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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL2RB Gene

protein-coding GIFtS: 66
GCID: GC22M037515

interleukin 2 receptor, beta

(Previous names: interleukin 15 receptor, beta )
(Previous symbol: IL15RB)

Explore 179 diseases affiliated with
IL2RB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 2 Receptor, Beta¹ ²		IL-2 Receptor Subunit Beta² ³
CD122¹ ²		IL-2R Subunit Beta² ³
IL15RB¹ ²		P75¹
Interleukin 15 Receptor, Beta¹ ²		P70-75²
High Affinity IL-2 Receptor Subunit Beta² ³		High Affinity IL-2 Receptor Beta Subunit²
IL-2RB² ³		Interleukin-2 Receptor Subunit Beta²
CD122 Antigen² ³		P70-75²

External Ids:	HGNC: 6009¹	Entrez Gene: 3560²	Ensembl: ENSG00000100385⁷	OMIM: 146710⁵	UniProtKB: P14784³

Export aliases for IL2RB gene to outside databases

Previous GC identifers: GC22M034136 GC22M035764 GC22M035846 GC22M020487

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL2RB:

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect

to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in

signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high

affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of

the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.

The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784

Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the

mitogenic signals of IL2

Gene Wiki entry for IL2RB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL2RB gene promoter:
Elk-1 GATA-3 STAT5A GATA-2 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL2RB promoter sequence

Search SABiosciences Chromatin IP Primers for IL2RB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL2RB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13

IL2RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL2RB gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M037515: view genomic region (about GC identifiers)

Start:	37,515,126 bp from pter	End:	37,571,094 bp from pter
Size:	55,969 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784 (See protein sequence)

Recommended Name: Interleukin-2 receptor subunit beta precursor

Size: 551 amino acids; 61117 Da

Subunit: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an

intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate

affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with

HTLV-1 accessory protein p12I

Subcellular location: Membrane; Single-pass type I membrane protein

6 PDB 3D structures from and Proteopedia for IL2RB:

1ILM (3D)

1ILN (3D)

2B5I (3D)

2ERJ (3D)

3QAZ (3D)

4GS7 (3D)

Secondary accessions: B2R765

Explore the universe of human proteins at neXtProt for IL2RB: NX_P14784

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14784

IL2RB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000869.1

ENSEMBL proteins:

ENSP00000392447 ENSP00000216223 ENSP00000403731 ENSP00000402685 ENSP00000400416

ENSP00000401020

Reactome Protein details: P14784
Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for IL2RB
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	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8514792
GO:0009897	external side of plasma membrane	ISS	--

IL2RB for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL2RB for domains About GeneDecksing

3 InterPro domains/families:

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

IPR003531 Hempt_rcpt_S_F1_CS

Graphical View of Domain Structure for InterPro Entry P14784

ProtoNet protein and cluster: P14784

1 Blocks protein family: IPB003531 Short hematopoietin receptor

UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular

transport and cell-surface receptor binding

Domain: The box 1 motif is required for JAK interaction and/or activation

Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily

Similarity: Contains 1 fibronectin type-III domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL2RB_HUMAN, P14784

Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the

mitogenic signals of IL2

Genatlas biochemistry entry for IL2RB:

interleukin 2,high affinity receptor,beta chain 70-75kDa,hematopoietic receptor family,expressed in various tissues

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL2RB
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate IL2RB (see all 11):
		hsa-miR-146b-3p hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-24 hsa-miR-195 hsa-miR-16 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: IL2RB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RB

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0004911	contributes to interleukin-2 receptor activity	TAS	2467293
GO:0019976	interleukin-2 binding	ISS	--

IL2RB for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL2RB:

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Il2rb^tm1Mak for IL2RB
11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Il2rb):

behavior/neurological	cellular	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	immune system	integument	liver/biliary system	mortality/aging
reproductive system

IL2RB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Interleukin receptor SHC signaling

Interleukin receptor SHC signaling	1.00	SHC1 mediates cytokine-induced phosphorylation of GAB2	0.61
Interleukin-2 signaling	0.67	Interleukin-3, 5 and GM-CSF signaling	0.57
Phosphorylated SHC1 recruits GRB2:GAB2	0.61	Signaling by Interleukins	0.25

