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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL3 Gene

protein-coding   GIFtS: 69
GCID: GC05P131396

Interleukin 3 (Colony-Stimulating Factor, Multiple)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 3 (Colony-Stimulating Factor, Multiple)1 2     Multipotential Colony-Stimulating Factor2 3
Hematopoietic Growth Factor1 2 3     IL-32 3
Mast-Cell Growth Factor1 2     MCGF2 3
Multilineage-Colony-Stimulating Factor1 2     P-Cell-Stimulating Factor2 3
P-Cell Stimulating Factor1 2     MULTI-CSF2
Mast Cell Growth Factor2 3     interleukin-32

External Ids:    HGNC: 60111   Entrez Gene: 35622   Ensembl: ENSG000001643997   OMIM: 1477405   UniProtKB: P087003   

Export aliases for IL3 gene to outside databases

Previous GC identifers: GC05U990034 GC05P131843 GC05P131427 GC05P131472 GC05P131424 GC05P126588


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL3 Gene:
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the
proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such
as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic
activity, and it may be associated with neurologic disorders. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL3 Gene: 
IL3 (interleukin 3 (colony-stimulating factor, multiple)) is a protein-coding gene. Diseases associated with IL3 include subcutaneous mycosis, and granulocytopenia, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include growth factor activity and interleukin-3 receptor binding.

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700
Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling
the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes
and the monocytes-macrophages
Function: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and
megakaryocytes

Gene Wiki entry for IL3 (Interleukin 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL3 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

IL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P131396:  view genomic region     (about GC identifiers)

Start:
131,396,222 bp from pter      End:
131,398,897 bp from pter
Size:
2,676 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700 (See protein sequence)
Recommended Name: Interleukin-3 precursor  
Size: 152 amino acids; 17233 Da
Subunit: Monomer
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IL3:
1JLI (3D)    
Secondary accessions: Q6GS87

Explore the universe of human proteins at neXtProt for IL3: NX_P08700

Explore proteomics data for IL3 at MOPED 

IL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL3 Protein Expression

REFSEQ proteins: NP_000579.2  
ENSEMBL proteins: 
 ENSP00000296870  
Reactome Protein details: P08700
Human Recombinant Protein Products for IL3: 
EMD Millipore Purified and/or Recombinant IL3 Protein
R&D Systems Recombinant & Natural Proteins for IL3 (IL-3)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IL3
OriGene Custom MassSpec 
OriGene Custom Protein Services for IL3
GenScript Purified and Recombinant Proteins for IL3
Novus Biologicals IL3 Proteins
Novus Biologicals IL3 Lysates
Sino Biological Recombinant Protein for IL3
Sino Biological Cell Lysate for IL3 
ProSpec Recombinant Protein for IL3
Cloud-Clone Corp. Proteins for IL3 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space ISS--

IL3 for ontologies           About GeneDecksing



IL3 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IL3 (IL-3)
Cell Signaling Technology (CST) Antibodies for IL3 
OriGene Antibodies for IL3
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GenScript Custom Superior Antibodies Services for IL3
Novus Biologicals IL3 Antibodies
Abcam antibodies for IL3
Cloud-Clone Corp. Antibodies for IL3 
ThermoFisher Antibodies for IL3
LSBio Antibodies in human, mouse, rat for IL3 

Assay Products for IL3: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL3
R&D Systems Flow Cytometry Kits for IL3 (IL-3)         (see all)
GenScript Custom Assay Services for IL3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL3 
Cloud-Clone Corp. CLIAs for IL3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

3 InterPro protein domains:
 IPR002183 Interleukin_3
 IPR012351 4_helix_cytokine_core
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P08700

ProtoNet protein and cluster: P08700

1 Blocks protein domain: IPB002183 Interleukin-3 signature

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700
Similarity: Belongs to the IL-3 family


IL3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL3_HUMAN, P08700
Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling
the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes
and the monocytes-macrophages
Function: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and
megakaryocytes

     Genatlas biochemistry entry for IL3:
interleukin 3,17.2kDa,colony-stimulating factor (multilineage),survival factor inducing phosphorylation of BAD
through the activation of the protein kinases (AKT1,AKT2)

     Summary:
During embryonic development, IL3 as signaling molecule
affects the following cells: Small Pre B-Cells in Hematopoietic Bone Marrow

IL3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Mast cell progenitor cells from , Erythroid-like cells from Blood (see all).

