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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL31 Gene

protein-coding   GIFtS: 42
GCID: GC12M122656

Interleukin 31

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 311 2
IL-312 3
interleukin-312

External Ids:    HGNC: 193721   Entrez Gene: 3866532   Ensembl: ENSG000002046717   OMIM: 6095095   UniProtKB: Q6EBC23   

Export aliases for IL31 gene to outside databases

Previous GC identifers: GC00U914001 GC12U900495 GC12M121222 GC12M119617


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL31 Gene:
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting
of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and
keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic
diseases, such as asthma (Dillon et al., 2004 (PubMed 15184896)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IL31 Gene: 
IL31 (interleukin 31) is a protein-coding gene. Diseases associated with IL31 include epidermolysis bullosa pruriginosa, and contact dermatitis. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2
Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA
and OSMR. IL31 may function in skin immunity

Gene Wiki entry for IL31 (Interleukin 31) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL31 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   STAT5A   STAT1alpha   HFH-1   STAT3   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL31 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL31

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

IL31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL31 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122656:  view genomic region     (about GC identifiers)

Start:
122,656,577 bp from pter      End:
122,658,746 bp from pter
Size:
2,170 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2 (See protein sequence)
Recommended Name: Interleukin-31 precursor  
Size: 164 amino acids; 18205 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A2RUQ1

Explore the universe of human proteins at neXtProt for IL31: NX_Q6EBC2

Explore proteomics data for IL31 at MOPED 

IL31 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL31 Protein Expression

REFSEQ proteins: NP_001014358.1  
ENSEMBL proteins: 
 ENSP00000366234  

Human Recombinant Protein Products for IL31: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

IL31 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

ProtoNet protein and cluster: Q6EBC2


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL31_HUMAN, Q6EBC2
Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA
and OSMR. IL31 may function in skin immunity
Induction: Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated
circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
IL31 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL31

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL31 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for IL31

2 Novoseek inferred chemical compound relationships for IL31 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130 68 3 17028186 (1), 18926762 (1), 17148439 (1)
histamine 28.9 1 19196660 (1)

Search CenterWatch for drugs/clinical trials and news about IL31

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IL31 gene: 
NM_001014336.1  

Unigene Cluster for IL31:

Interleukin 31
Hs.569071
Unigene Representative Sequence: AY499343
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000377035(uc001ubv.3)
miRNA
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Additional mRNA sequence: 

AY499343.1 BC132998.1 BC133000.1 

1 DOTS entry:

DT.121214298 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL31 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACCTCGCAC
IL31 Expression
About this image


See IL31 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.569071

UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2
Tissue specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small
intestine and trachea

    SABiosciences Expression via Pathway-Focused PCR Arrays including IL31: 
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          Allergy & Asthma in human mouse rat

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL31 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il315 interleukin 31   --   5 (63.00 cM) 123480153 


ENSEMBL Gene Tree for IL31 (if available)
TreeFam Gene Tree for IL31 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL31
DNA2.0 Custom Variant and Variant Library Synthesis for IL31

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609509    OMIM disorders: --

17 diseases for IL31:    About MalaCards
epidermolysis bullosa pruriginosa    contact dermatitis    allergic contact dermatitis    primary cutaneous amyloidosis
atopic dermatitis    eczema    skin disease    dermatitis
epidermolysis bullosa    asthma    amyloidosis    urticaria
psoriasis    atopy    allergic rhinitis    rhinitis
inflammatory bowel disease

2 diseases from the University of Copenhagen DISEASES database for IL31:
Atopic dermatitis     Primary cutaneous amyloidosis

IL31 for disorders           About GeneDecksing

9 Novoseek inferred disease relationships for IL31 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
dermatitis atopic 69.2 20 15925362 (3), 16461143 (2), 16461142 (2), 18606082 (1) (see all 9)
dermatitis 64.2 13 16461142 (4), 16461143 (2), 17030248 (1), 17627770 (1) (see all 6)
eczema 51 8 17900679 (6), 15635736 (1), 17030248 (1)
psoriasis 36.6 2 17030248 (1), 16461143 (1)
skin diseases 35.2 4 17030248 (2), 16461142 (2)
glioblastoma 31.2 1 15627637 (1)
inflammation 6.66 4 16569341 (1), 17449633 (1), 18179886 (1), 17627770 (1)
melanoma 5.3 1 15627637 (1)
tumors 0 1 15627637 (1)

Genetic Association Database (GAD): IL31
Human Genome Epidemiology (HuGE) Navigator: IL31 (2 documents)

Export disorders for IL31 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL31 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with IL31)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PubMed id 15184896)1, 2, 3 Dillon S.R.... Gross J.A. (2004)
  2. Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. (PubMed id 17030248)1, 2, 9 Neis M.M....Hermanns H.M. (2006)
  3. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PubMed id 16461143)1, 2, 9 Bilsborough J.... Gross J.A. (2006)
  4. A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. (PubMed id 17900679)1, 4, 9 Schulz F....Lee Y.A. (2007)
  5. Common IL-31 gene haplotype associated with non-atopi c eczema is not implicated in epidermolysis bullosa pruriginosa. (PubMed id 21057749)1, 4 Nagy N....McGrath J.A. (2010)
  6. IL-31: a new link between T cells and pruritus in atopic skin inflammation. (PubMed id 16461142)1, 9 Sonkoly E....Homey B. (2006)
  7. Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. (PubMed id 15925362)1, 9 Takaoka A....Nakaike S. (2005)
  8. The histamine H4 receptor is functionally expressed on T(H)2 cells. (PubMed id 19281909)1, 9 Gutzmer R....Werfel T. (2009)
  9. Interleukin-31 stimulates production of inflammatory mediators from human colonic subepithelial myofibroblasts. (PubMed id 17487427)1, 9 Yagi Y....Fujiyama Y. (2007)
  10. Structures and biological functions of IL-31 and IL-31 receptors. (PubMed id 18926762)1, 9 Zhang Q....Gao W. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 386653 HGNC: 19372 Ensembl:ENSG00000204671 euGenes: HUgn386653 ECgene: IL31
H-InvDB: IL31

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL31 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IL31 gene:
Search GeneIP for patents involving IL31

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31
 SwitchGear 3'UTR luciferase reporter plasmids for IL31
 SwitchGear Promoter luciferase reporter plasmids for IL31
 ThermoFisher Antibody for IL31
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL31
 inGenious Targeting Laboratory - Custom generated mouse model solutions for IL31
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL31
Customized:
 lentivirus for stable overexpression of IL31
 lentivirus expression plasmids for stable overexpression of IL31
 adenovirus for overexpression of IL31
 LSBio Antibodies in human, mouse, rat for IL31
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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