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IL2RA Gene

protein-coding   GIFtS: 71
GCID: GC10M006041

Interleukin 2 Receptor, Alpha

(Previous name: insulin-dependent diabetes mellitus 10)
(Previous symbols: IL2R, IDDM10)
  See IL2RA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 2 Receptor, Alpha1 2     IL-2R Subunit Alpha2 3
IDDM101 2 5     p552 3
IL2R1 2 5     TAC Antigen2 3
Insulin-Dependent Diabetes Mellitus 101 2     CD252
IL-2-RA2 3     TCGFR2
IL2-RA2 3     Interleukin-2 Receptor Subunit Alpha2
IL-2 Receptor Subunit Alpha2 3     CD25 Antigen3

External Ids:    HGNC: 60081   Entrez Gene: 35592   Ensembl: ENSG000001344607   OMIM: 1477305   UniProtKB: P015893   

Export aliases for IL2RA gene to outside databases

Previous GC identifers: GC10M005997 GC10M006203 GC10M006058 GC10M006059 GC10M006093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL2RA Gene:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain
(IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity
receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane
protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis.
Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations
in this gene are associated with interleukin 2 receptor alpha deficiency.(provided by RefSeq, Nov 2009)

GeneCards Summary for IL2RA Gene:
IL2RA (interleukin 2 receptor, alpha) is a protein-coding gene. Diseases associated with IL2RA include uveitis, and graft versus host disease. GO annotations related to this gene include drug binding and interleukin-2 binding.

UniProtKB/Swiss-Prot: IL2RA_HUMAN, P01589
Function: Receptor for interleukin-2

summary for IL2RA Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL2RA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL2RA gene promoter:
         STAT1   p53   STAT6   IRF-7A   STAT3   STAT5A   NF-kappaB   NF-kappaB1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL2RA promoter sequence
   Search Chromatin IP Primers for IL2RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL2RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15-p14

IL2RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL2RA gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M006041:  view genomic region     (about GC identifiers)

Start:
6,052,652 bp from pter      End:
6,104,333 bp from pter
Size:
51,682 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL2RA_HUMAN, P01589 (See protein sequence)
Recommended Name: Interleukin-2 receptor subunit alpha precursor  
Size: 272 amino acids; 30819 Da
Subunit: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity
dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and
intermediate affinity forms also associate with a gamma subunit
Selected PDB 3D structures from and Proteopedia for IL2RA (see all 7):
1ILM (3D)        1ILN (3D)        1Z92 (3D)        2B5I (3D)        2ERJ (3D)        3IU3 (3D)    
Secondary accessions: Q5W007

Explore the universe of human proteins at neXtProt for IL2RA: NX_P01589

Explore proteomics data for IL2RA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn70, Asn89, Thr218, Thr224, Thr229, Thr237
  • Modification sites at PhosphoSitePlus

  • See IL2RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000408.1  
    ENSEMBL proteins: 
     ENSP00000369293   ENSP00000369287   ENSP00000256876   ENSP00000402024  
    Reactome Protein details: P01589

    IL2RA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL2RA (IL-2 R alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL2RA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL2RA
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    Novus Biologicals IL2RA Proteins
    Sino Biological Recombinant Protein for IL2RA
    Sino Biological Cell Lysate for IL2RA
    ProSpec Recombinant Protein for IL2RA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IL2RA 

     
    antibodies-online proteins for IL2RA (35 products) 

     
    Search antibodies-online for peptides for IL2RA

    IL2RA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL2RA
    R&D Systems Antibodies for IL2RA (IL-2 R alpha)
    Cell Signaling Technology (CST) Antibodies for IL2RA 
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    OriGene Custom Antibody Services for IL2RA
    Novus Biologicals IL2RA Antibodies
    Abcam antibodies for IL2RA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IL2RA
    antibodies-online antibodies for IL2RA (521 products) 

    IL2RA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL2RA
    R&D Systems ELISAs for IL2RA (IL-2 R alpha)         (see all)
    GenScript Custom Assay Services for IL2RA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for IL2RA: (see all 4
                        Human sIL-2R Platinum ELISA 96 tests
    antibodies-online kits for IL2RA (44 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-2 receptor alpha subunit
    IL-2 receptor family

