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IL2RB Gene

protein-coding   GIFtS: 68
GCID: GC22M037515

Interleukin 2 Receptor, Beta

(Previous names: interleukin 15 receptor, beta)
(Previous symbol: IL15RB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 2 Receptor, Beta1 2     IL-2R Subunit Beta2 3
IL15RB1 2     p752 3
Interleukin 15 Receptor, Beta1 2     CD1222
High Affinity IL-2 Receptor Subunit Beta2 3     P70-752
IL-2RB2 3     High Affinity IL-2 Receptor Beta Subunit2
CD122 Antigen2 3     Interleukin-2 Receptor Subunit Beta2
IL-2 Receptor Subunit Beta2 3     p70-753

External Ids:    HGNC: 60091   Entrez Gene: 35602   Ensembl: ENSG000001003857   OMIM: 1467105   UniProtKB: P147843   
ORGUL members:         

Export aliases for IL2RB gene to outside databases

Previous GC identifers: GC22M034136 GC22M035764 GC22M035846 GC22M020487


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL2RB Gene:
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with
respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not
involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer,
while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high
affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic
signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane
protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL2RB Gene:
IL2RB (interleukin 2 receptor, beta) is a protein-coding gene. Diseases associated with IL2RB include orchitis, and occipital neuralgia. GO annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding.

UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784
Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and
transduces the mitogenic signals of IL2

Gene Wiki entry for IL2RB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL2RB gene promoter:
         Elk-1   GATA-3   STAT5A   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL2RB promoter sequence
   Search Chromatin IP Primers for IL2RB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL2RB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13

IL2RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL2RB gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037515:  view genomic region     (about GC identifiers)

Start:
37,521,878 bp from pter      End:
37,571,094 bp from pter
Size:
49,217 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784 (See protein sequence)
Recommended Name: Interleukin-2 receptor subunit beta precursor  
Size: 551 amino acids; 61117 Da
Subunit: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity
dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and
intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.
Interacts with HTLV-1 accessory protein p12I
6 PDB 3D structures from and Proteopedia for IL2RB:
1ILM (3D)        1ILN (3D)        2B5I (3D)        2ERJ (3D)        3QAZ (3D)        4GS7 (3D)    
Secondary accessions: B2R765

Explore the universe of human proteins at neXtProt for IL2RB: NX_P14784

Explore proteomics data for IL2RB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29, Asn43, Asn71, Asn149
  • Modification sites at PhosphoSitePlus

  • See IL2RB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000869.1  
    ENSEMBL proteins: 
     ENSP00000216223   ENSP00000403731   ENSP00000402685   ENSP00000400416   ENSP00000401020  
    Reactome Protein details: P14784

    IL2RB Human Recombinant Protein Products:

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    Novus Biologicals IL2RB Lysates
    Sino Biological Recombinant Protein for IL2RB
    Sino Biological Cell Lysate for IL2RB
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    Browse Proteins at Cloud-Clone Corp.

    IL2RB Antibody Products:

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    Novus Biologicals IL2RB Antibodies
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    IL2RB Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-2 receptor beta subunit
    IL-2 receptor family

    3 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003531 Hempt_rcpt_S_F1_CS

    Graphical View of Domain Structure for InterPro Entry P14784

    ProtoNet protein and cluster: P14784

    1 Blocks protein domain: IPB003531 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily
    Similarity: Contains 1 fibronectin type-III domain


    IL2RB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL2RB_HUMAN, P14784
    Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and
    transduces the mitogenic signals of IL2

         Genatlas biochemistry entry for IL2RB:
    interleukin 2,high affinity receptor,beta chain 70-75kDa,hematopoietic receptor family,expressed in various
    tissues

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004911contributes to interleukin-2 receptor activity TAS2467293
    GO:0005515protein binding ----
    GO:0019976interleukin-2 binding ISS--
         
    IL2RB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL2RB:
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il2rb):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     immune system  integument  liver/biliary system  mortality/aging  reproductive system 

    IL2RB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il2rbtm1Mak for IL2RB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL2RB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL2RB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL2RB

    miRNA
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    Block miRNA regulation of human, mouse, rat IL2RB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL2RB (see all 11):
    hsa-miR-146b-3p hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-24 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidIL2RB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat IL2RB

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for IL2RB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL2RB (NM_000878)
    Sino Biological Human cDNA Clone for IL2RB
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL2RB_HUMAN, P14784: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8514792
    GO:0009897external side of plasma membrane ISS--

    IL2RB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL2RB About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    NFAT Signaling and Lymphocyte Interactions0.57
    Glucocorticoid Receptor Signaling0.43
    PGC1Alpha Pathway0.51
    Cytokine-cytokine receptor interaction0.43
    STAT3 Pathway0.47
    2IL2-mediated signaling events
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    4Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for IL2RB
        IL-2 Signaling Pathways
    IL-15 Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL2RB (see all 15)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    ICos-ICosL Pathway in T-Helper Cell

    2 Cell Signaling Technology (CST) Pathways for IL2RB
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for IL2RB
        Immune response IL-22 signaling pathway
    Immune response IL-2 activation and signaling pathway

    Selected BioSystems Pathways for IL2RB (see all 8)
        IL-5 Signaling Pathway
    IL-2 Signaling pathway
    IL2 signaling events mediated by PI3K
    IL2-mediated signaling events
    IL12-mediated signaling events


    2 Reactome Pathways for IL2RB
        Interleukin receptor SHC signaling
    Interleukin-2 signaling


    Selected Kegg Pathways  (Kegg details for IL2RB) (see all 7):
        Cytokine-cytokine receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Measles


    IL2RB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2RB: 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL2RB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL2RB (P147842, 3 ENSP000002162234) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT5AP422292, 3, ENSP000003412084MINT-8035160 I2D: score=4 STRING: ENSP00000341208
    STAT5BP516922, 3, ENSP000002933284MINT-8035171 I2D: score=4 STRING: ENSP00000293328
    SHBQ154642, 3, ENSP000003669364MINT-8035186 I2D: score=3 STRING: ENSP00000366936
    GNB2L1P632443, ENSP000003660134I2D: score=4 STRING: ENSP00000366013
    SHC1P293533, ENSP000004013034I2D: score=4 STRING: ENSP00000401303
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS2467293
    GO:0007165signal transduction TAS2785715
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0019221cytokine-mediated signaling pathway IDA7736574

