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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL27RA Gene

protein-coding   GIFtS: 55
GCID: GC19P014142

interleukin 27 receptor, alpha
 Explore 8 diseases affiliated with
IL27RA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL27RA    

Aliases
for IL27RA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 27 Receptor, Alpha1 2     IL-27R Subunit Alpha2 3
TCCR1 2 3 5     IL-27R1
WSX11 2 3 5     WSX-11
CRL11 2 3     IL27R2
Zcytor11     Class I Cytokine Receptor2
Cytokine Receptor-Like 12 3     Interleukin-27 Receptor Subunit Alpha2
Type I T-Cell Cytokine Receptor2 3     T-Cell Cytokine Receptor Type 12
IL-27R-Alpha1     ZcytoR13
IL-27RA2 3     Cytokine Receptor WSX-13
IL-27 Receptor Subunit Alpha2 3     

External Ids:    HGNC: 172901   Entrez Gene: 94662   Ensembl: ENSG000001049987   OMIM: 6053505   UniProtKB: Q6UWB13   

Export aliases for IL27RA gene to outside databases

Previous GC identifers: GC19P014003 GC19P013714


Summaries
for IL27RA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL27RA:
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity,
predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which
are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated
transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein
which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a
glycosylated transmembrane protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling
system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be
involved in innate defense mechanisms

Gene Wiki entry for IL27RA (Interleukin 27 receptor, alpha subunit)


Genomic Views
for IL27RA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL27RA gene promoter:
         SRF   NF-1   NF-1/L   SRF (504 AA)   GATA-1   AREB6   PPAR-gamma1   STAT3   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL27RA promoter sequence
   Search SABiosciences Chromatin IP Primers for IL27RA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL27RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.11

IL27RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL27RA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014142:  view genomic region     (about GC identifiers)

Start:
 14,142,262 bp from pter      End:
 14,164,026 bp from pter
Size:
 21,765 bases      Orientation:
 plus strand

Proteins
for IL27RA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1 (See protein sequence)
Recommended Name: Interleukin-27 receptor subunit alpha precursor  
Size: 636 amino acids; 69474 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A0N0L1 O60624

Explore the universe of human proteins at neXtProt for IL27RA: NX_Q6UWB1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UWB1

    • IL27RA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004834.1  
    ENSEMBL proteins: 
     ENSP00000263379  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL27RA (IL-27 R alpha/WSX-1/TCCR)
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    OriGene Purified Protein: IL27RA
    OriGene Protein Over-expression Lysate: IL27RA
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    Novus Biologicals IL27RA Proteins
    Novus Biologicals IL27RA Lysate
    Sino Biological Recombinant Protein for IL27RA
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9600072


    IL27RA for ontologies           About GeneDecksing



    IL27RA Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for IL27RA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL27RA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6UWB1

    ProtoNet protein and cluster: Q6UWB1

    1 Blocks protein family: IPB003529 Long hematopoietin receptor

    UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 3 fibronectin type-III domains


    Function
    for IL27RA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
    Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling
    system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be
    involved in innate defense mechanisms

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IL27RA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL27RA
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL27RA:
    hsa-miR-3909 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: IL27RA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL27RA (see all 7)
    OriGene shRNA RFP: IL27RA
    OriGene siRNA: IL27RA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL27RA

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL27RA (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL27RA 

    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9600072
    GO:0005515protein binding ----
    GO:0045509interleukin-27 receptor activity IEA--


    IL27RA for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IL27RA:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-outs for IL27RA: Il27ratm1Fjs Il27ratm1Mak
         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Il27ra):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  renal/urinary system  skeleton 

    IL27RA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IL27RA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IL27-mediated signaling events
    		IL27-mediated signaling events1.00
    		Th1 Differentiation0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for IL27RA
        Th1 Differentiation


    1 BioSystems Pathway for IL27RA 
        IL27-mediated signaling events


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL27RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for IL27RA (Q6UWB13 ENSP000002633794) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EBI3Q142133, ENSP000002218474I2D: score=3 STRING: ENSP00000221847
    STAT1P422243, ENSP000003543944I2D: score=3 STRING: ENSP00000354394
    IL27Q8NEV93, ENSP000003493654I2D: score=2 STRING: ENSP00000349365
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    JAK1P234583, ENSP000003432044I2D: score=1 STRING: ENSP00000343204
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002827positive regulation of T-helper 1 type immune response IEA--
    GO:0002829negative regulation of type 2 immune response IEA--
    GO:0006955immune response TAS9600072
    GO:0007166cell surface receptor signaling pathway TAS9600072
    GO:0032729positive regulation of interferon-gamma production IEA--


    IL27RA for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL27RA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL27RA
    Search CenterWatch for drugs/clinical trials and news about IL27RA / I27RA 

    Transcripts
    for IL27RA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL27RA gene: 
    NM_004843.3  

    Unigene Cluster for IL27RA:

    Interleukin 27 receptor, alpha
    Hs.132781  [show with all ESTs]
    Unigene Representative Sequence: NM_004843
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263379(uc002mxx.3)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL27RA:
    hsa-miR-3909 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: IL27RA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL27RA (see all 7)
    OriGene shRNA RFP: IL27RA
    OriGene siRNA: IL27RA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL27RA
    Clone
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    GenScript: all cDNA clones in your preferred vector: IL27RA (NM_004843)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL27RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL27RA 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL27RA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL27RA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL27RA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL27RA

