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Aliases for IL25 Gene

Aliases for IL25 Gene

  • Interleukin 25 2 3
  • IL17E 3 4 6
  • Interleukin-17E 3 4
  • Interleukin 17E 2
  • Interleukin-25 3
  • IL-17E 4
  • IL-25 4

External Ids for IL25 Gene

Previous HGNC Symbols for IL25 Gene

  • IL17E

Previous GeneCards Identifiers for IL25 Gene

  • GC14P022912
  • GC14P023843
  • GC14P003958
  • GC14P023857

Summaries for IL25 Gene

Entrez Gene Summary for IL25 Gene

  • The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for IL25 Gene

IL25 (Interleukin 25) is a Protein Coding gene. Diseases associated with IL25 include allergic asthma. Among its related pathways are IL-17 Family Signaling Pathways and IL-17 Family Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-17E receptor binding.

UniProtKB/Swiss-Prot for IL25 Gene

  • Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses

Gene Wiki entry for IL25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL25 Gene

Genomics for IL25 Gene

Regulatory Elements for IL25 Gene

Genomic Location for IL25 Gene

Start:
23,372,809 bp from pter
End:
23,376,403 bp from pter
Size:
3,595 bases
Orientation:
Plus strand

Genomic View for IL25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL25 Gene

Proteins for IL25 Gene

  • Protein details for IL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H293-IL25_HUMAN
    Recommended name:
    Interleukin-25
    Protein Accession:
    Q9H293
    Secondary Accessions:
    • Q2M3F0
    • Q8IZV3
    • Q8WXB0

    Protein attributes for IL25 Gene

    Size:
    177 amino acids
    Molecular mass:
    20330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL25 Gene

Proteomics data for IL25 Gene at MOPED

Post-translational modifications for IL25 Gene

  • Glycosylation at Asn136
  • Modification sites at PhosphoSitePlus

Other Protein References for IL25 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for IL25 Gene

Domains for IL25 Gene

Gene Families for IL25 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL25 Gene

Suggested Antigen Peptide Sequences for IL25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H293

UniProtKB/Swiss-Prot:

IL25_HUMAN :
  • Q9H293
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL25: view

Function for IL25 Gene

Molecular function for IL25 Gene

UniProtKB/Swiss-Prot Function:
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses

Gene Ontology (GO) - Molecular Function for IL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0030380 interleukin-17E receptor binding TAS 11058597
genes like me logo Genes that share ontologies with IL25: view
genes like me logo Genes that share phenotypes with IL25: view

Animal Models for IL25 Gene

MGI Knock Outs for IL25:

Animal Model Products

miRNA for IL25 Gene

miRTarBase miRNAs that target IL25

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL25 Gene

Localization for IL25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL25 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL25 Gene COMPARTMENTS Subcellular localization image for IL25 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for IL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL25: view

Pathways for IL25 Gene

genes like me logo Genes that share pathways with IL25: view

Pathways by source for IL25 Gene

1 BioSystems pathway for IL25 Gene
1 KEGG pathway for IL25 Gene
1 R&D Systems pathway for IL25 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for IL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0006954 inflammatory response --
GO:0008150 biological_process ND --
GO:0009620 response to fungus IEA --
GO:0009624 response to nematode IEA --
genes like me logo Genes that share ontologies with IL25: view

Transcripts for IL25 Gene

mRNA/cDNA for IL25 Gene

(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL25 Gene

Interleukin 25:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL25

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for IL25 Gene

GeneLoc Exon Structure for
IL25
ECgene alternative splicing isoforms for
IL25

Expression for IL25 Gene

mRNA expression in normal human tissues for IL25 Gene

mRNA differential expression in normal tissues according to GTEx for IL25 Gene

This gene is overexpressed in Testis (7.0) and Heart - Atrial Appendage (5.9).

SOURCE GeneReport for Unigene cluster for IL25 Gene Hs.302036

mRNA Expression by UniProt/SwissProt for IL25 Gene

Q9H293-IL25_HUMAN
Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea
genes like me logo Genes that share expressions with IL25: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for IL25 Gene

Orthologs for IL25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL25 35
  • 84.27 (n)
  • 78.26 (a)
IL25 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL25 35
  • 83.02 (n)
  • 76.73 (a)
IL25 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il25 35
  • 84.06 (n)
  • 78.88 (a)
Il25 16
Il25 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL25 35
  • 98.34 (n)
  • 96.89 (a)
IL25 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il25 35
  • 81.57 (n)
  • 78.88 (a)
oppossum
(Monodelphis domestica)
Mammalia IL25 36
  • 52 (a)
OneToOne
Species with no ortholog for IL25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL25 Gene

ENSEMBL:
Gene Tree for IL25 (if available)
TreeFam:
Gene Tree for IL25 (if available)

Paralogs for IL25 Gene

No data available for Paralogs for IL25 Gene

Variants for IL25 Gene

Sequence variations from dbSNP and Humsavar for IL25 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7145531 -- 23,372,808(+) TTTAA(C/T)CTCAA upstream-variant-2KB
rs7145551 -- 23,372,831(+) AAAGA(C/T)AGTGG upstream-variant-2KB, utr-variant-5-prime
rs8003073 -- 23,372,184(+) GGGGA(C/T)ACTCA upstream-variant-2KB
rs8014568 -- 23,374,154(+) CAGAT(C/T)TAACT intron-variant
rs8017550 -- 23,371,110(+) GCCAA(C/G)TAGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL25 Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Relevant External Links for IL25 Gene

HapMap Linkage Disequilibrium report
IL25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL25 Gene

Disorders for IL25 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IL25 Gene in MalaCards »

(1) Diseases for IL25 Gene including...

(2) Novoseek inferred disease relationships for IL25 Gene

Disease -log(P) Hits PubMed IDs
inflammation 43.1 6
autoimmune diseases 28.7 1

Relevant External Links for IL25

Genetic Association Database (GAD)
IL25
Human Genome Epidemiology (HuGE) Navigator
IL25
genes like me logo Genes that share disorders with IL25: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for IL25 Gene

Publications for IL25 Gene

  1. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PMID: 11058597) Lee J. … Gurney A.L. (J. Biol. Chem. 2001) 2 3 4
  2. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. (PMID: 11754819) Fort M.M. … Rennick D.M. (Immunity 2001) 2 3 4
  3. Transgenic overexpression of human IL-17E results in eosinophilia, B- lymphocyte hyperplasia, and altered antibody production. (PMID: 12239140) Kim M.R. … Medlock E.S. (Blood 2002) 3 4
  4. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (PMID: 17635955) Wang Y.H. … Liu Y.J. (J. Exp. Med. 2007) 3 23
  5. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield J.P. … Hakonarson H. (PLoS Genet. 2011) 3 48

Products for IL25 Gene

Sources for IL25 Gene

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