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IL33 Gene

protein-coding   GIFtS: 54
GCID: GC09P006206

Interleukin 33

(Previous name: chromosome 9 open reading frame 26 (NF-HEV))
(Previous symbol: C9orf26)
  See IL33-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 331 2     NF-HEV2 3
C9orf261 2 3 5     NFEHEV2 5
DVS27-Related Protein1 2     Chromosome 9 Open Reading Frame 26 (NF-HEV)1
Nuclear Factor For High Endothelial Venules1 2     Interleukin-1 Family1
Interleukin-1 Family Member 112 3     Member 111
Nuclear Factor From High Endothelial Venules2 3     DVS272
IL-1F112 3     interleukin-332
IL-332 3     NFHEV3
IL1F112 3     

External Ids:    HGNC: 160281   Entrez Gene: 908652   Ensembl: ENSG000001370337   OMIM: 6086785   UniProtKB: O957603   

Export aliases for IL33 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL33 Gene:
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2
(Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1
family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 (PubMed
20926795)).(supplied by OMIM, Jan 2011)

GeneCards Summary for IL33 Gene:
IL33 (interleukin 33) is a protein-coding gene. Diseases associated with IL33 include allergic conjunctivitis. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL33_HUMAN, O95760
Function: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4,
and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type
2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies
immune responses during tissue injury
Function: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a
chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear
NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory
activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IL33 gene promoter:
         HFH-3   FOXD3   Cdc5   HNF-3beta   FOXI1   IRF-2   HFH-1   FOXJ2 (long isoform)   FOXJ2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL33 promoter sequence
   Search Chromatin IP Primers for IL33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

IL33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL33 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P006206:  view genomic region     (about GC identifiers)

Start:
6,215,786 bp from pter      End:
6,257,983 bp from pter
Size:
42,198 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL33_HUMAN, O95760 (See protein sequence)
Recommended Name: Interleukin-33 precursor  
Size: 270 amino acids; 30759 Da
Subunit: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor
IL1RAP
2 PDB 3D structures from and Proteopedia for IL33:
2KLL (3D)        4KC3 (3D)    
Secondary accessions: B4DJ35 B4E1Q9 D3DRI5 E7EAX4 Q2YEJ5
Alternative splicing: 4 isoforms:  O95760-1   O95760-2   O95760-3   O95760-4   (Constitutively active)

Explore the universe of human proteins at neXtProt for IL33: NX_O95760

Explore proteomics data for IL33 at MOPED

Post-translational modifications: 

  • Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. Caspase-mediated proteolysis,
    once thought to activate IL33, rather acts as a switch to dampen its activity. Cathepsin G and elastase can
    cleave IL33 and generate highly active forms in activated neutrophils (IL-33(95-270), IL-33(99-270) and
    IL-33(109-270)). Proteolysis is not strictly required for biological activity1
  • Modification sites at neXtProt

  • See IL33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186569.1  NP_001186570.1  NP_254274.1  

    ENSEMBL proteins: 
     ENSP00000370842   ENSP00000394039   ENSP00000414238  

    IL33 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL33 (IL-33)
    Enzo Life Sciences proteins for IL33
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    OriGene Protein Over-expression Lysate for IL33
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL33
    GenScript Purified and Recombinant Proteins for IL33
    Novus Biologicals IL33 Proteins
    Novus Biologicals IL33 Lysates
    Sino Biological Recombinant Protein for IL33
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL33
    Cloud-Clone Corp. Proteins for IL33

     
    eBioscience Proteins for IL33: (see all 2
                        Human IL-33 Recombinant Protein 5 ug

    IL33 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL33
    R&D Systems Antibodies for IL33 (IL-33)
    OriGene Antibodies for IL33
    OriGene Custom Antibody Services for IL33
    Novus Biologicals IL33 Antibodies
    Abcam antibodies for IL33
    Cloud-Clone Corp. Antibodies for IL33
    ThermoFisher Antibodies for IL33
    LSBio Antibodies in human, mouse, rat for IL33

    IL33 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL33
    R&D Systems ELISAs for IL33 (IL-33)         (see all)
    GenScript Custom Assay Services for IL33
    Enzo Life Sciences assays for IL33
    Cloud-Clone Corp. ELISAs for IL33
    Cloud-Clone Corp. CLIAs for IL33
    eBioscience ELISAs for IL33:  
                        Human IL-33 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    1 InterPro protein domain:
     IPR026145 IL-33