    Additional cDNA sequence: 

    AF053004.1 AF106912.1 AF265242.1 AY358876.1 BC028003.1 

    1 DOTS entry:

    DT.108308 

    24/81 AceView cDNA sequences (see all 81):

    BQ919454 CA426655 AB076563 BU632122 BP337994 BM761233 BM760781 AI347487 
    BM762764 BF829683 AF106912 BM764289 AF447451 BC028003 AI769137 NM_004843 
    NM_080864 BM804052 AW575269 BM761623 AA302915 AY358876 BM844856 BQ927024 

    GeneLoc Exon Structure


    Expression
    for IL27RA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL27RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGCACACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL27RA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primordial germ cell-like cells (Reconstitution of mo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL27RA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL27RA

    SOURCE GeneReport for Unigene cluster: Hs.132781

    UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
    Tissue specificity: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes.
    Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle,
    kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level
    expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL27RA: 
              Th1/Th2 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27RA

    Orthologs
    for IL27RA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL27RA gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia IL27RA6
    		 --
    		 26(a)
    		 1 ↔ 1
    		 2(76778983-76805771)
    zebrafish
    (Danio rerio)    		 Actinopterygii il12rb2l6
    		 interleukin 12 receptor, beta 2a, like
    		 14(a)
    		 1 ↔ 1
    		 3(19038465-19064947)


    ENSEMBL Gene Tree for IL27RA (if available)
    TreeFam Gene Tree for IL27RA (if available) 

    Paralogs
    for IL27RA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL27RA gene
    OSMR2  CSF3R2  IL6ST2  IL31RA2  LIFR2  IL12RB22  

    IL27RA for paralogs           About GeneDecksing



    Genomic Variants
    for IL27RA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/480 NCBI SNPs in IL27RA are shown (see all 480)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs72482691,2
    		C,F,A,H--14140612(+) AGTGAT/CCAATA 2 -- us2k1 int17Minor allele frequency- C:0.12NS NA 610
    rs1405815721,2
    		C,--14140619(+) AATAA-/ATTATTAT 2 -- int1 us2k10--------
    rs104257901,2
    		C,F,--14140662(+) TGAGAC/TAGGGT 2 -- us2k1 int13Minor allele frequency- T:0.33NA WA 6
    rs1856302101,2
    		--14140936(+) GACTCA/TATAGT 2 -- us2k1 int10--------
    rs1903425211,2
    		--14140983(+) TAAGTA/TTTTTT 2 -- us2k1 int10--------
    rs1379530081,2
    		--14141067(+) AACATA/TGAGGC 2 -- us2k1 int10--------
    rs735196311,2
    		C,--14141271(+) GTTTGC/AGACCA 2 -- int1 us2k17Minor allele frequency- A:0.48WA CSA NA EA 365
    rs1424696511,2
    		--14141352(+) GTAATC/GCCACC 2 -- us2k1 int10--------
    rs1807464741,2
    		--14141410(+) ACTCTG/TAACTA 2 -- int1 us2k10--------
    rs745298171,2
    		F,--14141469(+) TGACTG/ATGGGT 2 -- us2k1 int11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for IL27RA (14142262 - 14164026 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IL27RA
         1 CNV: 5089

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL27RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL27RA

    Disorders / Diseases
    for IL27RA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL27RA for disorders           About GeneDecksing

    OMIM gene information: 605350    OMIM disorders: --

    8 diseases for IL27RA:    About MalaCards
    membranous glomerulonephritis    bronchiolitis    glomerulonephritis    encephalomyelitis
    nasopharyngitis    prostatitis    neuronitis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: IL27RA (3 documents)

    Export disorders for IL27RA gene to outside databases

    Publications
    for IL27RA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL27RA gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with IL27RA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. (PubMed id 11057672)1, 2, 3 Chen Q....de Sauvage F.J. (2000)
    2. Cloning and characterization of a novel class I cytokine receptor. (PubMed id 9600072)1, 2, 3 Sprecher C.A.... Foster D.F. (1998)
    3. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. (PubMed id 14764690)1, 2 Pflanz S....Kastelein R.A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Expression of WSX1 in tumors sensitizes IL-27 signali ng-independent natural killer cell surveillance. (PubMed id 19549909)1, 9 Dibra D....Li S. (2009)
    7. Humanin inhibits neuronal cell death by interacting w ith a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX- 1/gp130. (PubMed id 19386761)1, 9 Hashimoto Y....Matsuoka M. (2009)
    8. TCCR/WSX-1 is a novel angiogenic factor in age-related macular degeneration. (PubMed id 22312192)1 Sung H.J....Heo K. (2012)
    9. Mutations in the transmembrane and juxtamembrane doma ins enhance IL27R transforming activity. (PubMed id 21631431)1 Lambert Q.T....Reuther G.W. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for IL27RA gene

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    Genome Databases showing IL27RA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9466 HGNC: 17290 AceView: IL27RAandRLN3 Ensembl:ENSG00000104998 euGenes: HUgn9466
    ECgene: IL27RA H-InvDB: IL27RA

    Other Databases showing IL27RA gene

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    Specialized Databases showing IL27RA gene

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    PharmGKB entry for IL27RA Pharmacogenomics, SNPs, Pathways

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