PEDF Induced Signaling

STAT3 Pathway	0.47	Glucocorticoid Receptor Signaling	0.27
NFAT Signaling and Lymphocyte Interactions	0.37	Cytokine-cytokine receptor interaction	0.26
PGC1Alpha Pathway	0.33

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Immune response IL-22 signaling pathway

Immune response IL-22 signaling pathway

1.00

Immune response_IL-22 signaling pathway

0.87

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IL2RB

	Immune response IL-22 signaling pathway
	Immune response IL-2 activation and signaling pathway

4 R&D Systems Pathways for IL2RB

	IL-2 Signaling Pathways
	IL-15 Signaling Pathways
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL2RB (see all 15)

	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Glucocorticoid Receptor Signaling
	ICos-ICosL Pathway in T-Helper Cell

2 Cell Signaling Technology (CST) Pathways for IL2RB

	Lymphocyte Signaling
	Tyrosine Kinases / Adaptors

2 GeneGo (Thomson Reuters) Pathways for IL2RB

	Immune response IL-22 signaling pathway
	Immune response IL-2 activation and signaling pathway

5/8 BioSystems Pathways for IL2RB (see all 8)

	IL-5 Signaling Pathway
	IL-2 Signaling Pathway
	IL2-mediated signaling events
	Downstream signaling in naive CD8+ T cells
	IL2 signaling events mediated by PI3K

5/8 Reactome Pathways for IL2RB (see all 8)

	SHC1 mediates cytokine-induced phosphorylation of GAB2
	Interleukin receptor SHC signaling
	Interleukin-2 signaling
	Phosphorylated SHC1 recruits GRB2:GAB2
	Cytokine Signaling in Immune system

4 Kegg Pathways (Kegg details for IL2RB):

	Cytokine-cytokine receptor interaction
	Endocytosis
	Jak-STAT signaling pathway
	Measles

IL2RB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL2RB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/91 Interacting proteins for IL2RB (P14784^{2, 3} ENSP00000216223⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 91)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAT5A	P42229²^,³, ENSP00000341208⁴	MINT-8035160 I2D: score=4 STRING: ENSP00000341208
STAT5B	P51692²^,³, ENSP00000293328⁴	MINT-8035171 I2D: score=4 STRING: ENSP00000293328
SHB	Q15464²^,³, ENSP00000366936⁴	MINT-8035186 I2D: score=3 STRING: ENSP00000366936
GNB2L1	P63244³, ENSP00000366013⁴	I2D: score=4 STRING: ENSP00000366013
SHC1	P29353³, ENSP00000401303⁴	I2D: score=4 STRING: ENSP00000401303

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	TAS	2467293
GO:0007165	signal transduction	TAS	2785715
GO:0019048	virus-host interaction	IEA	--
GO:0019221	cytokine-mediated signaling pathway	IDA	7736574
GO:0038110	interleukin-2-mediated signaling pathway	TAS	2467293

IL2RB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL2RB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL2RB

4 DrugBank Compounds for IL2RB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Aldesleukin	IL-2 (see all 4)	85898-30-2	target	agonist modulator	16542139 16617454 16569767 11752352 16477002 16596189
Basiliximab	chimeric mouse-human antiCD25 (see all 2)	152923-56-3	target	antibody	11840795 11752352 12826150 10188761 12667677 10708100
Daclizumab	Anti-IL-2 (see all 3)	152923-56-3	target	antibody	15022409 2571203 11752352 2647626 12372041 15814281
Denileukin diftitox	Diphtheria toxin precursor (see all 3)	173146-27-5	target	agonist	16516670 15811959 11752352 17187516 18684057