    Graphical View of Domain Structure for InterPro Entry O95760

    ProtoNet protein and cluster: O95760

    UniProtKB/Swiss-Prot: IL33_HUMAN, O95760
    Domain: The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association
    Similarity: Belongs to the IL-1 family. Highly divergent


    Find genes that share domains with IL33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL33_HUMAN, O95760
    Function: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4,
    and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type
    2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies
    immune responses during tissue injury
    Function: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a
    chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear
    NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory
    activation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA19841166
    GO:0005515protein binding IPI16286016
         
    Find genes that share ontologies with IL33           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Il33):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  respiratory system 

    Find genes that share phenotypes with IL33           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL33: Il33tm1Aki Il33tm1Amgn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL33
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL33

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL33:
    hsa-mir-335-5p (MIRT017750)

    Block miRNA regulation of human, mouse, rat IL33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL33 (see all 10):
    hsa-miR-125a-3p hsa-miR-563 hsa-miR-3922-3p hsa-miR-380* hsa-miR-890 hsa-miR-1244 hsa-miR-3176 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL33 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL33
    Predesigned siRNA for gene silencing in human, mouse, rat IL33

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL33

    Clone
    Products:
         
    OriGene clones in human, mouse for IL33 (see all 6)
    OriGene ORF clones in mouse, rat for IL33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL33 (NM_033439)
    Sino Biological Human cDNA Clone for IL33
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL33

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL33
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL33 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL33_HUMAN, O95760: Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with
    heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends
    on an intact microtubule network, and is ATP-dependent
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--
    GO:0030133transport vesicle IEA--

    Find genes that share ontologies with IL33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL33 About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44
    2Influenza A
    Influenza A0.34
    3Cytosolic sensors of pathogen-associated DNA
    Cytosolic DNA-sensing pathway0.33


    Find genes that share SuperPaths with IL33           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL33
        IL-1 Family Signaling Pathways




    2 Kegg Pathways  (Kegg details for IL33):
        Cytosolic DNA-sensing pathway
    Influenza A

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL33: 
              Notch Signaling Targets in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammasomes in human mouse rat
              Common Cytokines in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL33

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for IL33 (O957601, 2, 3 ENSP000003708424) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2AMP0C0S81, 2, 3, ENSP000003526274EBI-724057,EBI-1390628 MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 STRING: ENSP00000352627
    HIST1H2AGP0C0S81, 2, 3EBI-724057,EBI-1390628 MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    HIST1H2AIP0C0S81, 2, 3EBI-724057,EBI-1390628 MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    HIST1H2AKP0C0S81, 2, 3EBI-724057,EBI-1390628 MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    HIST1H2ALP0C0S81, 2, 3EBI-724057,EBI-1390628 MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002686negative regulation of leukocyte migration IEA--
    GO:0002826negative regulation of T-helper 1 type immune response IEA--
    GO:0002830positive regulation of type 2 immune response IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0010628positive regulation of gene expression ----

    Find genes that share ontologies with IL33           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL33



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL33 gene (3 alternative transcripts): 
    NM_001199640.1  NM_001199641.1  NM_033439.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381434(uc003zjt.3 uc011lmg.2 uc011lmh.2 uc022bdf.1)
    ENST00000463336 ENST00000417746 ENST00000456383
    miRNA
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    Block miRNA regulation of human, mouse, rat IL33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL33 (see all 10):
    hsa-miR-125a-3p hsa-miR-563 hsa-miR-3922-3p hsa-miR-380* hsa-miR-890 hsa-miR-1244 hsa-miR-3176 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL33 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL33
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    GenScript: all cDNA clones in your preferred vector (see all 3): IL33 (NM_033439)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL33
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL33
    OriGene qSTAR qPCR primer pairs in human, mouse for IL33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL33
      QuantiTect SYBR Green Assays in human, mouse, rat IL33
      QuantiFast Probe-based Assays in human, mouse, rat IL33

    Selected AceView cDNA sequences (see all 135):

    AB024518 CR407619 CA395511 AA428482 CD677493 AL545473 AA449389 BQ894344 
    NM_033439 AA315195 CB269662 D79309 BM993286 BM955436 AI610794 BV167555 
    BM955437 AI636918 BM955441 CD676849 AL545605 BM955429 BM955455 BM956143 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATCTGTG
    IL33 Expression
    About this image


    IL33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    IL33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL33 Protein Expression

