Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IL2RB Gene

protein-coding   GIFtS: 68
GCID: GC22M037515

Interleukin 2 Receptor, Beta

(Previous names: interleukin 15 receptor, beta)
(Previous symbol: IL15RB)
  See IL2RB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 2 Receptor, Beta1 2     IL-2R Subunit Beta2 3
IL15RB1 2     p752 3
Interleukin 15 Receptor, Beta1 2     CD1222
High Affinity IL-2 Receptor Subunit Beta2 3     P70-752
IL-2RB2 3     High Affinity IL-2 Receptor Beta Subunit2
CD122 Antigen2 3     Interleukin-2 Receptor Subunit Beta2
IL-2 Receptor Subunit Beta2 3     p70-753

External Ids:    HGNC: 60091   Entrez Gene: 35602   Ensembl: ENSG000001003857   OMIM: 1467105   UniProtKB: P147843   
ORGUL members:         

Export aliases for IL2RB gene to outside databases

Previous GC identifers: GC22M034136 GC22M035764 GC22M035846 GC22M020487


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IL2RB Gene:
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with
respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not
involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer,
while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high
affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic
signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane
protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL2RB Gene:
IL2RB (interleukin 2 receptor, beta) is a protein-coding gene. Diseases associated with IL2RB include extramedullary plasmacytoma, and occipital neuralgia. GO annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding.

UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784
Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and
transduces the mitogenic signals of IL2

Gene Wiki entry for IL2RB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL2RB gene promoter:
         Elk-1   GATA-3   STAT5A   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL2RB promoter sequence
   Search Chromatin IP Primers for IL2RB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL2RB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13

IL2RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL2RB gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037515:  view genomic region     (about GC identifiers)

Start:
37,521,878 bp from pter      End:
37,571,094 bp from pter
Size:
49,217 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784 (See protein sequence)
Recommended Name: Interleukin-2 receptor subunit beta precursor  
Size: 551 amino acids; 61117 Da
Subunit: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity
dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and
intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.
Interacts with HTLV-1 accessory protein p12I
6 PDB 3D structures from and Proteopedia for IL2RB:
1ILM (3D)        1ILN (3D)        2B5I (3D)        2ERJ (3D)        3QAZ (3D)        4GS7 (3D)    
Secondary accessions: B2R765

Explore the universe of human proteins at neXtProt for IL2RB: NX_P14784

Explore proteomics data for IL2RB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29, Asn43, Asn71, Asn149
  • Modification sites at PhosphoSitePlus

  • See IL2RB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000869.1  
    ENSEMBL proteins: 
     ENSP00000216223   ENSP00000403731   ENSP00000402685   ENSP00000400416   ENSP00000401020  
    Reactome Protein details: P14784

    IL2RB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL2RB (IL-2 R beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL2RB
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL2RB
    GenScript Custom Purified and Recombinant Proteins Services for IL2RB
    Novus Biologicals IL2RB Proteins
    Novus Biologicals IL2RB Lysates
    Sino Biological Recombinant Protein for IL2RB
    Sino Biological Cell Lysate for IL2RB
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IL2RB 

    IL2RB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL2RB (IL-2 R beta)
    Cell Signaling Technology (CST) Antibodies for IL2RB 
    OriGene Antibodies for IL2RB
    OriGene Custom Antibody Services for IL2RB
    Novus Biologicals IL2RB Antibodies
    Abcam antibodies for IL2RB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for IL2RB
    LSBio Antibodies in human, mouse, rat for IL2RB

    IL2RB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL2RB
    R&D Systems Proteome Profiler Antibody Arrays for IL2RB (IL-2 R beta)
    GenScript Custom Assay Services for IL2RB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IL2RB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-2 receptor beta subunit
    IL-2 receptor family

    3 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003531 Hempt_rcpt_S_F1_CS

    Graphical View of Domain Structure for InterPro Entry P14784

    ProtoNet protein and cluster: P14784

    1 Blocks protein domain: IPB003531 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily
    Similarity: Contains 1 fibronectin type-III domain


    Find genes that share domains with IL2RB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL2RB_HUMAN, P14784
    Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and
    transduces the mitogenic signals of IL2

