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IL3 Gene

protein-coding   GIFtS: 70
GCID: GC05P131396

Interleukin 3 (Colony-Stimulating Factor, Multiple)

  See IL3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 3 (Colony-Stimulating Factor, Multiple)1 2     Multipotential Colony-Stimulating Factor2 3
Hematopoietic Growth Factor1 2 3     IL-32 3
Mast-Cell Growth Factor1 2     MCGF2 3
Multilineage-Colony-Stimulating Factor1 2     P-Cell-Stimulating Factor2 3
P-Cell Stimulating Factor1 2     MULTI-CSF2
Mast Cell Growth Factor2 3     interleukin-32

External Ids:    HGNC: 60111   Entrez Gene: 35622   Ensembl: ENSG000001643997   OMIM: 1477405   UniProtKB: P087003   

Export aliases for IL3 gene to outside databases

Previous GC identifers: GC05U990034 GC05P131843 GC05P131427 GC05P131472 GC05P131424 GC05P126588


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL3 Gene:
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the
proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such
as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic
activity, and it may be associated with neurologic disorders. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL3 Gene:
IL3 (interleukin 3 (colony-stimulating factor, multiple)) is a protein-coding gene. Diseases associated with IL3 include granulocytopenia, and subcutaneous mycosis. GO annotations related to this gene include interleukin-3 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700
Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling
the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes
and the monocytes-macrophages
Function: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and
megakaryocytes

Gene Wiki entry for IL3 (Interleukin 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL3 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL3 promoter sequence
   Search Chromatin IP Primers for IL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

IL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P131396:  view genomic region     (about GC identifiers)

Start:
131,396,222 bp from pter      End:
131,398,897 bp from pter
Size:
2,676 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL3_HUMAN, P08700 (See protein sequence)
Recommended Name: Interleukin-3 precursor  
Size: 152 amino acids; 17233 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for IL3:
1JLI (3D)    
Secondary accessions: Q6GS87

Explore the universe of human proteins at neXtProt for IL3: NX_P08700

Explore proteomics data for IL3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn34, Asn89

  • See IL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000579.2  
    ENSEMBL proteins: 
     ENSP00000296870  
    Reactome Protein details: P08700

    IL3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL3 Protein
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    OriGene Protein Over-expression Lysate for IL3
    OriGene Custom MassSpec
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    GenScript Purified and Recombinant Proteins for IL3
    Novus Biologicals IL3 Proteins
    Novus Biologicals IL3 Lysates
    Sino Biological Recombinant Protein for IL3
    Sino Biological Cell Lysate for IL3
    ProSpec Recombinant Protein for IL3
    Cloud-Clone Corp. Proteins for IL3

     
    eBioscience Proteins for IL3: (see all 2
                        Human IL-3 Recombinant Protein 5 ug

     
    antibodies-online proteins for IL3 (151 products) 

     
    Search antibodies-online for peptides for IL3

    IL3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL3 (IL-3)
    Cell Signaling Technology (CST) Antibodies for IL3 
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    Novus Biologicals IL3 Antibodies
    Abcam antibodies for IL3
    Cloud-Clone Corp. Antibodies for IL3
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    antibodies-online antibodies for IL3 (164 products) 

    IL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for IL3 (IL-3)         (see all)
    GenScript Custom Assay Services for IL3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL3
    Cloud-Clone Corp. CLIAs for IL3
    Search eBioscience for ELISAs for IL3 
    antibodies-online kits for IL3 (62 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR002183 IL-3
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P08700

    ProtoNet protein and cluster: P08700

    1 Blocks protein domain: IPB002183 Interleukin-3 signature

    UniProtKB/Swiss-Prot: IL3_HUMAN, P08700
    Similarity: Belongs to the IL-3 family


    Find genes that share domains with IL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL3_HUMAN, P08700
    Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling
    the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes
    and the monocytes-macrophages
    Function: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and
    megakaryocytes

         Genatlas biochemistry entry for IL3:
    interleukin 3,17.2kDa,colony-stimulating factor (multilineage),survival factor inducing phosphorylation of BAD
    through the activation of the protein kinases (AKT1,AKT2)

         Summary: 
    During embryonic development, IL3 as signaling molecule affects the following cells:
    Blood: Small Pre B-Cells (Hematopoietic Bone Marrow)

    IL3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                fully expand
    Blood: ADAtransduced hematopoietic stem cells , Megakaryocytes-like cells      fully expand to see all 6 cells
    and also in: Mast cell progenitor cells, Enucleated erythrocytes      fully expand to see all 3 cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005135interleukin-3 receptor binding TAS2544122
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with IL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL3:
     Increased cell death in HCC-19 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il3):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with IL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL3: Il3tm1Glli Il3tm1Tyb

       genOway: Develop your customized and physiologically relevant rodent model for IL3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL3:
    hsa-mir-26b-5p (MIRT029305)

    Block miRNA regulation of human, mouse, rat IL3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IL3:
    hsa-miR-205* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL3
    Predesigned siRNA for gene silencing in human, mouse, rat IL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL3

    Clone
    Products:
         
