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Aliases for IL3 Gene

Aliases for IL3 Gene

  • Interleukin 3 2 3 5
  • Hematopoietic Growth Factor 2 3 4
  • Multipotential Colony-Stimulating Factor 3 4
  • Multilineage-Colony-Stimulating Factor 2 3
  • Colony-Stimulating Factor, Multiple 2 3
  • P-Cell Stimulating Factor 2 3
  • Mast-Cell Growth Factor 2 3
  • IL-3 3 4
  • MCGF 3 4
  • Interleukin 3 (Colony-Stimulating Factor, Multiple) 2
  • P-Cell-Stimulating Factor 4
  • Mast Cell Growth Factor 4
  • Interleukin-3 3
  • MULTI-CSF 3

External Ids for IL3 Gene

Previous GeneCards Identifiers for IL3 Gene

  • GC05U990034
  • GC05P131843
  • GC05P131427
  • GC05P131472
  • GC05P131424
  • GC05P131396
  • GC05P126588

Summaries for IL3 Gene

Entrez Gene Summary for IL3 Gene

  • The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL3 Gene

IL3 (Interleukin 3) is a Protein Coding gene. Diseases associated with IL3 include Subcutaneous Mycosis and Neutropenia, Cyclic. Among its related pathways are Hematopoietic cell lineage and RET signaling. GO annotations related to this gene include cytokine activity and interleukin-3 receptor binding.

UniProtKB/Swiss-Prot for IL3 Gene

  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.

  • This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Gene Wiki entry for IL3 Gene

Additional gene information for IL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL3 Gene

Genomics for IL3 Gene

Regulatory Elements for IL3 Gene

Enhancers for IL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H132070 1.2 FANTOM5 ENCODE 24.8 +10.2 10242 0 ATF1 TCF12 ZNF766 GATA2 EGR1 FOS ATF7 CREM ZEB2 ELF1 CSF2 IL3 P4HA2 LOC107987500 P4HA2-AS1 PDLIM4 IL5 FNIP1 RAPGEF6 SLC22A4
GH05H132110 0.6 FANTOM5 dbSUPER 45.9 +50.6 50570 0 RUNX3 IL3 CSF2 IL5 ENSG00000253067 LOC107987500 P4HA2-AS1 RAD50 RAPGEF6 ENSG00000227616
GH05H132100 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +42.5 42460 4 PKNOX1 ATF1 ARNT ZNF766 GATA2 ELK1 FOS ATF7 RUNX3 JUNB SLC22A5 P4HA2 ENSG00000253067 CSF2 IL3 LOC107987500 P4HA2-AS1 SLC22A4 RAPGEF6 IRF1
GH05H132093 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +34.3 34343 2 HDGF TFAP4 SAP130 EBF1 ZIC2 JUND POLR2A IKZF1 EED FOS IL3 LOC107987500 P4HA2-AS1 RAPGEF6 FNIP1 SLC22A4 P4HA2 IRF1 ENSG00000253067 ENSG00000227616
GH05H132085 1.4 Ensembl ENCODE dbSUPER 12.1 +26.0 25968 1 PKNOX1 ZNF766 GATA2 ATF7 CAVIN1 ZEB2 ZNF398 ZNF518A NR2F2 ZNF592 IL3 LOC107987500 P4HA2-AS1 P4HA2 SLC22A5 ENSG00000253067 ENSG00000227616
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL3 gene promoter:

Genomic Location for IL3 Gene

Chromosome:
5
Start:
132,060,529 bp from pter
End:
132,063,204 bp from pter
Size:
2,676 bases
Orientation:
Plus strand

Genomic View for IL3 Gene

Genes around IL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL3 Gene

Proteins for IL3 Gene

  • Protein details for IL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08700-IL3_HUMAN
    Recommended name:
    Interleukin-3
    Protein Accession:
    P08700
    Secondary Accessions:
    • Q6GS87

    Protein attributes for IL3 Gene

    Size:
    152 amino acids
    Molecular mass:
    17233 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for IL3 Gene

neXtProt entry for IL3 Gene

Post-translational modifications for IL3 Gene

  • Glycosylation at isoforms=34 and isoforms=89

Other Protein References for IL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL3 (IL3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL3

Assay Products

  • Cloud-Clone Corp. Assay Kits for IL3
  • Abcam assays for IL3

No data available for DME Specific Peptides for IL3 Gene

Domains & Families for IL3 Gene

Gene Families for IL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL3 Gene

Graphical View of Domain Structure for InterPro Entry

P08700

UniProtKB/Swiss-Prot:

IL3_HUMAN :
  • Belongs to the IL-3 family.
Family:
  • Belongs to the IL-3 family.
genes like me logo Genes that share domains with IL3: view

Function for IL3 Gene

Molecular function for IL3 Gene

GENATLAS Biochemistry:
interleukin 3,17.2kDa,colony-stimulating factor (multilineage),survival factor inducing phosphorylation of BAD through the activation of the protein kinases (AKT1,AKT2)
UniProtKB/Swiss-Prot Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
UniProtKB/Swiss-Prot Function:
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Phenotypes From GWAS Catalog for IL3 Gene

