IL31 Gene
protein-coding GIFtS: 41
GCID: GC12M122656
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|
interleukin 31
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Aliases
for IL31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 311 2 | | IL-311 2 3 | | Interleukin-311 |
Export aliases for IL31 gene to outside databasesPrevious GC identifers: GC00U914001 GC12U900495 GC12M121222 GC12M119617 |
Summaries
for IL31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL31:
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting ofIL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma(Dillon et al., 2004 (PubMed 15184896)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA andOSMR. IL31 may function in skin immunity
Gene Wiki entry for IL31 (Interleukin 31)
|
Genomic Views
for IL31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL31 gene promoter:
STAT1 AP-1 ATF-2 STAT1beta STAT5A STAT1alpha HFH-1 STAT3 FOXJ2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL31
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL31 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31IL31 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M122656: view genomic region
(about GC identifiers)
Start:
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122,656,577 bp from pter |
End:
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122,658,746 bp from pter |
Size:
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2,170 bases |
Orientation:
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minus strand |
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Proteins
for IL31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2 (See
protein sequence)Recommended Name: Interleukin-31 precursor Size: 164 amino acids; 18205 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A2RUQ1Explore the universe of human proteins at neXtProt for IL31: NX_Q6EBC2
IL31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001014358.1
ENSEMBL proteins: ENSP00000366234
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- |
IL31 for ontologies About GeneDecksing
IL31 Antibody Products:
Assay Products for IL31: |
Protein
Domains /
Families
for IL31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6EBC2 |
Function
for IL31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA andOSMR. IL31 may function in skin immunityInduction: Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulatingT-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL31 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL31
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for IL31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL31 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- |
IL31 for ontologies About GeneDecksing
|
Pathways & Interactions
for IL31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL31
|
Drugs & Compounds
for IL31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IL31 for compounds About GeneDecksing
 Browse Tocris compounds for IL31
2 Novoseek chemical compound relationships for IL31 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gp 130 |
68 |
3 |
17028186 (1), 18926762 (1), 17148439 (1) |
| histamine |
28.9 |
1 |
19196660 (1) |
Search CenterWatch for drugs/clinical trials and news about IL31
|
Transcripts
for IL31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL31 gene: NM_001014336.1 Unigene Cluster for IL31: Interleukin 31 Hs.569071 Unigene Representative Sequence: AY4993431 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000377035(uc001ubv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL31 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL31
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IL31 (NM_139017) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL31 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL31 |
Additional cDNA sequence: AY499343.1 BC132998.1 BC133000.1 1 DOTS entry: DT.121214298
GeneLoc Exon Structure
|
Expression
for IL31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL31 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTCGCAC
About this image
See IL31 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.569071
UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2Tissue specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, smallintestine and trachea
SABiosciences Expression via Pathway-Focused PCR Arrays including IL31: | T-Cell Anergy & Immune Tolerance in human mouse rat | | Allergy & Asthma in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL31
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL31 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31 |
Orthologs
for IL31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for IL31 gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Il315 |
interleukin 31 |
-- |
|
5 (63.00 cM) 123480153 |
ENSEMBL Gene Tree for IL31 (if available)
TreeFam Gene Tree for IL31 (if available) |
Paralogs
for IL31 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL31 |
|
Disorders
/ Diseases
for IL31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL31 for disorders About GeneDecksing
OMIM gene information: 609509
OMIM disorders: --
18  diseases for IL31: About MalaCardsepidermolysis bullosa pruriginosa epidermolysis bullosa asthma allergic contact dermatitis
contact dermatitis primary cutaneous amyloidosis dermatitis allergic rhinitis
inflammatory bowel disease atopic dermatitis eczema myeloproliferative disorder
amyloidosis skin disease rhinitis urticaria
psoriasis atopy
2 diseases from the University of Copenhagen DISEASES database for IL31:Atopic dermatitis Primary cutaneous amyloidosis 9 Novoseek disease relationships for IL31 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dermatitis atopic |
69.2 |
20 |
15925362 (3), 16461143 (2), 16461142 (2), 18606082 (1) (see all 9) |
| dermatitis |
64.2 |
13 |
16461142 (4), 16461143 (2), 17030248 (1), 17627770 (1) (see all 6) |
| eczema |
51 |
8 |
17900679 (6), 15635736 (1), 17030248 (1) |
| psoriasis |
36.6 |
2 |
17030248 (1), 16461143 (1) |
| skin diseases |
35.2 |
4 |
17030248 (2), 16461142 (2) |
| glioblastoma |
31.2 |
1 |
15627637 (1) |
| inflammation |
6.66 |
4 |
16569341 (1), 17449633 (1), 18179886 (1), 17627770 (1) |
| melanoma |
5.3 |
1 |
15627637 (1) |
| tumors |
0 |
1 |
15627637 (1) |
Human Genome Epidemiology (HuGE) Navigator: IL31 (2 documents)
Export disorders for IL31 gene to outside databases
|
Publications
for IL31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL31 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with IL31) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PubMed id 15184896)1, 2, 3 Dillon S.R.... Gross J.A. (2004)
- Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. (PubMed id 17030248)1, 2, 9 Neis M.M....Hermanns H.M. (2006)
- IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PubMed id 16461143)1, 2, 9 Bilsborough J.... Gross J.A. (2006)
- IL-31: a new link between T cells and pruritus in atopic skin inflammation. (PubMed id 16461142)1, 9 Sonkoly E....Homey B. (2006)
- A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. (PubMed id 17900679)1, 9 Schulz F....Lee Y.A. (2007)
- Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. (PubMed id 15925362)1, 9 Takaoka A....Nakaike S. (2005)
- The histamine H4 receptor is functionally expressed on T(H)2 cells. (PubMed id 19281909)1, 9 Gutzmer R....Werfel T. (2009)
- Interleukin-31 stimulates production of inflammatory mediators from human colonic subepithelial myofibroblasts. (PubMed id 17487427)1, 9 Yagi Y....Fujiyama Y. (2007)
- Structures and biological functions of IL-31 and IL-31 receptors. (PubMed id 18926762)1, 9 Zhang Q....Gao W. (2008)
- Regulated expression of the IL-31 receptor in bronchial and alveolar epithelial cells, pulmonary fibroblasts, and pulmonary macrophages. (PubMed id 18439099)1, 9 Jawa R.S....Baumann H. (2008)
|
External Searches for IL31 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL31 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IL31 gene:
Search GeneIP for patents involving IL31
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL31 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL31 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL31 | | | OriGene Protein Over-expression Lysate for IL31 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL31 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL31 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL31 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL31 | | OriGene Custom Protein Services for IL31 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL31 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL31 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL31 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL31 |
| |
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| | | | Search Tocris compounds for IL31 |
| |  |  |  |  | | | | | | Recombinant Protein for IL31 |
|
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 | | | IL31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31 |
|  |  |  | | | | ThermoFisher Antibody for IL31 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL31 |
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