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IL27RA Gene

protein-coding   GIFtS: 58
GCID: GC19P014142

Interleukin 27 Receptor, Alpha

Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 27 Receptor, Alpha1 2     IL-27RA2 3
TCCR2 3 5     IL-27 Receptor Subunit Alpha2 3
WSX12 3 5     IL-27R Subunit Alpha2 3
T-Cell Cytokine Receptor Type 11 2     IL27R2
Cytokine Receptor WSX-12 3     Class I Cytokine Receptor2
Cytokine Receptor-Like 12 3     Interleukin-27 Receptor Subunit Alpha2
Type I T-Cell Cytokine Receptor2 3     zcytor12
CRL12 3     ZcytoR13
IL-27R-alpha2 3     

External Ids:    HGNC: 172901   Entrez Gene: 94662   Ensembl: ENSG000001049987   OMIM: 6053505   UniProtKB: Q6UWB13   

Export aliases for IL27RA gene to outside databases

Previous GC identifers: GC19P014003 GC19P013714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL27RA Gene:
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity,
predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells,
which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated
transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a
protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to
be a glycosylated transmembrane protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL27RA Gene:
IL27RA (interleukin 27 receptor, alpha) is a protein-coding gene. Diseases associated with IL27RA include membranous glomerulonephritis, and age related macular degeneration. GO annotations related to this gene include transmembrane signaling receptor activity and interleukin-27 receptor activity.

UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This
signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also
appears to be involved in innate defense mechanisms

Gene Wiki entry for IL27RA (Interleukin 27 receptor, alpha subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL27RA gene promoter:
         SRF   NF-1   NF-1/L   SRF (504 AA)   GATA-1   AREB6   PPAR-gamma1   STAT3   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL27RA promoter sequence
   Search Chromatin IP Primers for IL27RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL27RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.11

IL27RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL27RA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014142:  view genomic region     (about GC identifiers)

Start:
14,142,262 bp from pter      End:
14,164,026 bp from pter
Size:
21,765 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1 (See protein sequence)
Recommended Name: Interleukin-27 receptor subunit alpha precursor  
Size: 636 amino acids; 69474 Da
Secondary accessions: A0N0L1 O60624

Explore the universe of human proteins at neXtProt for IL27RA: NX_Q6UWB1

Explore proteomics data for IL27RA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51, Asn76, Asn302, Asn311, Asn374, Asn382, Asn467
  • Modification sites at PhosphoSitePlus

  • See IL27RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004834.1  
    ENSEMBL proteins: 
     ENSP00000263379  

    IL27RA Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 27 receptor, alpha
    IL-6 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6UWB1

    ProtoNet protein and cluster: Q6UWB1

    1 Blocks protein domain: IPB003529 Long hematopoietin receptor

    UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 3 fibronectin type-III domains


    IL27RA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I27RA_HUMAN, Q6UWB1
    Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This
    signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also
    appears to be involved in innate defense mechanisms

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9600072
    GO:0005515protein binding ----
    GO:0045509interleukin-27 receptor activity IEA--
         
    IL27RA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL27RA:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il27ra):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  renal/urinary system  skeleton 

    IL27RA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL27RA: Il27ratm1Fjs Il27ratm1Mak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL27RA
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL27RA

    miRNA
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    miRTarBase miRNAs that target IL27RA:
    hsa-mir-1 (MIRT023830), hsa-mir-124-3p (MIRT022747)

    Block miRNA regulation of human, mouse, rat IL27RA using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IL27RA:
    hsa-miR-3909 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIL27RA 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for IL27RA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27RA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I27RA_HUMAN, Q6UWB1: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS9600072

    IL27RA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL27RA About    
    See pathways by source

    SuperPathContained pathways About
    1Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL27RA
        Th1 Differentiation


    1 BioSystems Pathway for IL27RA
        IL27-mediated signaling events



        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL27RA: 
              Th1/Th2 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL27RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for IL27RA (Q6UWB13 ENSP000002633794) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EBI3Q142133, ENSP000002218474I2D: score=3 STRING: ENSP00000221847
    STAT1P422243, ENSP000003543944I2D: score=3 STRING: ENSP00000354394
    IL27Q8NEV93, ENSP000003493654I2D: score=2 STRING: ENSP00000349365
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    JAK1P234583, ENSP000003432044I2D: score=1 STRING: ENSP00000343204
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002827positive regulation of T-helper 1 type immune response IEA--
    GO:0002829negative regulation of type 2 immune response IEA--
    GO:0006955immune response TAS9600072
    GO:0007166cell surface receptor signaling pathway TAS9600072
    GO:0032729positive regulation of interferon-gamma production IEA--

    IL27RA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL27RA (I27RA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL27RA gene: 
    NM_004843.3  

    Unigene Cluster for IL27RA:

    Interleukin 27 receptor, alpha
    Hs.132781  [show with all ESTs]
    Unigene Representative Sequence: NM_004843
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263379(uc002mxx.3)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate IL27RA:
    hsa-miR-3909 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIL27RA 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL27RA
      QuantiTect SYBR Green Assays in human, mouse, rat IL27RA
      QuantiFast Probe-based Assays in human, mouse, rat IL27RA

    Additional mRNA sequence: 

    AF053004.1 AF106912.1 AF265242.1 AY358876.1 BC028003.1 

    1 DOTS entry:

    DT.108308 

    Selected AceView cDNA sequences (see all 81):

    AF106912 AI347487 CA426655 BM761233 BC028003 BM762764 AI769137 NM_080864 
    AW575269 BU632122 BF829683 BQ919454 AB076563 BP337994 BM804052 BM760781 
    NM_004843 AF447451 BM764289 BM844856 BQ927024 AF265242 BF827655 BF829689 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL27RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCACACA
    IL27RA Expression
    About this image


    IL27RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Gonad
             Primordial germ cell-like cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
    IL27RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL27RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132781

    UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
    Tissue specificity: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood
    leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver,
    skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid
    system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in
    CD19+ B-cells and monocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL27RA: 
              Th1/Th2 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IL27RA
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL27RA gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il27ra1 , 5 interleukin 27 receptor, alpha1, 5 73.06(n)1
    64.48(a)1
      8 (40.26 cM)5
    509311  NM_016671.31  NP_057880.21 
     840302875 
    lizard
    (Anolis carolinensis)
    Reptilia IL27RA6
    interleukin 27 receptor, alpha
    31(a)
    1 ↔ 1
    2(76775728-76825228)


    ENSEMBL Gene Tree for IL27RA (if available)
    TreeFam Gene Tree for IL27RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL27RA (see all 593)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388090481,2
    C--14142371(+) AGAGA-/GTGTGTG 1 -- us2k10--------
    rs744009831,2
    C--14142413(+) GGTTTC/TGGGGA 1 -- us2k14Minor allele frequency- T:0.10CSA WA EA 240
    rs65119051,2
    C,F,A--14142616(+) GAGCTG/CGAAGA 1 -- ut519Minor allele frequency- C:0.49NA CSA WA EA 491
    rs1135934391,2
    C,F--14142705(+) GGCGCC/TCCTTT 2 A syn16Minor allele frequency- T:0.09CSA WA NA EA 2731
    rs1492339371,2
    --14142876(+) GCAGAA/GCGAAC 1 -- int10--------
    rs23061921,2
    C,F,A,H--14143016(-) GTGCTC/TGCCAC 1 -- int124Minor allele frequency- T:0.45EA NA NS WA CSA 3906
    rs1160050201,2
    F--14143030(+) GAAAGG/CGGGGG 1 -- int11Minor allele frequency- C:0.01WA 118
    rs72527081,2
    C,F,A--14143057(+) GCAGGG/AGTGCC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1132662851,2
    C--14143096(+) CTAAGC/-CCCCC 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs129728711,2
    H--14143131(+) AAGTTC/TTGGGG 1 -- int14Minor allele frequency- T:0.00NS EA 416

    HapMap Linkage Disequilibrium report for IL27RA (14142262 - 14164026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IL27RA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911102CNV Loss21882294
    dgv3741n71CNV Loss21882294
    nsv833761CNV Loss17160897
    dgv3739n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL27RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL27RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605350    OMIM disorders: --

    10 diseases for IL27RA:    
    About MalaCards
    membranous glomerulonephritis    age related macular degeneration    glomerulonephritis    bronchiolitis
    encephalomyelitis    nasopharyngitis    myelodysplastic syndromes    neuronitis
    prostatitis    thyroiditis


    IL27RA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): IL27RA
    Human Genome Epidemiology (HuGE) Navigator: IL27RA (3 documents)

    Export disorders for IL27RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL27RA gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with IL27RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. (PubMed id 11057672)1, 2, 3 Chen Q.... de Sauvage F.J. (Nature 2000)
    2. Cloning and characterization of a novel class I cytokine receptor. (PubMed id 9600072)1, 2, 3 Sprecher C.A.... Foster D.F. (Biochem. Biophys. Res. Commun. 1998)
    3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    4. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    6. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. (PubMed id 14764690)1, 2 Pflanz S....Kastelein R.A. (J. Immunol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance. (PubMed id 19549909)1, 9 Dibra D....Li S. (Cancer Res. 2009)
    10. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. (PubMed id 19386761)1, 9 Hashimoto Y....Matsuoka M. (Mol. Biol. Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9466 HGNC: 17290 AceView: IL27RAandRLN3 Ensembl:ENSG00000104998 euGenes: HUgn9466
    ECgene: IL27RA H-InvDB: IL27RA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL27RA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL27RA gene:
    Search GeneIP for patents involving IL27RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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