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Aliases for IL26 Gene

Aliases for IL26 Gene

  • Interleukin 26 2 3
  • AK155 3 4 6
  • IL-26 3 4
  • Interleukin-26 3
  • Protein AK155 4

External Ids for IL26 Gene

Summaries for IL26 Gene

Entrez Gene Summary for IL26 Gene

  • This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL26 Gene

IL26 (Interleukin 26) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL26 Gene

  • May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

Gene Wiki entry for IL26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL26 Gene

Genomics for IL26 Gene

Genomic Location for IL26 Gene

Start:
68,201,349 bp from pter
End:
68,225,821 bp from pter
Size:
24,473 bases
Orientation:
Minus strand

Genomic View for IL26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL26 Gene

Regulatory Elements for IL26 Gene

Proteins for IL26 Gene

  • Protein details for IL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH9-IL26_HUMAN
    Recommended name:
    Interleukin-26
    Protein Accession:
    Q9NPH9
    Secondary Accessions:

    Protein attributes for IL26 Gene

    Size:
    171 amino acids
    Molecular mass:
    19843 Da
    Quaternary structure:
    • Homodimer

neXtProt entry for IL26 Gene

Proteomics data for IL26 Gene at MOPED

Post-translational modifications for IL26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL26 Gene

Domains for IL26 Gene

Gene Families for IL26 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

UniProtKB/Swiss-Prot:

IL26_HUMAN
Family:
  • Belongs to the IL-10 family.:
    • Q9NPH9
genes like me logo Genes that share domains with IL26: view

Function for IL26 Gene

Molecular function for IL26 Gene

UniProtKB/Swiss-Prot Function: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
UniProtKB/Swiss-Prot Induction: By Herpesvirus saimiri infection

Gene Ontology (GO) - Molecular Function for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 18483078
genes like me logo Genes that share ontologies with IL26: view

Phenotypes for IL26 Gene

GenomeRNAi human phenotypes for IL26:
genes like me logo Genes that share phenotypes with IL26: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL26 Gene

Localization for IL26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL26 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL26 Gene COMPARTMENTS Subcellular localization image for IL26 gene
Compartment Confidence
cytosol 5
extracellular 5
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18483078
GO:0005829 cytosol IDA 18483078
genes like me logo Genes that share ontologies with IL26: view

Pathways for IL26 Gene

genes like me logo Genes that share pathways with IL26: view

Pathways by source for IL26 Gene

Gene Ontology (GO) - Biological Process for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007267 cell-cell signaling TAS 10729163
GO:0032874 positive regulation of stress-activated MAPK cascade IDA 18483078
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 18483078
genes like me logo Genes that share ontologies with IL26: view

Transcripts for IL26 Gene

mRNA/cDNA for IL26 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL26 Gene

Interleukin 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL26 Gene

No ASD Table

Relevant External Links for IL26 Gene

GeneLoc Exon Structure for
IL26
ECgene alternative splicing isoforms for
IL26

Expression for IL26 Gene

mRNA expression in normal human tissues for IL26 Gene

mRNA differential expression in normal tissues according to GTEx for IL26 Gene

This gene is overexpressed in Colon - Sigmoid (6.0), Esophagus - Mucosa (4.5), and Small Intestine - Terminal Ileum (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL26 Gene

SOURCE GeneReport for Unigene cluster for IL26 Gene Hs.272350

mRNA Expression by UniProt/SwissProt for IL26 Gene

Q9NPH9-IL26_HUMAN
Tissue specificity: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohns disease (at protein level).
genes like me logo Genes that share expressions with IL26: view

Orthologs for IL26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL26 36
  • 99.81 (n)
  • 100 (a)
IL26 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL26 36
  • 89.35 (n)
  • 86.39 (a)
dog
(Canis familiaris)
Mammalia IL26 36
  • 86.59 (n)
  • 81.66 (a)
IL26 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL26 37
  • 50 (a)
OneToOne
Species with no ortholog for IL26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL26 Gene

ENSEMBL:
Gene Tree for IL26 (if available)
TreeFam:
Gene Tree for IL26 (if available)

Paralogs for IL26 Gene

No data available for Paralogs for IL26 Gene

Variants for IL26 Gene

Sequence variations from dbSNP and Humsavar for IL26 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs741344 -- 68,203,306(+) ATAAA(A/G)GAAAA intron-variant
rs741345 -- 68,203,492(+) TGCTC(A/G)TGACA intron-variant
rs759489 -- 68,207,936(+) GATAC(A/G)CATCT intron-variant
rs759490 -- 68,208,319(+) AGAGC(A/G)CAGAG intron-variant
rs768049 -- 68,202,331(-) TCATA(G/T)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL26 Gene

Variant ID Type Subtype PubMed ID
nsv899221 CNV Loss 21882294
nsv899222 CNV Gain 21882294
nsv899223 CNV Loss 21882294

Relevant External Links for IL26 Gene

HapMap Linkage Disequilibrium report
IL26

Disorders for IL26 Gene

(3) Novoseek inferred disease relationships for IL26 Gene

Disease -log(P) Hits PubMed IDs
rheumatoid arthritis 26.3 1
melanoma 26.1 4
tumors 0 2

Relevant External Links for IL26

Genetic Association Database (GAD)
IL26
Human Genome Epidemiology (HuGE) Navigator
IL26
genes like me logo Genes that share disorders with IL26: view

No data available for UniProtKB/Swiss-Prot for IL26 Gene

Publications for IL26 Gene

  1. IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PMID: 14764663) Sheikh F. … Kotenko S.V. (J. Immunol. 2004) 3 4 23
  2. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PMID: 15178681) Hor S. … Fickenscher H. (J. Biol. Chem. 2004) 3 4 23
  3. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PMID: 18483078) Dambacher J. … Brand S. (Gut 2009) 3 4 23
  4. Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PMID: 14558082) Vandenbroeck K. … Rooney M. (Arthritis Rheum. 2003) 3 23 49
  5. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PMID: 10729163) Knappe A. … Fickenscher H. (J. Virol. 2000) 2 3 4

Products for IL26 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IL26
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IL26
    • Block miRNA regulation of IL26 using miScript Target Protectors

    Sources for IL26 Gene

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