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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL33 Gene

protein-coding GIFtS: 55
GCID: GC09P006206

interleukin 33

(Previous name: chromosome 9 open reading frame 26 (NF-HEV) )
(Previous symbol: C9orf26)

Explore 22 diseases affiliated with
IL33 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 33¹ ²		NFEHEV² ⁵
C9orf26¹ ² ³ ⁵		DKFZp586H0523¹
IL1F11¹ ² ³		Chromosome 9 Open Reading Frame 26 (NF-HEV)¹
NF-HEV¹ ² ³		RP11-575C20.2²
DVS27¹ ²		DVS27-Related Protein²
Interleukin-1 Family Member 11² ³		Interleukin-33¹
Nuclear Factor From High Endothelial Venules² ³		Nuclear Factor For High Endothelial Venules²
IL-1F11² ³		NFHEV³
IL-33² ³

External Ids:	HGNC: 16028¹	Entrez Gene: 90865²	Ensembl: ENSG00000137033⁷	OMIM: 608678⁵	UniProtKB: O95760³

Export aliases for IL33 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL33:

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2

(Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family

receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 (PubMed

20926795)).(supplied by OMIM, Jan 2011)

UniProtKB/Swiss-Prot: IL33_HUMAN, O95760

Function: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and

TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type

2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies

immune responses during tissue injury

Function: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a

chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear

NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory

activation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL33 gene promoter:
HFH-3 FOXD3 Cdc5 HNF-3beta FOXI1 IRF-2 HFH-1 FOXJ2 (long isoform) FOXJ2 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL33 promoter sequence

Search SABiosciences Chromatin IP Primers for IL33

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL33

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24.1

IL33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL33 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P006206: view genomic region (about GC identifiers)

Start:	6,215,805 bp from pter	End:	6,257,983 bp from pter
Size:	42,179 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL33_HUMAN, O95760 (See protein sequence)

Recommended Name: Interleukin-33 precursor

Size: 270 amino acids; 30759 Da

Subunit: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP

Subcellular location: Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with

heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on

an intact microtubule network, and is ATP-dependent

1 PDB 3D structure from and Proteopedia for IL33:

2KLL (3D)

Secondary accessions: B4DJ35 B4E1Q9 D3DRI5 E7EAX4 Q2YEJ5

Alternative splicing: 4 isoforms: O95760-1 O95760-2 O95760-3 O95760-4 (Constitutively active)

Explore the universe of human proteins at neXtProt for IL33: NX_O95760

Post-translational modifications:

Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. Caspase-mediated proteolysis, once

thought to activate IL33, rather acts as a switch to dampen its activity. Cathepsin G and elastase can cleave IL33 and

generate highly active forms in activated neutrophils (IL-33(95-270), IL-33(99-270) and IL-33(109-270)). Proteolysis

is not strictly required for biological activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95760

IL33 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001186569.1 NP_001186570.1 NP_254274.1

ENSEMBL proteins:

ENSP00000370842 ENSP00000394039 ENSP00000414238

Human Recombinant Protein Products for IL33:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL33 (IL-33)
	Enzo Life Sciences proteins for IL33
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IL33 OriGene Custom Protein Services for IL33
	GenScript Purified and Recombinant Proteins for IL33
	Novus Biologicals IL33 Proteins Novus Biologicals IL33 Lysates
	Sino Biological Recombinant Protein for IL33
	ProSpec Recombinant Protein for IL33
	Uscn Proteins for IL33

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005694	chromosome	IEA	--
GO:0030133	transport vesicle	IEA	--

IL33 for ontologies About GeneDecksing

IL33 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IL33 (IL-33)
	OriGene Antibodies (see all 2): IL33 OriGene Custom Antibody Services for IL33
	GenScript Custom Superior Antibodies Services for IL33
	Novus Biologicals IL33 Antibodies
	Abcam antibodies for IL33
	Uscn Antibodies for IL33
	ThermoFisher Antibodies for IL33

Assay Products for IL33:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL33 (IL-33) (see all)
	GenScript Custom Assay Services for IL33
	Enzo Life Sciences assays for IL33
	Uscn ELISAs and CLIAs for IL33

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL33 for domains About GeneDecksing

1 InterPro domain/family:

IPR026145 IL33

Graphical View of Domain Structure for InterPro Entry O95760

ProtoNet protein and cluster: O95760

UniProtKB/Swiss-Prot: IL33_HUMAN, O95760

Domain: The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association

Similarity: Belongs to the IL-1 family. Highly divergent

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IL33_HUMAN, O95760

Function: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and

TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type

2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies

immune responses during tissue injury

Function: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a

chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear

NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory

activation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	19841166
GO:0005515	protein binding	IPI	16286016

