IL26 Gene(Protein Coding)

Interleukin 26

GCID:: GC12M068201

GIFtS:: 52

Genes Participants

Aliases for IL26 Gene

Interleukin 26 ² ³ ⁵
AK155 ³ ⁴
IL-26 ³ ⁴
Protein AK155 ⁴

External Ids for IL26 Gene

HGNC: 17119
Entrez Gene: 55801
Ensembl: ENSG00000111536
OMIM: 605679
UniProtKB: Q9NPH9

Previous GeneCards Identifiers for IL26 Gene

GC12M068110
GC12M068399
GC12M068311
GC12M066881
GC12M068595
GC12M065646

Export aliases for IL26 gene to outside databases

Summaries for IL26 Gene

Entrez Gene Summary for IL26 Gene

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL26 Gene

IL26 (Interleukin 26) is a Protein Coding gene. Among its related pathways are Th17 Differentiation Pathway and ERK Signaling. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL26 Gene

IL26_HUMAN,Q9NPH9

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

Gene Wiki entry for IL26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL26 Gene

Genomics for IL26 Gene

Regulatory Elements for IL26 Gene

Enhancers for IL26 Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around IL26 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL26 gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for IL26 Gene

Chromosome:: 12

Start:: 68,163,987 bp from pter
End:: 68,225,821 bp from pter

Size:: 61,835 bases
Orientation:: Minus strand

Genomic View for IL26 Gene

Genes around IL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

12q15 by Ensembl
12q15 by Entrez Gene
12q15 by HGNC

IL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for IL26 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL26 Gene

Proteins for IL26 Gene

Protein details for IL26 Gene (UniProtKB/Swiss-Prot)

Protein Symbol:

Q9NPH9-IL26_HUMAN

Recommended name:

Interleukin-26

Protein Accession:

Q9NPH9
Protein attributes for IL26 Gene
Size:

171 amino acids

Molecular mass:

19843 Da
Quaternary structure:
Homodimer.

neXtProt entry for IL26 Gene

Proteomics data for IL26 Gene at MOPED

Protein Expression for IL26 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL26 Gene

Modification sites at PhosphoSitePlus
- Q9NPH9
Modification sites at neXtProt
- NX_Q9NPH9

Other Protein References for IL26 Gene

ENSEMBL proteins:

ENSP00000229134

REFSEQ proteins:

NP_060872.1

Antibody Products

EMD Millipore Complete listing of Mono and Polychlonal Antibodies for IL26

R&D Systems Antibodies for IL26 (IL-26/AK155)

Browse OriGene Antibodies

Novus Biologicals Antibodies for IL26

Abcam antibodies for IL26

Cloud-Clone Corp. Antibodies for IL26
- PAB695Hu01
- MAB695Hu22

Invitrogen Antibodies for IL26

antibodies-online Antibodies for IL26: See all 31

GeneTex Mxd1 antibody for IL26
GeneTex IL26 antibody for IL26

Santa Cruz Biotechnology (SCBT) Antibodies for IL26
- IL-26 (T-12)
- IL-26 (LL07)

Protein Products

Browse Purified and Recombinant Proteins at EMD Millipore

R&D Systems Proteins and Enzymes for IL26 (IL-26/AK155)

Browse Enzo Life Sciences for proteins

OriGene Purified Proteins for IL26
- NM_018402
Search Origene for MassSpec and Protein Over-expression Lysates for IL26
Origene Custom Protein Services for IL26

GenScript Custom Purified and Recombinant Proteins Services for IL26

Novus Biologicals proteins and lysates for IL26

Browse ProSpec Recombinant Proteins

Cloud-Clone Corp. Proteins for IL26
- RPB695Hu01

Search eBioscience for IL26 related proteins

antibodies-online Proteins for IL26: See all 7
Search antibodies-online for peptides

Search GeneTex for Proteins for IL26

Abcam proteins for IL26

Assay Products

Browse Kits and Assays available from EMD Millipore

Browse R&D Systems for biochemical assays

GenScript Custom Assay Services for IL26

Browse Enzo Life Sciences for kits & assays

Cloud-Clone Corp Assay Kits for IL26
- SCB695Hu
- SEB695Hu

Search eBioscience for IL26 related elisas

antibodies-online Kits for IL26: See all 8

Search for Assays for IL26 at Abcam

No data available for DME Specific Peptides for IL26 Gene

Domains & Families for IL26 Gene

Gene Families for IL26 Gene

HGNC:

601 : Interleukins

Protein Domains for IL26 Gene

InterPro:

ProtoNet:

Q9NPH9

Suggested Antigen Peptide Sequences for IL26 Gene

GenScript: Design optimal peptide antigens:

Protein AK155 (IL26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPH9

UniProtKB/Swiss-Prot:

IL26_HUMAN :

Belongs to the IL-10 family.

