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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL26 Gene

protein-coding GIFtS: 52
GCID: GC12M068595

Interleukin 26

13 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Interleukin 26¹ ²
AK155² ³ ⁵
IL-26² ³
interleukin-26²
Protein AK155³

External Ids:	HGNC: 17119¹	Entrez Gene: 55801²	Ensembl: ENSG00000111536⁷	OMIM: 605679⁵	UniProtKB: Q9NPH9³

Export aliases for IL26 gene to outside databases

Previous GC identifers: GC12M068110 GC12M068399 GC12M068311 GC12M066881 GC12M065646

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL26 Gene:

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded

protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This

protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri.

(provided by RefSeq, Jul 2008)

GeneCards Summary for IL26 Gene:

IL26 (interleukin 26) is a protein-coding gene. Diseases associated with IL26 include febrile seizures, and ulcerative colitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9

Function: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May

play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces

expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases

proliferation of intestinal epithelial cells. Is inhibited by heparin

Gene Wiki entry for IL26 (Interleukin 26) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.2 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL26 gene promoter:
SRF AML1a SRF (504 AA) STAT5A C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL26 promoter sequence

Search SABiosciences Chromatin IP Primers for IL26

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL26

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15

IL26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL26 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M068595: view genomic region (about GC identifiers)

Start:	68,595,129 bp from pter	End:	68,619,601 bp from pter
Size:	24,473 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 (See protein sequence)

Recommended Name: Interleukin-26 precursor

Size: 171 amino acids; 19843 Da

Subunit: Homodimer

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for IL26: NX_Q9NPH9

Explore proteomics data for IL26 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9NPH9

IL26 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_060872.1

ENSEMBL proteins:

ENSP00000229134

Human Recombinant Protein Products for IL26:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL26 (IL-26/AK155)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for IL26 OriGene Custom MassSpec OriGene Custom Protein Services for IL26
	GenScript Custom Purified and Recombinant Proteins Services for IL26
	Novus Biologicals IL26 Proteins Novus Biologicals IL26 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for IL26

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	18483078
GO:0005829	cytosol	IDA	18483078

IL26 for ontologies About GeneDecksing

IL26 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL26
	R&D Systems Antibodies for IL26 (IL-26/AK155)
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	Novus Biologicals IL26 Antibodies
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	ThermoFisher Antibodies for IL26
	LSBio Antibodies in human, mouse, rat for IL26

Assay Products for IL26:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IL26
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for IL26 Cloud-Clone Corp. CLIAs for IL26

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

IL: Interleukins and interleukin receptors

4 InterPro protein domains:

IPR012351 4_helix_cytokine_core

IPR020423 Interleukin-10_CS

IPR009079 4_helix_cytokine-like_core

IPR020443 Interleukin-10/19/20/24

Graphical View of Domain Structure for InterPro Entry Q9NPH9

ProtoNet protein and cluster: Q9NPH9

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9

Similarity: Belongs to the IL-10 family

IL26 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IL26_HUMAN, Q9NPH9

Function: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May

play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces

expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases

proliferation of intestinal epithelial cells. Is inhibited by heparin

Induction: By Herpesvirus saimiri infection

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	18483078

IL26 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IL26:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for IL26

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL26

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL26
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL26
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IL26
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IL26
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for IL26 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL26
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL26

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL26
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL26 About (see all 7)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Mediated Glucocorticoid Regulation	0.94	NFAT Signaling and Lymphocyte Interactions	0.57
MIF Regulation of Innate Immune Cells	0.94	PGC1Alpha Pathway	0.51
PEDF Induced Signaling	0.73	STAT3 Pathway	0.47
all-trans-Retinoic Acid Signaling in Brain	0.71	Endothelin-1 Signaling Pathway	0.46

TGF-Beta Pathway

TGF-Beta Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.40
JAK-STAT Pathway	0.57

Akt Signaling

	Akt Signaling	0.60			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	0.61			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

PAK Pathway

PAK Pathway

0.56

Antioxidant Action of Vitamin-C

0.56

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for IL26

Th17 Differentiation

5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL26 (see all 24)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	Tec Kinases Signaling

2 Kegg Pathways (Kegg details for IL26):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

IL26 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL26

1 Interacting protein for IL26 (Q9NPH9³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL20RA	Q9UHF4³	I2D: score=1

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007267	cell-cell signaling	TAS	10729163
GO:0032874	positive regulation of stress-activated MAPK cascade	IDA	18483078
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	18483078
GO:0046427	positive regulation of JAK-STAT cascade	IDA	18483078
GO:0050680	negative regulation of epithelial cell proliferation	IDA	18483078

IL26 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL26

Search CenterWatch for drugs/clinical trials and news about IL26

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL26 gene:

NM_018402.1

Unigene Cluster for IL26:

Interleukin 26

Hs.272350 [show with all ESTs]

Unigene Representative Sequence: AJ251549

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000229134(uc001stx.1)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL26
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL26
		SwitchGear 3'UTR luciferase reporter plasmid: IL26 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for IL26
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL26
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL26

Clone Products:		OriGene clones in human, mouse for IL26 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL26

Additional mRNA sequence:

AJ251549.1 BC066270.1 BC066271.1

1 DOTS entry:

DT.99928389

7 AceView cDNA sequences:

BC066270 NM_018402 AJ251549 BC066271 CF271979 CA412243 CK130238

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL26 expression in normal human tissues (normalized intensities) IL26 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

IL26 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/0 selected tissues (see all 0) fully expand

PureStem Progenitor ES-198

See IL26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL26

SOURCE GeneReport for Unigene cluster: Hs.272350

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9

Tissue specificity: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells.

Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum

of patients with Crohn's disease (at protein level)

SABiosciences Expression via Pathway-Focused PCR Array including IL26:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IL26
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL26

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for IL26 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	IL26¹	interleukin 26	86.59(n) 81.66(a)		608923 XM_846075.1 XP_851168.1

ENSEMBL Gene Tree for IL26 (if available)
TreeFam Gene Tree for IL26 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4913419^1,2	C,F,A,H	--	68594776(+)	`TTTAAG/TGCAAA`	1	--	ds500¹		26		NS EA NA WA CSA	2274
rs149897778^1,2	C	--	68594796(+)	`AGGCCA/GTATTA`	1	--	ds500¹		0	--	--	--	--
rs191105298^1,2		--	68594835(+)	`GATGGA/GGTTTT`	1	--	ds500¹		0	--	--	--	--
rs142535402^1,2	C	--	68594845(+)	`TAGAC-/GGATTAT`	1	--	ds500¹		0	--	--	--	--
rs144901735^1,2		--	68594879(+)	`TGAACC/TGCATT`	1	--	ds500¹		0	--	--	--	--
rs149022514^1,2		--	68594888(+)	`TTTAGC/TCTTTC`	1	--	ds500¹		0	--	--	--	--
rs11571069^1,2	C,F,H	--	68594956(-)	`ATGATG/CGTGAA`	1	--	ds500¹		16		NS EA NA WA CSA	1372
rs182406853^1,2		--	68594959(+)	`ACCATC/TATTTG`	1	--	ds500¹		0	--	--	--	--
rs3741809^1,2	C,F,A,H	--	68595144(-)	`AATAAA/GTTGGG`	1	--	ut3¹		26		NS EA NA CSA WA	3081
rs11571068^1,2	C,F,H	--	68595187(-)	`GCCCAA/G/TTGTGA`	2	--	ut3¹		6		NS EA	512

HapMap Linkage Disequilibrium report for IL26 (68595129 - 68619601 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for IL26: About this table

Variant ID	Type	Subtype	PubMed ID
nsv899221	CNV	Loss	21882294
nsv899223	CNV	Loss	21882294
nsv899222	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL26

DNA2.0 Custom Variant and Variant Library Synthesis for IL26

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL26 for disorders           About GeneDecksing

OMIM gene information: 605679    OMIM disorders: --

13 diseases for IL26:    About MalaCards

febrile seizures ulcerative colitis bronchiolitis crohn's disease

inflammatory bowel disease rheumatoid arthritis psoriasis multiple sclerosis

type 1 diabetes arthritis hepatitis b asthma

hepatitis

3 Novoseek inferred disease relationships for IL26 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	26.3	3	14558082 (1)
melanoma	26.1	7	12370360 (1), 15557163 (1), 11564763 (1), 11929132 (1)
tumors	0	3	15120646 (1), 19589459 (1)

Genetic Association Database (GAD): IL26
Human Genome Epidemiology (HuGE) Navigator: IL26 (10 documents)

Export disorders for IL26 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL26 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with IL26)

Utopia: connect your pdf to the dynamic
world of online information

Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PubMed id 10729163)^{1, 2, 3} Knappe A.... Fickenscher H. (2000)
IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PubMed id 14764663)^{1, 2, 9} Sheikh F.... Kotenko S.V. (2004)
The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PubMed id 15178681)^{1, 2, 9} Hor S.... Fickenscher H. (2004)
Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PubMed id 14558082)^{1, 4, 9} Vandenbroeck K....Rooney M. (2003)
The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PubMed id 18483078)^{1, 2, 9} Dambacher J.... Brand S. (2009)
Comparative genetic analysis of inflammatory bowel di sease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)^{1, 4} Wang K....Hakonarson H. (2010)
Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)^{1, 4} McGovern D.P....Weersma R.K. (2010)
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)^{1, 4} Silverberg M.S....Duerr R.H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55801	HGNC: 17119	AceView: IL26	Ensembl:ENSG00000111536	euGenes: HUgn55801
ECgene: IL26	Kegg: 55801	H-InvDB: IL26

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL26	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_26
SeattleSNPs	http://pga.gs.washington.edu/data/il26/

Intellectual Property for IL26 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL26 gene:
Search GeneIP for patents involving IL26

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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IL26 Gene

Interleukin 26

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