IL33 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Il33):

digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
no phenotypic analysis	respiratory system

IL33 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Il33^tm1Aki for IL33

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL33

miRNA Products:		OriGene 3'-UTR Clone: IL33 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL33
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate IL33 (see all 10):
		hsa-miR-125a-3p hsa-miR-563 hsa-miR-3922-3p hsa-miR-380* hsa-miR-890 hsa-miR-1244 hsa-miR-3176 hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL33 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL33 (see all 7) OriGene shRNA RFP: IL33 OriGene siRNA: IL33
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL33
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL33

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IL33
			Sirion Biotech Customized adenovirus for overexpression of IL33 Sirion Biotech Customized adenovirus for potent knockdown of IL33

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL33 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL33 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL33 (NM_033439)
		Sino Biological Human cDNA Clone for IL33
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL33
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL33

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL33
		Search LifeMap BioReagents cell lines for IL33
		Sirion Biotech Customized stable knockdown cell line services for IL33 Sirion Biotech Customized inducible knockdown cell line services for IL33 Sirion Biotech Customized stable overexpressing cell line services for IL33 Sirion Biotech Customized inducible overexpressing cell line services for IL33

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL33

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytosolic DNA-sensing pathway

Cytosolic DNA-sensing pathway

1.00

Measles

Influenza A

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Kegg Pathways (Kegg details for IL33):

	Cytosolic DNA-sensing pathway
	Influenza A

IL33 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL33

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/16 Interacting proteins for IL33 (O95760^{1, 2, 3} ENSP00000370842⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H2AM	P0C0S8²^,³, ENSP00000352627⁴	MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 STRING: ENSP00000352627
HIST1H2AG	P0C0S8²^,³	MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1
HIST1H2AI	P0C0S8²^,³	MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1
HIST1H2AK	P0C0S8²^,³	MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1
HIST1H2AL	P0C0S8²^,³	MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002686	negative regulation of leukocyte migration	IEA	--
GO:0002826	negative regulation of T-helper 1 type immune response	IEA	--
GO:0002830	positive regulation of type 2 immune response	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0010628	positive regulation of gene expression	--	--

IL33 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL33
Search CenterWatch for drugs/clinical trials and news about IL33

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL33 gene (3 alternative transcripts):

NM_001199640.1 NM_001199641.1 NM_033439.3

Unigene Cluster for IL33:

Interleukin 33

Hs.731660 [show with all ESTs]

Unigene Representative Sequence: NM_033439

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381434(uc003zjt.3 uc011lmg.2 uc011lmh.2 uc022bdf.1)

ENST00000463336 ENST00000417746 ENST00000456383

miRNA Products:		OriGene 3'-UTR Clone: IL33 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL33
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate IL33 (see all 10):
		hsa-miR-125a-3p hsa-miR-563 hsa-miR-3922-3p hsa-miR-380* hsa-miR-890 hsa-miR-1244 hsa-miR-3176 hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL33 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL33 (see all 7) OriGene shRNA RFP: IL33 OriGene siRNA: IL33
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL33
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL33

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL33 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL33 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL33 (NM_033439)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL33
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL33

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL33 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL33
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL33
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL33

Additional cDNA sequence:

AB024518.1 AK295908.1 AK303943.1 AK313414.1 AL080211.1 AY905581.1 BC047085.1 CR407619.1

HQ641439.1

10 DOTS entries:

DT.113612 DT.92421695 DT.100781029 DT.95264625 DT.121206679 DT.95157170 DT.40229503 DT.91653907

DT.92030416 DT.92421694

24/135 AceView cDNA sequences (see all 135):

CA395511 AB024518 BQ894344 AL545473 AA449389 AA428482 AA315195 D79309

CD677493 NM_033439 CR407619 CB269662 BM956142 BG217190 BM955429 AI636918

BM955440 BX327752 AL080211 BG956756 BM955455 BX327751 BM955444 BQ878541

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCATCTGTG

About this image

IL33 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Ovary

Thoracic Perivascular Adipose

Adipose

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See IL33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL33

SOURCE GeneReport for Unigene cluster: Hs.731660

UniProtKB/Swiss-Prot: IL33_HUMAN, O95760

Tissue specificity: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric

lymph nodes. Almost undetectable in placenta

SABiosciences Expression via Pathway-Focused PCR Arrays including IL33:

Notch Signaling Targets in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Inflammasomes in human mouse rat

Common Cytokines in human mouse rat

Allergy & Asthma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL33 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL33
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL33
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL33

