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IL27 Gene

protein-coding   GIFtS: 53
GCID: GC16M028511

Interleukin 27

(Previous name: interleukin 30)
(Previous symbol: IL30)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 271 2     p282 3
IL301 2 5     IL-272
Interleukin 301 2     IL-27A2
IL-27-A2 3     IL27p282
IL27-A2 3     IL-27 P28 Subunit2
IL27A2 3     Interleukin-27 Subunit Alpha2
IL-27 Subunit Alpha2 3     

External Ids:    HGNC: 191571   Entrez Gene: 2467782   Ensembl: ENSG000001972727   OMIM: 6082735   UniProtKB: Q8NEV93   

Export aliases for IL27 gene to outside databases

Previous GC identifers: GC16P028586 GC16M028418 GC16M026536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL27 Gene:
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is
related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar
to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not
memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon
gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the
class I cytokine receptor (WSX1/TCRR). (provided by RefSeq, Jul 2008)

GeneCards Summary for IL27 Gene:
IL27 (interleukin 27) is a protein-coding gene. Diseases associated with IL27 include eosinophilic granulomatosis with polyangiitis, and granulomatosis with polyangiitis. GO annotations related to this gene include interleukin-27 receptor binding and receptor binding.

UniProtKB/Swiss-Prot: IL27A_HUMAN, Q8NEV9
Function: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development,
suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that
has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate
in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives
rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger
interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which
appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early
phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via
two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3,
STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an
event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development.
In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell
development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of
IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it
inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27
has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4,
IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of
cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on
T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with
activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial
cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II
transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also
demonstrates antiviral activity with inhibitory properties on HIV-1 replivation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL27 gene promoter:
         C/EBPbeta   AP-1   Bach2   ATF-2   c-Jun   IRF-1   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL27 promoter sequence
   Search Chromatin IP Primers for IL27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11

IL27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL27 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028511:  view genomic region     (about GC identifiers)

Start:
28,510,683 bp from pter      End:
28,523,372 bp from pter
Size:
12,690 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL27A_HUMAN, Q8NEV9 (See protein sequence)
Recommended Name: Interleukin-27 subunit alpha precursor  
Size: 243 amino acids; 27493 Da
Subunit: Heterodimer with IL27B/EBI3. IL-27 is a heterodimer composed IL27 and EBI3. EBI3 is also a component of
the IL-12 heterodimer
Secondary accessions: A0N0L2 Q6P676

Explore the universe of human proteins at neXtProt for IL27: NX_Q8NEV9

Explore proteomics data for IL27 at MOPED

Post-translational modifications: 

  • O-glycosylated (Probable)1
  • Modification sites at neXtProt

  • See IL27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_663634.2  
    ENSEMBL proteins: 
     ENSP00000349365   ENSP00000455990  

    IL27 Human Recombinant Protein Products:

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    IL27 Antibody Products:

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    Novus Biologicals IL27 Antibodies
    Abcam antibodies for IL27 (Q8NEV9, Q14213)
    Cloud-Clone Corp. Antibodies for IL27
    ThermoFisher Antibodies for IL27
    LSBio Antibodies in human, mouse, rat for IL27

    IL27 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IL27 (IL-27)         (see all)
    GenScript Custom Assay Services for IL27
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL27
    Cloud-Clone Corp. CLIAs for IL27


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    1 InterPro protein domain:
     IPR026207 IL-27_alpha

    Graphical View of Domain Structure for InterPro Entry Q8NEV9

    ProtoNet protein and cluster: Q8NEV9

    UniProtKB/Swiss-Prot: IL27A_HUMAN, Q8NEV9
    Similarity: Belongs to the IL-6 superfamily


    IL27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL27A_HUMAN, Q8NEV9
    Function: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development,
    suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that
    has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate
    in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives
    rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger
    interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which
    appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early
    phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via
    two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3,
    STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an
    event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development.
    In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell
    development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of
    IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it
    inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27
    has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4,
    IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of
    cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on
    T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with
    activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial
    cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II
    transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also
    demonstrates antiviral activity with inhibitory properties on HIV-1 replivation
    Induction: Transiently induced by bacterial lipopolysaccharides (LPS) stimulation in monocytes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ISS--
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
    GO:0045523interleukin-27 receptor binding ISS--
         
    IL27 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL27:
     Decreased Salmonella enterica  

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il27):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    IL27 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il27tm1Cua for IL27

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL27
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL27

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL27
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL27

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL27:
    hsa-mir-335-5p (MIRT017242)

    Block miRNA regulation of human, mouse, rat IL27 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL27
    SwitchGear 3'UTR luciferase reporter plasmidIL27 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IL27
    Predesigned siRNA for gene silencing in human, mouse, rat IL27

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IL27

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    GenScript: all cDNA clones in your preferred vector: IL27 (NM_004843)
    Sino Biological Human cDNA Clone for IL27
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL27

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL27A_HUMAN, Q8NEV9: Secreted. Note=Does not seem to be secreted without coexpression of EBI3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--

    IL27 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL27 About    
    See pathways by source

    SuperPathContained pathways About
    1Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL27
        Th1 Differentiation


    1 BioSystems Pathway for IL27
        IL27-mediated signaling events



        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL27 (see all 8): 
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL27

