Aliases for IL2RB Gene
External Ids for IL2RB Gene
Previous HGNC Symbols for IL2RB Gene
Previous GeneCards Identifiers for IL2RB Gene
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL2RB Gene
IL2RB (Interleukin 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL2RB include Polyarticular Onset Juvenile Idiopathic Arthritis and Oligoarticular Juvenile Arthritis. Among its related pathways are HTLV-I infection and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding.
UniProtKB/Swiss-Prot for IL2RB Gene
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.