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Aliases for IL32 Gene

Aliases for IL32 Gene

  • Interleukin 32 2 3 5
  • Tumor Necrosis Factor Alpha-Inducing Factor 3 4
  • Natural Killer Cell Transcript 4 2 3
  • Natural Killer Cells Protein 4 3 4
  • TAIF 3 4
  • NK4 3 4
  • Interleukin-32 Small 3
  • Interleukin-32 Theta 3
  • Interleukin-32 Eta 3
  • Interleukin-32 3
  • IL-32alpha 3
  • IL-32delta 3
  • IL-32gamma 3
  • IL-32beta 3
  • TAIFa 3
  • TAIFb 3
  • TAIFc 3
  • TAIFd 3
  • IL-32 4

External Ids for IL32 Gene

Previous GeneCards Identifiers for IL32 Gene

  • GC16P003056
  • GC16P003057
  • GC16P003116
  • GC16P003118
  • GC16P003087
  • GC16P003120
  • GC16P003131
  • GC16P003153
  • GC16P003167
  • GC16P003181
  • GC16P003213
  • GC16P003263

Summaries for IL32 Gene

Entrez Gene Summary for IL32 Gene

  • This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL32 Gene

IL32 (Interleukin 32) is a Protein Coding gene. Diseases associated with IL32 include Venezuelan Equine Encephalitis and Pancreatic Cancer. Among its related pathways are Immune System and Cytokine Signaling in Immune system. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL32 Gene

  • Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL32 Gene

Genomics for IL32 Gene

Regulatory Elements for IL32 Gene

Enhancers for IL32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003063 1.4 FANTOM5 ENCODE 22 +0.8 761 5.8 HDGF PKNOX1 ATF1 MLX WRNIP1 ARID4B DMAP1 ZNF48 YY1 ZNF121 IL32 MMP25 LOC105371058 ZNF597 CREBBP BICDL2 ZSCAN10 LOC100128770 LOC107984895 ENSG00000260447
GH16F003069 1.7 FANTOM5 Ensembl ENCODE 15.3 +9.1 9083 9.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 LOC105371058 MMP25 IL32 ZNF205 BICDL2 LOC100128770 CLDN6 THOC6 HCFC1R1 TNFRSF12A
GH16F003058 1 ENCODE 21.7 -5.6 -5619 2.4 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 ZNF143 KLF13 ZNF597 IL32 CREBBP BICDL2 THOC6 ZNF263 LOC105371055 SNORD60 MMP25-AS1
GH16F003061 1.1 Ensembl 19 -3.0 -2997 1.4 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 DEK SP3 SP5 IL32 BICDL2 MMP25-AS1
GH16F003052 1.3 Ensembl ENCODE 15.5 -10.7 -10697 4.4 ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 ZNF207 KLF13 ZNF263 SP3 MMP25 BICDL2 IL32 CLDN6 TNFRSF12A ZNF205 CLDN9 PKMYT1 GC16P003092
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL32 on UCSC Golden Path with GeneCards custom track

Promoters for IL32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000664544 1003 2201 ATF1 MLX WRNIP1 ARID4B DMAP1 ZNF48 YY1 GLIS2 ZNF143 KLF7

Genomic Location for IL32 Gene

Chromosome:
16
Start:
3,065,297 bp from pter
End:
3,082,192 bp from pter
Size:
16,896 bases
Orientation:
Plus strand

Genomic View for IL32 Gene

Genes around IL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL32 Gene

Proteins for IL32 Gene

  • Protein details for IL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24001-IL32_HUMAN
    Recommended name:
    Interleukin-32
    Protein Accession:
    P24001
    Secondary Accessions:
    • A6NNM0
    • A8MPX0
    • B4DJM1
    • B8Q191
    • D3DUB0
    • D3DUB2
    • Q5VFH7
    • Q5VFH8
    • Q8WV38
    • Q96GK9

    Protein attributes for IL32 Gene

    Size:
    234 amino acids
    Molecular mass:
    26676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL32 Gene

neXtProt entry for IL32 Gene

Post-translational modifications for IL32 Gene

  • Ubiquitination at Lys 51, Lys 74, and Lys 153
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for IL32

No data available for DME Specific Peptides for IL32 Gene

Domains & Families for IL32 Gene

Gene Families for IL32 Gene

Protein Domains for IL32 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL32: view

No data available for UniProtKB/Swiss-Prot for IL32 Gene

Function for IL32 Gene

Molecular function for IL32 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.
UniProtKB/Swiss-Prot Induction:
Expression increased after activation of T-cells by mitogens or activation of NK cells by IL2/interleukin-2.