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IL27 (Q8NEV93 ENSP000003493654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EBI3Q142133, ENSP000002218474I2D: score=1 STRING: ENSP00000221847
    IL27RAQ6UWB13, ENSP000002633794I2D: score=2 STRING: ENSP00000263379
    IL6STP401893, ENSP000003387994I2D: score=1 STRING: ENSP00000338799
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0009617response to bacterium IEA--
    GO:0042129regulation of T cell proliferation ISS--
    GO:0045078positive regulation of interferon-gamma biosynthetic process IDA12734330
    GO:0045087innate immune response IEA--

    IL27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL27 (IL27A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL27 gene: 
    NM_145659.3  

    Unigene Cluster for IL27:

    Interleukin 27
    Hs.528111  [show with all ESTs]
    Unigene Representative Sequence: BC062422
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356897(uc002dqc.3) ENST00000568075
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat IL27
      QuantiFast Probe-based Assays in human, mouse, rat IL27

    Additional mRNA sequence: 

    AY099296.1 BC062422.1 

    1 DOTS entry:

    DT.100011882 

    6 AceView cDNA sequences:

    AY099296 BG548365 BV171801 NM_145659 BC062422 AI085007 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL27 Expression
    About this image

    IL27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528111

    UniProtKB/Swiss-Prot: IL27A_HUMAN, Q8NEV9
    Tissue specificity: Expressed in monocytes and in placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL27 (see all 8): 
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat IL27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL27 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il271 , 5 interleukin 271, 5 82.35(n)1
    79.19(a)1
      7 (69.18 cM)5
    2467791  NM_145636.11  NP_663611.11 
     1265890105 


    ENSEMBL Gene Tree for IL27 (if available)
    TreeFam Gene Tree for IL27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL27 (see all 212)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483914971,2
    C--28510812(+) GCTGGC/TGAGGA 1 -- ut310--------
    rs408371,2
    C,F,A,H--28510845(+) GGTAGA/GGCCTG 1 -- ut3124Minor allele frequency- G:0.37NA PA NS EA CSA WA 2467
    rs2009796141,2
    --28510954(+) GCAGGA/GGGCTA 1 -- ut310--------
    rs2001622631,2
    C--28510969(+) GCCACC/TGATCA 1 -- ut310--------
    rs1929403771,2
    C--28510999(+) GGGAAC/ACCCAA 2 /G syn11Minor allele frequency- A:0.00EU 535
    rs1850550181,2
    C--28511131(+) GCCGGG/TCCCTG 2 G syn10--------
    rs2010366971,2
    C--28511132(+) CCGGGC/ACCTGT 2 /G /V mis11Minor allele frequency- A:0.01EU 127
    rs1474132921,2
    C--28511206(+) TCCTCC/GTCCTC 2 D E mis10--------
    rs1145710901,2
    C,F--28511244(+) CACCTG/ATGAGG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1465312111,2
    C--28511253(+) GGAGAA/GGCCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for IL27 (28510683 - 28523372 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IL27:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509608CNV Insertion20534489
    nsv905689CNV Loss21882294
    nsv833180CNV Loss17160897
    nsv905688CNV Gain21882294
    dgv843e1CNV Complex17122850
    dgv842e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL27
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608273    OMIM disorders: --

    Selected diseases for IL27 (see all 41):    
    About MalaCards
    eosinophilic granulomatosis with polyangiitis    granulomatosis with polyangiitis    visceral leishmaniasis    posterior uveitis
    ischemic heart disease    interstitial lung disease    human t-cell leukemia virus type 1    uveitis
    leishmaniasis    crohn's disease    polymyositis    encephalomyelitis
    ulcerative colitis    bronchiolitis    papilloma    nasopharyngitis
    t-cell leukemia    dermatomyositis    thrombocytopenia    inflammatory bowel disease


    IL27 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for IL27 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    encephalomyelitis 44.8 2 17727629 (1), 15850576 (1)
    lymphoma 2.64 1 15793300 (1)
    tumors 0 1 17476678 (1)

    Genetic Association Database (GAD): IL27
    Human Genome Epidemiology (HuGE) Navigator: IL27 (15 documents)

    Export disorders for IL27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL27 gene, integrated from 10 sources (see all 130):
    (articles sorted by number of sources associating them with IL27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. (PubMed id 17318299)1, 2, 4, 9 Chae S.-C.... Chung H.-T. (J. Hum. Genet. 2007)
    2. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. (PubMed id 12121660)1, 2, 3 Pflanz S....Kastelein R.A. (Immunity 2002)
    3. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. (PubMed id 19686419)1, 4, 9 Li C.S....Chae S.C. (J. Gastroenterol. Hepatol. 2009)
    4. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    5. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)1, 4 Wang K....Hakonarson H. (Hum. Mol. Genet. 2010)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PubMed id 19915574)1, 4 Imielinski M....Hakonarson H. (Nat. Genet. 2009)
    8. Association of variants in the interleukin-27 and interleukin-12 gene with nasopharyngeal carcinoma. (PubMed id 19148899)1, 4 Wei Y.S....Nong H.B. (Mol. Carcinog. 2009)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    10. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 246778 HGNC: 19157 AceView: IL27 Ensembl:ENSG00000197272 euGenes: HUgn246778
    ECgene: IL27 H-InvDB: IL27

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL27 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_27

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL27 gene:
    Search GeneIP for patents involving IL27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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