    IL2RB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL2RB

    4 DrugBank Compounds for IL2RB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AldesleukinIL-2 (see all 4)85898-30-2targetagonist modulator16542139 16617454 16569767 11752352 16477002 16596189
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3targetantibody11840795 11752352 12826150 10188761 12667677 10708100
    DaclizumabAnti-IL-2 (see all 3)152923-56-3targetantibody15022409 2571203 11752352 2647626 12372041 15814281
    Denileukin diftitoxDiphtheria toxin precursor (see all 3)173146-27-5targetagonist16516670 15811959 11752352 17187516 18684057

    Selected Novoseek inferred chemical compound relationships for IL2RB gene (see all 118)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    daclizumab 75.5 25 11359452 (2), 20415630 (2), 9794841 (1), 11004222 (1) (see all 21)
    neopterin 74.5 56 9892527 (5), 7647844 (3), 17975200 (2), 1606739 (2) (see all 41)
    okt3 66.8 13 2148645 (2), 2121373 (2), 1916932 (1), 8027539 (1) (see all 9)
    denileukin diftitox 65.3 12 15353540 (1), 19707452 (1), 16410787 (1), 18295790 (1) (see all 6)
    basiliximab 62.4 14 12667677 (2), 11840795 (2), 10188761 (1), 17150025 (1) (see all 10)
    cyclosporin a 58.7 30 1864010 (2), 1864013 (1), 1346344 (1), 7509146 (1) (see all 26)
    r-il-2 53.8 1 7576120 (1)
    thymoglobulin 53.4 7 15041353 (1), 15575919 (1), 17927304 (1), 19236436 (1) (see all 7)
    ionomycin 50.8 5 8344700 (1), 1654606 (1), 2017664 (1), 11347470 (1) (see all 5)
    tyrosine 50.4 68 1639773 (3), 8089104 (3), 2007186 (3), 7612266 (2) (see all 50)



    IL2RB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL2RB gene: 
    NM_000878.3  

    Unigene Cluster for IL2RB:

    Interleukin 2 receptor, beta
    Hs.474787  [show with all ESTs]
    Unigene Representative Sequence: NM_000878
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216223(uc003aqv.1) ENST00000483573 ENST00000453962 ENST00000429622
    ENST00000461607 ENST00000440958 ENST00000445595
    miRNA
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    hsa-miR-146b-3p hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-24 hsa-miR-195 hsa-miR-16 hsa-miR-15b
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat IL2RB
      QuantiFast Probe-based Assays in human, mouse, rat IL2RB

    Additional mRNA sequence: 

    AK312860.1 BC025691.1 CR456506.1 M26062.1 

    7 DOTS entries:

    DT.312677  DT.120651820  DT.120651728  DT.120651741  DT.91695341  DT.65286096  DT.91692959 

    Selected AceView cDNA sequences (see all 209):

    BX378224 H55712 BQ707555 NM_182486 BQ053622 AL708630 CR606760 BC025691 
    AI968918 BQ008149 BQ053441 CR456506 AK128125 BF223041 T28565 H55257 
    BM722009 BX339049 CD633231 AI989994 H55722 M26062 BU859813 NM_000878 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL2RB    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                          -                       -                                             
    SP2:                          -           -     -     -     -                                       
    SP3:                          -                                                                     
    SP4:                                                                                                


    ECgene alternative splicing isoforms for IL2RB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL2RB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTCCTG
    IL2RB Expression
    About this image


    IL2RB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Natural Killer Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    IL2RB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL2RB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474787
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2RB: 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL2RB
    OriGene qSTAR qPCR primer pairs in human, mouse for IL2RB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL2RB
    QuantiTect SYBR Green Assays in human, mouse, rat IL2RB
    QuantiFast Probe-based Assays in human, mouse, rat IL2RB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL2RB gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il2rb1 , 5 interleukin 2 receptor, beta chain1, 5 71.04(n)1
    59.36(a)1
      15 (37.52 cM)5
    161851  NM_008368.41  NP_032394.11 
     784805535 
    chicken
    (Gallus gallus)
    Aves IL2RB6
    interleukin 2 receptor, beta
    31(a)
    1 ↔ 1
    1(51302272-51314508)
    lizard
    (Anolis carolinensis)
    Reptilia IL2RB6
    interleukin 2 receptor, beta
    25(a)
    1 ↔ 1
    5(22752570-22783364)
    zebrafish
    (Danio rerio)
    Actinopterygii il2rb6
    interleukin 2 receptor, beta
    21(a)
    1 ↔ 1
    3(25292633-25310273) ENSDARG00000075720


    ENSEMBL Gene Tree for IL2RB (if available)
    TreeFam Gene Tree for IL2RB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for IL2RB gene

    IL2RB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IL2RB
    PGOHUM00000250326


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL2RB (see all 720)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32183361,2
    C,F,H--37521478(-) CCAGAC/TCAGGG 1 -- ds50016Minor allele frequency- T:0.01NS EA 504
    rs1451375261,2
    --37521544(+) GGGGG-/ATAGAG 1 -- ds50010--------
    rs588099631,2
    C--37521546(+) TAGAG-/A/GAG 
     