    2 InterPro protein domains:
     IPR015486 IL-2_rcpt_alpha
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P01589

    ProtoNet protein and cluster: P01589

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: IL2RA_HUMAN, P01589
    Similarity: Contains 2 Sushi (CCP/SCR) domains


    Find genes that share domains with IL2RA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL2RA_HUMAN, P01589
    Function: Receptor for interleukin-2

         Genatlas biochemistry entry for IL2RA:
    interleukin 2,low affinity receptor,alpha chain 45kDa,expressed in T cell,B lymphoblast lines,peripheral blood
    monocyte

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004911interleukin-2 receptor activity IEA--
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--
    GO:0019976interleukin-2 binding IEA--
         
    Find genes that share ontologies with IL2RA           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for IL2RA:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased cell death in breast 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il2ra):
     digestive/alimentary  growth/size/body  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with IL2RA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il2ratm1Dw for IL2RA

       genOway: Develop your customized and physiologically relevant rodent model for IL2RA

    miRNA
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    Block miRNA regulation of human, mouse, rat IL2RA using miScript Target Protectors
    11 qRT-PCR Assays for microRNAs that regulate IL2RA (see first 8):
    hsa-miR-30c hsa-miR-875-3p hsa-miR-520f hsa-miR-186* hsa-miR-30d hsa-miR-3667-3p hsa-miR-30a hsa-miR-30b
    hsa-miR-520g hsa-miR-1299 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidIL2RA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL2RA
    Predesigned siRNA for gene silencing in human, mouse, rat IL2RA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL2RA

    Clone
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: IL2RA (NM_000417)
    Sino Biological Human cDNA Clone for IL2RA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL2RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2RA
    Addgene plasmids for IL2RA 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL2RA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL2RA_HUMAN, P01589: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    nucleus2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    endosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL2RA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL2RA About   (see all 40)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    NFAT Signaling and Lymphocyte Interactions0.57
    Glucocorticoid Receptor Signaling0.43
    PGC1Alpha Pathway0.51
    Cytokine-cytokine receptor interaction0.43
    STAT3 Pathway0.47
    2IL2-mediated signaling events
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    PPAR Pathway0.66
    Cellular Apoptosis Pathway0.85
    Rac1 Pathway0.65
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    5Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42


    Find genes that share SuperPaths with IL2RA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IL2RA
        IL-2 Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL2RA (see all 38)
        Nuclear Receptor Activation by Vitamin-A
    THC Differentiation Pathway
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for IL2RA
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    3 Tocris Bioscience Pathways for IL2RA
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    3 GeneGo (Thomson Reuters) Pathways for IL2RA
        Immune response IL-12 signaling pathway
    Immune response IL-22 signaling pathway
    Immune response IL-2 activation and signaling pathway

    Selected BioSystems Pathways for IL2RA (see all 12)
        IL-2 Signaling pathway
    TSLP Signaling Pathway
    Calcium signaling in the CD4+ TCR pathway
    IL2 signaling events mediated by PI3K
    IL2-mediated signaling events


    2 Reactome Pathways for IL2RA
        Interleukin receptor SHC signaling
    Interleukin-2 signaling


    Selected Kegg Pathways  (Kegg details for IL2RA) (see all 7):
        Cytokine-cytokine receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2RA (see all 14): 
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL2RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL2RA (P015892, 3 ENSP000003692934) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PASKQ96RG22, 3, ENSP000002340404MINT-8148865 I2D: score=1 STRING: ENSP00000234040
    IL2P605683, ENSP000002267304I2D: score=4 STRING: ENSP00000226730
    ICAM1P053623, ENSP000002648324I2D: score=3 STRING: ENSP00000264832
    IL2RBP147843, ENSP000002162234I2D: score=3 STRING: ENSP00000216223
    NFKB1P198383, ENSP000002265744I2D: score=2 STRING: ENSP00000226574
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    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002437inflammatory response to antigenic stimulus IEA--
    GO:0006915apoptotic process TAS9096364
    GO:0006924activation-induced cell death of T cells IEA--
    GO:0006955immune response TAS9096364
    GO:0007166cell surface receptor signaling pathway TAS2983318

