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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL25 Gene

protein-coding   GIFtS: 55
GCID: GC14P023843

interleukin 25

(Previous name: interleukin 17E )
(Previous symbol: IL17E)
 Explore 11 diseases affiliated with
IL25 via our new
 Human Malady Compendium 
Biological research products
for IL25
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 251 2     IL-251 3
IL17E1 2 3 5     Interleukin-17E3
Interleukin 17E1 2     Interleukin-251
IL-17E1 3     Interleukin-17E3

External Ids:    HGNC: 137651   Entrez Gene: 648062   Ensembl: ENSG000001660907   OMIM: 6056585   UniProtKB: Q9H2933   

Export aliases for IL25 gene to outside databases

Previous GC identifers: GC14P022912 GC14P003958


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL25:
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can
induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are
ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a
pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293
Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8.
Proinflammatory cytokine favoring Th2-type immune responses

Gene Wiki entry for IL25 (Interleukin 25)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL25 gene promoter:
         GR   p53   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL25 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

IL25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL25 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023843:  view genomic region     (about GC identifiers)

Start:
23,842,018 bp from pter      End:
23,845,612 bp from pter
Size:
3,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293 (See protein sequence)
Recommended Name: Interleukin-25 precursor  
Size: 177 amino acids; 20330 Da
Subcellular location: Secreted
Secondary accessions: Q2M3F0 Q8IZV3 Q8WXB0
Alternative splicing: 2 isoforms:  Q9H293-1   Q9H293-2   

Explore the universe of human proteins at neXtProt for IL25: NX_Q9H293

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H293

  • IL25 Protein expression data from MOPED and PaxDb:    About this image 
    IL25 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_073626.1  NP_758525.1  

    ENSEMBL proteins: 
     ENSP00000380417   ENSP00000328111  

    Human Recombinant Protein Products for IL25: 
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    Novus Biologicals IL25 Lysates
    Sino Biological Recombinant Protein for IL25
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    Uscn Proteins for IL25

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0016020membrane NAS--

    IL25 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for IL25


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL25 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR010345 Interleukin-17

    Graphical View of Domain Structure for InterPro Entry Q9H293

    ProtoNet protein and cluster: Q9H293

    1 Blocks protein family: IPB010345 Interleukin-17

    UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293
    Similarity: Belongs to the IL-17 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL25_HUMAN, Q9H293
    Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8.
    Proinflammatory cytokine favoring Th2-type immune responses

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0030380interleukin-17E receptor binding TAS11058597
         
    IL25 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il25):
     digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  no phenotypic analysis  respiratory system 

    IL25 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for IL25: Il25tm1.1Cdon Il25tm1Anjm Il25tm1Lex
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL25 

    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL25


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for IL25):
        Cytokine-cytokine receptor interaction


    IL25 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL25

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for IL25 (Q9H2933 ENSP000003281114) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17RBQ9NRM63, ENSP000002881674I2D: score=3 STRING: ENSP00000288167
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    IL17RAQ96F463I2D: score=1 
    UBQLN4ENSP000003572924STRING: ENSP00000357292
    MGMTENSP000003021114STRING: ENSP00000302111
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002437inflammatory response to antigenic stimulus IEA--
    GO:0006954inflammatory response ----
    GO:0008150biological_process ND--
    GO:0009620response to fungus IEA--
    GO:0009624response to nematode IEA--

    IL25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL25
    Search CenterWatch for drugs/clinical trials and news about IL25 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL25 gene (2 alternative transcripts): 
    NM_022789.3  NM_172314.1  

    Unigene Cluster for IL25:

    Interleukin 25
    Hs.302036
    Unigene Representative Sequence: AF305200
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397242 ENST00000329715(uc001wjq.3 uc001wjr.3)

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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate IL25 (see all 14):
    hsa-miR-519d hsa-miR-20a hsa-miR-550a hsa-miR-106a hsa-miR-1261 hsa-miR-106b hsa-miR-519e hsa-miR-370
    SwitchGear 3'UTR luciferase reporter plasmidIL25 3' UTR sequence
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    Additional cDNA sequence: 