    UniProtKB/Swiss-Prot: IL33_HUMAN, O95760
    Tissue specificity: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and
    mesenteric lymph nodes. Almost undetectable in placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL33: 
              Notch Signaling Targets in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammasomes in human mouse rat
              Common Cytokines in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
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    QuantiTect SYBR Green Assays in human, mouse, rat IL33
    QuantiFast Probe-based Assays in human, mouse, rat IL33
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL33 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il331 , 5 interleukin 331, 5 69.99(n)1
    54.02(a)1
      19 (24.56 cM)5
    771251  NM_001164724.11  NP_001158196.11 
     299251145 


    ENSEMBL Gene Tree for IL33 (if available)
    TreeFam Gene Tree for IL33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL33 (see all 984)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897262691,2
    --6213790(+) GGCTCA/CCGCCT 3 -- us2k10--------
    rs1926395801,2
    --6213791(+) GCTCAC/GGCCTG 3 -- us2k10--------
    rs1451346491,2
    --6213792(+) CTCACA/GCCTGT 3 -- us2k10--------
    rs1841920981,2
    --6213801(+) GTAATC/GCCAGC 3 -- us2k10--------
    rs109754871,2
    C,F--6213818(+) GGAGGC/TCAAGG 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1428070691,2
    C--6213820(+) AGGCCA/GAGGGG 3 -- us2k10--------
    rs108153751,2
    C,F,A--6213824(+) CAAGGC/G/TGGGCA 3 -- us2k13NA WA 6
    rs109754881,2
    C,F--6213829(+) GGGGCG/AGATCA 3 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1895097741,2
    C--6213837(+) TCACGA/CGGTCA 3 -- us2k10--------
    rs1817852271,2
    --6213842(+) AGGTCA/GGGAGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL33 (6215786 - 6257983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IL33:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674589CNV Deletion23128226
    nsv892159CNV Loss21882294
    nsv521598CNV Loss19592680
    nsv892157CNV Gain21882294
    nsv831496CNV Gain17160897
    nsv892158CNV Gain21882294

    Human Gene Mutation Database (HGMD): IL33
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL33
    DNA2.0 Custom Variant and Variant Library Synthesis for IL33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608678    OMIM disorders: --

    1 disease for IL33:    
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    allergic conjunctivitis


    Find genes that share disorders with IL33           About GenesLikeMe

    3 Novoseek inferred disease relationships for IL33 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 41.8 5 19778913 (1), 17623648 (1), 17899542 (1), 18762778 (1) (see all 5)
    arthritis 19 1 19248109 (1), 20081870 (1)
    sepsis 0 3 20473304 (2), 20526314 (1)

    Genetic Association Database (GAD): IL33
    Human Genome Epidemiology (HuGE) Navigator: IL33 (8 documents)

    Export disorders for IL33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL33 gene, integrated from 10 sources (see all 183):
    (articles sorted by number of sources associating them with IL33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. (PubMed id 12819012)1, 2, 3, 9 Baekkevold E.S....Girard J.-P. (Am. J. Pathol. 2003)
    2. Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage. (PubMed id 10566975)1, 2, 3 Onda H.... Takeda J. (J. Cereb. Blood Flow Metab. 1999)
    3. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? (PubMed id 18836528)1, 2, 9 Moussion C.... Girard J.P. (PLoS ONE 2008)
    4. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. (PubMed id 17185418)1, 2, 9 Carriere V.... Girard J.P. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. (PubMed id 16286016)1, 2, 9 Schmitz J....Kastelein R.A. (Immunity 2005)
    6. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. (PubMed id 19559631)1, 2, 9 Luthi A.U.... Martin S.J. (Immunity 2009)
    7. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4, 9 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    8. Interleukin 33 as a mechanically responsive cytokine secreted by living cells. (PubMed id 22215666)1, 2 Kakkar R.... Lee R.T. (J. Biol. Chem. 2012)
    9. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. (PubMed id 22307629)1, 2 Lefrancais E.... Cayrol C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Identification of constitutively active interleukin 33 (IL-33) splice variant. (PubMed id 21454686)1, 2 Hong J.... Kim S. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90865 HGNC: 16028 AceView: C9orf26 Ensembl:ENSG00000137033 euGenes: HUgn90865
    ECgene: IL33 Kegg: 90865 H-InvDB: IL33

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL33 gene:
    Search GeneIP for patents involving IL33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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