Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL27RA Gene

protein-coding   GIFtS: 57
GCID: GC19P014142

Interleukin 27 Receptor, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 27 Receptor, Alpha1 2     IL-27RA2 3
TCCR2 3 5     IL-27 Receptor Subunit Alpha2 3
WSX12 3 5     IL-27R Subunit Alpha2 3
T-Cell Cytokine Receptor Type 11 2     IL27R2
Cytokine Receptor WSX-12 3     Class I Cytokine Receptor2
Cytokine Receptor-Like 12 3     Interleukin-27 Receptor Subunit Alpha2
Type I T-Cell Cytokine Receptor2 3     zcytor12
CRL12 3     ZcytoR13
IL-27R-alpha2 3     

External Ids:    HGNC: 172901   Entrez Gene: 94662   Ensembl: ENSG000001049987   OMIM: 6053505   UniProtKB: Q6UWB13   

Export aliases for IL27RA gene to outside databases

Previous GC identifers: GC19P014003 GC19P013714


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL27RA Gene:
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity,
predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells,
which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated
transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a
protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to
be a glycosylated transmembrane protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL27RA Gene: 
IL27RA (interleukin 27 receptor, alpha) is a protein-coding gene. Diseases associated with IL27RA include membranous glomerulonephritis, and glomerulonephritis, and among its related super-pathways are Th1 Differentiation. GO annotations related to this gene include transmembrane signaling receptor activity and interleukin-27 receptor activity.

UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This
signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also
appears to be involved in innate defense mechanisms

Gene Wiki entry for IL27RA (Interleukin 27 receptor, alpha subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL27RA gene promoter:
         SRF   NF-1   NF-1/L   SRF (504 AA)   GATA-1   AREB6   PPAR-gamma1   STAT3   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL27RA promoter sequence
   Search SABiosciences Chromatin IP Primers for IL27RA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL27RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.11

IL27RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL27RA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014142:  view genomic region     (about GC identifiers)

Start:
14,142,262 bp from pter      End:
14,164,026 bp from pter
Size:
21,765 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1 (See protein sequence)
Recommended Name: Interleukin-27 receptor subunit alpha precursor  
Size: 636 amino acids; 69474 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A0N0L1 O60624

Explore the universe of human proteins at neXtProt for IL27RA: NX_Q6UWB1

Explore proteomics data for IL27RA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UWB1

  • IL27RA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL27RA Protein Expression
    REFSEQ proteins: NP_004834.1  
    ENSEMBL proteins: 
     ENSP00000263379  

    Human Recombinant Protein Products for IL27RA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL27RA (IL-27 R alpha/WSX-1/TCCR)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL27RA
    OriGene Protein Over-expression Lysate for IL27RA
    OriGene MassSpec for IL27RA 
    OriGene Custom Protein Services for IL27RA
    GenScript Custom Purified and Recombinant Proteins Services for IL27RA
    Novus Biologicals IL27RA Proteins
    Novus Biologicals IL27RA Lysate
    Sino Biological Recombinant Protein for IL27RA
    Sino Biological Cell Lysate for IL27RA 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9600072

    IL27RA for ontologies           About GeneDecksing



    IL27RA Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL27RA (IL-27 R alpha/WSX-1/TCCR)
    OriGene Antibodies for IL27RA
    OriGene Custom Antibody Services for IL27RA
    GenScript Custom Superior Antibodies Services for IL27RA
    Novus Biologicals IL27RA Antibodies
    Abcam antibodies for IL27RA
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for IL27RA
    LSBio Antibodies in human, mouse, rat for IL27RA 

    Assay Products for IL27RA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL27RA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IL27RA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 27 receptor, alpha 
    IL-6 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6UWB1

    ProtoNet protein and cluster: Q6UWB1

    1 Blocks protein domain: IPB003529 Long hematopoietin receptor

    UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 3 fibronectin type-III domains


    IL27RA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I27RA_HUMAN, Q6UWB1
    Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This
    signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also
    appears to be involved in innate defense mechanisms

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9600072
    GO:0005515protein binding ----
    GO:0045509interleukin-27 receptor activity IEA--
         
    IL27RA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL27RA:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il27ra):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  renal/urinary system  skeleton 

    IL27RA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL27RA: Il27ratm1Fjs Il27ratm1Mak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL27RA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL27RA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL27RA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL27RA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL27RA
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL27RA:
    hsa-miR-3909 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIL27RA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL27RA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL27RA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL27RA
    Sirion Biotech Customized adenovirus for overexpression of IL27RA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL27RA (see all 7)
    OriGene ORF clones in mouse, rat for IL27RA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL27RA (NM_004843)
    Sino Biological Human cDNA Clone for IL27RA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL27RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL27RA
    Sirion Biotech Customized lentivirus for stable overexpression of IL27RA 
                         Customized lentivirus expression plasmids for stable overexpression of IL27RA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL27RA
    Search LifeMap BioReagents cell lines for IL27RA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27RA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL27RA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1IL27-mediated signaling events
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL27RA
        Th1 Differentiation


