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IL31RA Gene

protein-coding   GIFtS: 58
GCID: GC05P055185

Interleukin 31 Receptor A

  See IL31RA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 31 Receptor A1 2     PLCA22 5
GPL2 3 5     CRL2
Cytokine Receptor-Like 32 3     PRO213842
Gp130-Like Monocyte Receptor2 3     Class I Cytokine Receptor2
CRL32 3     Interleukin-31 Receptor Subunit Alpha2
GLM-R2 3     Soluble Type I Cytokine Receptor CRL32
IL-31RA2 3     zcytoR172
hGLM-R2 3     IL-31R-alpha3
IL-31 Receptor Subunit Alpha2 3     ZcytoR173
IL-31R Subunit Alpha2 3     Gp130-Like Receptor3
GLMR2 5     

External Ids:    HGNC: 189691   Entrez Gene: 1333962   Ensembl: ENSG000001645097   OMIM: 6095105   UniProtKB: Q8NI173   

Export aliases for IL31RA gene to outside databases

Previous GC identifers: GC00U913999 GC05P055165 GC05P052122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL31RA Gene:
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to
gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It
functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several
alternatively spliced transcript variants encoding different isoforms have been noted for this gene.(provided by
RefSeq, Jun 2011)

GeneCards Summary for IL31RA Gene:
IL31RA (interleukin 31 receptor A) is a protein-coding gene. Diseases associated with IL31RA include amyloidosis, primary localized cutaneous, 2, and amyloidosis, primary localized cutaneous, 1. GO annotations related to this gene include cytokine receptor activity and protein kinase binding. An important paralog of this gene is OSMR.

UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
Function: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent
STAT1 and STAT5. May function in skin immunity

Gene Wiki entry for IL31RA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL31RA gene promoter:
         AP-1   ATF-2   NRSF form 1   Pax-2   STAT5A   NRSF form 2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL31RA promoter sequence
   Search Chromatin IP Primers for IL31RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL31RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

IL31RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL31RA gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P055185:  view genomic region     (about GC identifiers)

Start:
55,147,207 bp from pter      End:
55,218,682 bp from pter
Size:
71,476 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17 (See protein sequence)
Recommended Name: Interleukin-31 receptor subunit alpha precursor  
Size: 732 amino acids; 82954 Da
Subunit: Heterodimer with OSMR. Interacts with JAK1 and STAT3
Sequence caution: Sequence=AAS86444.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAS86445.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NIF8 Q2TBA1 Q6EBC3 Q6EBC4 Q6EBC5 Q6EBC6 Q6UWL8 Q8WYJ0
Alternative splicing: 12 isoforms:  Q8NI17-1   Q8NI17-2   Q8NI17-3   Q8NI17-4   Q8NI17-5   Q8NI17-6   Q8NI17-7   Q8NI17-8   
Q8NI17-9   Q8NI17-10   Q8NI17-11   Q8NI17-12   (Major isoform. Functional IL31 receptor)

Explore the universe of human proteins at neXtProt for IL31RA: NX_Q8NI17

Explore proteomics data for IL31RA at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn37, Asn67, Asn93, Asn166, Asn187, Asn277, Asn283, Asn395, Asn455, Asn504
  • Modification sites at PhosphoSitePlus

  • See IL31RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229565.1  NP_001229566.1  NP_001229567.1  NP_001229568.1  NP_620586.3  

    ENSEMBL proteins: 
     ENSP00000380048   ENSP00000380046   ENSP00000415900   ENSP00000351935   ENSP00000427533  
     ENSP00000347047   ENSP00000297015  

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    Cloud-Clone Corp. Proteins for IL31RA

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-31 receptor, alpha subunit
    IL-6 receptor family

    3 InterPro protein domains:
     IPR015321 IL-6_rcpt_alpha-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8NI17

    ProtoNet protein and cluster: Q8NI17

    UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 5 fibronectin type-III domains


    Find genes that share domains with IL31RA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL31R_HUMAN, Q8NI17
    Function: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent
    STAT1 and STAT5. May function in skin immunity
    Induction: Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by
    IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS11877449
    GO:0004896cytokine receptor activity TAS11877449
    GO:0005515protein binding ----
    GO:0019901protein kinase binding NAS11877449
    GO:0019955cytokine binding NAS11877449
         
