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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL33 Gene

protein-coding   GIFtS: 57
GCID: GC09P006206

Interleukin 33

(Previous name: chromosome 9 open reading frame 26 (NF-HEV))
(Previous symbol: C9orf26)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 331 2     NF-HEV2 3
C9orf261 2 3 5     NFEHEV2 5
DVS27-Related Protein1 2     Chromosome 9 Open Reading Frame 26 (NF-HEV)1
Nuclear Factor For High Endothelial Venules1 2     Interleukin-1 Family1
Interleukin-1 Family Member 112 3     Member 111
Nuclear Factor From High Endothelial Venules2 3     DVS272
IL-1F112 3     RP11-575C20.22
IL-332 3     interleukin-332
IL1F112 3     NFHEV3

External Ids:    HGNC: 160281   Entrez Gene: 908652   Ensembl: ENSG000001370337   OMIM: 6086785   UniProtKB: O957603   

Export aliases for IL33 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL33 Gene:
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2
(Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1
family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 (PubMed
20926795)).(supplied by OMIM, Jan 2011)

GeneCards Summary for IL33 Gene: 
IL33 (interleukin 33) is a protein-coding gene. Diseases associated with IL33 include allergic asthma, and endotheliitis, and among its related super-pathways are Cytosolic sensors of pathogen-associated DNA and Measles. GO annotations related to this gene include protein binding and cytokine activity.

UniProtKB/Swiss-Prot: IL33_HUMAN, O95760
Function: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4,
and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type
2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies
immune responses during tissue injury
Function: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a
chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear
NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory
activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL33 gene promoter:
         HFH-3   FOXD3   Cdc5   HNF-3beta   FOXI1   IRF-2   HFH-1   FOXJ2 (long isoform)   FOXJ2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL33 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

IL33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL33 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P006206:  view genomic region     (about GC identifiers)

Start:
6,215,786 bp from pter      End:
6,257,983 bp from pter
Size:
42,198 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL33_HUMAN, O95760 (See protein sequence)
Recommended Name: Interleukin-33 precursor  
Size: 270 amino acids; 30759 Da
Subunit: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor
IL1RAP
Subcellular location: Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with
heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends
on an intact microtubule network, and is ATP-dependent
1 PDB 3D structure from and Proteopedia for IL33:
2KLL (3D)    
Secondary accessions: B4DJ35 B4E1Q9 D3DRI5 E7EAX4 Q2YEJ5
Alternative splicing: 4 isoforms:  O95760-1   O95760-2   O95760-3   O95760-4   (Constitutively active)

Explore the universe of human proteins at neXtProt for IL33: NX_O95760

Explore proteomics data for IL33 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. Caspase-mediated proteolysis,
    once thought to activate IL33, rather acts as a switch to dampen its activity. Cathepsin G and elastase can
    cleave IL33 and generate highly active forms in activated neutrophils (IL-33(95-270), IL-33(99-270) and
    IL-33(109-270)). Proteolysis is not strictly required for biological activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95760

  • IL33 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL33 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186569.1  NP_001186570.1  NP_254274.1  

    ENSEMBL proteins: 
     ENSP00000370842   ENSP00000394039   ENSP00000414238  

    Human Recombinant Protein Products for IL33: 
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    R&D Systems Recombinant & Natural Proteins for IL33 (IL-33)
    Enzo Life Sciences proteins for IL33
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    OriGene Protein Over-expression Lysate for IL33
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IL33
    GenScript Purified and Recombinant Proteins for IL33
    Novus Biologicals IL33 Proteins
    Novus Biologicals IL33 Lysates
    Sino Biological Recombinant Protein for IL33
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL33
    Cloud-Clone Corp. Proteins for IL33 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--
    GO:0030133transport vesicle IEA--

    IL33 for ontologies           About GeneDecksing



    IL33 Antibody Products: 
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    Novus Biologicals IL33 Antibodies
    Abcam antibodies for IL33
    Cloud-Clone Corp. Antibodies for IL33 
    ThermoFisher Antibodies for IL33
    LSBio Antibodies in human, mouse, rat for IL33 

    Assay Products for IL33: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IL33 (IL-33)         (see all)
    GenScript Custom Assay Services for IL33
    Enzo Life Sciences assays for IL33
    Cloud-Clone Corp. ELISAs for IL33 
    Cloud-Clone Corp. CLIAs for IL33


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    1 InterPro protein domain:
     IPR026145 IL33

    Graphical View of Domain Structure for InterPro Entry O95760

    ProtoNet protein and cluster: O95760

    UniProtKB/Swiss-Prot: IL33_HUMAN, O95760
    Domain: The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association
    Similarity: Belongs to the IL-1 family. Highly divergent


