IL26 Gene

Aliases
for IL26 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC12M068110 GC12M068399 GC12M068311 GC12M066881 GC12M065646

Summaries
for IL26 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for IL26 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NC_018923.2  NT_029419.13  

SwitchGear Promoter luciferase reporter plasmid: IL26 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL26

IL26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M068595:  view genomic region     (about GC identifiers)

Proteins
for IL26 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for IL26: NX_Q9NPH9

Explore proteomics data for IL26 at MOPED

Post-translational modifications: 

IL26 Human Recombinant Protein Products:

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	Search GeneTex for Proteins for IL26
	antibodies-online proteins for IL26 (6 products)
	antibodies-online peptides for IL26

IL26 Antibody Products:

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	antibodies-online antibodies for IL26 (27 products)

IL26 Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for IL26 Cloud-Clone Corp. CLIAs for IL26
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	antibodies-online kits for IL26 (4 products)

Domains /
Families
for IL26 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9NPH9

Find genes that share domains with IL26           About GenesLikeMe

Function
for IL26 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for IL26

miRNA Products:		Block miRNA regulation of human, mouse, rat IL26 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate IL26
		SwitchGear 3'UTR luciferase reporter plasmid: IL26 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IL26
		Predesigned siRNA for gene silencing in human, mouse, rat IL26

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IL26

Clone Products:		OriGene clones in human, mouse for IL26 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL26 (NM_018402)
		Sino Biological Human cDNA Clone for IL26
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL26
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL26

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL26
		Browse ESI BIO Cell Lines and PureStem Progenitors for IL26

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26

Localization
for IL26 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	5
extracellular	5
endoplasmic reticulum	1
mitochondrion	1
plasma membrane	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for IL26 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for IL26 About   (see all 7)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	PEDF Induced Signaling	MIF Regulation of Innate Immune Cells 0.94 NFAT Signaling and Lymphocyte Interactions 0.57 MIF Mediated Glucocorticoid Regulation 0.94 PGC1Alpha Pathway 0.51 PEDF Induced Signaling 0.73 STAT3 Pathway 0.47 all-trans-Retinoic Acid Signaling in Brain 0.71 Endothelin-1 Signaling Pathway 0.46
2	TGF-Beta Pathway	TGF-Beta Pathway 0.60 Regulation of eIF4 and p70S6K 0.43 MAPK Family Pathway 0.60 SOCS Pathway 0.40 JAK-STAT Pathway 0.57
3	Akt Signaling	Akt Signaling 0.60 Tec Kinases Signaling 0.55 p38 Signaling 0.60
4	ERK Signaling	ERK Signaling 0.61 Molecular Mechanisms of Cancer 0.51 Rho Family GTPases 0.61
5	PAK Pathway	PAK Pathway 0.56 Antioxidant Action of Vitamin-C 0.56

1 R&D Systems Pathway for IL26

Th17 Differentiation

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL26

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	Tec Kinases Signaling

2 Kegg Pathways  (Kegg details for IL26)

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

Drugs & Compounds
for IL26 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for IL26 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for IL26 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IL26
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IL26
		QuantiTect SYBR Green Assays in human, mouse, rat IL26
		QuantiFast Probe-based Assays in human, mouse, rat IL26

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26

Orthologs
for IL26 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for IL26 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for IL26 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL26 (see all 678)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs49134191,2	C,F,A,H	--	68594776(+)	TTTAAG/TGCAAA	1	--	ds5001		26		NS EA NA WA CSA	2274
rs1498977781,2	C	--	68594796(+)	AGGCCA/GTATTA	1	--	ds5001		0	--	--	--	--
rs1911052981,2		--	68594835(+)	GATGGA/GGTTTT	1	--	ds5001		0	--	--	--	--
rs1425354021,2	C	--	68594845(+)	TAGAC-/GGATTAT	1	--	ds5001		0	--	--	--	--
rs1449017351,2		--	68594879(+)	TGAACC/TGCATT	1	--	ds5001		0	--	--	--	--
rs1490225141,2		--	68594888(+)	TTTAGC/TCTTTC	1	--	ds5001		0	--	--	--	--
rs115710691,2	C,F,H	--	68594956(-)	ATGATG/CGTGAA	1	--	ds5001		16		NS EA NA WA CSA	1372
rs1824068531,2		--	68594959(+)	ACCATC/TATTTG	1	--	ds5001		0	--	--	--	--
rs37418091,2	C,F,A,H	--	68595144(-)	AATAAA/GTTGGG	1	--	ut31		26		NS EA NA CSA WA	3081
rs115710681,2	C,F,H	--	68595187(-)	GCCCAA/G/TTGTGA	2	--	ut31		6		NS EA	512

HapMap Linkage Disequilibrium report for IL26 (68595129 - 68619601 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for IL26:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv899221	CNV	Loss	21882294
nsv899223	CNV	Loss	21882294
nsv899222	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IL26

DNA2.0 Custom Variant and Variant Library Synthesis for IL26

Disorders / Diseases
for IL26 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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3 Novoseek inferred disease relationships for IL26 gene    About this table

Publications
for IL26 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PubMed id 10729163)^{1, 2, 3} Knappe A.... Fickenscher H. (J. Virol. 2000)
2. IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PubMed id 14764663)^{1, 2, 9} Sheikh F.... Kotenko S.V. (J. Immunol. 2004)
3. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PubMed id 15178681)^{1, 2, 9} Hor S.... Fickenscher H. (J. Biol. Chem. 2004)
4. Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PubMed id 14558082)^{1, 4, 9} Vandenbroeck K....Rooney M. (Arthritis Rheum. 2003)
5. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PubMed id 18483078)^{1, 2, 9} Dambacher J.... Brand S. (Gut 2009)
6. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)^{1, 4} Wang K....Hakonarson H. (Hum. Mol. Genet. 2010)
7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
9. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)^{1, 4} McGovern D.P....Seielstad M. (Nat. Genet. 2010)
10. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)^{1, 4} Silverberg M.S....Duerr R.H. (Nat. Genet. 2009)

External Searches for IL26 gene

Genome Databases showing IL26 gene

Other Databases showing IL26 gene

Specialized Databases showing IL26 gene

Products
for IL26 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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