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IL31 Gene

protein-coding   GIFtS: 44
GCID: GC12M122656

Interleukin 31

  See IL31-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 311 2
IL-312 3
interleukin-312

External Ids:    HGNC: 193721   Entrez Gene: 3866532   Ensembl: ENSG000002046717   OMIM: 6095095   UniProtKB: Q6EBC23   

Export aliases for IL31 gene to outside databases

Previous GC identifers: GC00U914001 GC12U900495 GC12M121222 GC12M119617


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL31 Gene:
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting
of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and
keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic
diseases, such as asthma (Dillon et al., 2004 (PubMed 15184896)).(supplied by OMIM, Mar 2008)

GeneCards Summary for IL31 Gene:
IL31 (interleukin 31) is a protein-coding gene. Diseases associated with IL31 include epidermolysis bullosa pruriginosa, and allergic contact dermatitis. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2
Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA
and OSMR. IL31 may function in skin immunity

Gene Wiki entry for IL31 (Interleukin 31) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL31 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   STAT5A   STAT1alpha   HFH-1   STAT3   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL31 promoter sequence
   Search Chromatin IP Primers for IL31

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

IL31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL31 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122656:  view genomic region     (about GC identifiers)

Start:
122,656,577 bp from pter      End:
122,658,746 bp from pter
Size:
2,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2 (See protein sequence)
Recommended Name: Interleukin-31 precursor  
Size: 164 amino acids; 18205 Da
Secondary accessions: A2RUQ1

Explore the universe of human proteins at neXtProt for IL31: NX_Q6EBC2

Explore proteomics data for IL31 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn67, Asn100

  • See IL31 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001014358.1  
    ENSEMBL proteins: 
     ENSP00000366234  

    IL31 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    1 InterPro protein domain:
     IPR027987 IL-31

    Graphical View of Domain Structure for InterPro Entry Q6EBC2

    ProtoNet protein and cluster: Q6EBC2


    Find genes that share domains with IL31           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL31_HUMAN, Q6EBC2
    Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA
    and OSMR. IL31 may function in skin immunity
    Induction: Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated
    circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    Find genes that share ontologies with IL31           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL31
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    SwitchGear 3'UTR luciferase reporter plasmidIL31 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL31_HUMAN, Q6EBC2: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL31           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL31: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL31

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--

    Find genes that share ontologies with IL31           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL31

    2 Novoseek inferred chemical compound relationships for IL31 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 68 3 17028186 (1), 18926762 (1), 17148439 (1)
    histamine 28.9 1 19196660 (1)



    Find genes that share compounds with IL31           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL31 gene: 
    NM_001014336.1  

    Unigene Cluster for IL31:

    Interleukin 31
    Hs.569071
    Unigene Representative Sequence: AY499343
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377035(uc001ubv.3)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate IL31:
    hsa-miR-22 hsa-miR-3121-3p hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidIL31 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat IL31

    Additional mRNA sequence: 

    AY499343.1 BC132998.1 BC133000.1 

    1 DOTS entry:

    DT.121214298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL31 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTCGCAC
    IL31 Expression
    About this image

    IL31 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL31 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.569071

    UniProtKB/Swiss-Prot: IL31_HUMAN, Q6EBC2
    Tissue specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small
    intestine and trachea

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL31: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL31

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL31 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il315 interleukin 31   --   5 (63.00 cM) 123480153 


    ENSEMBL Gene Tree for IL31 (if available)
    TreeFam Gene Tree for IL31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL31
    DNA2.0 Custom Variant and Variant Library Synthesis for IL31

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609509    OMIM disorders: --

    6 diseases for IL31:    
    About MalaCards
    epidermolysis bullosa pruriginosa    allergic contact dermatitis    contact dermatitis    primary cutaneous amyloidosis
    atopic dermatitis    asthma

    2 diseases from the University of Copenhagen DISEASES database for IL31:
    Atopic dermatitis     Primary cutaneous amyloidosis

    Find genes that share disorders with IL31           About GenesLikeMe

    9 Novoseek inferred disease relationships for IL31 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis atopic 69.2 20 15925362 (3), 16461143 (2), 16461142 (2), 18606082 (1) (see all 9)
    dermatitis 64.2 13 16461142 (4), 16461143 (2), 17030248 (1), 17627770 (1) (see all 6)
    eczema 51 8 17900679 (6), 15635736 (1), 17030248 (1)
    psoriasis 36.6 2 17030248 (1), 16461143 (1)
    skin diseases 35.2 4 17030248 (2), 16461142 (2)
    glioblastoma 31.2 1 15627637 (1)
    inflammation 6.66 4 16569341 (1), 17449633 (1), 18179886 (1), 17627770 (1)
    melanoma 5.3 1 15627637 (1)
    tumors 0 1 15627637 (1)

    Genetic Association Database (GAD): IL31
    Human Genome Epidemiology (HuGE) Navigator: IL31 (2 documents)

    Export disorders for IL31 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL31 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with IL31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PubMed id 15184896)1, 2, 3 Dillon S.R.... Gross J.A. (Nat. Immunol. 2004)
    2. Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. (PubMed id 17030248)1, 2, 9 Neis M.M....Hermanns H.M. (J. Allergy Clin. Immunol. 2006)
    3. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PubMed id 16461143)1, 2, 9 Bilsborough J.... Gross J.A. (J. Allergy Clin. Immunol. 2006)
    4. A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. (PubMed id 17900679)1, 4, 9 Schulz F....Lee Y.A. (J. Allergy Clin. Immunol. 2007)
    5. Common IL-31 gene haplotype associated with non-atopic eczema is not implicated in epidermolysis bullosa pruriginosa. (PubMed id 21057749)1, 4 Nagy N....McGrath J.A. (Acta Derm. Venereol. 2010)
    6. IL-31: a new link between T cells and pruritus in atopic skin inflammation. (PubMed id 16461142)1, 9 Sonkoly E....Homey B. (J. Allergy Clin. Immunol. 2006)
    7. Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. (PubMed id 15925362)1, 9 Takaoka A....Nakaike S. (Eur. J. Pharmacol. 2005)
    8. The histamine H4 receptor is functionally expressed on T(H)2 cells. (PubMed id 19281909)1, 9 Gutzmer R....Werfel T. (J. Allergy Clin. Immunol. 2009)
    9. Interleukin-31 stimulates production of inflammatory mediators from human colonic subepithelial myofibroblasts. (PubMed id 17487427)1, 9 Yagi Y....Fujiyama Y. (Int. J. Mol. Med. 2007)
    10. Structures and biological functions of IL-31 and IL-31 receptors. (PubMed id 18926762)1, 9 Zhang Q....Gao W. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 386653 HGNC: 19372 Ensembl:ENSG00000204671 euGenes: HUgn386653 ECgene: IL31
    H-InvDB: IL31

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL31 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL31 gene:
    Search GeneIP for patents involving IL31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL31 Predesigned siRNA for gene silencing in human, mouse, rat IL31
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     PCR Arrays including human, mouse / rat IL31 Search Chromatin IP Primers for IL31
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Search Addgene for plasmids for IL31
     eBioscience proteins for IL31 (Human IL-31 Recombinant Protein Carrier-Free 100 ug)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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