Aliases for IL2RA Gene
External Ids for IL2RA Gene
Previous HGNC Symbols for IL2RA Gene
Previous GeneCards Identifiers for IL2RA Gene
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
GeneCards Summary for IL2RA Gene
IL2RA (Interleukin 2 Receptor, Alpha) is a Protein Coding gene. Diseases associated with IL2RA include interleukin-2 receptor, alpha chain, deficiency of and diabetes, mellitus, insulin-dependent 10. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include drug binding and interleukin-2 binding.
UniProtKB/Swiss-Prot for IL2RA Gene
Receptor for interleukin-2
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.