    AF305200.1 AF458059.1 AF461739.1 AY359127.1 BC069565.1 BC104929.1 BC104931.1 

    2 DOTS entries:

    DT.100012346  DT.91670861 

    7 AceView cDNA sequences:

    NM_022789 AF461739 NM_172314 AF305200 AY359127 BC069565 AF458059 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL25    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for IL25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGGCCAGG
    IL25 Expression
    About this image
    See IL25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL25

    SOURCE GeneReport for Unigene cluster: Hs.302036

    UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293
    Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal
    cord, adrenal gland, and trachea

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL25 (see all 6): 
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              Th1/Th2 Response in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL25 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia IL17C6
    --
    20(a)
    1 → many
    GL343670.1(90644-93974)
    zebrafish
    (Danio rerio)
    Actinopterygii il17c6
    interleukin 17c
    19(a)
    1 → many
    18(16735153-16736764)


    ENSEMBL Gene Tree for IL25 (if available)
    TreeFam Gene Tree for IL25 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/115 NCBI SNPs in IL25 are shown (see all 115    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101370821,2
    C,F,A,H--23840033(+) GAGAGC/TGAGAC 1 -- us2k127Minor allele frequency- T:0.21NS EA NA WA CSA 2760
    rs1173345851,2
    --23840034(+) AGAGCG/AAGACC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs736045441,2
    C--23840161(+) AGGAAA/GGGGAG 2 -- us2k12Minor allele frequency- G:0.04WA 120
    rs80175501,2
    C,F,H--23840319(+) GCCAAC/GTAGGG 2 -- us2k132Minor allele frequency- G:0.21NA EU NS EA WA CSA 3277
    rs1405568911,2
    --23840328(+) GGGTAC/GGCACG 2 -- us2k10--------
    rs1457458721,2
    --23840333(+) GGCACA/GGTGTG 2 -- us2k10--------
    rs101494491,2
    C,F,H--23840511(+) GGATAA/GAATGA 2 -- us2k1 tfbs323Minor allele frequency- G:0.13NA EU NS EA WA CSA 2408
    rs1807968211,2
    --23840572(+) AGGAGC/TTGAGG 2 -- us2k10--------
    rs1860961811,2
    --23840751(+) CAAGAA/CTCATC 2 -- us2k10--------
    rs114654991,2
    C--23840778(+) TCCCAA/GTTTTC 2 -- us2k13Minor allele frequency- G:0.01NA EU 94

    HapMap Linkage Disequilibrium report for IL25 (23842018 - 23845612 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL25: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL25 for disorders           About GeneDecksing

    OMIM gene information: 605658    OMIM disorders: --

    11 diseases for IL25:    About MalaCards
    churg-strauss syndrome    inflammatory bowel disease    atopic dermatitis    allergic asthma
    jaundice    dermatitis    eosinophilia    hepatitis b
    asthma    hepatitis    prostatitis

    2 Novoseek disease relationships for IL25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 43.1 8 16792588 (3), 17635955 (2), 19505427 (1)
    autoimmune diseases 28.7 2 14641539 (1)

    Human Genome Epidemiology (HuGE) Navigator: IL25 (3 documents)

    Export disorders for IL25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL25 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with IL25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PubMed id 11058597)1, 2, 3 Lee J.... Gurney A.L. (2001)
    2. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. (PubMed id 11754819)1, 2, 3 Fort M.M.... Rennick D.M. (2001)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Transgenic overexpression of human IL-17E results in eosinophilia, B- lymphocyte hyperplasia, and altered antibody production. (PubMed id 12239140)1, 2 Kim M.R....Medlock E.S. (2002)
    7. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3. (PubMed id 19129540)1, 9 Caruso R....Monteleone G. (2009)
    8. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (PubMed id 17635955)1, 9 Wang Y.H....Liu Y.J. (2007)
    9. [IL-25 derived from epithelial cells has the potential to promote airway remodeling in asthma]. (PubMed id 22691357)1 Liu F....Dong L. (2012)
    10. The involvement of inflammatory cytokines in the patho genesis of recurrent miscarriage. (PubMed id 22266274)1 Giannubilo S.R....Emanuelli M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64806 HGNC: 13765 AceView: IL17E Ensembl:ENSG00000166090 euGenes: HUgn64806
    ECgene: IL25 Kegg: 64806 H-InvDB: IL25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL25 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_17

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL25 gene:
    Search GeneIP for patents involving IL25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

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