    /GAGAGG
    GGGGG
    3 -- ds5001 cds10--------
    rs2015612361,2
    --37521548(+) GATAG-/AGGGGG 1 -- ds50010--------
    rs1468544241,2
    C--37521646(+) TATTT-/CCCCAG 1 -- ds50010--------
    rs32183351,2
    C,F--37521662(-) TCCCAC/TAAGTC 1 -- ds50012Minor allele frequency- T:0.01NS 82
    rs1862350861,2
    --37521670(+) GGATAA/TGGCCA 1 -- ds50010--------
    rs1889496841,2
    --37521802(+) GTCTTC/TGACAG 1 -- ds50010--------
    rs1813940081,2
    --37521838(+) TTTAAG/TAGACA 1 -- ds50010--------
    rs1858205031,2
    C--37521859(+) CGCAGA/GCAATG 1 -- ds50010--------
    rs1910612601,2
    --37521925(+) ATAGCA/GAAAAT 1 -- ut310--------
    rs32183341,2
    C,F,H--37521933(-) AAAAAC/ACCATT 1 -- ut313Minor allele frequency- A:0.02NS WA 96
    rs1831589571,2
    --37521980(+) ATGTAC/TTTCAA 1 -- ut310--------
    rs32183331,2
    C,F,H--37521997(-) AAGTCA/GGTTCA 1 -- ut3116Minor allele frequency- G:0.04NS EA NA MN WA 1694
    rs156961,2
    C,H--37522056(+) ATTAAA/GAGATA 1 -- ut3110Minor allele frequency- G:0.00MN NS EA 998
    rs1862136781,2
    --37522112(+) TGTAAA/CCCTCC 1 -- ut310--------
    rs1391744461,2
    C--37522273(+) TATGGC/TAGGAG 1 -- ut310--------
    rs1906796921,2
    --37522277(+) GCAGGA/CGGTGA 1 -- ut310--------
    rs32183671,2
    C,F,H--37522291(-) ATTATT/AGGACA 1 -- ut31 ese37Minor allele frequency- A:0.02NS NA 354
    rs1464132401,2
    C--37522326(+) CAAGAC/TTCAGA 1 -- ut310--------
    rs1832950721,2
    --37522400(+) AGCAGA/CCCTCT 1 -- ut310--------
    rs3739880541,2
    C--37522437(+) ACCCAA/GGTCCT 1 -- ut310--------
    rs1396284941,2
    --37522648(+) GCCTGG/TGGGGG 1 -- ut310--------
    rs1497336951,2
    C--37522690(+) AAGGCC/TTGTAA 1 -- ut310--------
    rs1148452161,2
    C--37522707(+) GTGCCC/TGAGGG 1 -- ut310--------
    rs2289381,2
    C,F,A,H--37522765(-) ACAACA/CTTCCA 1 -- ut3113Minor allele frequency- C:0.20NS MN EA NA WA 1476
    rs1456218531,2
    C--37522807(+) AGATAC/GGTGGA 1 -- ut310--------
    rs2289391,2
    C,F,A,H--37523028(-) TCCAGA/GAGGGC 1 -- ut31 ese314Minor allele frequency- G:0.18MN NS EA NA WA CSA 1483
    rs1488875611,2
    --37523105(+) AGGCCC/TGGCAG 1 -- ut310--------
    rs558746491,2
    --37523246(+) ATCTGC/TGCCCT 1 -- ut310--------
    rs1406476131,2
    C--37523247(+) CTGTG-/CCCCCTT 1 -- ut310--------
    rs413098021,2
    C,F--37523272(+) ATTAAA/GGATAC 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs32183661,2
    C,F--37523306(-) TGGGAT/ACTCTG 1 -- ut31 ese33Minor allele frequency- A:0.01NS NA 86
    rs2289401,2
    C,F--37523320(-) TGTTAC/TTATTC 1 -- ut31 ese32Minor allele frequency- T:0.04MN WA 302
    rs32183321,2
    C,F--37523431(-) TTTGCT/GTCTCC 1 -- ut31 ese32Minor allele frequency- G:0.01NS 92
    rs413098041,2
    C,F--37523485(+) GGGAGC/GGCACA 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs32183651,2
    C--37523490(-) GCTGCT/AGTGCG 1 -- ut31 ese33Minor allele frequency- A:0.01NS NA 84
    rs32183311,2
    C--37523601(-) TGTACC/TTCCGG 1 -- ut31 ese32Minor allele frequency- T:0.01NS 88
    rs1926270991,2
    --37523624(+) AGAAGC/TGGGGC 1 -- ut310--------
    rs1854179881,2
    --37523636(+) GAGGGC/TAGTGG 1 -- ut310--------
    rs32183301,2
    C,F,H--37523664(-) CCCCTA/C/TGGTTC 2 -- ut31 ese34NS 496
    rs32183291,2
    C,F,H--37523692(-) TTTCCA/CAAACC 1 -- ut31 ese312Minor allele frequency- C:0.22NS EA WA CSA 1300
    rs2289411,2
    C,F,A,H--37523721(-) TCCCCG/CTCCAC 1 -- ut31 ese322Minor allele frequency- C:0.40NA EA NS MN WA CSA 2966
    rs1895368751,2
    --37523764(+) CCAGGG/TAAGAG 1 -- ut310--------
    rs767943341,2
    C,F--37523836(+) GAGAGG/CAGCGA 1 -- ut311Minor allele frequency- C:0.02EA 120
    rs1921464861,2
    --37523861(+) AATTCA/GTGGGA 1 -- ut310--------
    rs1849189971,2
    --37523993(+) AGGACG/TGGGTG 1 -- ut310--------
    rs32183281,2
    C,F,A,H--37524008(-) CACCCG/AGATGG 1 -- ut31 ese36Minor allele frequency- A:0.01NS NA 650
    rs32183271,2
    C,F,H--37524044(-) GAGGAC/TACTCA 1 -- ut31 ese317Minor allele frequency- T:0.10NS EA NA WA 1924
    rs32183261,2
    C,F,H--37524092(-) TGCGCC/TGAGCC 1 -- ut31 ese311Minor allele frequency- T:0.03NS NA WA 1360
    rs1470383911,2
    C,F--37524140(+) TCTACA/GCCAAG 2 A V mis11Minor allele frequency- G:0.00NA 4222
    rs2008313711,2
    C--37524245(+) CAGGAA/GGCCTG 2 P L mis10--------
    rs2001683331,2
    C--37524286(+) CCAGCA/GTCAGG 2 D syn10--------
    rs2021990751,2
    --37524364(+) CCTGGC/GGTGGG 2 T syn10--------
    rs2014285241,2
    --37524365(+) CTGGGA/GTGGGA 2 T I mis10--------
    rs1886959481,2
    --37524379(+) CCCAGA/GGGCTG 2 P syn10--------
    rs2003392341,2
    C--37524387(+) CTGGGA/GGTCCC 2 P S mis10--------
