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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL31RA Gene

protein-coding   GIFtS: 52
GCID: GC05P055185

interleukin 31 receptor A

 Explore 17 diseases affiliated with
IL31RA via our new
 Human Malady Compendium 
Biological research products
for IL31RA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 31 Receptor A1 2     GLMR2 5
CRL31 2 3     Glmr1
GLM-R1 2 3     PLCA22
IL-31RA1 2 3     PRO213842
GPL2 3 5     Class I Cytokine Receptor2
CRL1 2     Interleukin-31 Receptor Subunit Alpha2
Cytokine Receptor-Like 32 3     Soluble Type I Cytokine Receptor CRL32
Gp130-Like Monocyte Receptor2 3     ZcytoR173
HGLM-R1     IL-31R-Alpha1
IL-31 Receptor Subunit Alpha2 3     ZcytoR173
IL-31R Subunit Alpha2 3     Gp130-Like Receptor3

External Ids:    HGNC: 189691   Entrez Gene: 1333962   Ensembl: ENSG000001645097   OMIM: 6095105   UniProtKB: Q8NI173   

Export aliases for IL31RA gene to outside databases

Previous GC identifers: GC00U913999 GC05P055165 GC05P052122


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL31RA:
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130,
is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either
as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced
transcript variants encoding different isoforms have been noted for this gene.(provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
Function: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1
and STAT5. May function in skin immunity

Gene Wiki entry for IL31RA


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL31RA gene promoter:
         AP-1   ATF-2   NRSF form 1   Pax-2   STAT5A   NRSF form 2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL31RA promoter sequence
   Search SABiosciences Chromatin IP Primers for IL31RA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL31RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

IL31RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL31RA gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P055185:  view genomic region     (about GC identifiers)

Start:
55,147,207 bp from pter      End:
55,218,678 bp from pter
Size:
71,472 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17 (See protein sequence)
Recommended Name: Interleukin-31 receptor subunit alpha precursor  
Size: 732 amino acids; 82954 Da
Subunit: Heterodimer with OSMR. Interacts with JAK1 and STAT3
Subcellular location: Cell membrane; Single-pass type I membrane protein (Probable)
Sequence caution: Sequence=AAS86444.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAS86445.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NIF8 Q2TBA1 Q6EBC3 Q6EBC4 Q6EBC5 Q6EBC6 Q6UWL8 Q8WYJ0
Alternative splicing: 12 isoforms:  Q8NI17-1   Q8NI17-2   Q8NI17-3   Q8NI17-4   Q8NI17-5   Q8NI17-6   Q8NI17-7   Q8NI17-8   
Q8NI17-9   Q8NI17-10   Q8NI17-11   Q8NI17-12   (Major isoform. Functional IL31 receptor)

Explore the universe of human proteins at neXtProt for IL31RA: NX_Q8NI17

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NI17

  • IL31RA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229565.1  NP_001229566.1  NP_001229567.1  NP_001229568.1  NP_620586.3  

    ENSEMBL proteins: 
     ENSP00000380048   ENSP00000380046   ENSP00000415900   ENSP00000351935   ENSP00000427533  
     ENSP00000347047   ENSP00000297015  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IL31RA

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane NAS11877449


    IL31RA for ontologies           About GeneDecksing



    IL31RA Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL31RA for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015321 IL6_recept-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8NI17

    ProtoNet protein and cluster: Q8NI17

    UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 5 fibronectin type-III domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
    Function: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1
    and STAT5. May function in skin immunity
    Induction: Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG/IFN-gamma
    and bacterial lipopolysaccharides (LPS)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31RA

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS11877449
    GO:0004896cytokine receptor activity TAS11877449
    GO:0019901protein kinase binding NAS11877449
    GO:0019955cytokine binding NAS11877449


    IL31RA for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for IL31RA:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  

    Animal Models:
         Mouse knock-outs for IL31RA: Il31ratm1Lex Il31ratm1Ngh Il31ratm1Jagr
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il31ra):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    IL31RA for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL31RA

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for IL31RA (Q8NI173 ENSP000004159004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6STP401893, ENSP000003387994I2D: score=1 STRING: ENSP00000338799
    LIFRP427023, ENSP000002634094I2D: score=1 STRING: ENSP00000263409
    PIK3C2AO004433I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade NAS11877449
    GO:0006952defense response NAS11877449
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS11877449
    GO:0007259JAK-STAT cascade IEP11877449
    GO:0008284positive regulation of cell proliferation IDA11877449


    IL31RA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL31RA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL31RA
    1 Novoseek chemical compound relationship for IL31RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 64.5 7 15194700 (2), 11877449 (1)

    Search CenterWatch for drugs/clinical trials and news about IL31RA / IL31R 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL31RA gene (5 alternative transcripts): 
    NM_001242636.1  NM_001242637.1  NM_001242638.1  NM_001242639.1  NM_139017.5  

    Unigene Cluster for IL31RA:

    Interleukin 31 receptor A
    Hs.55378  [show with all ESTs]
    Unigene Representative Sequence: NM_001242638
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396836(uc003jqk.3 uc011cqj.2) ENST00000396834(uc003jqm.3 uc003jqn.3 uc010iwa.1)
    ENST00000447346(uc003jql.3 uc021xyq.1 uc003jqo.3) ENST00000359040
    ENST00000490985 ENST00000354961 ENST00000297015

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    Clone
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    Additional cDNA sequence: 