         Genatlas biochemistry entry for IL2RB:
    interleukin 2,high affinity receptor,beta chain 70-75kDa,hematopoietic receptor family,expressed in various
    tissues

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004911contributes to interleukin-2 receptor activity TAS2467293
    GO:0005515protein binding ----
    GO:0019976interleukin-2 binding ISS--
         
    Find genes that share ontologies with IL2RB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL2RB:
     Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il2rb):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     immune system  integument  liver/biliary system  mortality/aging  reproductive system 

    Find genes that share phenotypes with IL2RB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il2rbtm1Mak for IL2RB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL2RB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL2RB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL2RB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL2RB

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL2RB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL2RB (see all 11):
    hsa-miR-146b-3p hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-24 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidIL2RB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL2RB
    Predesigned siRNA for gene silencing in human, mouse, rat IL2RB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL2RB

    Clone
    Products:
         
    OriGene clones in human, mouse for IL2RB (see all 5)
    OriGene ORF clones in mouse, rat for IL2RB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL2RB (NM_000878)
    Sino Biological Human cDNA Clone for IL2RB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL2RB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2RB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL2RB
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL2RB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RB

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12551) for IL2RB 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IL2RB_HUMAN, P14784: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8514792
    GO:0009897external side of plasma membrane ISS--

    Find genes that share ontologies with IL2RB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IL2RB About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    NFAT Signaling and Lymphocyte Interactions0.57
    Glucocorticoid Receptor Signaling0.43
    PGC1Alpha Pathway0.51
    Cytokine-cytokine receptor interaction0.43
    STAT3 Pathway0.47
    2IL2-mediated signaling events
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    4Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60


    Find genes that share SuperPaths with IL2RB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for IL2RB
        IL-2 Signaling Pathways
    IL-15 Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL2RB (see all 15)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    ICos-ICosL Pathway in T-Helper Cell

    2 Cell Signaling Technology (CST) Pathways for IL2RB
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for IL2RB
        Immune response IL-22 signaling pathway
    Immune response IL-2 activation and signaling pathway

    Selected BioSystems Pathways for IL2RB (see all 8)
        IL-5 Signaling Pathway
    IL-2 Signaling pathway
    IL2 signaling events mediated by PI3K
    IL2-mediated signaling events
    IL12-mediated signaling events


    2 Reactome Pathways for IL2RB
        Interleukin receptor SHC signaling
    Interleukin-2 signaling


    Selected Kegg Pathways  (Kegg details for IL2RB) (see all 7):
        Cytokine-cytokine receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Measles

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2RB: 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL2RB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL2RB (P147842, 3 ENSP000002162234) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT5AP422292, 3, ENSP000003412084MINT-8035160 I2D: score=4 STRING: ENSP00000341208
    STAT5BP516922, 3, ENSP000002933284MINT-8035171 I2D: score=4 STRING: ENSP00000293328
    SHBQ154642, 3, ENSP000003669364MINT-8035186 I2D: score=3 STRING: ENSP00000366936
    GNB2L1P632443, ENSP000003660134I2D: score=4 STRING: ENSP00000366013
    SHC1P293533, ENSP000004013034I2D: score=4 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS2467293
    GO:0007165signal transduction TAS2785715
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0019221cytokine-mediated signaling pathway IDA7736574

    Find genes that share ontologies with IL2RB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL2RB

    4 DrugBank Compounds for IL2RB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aldesleukin
    • IL-2
    • Interleukin-2 precursor
    • T-cell growth factor
    • TCGF
    (see top 1)
    85898-30-2targetagonist modulator16542139 16617454 16569767 11752352 16477002 16596189
    Basiliximab
    • chimeric mouse-human antiCD25
    • Ig gamma-1 chain C region
    (see top 1)
    152923-56-3targetantibody11840795 11752352 12826150 10188761 12667677 10708100
    Daclizumab
    • Anti-IL-2
    • Humanized antiCD25
    • Ig gamma-1 chain C region
    (see top 1)
    152923-56-3targetantibody15022409 2571203 11752352 2647626 12372041 15814281
    Denileukin diftitox
    • Diphtheria toxin precursor
    • DT
    • NAD(+--diphthamide ADP- ribosyltransferase)
    (see top 1)
    173146-27-5targetagonist16516670 15811959 11752352 17187516 18684057

