34:
4DKC (3D)        4DKD (3D)        4DKE (3D)        4DKF (3D)    
Secondary accessions: B2RC28 B2Z4A8 B2ZC70 Q8N6L2
Alternative splicing: 2 isoforms:  Q6ZMJ4-1   Q6ZMJ4-2   

Explore the universe of human proteins at neXtProt for IL34: NX_Q6ZMJ4

Explore proteomics data for IL34 at MOPED 

IL34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL34 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001166242.1  NP_001166243.1  NP_689669.2  

ENSEMBL proteins: 
 ENSP00000455240   ENSP00000288098   ENSP00000463886   ENSP00000397863  

Human Recombinant Protein Products for IL34: 
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R&D Systems Recombinant & Natural Proteins for IL34 (IL-34)
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OriGene Purified Protein for IL34
OriGene Protein Over-expression Lysate for IL34
OriGene MassSpec for IL34 
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Novus Biologicals IL34 Proteins
Novus Biologicals IL34 Lysate
Sino Biological Recombinant Protein for IL34
Sino Biological Cell Lysate for IL34 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for IL34 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IDA18467591

IL34 for ontologies           About GeneDecksing



IL34 Antibody Products: 
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Assay Products for IL34: 
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R&D Systems ELISAs for IL34 (IL-34)         (see all)
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Cloud-Clone Corp. ELISAs for IL34 
Cloud-Clone Corp. CLIAs for IL34


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

1 InterPro protein domain:
 IPR020415 Interleukin-34

Graphical View of Domain Structure for InterPro Entry Q6ZMJ4

ProtoNet protein and cluster: Q6ZMJ4

UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4
Similarity: Belongs to the IL-34 family


IL34 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL34_HUMAN, Q6ZMJ4
Function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages.
Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in
inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and
differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors
stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005157macrophage colony-stimulating factor receptor binding IDA18467591
GO:0008083growth factor activity IEA--
     
IL34 for ontologies           About GeneDecksing


Phenotypes:
     6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il34):
 cellular  hematopoietic system  immune system  mortality/aging  nervous system 
 no phenotypic analysis 

IL34 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL34 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL34

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL34 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL34 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL34
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL34:
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SwitchGear 3'UTR luciferase reporter plasmidIL34 3' UTR sequence
Inhib. RNA
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL34

Gene Editing
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Clone
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OriGene ORF clones in mouse, rat for IL34
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): IL34 (NM_001172771)
Sino Biological Human cDNA Clone for IL34
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL34
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL34
Sirion Biotech Customized lentivirus for stable overexpression of IL34 
                     Customized lentivirus expression plasmids for stable overexpression of IL34 

Cell Line
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GenScript Custom overexpressing Cell Line Services for IL34
Search LifeMap BioReagents cell lines for IL34
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL34


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL34

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for IL34 (Q6ZMJ42, 3 ENSP000002880984) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ATXN1P542532, 3, ENSP000002447694MINT-2878820 I2D: score=2 STRING: ENSP00000244769
CSF1RENSP000002863014STRING: ENSP00000286301
IGHG1ENSP000003749904STRING: ENSP00000374990
IGKCENSP000003747774STRING: ENSP00000374777
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001934positive regulation of protein phosphorylation IDA18467591
GO:0006954inflammatory response IEA--
GO:0008284positive regulation of cell proliferation IDA18467591
GO:0045087innate immune response IEA--

IL34 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL34

Search CenterWatch for drugs/clinical trials and news about IL34

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL34 gene (3 alternative transcripts): 
NM_001172771.1  NM_001172772.1  NM_152456.2  

Unigene Cluster for IL34:

Interleukin 34
Hs.461214  [show with all ESTs]
Unigene Representative Sequence: NM_152456
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000563721 ENST00000569641 ENST00000288098 ENST00000574181 ENST00000566361
ENST00000429149(uc002ezh.2 uc002ezi.2 uc021tkk.1)
miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL34
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL34:
hsa-miR-31 hsa-miR-576-3p hsa-miR-633
SwitchGear 3'UTR luciferase reporter plasmidIL34 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL34
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL34
Clone
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL34
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL34
Sirion Biotech Customized lentivirus for stable overexpression of IL34 
                     Customized lentivirus expression plasmids for stable overexpression of IL34 
Primer
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OriGene qPCR primer pairs and template standards for IL34
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL34
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL34
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL34

Additional mRNA sequence: 

AK172744.1 AK307727.1 AK308799.1 AK314913.1 BC029804.1 EU599219.1 EU636994.1 

5 DOTS entries:

DT.97811993  DT.301977  DT.100023883  DT.100673583  DT.439557 

24/68 AceView cDNA sequences (see all 68):