    IL33 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL33_HUMAN, O95760
    Function: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4,
    and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type
    2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies
    immune responses during tissue injury
    Function: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a
    chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear
    NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory
    activation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA19841166
    GO:0005515protein binding IPI16286016
         
    IL33 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il33):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  respiratory system 

    IL33 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL33: Il33tm1Aki Il33tm1Amgn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL33 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL33 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL33 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL33
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate IL33 (see all 10):
    hsa-miR-125a-3p hsa-miR-563 hsa-miR-3922-3p hsa-miR-380* hsa-miR-890 hsa-miR-1244 hsa-miR-3176 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL33 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL33
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL33

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IL33
    Sirion Biotech Customized adenovirus for overexpression of IL33

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL33 (see all 7)
    OriGene ORF clones in mouse, rat for IL33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL33 (NM_033439)
    Sino Biological Human cDNA Clone for IL33
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL33
    Sirion Biotech Customized lentivirus for stable overexpression of IL33 
                         Customized lentivirus expression plasmids for stable overexpression of IL33 

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    GenScript Custom overexpressing Cell Line Services for IL33
    Search LifeMap BioReagents cell lines for IL33
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL33


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL33 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytosolic DNA-sensing pathway
    Cytosolic DNA-sensing pathway0.36
    2Influenza A
    Influenza A0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for IL33):
        Cytosolic DNA-sensing pathway
    Influenza A


    IL33 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL33

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/16 Interacting proteins for IL33 (O957601, 2, 3 ENSP000003708424) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2AMP0C0S82, 3, ENSP000003526274MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 STRING: ENSP00000352627
    HIST1H2AGP0C0S82, 3MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    HIST1H2AIP0C0S82, 3MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    HIST1H2AKP0C0S82, 3MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    HIST1H2ALP0C0S82, 3MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002686negative regulation of leukocyte migration IEA--
    GO:0002826negative regulation of T-helper 1 type immune response IEA--
    GO:0002830positive regulation of type 2 immune response IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010628positive regulation of gene expression ----

    IL33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL33

    Search CenterWatch for drugs/clinical trials and news about IL33

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL33 gene (3 alternative transcripts): 
    NM_001199640.1  NM_001199641.1  NM_033439.3  

    Unigene Cluster for IL33:

    Interleukin 33
    Hs.731660  [show with all ESTs]
    Unigene Representative Sequence: NM_033439
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381434(uc003zjt.3 uc011lmg.2 uc011lmh.2 uc022bdf.1)
    ENST00000463336 ENST00000417746 ENST00000456383

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL33
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate IL33 (see all 10):
    hsa-miR-125a-3p hsa-miR-563 hsa-miR-3922-3p hsa-miR-380* hsa-miR-890 hsa-miR-1244 hsa-miR-3176 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL33 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL33
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL33
    Clone
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    OriGene clones in human, mouse for IL33 (see all 7)
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    GenScript: all cDNA clones in your preferred vector (see all 3): IL33 (NM_033439)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL33
    Sirion Biotech Customized lentivirus for stable overexpression of IL33 
                         Customized lentivirus expression plasmids for stable overexpression of IL33 
    Primer
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    OriGene qPCR primer pairs and template standards for IL33
    OriGene qSTAR qPCR primer pairs in human, mouse for IL33
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL33
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL33
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL33

    Additional mRNA sequence: 

    AB024518.1 AK295908.1 AK303943.1 AK313414.1 AL080211.1 AY905581.1 BC047085.1 CR407619.1 
    HQ641439.1 

    10 DOTS entries:

    DT.113612  DT.92421695  DT.100781029  DT.95264625  DT.121206679  DT.95157170  DT.40229503  DT.91653907 
    DT.92030416  DT.92421694 

    24/135 AceView cDNA sequences (see all 135):

    AA315195 AA428482 CR407619 AB024518 D79309 CB269662 AA449389 BQ894344 
    AL545473 CA395511 NM_033439 CD677493 BM955436 BM955430 BM955427 BX502911 
    BX503215 BM955429 BM956142 BX327752 AW954874 BM993286 BG956756 AA582759 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL33 expression in normal human tissues (normalized intensities)      IL33 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATCTGTG
    IL33 Expression
    About this image


    IL33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 8 entries
             PureStem endothelial progenitor 30-SM2-1
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
             Human Pulmonary Artery Endothelial Cells (HPAEC)   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Mature Cardiac Fibroblasts Myocardium
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem progenitor F15
     
     Fibroblast (Uncategorized)    fully expand to see all 4 entries
             Human Lymphatic Fibroblasts (HLF)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human umbilical Smooth Muscle (HUSM)   