    Selected Novoseek inferred chemical compound relationships for IL2RB gene (see all 118)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    daclizumab 75.5 25 11359452 (2), 20415630 (2), 9794841 (1), 11004222 (1) (see all 21)
    neopterin 74.5 56 9892527 (5), 7647844 (3), 17975200 (2), 1606739 (2) (see all 41)
    okt3 66.8 13 2148645 (2), 2121373 (2), 1916932 (1), 8027539 (1) (see all 9)
    denileukin diftitox 65.3 12 15353540 (1), 19707452 (1), 16410787 (1), 18295790 (1) (see all 6)
    basiliximab 62.4 14 12667677 (2), 11840795 (2), 10188761 (1), 17150025 (1) (see all 10)
    cyclosporin a 58.7 30 1864010 (2), 1864013 (1), 1346344 (1), 7509146 (1) (see all 26)
    r-il-2 53.8 1 7576120 (1)
    thymoglobulin 53.4 7 15041353 (1), 15575919 (1), 17927304 (1), 19236436 (1) (see all 7)
    ionomycin 50.8 5 8344700 (1), 1654606 (1), 2017664 (1), 11347470 (1) (see all 5)
    tyrosine 50.4 68 1639773 (3), 8089104 (3), 2007186 (3), 7612266 (2) (see all 50)



    Find genes that share compounds with IL2RB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IL2RB gene: 
    NM_000878.3  

    Unigene Cluster for IL2RB:

    Interleukin 2 receptor, beta
    Hs.474787  [show with all ESTs]
    Unigene Representative Sequence: NM_000878
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216223(uc003aqv.1) ENST00000483573 ENST00000453962 ENST00000429622
    ENST00000461607 ENST00000440958 ENST00000445595
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL2RB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL2RB (see all 11):
    hsa-miR-146b-3p hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-24 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidIL2RB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL2RB
    Predesigned siRNA for gene silencing in human, mouse, rat IL2RB
    Clone
    Products:
         
    OriGene clones in human, mouse for IL2RB (see all 5)
    OriGene ORF clones in mouse, rat for IL2RB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL2RB (NM_000878)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL2RB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2RB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL2RB
    OriGene qSTAR qPCR primer pairs in human, mouse for IL2RB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL2RB
      QuantiTect SYBR Green Assays in human, mouse, rat IL2RB
      QuantiFast Probe-based Assays in human, mouse, rat IL2RB
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12551) for IL2RB 

    Additional mRNA sequence: 

    AK312860.1 BC025691.1 CR456506.1 M26062.1 

    7 DOTS entries:

    DT.312677  DT.120651820  DT.120651728  DT.120651741  DT.91695341  DT.65286096  DT.91692959 

    Selected AceView cDNA sequences (see all 209):

    BX378224 H55712 BQ707555 NM_182486 BQ053622 AL708630 CR606760 BC025691 
    AI968918 BQ008149 BQ053441 CR456506 AK128125 BF223041 T28565 H55257 
    BM722009 BX339049 CD633231 AI989994 H55722 M26062 BU859813 NM_000878 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL2RB    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                          -                       -                                             
    SP2:                          -           -     -     -     -                                       
    SP3:                          -                                                                     
    SP4:                                                                                                


    ECgene alternative splicing isoforms for IL2RB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IL2RB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTCCTG
    IL2RB Expression
    About this image


