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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL32 Gene

protein-coding   GIFtS: 53
GCID: GC16P003120

interleukin 32
 Explore 46 diseases affiliated with
IL32 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL32    

Aliases
for IL32 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 321 2     IL-32gamma2
NK41 2 3 5     TAIFa2
TAIF1 2 3     TAIFc2
TAIFb1 2     Interleukin-321
TAIFd1 2     Interleukin-32 Eta2
Natural Killer Cells Protein 42 3     Interleukin-32 Small2
Tumor Necrosis Factor Alpha-Inducing Factor2 3     Interleukin-32 Theta2
IL-32alpha2     Natural Killer Cell Transcript 42
IL-32beta2     IL-323
IL-32delta2     

External Ids:    HGNC: 168301   Entrez Gene: 92352   Ensembl: ENSG000000085177   OMIM: 6060015   UniProtKB: P240013   

Export aliases for IL32 gene to outside databases

Previous GC identifers: GC16P003056 GC16P003057 GC16P003116 GC16P003118 GC16P003087


Summaries
for IL32 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL32:
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential
N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of
this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This
protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL32_HUMAN, P24001
Function: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as
TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK




Genomic Views
for IL32 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL32 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL32 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

IL32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL32 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003120:  view genomic region     (about GC identifiers)

Start:
 3,115,298 bp from pter      End:
 3,131,908 bp from pter
Size:
 16,611 bases      Orientation:
 plus strand

Proteins
for IL32 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL32_HUMAN, P24001 (See protein sequence)
Recommended Name: Interleukin-32 precursor  
Size: 234 amino acids; 26676 Da
Subcellular location: Secreted
Secondary accessions: A6NNM0 A8MPX0 B4DJM1 D3DUB0 D3DUB2 Q5VFH7 Q5VFH8 Q8WV38 Q96GK9
Alternative splicing: 6 isoforms:  P24001-1   P24001-2   P24001-3   P24001-4   P24001-5   P24001-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL32: NX_P24001

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24001

    • IL32 Protein expression data from MOPED and PaxDb:    About this image 
    IL32 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001012649.1  NP_001012650.1  NP_001012651.1  NP_001012652.1  NP_001012653.1  NP_001012654.1  NP_001012736.1  NP_004212.4  

    ENSEMBL proteins: 
     ENSP00000324742   ENSP00000431775   ENSP00000433177   ENSP00000380096   ENSP00000436937  
     ENSP00000450364   ENSP00000405063   ENSP00000437020   ENSP00000447496   ENSP00000432218  
     ENSP00000448354   ENSP00000432850   ENSP00000433747   ENSP00000411958   ENSP00000432917  
     ENSP00000008180   ENSP00000380099   ENSP00000431740   ENSP00000446624   ENSP00000433866  
     ENSP00000436929   ENSP00000447812   ENSP00000447033   ENSP00000449483   ENSP00000448683  
     ENSP00000446978   ENSP00000449147   ENSP00000447979   ENSP00000371648  

    Human Recombinant Protein Products for IL32: 
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    R&D Systems Recombinant & Natural Proteins for IL32 (IL-32 gamma, IL-32, IL-32 alpha)
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    OriGene Purified Proteins (see all 2): IL32
    OriGene Protein Over-expression Lysate (see all 8): IL32
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    Novus Biologicals IL32 Proteins
    Novus Biologicals IL32 Lysates
    Sino Biological Recombinant Protein for IL32
    ProSpec Recombinant Protein for IL32
    Uscn Proteins for IL32

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    IL32 for ontologies           About GeneDecksing



    IL32 Antibody Products: 
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    Uscn ELISAs and CLIAs for IL32

    Protein Domains /
    Families
    for IL32 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P24001


    Function
    for IL32 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL32_HUMAN, P24001
    Function: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as
    TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK
    Induction: Expression increased after activation of T-cells by mitogens or activation of NK cells by IL2/interleukin-2

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    IL32 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL32 

    miRNA
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    hsa-mir-205 (MIRT005564)

    OriGene 3'-UTR Clone (see all 8): IL32
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL32
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL32
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    Sirion Biotech Custom design and validation of potent shRNA sequences against IL32 

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL32 (see all 8)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 8): IL32 (NM_001012631)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL32 

    Cell Line
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    LifeMap BioReagents: cell line associated with IL32: PureStem ES-209, Meso-prx/latp Progenitor
    Sirion Biotech Customized stable knockdown cell line services for IL32 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL32


    Pathways & Interactions
    for IL32 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL32

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for IL32 (P240013 ENSP000003247424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRTN3P241583, ENSP000002343474I2D: score=1 STRING: ENSP00000234347
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS1729377
    GO:0006955immune response TAS1729377
    GO:0007155cell adhesion TAS1729377

