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Aliases for IL31RA Gene

Aliases for IL31RA Gene

  • Interleukin 31 Receptor A 2 3 5
  • Gp130-Like Monocyte Receptor 3 4
  • IL-31 Receptor Subunit Alpha 3 4
  • Cytokine Receptor-Like 3 3 4
  • IL-31R Subunit Alpha 3 4
  • ZcytoR17 3 4
  • IL-31RA 3 4
  • HGLM-R 3 4
  • GLM-R 3 4
  • CRL3 3 4
  • GPL 3 4
  • Soluble Type I Cytokine Receptor CRL3 3
  • Class I Cytokine Receptor 3
  • Gp130-Like Receptor 4
  • IL-31R-Alpha 4
  • PRO21384 3
  • PLCA2 3
  • GLMR 3
  • CRL 3

External Ids for IL31RA Gene

Previous GeneCards Identifiers for IL31RA Gene

  • GC00U913999
  • GC05P055165
  • GC05P055185
  • GC05P052122
  • GC05P055851

Summaries for IL31RA Gene

Entrez Gene Summary for IL31RA Gene

  • The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for IL31RA Gene

IL31RA (Interleukin 31 Receptor A) is a Protein Coding gene. Diseases associated with IL31RA include Amyloidosis, Primary Localized Cutaneous, 2 and Primary Cutaneous Amyloidosis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and cytokine receptor activity. An important paralog of this gene is CSF3R.

UniProtKB/Swiss-Prot for IL31RA Gene

  • Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.

Gene Wiki entry for IL31RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL31RA Gene

Genomics for IL31RA Gene

Regulatory Elements for IL31RA Gene

Genomic Location for IL31RA Gene

55,840,334 bp from pter
55,922,854 bp from pter
82,521 bases
Plus strand

Genomic View for IL31RA Gene

Genes around IL31RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL31RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL31RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL31RA Gene

Proteins for IL31RA Gene

  • Protein details for IL31RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-31 receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • A6NIF8
    • Q2TBA1
    • Q6EBC3
    • Q6EBC4
    • Q6EBC5
    • Q6EBC6
    • Q6UWL8
    • Q8WYJ0

    Protein attributes for IL31RA Gene

    732 amino acids
    Molecular mass:
    82954 Da
    Quaternary structure:
    • Heterodimer with OSMR. Interacts with JAK1 and STAT3.
    • Sequence=AAS86444.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAS86445.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL31RA Gene

neXtProt entry for IL31RA Gene

Proteomics data for IL31RA Gene at MOPED

Post-translational modifications for IL31RA Gene

  • N-glycosylated.
  • Glycosylation at Asn 37, Asn 67, Asn 93, Asn 166, Asn 187, Asn 277, Asn 283, Asn 395, Asn 455, and Asn 504
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for IL31RA

No data available for DME Specific Peptides for IL31RA Gene

Domains & Families for IL31RA Gene

Protein Domains for IL31RA Gene

Suggested Antigen Peptide Sequences for IL31RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
  • Contains 5 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with IL31RA: view

Function for IL31RA Gene

Molecular function for IL31RA Gene

UniProtKB/Swiss-Prot Function:
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS).
genes like me logo Genes that share phenotypes with IL31RA: view

Human Phenotype Ontology for IL31RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL31RA Gene

MGI Knock Outs for IL31RA:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL31RA

miRNA for IL31RA Gene

miRTarBase miRNAs that target IL31RA

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IL31RA Gene

Localization for IL31RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL31RA Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL31RA Gene COMPARTMENTS Subcellular localization image for IL31RA gene
Compartment Confidence
plasma membrane 4
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IL31RA Gene

Pathways & Interactions for IL31RA Gene

genes like me logo Genes that share pathways with IL31RA: view

Pathways by source for IL31RA Gene

Interacting Proteins for IL31RA Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000415900 Q8NI17-IL31R_HUMAN for IL31RA Gene via STRING I2D

SIGNOR curated interactions for IL31RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL31RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002067 glandular epithelial cell differentiation IEA --
GO:0008284 positive regulation of cell proliferation IDA 11877449
GO:0019221 cytokine-mediated signaling pathway TAS 11877449
GO:0035745 T-helper 2 cell cytokine production IEA --
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein IEP 11877449
genes like me logo Genes that share ontologies with IL31RA: view

