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Aliases for IL25 Gene

Aliases for IL25 Gene

  • Interleukin 25 2 3 5
  • Interleukin-17E 3 4
  • IL17E 3 4
  • Interleukin 17E 2
  • IL-17E 4
  • IL-25 4

External Ids for IL25 Gene

Previous HGNC Symbols for IL25 Gene

  • IL17E

Previous GeneCards Identifiers for IL25 Gene

  • GC14P022912
  • GC14P023843
  • GC14P003958
  • GC14P023857
  • GC14P023467
  • GC14P023500

Summaries for IL25 Gene

Entrez Gene Summary for IL25 Gene

  • The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for IL25 Gene

IL25 (Interleukin 25) is a Protein Coding gene. Among its related pathways are Immune System and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and interleukin-17E receptor binding.

UniProtKB/Swiss-Prot for IL25 Gene

  • Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

Gene Wiki entry for IL25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL25 Gene

Genomics for IL25 Gene

Regulatory Elements for IL25 Gene

Enhancers for IL25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL25 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL25 Gene

23,372,809 bp from pter
23,376,403 bp from pter
3,595 bases
Plus strand

Genomic View for IL25 Gene

Genes around IL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL25 Gene

Proteins for IL25 Gene

  • Protein details for IL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q2M3F0
    • Q8IZV3
    • Q8WXB0

    Protein attributes for IL25 Gene

    177 amino acids
    Molecular mass:
    20330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL25 Gene


neXtProt entry for IL25 Gene

Proteomics data for IL25 Gene at MOPED

Post-translational modifications for IL25 Gene

  • Glycosylation at Asn 136
  • Modification sites at PhosphoSitePlus

Other Protein References for IL25 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL25 Gene

Domains & Families for IL25 Gene

Gene Families for IL25 Gene

Protein Domains for IL25 Gene

Suggested Antigen Peptide Sequences for IL25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-17 family.
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL25: view

Function for IL25 Gene

Molecular function for IL25 Gene

UniProtKB/Swiss-Prot Function:
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
genes like me logo Genes that share phenotypes with IL25: view

Animal Models for IL25 Gene

MGI Knock Outs for IL25:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL25

miRNA for IL25 Gene

miRTarBase miRNAs that target IL25

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL25 Gene

Localization for IL25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL25 Gene


Subcellular locations from

Jensen Localization Image for IL25 Gene COMPARTMENTS Subcellular localization image for IL25 gene
Compartment Confidence
extracellular 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for IL25 Gene

Pathways & Interactions for IL25 Gene

genes like me logo Genes that share pathways with IL25: view

Pathways by source for IL25 Gene

Gene Ontology (GO) - Biological Process for IL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008150 biological_process ND --
GO:0009620 response to fungus IEA --
GO:0032616 interleukin-13 production IEA --
GO:0032634 interleukin-5 production IEA --
genes like me logo Genes that share ontologies with IL25: view

No data available for SIGNOR curated interactions for IL25 Gene

Drugs & Compounds for IL25 Gene

(1) Drugs for IL25 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vidofludimus Pharma inhibitor 0
genes like me logo Genes that share compounds with IL25: view

Transcripts for IL25 Gene

mRNA/cDNA for IL25 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL25 Gene

Interleukin 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for IL25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL25 Gene

mRNA expression in normal human tissues for IL25 Gene

mRNA differential expression in normal tissues according to GTEx for IL25 Gene

This gene is overexpressed in Testis (x7.0) and Heart - Atrial Appendage (x5.9).

SOURCE GeneReport for Unigene cluster for IL25 Gene Hs.302036

mRNA Expression by UniProt/SwissProt for IL25 Gene

Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
genes like me logo Genes that share expression patterns with IL25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL25 Gene

Orthologs for IL25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL25 35
  • 84.27 (n)
  • 78.26 (a)
IL25 36
  • 73 (a)
(Canis familiaris)
Mammalia IL25 35
  • 83.02 (n)
  • 76.73 (a)
IL25 36
  • 72 (a)
(Mus musculus)
Mammalia Il25 35
  • 84.06 (n)
  • 78.88 (a)
Il25 16
Il25 36
  • 75 (a)
(Pan troglodytes)
Mammalia IL25 35
  • 98.34 (n)
  • 96.89 (a)
IL25 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Il25 35
  • 81.57 (n)
  • 78.88 (a)
(Monodelphis domestica)
Mammalia IL25 36
  • 52 (a)
Species with no ortholog for IL25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL25 Gene

Gene Tree for IL25 (if available)
Gene Tree for IL25 (if available)

Paralogs for IL25 Gene

No data available for Paralogs for IL25 Gene

Variants for IL25 Gene

Sequence variations from dbSNP and Humsavar for IL25 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8003073 -- 23,372,184(+) GGGGA(C/T)ACTCA upstream-variant-2KB
rs8017550 -- 23,371,110(+) GCCAA(C/G)TAGGG upstream-variant-2KB
rs7145531 -- 23,372,808(+) TTTAA(C/T)CTCAA upstream-variant-2KB
rs7145551 -- 23,372,831(+) AAAGA(C/T)AGTGG upstream-variant-2KB, utr-variant-5-prime
rs10143597 -- 23,373,530(+) ACAAG(G/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL25 Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Variation tolerance for IL25 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL25 Gene

Disorders for IL25 Gene

Relevant External Links for IL25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IL25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL25 Gene

Publications for IL25 Gene

  1. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PMID: 11058597) Lee J. … Gurney A.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3. (PMID: 19129540) Caruso R. … Monteleone G. (Blood 2009) 3 23
  3. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (PMID: 17635955) Wang Y.H. … Liu Y.J. (J. Exp. Med. 2007) 3 23
  4. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. (PMID: 11754819) Fort M.M. … Rennick D.M. (Immunity 2001) 2 3
  5. Increased expression of thymic stromal lymphopoietin and its receptor in Kimura's disease. (PMID: 25676453) Sakitani E. … Yoshihara T. (ORL J. Otorhinolaryngol. Relat. Spec. 2015) 3

Products for IL25 Gene

Sources for IL25 Gene