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Aliases for IL27 Gene

Aliases for IL27 Gene

  • Interleukin 27 2 3
  • IL30 3 4 6
  • IL-27 Subunit Alpha 3 4
  • Interleukin 30 2 3
  • Interleukin-30 3 4
  • IL-27-A 3 4
  • IL27-A 3 4
  • IL27A 3 4
  • P28 3 4
  • Interleukin-27 Subunit Alpha 3
  • IL-27 P28 Subunit 3
  • IL27p28 3
  • IL-27A 3
  • IL-27 3

External Ids for IL27 Gene

Previous Symbols for IL27 Gene

  • IL30

Summaries for IL27 Gene

Entrez Gene Summary for IL27 Gene

  • The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

GeneCards Summary for IL27 Gene

IL27 (Interleukin 27) is a Protein Coding gene. Diseases associated with IL27 include eosinophilic granulomatosis with polyangiitis and posterior uveitis. Among its related pathways are Th1 Differentiation and Th1 Differentiation. GO annotations related to this gene include receptor binding and interleukin-27 receptor binding.

UniProtKB/Swiss-Prot for IL27 Gene

  • Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL27 Gene

Genomics for IL27 Gene

Genomic Location for IL27 Gene

Start:
28,499,362 bp from pter
End:
28,512,051 bp from pter
Size:
12,690 bases
Orientation:
Minus strand

Genomic View for IL27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL27 Gene

Regulatory Elements for IL27 Gene

Proteins for IL27 Gene

  • Protein details for IL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEV9-IL27A_HUMAN
    Recommended name:
    Interleukin-27 subunit alpha
    Protein Accession:
    Q8NEV9
    Secondary Accessions:
    • A0N0L2
    • Q6P676

    Protein attributes for IL27 Gene

    Size:
    243 amino acids
    Molecular mass:
    27493 Da
    Quaternary structure:
    • Heterodimer with EBI3; not disulfide-linked. This heterodimer is known as interleukin IL-27.

neXtProt entry for IL27 Gene

Proteomics data for IL27 Gene at MOPED

Post-translational modifications for IL27 Gene

Other Protein References for IL27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL27 Gene

Domains for IL27 Gene

Gene Families for IL27 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEV9

UniProtKB/Swiss-Prot:

IL27A_HUMAN
Family:
  • Belongs to the IL-6 superfamily.:
    • Q8NEV9
genes like me logo Genes that share domains with IL27: view

Function for IL27 Gene

Molecular function for IL27 Gene

UniProtKB/Swiss-Prot Function: Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.
UniProtKB/Swiss-Prot Induction: Transiently induced by bacterial lipopolysaccharides (LPS) stimulation in monocytes.

Gene Ontology (GO) - Molecular Function for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS --
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding --
GO:0045523 interleukin-27 receptor binding ISS --
genes like me logo Genes that share ontologies with IL27: view
genes like me logo Genes that share phenotypes with IL27: view

Animal Models for IL27 Gene

MGI Knock Outs for IL27:

miRNA for IL27 Gene

miRTarBase miRNAs that target IL27

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL27 Gene

Localization for IL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL27 Gene

Secreted. Note=Does not seem to be secreted without coexpression of EBI3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL27 Gene COMPARTMENTS Subcellular localization image for IL27 gene
Compartment Confidence
extracellular 5
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
genes like me logo Genes that share ontologies with IL27: view

Pathways for IL27 Gene

SuperPathways for IL27 Gene

genes like me logo Genes that share pathways with IL27: view

Pathways by source for IL27 Gene

1 R&D Systems pathway for IL27 Gene
1 BioSystems pathway for IL27 Gene

Gene Ontology (GO) - Biological Process for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0009617 response to bacterium IEA --
GO:0042129 regulation of T cell proliferation ISS --
GO:0045078 positive regulation of interferon-gamma biosynthetic process IDA 12734330
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with IL27: view

Transcripts for IL27 Gene

mRNA/cDNA for IL27 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL27 Gene

Interleukin 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL27 Gene

No ASD Table

Relevant External Links for IL27 Gene

GeneLoc Exon Structure for
IL27
ECgene alternative splicing isoforms for
IL27

Expression for IL27 Gene

mRNA expression in normal human tissues for IL27 Gene

mRNA differential expression in normal tissues according to GTEx for IL27 Gene

This gene is overexpressed in Liver (26.4) and Whole Blood (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL27 Gene

SOURCE GeneReport for Unigene cluster for IL27 Gene Hs.528111

mRNA Expression by UniProt/SwissProt for IL27 Gene

Q8NEV9-IL27A_HUMAN
Tissue specificity: Expressed in monocytes and in placenta.
genes like me logo Genes that share expressions with IL27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL27 Gene

Orthologs for IL27 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL27 35
  • 99.35 (n)
  • 99.35 (a)
IL27 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL27 35
  • 79.72 (n)
  • 74.47 (a)
IL27 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL27 35
  • 77.78 (n)
  • 68.47 (a)
IL27 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il27 35
  • 82.35 (n)
  • 79.19 (a)
Il27 16
Il27 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL27 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL27 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il27 35
  • 80.69 (n)
  • 76.47 (a)
Species with no ortholog for IL27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL27 Gene

ENSEMBL:
Gene Tree for IL27 (if available)
TreeFam:
Gene Tree for IL27 (if available)

Paralogs for IL27 Gene

No data available for Paralogs for IL27 Gene

Variants for IL27 Gene

Sequence variations from dbSNP and Humsavar for IL27 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs26528 -- 28,506,388(-) GGAGC(A/G)CTGGG intron-variant
rs34833 -- 28,506,584(-) ACCCA(A/G)GGCTG intron-variant
rs40837 -- 28,499,524(+) GGTAG(A/G)GCCTG utr-variant-3-prime
rs153109 -- 28,507,775(+) AGGCT(C/T)GAGTT upstream-variant-2KB
rs153110 -- 28,505,398(+) gtggc(A/G)cgatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL27 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv833180 CNV Loss 17160897
nsv905688 CNV Gain 21882294
nsv509608 CNV Insertion 20534489
nsv905689 CNV Loss 21882294

Relevant External Links for IL27 Gene

HapMap Linkage Disequilibrium report
IL27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL27 Gene

Disorders for IL27 Gene

(3) Novoseek inferred disease relationships for IL27 Gene

Disease -log(P) Hits PubMed IDs
encephalomyelitis 44.8 2
lymphoma 2.64 1
tumors 0 1

Relevant External Links for IL27

Genetic Association Database (GAD)
IL27
Human Genome Epidemiology (HuGE) Navigator
IL27
genes like me logo Genes that share disorders with IL27: view

No data available for UniProtKB/Swiss-Prot for IL27 Gene

Publications for IL27 Gene

  1. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. (PMID: 17318299) Chae S.-C. … Chung H.-T. (J. Hum. Genet. 2007) 3 4 23 48
  2. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. (PMID: 12121660) Pflanz S. … Kastelein R.A. (Immunity 2002) 2 3 4
  3. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. (PMID: 19686419) Li C.S. … Chae S.C. (J. Gastroenterol. Hepatol. 2009) 3 23 48
  4. Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL- 27. (PMID: 17068156) Fakruddin J.M. … Imamichi T. (Blood 2007) 3 4
  5. Interleukin-27 upregulates major histocompatibility complex class II expression in primary human endothelial cells through induction of major histocompatibility complex class II transactivator. (PMID: 18191724) Feng X.M. … Han Z.C. (Hum. Immunol. 2007) 3 4

Products for IL27 Gene

Sources for IL27 Gene

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