    OriGene clones in human, mouse for IL3 (see all 5)
    OriGene ORF clones in mouse, rat for IL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL3 (NM_000588)
    Sino Biological Human cDNA Clone for IL3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL3_HUMAN, P08700: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--

    Find genes that share ontologies with IL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL3 About   (see all 31)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with IL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL3 (see all 69)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for IL3
        Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for IL3
        Immune response IL-3 activation and signaling pathway
    Immune response CD16 signaling in NK cells

    5 BioSystems Pathways for IL3
        Senescence and Autophagy
    IL-3 Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes


    2 Reactome Pathways for IL3
        Interleukin receptor SHC signaling
    Interleukin-3, 5 and GM-CSF signaling


    Selected Kegg Pathways  (Kegg details for IL3) (see all 8):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Apoptosis
    Jak-STAT signaling pathway
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL3 (see all 12): 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL3 (P087001, 3 ENSP000002968704) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSF2RBP329271, 3, ENSP000003840534EBI-1811718,EBI-1809771 I2D: score=4 STRING: ENSP00000384053
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    PIK3CDO003293, ENSP000003665634I2D: score=1 STRING: ENSP00000366563
    IL3RAP269513, ENSP000003278904I2D: score=4 STRING: ENSP00000327890
    BCRP112743, ENSP000003035074I2D: score=1 STRING: ENSP00000303507
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0007267cell-cell signaling TAS3497400
    GO:0007399nervous system development TAS9736740
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0035162embryonic hemopoiesis IDA--

    Find genes that share ontologies with IL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL3

    1 DrugBank Compound for IL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmlexanoxAmlexanox [USAN:INN:JAN] (see all 3)68302-57-8targetantagonist1378042 1701989

    Selected Novoseek inferred chemical compound relationships for IL3 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pixy321 84.7 43 1687205 (3), 1383918 (2), 7662957 (2), 7527667 (1) (see all 27)
    methylcellulose 82 76 7680241 (2), 2295806 (1), 1961035 (1), 8172177 (1) (see all 53)
    gm-csf 74.9 46 8431518 (2), 10613382 (2), 7683736 (2), 1333539 (2) (see all 32)
    filgrastim 71.3 41 1716485 (2), 10613382 (2), 12513757 (2), 9154828 (2) (see all 26)
    tyrosine 67.7 324 2166606 (5), 1400495 (5), 7636226 (5), 1692720 (4) (see all 99)
    daniplestim 67 11 11480562 (5), 10512796 (2), 10781904 (1)
    cytarabine 66.1 67 8689423 (3), 1760944 (3), 1893953 (2), 1556000 (2) (see all 35)
    rantes 62.9 61 8998072 (5), 9116985 (2), 10998026 (2), 8757214 (2) (see all 45)
    histamine 60.5 279 8874655 (9), 10233691 (9), 9676763 (9), 10963852 (6) (see all 99)
    ifosfamide 59 20 1517788 (2), 1371415 (2), 8156491 (1), 8058003 (1) (see all 17)



    Find genes that share compounds with IL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL3 gene: 
    NM_000588.3  

    Unigene Cluster for IL3:

    Interleukin 3 (colony-stimulating factor, multiple)
    Hs.694  [show with all ESTs]
    Unigene Representative Sequence: NM_000588
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296870(uc003kwe.1)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate IL3:
    hsa-miR-205* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL3 (NM_000588)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL3
      QuantiTect SYBR Green Assays in human, mouse, rat IL3
      QuantiFast Probe-based Assays in human, mouse, rat IL3

    Additional mRNA sequence: 

    BC066272.1 BC066273.1 BC066274.1 BC066275.1 BC066276.1 BC069472.1 M14743.1 M17115.1 
    M20137.1 

    1 DOTS entry:

    DT.101955263 

    15 AceView cDNA sequences:

    NM_000588 M17115 BC069472 M14743 M20137 BC066274 BC066275 BC066272 
    BC066273 BC066276 CK130265 CD559530 CD559528 CD559531 CD559529 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATTTGTA
    IL3 Expression
    About this image


    IL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.694

    UniProtKB/Swiss-Prot: IL3_HUMAN, P08700
    Tissue specificity: Activated T-cells, mast cells, natural killer cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL3 (see all 12): 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Th17 Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL3
    OriGene qSTAR qPCR primer pairs in human, mouse for IL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL3
    QuantiTect SYBR Green Assays in human, mouse, rat IL3
    QuantiFast Probe-based Assays in human, mouse, rat IL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il35 interleukin 3   --   11 (32.13 cM) 54265303 


