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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL3 Gene

protein-coding GIFtS: 69
GCID: GC05P131396

interleukin 3 (colony-stimulating factor, multiple)

Explore 204 diseases affiliated with
IL3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 3 (Colony-Stimulating Factor, Multiple)¹ ²		P-Cell-Stimulating Factor² ³
IL-3¹ ² ³		MGC79398¹
MCGF¹ ² ³		MGC79399¹
MULTI-CSF¹ ²		Interleukin-3¹
Hematopoietic Growth Factor² ³		Mast-Cell Growth Factor²
Mast Cell Growth Factor² ³		Multilineage-Colony-Stimulating Factor²
Multipotential Colony-Stimulating Factor² ³		P-Cell Stimulating Factor²

External Ids:	HGNC: 6011¹	Entrez Gene: 3562²	Ensembl: ENSG00000164399⁷	OMIM: 147740⁵	UniProtKB: P08700³

Export aliases for IL3 gene to outside databases

Previous GC identifers: GC05U990034 GC05P131843 GC05P131427 GC05P131472 GC05P131424 GC05P126588

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL3:

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the

proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as

cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it

may be associated with neurologic disorders. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700

Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the

production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the

monocytes-macrophages

Function: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and

megakaryocytes

Gene Wiki entry for IL3 (Interleukin 3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL3 gene promoter:
AML1a STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL3 promoter sequence

Search SABiosciences Chromatin IP Primers for IL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q23-q31

IL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P131396: view genomic region (about GC identifiers)

Start:	131,396,222 bp from pter	End:	131,398,897 bp from pter
Size:	2,676 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700 (See protein sequence)

Recommended Name: Interleukin-3 precursor

Size: 152 amino acids; 17233 Da

Subunit: Monomer

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for IL3:

1JLI (3D)

Secondary accessions: Q6GS87

Explore the universe of human proteins at neXtProt for IL3: NX_P08700

IL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000579.2

ENSEMBL proteins:

ENSP00000296870

Reactome Protein details: P08700
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IL3 Protein
	R&D Systems Recombinant & Natural Proteins for IL3 (IL-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IL3 OriGene Custom Protein Services for IL3
	GenScript Purified and Recombinant Proteins for IL3
	Novus Biologicals IL3 Proteins Novus Biologicals IL3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL3
	Uscn Proteins for IL3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	ISS	--

IL3 for ontologies About GeneDecksing

IL3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Cell Signaling Technology (CST) Antibodies for IL3
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	GenScript Custom Superior Antibodies Services for IL3
	Novus Biologicals IL3 Antibodies
	Abcam antibodies for IL3
	Uscn Antibodies for IL3
	ThermoFisher Antibodies for IL3

Assay Products for IL3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL3 (IL-3) (see all)
	GenScript Custom Assay Services for IL3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL3 for domains About GeneDecksing

3 InterPro domains/families:

IPR009079 4_helix_cytokine-like_core

IPR002183 Interleukin_3

IPR012351 4_helix_cytokine_core

Graphical View of Domain Structure for InterPro Entry P08700

ProtoNet protein and cluster: P08700

1 Blocks protein family: IPB002183 Interleukin-3 signature

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700

Similarity: Belongs to the IL-3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700

Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the

production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the

monocytes-macrophages

Function: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and

megakaryocytes

Genatlas biochemistry entry for IL3:

interleukin 3,17.2kDa,colony-stimulating factor (multilineage),survival factor inducing phosphorylation of BAD through

the activation of the protein kinases (AKT1,AKT2)

Summary:

During embryonic development, IL3 as signaling molecule

affects the following cells: Pre-B Cells in Peripheral Blood

IL3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Hematopoietic progenitor cells, Erythroid-like cells (see all 8).

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL3:
		hsa-miR-205* hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL3 (see all 7) OriGene shRNA RFP: IL3 OriGene siRNA: IL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL3 (NM_000588)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL3
		Search LifeMap BioReagents cell lines for IL3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005135	interleukin-3 receptor binding	TAS	2544122
GO:0008083	growth factor activity	IEA	--

IL3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL3:

Increased cell death in HCC-19

Animal Models:
Mouse knock-outs for IL3: Il3^tm1Glli Il3^tm1Mur
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il3):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	renal/urinary system	respiratory system	tumorigenesis