    IL2RB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Natural Killer Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    IL2RB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL2RB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474787
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2RB: 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL2RB
    OriGene qSTAR qPCR primer pairs in human, mouse for IL2RB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL2RB
    QuantiTect SYBR Green Assays in human, mouse, rat IL2RB
    QuantiFast Probe-based Assays in human, mouse, rat IL2RB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IL2RB gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il2rb1 , 5 interleukin 2 receptor, beta chain1, 5 71.04(n)1
    59.36(a)1
      15 (37.52 cM)5
    161851  NM_008368.41  NP_032394.11 
     784805535 
    chicken
    (Gallus gallus)
    Aves IL2RB6
    interleukin 2 receptor, beta
    31(a)
    1 ↔ 1
    1(51302272-51314508)
    lizard
    (Anolis carolinensis)
    Reptilia IL2RB6
    interleukin 2 receptor, beta
    25(a)
    1 ↔ 1
    5(22752570-22783364)
    zebrafish
    (Danio rerio)
    Actinopterygii il2rb6
    interleukin 2 receptor, beta
    21(a)
    1 ↔ 1
    3(25292633-25310273) ENSDARG00000075720


    ENSEMBL Gene Tree for IL2RB (if available)
    TreeFam Gene Tree for IL2RB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IL2RB gene

    Find genes that share paralogs with IL2RB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IL2RB
    PGOHUM00000250326


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IL2RB (see all 720)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32183361,2
    C,F,H--37521478(-) CCAGAC/TCAGGG 1 -- ds50016Minor allele frequency- T:0.01NS EA 504
    rs1451375261,2
    --37521544(+) GGGGG-/ATAGAG 1 -- ds50010--------
    rs588099631,2
    C--37521546(+) TAGAG-/A/GAG 
     
    /GAGAGG
    GGGGG
    3 -- ds5001 cds10--------
    rs2015612361,2
    --37521548(+) GATAG-/AGGGGG 1 -- ds50010--------
    rs1468544241,2
    C--37521646(+) TATTT-/CCCCAG 1 -- ds50010--------
    rs32183351,2
    C,F--37521662(-) TCCCAC/TAAGTC 1 -- ds50012Minor allele frequency- T:0.01NS 82
    rs1862350861,2
    --37521670(+) GGATAA/TGGCCA 1 -- ds50010--------
    rs1889496841,2
    --37521802(+) GTCTTC/TGACAG 1 -- ds50010--------
    rs1813940081,2
    --37521838(+) TTTAAG/TAGACA 1 -- ds50010--------
    rs1858205031,2
    C--37521859(+) CGCAGA/GCAATG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for IL2RB (37521878 - 37571094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IL2RB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34015CNV Loss18971310
    nsv829203CNV Loss20364138
    nsv915016CNV Loss21882294
    nsv834187CNV Loss17160897
    nsv915017CNV Gain21882294
    nsv459882CNV Gain19166990

    Human Gene Mutation Database (HGMD): IL2RB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL2RB
    DNA2.0 Custom Variant and Variant Library Synthesis for IL2RB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 146710    OMIM disorders: --

    Selected diseases for IL2RB (see all 21):    
    About MalaCards
    extramedullary plasmacytoma    occipital neuralgia    granulomatous orchitis    orchitis
    berylliosis    central pontine myelinolysis    oligoarticular juvenile arthritis    polyarticular onset juvenile idiopathic arthritis
    polymyalgia rheumatica    primary malignant lymphoma    graft versus host disease    posterior uveitis
    dermatitis herpetiformis    infectious mononucleosis    mycosis fungoides    intravascular large b-cell lymphoma
    herpes simplex encephalitis    uveitis    epidermolysis bullosa acquisita    malaria


    Find genes that share disorders with IL2RB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL2RB gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency, x-linked 72.6 11 16138102 (1), 7718508 (1), 7523745 (1), 7632950 (1) (see all 9)
    necrosis 63.9 160 11505128 (2), 1910217 (2), 9060545 (2), 8146526 (2) (see all 99)
    tumors 50 172 16996570 (3), 8146526 (3), 10685665 (3), 11505128 (2) (see all 99)
    autoimmune diseases 48.2 17 1934612 (1), 8580481 (1), 15528977 (1), 2081786 (1) (see all 17)
    leukemia hairy cell 47.8 5 2072745 (1), 8107487 (1), 8329708 (1), 1700727 (1) (see all 5)
    leukemia t-cell 45.9 6 8102412 (1), 1379847 (1), 2298500 (1), 8648694 (1) (see all 5)
    diphtheria 45.7 7 15353540 (1), 16586495 (1), 9796831 (1), 16410787 (1) (see all 7)
    metastatic melanoma 41.9 1 10711641 (1)
    htlv-i infections 41.8 1 1982452 (1)
    rheumatoid arthritis 41.4 15 2289327 (2), 7738942 (2), 8039284 (2), 7921769 (1) (see all 12)