    IL32 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL32 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL32 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL32
    4 Novoseek chemical compound relationships for IL32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polysulfone 45.3 1 1692717 (1)
    tyrosine 45.2 8 17981681 (1), 11118060 (1), 10589789 (1), 10699931 (1) (see all 6)
    matrigel 42.5 2 10699931 (1), 11829525 (1)
    vegf 8.66 6 11118060 (3), 15341989 (1)

    Search CenterWatch for drugs/clinical trials and news about IL32 

    Transcripts
    for IL32 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL32 gene (8 alternative transcripts): 
    NM_001012631.1  NM_001012632.1  NM_001012633.1  NM_001012634.1  NM_001012635.1  NM_001012636.1  NM_001012718.1  NM_004221.4  

    Unigene Cluster for IL32:

    Interleukin 32
    Hs.943  [show with all ESTs]
    Unigene Representative Sequence: BF569086
    18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000325568(uc002ctk.3 uc010uwp.2 uc010btb.3 uc002ctl.3 uc002ctm.3 uc002ctn.3)
    ENST00000534507(uc002cto.3) ENST00000531965 ENST00000396887 ENST00000532086
    ENST00000529699 ENST00000526464 ENST00000440815 ENST00000529550 ENST00000551122
    ENST00000525643(uc002ctp.3 uc002ctr.3 uc002ctt.3) ENST00000548807
    ENST00000528163 ENST00000530890 ENST00000444393 ENST00000533097 ENST00000534748
    ENST00000008180(uc010uwr.2 uc021tbc.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 8): IL32
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL32
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL32
    SwitchGear 3'UTR luciferase reporter plasmid: IL32 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL32
    OriGene shRNA RFP: IL32
    OriGene siRNA: IL32
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL32
    Sirion Biotech Custom design and validation of potent shRNA sequences against IL32 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL32 (see all 8)
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    GenScript: all cDNA clones in your preferred vector (see all 8): IL32 (NM_001012631)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL32 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL32
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL32

    Additional cDNA sequence: 

    AK296143.1 AK307158.1 AK310053.1 AY495331.1 AY495332.1 AY495333.1 BC009401.2 BC018782.1 
    BC105602.1 EU339107.1 FJ985780.1 FJ985781.1 JN546102.1 M59807.1 

    24/31 DOTS entries (see all 31):

    DT.100799255  DT.100799250  DT.456397  DT.95260562  DT.95260555  DT.120679684  DT.120679693  DT.100799247 
    DT.95260563  DT.100799244  DT.40132848  DT.100799249  DT.100799245  DT.101959172  DT.95260558  DT.120679700 
    DT.92440913  DT.120679689  DT.95260553  DT.95260556  DT.100799252  DT.95260557  DT.95310733  DT.91834522 

    24/375 AceView cDNA sequences (see all 375):

    BM773083 BM917244 BE019002 BQ052007 AA353529 AV656562 BM561930 BQ574309 
    BM842082 BM764938 NM_004221 CB111161 BM989904 AI523169 BM759359 BQ888029 
    BM764666 AA459180 CF127670 BG750845 CB164793 AU099298 BM817566 CR614804 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for IL32 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
    SP1:                                -     -     -     -     -     -     -     -     -                 -           -     -     -           -                 -   
    SP2:                                -     -     -     -     -     -     -     -     -                 -           -     -     -           -                     
    SP3:                                -     -     -     -     -     -     -     -     -                 -           -     -     -           -                     
    SP4:                                                                          -     -                 -           -     -     -           -                     
    SP5:                                                                                -                 -           -     -     -           -                     

    ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:  -     -     -                                       
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for IL32

    Expression
    for IL32 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTCTTTCC
    IL32 Expression
    About this image

    IL32 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL32

    SOURCE GeneReport for Unigene cluster: Hs.943

    UniProtKB/Swiss-Prot: IL32_HUMAN, P24001
    Tissue specificity: Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in
    non-immune cells

        SABiosciences Expression via Pathway-Focused PCR Array including IL32: 
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    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL32

    Orthologs
    for IL32 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for IL32 (if available)
    TreeFam Gene Tree for IL32 (if available) 