Gene Ontology (GO) - Molecular Function for IL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 23814099
genes like me logo Genes that share ontologies with IL32: view
genes like me logo Genes that share phenotypes with IL32: view

Animal Model Products

miRNA for IL32 Gene

miRTarBase miRNAs that target IL32

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL32 Gene

Localization for IL32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL32 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL32 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for IL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IL32: view

Pathways & Interactions for IL32 Gene

genes like me logo Genes that share pathways with IL32: view

Pathways by source for IL32 Gene

Gene Ontology (GO) - Biological Process for IL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 1729377
GO:0006955 immune response IEA --
GO:0007155 cell adhesion TAS 1729377
genes like me logo Genes that share ontologies with IL32: view

No data available for SIGNOR curated interactions for IL32 Gene

Drugs & Compounds for IL32 Gene

(1) Drugs for IL32 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for IL32 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL32: view

Transcripts for IL32 Gene

Unigene Clusters for IL32 Gene

Interleukin 32:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL32 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - -
SP17: - -
SP18: - -
SP19: - - -
SP20:
SP21:

ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for IL32 Gene

GeneLoc Exon Structure for
IL32
ECgene alternative splicing isoforms for
IL32

Expression for IL32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL32 Gene

mRNA differential expression in normal tissues according to GTEx for IL32 Gene

This gene is overexpressed in Liver (x9.1), Whole Blood (x5.9), Pancreas (x5.8), and Kidney - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for IL32 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IL32 Gene



Protein tissue co-expression partners for IL32 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL32 Gene:

IL32

SOURCE GeneReport for Unigene cluster for IL32 Gene:

Hs.943

mRNA Expression by UniProt/SwissProt for IL32 Gene:

P24001-IL32_HUMAN
Tissue specificity: Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.
genes like me logo Genes that share expression patterns with IL32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL32 Gene

Orthologs for IL32 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for IL32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL32 34 35
  • 98.4 (n)
Species where no ortholog for IL32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL32 Gene

ENSEMBL:
Gene Tree for IL32 (if available)
TreeFam:
Gene Tree for IL32 (if available)

Paralogs for IL32 Gene

No data available for Paralogs for IL32 Gene

Variants for IL32 Gene

Sequence variations from dbSNP and Humsavar for IL32 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111258114 -- 3,064,986(+) CCTTC(A/G)GCCCC upstream-variant-2KB
rs111283867 -- 3,068,852(+) GCCCA(C/T)GGGGC intron-variant
rs111432878 -- 3,069,471(+) TTCCT(A/G)CCGCA utr-variant-3-prime
rs111457614 -- 3,067,037(+) GCCCA(C/T)GCAGG intron-variant
rs111497883 -- 3,064,357(+) CTCCC(A/G)GGTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL32 Gene

Variant ID Type Subtype PubMed ID
dgv159n21 CNV loss 19592680
esv2103609 CNV deletion 18987734
esv2750390 CNV deletion 23290073
esv2750394 CNV deletion 23290073
esv2750395 CNV deletion 23290073
esv2750397 CNV deletion 23290073
esv2750398 CNV deletion 23290073
esv2761891 CNV loss 21179565
esv2763127 CNV loss 21179565
esv3251 CNV loss 18987735
esv3581939 CNV loss 25503493
esv3581940 CNV loss 25503493
esv3637646 CNV loss 21293372
esv3637647 CNV gain 21293372
esv3892758 CNV loss 25118596
nsv103250 CNV deletion 16902084
nsv509589 CNV insertion 20534489
nsv515926 CNV loss 19592680
nsv571248 CNV loss 21841781
nsv833125 CNV loss 17160897

Variation tolerance for IL32 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL32 Gene

Human Gene Mutation Database (HGMD)
IL32
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL32 Gene

Disorders for IL32 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IL32 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
venezuelan equine encephalitis
  • venezuelan equine fever
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search IL32 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL32

Genetic Association Database (GAD)
IL32
Human Genome Epidemiology (HuGE) Navigator
IL32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL32
genes like me logo Genes that share disorders with IL32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL32 Gene

Publications for IL32 Gene

  1. Identification of a novel gene expressed in activated natural killer cells and T cells. (PMID: 1729377) Dahl C.A. … Cairns J.S. (J. Immunol. 1992) 2 3 4 22 64
  2. Interleukin-32: a cytokine and inducer of TNFalpha. (PMID: 15664165) Kim S.-H. … Dinarello C.A. (Immunity 2005) 3 4 22 64
  3. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 46 64
  4. Effect of interleukin-32gamma on differentiation of osteoclasts from CD14+ monocytes. (PMID: 20112365) Kim Y.G. … Yoo B. (Arthritis Rheum. 2010) 3 22 64
  5. Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model. (PMID: 20221440) Kobayashi H. … Lin P.C. (PLoS ONE 2010) 3 22 64

Products for IL32 Gene

Sources for IL32 Gene

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