Drugs & Compounds for IL31RA Gene

(1) Additional Compounds for IL31RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL31RA: view

Transcripts for IL31RA Gene

Unigene Clusters for IL31RA Gene

Interleukin 31 receptor A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL31RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for IL31RA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL31RA Gene

mRNA expression in normal human tissues for IL31RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL31RA Gene

This gene is overexpressed in Artery - Aorta (x12.6), Testis (x6.6), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Skin - Sun Exposed (Lower leg) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for IL31RA Gene

SOURCE GeneReport for Unigene cluster for IL31RA Gene Hs.55378

mRNA Expression by UniProt/SwissProt for IL31RA Gene

Tissue specificity: Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14- and CD56-positive blood cells and by macrophages (at protein level).
genes like me logo Genes that share expression patterns with IL31RA: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for IL31RA Gene

Orthologs for IL31RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL31RA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL31RA 35
  • 81.17 (n)
  • 71.13 (a)
IL31RA 36
  • 69 (a)
(Canis familiaris)
Mammalia IL31RA 35
  • 82.7 (n)
  • 72.36 (a)
IL31RA 36
  • 72 (a)
(Mus musculus)
Mammalia Il31ra 35
  • 73.51 (n)
  • 61.46 (a)
Il31ra 16
Il31ra 36
  • 60 (a)
(Pan troglodytes)
Mammalia IL31RA 35
  • 99.11 (n)
  • 98.39 (a)
IL31RA 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Il31ra 35
  • 73.14 (n)
  • 60.06 (a)
(Monodelphis domestica)
Mammalia IL31RA 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
(Gallus gallus)
Aves IL31RA 35
  • 52.54 (n)
  • 38.66 (a)
(Anolis carolinensis)
Reptilia IL31RA 36
  • 33 (a)
(Danio rerio)
Actinopterygii il12rb2l 36
  • 14 (a)
Species with no ortholog for IL31RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL31RA Gene

Gene Tree for IL31RA (if available)
Gene Tree for IL31RA (if available)

Paralogs for IL31RA Gene

Paralogs for IL31RA Gene

genes like me logo Genes that share paralogs with IL31RA: view

Variants for IL31RA Gene

Sequence variations from dbSNP and Humsavar for IL31RA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs13184107 - 55,883,148(+) CATCT(A/G)ATTTA reference, missense
rs161704 - 55,910,616(-) TGGTG(C/T)TGGCC reference, missense
VAR_065809 Amyloidosis, primary localized cutaneous, 2 (PLCA2)
rs918626 -- 55,886,113(+) TCTTT(A/G)ACAAA intron-variant
rs931095 -- 55,888,640(-) CCCAA(A/C)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL31RA Gene

Variant ID Type Subtype PubMed ID
nsv881699 CNV Loss 21882294
nsv830307 CNV Gain 17160897
esv271365 CNV Insertion 20981092
esv273498 CNV Insertion 20981092
nsv524739 CNV Loss 19592680
nsv327714 CNV Loss 16902084

Variation tolerance for IL31RA Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.84; 86.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL31RA Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL31RA Gene

Disorders for IL31RA Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL31RA Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis, primary localized cutaneous, 2
  • plca2
primary cutaneous amyloidosis
  • familial primary localized cutaneous amyloidosis
lichen amyloidosis
  • amyloidosis, primary cutaneous
macular amyloidosis
  • amyloidosis, macular
mycobacterium avium complex disease
  • infection due to mycobacterium intracellulare
- elite association - COSMIC cancer census association via MalaCards


  • Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269 PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL31RA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL31RA: view

No data available for Genatlas for IL31RA Gene

Publications for IL31RA Gene

  1. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. (PMID: 11877449) Ghilardi N. … De Sauvage F.J. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PMID: 19690585) Lin M.W. … Tsai S.F. (Eur. J. Hum. Genet. 2010) 3 23
  3. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PMID: 16461143) Bilsborough J. … Gross J.A. (J. Allergy Clin. Immunol. 2006) 3 23
  4. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PMID: 15184896) Dillon S.R. … Gross J.A. (Nat. Immunol. 2004) 2 3
  5. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. (PMID: 15194700) Dreuw A. … Hermanns H.M. (J. Biol. Chem. 2004) 3 23

Products for IL31RA Gene

Sources for IL31RA Gene