    ENSEMBL Gene Tree for IL3 (if available)
    TreeFam Gene Tree for IL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL3 (see all 161)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
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    ----------
    rs6605971,2
    C,F,A,H--131394451(-) AGCTCC/TGGTAG 1 -- us2k17Minor allele frequency- T:0.01NS EA NA WA 630
    rs761671681,2
    C,F--131394455(+) CGGAGC/ATAAGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1825102761,2
    --131394535(+) TTTGAA/TTCAGA 1 -- us2k10--------
    rs20735061,2
    C,F,O,H--131394738(-) ACTCCG/ATAGGC 1 -- us2k116Minor allele frequency- A:0.12NA NS EA 1786
    rs20697811,2
    H--131394762(+) CTAAGG/TCTCCC 1 -- us2k16Minor allele frequency- T:0.00NS EA 484
    rs20697821,2
    H--131394784(+) GAGTTG/ATGCCT 1 -- us2k16Minor allele frequency- A:0.00NS EA 498
    rs20698041,2
    C--131394836(+) GTCCAG/TGGCCC 1 -- us2k13Minor allele frequency- T:0.00NS EA 260
    rs1155399161,2
    C,F--131395025(+) TATCCC/TGCATC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1177639661,2
    C,F--131395037(+) CCCACA/GCTGAT 1 -- us2k11Minor allele frequency- G:0.04EA 120
    rs1144831411,2
    F--131395083(+) TTCCTT/AACTGC 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for IL3 (131396222 - 131398897 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25745CNV Gain19812545

    Human Gene Mutation Database (HGMD): IL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL3
    DNA2.0 Custom Variant and Variant Library Synthesis for IL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147740    OMIM disorders: --

    Selected diseases for IL3 (see all 28):    
    About MalaCards
    granulocytopenia    subcutaneous mycosis    leukemoid reaction    cyclic thrombocytopenia
    felty's syndrome    familial eosinophilia    congenital amegakaryocytic thrombocytopenia    atopic keratoconjunctivitis
    idiopathic pulmonary alveolar proteinosis    congenital hemolytic anemia    myelodysplastic syndromes    aplastic anemia
    stachybotrys chartarum    pulmonary alveolar proteinosis    eosinophilia    keratoconjunctivitis
    wells syndrome    cellulitis    muckle-wells syndrome    neutropenia

    7 diseases from the University of Copenhagen DISEASES database for IL3:
    Leukemia     Neutropenia     Anemia     Thrombocytopenia
    Polycythemia     Eosinophilia     Myeloma

    Find genes that share disorders with IL3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL3 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neutropenia 79.8 151 1693298 (5), 1384774 (3), 10634646 (2), 12917942 (2) (see all 99)
    leukemia 75.7 171 1622141 (4), 11222392 (3), 7519043 (2), 10460616 (2) (see all 99)
    myelodysplastic syndromes 74.9 90 7858491 (2), 15624331 (2), 2048562 (2), 9371996 (2) (see all 64)
    myeloid leukemia 71.2 40 1381238 (2), 7520882 (1), 8547680 (1), 9324276 (1) (see all 31)
    anemia aplastic 70.8 80 10676913 (6), 9713165 (4), 8683863 (3), 7522518 (2) (see all 43)
    cytopenia 70.4 26 7576933 (3), 2018046 (1), 1949844 (1), 1520908 (1) (see all 22)
    thrombocytopenia 66.5 52 8219192 (3), 9474925 (3), 9095335 (2), 10553163 (2) (see all 38)
    necrosis 65.9 381 1333725 (3), 1833202 (2), 1373106 (2), 7684436 (2) (see all 99)
    myeloid leukemia chronic 65.9 23 10536003 (2), 2323674 (1), 8220157 (1), 10676644 (1) (see all 17)
    eosinophilia 65 40 8485042 (2), 8364199 (2), 8335853 (2), 9990366 (2) (see all 29)

    Genatlas disease: IL3
    leukemia,acute,lymphoblastic,preB cell,with translocation t(5;14)(q31;q32)

    Genetic Association Database (GAD): IL3
    Human Genome Epidemiology (HuGE) Navigator: IL3 (52 documents)
    Tumor Gene Database (TGDB): IL3

    Export disorders for IL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL3 gene, integrated from 10 sources (see all 3026):
    (articles sorted by number of sources associating them with IL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. (PubMed id 3489530)1, 2, 3 Yang Y.-C....Clark S.C. (Cell 1986)
    2. Polymorphisms in eosinophil pathway genes, asthma and atopy. (PubMed id 17362254)1, 4, 9 Kabesch M....Nickel R. (Allergy 2007)
    3. Interleukin 3 and schizophrenia: the impact of sex and family history. (PubMed id 17179997)1, 4, 9 Chen X....Kendler K.S. (Mol. Psychiatry 2007)
    4. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. (PubMed id 15372320)1, 4, 9 Park B.L....Shin H.D. (J. Hum. Genet. 2004)
    5. A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. (PubMed id 14551608)1, 4, 9 Ohashi J....Tokunaga K. (Genes Immun. 2003)
    6. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1, 4 Kenny E.E....Peter I. (PLoS Genet. 2012)
    7. Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease. (PubMed id 20210668)1, 4 Simmonds M.J....Gough S.C. (Thyroid 2010)
    8. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    9. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3562 HGNC: 6011 AceView: IL3 Ensembl:ENSG00000164399 euGenes: HUgn3562
    ECgene: IL3 Kegg: 3562 H-InvDB: IL3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL3 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IL3 gene:
    Search GeneIP for patents involving IL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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