IL26 Gene
protein-coding GIFtS : 53
GCID: GC12 M068595
interleukin 26
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Aliasesfor IL26 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Interleukin 26 1 2 AK1551 2 3 5 IL-261 2 3 Interleukin-261 Protein AK1553
Export aliases for IL26 gene to outside databases Previous GC identifers: GC12M068110 GC12M068399 GC12M068311 GC12M066881 GC12M065646
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Summariesfor IL26 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for IL26 : This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 Function : May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. Mayplay a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin Gene Wiki entry for IL26 (Interleukin 26)
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Genomic Viewsfor IL26 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IL26 gene promoter: SRF AML1a SRF (504 AA) STAT5A C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for IL26 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL26
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15 IL26 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M068595: view genomic region
(about GC identifiers )
Start:
68,595,129 bp from pter
End:
68,619,601 bp from pter
Size:
24,473 bases
Orientation:
minus strand
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Proteinsfor IL26 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 (See
protein sequence )Recommended Name: Interleukin-26 precursor Size : 171 amino acids; 19843 Da
Subunit : Homodimer
Subcellular location : SecretedExplore the universe of human proteins at neXtProt for IL26: NX_Q9NPH9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NPH9 IL26 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060872.1 ENSEMBL proteins: ENSP00000229134 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
IL26 for ontologies About GeneDecksing IL26 Antibody Products: Assay Products for IL26:
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Protein
Domains / Familiesfor IL26 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IL26 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NPH9 ProtoNet protein and cluster: Q9NPH9
UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 Similarity : Belongs to the IL-10 family
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Functionfor IL26 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 Function : May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. Mayplay a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin Induction : By Herpesvirus saimiri infection
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IL26 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IL26OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IL26 (NM_018402 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL26 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IL26
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
IL26 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for IL26 :
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Pathways & Interactionsfor IL26 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/7 super-pathways (see all 7 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 PEDF Induced Signaling 2 TGF-Beta Pathway 3 Akt Signaling 4 Rho Family GTPases 5 PAK Pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 R&D Systems Pathway for IL26 5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL26 (see all 24 )2
Kegg Pathways (Kegg details for IL26) :
IL26 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL26 1 Interacting protein for IL26 (Q9NPH9 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
IL26 for ontologies About GeneDecksing
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Drugs & Compoundsfor IL26 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IL26 Search CenterWatch for drugs/clinical trials and news about IL26
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Transcriptsfor IL26 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IL26 gene: NM_018402.1 Unigene Cluster for IL26:
Interleukin 26 Hs.272350 [show with all ESTs ] Unigene Representative Sequence: AJ251549 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000229134 (uc001stx.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IL26 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IL26OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IL26 (NM_018402 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL26 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IL26
Additional cDNA sequence: AJ251549.1 BC066270.1 BC066271.1
1 DOTS entry : DT.99928389
7 AceView cDNA sequences :
BC066270 NM_018402 AJ251549 CA412243 CF271979 BC066271 CK130238 GeneLoc Exon Structure
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Expression for IL26 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IL26 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image IL26 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category PureStem™ progenitor T42 (Embryonic Progenitor Cell)PureStem™ progenitor T36 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See IL26 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IL26 SOURCE GeneReport for Unigene cluster: Hs.272350 UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 Tissue specificity : Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells.Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level) SABiosciences Expression via Pathway-Focused PCR Array including IL26 : Inflammatory Response & Autoimmunity 384HT in human mouse rat
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IL26Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat IL26 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IL26 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IL26 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26
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Orthologsfor IL26 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for IL26 gene from 1/5 species (see all 5 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
IL266
Uncharacterized protein
43(a)
1 ↔ 1
1(36953385-36960507)
Species with no ortholog for IL26 ENSEMBL Gene Tree for IL26 (if available)TreeFam Gene Tree for IL26 (if available)
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Paralogsfor IL26 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor IL26 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IL26 (68595129 - 68619601 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for IL26: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IL26
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Disorders
/ Diseasesfor IL26 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IL26 for disorders About GeneDecksing
OMIM gene information: 605679
OMIM disorders : --13 diseases for IL26 : About MalaCards febrile seizures inflammatory bowel disease rheumatoid arthritis multiple sclerosis ulcerative colitis bronchiolitis seizures crohn's disease hepatitis b arthritis psoriasis asthma hepatitis 3 Novoseek disease relationships for IL26 gene About this table
Genetic Association Database (GAD): IL26 Human Genome Epidemiology (HuGE) Navigator: IL26 (10 documents) Export disorders for IL26 gene to outside databases
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Publicationsfor IL26 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IL26 gene, integrated from 9 sources (see all 46 ): (articles sorted by number of sources associating them with IL26) Utopia : connect your pdf to the dynamic world of online information
Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PubMed id 10729163) 1 , 2 , 3 Knappe A.... Fickenscher H. (2000) IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PubMed id 14764663) 1 , 2 , 9 Sheikh F.... Kotenko S.V. (2004) The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PubMed id 15178681) 1 , 2 , 9 Hor S.... Fickenscher H. (2004) Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PubMed id 14558082) 1 , 4, 9 Vandenbroeck K....Rooney M. (2003) The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PubMed id 18483078) 1 , 2 , 9 Dambacher J.... Brand S. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15). (PubMed id 11528524) 1 , 3 Goris A....Vandenbroeck K. (2001) Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element. (PubMed id 22622197) 1 Collins P.L....Aune T.M. (2012) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633) 1 Anderson C.A....Rioux J.D. (2011)
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External Searches for IL26 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IL26 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IL26 gene
(According to HUGE )
About This Section --
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Specialized Databases showing IL26 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IL26 Pharmacogenomics, SNPs, Pathways Wikipedia http://en.wikipedia.org/wiki/Interleukin_26 SeattleSNPs http://pga.gs.washington.edu/data/il26/
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About This Section Patent Information for IL26 gene: Search GeneIP for patents involving IL26 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IL26 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for IL26 OriGene shRNA RFP for IL26 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IL26 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IL26 OriGene Protein Over-expression Lysate for IL26 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IL26 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IL26 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IL26 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IL26 OriGene Custom Protein Services for IL26 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL26 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IL26 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL26 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IL26 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IL26 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IL26
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IL26 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26
ThermoFisher Antibodies for IL26
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IL26
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Aliases for IL26
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Disorders / Diseases for IL26
Domains / Families for IL26
Drugs / Compounds for IL26
Expression for IL26
Function for IL26
Genomic Views for IL26
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Orthologs for IL26
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Pathways / Interactions for IL26
Products for IL26
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