    rs351345621,2
    C--37524388(+) TGGGGG/ATCCCA 2 /D syn12Minor allele frequency- A:0.06WA 120
    rs1995814761,2
    --37524433(+) ATCCTA/CTCTTC 2 E D mis10--------
    rs1811776391,2
    C--37524483(+) GGGGCC/TACCGA 2 S G mis10--------
    rs1437044701,2
    C--37524496(+) AGACTA/G/TGGGGA 3 P syn11NA 2914
    rs1859691641,2
    C--37524544(+) TAGGCA/GTCGTC 2 D syn10--------
    rs1510482011,2
    F--37524547(+) GCGTCG/ATCCTC 2 /D syn11Minor allele frequency- A:0.00NA 4180
    rs2006639951,2
    --37524559(+) CCTGAC/GAGAGG 2 L syn10--------
    rs1888699231,2
    C--37524600(+) TGCCCC/TGGCCA 2 R G mis10--------
    rs2289421,2,,4
    C,F,A,H--37524619(-) GAAGAC/ACCTGA 2 /E /D mis1 ese334Minor allele frequency- A:0.17EA NS MN NA WA CSA EU 10285
    rs1824829131,2
    C--37524639(+) GGGGTC/TGTAAG 2 N D mis10--------
    rs1469867311,2
    C,F--37524640(+) GGGTCG/ATAAGT 2 /Y syn11Minor allele frequency- A:0.00NA 4546
    rs1494970901,2
    C,F--37524662(+) GGCAGG/CCCTCT 2 /A /G mis12Minor allele frequency- C:0.00NA EU 5791
    rs1480744271,2
    C--37524683(+) CATCCA/GGGAGG 2 P L mis10--------
    rs1411598741,2
    C,F--37524774(+) GTCCTG/TCTGCA 2 K Q mis11Minor allele frequency- T:0.00NA 4516
    rs1438575821,2
    C,F--37524843(+) CAGGCC/TGCCAG 2 S G mis12Minor allele frequency- T:0.00NA EU 4853
    rs1418382041,2
    C--37524928(+) GGCTTC/TCTTCA 1 -- int10--------
    rs2289431,2
    C--37524981(-) CAGGAG/CGAGGA 1 -- int1 trp32Minor allele frequency- C:0.00MN NA 186
    rs800517111,2
    C,F--37524990(+) TGAAGC/TAGTTG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs775400481,2
    C--37525044(+) CCGCAC/TTCCCC 1 -- int10--------
    rs1869984111,2
    --37525140(+) TGCCAA/GTAGTG 1 -- int10--------
    rs764848201,2
    F--37525200(+) ATGAGC/TCTGGC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs844581,2
    C,F,A,H--37525208(+) GGCACT/CGTTCT 1 -- int134Minor allele frequency- C:0.29NS EA NA WA CSA 3661
    rs844591,2
    C,F,A,H--37525320(+) GAGAGT/CACAGC 1 -- int123Minor allele frequency- C:0.36NA EA NS WA CSA 2776
    rs734069421,2
    C,F--37525351(+) CAGAGA/TCGGGA 1 -- int12Minor allele frequency- T:0.05WA 120
    rs2289441,2
    C,F,A,H--37525370(-) TGATCA/GGGGCC 1 -- int113Minor allele frequency- G:0.37EA NS NA WA CSA 1946
    rs1910783681,2
    --37525434(+) GGAACA/GTCTCT 1 -- int10--------
    rs32183251,2
    C,F--37525509(-) GGAGGC/TGGAGG 1 -- int12Minor allele frequency- T:0.04NS 84
    rs1457828401,2
    C--37525595(+) GGGAA-/GGACCC 1 -- int10--------
    rs1853029741,2
    --37525658(+) CCTGCA/GCCTCT 1 -- int10--------
    rs844601,2
    C,F,A,H--37525731(-) TCTCCT/CTGGTG 1 -- int134Minor allele frequency- C:0.35NA EA NS WA CSA 4615
    rs1168775501,2
    F--37525766(+) AAACAC/ACCAAA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1903569991,2
    --37525773(+) CAAAAC/TGGGTA 1 -- int10--------
    rs2289451,2
    C,F,A,H--37525880(-) TTCCCA/GGGACA 1 -- int120Minor allele frequency- G:0.39EA NS MN NA WA CSA 2545
    rs622308291,2
    C,F--37525933(+) GCCCAA/GTGGGC 1 -- int13Minor allele frequency- G:0.08NA 124
    rs1826241531,2
    --37526012(+) ACAAAA/TGCCCA 1 -- int10--------
    rs1482280851,2
    C--37526066(+) CGCAG-/ACACACA 1 -- int10--------
    rs1421730121,2
    --37526156(+) AGGAGG/TTATGT 1 -- int10--------
    rs1463544631,2
    C--37526206(+) GAGGAC/TGGCAA 1 -- int10--------
    rs1392172321,2
    C--37526244(+) AGAAGC/TACTGG 1 -- int10--------
    rs32183641,2
    C,F--37526347(-) CTCACC/TGGCAC 1 -- int14Minor allele frequency- T:0.02NS NA 208
    rs2289461,2
    C,F,A,H--37526359(-) GTGGGC/TCCCTG 1 -- int115Minor allele frequency- T:0.30NS MN NA WA CSA EA 640
    rs1875764631,2
    --37526465(+) CACTCA/GCACAC 1 -- int10--------
    rs1905237581,2
    --37526499(+) TGGGGA/GTGGGC 1 -- int10--------
    rs2289471,2
    C,F,A,H--37526529(-) CTCCAC/TCCTAG 1 -- int130Minor allele frequency- A:0.00EA NA NS MN WA CSA 3392
    rs1840580731,2
    --37526625(+) GACCCC/TGCTCC 1 -- int10--------
    rs1886143311,2
    --37526696(+) CCTCAC/TGATGT 1 -- int10--------
    rs1424155701,2
    --37526739(+) AAGGTA/TTCTGA 1 -- int10--------
    rs1438759881,2
    --37526900(+) TTCCCA/GCACAT 1 -- int10--------
    rs1486247911,2
    --37526940(+) GGTGGA/CGCACG 1 -- int10--------
    rs1420563221,2
    --37526954(+) GTAATC/TCCAGC 1 -- int10--------
    rs32183241,2
    C,F--37526963(-) TCCCAA/GAGTGC 1 -- int12Minor allele frequency- G:0.01NS 84
    rs1932437401,2
    --37527033(+) AAAACC/TCCGTC 1 -- int10--------
    rs1845274841,2
    --37527036(+) ACCCCA/GTCTCT 1 -- int10--------
    rs1433908351,2
    C--37527210(+) TCAAA-/AAAT  
            