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005135interleukin-3 receptor binding TAS2544122
GO:0008083growth factor activity IEA--
     
IL3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IL3:
 Increased cell death in HCC-19 

     9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il3):
 cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
 mortality/aging  renal/urinary system  respiratory system  tumorigenesis 

IL3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL3: Il3tm1Glli Il3tm1Tyb

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL3 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL3
2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL3:
hsa-miR-205* hsa-miR-3121-3p
SwitchGear 3'UTR luciferase reporter plasmidIL3 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL3
Sirion Biotech Customized adenovirus for overexpression of IL3

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL3 (see all 6)
OriGene ORF clones in mouse, rat for IL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL3 (NM_000588)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3
Sirion Biotech Customized lentivirus for stable overexpression of IL3 
                     Customized lentivirus expression plasmids for stable overexpression of IL3 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL3
Search LifeMap BioReagents cell lines for IL3
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL3 About   (see all 31)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Immune response Fc epsilon RI pathway
Fc epsilon RI signaling pathway0.40
Immune response CD16 signaling in NK cells0.32
3Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
4GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
NFAT in Immune Response0.58
GPCR Pathway0.62
Estrogen Pathway0.55
Pancreatic Adenocarcinoma0.59
5TGF-Beta Pathway
TGF-Beta Pathway0.60
JNK Pathway0.51
MAPK Family Pathway0.60
Regulation of eIF4 and p70S6K0.43
JAK-STAT Pathway0.57
SOCS Pathway0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for IL3
    Immune response CD16 signaling in NK cells
Immune response IL-3 activation and signaling pathway

5/69 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL3 (see all 69)
    Telomerase Components in Cell Signaling
Molecular Mechanisms of Cancer
eIF2 Pathway
Intracellular Calcium Signaling
JNK Pathway

1 Cell Signaling Technology (CST) Pathway for IL3
    Lymphocyte Signaling

2 GeneGo (Thomson Reuters) Pathways for IL3
    Immune response IL-3 activation and signaling pathway
Immune response CD16 signaling in NK cells

5 BioSystems Pathways for IL3
    Senescence and Autophagy
IL-3 Signaling Pathway
Integrated Pancreatic Cancer Pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Calcium signaling in the CD4+ TCR pathway


5/6        Reactome Pathways for IL3 (see all 6)
    Interleukin receptor SHC signaling
Interleukin-2 signaling
Cytokine Signaling in Immune system
Interleukin-3, 5 and GM-CSF signaling
Signaling by Interleukins


5/8         Kegg Pathways  (Kegg details for IL3) (see all 8):
    Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Apoptosis
Jak-STAT signaling pathway
Hematopoietic cell lineage


IL3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/32 Interacting proteins for IL3 (P087001, 3 ENSP000002968704) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
InteractantInteraction Details
GeneCardExternal ID(s)
CSF2RBP329271, 3, ENSP000003840534EBI-1811718,EBI-1809771 I2D: score=4 STRING: ENSP00000384053
HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
PIK3CDO003293, ENSP000003665634I2D: score=1 STRING: ENSP00000366563
IL3RAP269513, ENSP000003278904I2D: score=4 STRING: ENSP00000327890
BCRP112743, ENSP000003035074I2D: score=1 STRING: ENSP00000303507
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response IEA--
GO:0007267cell-cell signaling TAS3497400
GO:0007399nervous system development TAS9736740
GO:0008284positive regulation of cell proliferation ISS--
GO:0035162embryonic hemopoiesis IDA--

IL3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL3

1 DrugBank Compound for IL3    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
AmlexanoxAmlexanox [USAN:INN:JAN] (see all 3)68302-57-8targetantagonist1378042 1701989