10/118 Novoseek chemical compound relationships for IL2RB gene (see all 118) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
daclizumab	75.5	25	11359452 (2), 20415630 (2), 9794841 (1), 11004222 (1) (see all 21)
neopterin	74.5	56	9892527 (5), 7647844 (3), 17975200 (2), 1606739 (2) (see all 41)
okt3	66.8	13	2148645 (2), 2121373 (2), 1916932 (1), 8027539 (1) (see all 9)
denileukin diftitox	65.3	12	15353540 (1), 19707452 (1), 16410787 (1), 18295790 (1) (see all 6)
basiliximab	62.4	14	12667677 (2), 11840795 (2), 10188761 (1), 17150025 (1) (see all 10)
cyclosporin a	58.7	30	1864010 (2), 1864013 (1), 1346344 (1), 7509146 (1) (see all 26)
r-il-2	53.8	1	7576120 (1)
thymoglobulin	53.4	7	15041353 (1), 15575919 (1), 17927304 (1), 19236436 (1) (see all 7)
ionomycin	50.8	5	8344700 (1), 1654606 (1), 2017664 (1), 11347470 (1) (see all 5)
tyrosine	50.4	68	1639773 (3), 8089104 (3), 2007186 (3), 7612266 (2) (see all 50)

Search CenterWatch for drugs/clinical trials and news about IL2RB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL2RB gene:

NM_000878.3

Unigene Cluster for IL2RB:

Interleukin 2 receptor, beta

Hs.474787 [show with all ESTs]

Unigene Representative Sequence: NM_000878

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000447922 ENST00000216223(uc003aqv.1) ENST00000483573 ENST00000453962

ENST00000429622 ENST00000461607 ENST00000440958 ENST00000445595

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		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate IL2RB (see all 11):
		hsa-miR-146b-3p hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-24 hsa-miR-195 hsa-miR-16 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: IL2RB 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL2RB (see all 7) OriGene shRNA RFP: IL2RB OriGene siRNA: IL2RB
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL2RB

Additional cDNA sequence:

AK312860.1 BC025691.1 CR456506.1 M26062.1

7 DOTS entries:

DT.312677 DT.120651820 DT.120651728 DT.120651741 DT.91695341 DT.65286096 DT.91692959

24/209 AceView cDNA sequences (see all 209):

H55722 AL708630 BF223041 BQ008149 NM_031910 CD633231 AY358374 BU542015

BU859813 H55257 BC025691 T28565 AI989994 BM722009 H55712 BX339049

CR606760 NM_182486 BU857654 BQ707555 AI968918 M26062 BQ712725 AK128125

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IL2RB About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10
SP1:									-								-
SP2:									-				-		-		-		-
SP3:									-
SP4:

ECgene alternative splicing isoforms for IL2RB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL2RB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCCTCCTG

About this image

IL2RB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Peripheral Blood

Natural Killer Cells

Selective marker (cell-identifying gene)

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IL2RB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL2RB

SOURCE GeneReport for Unigene cluster: Hs.474787

SABiosciences Expression via Pathway-Focused PCR Arrays including IL2RB:

Interferons & Receptors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL2RB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL2RB gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IL2RB⁶	Uncharacterized protein	29(a)	1 ↔ 1	1(53430349-53440124)
lizard (Anolis carolinensis)	Reptilia	IL2RB⁶	--	33(a)	1 ↔ 1	5(22756911-22762393)
zebrafish (Danio rerio)	Actinopterygii	il2rb¹	interleukin 2 receptor, beta	43.52(n) 32.22(a)		793920 NM_001128267.1 NP_001121739.1

ENSEMBL Gene Tree for IL2RB (if available)
TreeFam Gene Tree for IL2RB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for IL2RB gene

IL2RB for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for IL2RB
PGOHUM00000250326