    AAATA
    1 -- int10--------
    rs576368391,2
    C--37527233(+) ATAAA-/TAAA  
            
    AGCAC
    1 -- int11Minor allele frequency- TAAA:0.00NA 2
    rs1175937041,2
    C,F--37527270(+) GGGAGT/CTTTCC 1 -- int11Minor allele frequency- C:0.03EA 120
    rs2008058501,2
    C--37527365(+) CCTCCC/TCCGCC 1 -- int10--------
    rs1469315021,2
    C--37527408(+) TCCCC-/ACCCCC 1 -- int10--------
    rs117031171,2
    H--37527548(+) GTTTAC/GAGCGT 1 -- int10--------
    rs1865715791,2
    C--37527552(+) AGAGCA/GTTACT 1 -- int10--------
    rs1918183411,2
    --37527564(+) ATCTGC/TGGGCC 1 -- int10--------
    rs1838512001,2
    --37527571(+) GGCCGA/GCACTT 1 -- int10--------
    rs1889558961,2
    --37527612(+) GTGACA/GGGAAG 1 -- int10--------
    rs1815082961,2
    --37527773(+) CAGATA/TGGGTA 1 -- int10--------
    rs606469541,2
    C,F--37527809(+) TCTCAC/TTCTGT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1852583141,2
    --37527816(+) CTGTCA/GCCCAG 1 -- int10--------
    rs1452503771,2
    C--37527818(+) GTCGCC/TCAGGC 1 -- int10--------
    rs1476037621,2
    C--37527872(+) CCTGGA/GTTCAA 1 -- int10--------
    rs108546971,2
    C,A,H--37527884(+) CGATTG/CCCCTG 1 -- int12Minor allele frequency- C:0.00NA 4
    rs2289481,2
    C,A,H--37527926(-) GGTGGC/TGCATG 1 -- int13Minor allele frequency- T:0.17NA 6
    rs1452414421,2
    --37527960(+) TAGTAC/GAGACA 1 -- int10--------
    rs1905749521,2
    --37527998(+) CTCGAA/TCTCCT 1 -- int10--------
    rs2289491,2
    C,F,A--37528016(-) CAGGTA/GGATCA 1 -- int17Minor allele frequency- G:0.32NS NA CSA 102
    rs2289501,2
    C,F,A--37528026(-) GAGGCT/CGTGGC 1 -- int18Minor allele frequency- C:0.35NS NA CSA 106
    rs32183231,2
    C,F--37528040(-) TCCCAG/CCACTT 1 -- int13Minor allele frequency- C:0.06NS WA 96
    rs1179301991,2
    C,F--37528078(+) CTGATA/GGGGTT 1 -- int11Minor allele frequency- G:0.02NA 120
    rs32183221,2
    C,F,A,H--37528098(-) ACGCAG/ATTAGT 1 -- int132Minor allele frequency- A:0.35NS EA NA CSA WA 3492
    rs32183211,2
    C,F,H--37528234(-) TCTAAT/ACCCAG 1 -- int17Minor allele frequency- A:0.02NS EA CSA WA 506
    rs1822994141,2
    --37528317(+) CACTTC/TGGCGT 1 -- int10--------
    rs1155443111,2
    C,F--37528352(+) AATTAG/CCTACT 1 -- int11Minor allele frequency- C:0.08WA 118
    rs20728611,2
    C,F,A,H--37528362(+) TAACCG/TGCCAC 1 -- int123Minor allele frequency- T:0.50EA NS NA WA CSA 3924
    rs2004709161,2
    C--37528414(+) GCCCCG/AGCCTC 1 -- int11Minor allele frequency- A:0.00EU 1265
    rs1396925901,2
    F--37528442(+) CCATGC/ATCTGA 2 /E /D mis11Minor allele frequency- A:0.00NA 4552
    rs96106531,2
    C--37528495(+) CTTCAA/GGACCT 2 L syn1 ese30--------
    rs32183201,2
    C,F,H--37528548(-) CCTTCC/ACTTTC 1 -- int1 trp39Minor allele frequency- A:0.08NS EA WA 998
    rs32183191,2
    C,F--37528570(-) GCCGAT/CGGCAT 1 -- int16Minor allele frequency- C:0.18NS NA WA 216
    rs32183181,2
    C,F,A,H--37528576(-) TGTGGT/CGCCGA 1 -- int123Minor allele frequency- C:0.42NS EA NA WA CSA 2442
    rs20728621,2
    C,F,O,A,H--37528606(+) GAGCCG/ACACCA 1 -- int122Minor allele frequency- A:0.40NS EA NA WA CSA 2442
    rs1854524751,2
    C--37528683(+) TGGGGA/GGACAA 1 -- int10--------
    rs32183171,2
    C,F,H--37528692(-) TGGCCA/CTTCTT 1 -- int119Minor allele frequency- C:0.11NS EA NA WA 2010
    rs1407000281,2
    --37528787(+) GTGGAC/GACAGA 1 -- int10--------
    rs1458084321,2
    --37528814(+) AAGACA/GGGGAG 1 -- int10--------
    rs1383766001,2
    --37528865(+) AGGGAC/TGGAGA 1 -- int10--------
    rs1897195671,2
    --37528901(+) GGAGGC/TGGGAG 1 -- int10--------
    rs1429561091,2
    C--37529308(+) ACATGA/GTTTCC 1 -- int10--------
    rs32183161,2
    C,F,H--37529348(-) CACCCG/ATCCCC 1 -- int113Minor allele frequency- A:0.19NS EA NA WA 2356
    rs1813429761,2
    --37529393(+) GGAAAC/TGGGGC 1 -- int10--------
    rs1505467291,2
    C--37529407(+) GAACAC/GTGCCG 1 -- int10--------
    rs789402521,2
    C,F--37529432(+) AGGACG/AAGGGT 1 -- int11Minor allele frequency- A:0.02NA 120
    rs32183151,2
    C,F,H--37529724(-) TTCGCC/TCTCTG 1 -- int127Minor allele frequency- T:0.35NS EA NA WA CSA 2655
    rs32183621,2
    C,F--37529726(-) acttcG/Accctc 1 -- int12Minor allele frequency- A:0.01NS 90
    rs1855165071,2
    --37529741(+) CCTGTC/GCCACT 1 -- int10--------
    rs1919121521,2
    --37529779(+) GCACAA/CGGCCC 1 -- int10--------
    rs1836004701,2
    --37529797(+) CACCAC/TAGCCT 1 -- int10--------
    rs2289511,2
    C,F,A,H--37529798(-) caggcC/Tgtggt 1 -- int111Minor allele frequency- T:0.49NA NS WA CSA EA 456
    rs32183611,2
    C,F--37529884(-) ctggtG/Atggct 1 -- int14Minor allele frequency- A:0.02NS NA 206
    rs32183601,2
    C--37529901(-) aacagA/Tgtgca 1 -- int13Minor allele frequency- T:0.01NS NA 86
    rs32183591,2
    C--37529902(-) gaacaG/Aagtgc 1 -- int13Minor allele frequency- A:0.01NS NA 86
    rs32183141,2
    C,F,H--37529922(-) AGGAGG/AGAAGA 1 -- int1 trp310Minor allele frequency- A:0.09NS EA NA WA 624
    rs796818671,2
    F--37530027(+) ACAGAA/GTCATC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs32183581,2
