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IL26 Gene(Protein Coding)

Interleukin 26

GCID:
GC12M068201
GIFtS:
42
Genes Participants
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Aliases for IL26 Gene

Aliases for IL26 Gene

  • Interleukin 26 2 3 5
  • AK155 3 4
  • IL-26 3 4
  • Interleukin-26 3
  • Protein AK155 4

External Ids for IL26 Gene

Previous GeneCards Identifiers for IL26 Gene

  • GC12M068110
  • GC12M068399
  • GC12M068311
  • GC12M066881
  • GC12M068595
  • GC12M065646

Summaries for IL26 Gene

Entrez Gene Summary for IL26 Gene

  • This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL26 Gene

IL26 (Interleukin 26) is a Protein Coding gene. Diseases associated with IL26 include Inflammatory Bowel Disease. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL26 Gene

  • May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

Gene Wiki entry for IL26 Gene

Additional gene information for IL26 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL26 Gene

Genomics for IL26 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IL26 Gene

Promoters and enhancers for IL26 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I068225 Promoter 0.6 EPDnew 550.8 -0.1 -71 0.1 PKNOX1 IL26 LOC105369818 IL22 IFNG-AS1
GH12I068245 Enhancer 0.9 Ensembl ENCODE 12 -20.1 -20050 1.1 MEIS2 PKNOX1 NFRKB ZIC2 ZNF335 ZFP69B PRDM6 ZNF692 PRDM10 RCOR1 MDM1 IL26 LINC02384 IL22 LOC105369818
GH12I068319 Enhancer 0.8 ENCODE dbSUPER 11.9 -94.5 -94489 0.9 L3MBTL2 NR4A1 MAFG ZNF316 SMARCA4 IKZF1 NFE2 ZNF600 MAFK EMSY GC12M068294 IL26 RPL7P42 NUP107 LOC100507250 RPL10P12 SNORA70G MDM1 IL22
GH12I068290 Enhancer 0.8 ENCODE 11.1 -64.5 -64545 0.2 PKNOX1 BMI1 FEZF1 BATF IRF4 ATF7 ETV6 IKZF2 RUNX3 KLF13 IL26 MDM1 LINC02384 GC12M068294 IL22 LOC105369818
GH12I068174 Enhancer 0.8 Ensembl ENCODE 10.3 +49.4 49372 2.9 ZNF146 ZNF680 JUNB DPF2 ATF2 RELA POLR2A IKZF1 ZNF580 ATF7 LINC02421 IL26 MDM1 LINC01479 IFNG LOC105369818 IFNG-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL26 gene promoter:

Genomic Locations for IL26 Gene

Genomic Locations for IL26 Gene
chr12:68,163,987-68,225,821
(GRCh38/hg38)
Size:
61,835 bases
Orientation:
Minus strand
chr12:68,595,129-68,619,601
(GRCh37/hg19)

Genomic View for IL26 Gene

Genes around IL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL26 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL26 Gene

Proteins for IL26 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH9-IL26_HUMAN
    Recommended name:
    Interleukin-26
    Protein Accession:
    Q9NPH9

    Protein attributes for IL26 Gene

    Size:
    171 amino acids
    Molecular mass:
    19843 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for IL26 Gene

Protein Expression for IL26 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL26 Gene

No Post-translational modifications

Other Protein References for IL26 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL26
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL26

No data available for DME Specific Peptides for IL26 Gene

Domains & Families for IL26 Gene

Gene Families for IL26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPH9

UniProtKB/Swiss-Prot:

IL26_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL26: view

Function for IL26 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IL26 Gene

UniProtKB/Swiss-Prot Function:
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
UniProtKB/Swiss-Prot Induction:
By Herpesvirus saimiri infection.

