Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL26 Gene

protein-coding   GIFtS: 52
GCID: GC12M068595

Interleukin 26
  See related diseases
at
MalaCards
 

Aliases
for IL26 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Interleukin 261 2
AK1552 3 5
IL-262 3
interleukin-262
Protein AK1553

External Ids:    HGNC: 171191   Entrez Gene: 558012   Ensembl: ENSG000001115367   OMIM: 6056795   UniProtKB: Q9NPH93   

Export aliases for IL26 gene to outside databases

Previous GC identifers: GC12M068110 GC12M068399 GC12M068311 GC12M066881 GC12M065646


Summaries
for IL26 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL26 Gene:
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The
encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a
homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by
herpesvirus samimiri. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL26 Gene: 
IL26 (interleukin 26) is a protein-coding gene. Diseases associated with IL26 include febrile seizures, and ulcerative colitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9
Function: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function.
May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces
expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases
proliferation of intestinal epithelial cells. Is inhibited by heparin

Gene Wiki entry for IL26 (Interleukin 26) Gene


Genomic Views
for IL26 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL26 gene promoter:
         SRF   AML1a   SRF (504 AA)   STAT5A   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL26 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

IL26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL26 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M068595:  view genomic region     (about GC identifiers)

Start:
 68,595,129 bp from pter      End:
 68,619,601 bp from pter
Size:
 24,473 bases      Orientation:
 minus strand

Proteins
for IL26 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9 (See protein sequence)
Recommended Name: Interleukin-26 precursor  
Size: 171 amino acids; 19843 Da
Subunit: Homodimer
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for IL26: NX_Q9NPH9

Explore proteomics data for IL26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPH9

    • IL26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL26 Protein Expression
    REFSEQ proteins: NP_060872.1  
    ENSEMBL proteins: 
     ENSP00000229134  

    Human Recombinant Protein Products for IL26: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL26 (IL-26/AK155)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL26
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IL26
    GenScript Custom Purified and Recombinant Proteins Services for IL26
    Novus Biologicals IL26 Proteins
    Novus Biologicals IL26 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IL26 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA18483078
    GO:0005829cytosol IDA18483078

    IL26 for ontologies           About GeneDecksing



    IL26 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL26
    R&D Systems Antibodies for IL26 (IL-26/AK155)
    OriGene Antibodies for IL26
    OriGene Custom Antibody Services for IL26
    GenScript Custom Superior Antibodies Services for IL26
    Novus Biologicals IL26 Antibodies
    Abcam antibodies for IL26
    Cloud-Clone Corp. Antibodies for IL26 
    ThermoFisher Antibodies for IL26
    LSBio Antibodies in human, mouse, rat for IL26 

    Assay Products for IL26: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL26
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IL26
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL26 
    Cloud-Clone Corp. CLIAs for IL26

    Protein Domains /
    Families
    for IL26 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR020423 Interleukin-10_CS
     IPR009079 4_helix_cytokine-like_core
     IPR020443 Interleukin-10/19/20/24

    Graphical View of Domain Structure for InterPro Entry Q9NPH9

    ProtoNet protein and cluster: Q9NPH9

    UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9
    Similarity: Belongs to the IL-10 family


    IL26 for domains           About GeneDecksing


    Function
    for IL26 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL26_HUMAN, Q9NPH9
    Function: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function.
    May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces
    expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases
    proliferation of intestinal epithelial cells. Is inhibited by heparin
    Induction: By Herpesvirus saimiri infection

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA18483078
         
    IL26 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL26:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL26 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL26 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL26 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL26
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL26
    SwitchGear 3'UTR luciferase reporter plasmid: IL26 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL26

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IL26
    Sirion Biotech Customized adenovirus for overexpression of IL26

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL26 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL26 (NM_018402)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL26
    Sirion Biotech Customized lentivirus for stable overexpression of IL26 
                         Customized lentivirus expression plasmids for stable overexpression of IL26 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IL26
    Search LifeMap BioReagents cell lines for IL26
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26