    C--37530061(-) GGGGCG/TTGGCC 1 -- int14Minor allele frequency- T:0.04NS NA EA 322
    rs32183131,2
    C,F,H--37530083(-) AACAGG/AGAGGG 1 -- int1 trp36Minor allele frequency- A:0.14NS CSA WA NA EA 432
    rs1492526151,2
    C--37530109(+) AGTCAA/GCACTC 1 -- int10--------
    rs1886354621,2
    --37530121(+) GGATCA/CGTGGG 1 -- int10--------
    rs1920458271,2
    --37530236(+) GCATAA/TCAACT 1 -- int10--------
    rs1839855761,2
    --37530243(+) AACTAC/TTTACA 1 -- int10--------
    rs2289521,2
    C,F,A--37530262(-) taataC/Acatgt 1 -- int15Minor allele frequency- A:0.18NS WA NA EA 440
    rs1444282541,2
    --37530285(+) AATCTA/GGGAGA 1 -- int10--------
    rs1397755001,2
    --37530288(+) CTAGGA/GGATGA 1 -- int10--------
    rs1867020141,2
    --37530330(+) ACACGA/CAAATA 1 -- int10--------
    rs32183121,2
    C,F,A,H--37530332(-) aatatT/Ctgcgt 1 -- int119Minor allele frequency- C:0.20NS EA NA CSA WA 2132
    rs1911068841,2
    --37530411(+) AGGCCA/TAGGCG 1 -- int10--------
    rs1840283141,2
    --37530460(+) GCCAAC/TATGGT 1 -- int10--------
    rs32183111,2
    C,F--37530515(-) GCACAC/TGCCAC 1 -- int12Minor allele frequency- T:0.01NS 94
    rs121709161,2
    --37530550(+) atgacA/Gcagga 1 -- int10--------
    rs32183101,2
    C,F--37530629(-) TCACTC/GTGTCA 1 -- int12Minor allele frequency- G:0.03NS 94
    rs1871728031,2
    --37530686(+) GAGACC/TTGAGT 1 -- int10--------
    rs32183081,2
    C,F--37530814(-) CAGGTG/ATGTAA 1 -- int12Minor allele frequency- A:0.01NS 94
    rs1929121721,2
    --37530913(+) GAGCTA/GTACCT 1 -- int10--------
    rs32183071,2
    C,F,H--37531036(-) CTGCTC/TTCAGG 1 -- int18Minor allele frequency- T:0.01NS EA NA 516
    rs1143822651,2
    F--37531090(+) TCCCAC/TCTTCC 1 -- int11Minor allele frequency- T:0.01WA 118
    rs32183571,2
    C,F--37531099(-) AACCCG/AAGGGG 1 -- int1 trp32Minor allele frequency- A:0.01NS 94
    rs1852816441,2
    --37531116(+) ACAGGA/GCCCCC 1 -- int10--------
    rs25435371,2
    C,F,A,H--37531117(-) GGGGGG/ACCCTG 1 -- int111Minor allele frequency- A:0.36NS WA NA CSA EA 462
    rs38307421,2
    C,F--37531257(+) TGTGTGT/-ATGTG 1 -- int12Minor allele frequency- -:0.50CSA 4
    rs1497755921,2
    --37531285(+) GCTTGG/TGTGCG 1 -- int10--------
    rs32183061,2
    C,F--37531289(-) CACACG/ACACAC 1 -- int13Minor allele frequency- A:0.09NS WA 196
    rs1901819941,2
    --37531290(+) TGTGCA/GTGTGT 1 -- int10--------
    rs1456886661,2
    C--37531321(+) GTGCAC/TGTTGG 1 -- int10--------
    rs1162503431,2
    C,F--37531375(+) TGGCCC/TGGTGT 2 R G mis12Minor allele frequency- T:0.01WA NA 4666
    rs1154754231,2
    C,F--37531376(+) GGCCCG/AGTGTT 2 /T syn13Minor allele frequency- A:0.00WA NA EU 5989
    rs2013601221,2
    --37531379(+) CCGGTA/GTTCCT 2 N syn10--------
    rs1407202971,2
    C--37531411(+) TAAGAT/CGATGA 2 /I /V mis11Minor allele frequency- C:0.00NA 4550
    rs2000643741,2
    C--37531430(+) GCCCCA/GCTGAG 2 S syn10--------
    rs2289531,2
    C,F,A,H--37531436(-) GTGGGC/TCTCAG 2 G syn140Minor allele frequency- T:0.42EA NA MN NS WA CSA EU 10580
    rs32183051,2
    C,F,H--37531521(-) CTTCTC/GTAACC 1 -- int113Minor allele frequency- G:0.06NS CSA WA EA EU 1619
    rs1821872611,2
    --37531659(+) TAAAAA/TGAAAT 1 -- int10--------
    rs1459218131,2
    C--37531675(+) GGTGGC/TATTCT 1 -- int10--------
    rs32183041,2
    C,F,H--37531855(-) CTCATC/TGCACC 1 -- int18Minor allele frequency- T:0.03NS EA WA 632
    rs32183031,2
    C,F,H--37531968(-) CTCTCG/AGCCTG 1 -- int113Minor allele frequency- A:0.04NS EA WA 1288
    rs1384755281,2
    --37531969(+) AGGCCA/GAGAGG 1 -- int10--------
    rs32183021,2
    C--37532034(-) CACTCT/GTCTCC 1 -- int13Minor allele frequency- G:0.02NS WA 212
    rs32183011,2
    F--37532061(-) GTTGGG/CGAGGG 1 -- int12Minor allele frequency- C:0.02NS 94
    rs1159652601,2
    C,F--37532062(+) CCTCCC/TCAACT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs32183001,2
    C,F--37532070(-) GCCTTG/CTGAGT 1 -- int14Minor allele frequency- C:0.05NS CSA WA 212
    rs7607201,2
    C,F,A,H--37532090(+) GCCCCG/TTCCCC 1 -- int114Minor allele frequency- T:0.21EA NA NS CSA WA 2204
    rs117055931,2
    C,F,H--37532126(+) AAAGCG/AAGCCC 1 -- int11Minor allele frequency- A:0.03NA 120
    rs22810891,2
    C,F--37532172(+) CTGCTA/GTACCC 1 -- int113Minor allele frequency- G:0.19EA NS NA WA CSA 1711
    rs32182991,2
    C,F--37532207(-) GAGGAG/ACTGCT 1 -- int1 trp37Minor allele frequency- A:0.08NS NA CSA WA EA 458
    rs779905961,2
    C--37532221(+) CAGCCA/GCCCCC 1 -- int10--------
    rs32182981,2
    C,F--37532255(-) TGGGCG/AGCAAG 1 -- int15Minor allele frequency- A:0.15NS WA 216
    rs1470093311,2
    C,F--37532283(+) TGTCCT/CGAAGG 2 /R /G mis11Minor allele frequency- C:0.00NA 4346
    rs1433304631,2
    C,F--37532381(+) TGAGCG/ATCTCC 2 /T /M mis12Minor allele frequency- A:0.00NA EU 5213
    rs32182971,2
    C,F,A,H--37532441(-) GTCTCC/TGACCC 1 -- int125Minor allele frequency- T:0.19NS EA NA CSA WA EU 2962
    rs2019410531,2
    --37532445(+) CGGAGA/TCAGGA 1 -- int10--------
    rs2014507541,2
    C--37532459(+) TCAGCA/GCCCAC 1 -- int10--------
    rs345779161,2
    C--37532506(+) CAGAA-/C/CC  
            
