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Aliases for IL3 Gene

Aliases for IL3 Gene

  • Interleukin 3 2 3
  • Hematopoietic Growth Factor 2 3 4
  • Multipotential Colony-Stimulating Factor 3 4
  • Multilineage-Colony-Stimulating Factor 2 3
  • P-Cell Stimulating Factor 2 3
  • P-Cell-Stimulating Factor 3 4
  • Mast Cell Growth Factor 3 4
  • Mast-Cell Growth Factor 2 3
  • IL-3 3 4
  • MCGF 3 4
  • Interleukin 3 (Colony-Stimulating Factor, Multiple) 2
  • Colony-Stimulating Factor, Multiple 3
  • Colony-Stimulating Factor 2
  • MULTI-CSF 3
  • Multiple 2

External Ids for IL3 Gene

Previous GeneCards Identifiers for IL3 Gene

  • GC05U990034
  • GC05P131843
  • GC05P131427
  • GC05P131472
  • GC05P131424
  • GC05P131396
  • GC05P126588

Summaries for IL3 Gene

Entrez Gene Summary for IL3 Gene

  • The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL3 Gene

IL3 (Interleukin 3) is a Protein Coding gene. Diseases associated with IL3 include subcutaneous mycosis and stachybotrys chartarum. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include cytokine activity and interleukin-3 receptor binding.

UniProtKB/Swiss-Prot for IL3 Gene

  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages

  • This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes

Gene Wiki entry for IL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL3 Gene

Genomics for IL3 Gene

Regulatory Elements for IL3 Gene

Transcription factor binding sites by QIAGEN in the IL3 gene promoter:

Genomic Location for IL3 Gene

Chromosome:
5
Start:
132,060,529 bp from pter
End:
132,063,204 bp from pter
Size:
2,676 bases
Orientation:
Plus strand

Genomic View for IL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL3 Gene

Proteins for IL3 Gene

  • Protein details for IL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08700-IL3_HUMAN
    Recommended name:
    Interleukin-3
    Protein Accession:
    P08700
    Secondary Accessions:
    • Q6GS87

    Protein attributes for IL3 Gene

    Size:
    152 amino acids
    Molecular mass:
    17233 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for IL3 Gene

neXtProt entry for IL3 Gene

Proteomics data for IL3 Gene at MOPED

Post-translational modifications for IL3 Gene

  • Glycosylation at Asn 34 and Asn 89

Other Protein References for IL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL3 (IL3)

Protein Products

No data available for DME Specific Peptides for IL3 Gene

Domains & Families for IL3 Gene

Gene Families for IL3 Gene

Protein Domains for IL3 Gene

Graphical View of Domain Structure for InterPro Entry

P08700

UniProtKB/Swiss-Prot:

IL3_HUMAN :
  • Belongs to the IL-3 family.
Family:
  • Belongs to the IL-3 family.
genes like me logo Genes that share domains with IL3: view

Function for IL3 Gene

Molecular function for IL3 Gene

GENATLAS Biochemistry:
interleukin 3,17.2kDa,colony-stimulating factor (multilineage),survival factor inducing phosphorylation of BAD through the activation of the protein kinases (AKT1,AKT2)
UniProtKB/Swiss-Prot Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages
UniProtKB/Swiss-Prot Function:
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes

Gene Ontology (GO) - Molecular Function for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005135 interleukin-3 receptor binding TAS 2544122
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL3: view
genes like me logo Genes that share phenotypes with IL3: view

Animal Models for IL3 Gene

MGI Knock Outs for IL3:

Animal Model Products

miRNA for IL3 Gene

miRTarBase miRNAs that target IL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL3 Gene

Localization for IL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL3 Gene COMPARTMENTS Subcellular localization image for IL3 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0005622 intracellular TAS --
genes like me logo Genes that share ontologies with IL3: view

Pathways & Interactions for IL3 Gene

SuperPathways for IL3 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PEDF Induced Signaling
4 GPCR Pathway
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with IL3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Allergy & Asthma in human,mouse,rat
    • Atherosclerosis in human,mouse,rat

SIGNOR curated interactions for IL3 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0002763 positive regulation of myeloid leukocyte differentiation IBA --
GO:0006955 immune response --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IL3: view

Drugs & Compounds for IL3 Gene

(81) Drugs for IL3 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlexanox Approved, Investigational Pharma Target, antagonist Inhibitor of TBK1 and IKKeta; antiallergic agent 3
Amifostine Approved, Investigational Pharma 81
Azelastine Approved Pharma 36
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Chloramphenicol Approved Pharma 6