    1 BioSystems Pathway for IL27RA
        IL27-mediated signaling events



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL27RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for IL27RA (Q6UWB13 ENSP000002633794) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EBI3Q142133, ENSP000002218474I2D: score=3 STRING: ENSP00000221847
    STAT1P422243, ENSP000003543944I2D: score=3 STRING: ENSP00000354394
    IL27Q8NEV93, ENSP000003493654I2D: score=2 STRING: ENSP00000349365
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    JAK1P234583, ENSP000003432044I2D: score=1 STRING: ENSP00000343204
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002827positive regulation of T-helper 1 type immune response IEA--
    GO:0002829negative regulation of type 2 immune response IEA--
    GO:0006955immune response TAS9600072
    GO:0007166cell surface receptor signaling pathway TAS9600072
    GO:0032729positive regulation of interferon-gamma production IEA--

    IL27RA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL27RA (I27RA)

    Search CenterWatch for drugs/clinical trials and news about IL27RA / I27RA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL27RA gene: 
    NM_004843.3  

    Unigene Cluster for IL27RA:

    Interleukin 27 receptor, alpha
    Hs.132781  [show with all ESTs]
    Unigene Representative Sequence: NM_004843
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263379(uc002mxx.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL27RA
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL27RA:
    hsa-miR-3909 hsa-miR-3921 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIL27RA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL27RA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL27RA
    Clone
    Products:
         
    OriGene clones in human, mouse for IL27RA (see all 7)
    OriGene ORF clones in mouse, rat for IL27RA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL27RA (NM_004843)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL27RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL27RA
    Sirion Biotech Customized lentivirus for stable overexpression of IL27RA 
                         Customized lentivirus expression plasmids for stable overexpression of IL27RA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL27RA
    OriGene qSTAR qPCR primer pairs in human, mouse for IL27RA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL27RA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL27RA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL27RA

    Additional mRNA sequence: 

    AF053004.1 AF106912.1 AF265242.1 AY358876.1 BC028003.1 

    1 DOTS entry:

    DT.108308 

    24/81 AceView cDNA sequences (see all 81):

    AF447451 BM762764 AW575269 BF829683 BU632122 NM_004843 BM761233 AI769137 
    AI347487 BM760781 AB076563 BP337994 BM764289 AF106912 NM_080864 BC028003 
    BM804052 CA426655 BQ919454 BF827655 BM761623 BM048281 BX283853 AW298502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL27RA expression in normal human tissues (normalized intensities)      IL27RA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCACACA
    IL27RA Expression
    About this image


    IL27RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T Helper Cells Thymus
             umbilical cord reticulocytes   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Thyroid (Endocrine System)
     
     Stomach (Gastrointestinal Tract)

    See IL27RA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL27RA

    SOURCE GeneReport for Unigene cluster: Hs.132781

    UniProtKB/Swiss-Prot: I27RA_HUMAN, Q6UWB1
    Tissue specificity: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood
    leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver,
    skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid
    system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in
    CD19+ B-cells and monocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL27RA: 
              Th1/Th2 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL27RA
    OriGene qSTAR qPCR primer pairs in human, mouse for IL27RA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL27RA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL27RA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL27RA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL27RA gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il27ra1 , 5 interleukin 27 receptor, alpha1, 5 72.51(n)1
    63.77(a)1
      8 (40.26 cM)5
    509311  NM_016671.31  NP_057880.21 
     840302875 
    lizard
    (Anolis carolinensis)
    Reptilia IL27RA6
    interleukin 27 receptor, alpha
    31(a)
    1 ↔ 1
    2(76775728-76825228)


    ENSEMBL Gene Tree for IL27RA (if available)
    TreeFam Gene Tree for IL27RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/593 SNPs in IL27RA are shown (see all 593)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388090481,2
    C--14142371(+) AGAGA-/GTGTGTG 1 -- us2k10--------
    rs744009831,2
    C--14142413(+) GGTTTC/TGGGGA 1 -- us2k14Minor allele frequency- T:0.10CSA WA EA 240
    rs65119051,2
    C,F,A--14142616(+) GAGCTG/CGAAGA 1 -- ut519Minor allele frequency- C:0.49NA CSA WA EA 491
    rs1135934391,2
    C,F--14142705(+) GGCGCC/TCCTTT 2 A syn16Minor allele frequency- T:0.09CSA WA NA EA 2731
    rs1492339371,2
    --14142876(+) GCAGAA/GCGAAC 1 -- int10--------
    rs23061921,2
    C,F,A,H--14143016(-) GTGCTC/TGCCAC 1 -- int124Minor allele frequency- T:0.45EA NA NS WA CSA 3906
    rs1160050201,2
    F--14143030(+) GAAAGG/CGGGGG 1 -- int11Minor allele frequency- C:0.01WA 118
    rs72527081,2
    C,F,A--14143057(+) GCAGGG/AGTGCC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1132662851,2
    C--14143096(+) CTAAGC/-CCCCC 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs129728711,2
    H--14143131(+) AAGTTC/TTGGGG 1 -- int14Minor allele frequency- T:0.00NS EA 416