    Pathways & Interactions
    for IL26 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL26 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    		MIF Mediated Glucocorticoid Regulation0.94
    		NFAT Signaling and Lymphocyte Interactions0.57
    		MIF Regulation of Innate Immune Cells0.94
    		PGC1Alpha Pathway0.51
    		PEDF Induced Signaling0.73
    		STAT3 Pathway0.47
    		all-trans-Retinoic Acid Signaling in Brain0.71
    		Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    		TGF-Beta Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		MAPK Family Pathway0.60
    		SOCS Pathway0.40
    		JAK-STAT Pathway0.57
    3Akt Signaling
    		Akt Signaling0.60
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    4Rho Family GTPases
    		Rho Family GTPases0.61
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    5PAK Pathway
    		PAK Pathway0.56
    		Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL26
        Th17 Differentiation

    5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL26 (see all 24)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling


    2         Kegg Pathways  (Kegg details for IL26):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IL26 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL26

    1 Interacting protein for IL26 (Q9NPH93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL20RAQ9UHF43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS10729163
    GO:0032874positive regulation of stress-activated MAPK cascade IDA18483078
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA18483078
    GO:0046427positive regulation of JAK-STAT cascade IDA18483078
    GO:0050680negative regulation of epithelial cell proliferation IDA18483078

    IL26 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL26 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL26

    Search CenterWatch for drugs/clinical trials and news about IL26

    Transcripts
    for IL26 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL26 gene: 
    NM_018402.1  

    Unigene Cluster for IL26:

    Interleukin 26
    Hs.272350  [show with all ESTs]
    Unigene Representative Sequence: AJ251549
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229134(uc001stx.1)
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL26
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL26
    SwitchGear 3'UTR luciferase reporter plasmid: IL26 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL26
    Clone
    Products:             		 OriGene clones in human, mouse for IL26 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL26 (NM_018402)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL26
    Sirion Biotech Customized lentivirus for stable overexpression of IL26 
                         Customized lentivirus expression plasmids for stable overexpression of IL26 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for IL26
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL26
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL26
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL26

    Additional mRNA sequence: 

    AJ251549.1 BC066270.1 BC066271.1 

    1 DOTS entry:

    DT.99928389 

    7 AceView cDNA sequences:

    BC066270 NM_018402 AJ251549 BC066271 CF271979 CA412243 CK130238 

    GeneLoc Exon Structure


    Expression
    for IL26 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL26 expression in normal human tissues (normalized intensities)      IL26 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL26 Expression
    About this image


    IL26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Uncategorized (Uncategorized)
             PureStem Progenitor ES-198

    See IL26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL26

    SOURCE GeneReport for Unigene cluster: Hs.272350

    UniProtKB/Swiss-Prot: IL26_HUMAN, Q9NPH9
    Tissue specificity: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells.
    Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in
    serum of patients with Crohn's disease (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including IL26: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for IL26
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL26
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL26
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL26
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26

    Orthologs
    for IL26 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of mammals.

    Orthologs for IL26 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    dog
    (Canis familiaris)    		 Mammalia IL261 interleukin 26 86.59(n)
    81.66(a)    		   608923  XM_846075.1  XP_851168.1 


    ENSEMBL Gene Tree for IL26 (if available)
    TreeFam Gene Tree for IL26 (if available)

    Paralogs
    for IL26 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for IL26 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/678 SNPs in IL26 are shown (see all 678)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs49134191,2
    		C,F,A,H--68594776(+) TTTAAG/TGCAAA 1 -- ds500126Minor allele frequency- T:0.18NS EA NA WA CSA 2274
    rs1498977781,2
    		C--68594796(+) AGGCCA/GTATTA 1 -- ds50010--------
    rs1911052981,2
    		--68594835(+) GATGGA/GGTTTT 1 -- ds50010--------
    rs1425354021,2
    		C--68594845(+) TAGAC-/GGATTAT 1 -- ds50010--------
    rs1449017351,2
    		--68594879(+) TGAACC/TGCATT 1 -- ds50010--------
    rs1490225141,2
    		--68594888(+) TTTAGC/TCTTTC 1 -- ds50010--------
    rs115710691,2
    		C,F,H--68594956(-) ATGATG/CGTGAA 1 -- ds500116Minor allele frequency- C:0.04NS EA NA WA CSA 1372
    rs1824068531,2
    		--68594959(+) ACCATC/TATTTG 1 -- ds50010--------
    rs37418091,2
    		C,F,A,H--68595144(-) AATAAA/GTTGGG 1 -- ut3126Minor allele frequency- G:0.24NS EA NA CSA WA 3081
    rs115710681,2
    		C,F,H--68595187(-) GCCCAA/G/TTGTGA 2 -- ut316NS EA 512

