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Aliases for IL31RA Gene

Aliases for IL31RA Gene

  • Interleukin 31 Receptor A 2 3 5
  • Gp130-Like Monocyte Receptor 3 4
  • IL-31 Receptor Subunit Alpha 3 4
  • Cytokine Receptor-Like 3 3 4
  • IL-31R Subunit Alpha 3 4
  • ZcytoR17 3 4
  • IL-31RA 3 4
  • HGLM-R 3 4
  • GLM-R 3 4
  • CRL3 3 4
  • GPL 3 4
  • Interleukin-31 Receptor Subunit Alpha 3
  • Soluble Type I Cytokine Receptor CRL3 3
  • Class I Cytokine Receptor 3
  • Gp130-Like Receptor 4
  • IL-31R-Alpha 4
  • PRO21384 3
  • PLCA2 3
  • GLMR 3
  • CRL 3

External Ids for IL31RA Gene

Previous GeneCards Identifiers for IL31RA Gene

  • GC00U913999
  • GC05P055165
  • GC05P055185
  • GC05P052122
  • GC05P055851

Summaries for IL31RA Gene

Entrez Gene Summary for IL31RA Gene

  • The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for IL31RA Gene

IL31RA (Interleukin 31 Receptor A) is a Protein Coding gene. Diseases associated with IL31RA include Amyloidosis, Primary Localized Cutaneous, 2 and Primary Cutaneous Amyloidosis. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Immune System. GO annotations related to this gene include protein kinase binding and cytokine receptor activity. An important paralog of this gene is IL6ST.

UniProtKB/Swiss-Prot for IL31RA Gene

  • Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).

Gene Wiki entry for IL31RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL31RA Gene

Genomics for IL31RA Gene

Regulatory Elements for IL31RA Gene

Enhancers for IL31RA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IL31RA on UCSC Golden Path with GeneCards custom track

Genomic Location for IL31RA Gene

Chromosome:
5
Start:
55,840,334 bp from pter
End:
55,922,854 bp from pter
Size:
82,521 bases
Orientation:
Plus strand

Genomic View for IL31RA Gene

Genes around IL31RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL31RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL31RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL31RA Gene

Proteins for IL31RA Gene

  • Protein details for IL31RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI17-IL31R_HUMAN
    Recommended name:
    Interleukin-31 receptor subunit alpha
    Protein Accession:
    Q8NI17
    Secondary Accessions:
    • A6NIF8
    • Q2TBA1
    • Q6EBC3
    • Q6EBC4
    • Q6EBC5
    • Q6EBC6
    • Q6UWL8
    • Q8WYJ0

    Protein attributes for IL31RA Gene

    Size:
    732 amino acids
    Molecular mass:
    82954 Da
    Quaternary structure:
    • Heterodimer with OSMR. Interacts with JAK1 and STAT3.
    SequenceCaution:
    • Sequence=AAS86444.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAS86445.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL31RA Gene

neXtProt entry for IL31RA Gene

Post-translational modifications for IL31RA Gene

  • N-glycosylated.
  • Glycosylation at Asn 37, Asn 67, Asn 93, Asn 166, Asn 187, Asn 277, Asn 283, Asn 395, Asn 455, and Asn 504
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for IL31RA

No data available for DME Specific Peptides for IL31RA Gene

Domains & Families for IL31RA Gene

Protein Domains for IL31RA Gene

Suggested Antigen Peptide Sequences for IL31RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI17

UniProtKB/Swiss-Prot:

IL31R_HUMAN :
  • Contains 5 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
Domain:
  • Contains 5 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with IL31RA: view

Function for IL31RA Gene

Molecular function for IL31RA Gene

UniProtKB/Swiss-Prot Function:
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in lesional keratinocytes of patients with atopic dermatitis (PubMed:16461143). Up-regulated by IFNG/IFN-gamma (PubMed:11877449, PubMed:14504285, PubMed:15184896, PubMed:21261663, PubMed:18439099). Up-regulated by bacterial lipopolysaccharides (LPS) (PubMed:11877449, PubMed:15184896, PubMed:14504285). Up-regulated by triacylated lipoprotein (Pam3Cys) (PubMed:21261663). Up-regulated by TGFB1/TGF-beta (PubMed:18439099).

Gene Ontology (GO) - Molecular Function for IL31RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 11877449
GO:0004896 cytokine receptor activity TAS 11877449
GO:0019901 protein kinase binding NAS 11877449
GO:0019955 cytokine binding NAS 11877449
genes like me logo Genes that share ontologies with IL31RA: view
genes like me logo Genes that share phenotypes with IL31RA: view

Human Phenotype Ontology for IL31RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL31RA Gene

MGI Knock Outs for IL31RA:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL31RA

CRISPR Products

miRNA for IL31RA Gene

miRTarBase miRNAs that target IL31RA

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL31RA Gene

Localization for IL31RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL31RA Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL31RA Gene COMPARTMENTS Subcellular localization image for IL31RA gene
Compartment Confidence
plasma membrane 4
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL31RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane NAS 11877449
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with IL31RA: view