    Paralogs
    for IL32 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for IL32 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 NCBI SNPs in IL32 are shown (see all 249)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs346574691,2
    		C,F--3085466(+) GAAGCC/TTAAAG 8 -- us2k13Minor allele frequency- T:0.33NA 6
    rs560375661,2
    		C--3085588(+) TGGAAT/AGGACT 8 -- us2k13Minor allele frequency- A:0.20NA WA 240
    rs129184981,2
    		C--3085764(+) TTATTG/TGGAAA 8 -- us2k1 tfbs30--------
    rs1114978831,2
    		C,F--3085920(+) CTCCCG/AGGTTC 8 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1931022941,2
    		C--3086510(+) GAGCCC/TGTAGG 8 -- us2k10--------
    rs1112581141,2
    		C--3086549(+) CCTTCG/AGCCCC 8 -- us2k12Minor allele frequency- A:0.06NA 122
    rs1131244711,2
    		C--3086695(+) TCCAAC/TGTGCA 8 -- us2k10--------
    rs454992971,2
    		C,F--3086834(+) TTGGAT/CCCCAC 8 -- us2k15Minor allele frequency- C:0.25WA NA CSA 244
    rs765809471,2
    		C--3086887(+) CAGCTG/CTCCCG 8 -- ut51 us2k14Minor allele frequency- C:0.17NA CSA WA 241
    rs750703801,2
    		C,F--3086918(+) CCCTCC/TCCACT 8 -- ut51 us2k11Minor allele frequency- T:0.07WA 118

    HapMap Linkage Disequilibrium report for IL32 (3115298 - 3131908 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for IL32
         1 CNV: 49689
         4 Indels: 40128 11826 45417 41794

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for IL32 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL32 for disorders           About GeneDecksing

    OMIM gene information: 606001    OMIM disorders: --

    20/46 diseases for IL32 (see all 46):    About MalaCards
    venezuelan equine encephalitis    wegener's granulomatosis    myelomonocytic leukemia    myasthenia gravis
    chronic obstructive pulmonary disease    chronic myelomonocytic leukemia    inflammatory bowel disease    atopic dermatitis
    rheumatoid arthritis    chronic myeloid leukemia    myasthenia    myeloid leukemia
    encephalitis    pulmonary disease    multiple myeloma    hepatocellular carcinoma
    gallbladder cancer    myelodysplastic syndrome    pancreatitis    pancreatic carcinoma

    1 disease from the University of Copenhagen DISEASES database for IL32:
    Rheumatoid arthritis

    10/19 Novoseek disease relationships for IL32 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 60.3 34 12374695 (4), 16219131 (4), 15473922 (3), 12224019 (3) (see all 11)
    metastasis 48.5 39 15341989 (4), 19438869 (3), 15880501 (3), 20015005 (2) (see all 19)
    tumors 44.4 96 19438869 (5), 14555533 (4), 16219131 (4), 18646008 (4) (see all 32)
    necrosis 43.2 23 1692717 (3), 17078892 (2), 16466631 (1), 18577612 (1) (see all 14)
    rheumatoid arthritis 41 15 17984580 (3), 17619821 (3), 17078892 (1), 18771438 (1) (see all 7)
    cancer 35.2 50 12824898 (4), 17981681 (3), 18646008 (3), 15950947 (3) (see all 20)
    pancreatic tumor 27.8 4 11606388 (2)
    pancreatic carcinoma 25.5 3 11606388 (2), 12198770 (1)
    colitis 11.9 4 17078892 (2), 17590175 (1)
    primary tumor 11.6 7 11118060 (2), 15026993 (1)

    Human Genome Epidemiology (HuGE) Navigator: IL32 (2 documents)

    Export disorders for IL32 gene to outside databases

    Publications
    for IL32 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL32 gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with IL32)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene expressed in activated natural killer cells and T cells. (PubMed id 1729377)1, 2, 3, 9 Dahl C.A.... Cairns J.S. (1992)
    2. Interleukin-32: a cytokine and inducer of TNFalpha. (PubMed id 15664165)1, 2, 9 Kim S.-H.... Dinarello C.A. (2005)
    3. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1, 2 Oh J.H....Kim N.S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A transcriptional map of the FMF region. (PubMed id 9653642)1, 3 Bernot A.... Weissenbach J. (1998)
    6. Interleukin-32 expression in the pancreas. (PubMed id 19386602)1, 9 Nishida A....Fujiyama Y. (2009)
    7. Effects of transferred NK4 gene on proliferation, mig ration, invasion and apoptosis of human prostate cancer DU145 cells. (PubMed id 20400971)1, 9 Yue D....Ren C.S. (2010)
    8. A proinflammatory cytokine interleukin-32beta promote s the production of an anti-inflammatory cytokine interleukin-10. (PubMed id 19740314)1, 9 Kang J.W....Yoon D.Y. (2009)
    9. Proteinase 3-processed form of the recombinant IL-32 separate domain. (PubMed id 19017495)1, 9 Kim S....Kim S. (2008)
    10. IL-32-dependent effects of IL-1beta on endothelial cell functions. (PubMed id 19228941)1, 9 Nold-Petry C.A....Dinarello C.A. (2009)

    External Searches for IL32 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL32 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9235 HGNC: 16830 AceView: NK4 Ensembl:ENSG00000008517 euGenes: HUgn9235
    ECgene: IL32 H-InvDB: IL32

    Other Databases showing IL32 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL32 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL32 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IL32 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL32 gene:
    Search GeneIP for patents involving IL32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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