    Find genes that share ontologies with IL31RA           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for IL31RA:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il31ra):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with IL31RA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL31RA: Il31ratm1Ngh Il31ratm1Jagr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL31RA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL31RA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL31RA

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    miRTarBase miRNAs that target IL31RA:
    hsa-mir-335-5p (MIRT019063)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL31R_HUMAN, Q8NI17: Cell membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane NAS11877449

    Find genes that share ontologies with IL31RA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL31RA: 
              Interferons & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL31RA

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for IL31RA (Q8NI173 ENSP000004159004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6STP401893, ENSP000003387994I2D: score=1 STRING: ENSP00000338799
    LIFRP427023, ENSP000002634094I2D: score=1 STRING: ENSP00000263409
    PIK3C2AO004433I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade NAS11877449
    GO:0006952defense response NAS11877449
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS11877449
    GO:0007259JAK-STAT cascade IEP11877449
    GO:0008284positive regulation of cell proliferation IDA11877449

    Find genes that share ontologies with IL31RA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL31RA (IL31R)

    1 Novoseek inferred chemical compound relationship for IL31RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 64.5 7 15194700 (2), 11877449 (1)



    Find genes that share compounds with IL31RA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL31RA gene (5 alternative transcripts): 
    NM_001242636.1  NM_001242637.1  NM_001242638.1  NM_001242639.1  NM_139017.5  

    Unigene Cluster for IL31RA:

    Interleukin 31 receptor A
    Hs.55378  [show with all ESTs]
    Unigene Representative Sequence: NM_001242638
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396836(uc003jqk.3 uc011cqj.2) ENST00000396834(uc003jqm.3 uc003jqn.3 uc010iwa.1)
    ENST00000447346(uc003jql.3 uc021xyq.1 uc003jqo.3) ENST00000359040
    ENST00000490985 ENST00000354961 ENST00000297015
    miRNA
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    GenScript: all cDNA clones in your preferred vector: IL31RA (NM_139017)
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      QuantiFast Probe-based Assays in human, mouse, rat IL31RA

    Additional mRNA sequence: 

    AF106913.1 AF486620.1 AK297938.1 AY358117.1 AY358740.1 AY499339.1 AY499340.1 AY499341.1 
    AY499342.1 BC110490.2 

    4 DOTS entries:

    DT.95351126  DT.40113745  DT.120874735  DT.120874749 

    17 AceView cDNA sequences:

    BX102881 NM_139017 AF486620 AY499340 AY499341 AY358740 AY499342 AY499339 
    AY358117 BU624025 AI123586 BG680553 AI799583 BG191812 W16834 AF106913 
    BG194774 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL31RA (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18
    SP1:                                                                                      -                             -                                 
    SP2:                          -     -     -                                               -                             -                                 
    SP3:                                                                                      -                       -     -                                 
    SP4:                          -     -     -                                               -                                                               
    SP5:                          -     -     -                                                                                                               


    ECgene alternative splicing isoforms for IL31RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL31RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGTTTT
    IL31RA Expression
    About this image


    IL31RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Bulge Stem Cells Bulge
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
    IL31RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL31RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55378

    UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
    Tissue specificity: Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow,
    trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14- and CD56-positive blood cells
    and by macrophages (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL31RA: 
              Interferons & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL31RA
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    QuantiFast Probe-based Assays in human, mouse, rat IL31RA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL31RA gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il31ra1 , 5 interleukin 31 receptor A1, 5 73.51(n)1
    61.46(a)1
      13 (63.75 cM)5
    2186241  NM_139299.21  NP_647460.21 
     1125228105 
    chicken
    (Gallus gallus)
    Aves IL31RA1 interleukin 31 receptor A 52.54(n)
    38.66(a)
      427140  XM_004937245.1  XP_004937302.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL31RA6
    interleukin 31 receptor A
    33(a)
    1 ↔ 1
    2(2295845-2321527)
    zebrafish
    (Danio rerio)
    Actinopterygii il12rb2l6
    interleukin 12 receptor, beta 2a, like
    14(a)
    many ↔ many
    3(19038465-19064947) ENSDARG00000074850