Pathways & Interactions for IL31RA Gene

genes like me logo Genes that share pathways with IL31RA: view

Pathways by source for IL31RA Gene

Interacting Proteins for IL31RA Gene

SIGNOR curated interactions for IL31RA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL31RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade NAS 11877449
GO:0002067 glandular epithelial cell differentiation IEA --
GO:0002438 acute inflammatory response to antigenic stimulus IEA --
GO:0006952 defense response NAS 11877449
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 11877449
genes like me logo Genes that share ontologies with IL31RA: view

Drugs & Compounds for IL31RA Gene

(1) Additional Compounds for IL31RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL31RA: view

Transcripts for IL31RA Gene

Unigene Clusters for IL31RA Gene

Interleukin 31 receptor A:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL31RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for IL31RA Gene

GeneLoc Exon Structure for
IL31RA
ECgene alternative splicing isoforms for
IL31RA

Expression for IL31RA Gene

mRNA expression in normal human tissues for IL31RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL31RA Gene

This gene is overexpressed in Artery - Aorta (x12.6), Testis (x6.6), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Skin - Sun Exposed (Lower leg) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL31RA Gene



NURSA nuclear receptor signaling pathways regulating expression of IL31RA Gene:

IL31RA

SOURCE GeneReport for Unigene cluster for IL31RA Gene:

Hs.55378

mRNA Expression by UniProt/SwissProt for IL31RA Gene:

Q8NI17-IL31R_HUMAN
Tissue specificity: Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353).
genes like me logo Genes that share expression patterns with IL31RA: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for IL31RA Gene

Orthologs for IL31RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL31RA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL31RA 34
  • 81.17 (n)
  • 71.13 (a)
IL31RA 35
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL31RA 34
  • 82.7 (n)
  • 72.36 (a)
IL31RA 35
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il31ra 34
  • 73.51 (n)
  • 61.46 (a)
Il31ra 16
Il31ra 35
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL31RA 34
  • 99.11 (n)
  • 98.39 (a)
IL31RA 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il31ra 34
  • 73.14 (n)
  • 60.06 (a)
oppossum
(Monodelphis domestica)
Mammalia IL31RA 35
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 12 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IL31RA 34
  • 52.54 (n)
  • 38.66 (a)
lizard
(Anolis carolinensis)
Reptilia IL31RA 35
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il12rb2l 35
  • 14 (a)
ManyToMany
Species where no ortholog for IL31RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL31RA Gene

ENSEMBL:
Gene Tree for IL31RA (if available)
TreeFam:
Gene Tree for IL31RA (if available)

Paralogs for IL31RA Gene

Paralogs for IL31RA Gene

genes like me logo Genes that share paralogs with IL31RA: view

Variants for IL31RA Gene

Sequence variations from dbSNP and Humsavar for IL31RA Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs13184107 - 55,883,148(+) CATCT(A/G)ATTTA reference, missense
rs161704 - 55,910,616(-) TGGTG(C/T)TGGCC reference, missense
VAR_065809 Amyloidosis, primary localized cutaneous, 2 (PLCA2)
rs161648 -- 55,893,956(-) CACAC(A/G)CCTGT intron-variant
rs161649 -- 55,894,202(-) CTCAC(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL31RA Gene

Variant ID Type Subtype PubMed ID
nsv1073883 CNV deletion 25765185
nsv1109698 CNV deletion 24896259
nsv1119033 CNV deletion 24896259
nsv327714 CNV deletion 16902084
nsv474741 CNV novel sequence insertion 20440878
nsv524739 CNV loss 19592680
nsv830307 CNV gain 17160897
nsv950061 CNV deletion 24416366

Variation tolerance for IL31RA Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.84; 86.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL31RA Gene

Human Gene Mutation Database (HGMD)
IL31RA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL31RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL31RA Gene

Disorders for IL31RA Gene

MalaCards: The human disease database

(9) MalaCards diseases for IL31RA Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis, primary localized cutaneous, 2
  • plca2
primary cutaneous amyloidosis
  • familial primary localized cutaneous amyloidosis
atopic dermatitis
  • eczema
dermatitis
  • eczema
lichen amyloidosis
  • amyloid lichen
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

IL31R_HUMAN
  • Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269 PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL31RA

Genetic Association Database (GAD)
IL31RA
Human Genome Epidemiology (HuGE) Navigator
IL31RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL31RA
genes like me logo Genes that share disorders with IL31RA: view

No data available for Genatlas for IL31RA Gene

Publications for IL31RA Gene

  1. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. (PMID: 11877449) Ghilardi N. … De Sauvage F.J. (J. Biol. Chem. 2002) 2 3 4 22 65
  2. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. (PMID: 19690585) Lin M.W. … Tsai S.F. (Eur. J. Hum. Genet. 2010) 3 4 22 65
  3. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PMID: 16461143) Bilsborough J. … Gross J.A. (J. Allergy Clin. Immunol. 2006) 3 4 22 65
  4. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PMID: 15184896) Dillon S.R. … Gross J.A. (Nat. Immunol. 2004) 2 3 4 65
  5. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. (PMID: 15194700) Dreuw A. … Hermanns H.M. (J. Biol. Chem. 2004) 3 4 22 65

Products for IL31RA Gene

Sources for IL31RA Gene

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