BM708599 BQ709387 BQ711901 BQ706007 BQ710080 BM987832 CA440839 CR592247 
CR615780 BM919848 BP338016 BX096539 Z44473 BU147190 BQ710357 BM919043 
BG745622 BI916645 BI771169 BM008008 BM021990 AI903142 BI819311 BI918040 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IL34    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1:                    -                             -                     
SP2:                    -                             -                     
SP3:                                                                        
SP4:                    -     -                                             


ECgene alternative splicing isoforms for IL34

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTCACCTG
IL34 Expression
About this image


See IL34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL34

SOURCE GeneReport for Unigene cluster: Hs.461214

UniProtKB/Swiss-Prot: IL34_HUMAN, Q6ZMJ4
Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level).
Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver,
kidney, thymus, testis, ovary, small intestine, prostate and colon

    SABiosciences Custom PCR Arrays for IL34
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL34

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL34 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il341 , 5 interleukin 341, 5 78.02(n)1
70.74(a)1
  8 (57.68 cM)5
765271  NM_001135100.11  NP_001128572.11 
 1107418295 
chicken
(Gallus gallus)
Aves LOC1008584241 interleukin-34-like 58.94(n)
45.7(a)
  100858424  XM_003641892.1  XP_003641940.1 
zebrafish
(Danio rerio)
Actinopterygii IL34 (2 of 2)6
IL34 (1 of 2)6
interleukin 34
29(a)
29(a)
many → 1
many → 1
18(18309492-18325712)
18(18186339-18202526)


ENSEMBL Gene Tree for IL34 (if available)
TreeFam Gene Tree for IL34 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/2141 SNPs in IL34 are shown (see all 2141)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1860790291,2
--70612116(+) TGACAC/GAGATA 2 -- us2k10--------
rs1495460681,2
C--70612211(+) CCTCAA/GCTCCC 2 -- us2k10--------
rs1472424221,2
--70612221(+) CGTAAA/GTGCTG 2 -- us2k10--------
rs1153759631,2
C,F--70612239(+) GGCCAC/TGTGTT 2 -- us2k11Minor allele frequency- T:0.02WA 118
rs1910798941,2
--70612253(+) CCAGGA/TCAGGT 2 -- us2k10--------
rs1467162601,2
C--70612330(+) AAGAT-/TCTCTCT 2 -- us2k10--------
rs2005088541,2
--70612356(+) TCTCT-/CTTTTT 2 -- us2k10--------
rs763232791,2
C,F--70612357(+) TCTCTT/CTTTTT 2 -- us2k12Minor allele frequency- C:0.14WA EA 238
rs1169246841,2
F--70612448(+) AGCCTC/TGACCT 2 -- us2k11Minor allele frequency- T:0.03NA 120
rs1828583881,2
--70612483(+) CTCAGC/TCTCCC 2 -- us2k10--------

HapMap Linkage Disequilibrium report for IL34 (70613798 - 70694585 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for IL34:    About this table     
Variant IDTypeSubtypePubMed ID
esv2660602CNV Deletion23128226
nsv517391CNV Loss19592680
dgv2904n71CNV Loss21882294
nsv906881CNV Loss21882294
nsv906883CNV Loss21882294
dgv2906n71CNV Loss21882294
dgv2905n71CNV Loss21882294
esv26820CNV Loss19812545
nsv471094CNV Loss18288195
nsv7285OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 612081    OMIM disorders: --

4 diseases for IL34:    About MalaCards
synovitis    rheumatoid arthritis    arthritis    prostatitis


IL34 for disorders           About GeneDecksing


Export disorders for IL34 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL34 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with IL34)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. (PubMed id 18467591)1, 2, 3 Lin H.... Williams L.T. (2008)
  2. Functional overlap but differential expression of CSF -1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. (PubMed id 20504948)1, 2 Wei S....Stanley E.R. (2010)
  3. Cloning and expression of feline colony stimulating fa ctor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). (PubMed id 23260168)1 Gow D.J....Hume D.A. (2013)
  4. Interleukin-34 produced by human fibroblast-like synov ial cells in rheumatoid arthritis supports osteoclastogenesis. (PubMed id 22264405)1 Hwang S.J....Chang E.J. (2012)
  5. Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. (PubMed id 23177320)1 Greter M....Becher B. (2012)
  6. Interleukin 34 expression is associated with synoviti s severity in rheumatoid arthritis patients. (PubMed id 22039170)1 Chemel M....Heymann D. (2012)
  7. Increased serum interleukin-34 in patients with corona ry artery disease. (PubMed id 23206468)1 Li Z....Chen Z. (2012)
  8. IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation. (PubMed id 20489731)2 Chihara T.... Okada S. (2010)
  9. Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood. (PubMed id 20829061)2 Eda H.... Monahan J.B. (2010)
  10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 146433 HGNC: 28529 AceView: MGC34647 Ensembl:ENSG00000157368 euGenes: HUgn146433
ECgene: IL34 H-InvDB: IL34

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL34 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL34 gene:
Search GeneIP for patents involving IL34

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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