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Aliases for IL2RA Gene

Aliases for IL2RA Gene

  • Interleukin 2 Receptor, Alpha 2 3
  • IL-2 Receptor Subunit Alpha 3 4
  • IL-2R Subunit Alpha 3 4
  • TAC Antigen 3 4
  • IDDM10 3 6
  • IL2R 3 6
  • P55 3 4
  • Insulin-Dependent Diabetes Mellitus 10 2
  • Interleukin-2 Receptor Subunit Alpha 3
  • CD25 Antigen 4
  • IL-2-RA 4
  • IL2-RA 4
  • TCGFR 3
  • CD25 3

External Ids for IL2RA Gene

Previous Symbols for IL2RA Gene

  • IL2R
  • IDDM10

Summaries for IL2RA Gene

Entrez Gene Summary for IL2RA Gene

  • The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

GeneCards Summary for IL2RA Gene

IL2RA (Interleukin 2 Receptor, Alpha) is a Protein Coding gene. Diseases associated with IL2RA include interleukin-2 receptor, alpha chain, deficiency of and diabetes, mellitus, insulin-dependent 10. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include drug binding and interleukin-2 binding.

UniProtKB/Swiss-Prot for IL2RA Gene

  • Receptor for interleukin-2

Tocris Summary for IL2RA Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL2RA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL2RA Gene

Genomics for IL2RA Gene

Genomic Location for IL2RA Gene

Start:
6,010,689 bp from pter
End:
6,062,370 bp from pter
Size:
51,682 bases
Orientation:
Minus strand

Genomic View for IL2RA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL2RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL2RA Gene

Regulatory Elements for IL2RA Gene

Proteins for IL2RA Gene

  • Protein details for IL2RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01589-IL2RA_HUMAN
    Recommended name:
    Interleukin-2 receptor subunit alpha
    Protein Accession:
    P01589
    Secondary Accessions:
    • Q5W007

    Protein attributes for IL2RA Gene

    Size:
    272 amino acids
    Molecular mass:
    30819 Da
    Quaternary structure:
    • Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

    Three dimensional structures from OCA and Proteopedia for IL2RA Gene

neXtProt entry for IL2RA Gene

Proteomics data for IL2RA Gene at MOPED

Post-translational modifications for IL2RA Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237

Other Protein References for IL2RA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IL2RA Gene

Domains for IL2RA Gene

Gene Families for IL2RA Gene

HGNC:
  • CD :CD molecules
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL2RA Gene

Suggested Antigen Peptide Sequences for IL2RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01589

UniProtKB/Swiss-Prot:

IL2RA_HUMAN
Domain:
  • Contains 2 Sushi (CCP/SCR) domains.:
    • P01589
genes like me logo Genes that share domains with IL2RA: view

Function for IL2RA Gene

Molecular function for IL2RA Gene

GENATLAS Biochemistry: interleukin 2,low affinity receptor,alpha chain 45kDa,expressed in T cell,B lymphoblast lines,peripheral blood monocyte
UniProtKB/Swiss-Prot Function: Receptor for interleukin-2

Gene Ontology (GO) - Molecular Function for IL2RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004911 interleukin-2 receptor activity IEA --
GO:0005515 protein binding --
GO:0008144 drug binding IEA --
GO:0019976 interleukin-2 binding IBA --
genes like me logo Genes that share ontologies with IL2RA: view
genes like me logo Genes that share phenotypes with IL2RA: view

Animal Models for IL2RA Gene

MGI Knock Outs for IL2RA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL2RA Gene

Localization for IL2RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL2RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL2RA Gene COMPARTMENTS Subcellular localization image for IL2RA gene
Compartment Confidence
plasma membrane 4
extracellular 3
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL2RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL2RA: view

Pathways for IL2RA Gene

genes like me logo Genes that share pathways with IL2RA: view

Gene Ontology (GO) - Biological Process for IL2RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0006915 apoptotic process TAS 9096364
GO:0006924 activation-induced cell death of T cells IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS 9096364
genes like me logo Genes that share ontologies with IL2RA: view

Compounds for IL2RA Gene

(5) Tocris Compounds for IL2RA Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines [6501-72-0]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(4) Drugbank Compounds for IL2RA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aldesleukin
  • IL-2
85898-30-2 target agonist modulator
Basiliximab
  • chimeric mouse-human antiCD25
152923-56-3 target antibody
Daclizumab
  • Anti-IL-2
152923-56-3 target antibody
Denileukin diftitox
  • Diphtheria toxin precursor
173146-27-5 target binder

(142) Novoseek inferred chemical compound relationships for IL2RA Gene

Compound -log(P) Hits PubMed IDs
daclizumab 86.2 77
basiliximab 85.7 82
neopterin 81 140
okt3 72 23
cyclosporin a 69 75

