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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL32 Gene

protein-coding   GIFtS: 56
GCID: GC16P003131

Interleukin 32

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 321 2     TAIFa2
NK42 3 5     TAIFb2
Natural Killer Cell Transcript 41 2     TAIFc2
Natural Killer Cells Protein 42 3     TAIFd2
Tumor Necrosis Factor Alpha-Inducing Factor2 3     interleukin-322
TAIF2 3     Interleukin-32 Eta2
IL-32alpha2     Interleukin-32 Small2
IL-32beta2     Interleukin-32 Theta2
IL-32delta2     IL-323
IL-32gamma2     

External Ids:    HGNC: 168301   Entrez Gene: 92352   Ensembl: ENSG000000085177   OMIM: 6060015   UniProtKB: P240013   

Export aliases for IL32 gene to outside databases

Previous GC identifers: GC16P003056 GC16P003057 GC16P003116 GC16P003118 GC16P003087 GC16P003120


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL32 Gene:
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential
N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression
of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2.
This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL32 Gene: 
IL32 (interleukin 32) is a protein-coding gene. Diseases associated with IL32 include venezuelan equine encephalitis, and chronic myelomonocytic leukemia. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL32_HUMAN, P24001
Function: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such
as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL32 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL32 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

IL32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL32 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003131:  view genomic region     (about GC identifiers)

Start:
3,115,298 bp from pter      End:
3,131,908 bp from pter
Size:
16,611 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL32_HUMAN, P24001 (See protein sequence)
Recommended Name: Interleukin-32 precursor  
Size: 234 amino acids; 26676 Da
Subcellular location: Secreted
Secondary accessions: A6NNM0 A8MPX0 B4DJM1 D3DUB0 D3DUB2 Q5VFH7 Q5VFH8 Q8WV38 Q96GK9
Alternative splicing: 6 isoforms:  P24001-1   P24001-2   P24001-3   P24001-4   P24001-5   P24001-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL32: NX_P24001

Explore proteomics data for IL32 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24001

  • IL32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL32 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001012649.1  NP_001012650.1  NP_001012651.1  NP_001012652.1  NP_001012653.1  NP_001012654.1  NP_001012736.1  NP_004212.4  

    ENSEMBL proteins: 
     ENSP00000324742   ENSP00000431775   ENSP00000433177   ENSP00000380096   ENSP00000436937  
     ENSP00000450364   ENSP00000405063   ENSP00000437020   ENSP00000447496   ENSP00000432218  
     ENSP00000448354   ENSP00000432850   ENSP00000433747   ENSP00000411958   ENSP00000432917  
     ENSP00000008180   ENSP00000380099   ENSP00000431740   ENSP00000446624   ENSP00000433866  
     ENSP00000436929   ENSP00000447812   ENSP00000447033   ENSP00000449483   ENSP00000448683  
     ENSP00000446978   ENSP00000449147   ENSP00000447979   ENSP00000371648  

    Human Recombinant Protein Products for IL32: 
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    Sino Biological Recombinant Protein for IL32
    Sino Biological Cell Lysate for IL32 
    ProSpec Recombinant Protein for IL32
    Cloud-Clone Corp. Proteins for IL32 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    IL32 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for IL32


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    ProtoNet protein and cluster: P24001


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL32_HUMAN, P24001
    Function: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such
    as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK
    Induction: Expression increased after activation of T-cells by mitogens or activation of NK cells by
    IL2/interleukin-2

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    IL32 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL32 
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    miRTarBase miRNAs that target IL32:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL32


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL32

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for IL32 (P240013 ENSP000003247424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRTN3P241583, ENSP000002343474I2D: score=1 STRING: ENSP00000234347
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS1729377
    GO:0006955immune response IEA--
    GO:0007155cell adhesion TAS1729377

    IL32 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL32 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL32

    4 Novoseek inferred chemical compound relationships for IL32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polysulfone 45.3 1 1692717 (1)
    tyrosine 45.2 8 17981681 (1), 11118060 (1), 10589789 (1), 10699931 (1) (see all 6)
    matrigel 42.5 2 10699931 (1), 11829525 (1)
    vegf 8.66 6 11118060 (3), 15341989 (1)

