IL25 Gene
protein-coding GIFtS: 55
GCID: GC14P023843
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interleukin 25(Previous name: interleukin 17E ) (Previous symbol: IL17E)
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Aliases for IL25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Interleukin 251 2 | | IL-251 3 | | IL17E1 2 3 5 | | Interleukin-17E3 | | Interleukin 17E1 2 | | Interleukin-251 | | IL-17E1 3 | | Interleukin-17E3 |
Export aliases for IL25 gene to outside databasesPrevious GC identifers: GC14P022912 GC14P003958 |
Summaries for IL25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for IL25: The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine caninduce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B areligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be apro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcriptvariants. (provided by RefSeq, Mar 2010) UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8.Proinflammatory cytokine favoring Th2-type immune responses Gene Wiki entry for IL25 (Interleukin 25)
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Genomic Views for IL25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IL25 gene promoter: GR p53 GR-beta GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for IL25
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL25 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2IL25 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P023843: view genomic region
(about GC identifiers)
Start:
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23,842,018 bp from pter |
End:
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23,845,612 bp from pter |
Size:
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3,595 bases |
Orientation:
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plus strand |
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Proteins for IL25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293 (See
protein sequence)Recommended Name: Interleukin-25 precursor Size: 177 amino acids; 20330 Da
Subcellular location: Secreted
Secondary accessions: Q2M3F0 Q8IZV3 Q8WXB0Alternative splicing: 2 isoforms: Q9H293-1 Q9H293-2 Explore the universe of human proteins at neXtProt for IL25: NX_Q9H293
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H293 IL25 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_073626.1 NP_758525.1 ENSEMBL proteins: ENSP00000380417 ENSP00000328111 Human Recombinant Protein Products for IL25:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IL25 for ontologies About GeneDecksing
IL25 Antibody Products: Assay Products for IL25: |
Protein
Domains / Families for IL25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL25 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H293ProtoNet protein and cluster: Q9H293 1 Blocks protein family: IPB010345 Interleukin-17
UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293Similarity: Belongs to the IL-17 family |
Function for IL25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: IL25_HUMAN, Q9H293Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8.Proinflammatory cytokine favoring Th2-type immune responses Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
IL25 for ontologies About GeneDecksing
Phenotypes: 8 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Il25):
IL25 for phenotypes About GeneDecksing
Animal Models: Mouse knock-outs for IL25: Il25tm1.1Cdon Il25tm1Anjm Il25tm1Lex
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL25 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL25 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): IL25 (NM_022789) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL25  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL25 |
|
Pathways & Interactions for IL25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | PEDF Induced Signaling | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Kegg Pathway (Kegg details for IL25):
IL25 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL25
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 5/6 Interacting proteins for IL25 (Q9H2933 ENSP000003281114) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
IL25 for ontologies About GeneDecksing
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Drugs & Compounds for IL25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for IL25 Search CenterWatch for drugs/clinical trials and news about IL25 
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Transcripts for IL25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for IL25 gene (2 alternative transcripts): NM_022789.3 NM_172314.1 Unigene Cluster for IL25: Interleukin 25 Hs.302036 Unigene Representative Sequence: AF3052002 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397242 ENST00000329715(uc001wjq.3 uc001wjr.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL25 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL25 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): IL25 (NM_022789) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL25  |
Additional cDNA sequence: AF305200.1 AF458059.1 AF461739.1 AY359127.1 BC069565.1 BC104929.1 BC104931.1 2 DOTS entries: DT.100012346 DT.91670861 7 AceView cDNA sequences: NM_022789 AF461739 NM_172314 AF305200 AY359127 BC069565 AF458059 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for IL25 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for IL25
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Expression for IL25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL25 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAGGGCCAGG
 About this image See IL25 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IL25
SOURCE GeneReport for Unigene cluster: Hs.302036
UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinalcord, adrenal gland, and trachea SABiosciences Expression via Pathway-Focused PCR Arrays including IL25 (see all 6):
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL25 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL25 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL25 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL25 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL25 |
Orthologs for IL25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL25 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
IL17C6 |
-- |
20(a) |
1 → many |
GL343670.1(90644-93974) |
zebrafish (Danio rerio) |
Actinopterygii |
il17c6 |
interleukin 17c |
19(a) |
1 → many |
18(16735153-16736764) |
ENSEMBL Gene Tree for IL25 (if available) TreeFam Gene Tree for IL25 (if available)  |
Paralogs for IL25 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for IL25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 14 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for IL25 (23842018 - 23845612 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for IL25: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL25 |
|
Disorders
/ Diseases for IL25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL25 for disorders About GeneDecksing
OMIM gene information: 605658
OMIM disorders: --
11 diseases for IL25: About MalaCardschurg-strauss syndrome inflammatory bowel disease atopic dermatitis allergic asthma jaundice dermatitis eosinophilia hepatitis b asthma hepatitis prostatitis
2 Novoseek disease relationships for IL25 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
43.1 |
8 |
16792588 (3), 17635955 (2), 19505427 (1) |
| autoimmune diseases |
28.7 |
2 |
14641539 (1) |
Human Genome Epidemiology (HuGE) Navigator: IL25 (3 documents) Export disorders for IL25 gene to outside databases
|
Publications for IL25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL25 gene, integrated from 9 sources (see all 46): (articles sorted by number of sources associating them with IL25) | |  | Utopia: connect your pdf to the dynamic world of online information |
- IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PubMed id 11058597)1, 2, 3 Lee J.... Gurney A.L. (2001)
- IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. (PubMed id 11754819)1, 2, 3 Fort M.M.... Rennick D.M. (2001)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Transgenic overexpression of human IL-17E results in eosinophilia, B- lymphocyte hyperplasia, and altered antibody production. (PubMed id 12239140)1, 2 Kim M.R....Medlock E.S. (2002)
- Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3. (PubMed id 19129540)1, 9 Caruso R....Monteleone G. (2009)
- IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (PubMed id 17635955)1, 9 Wang Y.H....Liu Y.J. (2007)
- [IL-25 derived from epithelial cells has the potential to promote airway remodeling in asthma]. (PubMed id 22691357)1 Liu F....Dong L. (2012)
- The involvement of inflammatory cytokines in the patho genesis of recurrent miscarriage. (PubMed id 22266274)1 Giannubilo S.R....Emanuelli M. (2012)
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External Searches for IL25 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing IL25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for IL25 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Interleukin_17 |
|
| | |
About This Section
| Patent Information for IL25 gene: Search GeneIP for patents involving IL25
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for IL25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for IL25 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL25 | | OriGene Protein Over-expression Lysate for IL25 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for IL25 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL25 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for IL25 | | OriGene Custom Protein Services for IL25 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL25 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL25 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL25 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL25 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL25 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL25 |
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 | | IL25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL25 |
|  |  |  |  | | | ThermoFisher Antibodies for IL25 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL25 |
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