Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL2RA Gene

Aliases for IL2RA Gene

  • Interleukin 2 Receptor Subunit Alpha 2 3 5
  • Interleukin 2 Receptor, Alpha 2 3
  • IL-2 Receptor Subunit Alpha 3 4
  • IL-2R Subunit Alpha 3 4
  • TAC Antigen 3 4
  • P55 3 4
  • Insulin-Dependent Diabetes Mellitus 10 2
  • CD25 Antigen 4
  • IL-2-RA 4
  • IDDM10 3
  • IL2-RA 4
  • IMD41 3
  • TCGFR 3
  • CD25 3
  • IL2R 3

External Ids for IL2RA Gene

Previous HGNC Symbols for IL2RA Gene

  • IL2R
  • IDDM10

Previous GeneCards Identifiers for IL2RA Gene

  • GC10M005997
  • GC10M006203
  • GC10M006058
  • GC10M006059
  • GC10M006093
  • GC10M006041

Summaries for IL2RA Gene

Entrez Gene Summary for IL2RA Gene

  • The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

GeneCards Summary for IL2RA Gene

IL2RA (Interleukin 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL2RA include immunodeficiency 41 with lymphoproliferation and autoimmunity and diabetes, mellitus, insulin-dependent 10. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include drug binding and interleukin-2 binding.

UniProtKB/Swiss-Prot for IL2RA Gene

  • Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T cells.

Tocris Summary for IL2RA Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL2RA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL2RA Gene

Genomics for IL2RA Gene

Regulatory Elements for IL2RA Gene

Promoters for IL2RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL2RA on UCSC Golden Path with GeneCards custom track

Genomic Location for IL2RA Gene

Chromosome:
10
Start:
6,010,689 bp from pter
End:
6,062,370 bp from pter
Size:
51,682 bases
Orientation:
Minus strand

Genomic View for IL2RA Gene

Genes around IL2RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL2RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL2RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL2RA Gene

Proteins for IL2RA Gene

  • Protein details for IL2RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01589-IL2RA_HUMAN
    Recommended name:
    Interleukin-2 receptor subunit alpha
    Protein Accession:
    P01589
    Secondary Accessions:
    • Q5W007

    Protein attributes for IL2RA Gene

    Size:
    272 amino acids
    Molecular mass:
    30819 Da
    Quaternary structure:
    • Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

    Three dimensional structures from OCA and Proteopedia for IL2RA Gene

neXtProt entry for IL2RA Gene

Proteomics data for IL2RA Gene at MOPED

Post-translational modifications for IL2RA Gene

  • Glycosylation at Asn 70, Asn 89, Thr 218, Thr 224, Thr 229, and Thr 237
  • Modification sites at PhosphoSitePlus

Other Protein References for IL2RA Gene

Antibody Products

  • R&D Systems Antibodies for IL2RA (CD25/IL-2 R alpha)
  • Cell Signaling Technology (CST) Antibodies for IL2RA (IL2RA)

No data available for DME Specific Peptides for IL2RA Gene

Domains & Families for IL2RA Gene

Protein Domains for IL2RA Gene

Suggested Antigen Peptide Sequences for IL2RA Gene

Graphical View of Domain Structure for InterPro Entry

P01589

UniProtKB/Swiss-Prot:

IL2RA_HUMAN :
  • Contains 2 Sushi (CCP/SCR) domains.
Domain:
  • Contains 2 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with IL2RA: view

Function for IL2RA Gene

Molecular function for IL2RA Gene

GENATLAS Biochemistry:
interleukin 2,low affinity receptor,alpha chain 45kDa,expressed in T cell,B lymphoblast lines,peripheral blood monocyte
UniProtKB/Swiss-Prot Function:
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T cells.
genes like me logo Genes that share phenotypes with IL2RA: view

Human Phenotype Ontology for IL2RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL2RA Gene

MGI Knock Outs for IL2RA:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL2RA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL2RA
  • R&D Systems cDNA Clones for IL2RA (CD25/IL-2 R alpha)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IL2RA Gene

Localization for IL2RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL2RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL2RA Gene COMPARTMENTS Subcellular localization image for IL2RA gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IL2RA Gene

Pathways & Interactions for IL2RA Gene

SuperPathways for IL2RA Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PEDF Induced Signaling
4 TGF-Beta Pathway
5 Signaling by GPCR
genes like me logo Genes that share pathways with IL2RA: view

SIGNOR curated interactions for IL2RA Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for IL2RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0002664 regulation of T cell tolerance induction IMP 23416241
GO:0006915 apoptotic process TAS 9096364
GO:0006924 activation-induced cell death of T cells IEA --
genes like me logo Genes that share ontologies with IL2RA: view

Drugs & Compounds for IL2RA Gene

(93) Drugs for IL2RA Gene - From: Novoseek, FDA Approved Drugs, DGIdb, DrugBank, PharmGKB, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma antibody, Target 96,129
Denileukin diftitox Approved, Investigational Pharma binder, Target 48
Aldesleukin Approved Pharma inhibitor, modulator, Target, agonist 387
Proleukin Approved January 1998 Pharma 0
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 808

(60) Additional Compounds for IL2RA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
10Z-Hymenialdisine
82005-12-7
Chicago Sky Blue 6B
2610-05-1