    CCCCC
    1 -- int10--------
    rs32182961,2
    C,F--37532514(-) GGTTGG/AGGGGG 1 -- int18Minor allele frequency- A:0.20NS NA WA EA 458
    rs719190381,2
    C--37532515(+) CCCCC-/C/C   
       C
    /CCC
    AACCC
    2 -- int1 cds10--------
    rs2289541,2
    C,F,A,H--37532665(-) TGGCTA/GTGGAG 1 -- int123Minor allele frequency- G:0.50NS EA NA WA CSA 1528
    rs2289551,2
    C,F,A,H--37532699(-) AGTGCG/AGCGGG 1 -- int110Minor allele frequency- A:0.45NS NA WA CSA EA 444
    rs32183561,2
    C,F,H--37532765(-) GGGCAC/TGGGTG 1 -- int113Minor allele frequency- T:0.02NS EA NA 906
    rs1164203631,2
    F--37532802(+) AGAAAG/CTGGGA 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1411861981,2
    --37532808(+) TGGGAC/TGTCTC 1 -- int10--------
    rs1378553011,2
    C--37532820(+) GCACA-/CCTCTC 1 -- int10--------
    rs1507194971,2
    --37532892(+) TTGCCA/GTGGCA 1 -- int10--------
    rs32183551,2
    C--37532954(-) GGTGTC/TCAGAA 1 -- int14Minor allele frequency- T:0.02NS NA 206
    rs96225501,2
    C,F--37532963(+) CCCAGG/CTGTCC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs1434084131,2
    --37533037(+) CCCCGA/TTGGGT 1 -- int10--------
    rs32182951,2
    C,F,H--37533068(-) CACCCG/AGATAG 1 -- int140Minor allele frequency- A:0.24NS NA EA WA CSA 4064
    rs2289561,2
    C,F,H--37533143(-) caggaA/Gtctca 1 -- int122Minor allele frequency- G:0.11NS EA NA CSA WA 2562
    rs32182941,2
    C,F,H--37533286(-) CGTGCG/CGGCCT 1 -- int126Minor allele frequency- C:0.08NS EA NA CSA WA 2998
    rs1848025411,2
    --37533288(+) GCCCGC/TACGGA 1 -- int10--------
    rs32182931,2
    C,F,H--37533318(-) CTCCAC/TGTGTC 1 -- int19Minor allele frequency- T:0.01NS EA NA WA 630
    rs1882924091,2
    C--37533460(+) AGGACA/GTGGAA 1 -- int10--------
    rs32182921,2
    C,F,H--37533530(-) CAGCCC/GCAGGT 1 -- int115Minor allele frequency- G:0.12NS EA NA 1396
    rs1806981311,2
    --37533543(+) GGGACC/TTCGAC 1 -- int10--------
    rs1472272611,2
    --37533548(+) CTCGAC/TACAAT 1 -- int10--------
    rs32182911,2
    C,F,H--37533564(-) GTCCTG/ATCCCT 1 -- int17Minor allele frequency- A:0.01NS EA CSA 510
    rs2003565971,2
    C--37533607(+) GGTACA/GGACTG 1 -- int10--------
    rs1997297841,2
    --37533618(+) GGCCAC/TATTCT 1 -- int10--------
    rs1492584621,2
    C,F--37533705(+) GAGATT/GTCCCA 2 /E /D mis11Minor allele frequency- G:0.00NA 4550
    rs2014417301,2
    --37533763(+) TGGGGA/GCCATC 2 A V mis10--------
    rs2006979451,2
    --37533783(+) GGAGAC/TAACAG 1 -- int10--------
    rs2289571,2
    C,F,A,H--37533786(-) CCCCTG/CTTGTC 1 -- int127Minor allele frequency- C:0.47NS EA NA WA CSA EU 2686
    rs2289581,2
    C,F,A--37533795(-) CTCCCA/C/GTACCC 1 -- int114NS MN NA WA CSA EA EU 1510
    rs1497244391,2
    C--37533823(+) TCCACC/TTCCCA 1 -- int10--------
    rs32183541,2
    C,F,H--37533866(-) AGGTGG/ATAGCA 1 -- int17Minor allele frequency- A:0.00NS EA NA 504
    rs22840331,2
    C,F,H--37534034(+) CCTACG/AAAATA 1 -- int139Minor allele frequency- A:0.48EA NS NA WA CSA 4938
    rs1487467441,2
    --37534121(+) CTGCTC/GTGTCC 1 -- int10--------
    rs795728071,2
    C,F--37534134(+) GGCACC/TTGGAA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1176871941,2
    F--37534142(+) GAAGAT/CTACCT 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1171688301,2
    C,F--37534176(+) GATGAA/GTGACT 1 -- int11Minor allele frequency- G:0.07EA 120
    rs1423024561,2