    Search CenterWatch for drugs/clinical trials and news about IL32

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL32 gene (8 alternative transcripts): 
    NM_001012631.1  NM_001012632.1  NM_001012633.1  NM_001012634.1  NM_001012635.1  NM_001012636.1  NM_001012718.1  NM_004221.4  

    Unigene Cluster for IL32:

    Interleukin 32
    Hs.943  [show with all ESTs]
    Unigene Representative Sequence: BF569086
    18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000325568(uc002ctk.3 uc010uwp.2 uc010btb.3 uc002ctl.3 uc002ctm.3 uc002ctn.3)
    ENST00000534507(uc002cto.3) ENST00000531965 ENST00000396887 ENST00000532086
    ENST00000529699 ENST00000526464 ENST00000440815 ENST00000529550 ENST00000551122
    ENST00000525643(uc002ctp.3 uc002ctr.3 uc002ctt.3) ENST00000548807
    ENST00000528163 ENST00000530890 ENST00000444393 ENST00000533097 ENST00000534748
    ENST00000008180(uc010uwr.2 uc021tbc.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL32
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL32
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL32

    Additional mRNA sequence: 

    AK296143.1 AK307158.1 AK310053.1 AY495331.1 AY495332.1 AY495333.1 BC009401.2 BC018782.1 
    BC105602.1 EU339107.1 FJ985780.1 FJ985781.1 JN546102.1 M59807.1 

    24/31 DOTS entries (see all 31):

    DT.100799255  DT.100799250  DT.456397  DT.95260562  DT.95260555  DT.120679684  DT.120679693  DT.100799247 
    DT.95260563  DT.100799244  DT.40132848  DT.100799249  DT.100799245  DT.101959172  DT.95260558  DT.120679700 
    DT.92440913  DT.120679689  DT.95260553  DT.95260556  DT.100799252  DT.95260557  DT.95310733  DT.91834522 

    24/375 AceView cDNA sequences (see all 375):

    AA459180 AI278694 BG748458 AI244991 BM989904 BM842082 BM769111 CR614804 
    CR612743 AA359342 BG750845 BE019002 BQ574309 BM764666 BQ052007 BQ083646 
    BM769883 BC018782 AU099298 CD368229 CB111161 AW005138 CB110148 BM840521 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for IL32 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
    SP1:                                -     -     -     -     -     -     -     -     -                 -           -     -     -           -                 -   
    SP2:                                -     -     -     -     -     -     -     -     -                 -           -     -     -           -                     
    SP3:                                -     -     -     -     -     -     -     -     -                 -           -     -     -           -                     
    SP4:                                                                          -     -                 -           -     -     -           -                     
    SP5:                                                                                -                 -           -     -     -           -                     

    ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:  -     -     -                                       
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for IL32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL32 expression in normal human tissues (normalized intensities)      IL32 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCTTTCC
    IL32 Expression
    About this image


    IL32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 12 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Double Positive Thymocytes Thymus
             PureStem endothelial Progenitor 30-SM2-3
             Peripheral blood Pan-T Cells   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem Progenitor E44
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Artery Endothelial Cells (HUAEC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   

    See IL32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL32

    SOURCE GeneReport for Unigene cluster: Hs.943

    UniProtKB/Swiss-Prot: IL32_HUMAN, P24001
    Tissue specificity: Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in
    non-immune cells

        SABiosciences Expression via Pathway-Focused PCR Array including IL32: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for IL32 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia IL321 interleukin 32 98.4(n)
    95.21(a)
      100614360  XM_003339278.2  XP_003339326.1 


    ENSEMBL Gene Tree for IL32 (if available)
    TreeFam Gene Tree for IL32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/340 SNPs in IL32 are shown (see all 340)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0055064
    ----see VAR_0055062 D N mis40--------
    rs1457537151,2
    --3049374(+) CATGCC/GTGTAA 4 -- us2k10--------
    rs1410548281,2
    --3049462(+) ACCCCA/GTCTCT 4 -- us2k10--------
    rs1919347241,2
    --3049520(+) CCCAGC/TTACTC 4 -- us2k10--------
    rs1433735281,2
    C--3049587(+) GAGATC/TGTGCC 4 -- us2k10--------
    rs1467122901,2
    --3049619(+) CAGAGC/TGAGAC 4 -- us2k10--------
    rs1830304741,2
    --3049694(+) GTGATA/GTCTCA 7 -- us2k10--------
    rs1876009071,2
    --3049758(+) TGATAA/GCTGCA 7 -- us2k10--------
    rs1404171801,2
    --3049783(+) GAATTA/GTACAG 7 -- us2k10--------
    rs1435866721,2
    --3049791(+) CAGCTC/TAATGA 7 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL32 (3115298 - 3131908 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for IL32 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750395CNV Deletion23290073
    esv2750398CNV Deletion23290073
    esv2750397CNV Deletion23290073
    esv2750390CNV Deletion23290073
    esv3251CNV Deletion18987735
    esv2750394CNV Deletion23290073
    esv2103609CNV Deletion18987734
    nsv509589CNV Insertion20534489
    nsv905199CNV Loss21882294
    dgv2580n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606001    OMIM disorders: --