(5) Tocris Compounds for IL2RA Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
Chicago Sky Blue 6B Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF 2610-05-1
Gabexate mesylate Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin 56974-61-9
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1

(1) ApexBio Compounds for IL2RA Gene

Compound Action Cas Number
Dexamethasone Sodium Phosphate 55203-24-2
genes like me logo Genes that share compounds with IL2RA: view

Transcripts for IL2RA Gene

Unigene Clusters for IL2RA Gene

Interleukin 2 receptor, alpha:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL2RA
  • R&D Systems cDNA Clones for IL2RA (CD25/IL-2 R alpha)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL2RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:

Relevant External Links for IL2RA Gene

GeneLoc Exon Structure for
IL2RA
ECgene alternative splicing isoforms for
IL2RA

Expression for IL2RA Gene

mRNA expression in normal human tissues for IL2RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL2RA Gene

This gene is overexpressed in Spleen (x9.3), Small Intestine - Terminal Ileum (x6.2), and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for IL2RA Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL2RA Gene



SOURCE GeneReport for Unigene cluster for IL2RA Gene Hs.231367

genes like me logo Genes that share expression patterns with IL2RA: view

Protein tissue co-expression partners for IL2RA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL2RA Gene

Orthologs for IL2RA Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL2RA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL2RA 35
  • 70.26 (n)
  • 55.39 (a)
IL2RA 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL2RA 35
  • 74.4 (n)
  • 63.88 (a)
IL2RA 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il2ra 35
  • 72.16 (n)
  • 61.42 (a)
Il2ra 16
Il2ra 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL2RA 35
  • 98.49 (n)
  • 97.74 (a)
IL2RA 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il2ra 35
  • 71.54 (n)
  • 61.8 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia IL2RA 36
  • 30 (a)
OneToOne
Species with no ortholog for IL2RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL2RA Gene

ENSEMBL:
Gene Tree for IL2RA (if available)
TreeFam:
Gene Tree for IL2RA (if available)

Paralogs for IL2RA Gene

(1) SIMAP similar genes for IL2RA Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IL2RA: view

No data available for Paralogs for IL2RA Gene

Variants for IL2RA Gene

Sequence variations from dbSNP and Humsavar for IL2RA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12722712 - 6,012,876(-) AACAA(C/T)CTAGA reference, missense
VAR_074641 Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)
VAR_074642 Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)
rs809356 -- 6,049,185(+) ggggc(C/T)ctgct intron-variant
rs765060 -- 6,039,972(+) AGGCA(C/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL2RA Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV Loss 18971310
nsv525927 CNV Loss 19592680
esv2731873 CNV Deletion 23290073
esv5272 CNV Deletion 18987735
esv1000739 CNV Deletion 20482838
esv2731884 CNV Deletion 23290073
nsv894813 CNV Loss 21882294
nsv894814 CNV Gain 21882294
esv2516054 CNV Deletion 19546169
esv2014648 CNV Deletion 18987734
esv4965 CNV Deletion 18987735
esv2731895 CNV Deletion 23290073
esv1011098 CNV Deletion 20482838
esv9342 CNV Loss 19470904
esv1592945 CNV Deletion 17803354

Variation tolerance for IL2RA Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL2RA Gene

HapMap Linkage Disequilibrium report
IL2RA
Human Gene Mutation Database (HGMD)
IL2RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL2RA Gene

Disorders for IL2RA Gene

MalaCards: The human disease database

(68) MalaCards diseases for IL2RA Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 41 with lymphoproliferation and autoimmunity
  • cd25 deficiency
diabetes, mellitus, insulin-dependent 10
  • diabetes, mellitus, insulin-dependent, susceptibility to, 10
immunodeficiency due to cd25 deficiency
  • interleukin-2 receptor alpha chain deficiency
interleukin 2 receptor alpha chain deficiency
intermediate uveitis
  • chronic cyclitis
- elite association - COSMIC cancer census association via MalaCards
Search IL2RA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL2RA_HUMAN
  • Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:17676041}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41) [MIM:606367]: A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions. {ECO:0000269 PubMed:23416241, ECO:0000269 PubMed:24116927}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for IL2RA Gene

immunodeficiency,severe combined with absence of CD1 and of IL2RA expression on cortical thymocyte

Relevant External Links for IL2RA

Genetic Association Database (GAD)
IL2RA
Human Genome Epidemiology (HuGE) Navigator
IL2RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL2RA
genes like me logo Genes that share disorders with IL2RA: view

Publications for IL2RA Gene

  1. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. (PMID: 17676041) Lowe C.E. … Todd J.A. (Nat. Genet. 2007) 2 3 4 48 67
  2. Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. (PMID: 19106270) Kawasaki E. … Eguchi K. (J. Clin. Endocrinol. Metab. 2009) 3 23
  3. Serum soluble interleukin-2 receptor levels in patients with malignant lymphoma of bone. (PMID: 19499289) Akahane T. … Kato H. (J Orthop Sci 2009) 3 23
  4. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. (PMID: 19119414) Maier L.M. … Hafler D.A. (PLoS Genet. 2009) 3 23
  5. Disengaging the IL-2 receptor with daclizumab enhances IL-7-mediated proliferation of CD4(+) and CD8(+) T cells. (PMID: 19788505) Monti P. … Bonifacio E. (Am. J. Transplant. 2009) 23 25

Products for IL2RA Gene

Sources for IL2RA Gene

Back to Top

Content