IL3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

Interleukin receptor SHC signaling

Interleukin receptor SHC signaling	1.00	Interleukin-3, 5 and GM-CSF signaling	0.57
Interleukin-2 signaling	0.67	The receptor is activated	0.29
Phosphorylated SHC1 recruits GRB2:GAB2	0.61	Signaling by Interleukins	0.25
SHC1 mediates cytokine-induced phosphorylation of GAB2	0.61

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IL3

	Immune response CD16 signaling in NK cells
	Immune response IL-3 activation and signaling pathway

5/69 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL3 (see all 69)

	Telomerase Components in Cell Signaling
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	JNK Pathway

1 Cell Signaling Technology (CST) Pathway for IL3

Lymphocyte Signaling

2 GeneGo (Thomson Reuters) Pathways for IL3

	Immune response IL-3 activation and signaling pathway
	Immune response CD16 signaling in NK cells

5/6 BioSystems Pathways for IL3 (see all 6)

	Senescence and Autophagy
	IL-3 Signaling Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Calcium signaling in the CD4+ TCR pathway

5/9 Reactome Pathways for IL3 (see all 9)

	SHC1 mediates cytokine-induced phosphorylation of GAB2
	Interleukin receptor SHC signaling
	Interleukin-2 signaling
	Phosphorylated SHC1 recruits GRB2:GAB2
	Cytokine Signaling in Immune system

5/6 Kegg Pathways (Kegg details for IL3) (see all 6):

	Cytokine-cytokine receptor interaction
	Apoptosis
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Fc epsilon RI signaling pathway

IL3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/32 Interacting proteins for IL3 (P08700^{1, 3} ENSP00000296870⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSF2RB	P32927¹^,³, ENSP00000384053⁴	EBI-1811718,EBI-1809771 I2D: score=4 STRING: ENSP00000384053
HRAS	P01112³, ENSP00000309845⁴	I2D: score=2 STRING: ENSP00000309845
PIK3CD	O00329³, ENSP00000366563⁴	I2D: score=1 STRING: ENSP00000366563
IL3RA	P26951³, ENSP00000327890⁴	I2D: score=4 STRING: ENSP00000327890
BCR	P11274³, ENSP00000303507⁴	I2D: score=1 STRING: ENSP00000303507

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0007267	cell-cell signaling	TAS	3497400
GO:0007399	nervous system development	TAS	9736740
GO:0008284	positive regulation of cell proliferation	ISS	--
GO:0035162	embryonic hemopoiesis	IDA	--

IL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL3

1 DrugBank Compound for IL3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Amlexanox	Amlexanox [USAN:INN:JAN] (see all 3)	68302-57-8	target	antagonist	1378042 1701989

10/136 Novoseek chemical compound relationships for IL3 gene (see all 136) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pixy321	84.7	43	1687205 (3), 1383918 (2), 7662957 (2), 7527667 (1) (see all 27)
methylcellulose	82	76	7680241 (2), 2295806 (1), 1961035 (1), 8172177 (1) (see all 53)
gm-csf	74.9	46	8431518 (2), 10613382 (2), 7683736 (2), 1333539 (2) (see all 32)
filgrastim	71.3	41	1716485 (2), 10613382 (2), 12513757 (2), 9154828 (2) (see all 26)
tyrosine	67.7	324	2166606 (5), 1400495 (5), 7636226 (5), 1692720 (4) (see all 99)
daniplestim	67	11	11480562 (5), 10512796 (2), 10781904 (1)
cytarabine	66.1	67	8689423 (3), 1760944 (3), 1893953 (2), 1556000 (2) (see all 35)
rantes	62.9	61	8998072 (5), 9116985 (2), 10998026 (2), 8757214 (2) (see all 45)
histamine	60.5	279	8874655 (9), 10233691 (9), 9676763 (9), 10963852 (6) (see all 99)
ifosfamide	59	20	1517788 (2), 1371415 (2), 8156491 (1), 8058003 (1) (see all 17)

Search CenterWatch for drugs/clinical trials and news about IL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL3 gene:

NM_000588.3

Unigene Cluster for IL3:

Interleukin 3 (colony-stimulating factor, multiple)

Hs.694 [show with all ESTs]

Unigene Representative Sequence: NM_000588

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000296870(uc003kwe.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL3:
		hsa-miR-205* hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL3 (see all 7) OriGene shRNA RFP: IL3 OriGene siRNA: IL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL3 (NM_000588)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat IL3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL3

Additional cDNA sequence:

BC066272.1 BC066273.1 BC066274.1 BC066275.1 BC066276.1 BC069472.1 M14743.1 M17115.1

M20137.1

1 DOTS entry:

DT.101955263

15 AceView cDNA sequences:

NM_000588 M17115 BC069472 BC066272 M14743 BC066275 BC066276 BC066273

M20137 BC066274 CK130265 CD559531 CD559530 CD559528 CD559529

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCATTTGTA

About this image

IL3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

See IL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL3

SOURCE GeneReport for Unigene cluster: Hs.694

UniProtKB/Swiss-Prot: IL3_HUMAN, P08700

Tissue specificity: Activated T-cells, mast cells, natural killer cells

SABiosciences Expression via Pathway-Focused PCR Arrays including IL3 (see all 12):

Neurogenesis in human mouse rat

Growth Factors in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Th17 Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat IL3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL3 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il3⁵	interleukin 3	--		11 (32.13 cM) 54265303

ENSEMBL Gene Tree for IL3 (if available)
TreeFam Gene Tree for IL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs660597^1,2	C,F,A,H,	--	131394451(-)	`AGCTCC/TGGTAG`	1	--	us2k¹		7		NS EA NA WA	630
rs76167168^1,2	C,	--	131394455(+)	`CGGAGC/ATAAGA`	1	--	us2k¹		2		NA	122
rs182510276^1,2		--	131394535(+)	`TTTGAA/TTCAGA`	1	--	us2k¹		0	--	--	--	--
rs2073506^1,2	C,F,O,H,	--	131394738(-)	`ACTCCG/ATAGGC`	1	--	us2k¹		16		NA NS EA	1786
rs2069781^1,2	H	--	131394762(+)	`CTAAGG/TCTCCC`	1	--	us2k¹		6		NS EA	484
rs2069782^1,2	H	--	131394784(+)	`GAGTTG/ATGCCT`	1	--	us2k¹		6		NS EA	498
rs2069804^1,2	C	--	131394836(+)	`GTCCAG/TGGCCC`	1	--	us2k¹		3		NS EA	260
rs115539916^1,2	F,	--	131395025(+)	`TATCCC/TGCATC`	1	--	us2k¹		1		WA	118
rs117763966^1,2	F,	--	131395037(+)	`CCCACA/GCTGAT`	1	--	us2k¹		1		EA	120
rs114483141^1,2	F,	--	131395083(+)	`TTCCTT/AACTGC`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for IL3 (131396222 - 131398897 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL3
1 CNV: 69200
Human Gene Mutation Database (HGMD): IL3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL3

DNA2.0 Custom Variant and Variant Library Synthesis for IL3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL3 for disorders           About GeneDecksing

OMIM gene information: 147740    OMIM disorders: --

20/204 diseases for IL3 (see all 204):    About MalaCards

diamond-blackfan anemia pure red-cell aplasia muckle-wells syndrome graft versus host disease

pulmonary alveolar proteinosis leukemoid reaction stachybotrys chartarum diffuse large b-cell lymphoma

congenital amegakaryocytic thrombocytopenia severe combined immunodeficiency polycythemia vera fibrous histiocytoma

subcutaneous mycosis b-cell lymphomas cyclic thrombocytopenia plasmodium falciparum malaria

malignant fibrous histiocytoma common variable immunodeficiency felty's syndrome dyskeratosis congenita

10 diseases from the University of Copenhagen DISEASES database for IL3:

Leukemia Neutropenia Eosinophilia Thrombocytopenia

Anemia Asthma Myeloma Polycythemia

Lymphoma Hypersensitivity reaction type I disease

10/91 Novoseek disease relationships for IL3 gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neutropenia	79.8	151	1693298 (5), 1384774 (3), 10634646 (2), 12917942 (2) (see all 99)
leukemia	75.7	171	1622141 (4), 11222392 (3), 7519043 (2), 10460616 (2) (see all 99)
myelodysplastic syndromes	74.9	90	7858491 (2), 15624331 (2), 2048562 (2), 9371996 (2) (see all 64)
myeloid leukemia	71.2	40	1381238 (2), 7520882 (1), 8547680 (1), 9324276 (1) (see all 31)
anemia aplastic	70.8	80	10676913 (6), 9713165 (4), 8683863 (3), 7522518 (2) (see all 43)
cytopenia	70.4	26	7576933 (3), 2018046 (1), 1949844 (1), 1520908 (1) (see all 22)
thrombocytopenia	66.5	52	8219192 (3), 9474925 (3), 9095335 (2), 10553163 (2) (see all 38)
necrosis	65.9	381	1333725 (3), 1833202 (2), 1373106 (2), 7684436 (2) (see all 99)
myeloid leukemia chronic	65.9	23	10536003 (2), 2323674 (1), 8220157 (1), 10676644 (1) (see all 17)
eosinophilia	65	40	8485042 (2), 8364199 (2), 8335853 (2), 9990366 (2) (see all 29)

