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Set Analyses:

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IL26 Gene

protein-coding GIFtS: 51
GCID: GC12M068595

Interleukin 26

Pneumococci & Pneumococcal Diseases Congress

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Interleukin 26¹ ²
AK155² ³ ⁵
IL-26² ³
interleukin-26²
Protein AK155³

External Ids:	HGNC: 17119¹	Entrez Gene: 55801²	Ensembl: ENSG00000111536⁷	OMIM: 605679⁵	UniProtKB: Q9NPH9³

Export aliases for IL26 gene to outside databases

Previous GC identifers: GC12M068110 GC12M068399 GC12M068311 GC12M066881 GC12M065646

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL26 Gene:

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The

encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a

homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by

herpesvirus samimiri. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL26 Gene:

IL26 (interleukin 26) is a protein-coding gene. Diseases associated with IL26 include febrile seizures, and ulcerative colitis. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9

Function: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function.

May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces

expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases

proliferation of intestinal epithelial cells. Is inhibited by heparin

Gene Wiki entry for IL26 (Interleukin 26) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000012.12 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the IL26 gene promoter:
SRF AML1a SRF (504 AA) STAT5A C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL26 promoter sequence

Search Chromatin IP Primers for IL26

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL26

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15

IL26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL26 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M068595: view genomic region (about GC identifiers)

Start:	68,595,129 bp from pter	End:	68,619,601 bp from pter
Size:	24,473 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 (See protein sequence)

Recommended Name: Interleukin-26 precursor

Size: 171 amino acids; 19843 Da

Subunit: Homodimer

Explore the universe of human proteins at neXtProt for IL26: NX_Q9NPH9

Explore proteomics data for IL26 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See IL26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060872.1

ENSEMBL proteins:

ENSP00000229134

IL26 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL26 (IL-26/AK155)
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for IL26 OriGene Custom MassSpec OriGene Custom Protein Services for IL26
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	Novus Biologicals IL26 Proteins Novus Biologicals IL26 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for IL26

IL26 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL26
	R&D Systems Antibodies for IL26 (IL-26/AK155)
	OriGene Antibodies for IL26 OriGene Custom Antibody Services for IL26
	Novus Biologicals IL26 Antibodies
	Abcam antibodies for IL26
	Cloud-Clone Corp. Antibodies for IL26
	ThermoFisher Antibodies for IL26
	LSBio Antibodies in human, mouse, rat for IL26

IL26 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IL26
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for IL26 Cloud-Clone Corp. CLIAs for IL26

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

IL: Interleukins and interleukin receptors

5 InterPro protein domains:

IPR012351 4_helix_cytokine_core

IPR020423 IL-10_CS

IPR009079 4_helix_cytokine-like_core

IPR028152 IL-26

IPR020443 IL-10/19/20/24/26_fam

Graphical View of Domain Structure for InterPro Entry Q9NPH9

ProtoNet protein and cluster: Q9NPH9

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9

Similarity: Belongs to the IL-10 family

IL26 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: IL26_HUMAN, Q9NPH9

Function: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function.

May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces

expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases

proliferation of intestinal epithelial cells. Is inhibited by heparin

Induction: By Herpesvirus saimiri infection

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	18483078

IL26 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IL26:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL26

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL26

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL26

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL26

miRNA Products:		Block miRNA regulation of human, mouse, rat IL26 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate IL26
		SwitchGear 3'UTR luciferase reporter plasmid: IL26 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IL26
		Predesigned siRNA for gene silencing in human, mouse, rat IL26

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL26

Clone Products:		OriGene clones in human, mouse for IL26 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL26

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL26
		Browse ESI BIO Cell Lines and PureStem Progenitors for IL26

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

IL26_HUMAN, Q9NPH9: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	5
extracellular	5
endoplasmic reticulum	1
mitochondrion	1
plasma membrane	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	18483078
GO:0005829	cytosol	IDA	18483078

IL26 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL26 About (see all 7)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

PEDF Induced Signaling

MIF Regulation of Innate Immune Cells	0.94	NFAT Signaling and Lymphocyte Interactions	0.57
MIF Mediated Glucocorticoid Regulation	0.94	PGC1Alpha Pathway	0.51
PEDF Induced Signaling	0.73	STAT3 Pathway	0.47
all-trans-Retinoic Acid Signaling in Brain	0.71	Endothelin-1 Signaling Pathway	0.46

TGF-Beta Pathway

TGF-Beta Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.40
JAK-STAT Pathway	0.57

Akt Signaling

	Akt Signaling	0.60			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

ERK Signaling

	Rho Family GTPases	0.61			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

PAK Pathway

PAK Pathway

0.56

Antioxidant Action of Vitamin-C

0.56

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for IL26

Th17 Differentiation

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL26 (see all 24)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	Tec Kinases Signaling

2 Kegg Pathways (Kegg details for IL26):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

IL26 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including IL26:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for IL26

1 Interacting protein for IL26 (Q9NPH9³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL20RA	Q9UHF4³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007267	cell-cell signaling	TAS	10729163
GO:0032874	positive regulation of stress-activated MAPK cascade	IDA	18483078
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	18483078
GO:0046427	positive regulation of JAK-STAT cascade	IDA	18483078
GO:0050680	negative regulation of epithelial cell proliferation	IDA	18483078

IL26 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for IL26

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IL26 gene:

NM_018402.1

Unigene Cluster for IL26:

Interleukin 26

Hs.272350 [show with all ESTs]