    AF106913.1 AF486620.1 AK297938.1 AY358117.1 AY358740.1 AY499339.1 AY499340.1 AY499341.1 
    AY499342.1 BC110490.2 

    4 DOTS entries:

    DT.95351126  DT.40113745  DT.120874735  DT.120874749 

    17 AceView cDNA sequences:

    BX102881 AY499342 NM_139017 AY358740 AF486620 AY499339 AY499341 AY499340 
    AI123586 BU624025 AY358117 BG680553 AF106913 W16834 AI799583 BG191812 
    BG194774 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL31RA (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18
    SP1:                                                                                      -                             -                                 
    SP2:                          -     -     -                                               -                             -                                 
    SP3:                                                                                      -                       -     -                                 
    SP4:                          -     -     -                                               -                                                               
    SP5:                          -     -     -                                                                                                               


    ECgene alternative splicing isoforms for IL31RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL31RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTTGTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See IL31RA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL31RA

    SOURCE GeneReport for Unigene cluster: Hs.55378

    UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
    Tissue specificity: Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea
    and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14- and CD56-positive blood cells and by
    macrophages (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL31RA: 
              Interferons & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL31RA gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IL31RA1 interleukin 31 receptor A 51.14(n)
    36.8(a)
      427140  XM_424732.2  XP_424732.2 
    lizard
    (Anolis carolinensis)
    Reptilia IL31RA6
    --
    36(a)
    1 ↔ 1
    2(2297101-2315620)
    zebrafish
    (Danio rerio)
    Actinopterygii il6st6
    interleukin 6 signal transducer
    19(a)
    1 → many
    10(7783983-7803832)


    ENSEMBL Gene Tree for IL31RA (if available)
    TreeFam Gene Tree for IL31RA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL31RA gene
    OSMR2  CSF3R2  IL6ST2  IL27RA2  LIFR2  IL12RB22  

    IL31RA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1246 NCBI SNPs in IL31RA are shown (see all 1246    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154839301,2
    F,--55145273(+) TTTTCA/GTTGTT 3 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1480095431,2
    --55145274(+) TTTCAC/TTGTTG 3 -- us2k10--------
    rs665159401,2
    C,--55145512(+) AATATC/ACCTCC 3 -- us2k13Minor allele frequency- A:0.16WA NA 240
    rs1420134471,2
    --55145523(+) TTGAGA/CCTGGC 3 -- us2k10--------
    rs1853642301,2
    --55145529(+) CTGGCA/GTCTGC 3 -- us2k10--------
    rs1458659151,2
    --55145720(+) CTCGAA/GAATGG 3 -- us2k10--------
    rs1392842531,2
    --55145759(+) TGGCAA/TGTTGG 3 -- us2k10--------
    rs789674261,2
    F,--55145783(+) AAGAAC/TGTTGT 3 -- us2k11Minor allele frequency- T:0.02EA 120
    rs68764911,2
    C,F,A,H,--55145935(+) TGATCC/TTTTGT 3 -- us2k129Minor allele frequency- T:0.47NS EA NA WA CSA 3131
    rs680841041,2
    C,--55145961(+) TTCCTA/GTCTGG 3 -- us2k13Minor allele frequency- G:0.13WA NA 240

    HapMap Linkage Disequilibrium report for IL31RA (55147207 - 55218678 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IL31RA
         1 CNV: 6404
    Human Gene Mutation Database (HGMD): IL31RA

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL31RA for disorders           About GeneDecksing

    OMIM gene information: 609510    OMIM disorders: --

    UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
  • Defects in IL31RA are the cause of amyloidosis primary localized cutaneous type 2 (PLCA2) [MIM:613955]. PLCA2
  • is primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with
    itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be
    exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular
    and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis
    characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the
    shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can
    resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented
    macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In
    macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid
    bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of
    degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins

    17 diseases for IL31RA:    About MalaCards
    mycobacterium avium complex disease    phototoxic dermatitis    primary cutaneous amyloidosis    lichen planus
    amyloidosis    systemic lupus erythematosus    atopic dermatitis    antiphospholipid syndrome
    dermatitis    lupus erythematosus    hepatitis b    hepatitis
    schizophrenia    tuberculosis    thyroiditis    leukemia
    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for IL31RA:
    Antiphospholipid syndrome     Mycobacterium avium complex disease     Systemic lupus erythematosus
    Human Genome Epidemiology (HuGE) Navigator: IL31RA (3 documents)

    Export disorders for IL31RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL31RA gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with IL31RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. (PubMed id 11877449)1, 2, 3, 9 Ghilardi N.... De Sauvage F.J. (2002)
    2. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PubMed id 15184896)1, 2, 3 Dillon S.R.... Gross J.A. (2004)
    3. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. (PubMed id 15194700)1, 2, 9 Dreuw A....Hermanns H.M. (2004)
    4. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PubMed id 19690585)1, 2, 9 Lin M.W....Tsai S.F. (2010)
    5. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PubMed id 16461143)1, 2, 9 Bilsborough J.... Gross J.A. (2006)
    6. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. (PubMed id 15627637)1, 2, 9 Diveu C.... Chevalier S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    9. GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor. (PubMed id 14504285)1, 2 Diveu C.... Morel A. (2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 133396 HGNC: 18969 AceView: IL31RA Ensembl:ENSG00000164509 euGenes: HUgn133396
    ECgene: IL31RA H-InvDB: IL31RA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL31RA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL31RA gene:
    Search GeneIP for patents involving IL31RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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