Family:

Belongs to the IL-10 family.

Function for IL26 Gene

Molecular function for IL26 Gene

UniProtKB/Swiss-Prot Function:

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

IL26_HUMAN,Q9NPH9

UniProtKB/Swiss-Prot Induction:

By Herpesvirus saimiri infection.

IL26_HUMAN,Q9NPH9

Phenotypes for IL26 Gene

GenomeRNAi human phenotypes for IL26:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL26 Gene

Localization for IL26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL26 Gene

Secreted.

Q9NPH9-IL26_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
cytosol	5
extracellular	5
endoplasmic reticulum	1
mitochondrion	1
plasma membrane	1

No data available for Gene Ontology (GO) - Cellular Components for IL26 Gene

Pathways & Interactions for IL26 Gene

SuperPathways for IL26 Gene

More details on SuperPathways for IL26

	Superpath	Contained pathways
1	PEDF Induced Signaling	MIF Mediated Glucocorticoid Regulation .94 MIF Regulation of Innate Immune Cells .94 PEDF Induced Signaling .73 all-trans-Retinoic Acid Signaling in Brain .71 RAR-Gamma-RXR-Alpha Degradation .62 IL-6 Pathway .61	NFAT Signaling and Lymphocyte Interactions .57 PGC1Alpha Pathway .51 STAT3 Pathway .47 Endothelin-1 Signaling Pathway .46 Cytokine-cytokine receptor interaction .43 Glucocorticoid Receptor Signaling .43
2	TGF-Beta Pathway	MAPK Family Pathway .60 TGF-Beta Pathway .60 JAK-STAT Pathway .57	Regulation of eIF4 and p70S6K .43 SOCS Pathway .40
3	Akt Signaling	Akt Signaling .60 p38 Signaling .60	Tec Kinases Signaling .55
4	ERK Signaling	ERK Signaling .61 Rho Family GTPases .61	Molecular Mechanisms of Cancer .51
5	PAK Pathway	Antioxidant Action of Vitamin-C .56	PAK Pathway .56

Pathways by source for IL26 Gene

1 KEGG pathway for IL26 Gene

Cytokine-cytokine receptor interaction

1 R&D Systems pathway for IL26 Gene

Th17 Differentiation Pathway

24 Qiagen pathways for IL26 Gene

Interacting Proteins for IL26 Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000229134%0d%0a9606.ENSP00000362195%0d%0a9606.ENSP00000370979%0d%0a9606.ENSP00000327824%0d%0a9606.ENSP00000274276%0d%0a9606.ENSP00000170630%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: ENSP00000229134 Q9NPH9-IL26_HUMAN for IL26 Gene via STRING I2D

Symbol	External ID(s)	Details
IL20RA	ENSP00000314976 ²⁰ Q9UHF4 ²¹	STRING: ENSP00000314976 I2D: score=1
CNTFR	ENSP00000242338 ²⁰	STRING: ENSP00000242338
CRLF2	ENSP00000370979 ²⁰	STRING: ENSP00000370979
CSF2RA	ENSP00000394227 ²⁰	STRING: ENSP00000394227
CSF2RB	ENSP00000384053 ²⁰	STRING: ENSP00000384053

SIGNOR curated interactions for IL26 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL26 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IBA	--
GO:0006955	immune response	IBA	--
GO:0007267	cell-cell signaling	TAS	10729163
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	18483078
GO:0046427	positive regulation of JAK-STAT cascade	IDA	18483078

Drugs & Compounds for IL26 Gene

No Compound Related Data Available

Drug Products

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL26

Browse compounds at ApexBio

Transcripts for IL26 Gene

mRNA/cDNA for IL26 Gene

(2) REFSEQ mRNAs :

(3) Additional mRNA sequences :

(7) Selected AceView cDNA sequences:

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

ENST00000229134 (uc001stx.2)

Unigene Clusters for IL26 Gene

Interleukin 26:

Hs.272350

Representative Sequences:

AJ251549

CRISPR Products

OriGene CRISPR knockouts for IL26
- KN215491

Santa Cruz Biotechnology (SCBT) CRISPR for IL26

GenScript: Design CRISPR guide RNA sequences for IL26

miRNA Products

Search ViGene Biosciences for IL26

SwitchGear IL26 3' UTR sequence
Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhibitory RNA Products

Origene RNAi, shRNA, and siRNA products in human, mouse, rat for IL26
Browse OriGene Inhibitory RNA Products For IL26