10/136 Novoseek inferred chemical compound relationships for IL3 gene (see all 136)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pixy321 84.7 43 1687205 (3), 1383918 (2), 7662957 (2), 7527667 (1) (see all 27)
methylcellulose 82 76 7680241 (2), 2295806 (1), 1961035 (1), 8172177 (1) (see all 53)
gm-csf 74.9 46 8431518 (2), 10613382 (2), 7683736 (2), 1333539 (2) (see all 32)
filgrastim 71.3 41 1716485 (2), 10613382 (2), 12513757 (2), 9154828 (2) (see all 26)
tyrosine 67.7 324 2166606 (5), 1400495 (5), 7636226 (5), 1692720 (4) (see all 99)
daniplestim 67 11 11480562 (5), 10512796 (2), 10781904 (1)
cytarabine 66.1 67 8689423 (3), 1760944 (3), 1893953 (2), 1556000 (2) (see all 35)
rantes 62.9 61 8998072 (5), 9116985 (2), 10998026 (2), 8757214 (2) (see all 45)
histamine 60.5 279 8874655 (9), 10233691 (9), 9676763 (9), 10963852 (6) (see all 99)
ifosfamide 59 20 1517788 (2), 1371415 (2), 8156491 (1), 8058003 (1) (see all 17)

Search CenterWatch for drugs/clinical trials and news about IL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL3 gene: 
NM_000588.3  

Unigene Cluster for IL3:

Interleukin 3 (colony-stimulating factor, multiple)
Hs.694  [show with all ESTs]
Unigene Representative Sequence: NM_000588
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000296870(uc003kwe.1)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL3
2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL3:
hsa-miR-205* hsa-miR-3121-3p
SwitchGear 3'UTR luciferase reporter plasmidIL3 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL3
Clone
Products:
     
OriGene clones in human, mouse for IL3 (see all 6)
OriGene ORF clones in mouse, rat for IL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL3 (NM_000588)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3
Sirion Biotech Customized lentivirus for stable overexpression of IL3 
                     Customized lentivirus expression plasmids for stable overexpression of IL3 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL3
OriGene qSTAR qPCR primer pairs in human, mouse for IL3
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL3

Additional mRNA sequence: 

BC066272.1 BC066273.1 BC066274.1 BC066275.1 BC066276.1 BC069472.1 M14743.1 M17115.1 
M20137.1 

1 DOTS entry:

DT.101955263 

15 AceView cDNA sequences:

BC069472 NM_000588 M17115 BC066276 BC066274 BC066272 BC066273 BC066275 
M14743 M20137 CK130265 CD559528 CD559530 CD559531 CD559529 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL3 expression in normal human tissues (normalized intensities)      IL3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCATTTGTA
IL3 Expression
About this image


IL3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/0 selected tissues (see all 0) fully expand

See IL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL3

SOURCE GeneReport for Unigene cluster: Hs.694

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700
Tissue specificity: Activated T-cells, mast cells, natural killer cells

    SABiosciences Expression via Pathway-Focused PCR Arrays including IL3 (see all 12): 
          Neurogenesis in human mouse rat
          Growth Factors in human mouse rat
          T-cell & B-cell Activation in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Th17 Response in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL3
OriGene qSTAR qPCR primer pairs in human, mouse for IL3
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL3
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL3 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il35 interleukin 3   --   11 (32.13 cM) 54265303 


ENSEMBL Gene Tree for IL3 (if available)
TreeFam Gene Tree for IL3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/161 SNPs in IL3 are shown (see all 161)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs6605971,2
C,F,A,H--131394451(-) AGCTCC/TGGTAG 1 -- us2k17Minor allele frequency- T:0.01NS EA NA WA 630
rs761671681,2
C,F--131394455(+) CGGAGC/ATAAGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
rs1825102761,2
--131394535(+) TTTGAA/TTCAGA 1 -- us2k10--------
rs20735061,2
C,F,O,H--131394738(-) ACTCCG/ATAGGC 1 -- us2k116Minor allele frequency- A:0.12NA NS EA 1786
rs20697811,2
H--131394762(+) CTAAGG/TCTCCC 1 -- us2k16Minor allele frequency- T:0.00NS EA 484
rs20697821,2
H--131394784(+) GAGTTG/ATGCCT 1 -- us2k16Minor allele frequency- A:0.00NS EA 498
rs20698041,2
C--131394836(+) GTCCAG/TGGCCC 1 -- us2k13Minor allele frequency- T:0.00NS EA 260
rs1155399161,2
C,F--131395025(+) TATCCC/TGCATC 1 -- us2k11Minor allele frequency- T:0.04WA 118
rs1177639661,2
C,F--131395037(+) CCCACA/GCTGAT 1 -- us2k11Minor allele frequency- G:0.04EA 120
rs1144831411,2
F--131395083(+) TTCCTT/AACTGC 1 -- us2k11Minor allele frequency- A:0.04WA 118