Unigene Representative Sequence: AJ251549

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000229134(uc001stx.1)

miRNA Products:		Block miRNA regulation of human, mouse, rat IL26 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate IL26
		SwitchGear 3'UTR luciferase reporter plasmid: IL26 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IL26
		Predesigned siRNA for gene silencing in human, mouse, rat IL26

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		GenScript: all cDNA clones in your preferred vector: IL26 (NM_018402)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL26

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IL26
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat IL26
		QuantiTect SYBR Green Assays in human, mouse, rat IL26
		QuantiFast Probe-based Assays in human, mouse, rat IL26

Additional mRNA sequence:

AJ251549.1 BC066270.1 BC066271.1

1 DOTS entry:

DT.99928389

7 AceView cDNA sequences:

BC066270 AJ251549 NM_018402 CF271979 CA412243 BC066271 CK130238

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

IL26 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

IL26 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.272350

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9

Tissue specificity: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells.

Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in

serum of patients with Crohn's disease (at protein level)

Pathway & Disease-focused RT² Profiler PCR Array including IL26:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for IL26
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat IL26
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		QuantiFast Probe-based Assays in human, mouse, rat IL26

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for IL26 gene from Selected species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	IL26¹	interleukin 26	86.59(n) 81.66(a)		608923 XM_846075.2 XP_851168.1

ENSEMBL Gene Tree for IL26 (if available)
TreeFam Gene Tree for IL26 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4913419^1,2	C,F,A,H	--	68594776(+)	`TTTAAG/TGCAAA`	1	--	ds500¹		26		NS EA NA WA CSA	2274
rs149897778^1,2	C	--	68594796(+)	`AGGCCA/GTATTA`	1	--	ds500¹		0	--	--	--	--
rs191105298^1,2		--	68594835(+)	`GATGGA/GGTTTT`	1	--	ds500¹		0	--	--	--	--
rs142535402^1,2	C	--	68594845(+)	`TAGAC-/GGATTAT`	1	--	ds500¹		0	--	--	--	--
rs144901735^1,2		--	68594879(+)	`TGAACC/TGCATT`	1	--	ds500¹		0	--	--	--	--
rs149022514^1,2		--	68594888(+)	`TTTAGC/TCTTTC`	1	--	ds500¹		0	--	--	--	--
rs11571069^1,2	C,F,H	--	68594956(-)	`ATGATG/CGTGAA`	1	--	ds500¹		16		NS EA NA WA CSA	1372
rs182406853^1,2		--	68594959(+)	`ACCATC/TATTTG`	1	--	ds500¹		0	--	--	--	--
rs3741809^1,2	C,F,A,H	--	68595144(-)	`AATAAA/GTTGGG`	1	--	ut3¹		26		NS EA NA CSA WA	3081
rs11571068^1,2	C,F,H	--	68595187(-)	`GCCCAA/G/TTGTGA`	2	--	ut3¹		6		NS EA	512

HapMap Linkage Disequilibrium report for IL26 (68595129 - 68619601 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for IL26: About this table

Variant ID	Type	Subtype	PubMed ID
nsv899221	CNV	Loss	21882294
nsv899223	CNV	Loss	21882294
nsv899222	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing IL26

DNA2.0 Custom Variant and Variant Library Synthesis for IL26

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605679 OMIM disorders: --

14 diseases for IL26: About MalaCards

febrile seizures ulcerative colitis bronchiolitis rheumatoid arthritis

crohn's disease inflammatory bowel disease psoriasis multiple sclerosis

type 1 diabetes arthritis asthma hepatitis b

hepatitis melanoma

IL26 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

3 Novoseek inferred disease relationships for IL26 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rheumatoid arthritis	26.3	3	14558082 (1)
melanoma	26.1	7	12370360 (1), 15557163 (1), 11564763 (1), 11929132 (1)
tumors	0	3	15120646 (1), 19589459 (1)

Genetic Association Database (GAD): IL26
Human Genome Epidemiology (HuGE) Navigator: IL26 (10 documents)

Export disorders for IL26 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL26 gene, integrated from 10 sources (see all 51):
(articles sorted by number of sources associating them with IL26)

Utopia: connect your pdf to the dynamic
world of online information

Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PubMed id 10729163)^{1, 2, 3} Knappe A.... Fickenscher H. (J. Virol. 2000)
IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PubMed id 14764663)^{1, 2, 9} Sheikh F.... Kotenko S.V. (J. Immunol. 2004)
The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PubMed id 15178681)^{1, 2, 9} Hor S.... Fickenscher H. (J. Biol. Chem. 2004)
Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PubMed id 14558082)^{1, 4, 9} Vandenbroeck K....Rooney M. (Arthritis Rheum. 2003)
The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PubMed id 18483078)^{1, 2, 9} Dambacher J.... Brand S. (Gut 2009)
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)^{1, 4} Wang K....Hakonarson H. (Hum. Mol. Genet. 2010)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)^{1, 4} McGovern D.P....Seielstad M. (Nat. Genet. 2010)
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)^{1, 4} Silverberg M.S....Duerr R.H. (Nat. Genet. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55801	HGNC: 17119	AceView: IL26	Ensembl:ENSG00000111536	euGenes: HUgn55801
ECgene: IL26	Kegg: 55801	H-InvDB: IL26

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IL26	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_26
SeattleSNPs	http://pga.gs.washington.edu/data/il26/

Intellectual Property for IL26 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL26 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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IL26 Gene

Interleukin 26

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IL26 Gene

Interleukin 26

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