    Genetic Association Database (GAD): IL2RB
    Human Genome Epidemiology (HuGE) Navigator: IL2RB (39 documents)

    Export disorders for IL2RB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IL2RB gene, integrated from 10 sources (see all 1217):
    (articles sorted by number of sources associating them with IL2RB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. (PubMed id 16477002)1, 2, 7 Stauber D.J.... Wilson I.A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. IL-2 receptor signaling through the Shb adapter protein in T and NK cells. (PubMed id 12200137)1, 2, 9 Lindholm C.K. (Biochem. Biophys. Res. Commun. 2002)
    3. Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis. (PubMed id 17108990)1, 4, 9 Bucheton B....Dessein A.J. (Genes Immun. 2007)
    4. IL-2 gene C/T polymorphism is associated with prostate cancer. (PubMed id 17115417)1, 4, 9 Wu H.C....Chen W.C. (J. Clin. Lab. Anal. 2006)
    5. The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface. (PubMed id 8648694)1, 2, 9 Mulloy J.C.... Franchini G. (J. Virol. 1996)
    6. Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways. (PubMed id 21653640)1, 4 Eleftherohorinou H....Coin L.J. (Hum. Mol. Genet. 2011)
    7. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1, 4 Hildebrandt M.A....Wu X. (PLoS ONE 2010)
    10. Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. (PubMed id 20498205)1, 4 Plant D....Worthington J. (Ann. Rheum. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3560 HGNC: 6009 AceView: IL2RBandC1QTNF6 Ensembl:ENSG00000100385 euGenes: HUgn3560
    ECgene: IL2RB Kegg: 3560 H-InvDB: IL2RB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IL2RB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL2RB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il2rb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IL2RB gene:
    Search GeneIP for patents involving IL2RB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for IL2RB (IL-2 R beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for IL2RB (IL-2 R beta)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for IL2RB (IL-2 R beta)  
     OriGene Antibodies for IL2RB   OriGene RNAi products in human, mouse, rat for IL2RB  
     OriGene qPCR primer pairs and template standards for IL2RB   OriGene Protein Over-expression Lysate for IL2RB  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IL2RB  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL2RB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IL2RB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL2RB   OriGene Custom Protein Services for IL2RB  

     
     
     Block miRNA regulation of human, mouse, rat IL2RB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IL2RB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL2RB Predesigned siRNA for gene silencing in human, mouse, rat IL2RB
     QuantiFast Probe-based Assays in human, mouse, rat IL2RB QuantiTect SYBR Green Assays in human, mouse, rat IL2RB
     PCR Arrays including human, mouse, rat IL2RB Search Chromatin IP Primers for IL2RB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL2RB  GeneGlobe Interaction Network for IL2RB
     Regulatory tfbs in IL2RB promoter
     GenScript Custom Purified and Recombinant Proteins Services for IL2RB GenScript cDNA clones with any tag delivered in your preferred vector for IL2RB
     GenScript Custom Assay Services for IL2RB GenScript Custom overexpressing Cell Line Services for IL2RB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for IL2RB 

     Search Tocris compounds for IL2RB
     Proteins for IL2RB
     Cell Lysates for IL2RB
     cDNA Clones for IL2RB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IL2RB antibodies
     IL2RB proteins
     IL2RB lysates
     Antibodies for IL2RB
     See all of Abcam's Antibodies, Kits and Proteins for IL2RB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IL2RB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RB
     SwitchGear 3'UTR luciferase reporter plasmids for IL2RB
     SwitchGear Promoter luciferase reporter plasmids for IL2RB
     ThermoFisher Antibodies for IL2RB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2RB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL2RB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL2RB
     LSBio Antibodies in human, mouse, rat for IL2RB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for IL2RB
      Search eBioscience for proteins for IL2RB
      Search eBioscience for elisas for IL2RB
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL2RB gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4