HapMap Linkage Disequilibrium report for IL3 (131396222 - 131398897 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IL3:    About this table     
Variant IDTypeSubtypePubMed ID
esv25745CNV Gain19812545


Human Gene Mutation Database (HGMD): IL3
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL3
DNA2.0 Custom Variant and Variant Library Synthesis for IL3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147740    OMIM disorders: --

20/188 diseases for IL3 (see all 188):    About MalaCards
subcutaneous mycosis    granulocytopenia    acute myeloid leukemia, adult    familial eosinophilia
cyclic thrombocytopenia    leukemoid reaction    felty's syndrome    bone marrow cancer
asthma and nasal polyps    congenital amegakaryocytic thrombocytopenia    eosinophilia    stachybotrys chartarum
idiopathic pulmonary alveolar proteinosis    atopic keratoconjunctivitis    myelodysplastic syndromes    aplastic anemia
intrinsic asthma    congenital hemolytic anemia    blood disorders    neutropenia

7 diseases from the University of Copenhagen DISEASES database for IL3:
Leukemia     Neutropenia     Anemia     Thrombocytopenia
Polycythemia     Eosinophilia     Myeloma

IL3 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/91 Novoseek inferred disease relationships for IL3 gene (see all 91)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
neutropenia 79.8 151 1693298 (5), 1384774 (3), 10634646 (2), 12917942 (2) (see all 99)
leukemia 75.7 171 1622141 (4), 11222392 (3), 7519043 (2), 10460616 (2) (see all 99)
myelodysplastic syndromes 74.9 90 7858491 (2), 15624331 (2), 2048562 (2), 9371996 (2) (see all 64)
myeloid leukemia 71.2 40 1381238 (2), 7520882 (1), 8547680 (1), 9324276 (1) (see all 31)
anemia aplastic 70.8 80 10676913 (6), 9713165 (4), 8683863 (3), 7522518 (2) (see all 43)
cytopenia 70.4 26 7576933 (3), 2018046 (1), 1949844 (1), 1520908 (1) (see all 22)
thrombocytopenia 66.5 52 8219192 (3), 9474925 (3), 9095335 (2), 10553163 (2) (see all 38)
necrosis 65.9 381 1333725 (3), 1833202 (2), 1373106 (2), 7684436 (2) (see all 99)
myeloid leukemia chronic 65.9 23 10536003 (2), 2323674 (1), 8220157 (1), 10676644 (1) (see all 17)
eosinophilia 65 40 8485042 (2), 8364199 (2), 8335853 (2), 9990366 (2) (see all 29)

Genatlas disease: IL3
leukemia,acute,lymphoblastic,preB cell,with translocation t(5;14)(q31;q32)

Genetic Association Database (GAD): IL3
Human Genome Epidemiology (HuGE) Navigator: IL3 (52 documents)
Tumor Gene Database (TGDB): IL3

Export disorders for IL3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL3 gene, integrated from 9 sources (see all 3026):
(articles sorted by number of sources associating them with IL3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. (PubMed id 3489530)1, 2, 3 Yang Y.-C....Clark S.C. (1986)
  2. Polymorphisms in eosinophil pathway genes, asthma and atopy. (PubMed id 17362254)1, 4, 9 Kabesch M....Nickel R. (2007)
  3. Interleukin 3 and schizophrenia: the impact of sex and family history. (PubMed id 17179997)1, 4, 9 Chen X....Kendler K.S. (2007)
  4. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. (PubMed id 15372320)1, 4, 9 Park B.L....Shin H.D. (2004)
  5. A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. (PubMed id 14551608)1, 4, 9 Ohashi J....Tokunaga K. (2003)
  6. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1, 4 Kenny E.E....Peter I. (2012)
  7. Confirmation of association of chromosome 5q31-33 wit h United kingdom Caucasian Graves' disease. (PubMed id 20210668)1, 4 Simmonds M.J....Gough S.C. (2010)
  8. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  9. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
  10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3562 HGNC: 6011 AceView: IL3 Ensembl:ENSG00000164399 euGenes: HUgn3562
ECgene: IL3 Kegg: 3562 H-InvDB: IL3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL3 Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPshttp://pga.gs.washington.edu/data/il3/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IL3 gene:
Search GeneIP for patents involving IL3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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