    Find genes that share ontologies with IL2RA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for IL2RA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    4 DrugBank Compounds for IL2RA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AldesleukinIL-2 (see all 4)85898-30-2targetagonist modulator16767920 16864089 11752352 17530023 17216565 17584597 10207608
    DaclizumabAnti-IL-2 (see all 3)152923-56-3targetantibody17564638 19788505 8600944 16304857 11752352 16908318 10607689
    Denileukin diftitoxDiphtheria toxin precursor (see all 3)173146-27-5targetbinder17139284 2786749 3124610 11752352 17187516 17016423 18684057
    Basiliximabchimeric mouse-human antiCD25 (see all 2)152923-56-3targetantibody10567956 12591363 11752352 16908318 10512062 9695721

    Selected Novoseek inferred chemical compound relationships for IL2RA gene (see all 142)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    daclizumab 86.2 101 11147695 (5), 15919507 (3), 10607689 (2), 9428817 (2) (see all 60)
    basiliximab 85.7 113 12727469 (6), 17440057 (5), 10573065 (4), 15848561 (3) (see all 60)
    neopterin 81 151 15756710 (6), 8260527 (6), 1444001 (5), 8258242 (3) (see all 97)
    okt3 72 30 1858157 (2), 1969884 (2), 1832993 (1), 15591961 (1) (see all 21)
    cyclosporin a 69 97 1864013 (4), 7702403 (3), 1346344 (2), 1812996 (2) (see all 63)
    denileukin diftitox 66.8 15 12149223 (2), 15811959 (2), 14506141 (1), 15744237 (1) (see all 9)
    ionomycin 62.6 33 8557519 (3), 2017664 (3), 2320954 (3), 2315321 (2) (see all 21)
    tacrolimus 62.3 45 8557519 (2), 15162466 (2), 7678231 (1), 9346613 (1) (see all 34)
    mycophenolate mofetil 62 29 20405579 (2), 16980068 (2), 10563181 (1), 10578712 (1) (see all 18)
    thymidine 56.2 52 2382107 (2), 1974593 (2), 9329587 (2), 11904739 (2) (see all 41)

    1 PharmGKB related drug/compound annotation for IL2RA gene    About this table
    Drug/compound PharmGKB Annotation
    denileukin diftitox



    Find genes that share compounds with IL2RA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL2RA gene: 
    NM_000417.2  

    Unigene Cluster for IL2RA:

    Interleukin 2 receptor, alpha
    Hs.231367  [show with all ESTs]
    Unigene Representative Sequence: NM_000417
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379959(uc001iiz.2 uc009xih.2) ENST00000379954 ENST00000256876(uc001ija.1)
    ENST00000447847
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IL2RA (see all 11):
    hsa-miR-30c hsa-miR-875-3p hsa-miR-520f hsa-miR-186* hsa-miR-30d hsa-miR-3667-3p hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidIL2RA 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: IL2RA (NM_000417)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2RA
    Addgene plasmids for IL2RA 
    Primer
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    OriGene qPCR primer pairs and template standards for IL2RA
    OriGene qSTAR qPCR primer pairs in human, mouse for IL2RA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL2RA
      QuantiTect SYBR Green Assays in human, mouse, rat IL2RA
      QuantiFast Probe-based Assays in human, mouse, rat IL2RA

    Additional mRNA sequence: 

    AF008556.1 AK223313.1 AK313847.1 K03122.1 M14098.1 X01057.1 

    3 DOTS entries:

    DT.451929  DT.40128074  DT.121287686 

    Selected AceView cDNA sequences (see all 42):