(56) Additional Compounds for IL3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
12-O-Tetradecanoylphorbol 13-acetate
4-Hydroperoxycyclophosphamide
5-Aza-2deoxycytidine
5fluorouracil
genes like me logo Genes that share compounds with IL3: view

Transcripts for IL3 Gene

mRNA/cDNA for IL3 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL3 Gene

Interleukin 3 (colony-stimulating factor, multiple):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL3 Gene

No ASD Table

Relevant External Links for IL3 Gene

GeneLoc Exon Structure for
IL3
ECgene alternative splicing isoforms for
IL3

Expression for IL3 Gene

mRNA expression in normal human tissues for IL3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL3 Gene



SOURCE GeneReport for Unigene cluster for IL3 Gene Hs.694

mRNA Expression by UniProt/SwissProt for IL3 Gene

P08700-IL3_HUMAN
Tissue specificity: Activated T-cells, mast cells, natural killer cells
genes like me logo Genes that share expression patterns with IL3: view

Protein tissue co-expression partners for IL3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for IL3 Gene

Orthologs for IL3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL3 35
  • 99.34 (n)
  • 98.68 (a)
IL3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il3 16
Species with no ortholog for IL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL3 Gene

ENSEMBL:
Gene Tree for IL3 (if available)
TreeFam:
Gene Tree for IL3 (if available)

Paralogs for IL3 Gene

No data available for Paralogs for IL3 Gene

Variants for IL3 Gene

Sequence variations from dbSNP and Humsavar for IL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_013071 -
VAR_013072 -
VAR_034014 -
VAR_034015 -

Structural Variations from Database of Genomic Variants (DGV) for IL3 Gene

Variant ID Type Subtype PubMed ID
esv25745 CNV Gain 19812545

Variation tolerance for IL3 Gene

Residual Variation Intolerance Score: 76.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL3 Gene

HapMap Linkage Disequilibrium report
IL3
Human Gene Mutation Database (HGMD)
IL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL3 Gene

Disorders for IL3 Gene

MalaCards: The human disease database

(45) MalaCards diseases for IL3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
subcutaneous mycosis
stachybotrys chartarum
  • stachybotrys atra
neutropenia, cyclic
  • cyclic hematopoiesis
thrombocytopenia, congenital amegakaryocytic
  • congenital amegakaryocytic thrombocytopenia
megakaryocytic leukemia
  • acute megakaryoblastic leukaemia, fab m7
- elite association
Search IL3 in MalaCards View complete list of genes associated with diseases

Genatlas disease for IL3 Gene

leukemia,acute,lymphoblastic,preB cell,with translocation t(5;14)(q31;q32)

Relevant External Links for IL3

Genetic Association Database (GAD)
IL3
Human Genome Epidemiology (HuGE) Navigator
IL3
Tumor Gene Database (TGDB):
IL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL3
genes like me logo Genes that share disorders with IL3: view

No data available for UniProtKB/Swiss-Prot for IL3 Gene

Publications for IL3 Gene

  1. Effect of NZ-107, a newly synthesized pyridazinone derivative, on antigen-induced contraction of human bronchial strips and histamine release from human lung fragments or leukocytes. (PMID: 1378042) Nagai H. … Koda A. (Int. Arch. Allergy Immunol. 1992) 23 25 26 67
  2. A phase II study of oxaliplatin, docetaxel, and GM-CSF in patients with previously treated advanced melanoma. (PMID: 19597729) Locke F. … Gajewski T.F. (Cancer Chemother. Pharmacol. 2010) 23 67
  3. A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy. (PMID: 19602112) Thunell D.H. … Guthmiller J.M. (J. Periodont. Res. 2010) 23 67
  4. Combined treatment with cytoprotective agents and radiotherapy. (PMID: 20044209) Winczura P. … Jassem J. (Cancer Treat. Rev. 2010) 23 67
  5. 1H, 13C and 15N resonance assignments of a highly-soluble murine interleukin-3 analogue with wild-type bioactivity. (PMID: 20174897) Yao S. … Norton R.S. (Biomol NMR Assign 2010) 23 67

Products for IL3 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Allergy & Asthma in human,mouse,rat
    • Atherosclerosis in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IL3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for IL3
  • Block miRNA regulation of IL3 using miScript Target Protectors

Sources for IL3 Gene

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