(1) PharmGKB related drug/compound annotations for IL2RA Gene

Drug/compound Annotation
denileukin diftitox
genes like me logo Genes that share compounds with IL2RA: view

Transcripts for IL2RA Gene

Unigene Clusters for IL2RA Gene

Interleukin 2 receptor, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL2RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for IL2RA Gene

GeneLoc Exon Structure for
IL2RA
ECgene alternative splicing isoforms for
IL2RA

Expression for IL2RA Gene

mRNA expression in normal human tissues for IL2RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL2RA Gene

This gene is overexpressed in Spleen (9.3), Small Intestine - Terminal Ileum (6.2), and Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL2RA Gene

SOURCE GeneReport for Unigene cluster for IL2RA Gene Hs.231367

genes like me logo Genes that share expressions with IL2RA: view

No data available for mRNA Expression by UniProt/SwissProt for IL2RA Gene

Orthologs for IL2RA Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL2RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL2RA 35
  • 98.49 (n)
  • 97.74 (a)
IL2RA 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL2RA 35
  • 70.26 (n)
  • 55.39 (a)
IL2RA 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL2RA 35
  • 74.4 (n)
  • 63.88 (a)
IL2RA 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il2ra 35
  • 72.16 (n)
  • 61.42 (a)
Il2ra 16
Il2ra 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL2RA 36
  • 30 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il2ra 35
  • 71.54 (n)
  • 61.8 (a)
Species with no ortholog for IL2RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL2RA Gene

ENSEMBL:
Gene Tree for IL2RA (if available)
TreeFam:
Gene Tree for IL2RA (if available)

Paralogs for IL2RA Gene

Selected SIMAP similar genes for IL2RA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IL2RA: view

No data available for Paralogs for IL2RA Gene

Variants for IL2RA Gene

Sequence variations from dbSNP and Humsavar for IL2RA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs706778 -- 6,056,986(-) CATCA(A/G)TGACA intron-variant
rs706779 -- 6,056,861(-) CTCAA(A/G)CAATG intron-variant
rs706780 -- 6,045,063(+) CGGGA(A/C)AGGAG intron-variant
rs706781 -- 6,044,422(+) TTACA(C/T)GCAGT intron-variant
rs765060 -- 6,039,972(+) AGGCA(C/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL2RA Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV Loss 18971310
nsv525927 CNV Loss 19592680
esv2731873 CNV Deletion 23290073
esv5272 CNV Deletion 18987735
esv1000739 CNV Deletion 20482838
esv2731884 CNV Deletion 23290073
nsv894813 CNV Loss 21882294
nsv894814 CNV Gain 21882294
esv2516054 CNV Deletion 19546169
esv2014648 CNV Deletion 18987734
esv4965 CNV Deletion 18987735
esv2731895 CNV Deletion 23290073
esv1011098 CNV Deletion 20482838
esv9342 CNV Loss 19470904
esv1592945 CNV Deletion 17803354

Relevant External Links for IL2RA Gene

HapMap Linkage Disequilibrium report
IL2RA
Human Gene Mutation Database (HGMD)
IL2RA
Locus Specific Mutation Databases (LSDB)
IL2RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL2RA Gene

Disorders for IL2RA Gene

(2) OMIM Diseases for IL2RA Gene (147730)

UniProtKB/Swiss-Prot

IL2RA_HUMAN
  • Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:17676041}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(94) Novoseek inferred disease relationships for IL2RA Gene

Disease -log(P) Hits PubMed IDs
necrosis 68.4 128
leukemia t-cell 61.9 16
leukemia hairy cell 61.2 9
severe combined immunodeficiency, x-linked 58.9 7
lymphoma t-cell cutaneous 57 15

Genatlas disease for IL2RA Gene

immunodeficiency,severe combined with absence of CD1 and of IL2RA expression on cortical thymocyte

Relevant External Links for IL2RA

Genetic Association Database (GAD)
IL2RA
Human Genome Epidemiology (HuGE) Navigator
IL2RA
genes like me logo Genes that share disorders with IL2RA: view

Publications for IL2RA Gene

  1. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. (PMID: 17676041) Lowe C.E. … Todd J.A. (Nat. Genet. 2007) 2 3 4 48
  2. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. (PMID: 17371467) Brand O.J. … Gough S.C. (Clin. Endocrinol. (Oxf) 2007) 3 23 48
  3. Risk alleles for multiple sclerosis identified by a genomewide study. (PMID: 17660530) . … Hauser S.L. (N. Engl. J. Med. 2007) 3 23 48
  4. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). (PMID: 19125193) Alcina A. … Matesanz F. (PLoS ONE 2009) 3 23 48
  5. Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. (PMID: 19106270) Kawasaki E. … Eguchi K. (J. Clin. Endocrinol. Metab. 2009) 3 23 48

Products for IL2RA Gene

  • Addgene plasmids for IL2RA

Sources for IL2RA Gene

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