    BM922713 AA641972 BP367522 BQ574113 AW950881 T28947 AI418535 BG232109 
    NM_000417 AF008556 BG057703 CD365812 AW444951 BG536515 CD701954 M14098 
    CB529386 BQ774288 AA903496 BF907985 K03122 BF439973 X01057 CD366300 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL2RA    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                          -                                                               
    SP2:                          -                 -     -                                       
    SP3:                          -                 -     -     -                                 
    SP4:                          -                       -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for IL2RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL2RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL2RA Expression
    About this image


    IL2RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 14 entries
             T-Regulatory Cells Peripheral Blood
             Regulatory T cells
             cd4+ cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 5 entries
             Double Negative 3 Thymocytes Thymus
     
     Endothelium (Cardiovascular System)
             cd31+ cells   
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Prostate (Endocrine System)
    IL2RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL2RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.231367
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2RA (see all 14): 
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL2RA gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il2ra1 , 5 interleukin 2 receptor, alpha chain1, 5 72.16(n)1
    61.42(a)1
      2 (8.91 cM)5
    161841  NM_008367.31  NP_032393.31 
     116427925 


    ENSEMBL Gene Tree for IL2RA (if available)
    TreeFam Gene Tree for IL2RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL2RA gene
    1 SIMAP similar gene for IL2RA using alignment to 4 protein entries:     IL2RA_HUMAN (see all proteins):
    IL2R

    Find genes that share paralogs with IL2RA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL2RA (see all 1360)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166734671,2
    F--5978993(+) TGATTC/TGCATT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs127226101,2
    C,F--5979005(-) GGTCAT/CTTCAG 1 -- ds50014Minor allele frequency- C:0.09NS NA 204
    rs1930336901,2
    --5979149(+) TGGGTA/GGATCA 1 -- ds50010--------
    rs1459463251,2
    C--5979158(+) CACTTA/GAGGTG 1 -- ds50010--------
    rs1857272031,2
    --5979236(+) GGACTG/TGGTGG 1 -- ds50010--------
    rs1898024011,2
    C--5979270(+) TTGGGA/TGGCTG 1 -- ds50010--------
    rs1461629891,2
    C--5979387(+) AAAAA-/CAAAAA 1 -- ds50010--------
    rs1173549301,2
    F--5979406(+) AAAAGC/TACCAA 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs127226091,2
    C,F--5979477(-) CTTGGT/GTTTTA 1 -- ds50017Minor allele frequency- G:0.17NS NA WA CSA 334
    rs748952461,2
    C,F--5979560(+) ATGACA/CTCATC 1 -- ut311Minor allele frequency- C:0.04EA 120

    HapMap Linkage Disequilibrium report for IL2RA (6052652 - 6104333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IL2RA (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2014648CNV Deletion18987734
    esv1011098CNV Deletion20482838
    esv2731873CNV Deletion23290073
    esv2731884CNV Deletion23290073
    esv1000739CNV Deletion20482838
    esv2731895CNV Deletion23290073
    esv5272CNV Deletion18987735
    esv2516054CNV Deletion19546169
    esv1592945CNV Deletion17803354
    esv4965CNV Deletion18987735

    Human Gene Mutation Database (HGMD): IL2RA
    Locus Specific Mutation Databases (LSDB): IL2RA

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL2RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL2RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147730   
    OMIM disorders: 606367  601942  
    UniProtKB/Swiss-Prot: IL2RA_HUMAN, P01589
  • Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose
    homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical
    features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and
    secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and
    blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this
    entry

  • Selected diseases for IL2RA (see all 43):    
    About MalaCards
    uveitis    graft versus host disease    interleukin 2 receptor alpha chain deficiency    small non-cleaved cell lymphoma
    diabetes, mellitus, insulin-dependent 10    cervicitis    farmer's lung    eosinophilic colitis
    pleurisy    oligoarticular juvenile arthritis    intermediate uveitis    polyarticular onset juvenile idiopathic arthritis
    vogt-koyanagi-harada disease    urticaria pigmentosa    cutaneous t cell lymphoma    macrophage activation syndrome
    pure red-cell aplasia    mastocytosis    t-cell large granular lymphocyte leukemia    large granular lymphocyte leukemia