    See IL33 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL33

    SOURCE GeneReport for Unigene cluster: Hs.731660

    UniProtKB/Swiss-Prot: IL33_HUMAN, O95760
    Tissue specificity: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and
    mesenteric lymph nodes. Almost undetectable in placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL33: 
              Notch Signaling Targets in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammasomes in human mouse rat
              Common Cytokines in human mouse rat
              Allergy & Asthma in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL33
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL33 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il331 , 5 interleukin 331, 5 69.99(n)1
    54.02(a)1
      19 (24.56 cM)5
    771251  NM_001164724.11  NP_001158196.11 
     299251145 


    ENSEMBL Gene Tree for IL33 (if available)
    TreeFam Gene Tree for IL33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/984 SNPs in IL33 are shown (see all 984)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897262691,2
    --6213790(+) GGCTCA/CCGCCT 3 -- us2k10--------
    rs1926395801,2
    --6213791(+) GCTCAC/GGCCTG 3 -- us2k10--------
    rs1451346491,2
    --6213792(+) CTCACA/GCCTGT 3 -- us2k10--------
    rs1841920981,2
    --6213801(+) GTAATC/GCCAGC 3 -- us2k10--------
    rs109754871,2
    C,F--6213818(+) GGAGGC/TCAAGG 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1428070691,2
    C--6213820(+) AGGCCA/GAGGGG 3 -- us2k10--------
    rs108153751,2
    C,F,A--6213824(+) CAAGGC/G/TGGGCA 3 -- us2k13NA WA 6
    rs109754881,2
    C,F--6213829(+) GGGGCG/AGATCA 3 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1895097741,2
    C--6213837(+) TCACGA/CGGTCA 3 -- us2k10--------
    rs1817852271,2
    --6213842(+) AGGTCA/GGGAGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL33 (6215786 - 6257983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IL33:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674589CNV Deletion23128226
    nsv892159CNV Loss21882294
    nsv521598CNV Loss19592680
    nsv892157CNV Gain21882294
    nsv831496CNV Gain17160897
    nsv892158CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608678    OMIM disorders: --

    20/30 diseases for IL33 (see all 30):    About MalaCards
    allergic asthma    endotheliitis    allergic rhinitis    eosinophilia
    tonsillitis    rhinitis    interstitial lung disease    schistosomiasis
    eclampsia    pre-eclampsia    ulcerative colitis    psoriatic arthritis
    asthma    inflammatory bowel disease    arthritis    influenza
    myocardial infarction    osteoarthritis    endometriosis    peritonitis


    IL33 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for IL33 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 41.8 5 19778913 (1), 17623648 (1), 17899542 (1), 18762778 (1) (see all 5)
    arthritis 19 1 19248109 (1), 20081870 (1)
    sepsis 0 3 20473304 (2), 20526314 (1)

    Genetic Association Database (GAD): IL33
    Human Genome Epidemiology (HuGE) Navigator: IL33 (8 documents)

    Export disorders for IL33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL33 gene, integrated from 9 sources (see all 158):
    (articles sorted by number of sources associating them with IL33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. (PubMed id 12819012)1, 2, 3, 9 Baekkevold E.S....Girard J.-P. (2003)
    2. Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage. (PubMed id 10566975)1, 2, 3 Onda H.... Takeda J. (1999)
    3. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? (PubMed id 18836528)1, 2, 9 Moussion C....Girard J.P. (2008)
    4. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. (PubMed id 17185418)1, 2, 9 Carriere V....Girard J.P. (2007)
    5. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. (PubMed id 16286016)1, 2, 9 Schmitz J....Kastelein R.A. (2005)
    6. Suppression of interleukin-33 bioactivity through pro teolysis by apoptotic caspases. (PubMed id 19559631)1, 2, 9 LA1thi A.U....Martin S.J. (2009)
    7. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4, 9 Chapuis J....Lambert J.C. (2009)
    8. Interleukin 33 as a mechanically responsive cytokine s ecreted by living cells. (PubMed id 22215666)1, 2 Kakkar R....Lee R.T. (2012)
    9. IL-33 is processed into mature bioactive forms by neut rophil elastase and cathepsin G. (PubMed id 22307629)1, 2 Lefrancais E....Cayrol C. (2012)
    10. Identification of constitutively active interleukin 3 3 (IL-33) splice variant. (PubMed id 21454686)1, 2 Hong J....Kim S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90865 HGNC: 16028 AceView: C9orf26 Ensembl:ENSG00000137033 euGenes: HUgn90865
    ECgene: IL33 Kegg: 90865 H-InvDB: IL33

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL33 gene:
    Search GeneIP for patents involving IL33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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