ViGene Biosciences ready-to-package AAV shRNAs for IL26 gene
- SH872711

Search Santa Cruz Biotechnology (SCBT) for IL26 siRNA/shRNA

Clone Products

OriGene clones in human for IL26
OriGene ORF clones in human for IL26
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011538568
- NM_018402

Sino Biological Human cDNA Clone for IL26

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for IL26

Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for IL26 Gene

No ASD Table

Relevant External Links for IL26 Gene

GeneLoc Exon Structure for: IL26
ECgene alternative splicing isoforms for: IL26

Expression for IL26 Gene

mRNA expression in normal human tissues for IL26 Gene

mRNA differential expression in normal tissues according to GTEx for IL26 Gene

This gene is overexpressed in Colon - Sigmoid (x6.0), Esophagus - Mucosa (x4.5), and Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for IL26 Gene

This gene is overexpressed in Heart (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL26 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL26 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for IL26 Gene

SOURCE GeneReport for Unigene cluster for IL26 Gene Hs.272350

mRNA Expression by UniProt/SwissProt for IL26 Gene

Q9NPH9-IL26_HUMAN

Tissue specificity: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohns disease (at protein level).

Protein tissue co-expression partners for IL26 Gene

Primer Products

OriGene qPCR primer pairs for IL26
- HP213065

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL26 Gene

Orthologs for IL26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL26 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
cow (Bos Taurus)	Mammalia	IL26 ³⁵	89.35 (n) 86.39 (a)		782075 NM_001205424.1 NP_001192353.1
dog (Canis familiaris)	Mammalia	IL26 ³⁵	86.59 (n) 81.66 (a)		608923 XM_846075.2 XP_851168.1
dog (Canis familiaris)	Mammalia	IL26 ³⁶	68 (a)	OneToOne	10:10457086-10470987
chimpanzee (Pan troglodytes)	Mammalia	IL26 ³⁵	99.81 (n) 100 (a)		741377 XM_001152032.3 XP_001152032.1
chimpanzee (Pan troglodytes)	Mammalia	IL26 ³⁶	100 (a)	OneToOne	12:67958293-67983263
platypus (Ornithorhynchus anatinus)	Mammalia	IL26 ³⁶	50 (a)	OneToOne	Ultra124:1360072-1362757

Species with no ortholog for IL26:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
chicken (Gallus gallus)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
fruit fly (Drosophila melanogaster)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
lizard (Anolis carolinensis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
mouse (Mus musculus)
oppossum (Monodelphis domestica)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rat (Rattus norvegicus)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea squirt (Ciona intestinalis)
sea squirt (Ciona savignyi)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
tropical clawed frog (Silurana tropicalis)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)
zebrafish (Danio rerio)

Evolution for IL26 Gene

ENSEMBL:: Gene Tree for IL26 (if available)
TreeFam:: Gene Tree for IL26 (if available)

Paralogs for IL26 Gene

No data available for Paralogs for IL26 Gene

Variants for IL26 Gene

Sequence variations from dbSNP and Humsavar for IL26 Gene

SNP ID	Clin	Chr 12 pos	Sequence Context	Type
rs1990664	--	68,172,594(+)	TTTAA(A/G)CCATT	intron-variant
rs7133709	--	68,167,533(+)	GAAAC(C/T)CACCA	intron-variant
rs2080414	--	68,178,037(+)	acaac(A/T)ccaaa	intron-variant
rs2098394	--	68,178,001(+)	acacc(A/C)attat	intron-variant
rs7135373	--	68,164,767(+)	AGTCA(C/T)GGCAT	intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL26 Gene

Variant ID	Type	Subtype	PubMed ID
nsv899221	CNV	Loss	21882294
nsv899222	CNV	Gain	21882294
nsv899223	CNV	Loss	21882294

Variation tolerance for IL26 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 0.54; 11.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL26 Gene

Disorders for IL26 Gene

Relevant External Links for IL26

Genetic Association Database (GAD): IL26
Human Genome Epidemiology (HuGE) Navigator: IL26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:: IL26

No disorders were found for IL26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL26 Gene

Publications for IL26 Gene

Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PMID: 10729163) Knappe A. … Fickenscher H. (J. Virol. 2000) ² ³ ⁴ ⁶⁷
The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PMID: 18483078) Dambacher J. … Brand S. (Gut 2009) ³ ²³
IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PMID: 14764663) Sheikh F. … Kotenko S.V. (J. Immunol. 2004) ³ ²³
The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PMID: 15178681) Hor S. … Fickenscher H. (J. Biol. Chem. 2004) ³ ²³
Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PMID: 14558082) Vandenbroeck K. … Rooney M. (Arthritis Rheum. 2003) ³ ²³