    11 diseases from the University of Copenhagen DISEASES database for IL2RA:
    Lymphoma     Leukemia     Hypersensitivity reaction type II disease     Hemophagocytic lymphohistiocytosis
    Sarcoidosis     Rheumatoid arthritis     Connective tissue disease     Skin disease
    Multiple sclerosis     Tuberculosis     Severe combined immunodeficiency

    Find genes that share disorders with IL2RA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL2RA gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 68.4 370 1747228 (3), 8651123 (3), 11505128 (2), 12745543 (2) (see all 99)
    leukemia t-cell 61.9 17 2196176 (1), 1916630 (1), 1719236 (1), 8170951 (1) (see all 16)
    leukemia hairy cell 61.2 11 8329708 (2), 1394125 (2), 8289505 (1), 7820050 (1) (see all 7)
    severe combined immunodeficiency, x-linked 58.9 8 9371254 (1), 7937790 (1), 7907259 (1), 8998263 (1) (see all 7)
    lymphoma t-cell cutaneous 57 16 16830050 (1), 1728640 (1), 8490933 (1), 9486676 (1) (see all 15)
    htlv-i infections 56.5 1 7668218 (1)
    rheumatoid arthritis 55.3 76 2313471 (2), 2118434 (2), 2075380 (2), 8311539 (2) (see all 53)
    autoimmune diseases 54.8 38 7473471 (3), 15843513 (2), 7875652 (1), 8691563 (1) (see all 24)
    tumors 54.3 435 15328201 (4), 1535088 (3), 1747228 (3), 8651123 (3) (see all 99)
    lymphohistiocytosis hemophagocytic 53.9 4 19576122 (1), 15863596 (1), 20511152 (1), 8541568 (1)

    Genatlas disease: IL2RA
    immunodeficiency,severe combined with absence of CD1 and of IL2RA expression on cortical thymocyte

    Genetic Association Database (GAD): IL2RA
    Human Genome Epidemiology (HuGE) Navigator: IL2RA (82 documents)

    Export disorders for IL2RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL2RA gene, integrated from 10 sources (see all 2533):
    (articles sorted by number of sources associating them with IL2RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. (PubMed id 17676041)1, 2, 3, 4 Lowe C.E.... Todd J.A. (Nat. Genet. 2007)
    2. Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. (PubMed id 19106270)1, 4, 9 Kawasaki E....Eguchi K. (J. Clin. Endocrinol. Metab. 2009)
    3. Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients. (PubMed id 19231135)1, 4, 9 Akkad D.A....Epplen J.T. (J. Autoimmun. 2009)
    4. Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. (PubMed id 19116909)1, 4, 9 Hinks A.... . (Arthritis Rheum. 2009)
    5. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). (PubMed id 19125193)1, 4, 9 Alcina A....Matesanz F. (PLoS ONE 2009)
    6. Risk alleles for multiple sclerosis identified by a genomewide study. (PubMed id 17660530)1, 4, 9  ....Hauser S.L. (N. Engl. J. Med. 2007)
    7. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. (PubMed id 17371467)1, 4, 9 Brand O.J....Gough S.C. (Clin. Endocrinol. (Oxf) 2007)
    8. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. (PubMed id 15776395)1, 4, 9 Vella A....Todd J.A. (Am. J. Hum. Genet. 2005)
    9. 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. (PubMed id 22293688)1, 4 Huang J....Li Y. (Eur. J. Hum. Genet. 2012)
    10. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PubMed id 22228203)1, 4 Aslibekyan S....Arnett D.K. (Pharmacogenet. Genomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3559 HGNC: 6008 AceView: IL2RA Ensembl:ENSG00000134460 euGenes: HUgn3559
    ECgene: IL2RA Kegg: 3559 H-InvDB: IL2RA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL2RA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL2RA Genetics and Cytogenetics in Oncology and Haematology
    IL2RAbasehttp://bioinf.uta.fi/IL2RAbase/
    SeattleSNPshttp://pga.gs.washington.edu/data/il2ra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL2RA gene:
    Search GeneIP for patents involving IL2RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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