Aliases for IL31RA Gene
External Ids for IL31RA Gene
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
GeneCards Summary for IL31RA Gene
IL31RA (Interleukin 31 Receptor A) is a Protein Coding gene. Diseases associated with IL31RA include amyloidosis, primary localized cutaneous, 2 and primary cutaneous amyloidosis. GO annotations related to this gene include protein kinase binding and cytokine receptor activity. An important paralog of this gene is CSF3R.
UniProtKB/Swiss-Prot for IL31RA Gene
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.