Phenotypes From GWAS Catalog for IL26 Gene

Gene Ontology (GO) - Molecular Function for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 18483078
genes like me logo Genes that share ontologies with IL26: view
genes like me logo Genes that share phenotypes with IL26: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL26 Gene

Localization for IL26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL26 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL26 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 18483078
GO:0005829 cytosol IDA 18483078
genes like me logo Genes that share ontologies with IL26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL26 Gene

Pathways & Interactions for IL26 Gene

genes like me logo Genes that share pathways with IL26: view

Pathways by source for IL26 Gene

1 KEGG pathway for IL26 Gene
1 R&D Systems pathway for IL26 Gene

Interacting Proteins for IL26 Gene

Selected Interacting proteins: Q9NPH9-IL26_HUMAN for IL26 Gene via IID

SIGNOR curated interactions for IL26 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 10729163
GO:0010469 regulation of receptor activity IEA --
GO:0032874 positive regulation of stress-activated MAPK cascade IDA 18483078
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 18483078
GO:0046427 positive regulation of JAK-STAT cascade IDA 18483078
genes like me logo Genes that share ontologies with IL26: view

Drugs & Compounds for IL26 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IL26 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL26 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL26 Gene

Interleukin 26:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL26 Gene

No ASD Table

Relevant External Links for IL26 Gene

GeneLoc Exon Structure for
IL26
ECgene alternative splicing isoforms for
IL26

Expression for IL26 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL26 Gene

mRNA expression in normal human tissues for IL26 Gene
mRNA expression by GTEx for IL26 GenemRNA expression by BioGPS for IL26 Gene

mRNA differential expression in normal tissues according to GTEx for IL26 Gene

This gene is overexpressed in Colon - Sigmoid (x6.0), Esophagus - Mucosa (x4.5), and Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for IL26 Gene

This gene is overexpressed in Heart (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL26 Gene



Protein tissue co-expression partners for IL26 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL26 Gene:

IL26

SOURCE GeneReport for Unigene cluster for IL26 Gene:

Hs.272350

mRNA Expression by UniProt/SwissProt for IL26 Gene:

Q9NPH9-IL26_HUMAN
Tissue specificity: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohns disease (at protein level).
genes like me logo Genes that share expression patterns with IL26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL26 Gene

Orthologs for IL26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IL26 33 34
  • 99.81 (n)
cow
(Bos Taurus)
 Mammalia IL26 33
  • 89.35 (n)
dog
(Canis familiaris)
 Mammalia IL26 33 34
  • 86.59 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia IL26 34
  • 50 (a)
 OneToOne
Species where no ortholog for IL26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL26 Gene

ENSEMBL:
Gene Tree for IL26 (if available)
TreeFam:
Gene Tree for IL26 (if available)

Paralogs for IL26 Gene

No data available for Paralogs for IL26 Gene

Variants for IL26 Gene

Sequence variations from dbSNP and Humsavar for IL26 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000007312 -- 68,225,249(-) A/G coding_sequence_variant, missense_variant
rs1000134161 -- 68,226,783(-) T/C upstream_transcript_variant
rs1000371251 -- 68,219,284(-) T/C intron_variant
rs1000437279 -- 68,201,447(-) T/G 3_prime_UTR_variant
rs1000447960 -- 68,220,390(-) A/T intron_variant

Variation tolerance for IL26 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL26 Gene

Disorders for IL26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL26 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease
  • inflammatory bowel diseases
- elite association - COSMIC cancer census association via MalaCards
Search IL26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL26 Gene

Publications for IL26 Gene

  1. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PMID: 18483078) Dambacher J … Brand S (Gut 2009) 3 4 22 58
  2. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PMID: 15178681) Hör S … Fickenscher H (The Journal of biological chemistry 2004) 3 4 22 58
  3. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PMID: 14764663) Sheikh F … Kotenko SV (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22 58
  4. Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PMID: 14558082) Vandenbroeck K … Rooney M (Arthritis and rheumatism 2003) 3 22 44 58
  5. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PMID: 10729163) Knappe A … Fickenscher H (Journal of virology 2000) 2 3 4 58

Products for IL26 Gene

Sources for IL26 Gene

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