Aliases for IL2RB Gene
External Ids for IL2RB Gene
Previous HGNC Symbols for IL2RB Gene
Previous GeneCards Identifiers for IL2RB Gene
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL2RB Gene
IL2RB (Interleukin 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL2RB include polyarticular onset juvenile idiopathic arthritis and oligoarticular juvenile arthritis. Among its related pathways are PEDF Induced Signaling and Endocytosis. GO annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding.
UniProtKB/Swiss-Prot for IL2RB Gene
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.