    HapMap Linkage Disequilibrium report for IL27RA (14142262 - 14164026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IL27RA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911102CNV Loss21882294
    dgv3741n71CNV Loss21882294
    nsv833761CNV Loss17160897
    dgv3739n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL27RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL27RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605350    OMIM disorders: --

    9 diseases for IL27RA:    About MalaCards
    membranous glomerulonephritis    glomerulonephritis    bronchiolitis    encephalomyelitis
    nasopharyngitis    age related macular degeneration    macular degeneration    prostatitis
    neuronitis


    IL27RA for disorders           About GeneDecksing

    Genetic Association Database (GAD): IL27RA
    Human Genome Epidemiology (HuGE) Navigator: IL27RA (3 documents)

    Export disorders for IL27RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL27RA gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with IL27RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. (PubMed id 11057672)1, 2, 3 Chen Q....de Sauvage F.J. (2000)
    2. Cloning and characterization of a novel class I cytokine receptor. (PubMed id 9600072)1, 2, 3 Sprecher C.A.... Foster D.F. (1998)
    3. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    4. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    6. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. (PubMed id 14764690)1, 2 Pflanz S....Kastelein R.A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Expression of WSX1 in tumors sensitizes IL-27 signali ng-independent natural killer cell surveillance. (PubMed id 19549909)1, 9 Dibra D....Li S. (2009)
    10. Humanin inhibits neuronal cell death by interacting w ith a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX- 1/gp130. (PubMed id 19386761)1, 9 Hashimoto Y....Matsuoka M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9466 HGNC: 17290 AceView: IL27RAandRLN3 Ensembl:ENSG00000104998 euGenes: HUgn9466
    ECgene: IL27RA H-InvDB: IL27RA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL27RA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL27RA gene:
    Search GeneIP for patents involving IL27RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IL27RA (IL-27 R alpha/WSX-1/TCCR)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IL27RA (IL-27 R alpha/WSX-1/TCCR)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IL27RA   OriGene RNAi products in human, mouse, rat for IL27RA  
     OriGene qPCR primer pairs and template standards for IL27RA   OriGene Protein Over-expression Lysate for IL27RA  
     OriGene MassSpec something-or-other for IL27RA   OriGene clones in human, mouse for IL27RA  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL27RA   OriGene Purified Protein for IL27RA  
     OriGene ORF clones in mouse, rat for IL27RA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL27RA   OriGene Custom Protein Services for IL27RA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL27RA
     QIAGEN SeqTarget long-range PCR primers for resequencing IL27RA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL27RA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL27RA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL27RA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL27RA
     GenScript Custom Purified and Recombinant Proteins Services for IL27RA GenScript cDNA clones with any tag delivered in your preferred vector for IL27RA
     GenScript Custom Assay Services for IL27RA GenScript Custom Superior Antibodies Services for IL27RA
     GenScript Custom overexpressing Cell Line Services for IL27RA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IL27RA promoter
     Search Chromatin IP Primers for IL27RA
     RT2 qPCR Primer Assay in human, mouse, rat IL27RA
     GNC Network for IL27RA
     SABiosciences PCR Arrays including human, mouse, rat IL27RA
     Search Tocris compounds for IL27RA (I27RA)
     Proteins and Antibodies for IL27RA
     Cell Lysates for IL27RA
     cDNA Clones for IL27RA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IL27RA antibodies
     IL27RA proteins
     IL27RA lysates
     Antibodies for IL27RA
     See all of Abcam's Antibodies, Kits and Proteins for IL27RA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for IL27RA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27RA
     SwitchGear 3'UTR luciferase reporter plasmids for IL27RA
     SwitchGear Promoter luciferase reporter plasmids for IL27RA
     ThermoFisher Antibodies for IL27RA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL27RA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IL27RA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL27RA
    Customized:
     lentivirus for stable overexpression of IL27RA
     lentivirus expression plasmids for stable overexpression of IL27RA
     adenovirus for overexpression of IL27RA
     LSBio Antibodies in human, mouse, rat for IL27RA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL27RA gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4