Gene Ontology (GO) - Molecular Function for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005125 cytokine activity IBA --
GO:0005135 interleukin-3 receptor binding TAS 2544122
GO:0005149 interleukin-1 receptor binding IBA --
genes like me logo Genes that share ontologies with IL3: view
genes like me logo Genes that share phenotypes with IL3: view

Animal Model Products

CRISPR Products

miRNA for IL3 Gene

miRTarBase miRNAs that target IL3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL3 Gene

Localization for IL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL3 gene
Compartment Confidence
extracellular 5
mitochondrion 3
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,ISS --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with IL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL3 Gene

Pathways & Interactions for IL3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PEDF Induced Signaling
4 GPCR Pathway
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with IL3: view

SIGNOR curated interactions for IL3 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001660 fever generation IBA --
GO:0001959 regulation of cytokine-mediated signaling pathway TAS --
GO:0006955 immune response IEA --
GO:0007267 cell-cell signaling TAS 3497400
genes like me logo Genes that share ontologies with IL3: view

Drugs & Compounds for IL3 Gene

(85) Drugs for IL3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlexanox Approved, Investigational Pharma Target, antagonist Inhibitor of TBK1 and IKKeta; antiallergic agent 3
Tacrolimus Approved, Investigational Pharma 1125
Zinc Approved Pharma Target 2359

(53) Additional Compounds for IL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL3: view

Transcripts for IL3 Gene

mRNA/cDNA for IL3 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL3 Gene

Interleukin 3 (colony-stimulating factor, multiple):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IL3 Gene

No ASD Table

Relevant External Links for IL3 Gene

GeneLoc Exon Structure for
IL3
ECgene alternative splicing isoforms for
IL3

Expression for IL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL3 Gene



Protein tissue co-expression partners for IL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL3 Gene:

IL3

SOURCE GeneReport for Unigene cluster for IL3 Gene:

Hs.694

mRNA Expression by UniProt/SwissProt for IL3 Gene:

P08700-IL3_HUMAN
Tissue specificity: Activated T-cells, mast cells, natural killer cells.

Evidence on tissue expression from TISSUES for IL3 Gene

  • Blood(3.4)
  • Bone marrow(3.4)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with IL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL3 Gene

Orthologs for IL3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for IL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL3 33 34
  • 99.34 (n)
Species where no ortholog for IL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL3 Gene

ENSEMBL:
Gene Tree for IL3 (if available)
TreeFam:
Gene Tree for IL3 (if available)

Paralogs for IL3 Gene

No data available for Paralogs for IL3 Gene

Variants for IL3 Gene

Sequence variations from dbSNP and Humsavar for IL3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000713225 -- 132,063,661(+) CAGGG(C/T)CAACA downstream-variant-500B, upstream-variant-2KB
rs1000804382 -- 132,062,077(+) CTTTA(C/T)GTAGC intron-variant
rs1001370980 -- 132,059,918(+) CTGAG(C/T)TCAGC intron-variant, upstream-variant-2KB
rs1002829898 -- 132,061,101(+) CATCT(A/G)TAAAA intron-variant
rs1004216673 -- 132,063,318(+) TCTGG(A/G)TGAGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL3 Gene

Variant ID Type Subtype PubMed ID
esv25745 CNV gain 19812545
esv3606803 CNV loss 21293372
nsv1024604 CNV gain 25217958

Variation tolerance for IL3 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL3 Gene

Human Gene Mutation Database (HGMD)
IL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL3 Gene

Disorders for IL3 Gene

MalaCards: The human disease database

(54) MalaCards diseases for IL3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
subcutaneous mycosis
  • subcutaneous fungal disease
neutropenia, cyclic
  • cyclic hematopoiesis
megakaryocytic leukemia
  • acute megakaryoblastic leukaemia, fab m7
eosinophilic gastroenteritis
  • ege
eosinophilic pneumonia
  • pneumonia, eosinophilic
- elite association - COSMIC cancer census association via MalaCards
Search IL3 in MalaCards View complete list of genes associated with diseases

Genatlas disease for IL3 Gene

leukemia,acute,lymphoblastic,preB cell,with translocation t(5;14)(q31;q32)

Relevant External Links for IL3

Genetic Association Database (GAD)
IL3
Human Genome Epidemiology (HuGE) Navigator
IL3
Tumor Gene Database (TGDB):
IL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL3
genes like me logo Genes that share disorders with IL3: view

No data available for UniProtKB/Swiss-Prot for IL3 Gene

Publications for IL3 Gene

  1. Interleukin 3 and schizophrenia: the impact of sex and family history. (PMID: 17179997) Chen X … Kendler KS (Molecular psychiatry 2007) 3 22 45 60
  2. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. (PMID: 15372320) Park BL … Shin HD (Journal of human genetics 2004) 3 22 45 60
  3. Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. (PMID: 3489530) Yang YC … Wong GG (Cell 1986) 2 3 4 60
  4. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny EE … Peter I (PLoS genetics 2012) 3 45 60
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 45 60

Products for IL3 Gene

Sources for IL3 Gene

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