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Aliases for IL2RB Gene

Aliases for IL2RB Gene

  • Interleukin 2 Receptor, Beta 2 3
  • High Affinity IL-2 Receptor Subunit Beta 3 4
  • Interleukin 15 Receptor, Beta 2 3
  • IL-2 Receptor Subunit Beta 3 4
  • IL-2R Subunit Beta 3 4
  • CD122 Antigen 3 4
  • P70-75 3 4
  • IL-2RB 3 4
  • P75 3 4
  • High Affinity IL-2 Receptor Beta Subunit 3
  • IL15RB 3
  • CD122 3

External Ids for IL2RB Gene

Previous HGNC Symbols for IL2RB Gene

  • IL15RB

Previous GeneCards Identifiers for IL2RB Gene

  • GC22M034136
  • GC22M035764
  • GC22M035846
  • GC22M037515
  • GC22M020487

Summaries for IL2RB Gene

Entrez Gene Summary for IL2RB Gene

  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL2RB Gene

IL2RB (Interleukin 2 Receptor, Beta) is a Protein Coding gene. Diseases associated with IL2RB include polyarticular onset juvenile idiopathic arthritis and oligoarticular juvenile arthritis. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding.

UniProtKB/Swiss-Prot for IL2RB Gene

  • Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2

Gene Wiki entry for IL2RB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL2RB Gene

Genomics for IL2RB Gene

Regulatory Elements for IL2RB Gene

Genomic Location for IL2RB Gene

Chromosome:
22
Start:
37,125,838 bp from pter
End:
37,175,054 bp from pter
Size:
49,217 bases
Orientation:
Minus strand

Genomic View for IL2RB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL2RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL2RB Gene

Proteins for IL2RB Gene

  • Protein details for IL2RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14784-IL2RB_HUMAN
    Recommended name:
    Interleukin-2 receptor subunit beta
    Protein Accession:
    P14784
    Secondary Accessions:
    • B2R765

    Protein attributes for IL2RB Gene

    Size:
    551 amino acids
    Molecular mass:
    61117 Da
    Quaternary structure:
    • Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.

    Three dimensional structures from OCA and Proteopedia for IL2RB Gene

neXtProt entry for IL2RB Gene

Proteomics data for IL2RB Gene at MOPED

Post-translational modifications for IL2RB Gene

  • Glycosylation at Asn 29, Asn 43, Asn 71, and Asn 149
  • Modification sites at PhosphoSitePlus

Other Protein References for IL2RB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL2RB (IL2RB)

No data available for DME Specific Peptides for IL2RB Gene

Domains & Families for IL2RB Gene

Protein Domains for IL2RB Gene

Suggested Antigen Peptide Sequences for IL2RB Gene

Graphical View of Domain Structure for InterPro Entry

P14784

UniProtKB/Swiss-Prot:

IL2RB_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • The box 1 motif is required for JAK interaction and/or activation
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
genes like me logo Genes that share domains with IL2RB: view

Function for IL2RB Gene

Molecular function for IL2RB Gene

GENATLAS Biochemistry:
interleukin 2,high affinity receptor,beta chain 70-75kDa,hematopoietic receptor family,expressed in various tissues
UniProtKB/Swiss-Prot Function:
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2

Gene Ontology (GO) - Molecular Function for IL2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity --
GO:0004911 contributes_to interleukin-2 receptor activity TAS 2467293
GO:0005515 protein binding IPI 23104097
GO:0019976 interleukin-2 binding ISS --
genes like me logo Genes that share ontologies with IL2RB: view
genes like me logo Genes that share phenotypes with IL2RB: view

Animal Models for IL2RB Gene

MGI Knock Outs for IL2RB:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL2RB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL2RB Gene

Localization for IL2RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL2RB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL2RB Gene COMPARTMENTS Subcellular localization image for IL2RB gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for IL2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8514792
GO:0009897 external side of plasma membrane ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IL2RB: view

Pathways & Interactions for IL2RB Gene

SuperPathways for IL2RB Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 PEDF Induced Signaling
3 TGF-Beta Pathway
4 Signaling by GPCR
5 Akt Signaling
genes like me logo Genes that share pathways with IL2RB: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Cytokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

SIGNOR curated interactions for IL2RB Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IL2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0006461 protein complex assembly TAS 2467293
GO:0007165 signal transduction TAS 2785715
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IL2RB: view

Drugs & Compounds for IL2RB Gene

(70) Drugs for IL2RB Gene - From: NovoSeek, DGIdb, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma Target, antibody 94,126
Denileukin diftitox Approved, Investigational Pharma binder, Target, agonist 47
Aldesleukin Approved Pharma inhibitor, modulator, Target, agonist 372
Proleukin Approved January 1998 Pharma 0
alemtuzumab Approved, Investigational Pharma Therapeutic Antibodies 293

(53) Additional Compounds for IL2RB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,25 DIHYDROXY VITAMIN D3
12-O-Tetradecanoylphorbol 13-acetate
2,5-Oligoadenylate
aspartate
chloride
genes like me logo Genes that share compounds with IL2RB: view

Transcripts for IL2RB Gene

mRNA/cDNA for IL2RB Gene

Unigene Clusters for IL2RB Gene

Interleukin 2 receptor, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL2RB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL2RB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - - - -
SP3: -
SP4:

Relevant External Links for IL2RB Gene

GeneLoc Exon Structure for
IL2RB
ECgene alternative splicing isoforms for
IL2RB

Expression for IL2RB Gene

mRNA expression in normal human tissues for IL2RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL2RB Gene

This gene is overexpressed in Whole Blood (x18.3) and Spleen (x6.8).