Genatlas disease: IL3

leukemia,acute,lymphoblastic,preB cell,with translocation t(5;14)(q31;q32)

Genetic Association Database (GAD): IL3
Human Genome Epidemiology (HuGE) Navigator: IL3 (52 documents)
Tumor Gene Database (TGDB): IL3

Export disorders for IL3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL3 gene, integrated from 9 sources (see all 3021):
(articles sorted by number of sources associating them with IL3)

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world of online information

Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. (PubMed id 3489530)^{1, 2, 3} Yang Y.-C....Clark S.C. (1986)
Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. (PubMed id 15372320)^{1, 4, 9} Park B.L....Shin H.D. (2004)
A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. (PubMed id 14551608)^{1, 4, 9} Ohashi J....Tokunaga K. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{1, 2} Schmutz J.... Rubin E.M. (2004)
Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease. (PubMed id 11179015)^{1, 4} Yamada R....Yamamoto K. (2001)
Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. (PubMed id 8676386)^{1, 2} Feng Y.... McWherter C.A. (1996)
Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3. (PubMed id 2544122)^{1, 2} Urdal D.L....Park L.S. (1989)
Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones. (PubMed id 3127463)^{1, 2} Otsuka T.... Yokota T. (1988)
Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3. (PubMed id 3497843)^{1, 2} Dorssers L.... Wagemaker G. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3562	HGNC: 6011	AceView: IL3	Ensembl:ENSG00000164399	euGenes: HUgn3562
ECgene: IL3	Kegg: 3562	H-InvDB: IL3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL3	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/il3/

Intellectual Property for IL3 gene
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Patent Information for IL3 gene:
Search GeneIP for patents involving IL3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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IL3 Gene

interleukin 3 (colony-stimulating factor, multiple)

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AMEGAKARYOCYTIC THROMBOCYTOPENIA, CONGENITAL
Hematologic Effects
Polycythemia
Radiation Syndrome
Leukemoid Reaction
Leukemia T-Cell
Erythroleukemia
GRANULOCYTOPENIA SEVERE
Allergic Reaction
Megakaryoblastic Leukemia Acute
Aplasia
Keratoconjunctivitis Vernal
allergy
NSCLC
Asthma
Cancer
Thrombocytopenia
Lymphoma
Ovarian Cancer
Myeloproliferative Disorders
Pneumonia Eosinophilic
Nasal Polyps
NEUTROPENIA, SEVERE CONGENITAL
MARROW HYPERCELLULAR
Inflammation
Anemia Hypoplastic Congenital
HEMATOLOGIC DISORDERS
evaluable disease
Leukemia Hairy Cell
Neutropenia
Anemia
MYELOMA
Idiopathic Hypereosinophilic Syndrome
Tumors
DIAMOND-BLACKFAN ANEMIA
DEPRESSION BONE MARROW
Lymphoblastic Leukemia Acute
Necrosis
Asthma allergic
Anemia Refractory
breast cancer metastatic
Pulmonary Alveolar Proteinosis
Thrombocytosis
Leukemia Nonlymphocytic Acute
Myeloid Leukemia
promyelocytic leukemia
CML chronic phase
Leukocytosis
Bacterial Infections
Hodgkin Disease
B-ALL
Minimal Residual Disease
ACUTE LEUKEMIA
Myeloid Leukemia Chronic
Leukemia
Leukopenia
abnormal secretion
Severe Combined Immunodeficiency
Pancytopenia
Blast Crisis
Hematopoietic Malignancies
Agranulocytosis
Fanconis Anemia
Hematologic Malignancies
small cell lung cancer
NEUTROPENIA CYCLIC
Mastocytoma
Polycythemia Vera
Basophilia
cytopenia
Diphtheria
T-ALL
Eosinophilia
mucositis
Erythrocytosis
solid tumor
idiopathic myelofibrosis
Leukemia Promyelocytic Acute
primary myelofibrosis
Kostmanns syndrome
secondary AML
Chromosomal Aberrations
Anemia Aplastic
Graft-Versus-Host Disease
Thrombocythemia Essential
Lymphoma Non-Hodgkins
leukemogenesis
Neutropenia drug-induced
Feltys Syndrome
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC

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IL3 Gene

interleukin 3 (colony-stimulating factor, multiple)

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