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3218336^1,2	C,F,H,	--	37521478(-)	`CCAGAC/TCAGGG`	1	--	ds500¹		6		NS EA	504
rs145137526^1,2		--	37521544(+)	`GGGGG-/ATAGAG`	1	--	ds500¹		0	--	--	--	--
rs58809963^1,2	C,	--	37521548(+)	`TAGAG-/AGGGGG`	1	--	ds500¹		0	--	--	--	--
rs201561236^1,2		--	37521548(+)	`GATAG-/AGGGGG`	1	--	ds500¹		0	--	--	--	--
rs146854424^1,2	C,	--	37521646(+)	`TATTT-/CCCCAG`	1	--	ds500¹		0	--	--	--	--
rs3218335^1,2	C,	--	37521662(-)	`TCCCAC/TAAGTC`	1	--	ds500¹		2		NS	82
rs186235086^1,2		--	37521670(+)	`GGATAA/TGGCCA`	1	--	ds500¹		0	--	--	--	--
rs188949684^1,2		--	37521802(+)	`GTCTTC/TGACAG`	1	--	ds500¹		0	--	--	--	--
rs181394008^1,2		--	37521838(+)	`TTTAAG/TAGACA`	1	--	ds500¹		0	--	--	--	--
rs185820503^1,2		--	37521859(+)	`CGCAGA/GCAATG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL2RB (37515126 - 37571094 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL2RB
1 CNV: 47855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL2RB for disorders           About GeneDecksing

OMIM gene information: 146710    OMIM disorders: --

20/179 diseases for IL2RB (see all 179):    About MalaCards

graft versus host disease central pontine myelinolysis polymyalgia rheumatica epidermolysis bullosa acquisita

b-cell non-hodgkin lymphoma severe combined immunodeficiency common variable immunodeficiency diffuse large b-cell lymphoma

human t-cell leukemia virus type 1 acute graft versus host disease thrombotic thrombocytopenic purpura non-hodgkin lymphoma

epidermolysis bullosa occipital neuralgia tropical spastic paraparesis infectious mononucleosis

mycosis fungoides dermatitis herpetiformis large granular lymphocyte leukemia extramedullary plasmacytoma

10/94 Novoseek disease relationships for IL2RB gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
severe combined immunodeficiency, x-linked	72.6	11	16138102 (1), 7718508 (1), 7523745 (1), 7632950 (1) (see all 9)
necrosis	63.9	160	11505128 (2), 1910217 (2), 9060545 (2), 8146526 (2) (see all 99)
tumors	50	172	16996570 (3), 8146526 (3), 10685665 (3), 11505128 (2) (see all 99)
autoimmune diseases	48.2	17	1934612 (1), 8580481 (1), 15528977 (1), 2081786 (1) (see all 17)
leukemia hairy cell	47.8	5	2072745 (1), 8107487 (1), 8329708 (1), 1700727 (1) (see all 5)
leukemia t-cell	45.9	6	8102412 (1), 1379847 (1), 2298500 (1), 8648694 (1) (see all 5)
diphtheria	45.7	7	15353540 (1), 16586495 (1), 9796831 (1), 16410787 (1) (see all 7)
metastatic melanoma	41.9	1	10711641 (1)
htlv-i infections	41.8	1	1982452 (1)
rheumatoid arthritis	41.4	15	2289327 (2), 7738942 (2), 8039284 (2), 7921769 (1) (see all 12)

Genetic Association Database (GAD): IL2RB
Human Genome Epidemiology (HuGE) Navigator: IL2RB (39 documents)

Export disorders for IL2RB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL2RB gene, integrated from 9 sources (see all 1209):
(articles sorted by number of sources associating them with IL2RB)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. (PubMed id 16477002)^{1, 2, 7} Stauber D.J.... Wilson I.A. (2006)
IL-2 receptor signaling through the Shb adapter protein in T and NK cells. (PubMed id 12200137)^{1, 2, 9} Lindholm C.K. (2002)
The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface. (PubMed id 8648694)^{1, 2, 9} Mulloy J.C.... Franchini G. (1996)
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. (PubMed id 16293754)^{1, 2} Wang X.... Garcia K.C. (2005)
Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PubMed id 16380905)^{1, 4} Fallin M.D....Pulver A.E. (2005)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10. (PubMed id 15191519)^{1, 4} Moreno M....Arcos-Burgos M. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3560	HGNC: 6009	AceView: IL2RBandC1QTNF6	Ensembl:ENSG00000100385	euGenes: HUgn3560
ECgene: IL2RB	Kegg: 3560	H-InvDB: IL2RB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL2RB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL2RB	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/il2rb/

Intellectual Property for IL2RB gene
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Patent Information for IL2RB gene:
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GeneCards and IP:
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interleukin 2 receptor, beta

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IL2RB Gene

interleukin 2 receptor, beta

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