    HapMap Linkage Disequilibrium report for IL26 (68595129 - 68619601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IL26:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899221CNV Loss21882294
    nsv899223CNV Loss21882294
    nsv899222CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL26
    DNA2.0 Custom Variant and Variant Library Synthesis for IL26

    Disorders / Diseases
    for IL26 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 605679    OMIM disorders: --

    13 diseases for IL26:    About MalaCards
    febrile seizures    ulcerative colitis    bronchiolitis    crohn's disease
    inflammatory bowel disease    rheumatoid arthritis    psoriasis    multiple sclerosis
    type 1 diabetes    arthritis    hepatitis b    asthma
    hepatitis


    IL26 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for IL26 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 26.3 3 14558082 (1)
    melanoma 26.1 7 12370360 (1), 15557163 (1), 11564763 (1), 11929132 (1)
    tumors 0 3 15120646 (1), 19589459 (1)

    Genetic Association Database (GAD): IL26
    Human Genome Epidemiology (HuGE) Navigator: IL26 (10 documents)

    Export disorders for IL26 gene to outside databases

    Publications
    for IL26 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL26 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with IL26)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PubMed id 10729163)1, 2, 3 Knappe A.... Fickenscher H. (2000)
    2. IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PubMed id 14764663)1, 2, 9 Sheikh F.... Kotenko S.V. (2004)
    3. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PubMed id 15178681)1, 2, 9 Hor S.... Fickenscher H. (2004)
    4. Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PubMed id 14558082)1, 4, 9 Vandenbroeck K....Rooney M. (2003)
    5. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PubMed id 18483078)1, 2, 9 Dambacher J.... Brand S. (2009)
    6. Comparative genetic analysis of inflammatory bowel di sease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)1, 4 Wang K....Hakonarson H. (2010)
    7. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Weersma R.K. (2010)
    10. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)1, 4 Silverberg M.S....Duerr R.H. (2009)

    External Searches for IL26 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL26 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55801 HGNC: 17119 AceView: IL26 Ensembl:ENSG00000111536 euGenes: HUgn55801
    ECgene: IL26 Kegg: 55801 H-InvDB: IL26

    Other Databases showing IL26 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL26 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL26 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_26
    SeattleSNPshttp://pga.gs.washington.edu/data/il26/

    Intellectual Property
    for IL26 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL26 gene:
    Search GeneIP for patents involving IL26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IL26 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of IL26
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IL26 (IL-26/AK155)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IL26 (IL-26/AK155)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IL26   OriGene RNAi products in human, mouse, rat for IL26  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IL26  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IL26  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL26   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL26   OriGene Custom Protein Services for IL26  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL26
     QIAGEN SeqTarget long-range PCR primers for resequencing IL26
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL26
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL26
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL26
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL26
     GenScript Custom Purified and Recombinant Proteins Services for IL26 GenScript cDNA clones with any tag delivered in your preferred vector for IL26
     GenScript Custom Assay Services for IL26 GenScript Custom Superior Antibodies Services for IL26
     GenScript Custom overexpressing Cell Line Services for IL26 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IL26 promoter
     Search Chromatin IP Primers for IL26
     RT2 qPCR Primer Assay in human, mouse / rat IL26
     GNC Network for IL26
     SABiosciences PCR Arrays including human, mouse / rat IL26
     Search Tocris compounds for IL26
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IL26 antibodies
     IL26 proteins
     IL26 lysates
     Antibodies for IL26
     See all of Abcam's Antibodies, Kits and Proteins for IL26
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for IL26
     Antibodies for IL26
     ELISAs for IL26
     CLIAs for IL26
     Search LifeMap BioReagents cell lines for IL26
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL26
     SwitchGear 3'UTR luciferase reporter plasmids for IL26
     SwitchGear Promoter luciferase reporter plasmids for IL26
     ThermoFisher Antibodies for IL26
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL26
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IL26
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL26
    Customized:
     lentivirus for stable overexpression of IL26
     lentivirus expression plasmids for stable overexpression of IL26
     adenovirus for overexpression of IL26
     LSBio Antibodies in human, mouse, rat for IL26
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      IL26 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4