Protein differential expression in normal tissues from HIPED for IL2RB Gene

This gene is overexpressed in NK cells (34.4), Monocytes (26.9), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL2RB Gene



SOURCE GeneReport for Unigene cluster for IL2RB Gene Hs.474787

genes like me logo Genes that share expression patterns with IL2RB: view

Protein tissue co-expression partners for IL2RB Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL2RB Gene

Orthologs for IL2RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL2RB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC510185 35
  • 76.48 (n)
  • 64.36 (a)
IL2RB 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL2RB 35
  • 79.82 (n)
  • 70.55 (a)
IL2RB 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il2rb 35
  • 71.04 (n)
  • 59.36 (a)
Il2rb 16
Il2rb 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL2RB 35
  • 98.91 (n)
  • 98.55 (a)
IL2RB 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il2rb 35
  • 70.17 (n)
  • 60.04 (a)
oppossum
(Monodelphis domestica)
Mammalia IL2RB 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL2RB 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL2RB 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL2RB 36
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il2rb 36
  • 21 (a)
OneToOne
Species with no ortholog for IL2RB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL2RB Gene

ENSEMBL:
Gene Tree for IL2RB (if available)
TreeFam:
Gene Tree for IL2RB (if available)

Paralogs for IL2RB Gene

Pseudogenes.org Pseudogenes for IL2RB Gene

genes like me logo Genes that share paralogs with IL2RB: view

No data available for Paralogs for IL2RB Gene

Variants for IL2RB Gene

Sequence variations from dbSNP and Humsavar for IL2RB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs15696 -- 37,126,016(+) ATTAA(A/G)AGATA utr-variant-3-prime
rs84458 -- 37,129,168(+) GGCAC(C/T)GTTCT intron-variant
rs84459 -- 37,129,280(+) GAGAG(C/T)ACAGC intron-variant
rs84460 -- 37,129,691(-) TCTCC(C/T)TGGTG intron-variant
rs228938 -- 37,126,725(-) ACAAC(A/C)TTCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IL2RB Gene

Variant ID Type Subtype PubMed ID
nsv834187 CNV Loss 17160897
esv34015 CNV Loss 18971310
nsv459882 CNV Gain 19166990
nsv829203 CNV Loss 20364138
nsv915016 CNV Loss 21882294
nsv915017 CNV Gain 21882294

Variation tolerance for IL2RB Gene

Residual Variation Intolerance Score: 73.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL2RB Gene

HapMap Linkage Disequilibrium report
IL2RB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL2RB Gene

Disorders for IL2RB Gene

MalaCards: The human disease database

(15) MalaCards diseases for IL2RB Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
polyarticular onset juvenile idiopathic arthritis
  • juvenile polyarthritis rheumatoid factor negative
oligoarticular juvenile arthritis
  • pauciarticular chronic arthritis
virus associated hemophagocytic syndrome
intravascular large b-cell lymphoma
  • angioendotheliomatosis proliferans systemisata
herpes simplex encephalitis
  • herpetic encephalitis
- elite association
Search IL2RB in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL2RB

Genetic Association Database (GAD)
IL2RB
Human Genome Epidemiology (HuGE) Navigator
IL2RB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL2RB
genes like me logo Genes that share disorders with IL2RB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL2RB Gene

Publications for IL2RB Gene

  1. Optimizing denileukin diftitox (Ontak) therapy. (PMID: 18684057) Duvic M. … Talpur R. (Future Oncol 2008) 23 25 67
  2. Clinical experience with denileukin diftitox (ONTAK). (PMID: 16516670) Foss F. (Semin. Oncol. 2006) 23 25 67
  3. [New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies]. (PMID: 15022409) AguillA^n J.C. … Cuchacovich M. (Rev Med Chil 2003) 23 25 67
  4. Basiliximab interferes with the detection of soluble IL-2 receptor by the Immulite Immunoassay system. (PMID: 12667677) WarlAc M.C. … Metselaar H.J. (J. Immunol. Methods 2003) 23 25 67
  5. [Immune suppression by combination therapy with basiliximab and cyclosporin in high risk keratoplasty. A pilot study]. (PMID: 11840795) Schmitz K. … Behrens-Baumann W. (Ophthalmologe 2002) 23 25 67

Products for IL2RB Gene

Sources for IL2RB Gene

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