    --37534184(+) ACTCAC/TGGCAG 1 -- int10--------
    rs1913695091,2
    --37534213(+) ATTGAC/TCTGAG 1 -- int10--------
    rs1147605821,2
    C,F--37534331(+) CATAAG/CTGATA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs32182901,2
    C,F--37534539(-) CTGACC/GTTGGG 1 -- int15Minor allele frequency- G:0.04NS NA WA 210
    rs1811912161,2
    --37534610(+) GCTGGA/GTGCGT 1 -- int10--------
    rs2289591,2
    C,F,H--37534734(-) ttgtaC/Tctcct 1 -- int1 trp313Minor allele frequency- T:0.05NS EA NA WA 1440
    rs32182891,2
    C,F,H--37534801(-) ACTCAC/TGTTTC 1 -- int18Minor allele frequency- T:0.01NS EA WA 630
    rs2289601,2
    C,F,A--37534947(-) ctcccC/Tggcac 1 -- int1 trp322Minor allele frequency- T:0.49MN NS NA WA CSA EA 1288
    rs32182881,2
    C,F--37534976(-) AGGCCG/ACTCAG 1 -- int18Minor allele frequency- A:0.08NS NA CSA WA EA 458
    rs1144530501,2
    F--37534977(+) TGAGCG/AGCCTT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs2289611,2
    C,F,H--37535070(-) AGCCTT/CTCTCC 1 -- int1 trp312Minor allele frequency- C:0.03MN NS EA NA WA 948
    rs121701171,2
    C,F--37535130(+) TGCCCC/TAGCCC 1 -- int13Minor allele frequency- T:0.08WA CSA 122
    rs1461851181,2
    C,F--37535157(+) CTCACA/G/TGTTCT 3 I L F mis11NA 4542
    rs2000527131,2
    --37535236(+) GTGACA/GATGTC 2 I syn10--------
    rs1179879281,2
    C--37535248(+) ACTGTG/AGTCAG 2 /T syn11Minor allele frequency- A:0.01EA 120
    rs2018173111,2
    --37535270(+) GCAAGA/GGAAGG 1 -- int10--------
    rs22810931,2
    C,F--37535328(+) GCCACC/GGGGAT 1 -- int119Minor allele frequency- G:0.27EA NS NA WA CSA 2509
    rs32182871,2
    C,F,H--37535443(-) ACCATG/ATGGCC 1 -- int16Minor allele frequency- A:0.00NS EA 500
    rs22810941,2
    C,F,H--37535471(+) AACTCC/TGCCAC 1 -- int134Minor allele frequency- A:0.01NS EA NA CSA WA 3843
    rs2289621,2
    C,F,H--37535494(-) GCCTAT/CGTCTG 1 -- int122Minor allele frequency- C:0.02NS NA EA WA CSA 1031
    rs1159194771,2
    F--37535497(+) ACGTAG/AGCAAC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1916864841,2
    --37535661(+) AGGCAC/TGCAAG 1 -- int10--------
    rs1833521401,2
    --37535725(+) TTAGTA/GTGAAA 1 -- int10--------
    rs32182861,2
    C,F,H--37535779(-) TCTTCC/TAGAAA 1 -- int113Minor allele frequency- T:0.05NS EA WA 1270
    rs1468153401,2
    C--37535840(+) CTTAGA/CCCCTC 1 -- int10--------
    rs1861051051,2
    C--37535859(+) CAGCAA/TCCATC 1 -- int10--------
    rs2289631,2
    C,F,A,H--37535948(-) TAAACC/TTGGGC 1 -- int123Minor allele frequency- N:0.01EA NA NS WA CSA 1213
    rs1395622831,2
    --37535997(+) TCTCCA/GAGTCC 1 -- int10--------
    rs81849511,2
    C,H--37536022(+) TGACAG/AAGGGC 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs81849551,2
    C,H--37536302(+) GGCTAG/AATTTT 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1908640811,2
    --37536312(+) TCCCCG/TATGAT 1 -- int10--------
    rs670343521,2
    C--37536327(+) GTCTC-/ATTATTATTATTATT/
    ATTATTATTATTATTATT
    ATTAT
    2 -- int1 cds11NA 2
    rs1493086201,2
    C--37536327(+) GTCTC-/ATTATT
            
    ATTAT
    1 -- int10--------
    rs2020493071,2
    C--37536327(+) GTCTC-/ATTATTAT 1 -- int10--------
    rs581271061,2
    C--37536352(+) TATTA-/TTATTATT
    ATTATTATTA
    CTATT
    1 -- int11Minor allele frequency- TTATTATTATTATTATTA:0.00NA 2
    rs1466439651,2
    --37536352(+) TATTAC/TTATTA 1 -- int10--------
    rs1823618721,2
    --37536541(+) AGAGCC/TTTAGG 1 --