    20/38 diseases for IL32 (see all 38):    About MalaCards
    venezuelan equine encephalitis    chronic myelomonocytic leukemia    gallbladder cancer    pancreatic cancer
    wegener's granulomatosis    myasthenia gravis    encephalitis    peritonitis
    chronic myeloid leukemia    chronic obstructive pulmonary disease    gastric cancer    atopic dermatitis
    rheumatoid arthritis    myelodysplastic syndromes    pancreatitis    hepatocellular carcinoma
    arthritis    colon cancer    multiple myeloma    osteoarthritis

    1 disease from the University of Copenhagen DISEASES database for IL32:
    Rheumatoid arthritis

    IL32 for disorders           About GeneDecksing

    10/19 Novoseek inferred disease relationships for IL32 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 60.3 34 12374695 (4), 16219131 (4), 15473922 (3), 12224019 (3) (see all 11)
    metastasis 48.5 39 15341989 (4), 19438869 (3), 15880501 (3), 20015005 (2) (see all 19)
    tumors 44.4 96 19438869 (5), 14555533 (4), 16219131 (4), 18646008 (4) (see all 32)
    necrosis 43.2 23 1692717 (3), 17078892 (2), 16466631 (1), 18577612 (1) (see all 14)
    rheumatoid arthritis 41 15 17984580 (3), 17619821 (3), 17078892 (1), 18771438 (1) (see all 7)
    cancer 35.2 50 12824898 (4), 17981681 (3), 18646008 (3), 15950947 (3) (see all 20)
    pancreatic tumor 27.8 4 11606388 (2)
    pancreatic carcinoma 25.5 3 11606388 (2), 12198770 (1)
    colitis 11.9 4 17078892 (2), 17590175 (1)
    primary tumor 11.6 7 11118060 (2), 15026993 (1)

    Genetic Association Database (GAD): IL32
    Human Genome Epidemiology (HuGE) Navigator: IL32 (2 documents)

    Export disorders for IL32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL32 gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with IL32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene expressed in activated natural killer cells and T cells. (PubMed id 1729377)1, 2, 3, 9 Dahl C.A.... Cairns J.S. (1992)
    2. Interleukin-32: a cytokine and inducer of TNFalpha. (PubMed id 15664165)1, 2, 9 Kim S.-H.... Dinarello C.A. (2005)
    3. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (2011)
    4. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1, 2 Oh J.H....Kim N.S. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A transcriptional map of the FMF region. (PubMed id 9653642)1, 3 Bernot A.... Weissenbach J. (1998)
    7. Interleukin-32 expression in the pancreas. (PubMed id 19386602)1, 9 Nishida A....Fujiyama Y. (2009)
    8. Effects of transferred NK4 gene on proliferation, mig ration, invasion and apoptosis of human prostate cancer DU145 cells. (PubMed id 20400971)1, 9 Yue D....Ren C.S. (2010)
    9. A proinflammatory cytokine interleukin-32beta promote s the production of an anti-inflammatory cytokine interleukin-10. (PubMed id 19740314)1, 9 Kang J.W....Yoon D.Y. (2009)
    10. Proteinase 3-processed form of the recombinant IL-32 separate domain. (PubMed id 19017495)1, 9 Kim S....Kim S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9235 HGNC: 16830 AceView: NK4 Ensembl:ENSG00000008517 euGenes: HUgn9235
    ECgene: IL32 H-InvDB: IL32

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL32 gene:
    Search GeneIP for patents involving IL32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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