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Aliases for IL27RA Gene

Aliases for IL27RA Gene

  • Interleukin 27 Receptor, Alpha 2 3
  • TCCR 3 4 6
  • WSX1 3 4 6
  • T-Cell Cytokine Receptor Type 1 2 3
  • Type I T-Cell Cytokine Receptor 3 4
  • IL-27 Receptor Subunit Alpha 3 4
  • Cytokine Receptor-Like 1 3 4
  • Cytokine Receptor WSX-1 3 4
  • IL-27R Subunit Alpha 3 4
  • IL-27R-Alpha 3 4
  • Zcytor1 3 4
  • IL-27RA 3 4
  • CRL1 3 4
  • Interleukin-27 Receptor Subunit Alpha 3
  • Class I Cytokine Receptor 3
  • IL27R 3

External Ids for IL27RA Gene

Summaries for IL27RA Gene

Entrez Gene Summary for IL27RA Gene

  • In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL27RA Gene

IL27RA (Interleukin 27 Receptor, Alpha) is a Protein Coding gene. Among its related pathways are Th1 Differentiation and Th1 Differentiation. GO annotations related to this gene include transmembrane signaling receptor activity and interleukin-27 receptor activity.

UniProtKB/Swiss-Prot for IL27RA Gene

  • Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

Gene Wiki entry for IL27RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL27RA Gene

Genomics for IL27RA Gene

Genomic Location for IL27RA Gene

14,031,740 bp from pter
14,053,216 bp from pter
21,477 bases
Plus strand

Genomic View for IL27RA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL27RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL27RA Gene

Regulatory Elements for IL27RA Gene

Proteins for IL27RA Gene

  • Protein details for IL27RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-27 receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • A0N0L1
    • O60624

    Protein attributes for IL27RA Gene

    636 amino acids
    Molecular mass:
    69474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL27RA Gene

Proteomics data for IL27RA Gene at MOPED

Post-translational modifications for IL27RA Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn51, Asn76, Asn302, Asn311, Asn374, Asn382, and Asn467

Other Protein References for IL27RA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL27RA Gene

Domains for IL27RA Gene

Gene Families for IL27RA Gene

  • FN3 :Fibronectin type III domain containing
  • IL :Interleukins and interleukin receptors

Protein Domains for IL27RA Gene


  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding:
    • Q6UWB1
  • The box 1 motif is required for JAK interaction and/or activation:
    • Q6UWB1
  • Contains 3 fibronectin type-III domains.:
    • Q6UWB1
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.:
    • Q6UWB1
genes like me logo Genes that share domains with IL27RA: view

Function for IL27RA Gene

Molecular function for IL27RA Gene

UniProtKB/Swiss-Prot Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

Gene Ontology (GO) - Molecular Function for IL27RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9600072
GO:0005515 protein binding --
GO:0045509 interleukin-27 receptor activity IEA --
genes like me logo Genes that share ontologies with IL27RA: view
genes like me logo Genes that share phenotypes with IL27RA: view

Animal Models for IL27RA Gene

MGI Knock Outs for IL27RA:

miRNA for IL27RA Gene

miRTarBase miRNAs that target IL27RA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL27RA Gene

Localization for IL27RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL27RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL27RA Gene COMPARTMENTS Subcellular localization image for IL27RA gene
Compartment Confidence
plasma membrane 4
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL27RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9600072
genes like me logo Genes that share ontologies with IL27RA: view

Pathways for IL27RA Gene

SuperPathways for IL27RA Gene

genes like me logo Genes that share pathways with IL27RA: view

Pathways by source for IL27RA Gene

1 R&D Systems pathway for IL27RA Gene
1 BioSystems pathway for IL27RA Gene

Gene Ontology (GO) - Biological Process for IL27RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002827 positive regulation of T-helper 1 type immune response IEA --
GO:0002829 negative regulation of type 2 immune response IEA --
GO:0006955 immune response TAS 9600072
GO:0007166 cell surface receptor signaling pathway TAS 9600072
GO:0032729 positive regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IL27RA: view

Transcripts for IL27RA Gene

mRNA/cDNA for IL27RA Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(81) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL27RA Gene

Interleukin 27 receptor, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL27RA Gene

No ASD Table

Relevant External Links for IL27RA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL27RA Gene

mRNA expression in normal human tissues for IL27RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL27RA Gene

This gene is overexpressed in Whole Blood (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL27RA Gene

SOURCE GeneReport for Unigene cluster for IL27RA Gene Hs.132781

mRNA Expression by UniProt/SwissProt for IL27RA Gene

Tissue specificity: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.
genes like me logo Genes that share expressions with IL27RA: view

Orthologs for IL27RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL27RA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL27RA 36
  • 99.14 (n)
  • 98.5 (a)
IL27RA 37
  • 99 (a)
(Bos Taurus)
Mammalia IL27RA 36
  • 79.61 (n)
  • 73.03 (a)
IL27RA 37
  • 69 (a)
(Canis familiaris)
Mammalia IL27RA 36
  • 82.04 (n)
  • 77.76 (a)
IL27RA 37
  • 71 (a)
(Mus musculus)
Mammalia Il27ra 36
  • 73.06 (n)
  • 64.48 (a)
Il27ra 16
Il27ra 37
  • 62 (a)
(Rattus norvegicus)
Mammalia Il27ra 36
  • 71.68 (n)
  • 62.62 (a)
(Anolis carolinensis)
Reptilia IL27RA 37
  • 31 (a)
Species with no ortholog for IL27RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL27RA Gene

Gene Tree for IL27RA (if available)
Gene Tree for IL27RA (if available)

Paralogs for IL27RA Gene

No data available for Paralogs for IL27RA Gene

Variants for IL27RA Gene

Sequence variations from dbSNP and Humsavar for IL27RA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2126914 -- 14,038,411(-) TTGTA(A/G)AAATG intron-variant
rs2306190 -- 14,051,864(-) AGGAG(G/T)AGTCA intron-variant
rs2306191 -- 14,032,339(-) CCCCC(C/G)CTTCC intron-variant
rs2306192 -- 14,032,204(-) GTGCT(C/T)GCCAC intron-variant
rs2420413 -- 14,043,008(+) GTGGT(A/C/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL27RA Gene

Variant ID Type Subtype PubMed ID
nsv911102 CNV Loss 21882294
dgv3739n71 CNV Loss 21882294
dgv3741n71 CNV Loss 21882294
nsv833761 CNV Loss 17160897

Relevant External Links for IL27RA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for IL27RA Gene

Relevant External Links for IL27RA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL27RA: view

No data available for UniProtKB/Swiss-Prot for IL27RA Gene

Publications for IL27RA Gene

  1. Cloning and characterization of a novel class I cytokine receptor. (PMID: 9600072) Sprecher C.A. … Foster D.F. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. (PMID: 11057672) Chen Q. … de Sauvage F.J. (Nature 2000) 2 3 4
  3. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. (PMID: 19386761) Hashimoto Y. … Matsuoka M. (Mol. Biol. Cell 2009) 3 23
  4. Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance. (PMID: 19549909) Dibra D. … Li S. (Cancer Res. 2009) 3 23
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for IL27RA Gene

Sources for IL27RA Gene

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