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL33

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL33 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il33^{1 , 5}	interleukin 33^{1, 5}	69.99(n)¹ 54.02(a)¹		19 (24.56 cM)⁵ 77125¹ NM_001164724.1¹ NP_001158196.1¹ 29925114⁵

ENSEMBL Gene Tree for IL33 (if available)
TreeFam Gene Tree for IL33 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189726269^1,2		--	6213790(+)	`GGCTCA/CCGCCT`	3	--	us2k¹		0	--	--	--	--
rs192639580^1,2		--	6213791(+)	`GCTCAC/GGCCTG`	3	--	us2k¹		0	--	--	--	--
rs145134649^1,2		--	6213792(+)	`CTCACA/GCCTGT`	3	--	us2k¹		0	--	--	--	--
rs184192098^1,2		--	6213801(+)	`GTAATC/GCCAGC`	3	--	us2k¹		0	--	--	--	--
rs10975487^1,2	C	--	6213818(+)	`GGAGGC/TCAAGG`	3	--	us2k¹		1		WA	2
rs142807069^1,2		--	6213820(+)	`AGGCCA/GAGGGG`	3	--	us2k¹		0	--	--	--	--
rs10815375^1,2	C,F,A	--	6213824(+)	`CAAGGC/G/TGGGCA`	3	--	us2k¹		3		NA WA	6
rs10975488^1,2	F	--	6213829(+)	`GGGGCG/AGATCA`	3	--	us2k¹		2		NA	4
rs189509774^1,2		--	6213837(+)	`TCACGA/CGGTCA`	3	--	us2k¹		0	--	--	--	--
rs181785227^1,2		--	6213842(+)	`AGGTCA/GGGAGA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL33 (6215805 - 6257983 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL33: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL33

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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IL33 for disorders           About GeneDecksing

OMIM gene information: 608678    OMIM disorders: --

20/22 diseases for IL33 (see all 22):    About MalaCards

pre-eclampsia systemic lupus erythematosus allergic rhinitis lupus erythematosus

inflammatory bowel disease allergic asthma ulcerative colitis myocardial infarction

eclampsia rheumatoid arthritis sepsis tonsillitis

arthritis rhinitis asthma polyposis

alzheimer's disease influenza obesity fibrosis

3 diseases from the University of Copenhagen DISEASES database for IL33:

Asthma Eosinophilia Hypersensitivity reaction type I disease

3 Novoseek disease relationships for IL33 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	41.8	5	19778913 (1), 17623648 (1), 17899542 (1), 18762778 (1) (see all 5)
arthritis	19	1	19248109 (1), 20081870 (1)
sepsis	0	3	20473304 (2), 20526314 (1)

Human Genome Epidemiology (HuGE) Navigator: IL33 (8 documents)

Export disorders for IL33 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL33 gene, integrated from 9 sources (see all 133):
(articles sorted by number of sources associating them with IL33)

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Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. (PubMed id 12819012)^{1, 2, 3, 9} Baekkevold E.S....Girard J.-P. (2003)
Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage. (PubMed id 10566975)^{1, 2, 3} Onda H.... Takeda J. (1999)
The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? (PubMed id 18836528)^{1, 2, 9} Moussion C....Girard J.P. (2008)
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. (PubMed id 17185418)^{1, 2, 9} Carriere V....Girard J.P. (2007)
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. (PubMed id 16286016)^{1, 2, 9} Schmitz J....Kastelein R.A. (2005)
Suppression of interleukin-33 bioactivity through pro teolysis by apoptotic caspases. (PubMed id 19559631)^{1, 2, 9} LA1thi A.U....Martin S.J. (2009)
Interleukin 33 as a mechanically responsive cytokine s ecreted by living cells. (PubMed id 22215666)^{1, 2} Kakkar R....Lee R.T. (2012)
IL-33 is processed into mature bioactive forms by neut rophil elastase and cathepsin G. (PubMed id 22307629)^{1, 2} Lefrancais E....Cayrol C. (2012)
Identification of constitutively active interleukin 3 3 (IL-33) splice variant. (PubMed id 21454686)^{1, 2} Hong J....Kim S. (2011)
The dual function cytokine IL-33 interacts with the t ranscription factor NF-I_B to dampen NF-I_B-stimulated gene transcription. (PubMed id 21734074)^{1, 2} Ali S....Martin M.U. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 90865	HGNC: 16028	AceView: C9orf26	Ensembl:ENSG00000137033	euGenes: HUgn90865
ECgene: IL33	Kegg: 90865	H-InvDB: IL33

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IL33	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IL33 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL33 gene:
Search GeneIP for patents involving IL33

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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IL33 Gene

interleukin 33

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IL33 Gene

interleukin 33

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