    ENSEMBL Gene Tree for IL31RA (if available)
    TreeFam Gene Tree for IL31RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL31RA gene
    OSMR2  IL6ST2  CSF3R2  LIFR2  IL12RB22  

    Find genes that share paralogs with IL31RA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL31RA (see all 1455)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0658094
    Amyloidosis, primary localized cutaneous, 2 (PLCA2)4--see VAR_0658092 S F mis40--------
    rs1154839301,2
    C,F--55082932(+) TTTTCA/GTTGTT 3 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1480095431,2
    --55082933(+) TTTCAC/TTGTTG 3 -- us2k10--------
    rs665159401,2
    C,F--55083171(+) AATATC/ACCTCC 3 -- us2k13Minor allele frequency- A:0.16WA NA 240
    rs1420134471,2
    --55083182(+) TTGAGA/CCTGGC 3 -- us2k10--------
    rs1853642301,2
    --55083188(+) CTGGCA/GTCTGC 3 -- us2k10--------
    rs1458659151,2
    --55083379(+) CTCGAA/GAATGG 3 -- us2k10--------
    rs1392842531,2
    --55083418(+) TGGCAA/TGTTGG 3 -- us2k10--------
    rs789674261,2
    C,F--55083442(+) AAGAAC/TGTTGT 3 -- us2k11Minor allele frequency- T:0.02EA 120
    rs68764911,2
    C,F,A,H--55083594(+) tgatcC/Ttttgt 3 -- us2k129Minor allele frequency- T:0.47NS EA NA WA CSA 3131

    HapMap Linkage Disequilibrium report for IL31RA (55147207 - 55218682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IL31RA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271365CNV Insertion20981092
    esv273498CNV Insertion20981092
    nsv881699CNV Loss21882294
    nsv327714CNV Loss16902084
    nsv524739CNV Loss19592680
    nsv830307CNV Gain17160897

    Human Gene Mutation Database (HGMD): IL31RA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL31RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL31RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609510   
    OMIM disorders: 613955  
    UniProtKB/Swiss-Prot: IL31R_HUMAN, Q8NI17
  • Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by
    localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower
    legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching
    and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although
    many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as
    a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa
    of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen
    simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to
    produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen
    amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to
    represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate
    keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 5 diseases for IL31RA:    
    About MalaCards
    amyloidosis, primary localized cutaneous, 2    amyloidosis, primary localized cutaneous, 1    mycobacterium avium complex disease    primary cutaneous amyloidosis
    amyloidosis

    3 diseases from the University of Copenhagen DISEASES database for IL31RA:
    Antiphospholipid syndrome     Mycobacterium avium complex disease     Lupus erythematosus

    Find genes that share disorders with IL31RA           About GenesLikeMe

    Genetic Association Database (GAD): IL31RA
    Human Genome Epidemiology (HuGE) Navigator: IL31RA (3 documents)

    Export disorders for IL31RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL31RA gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with IL31RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. (PubMed id 11877449)1, 2, 3, 9 Ghilardi N.... De Sauvage F.J. (J. Biol. Chem. 2002)
    2. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PubMed id 15184896)1, 2, 3 Dillon S.R.... Gross J.A. (Nat. Immunol. 2004)
    3. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. (PubMed id 15194700)1, 2, 9 Dreuw A....Hermanns H.M. (J. Biol. Chem. 2004)
    4. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PubMed id 19690585)1, 2, 9 Lin M.W.... Tsai S.F. (Eur. J. Hum. Genet. 2010)
    5. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PubMed id 16461143)1, 2, 9 Bilsborough J.... Gross J.A. (J. Allergy Clin. Immunol. 2006)
    6. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. (PubMed id 15627637)1, 2, 9 Diveu C.... Chevalier S. (Eur. Cytokine Netw. 2004)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 133396 HGNC: 18969 AceView: IL31RA Ensembl:ENSG00000164509 euGenes: HUgn133396
    ECgene: IL31RA H-InvDB: IL31RA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL31RA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL31RA gene:
    Search GeneIP for patents involving IL31RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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