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IL25 Gene

protein-coding   GIFtS: 56
GCID: GC14P023857

Interleukin 25

(Previous name: interleukin 17E)
(Previous symbol: IL17E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 251 2     interleukin-252
IL17E1 2 3 5     IL-17E3
Interleukin 17E1     IL-253
interleukin-17E2     Interleukin-17E3

External Ids:    HGNC: 137651   Entrez Gene: 648062   Ensembl: ENSG000001660907   OMIM: 6056585   UniProtKB: Q9H2933   

Export aliases for IL25 gene to outside databases

Previous GC identifers: GC14P022912 GC14P023843 GC14P003958


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL25 Gene:
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine
can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and
interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this
cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for IL25 Gene:
IL25 (interleukin 25) is a protein-coding gene. Diseases associated with IL25 include allergic asthma, and churg-strauss syndrome. GO annotations related to this gene include interleukin-17E receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293
Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8.
Proinflammatory cytokine favoring Th2-type immune responses

Gene Wiki entry for IL25 (Interleukin 25) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL25 gene promoter:
         GR   p53   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL25 promoter sequence
   Search Chromatin IP Primers for IL25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

IL25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL25 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023857:  view genomic region     (about GC identifiers)

Start:
23,842,018 bp from pter      End:
23,845,612 bp from pter
Size:
3,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293 (See protein sequence)
Recommended Name: Interleukin-25 precursor  
Size: 177 amino acids; 20330 Da
Secondary accessions: Q2M3F0 Q8IZV3 Q8WXB0
Alternative splicing: 2 isoforms:  Q9H293-1   Q9H293-2   

Explore the universe of human proteins at neXtProt for IL25: NX_Q9H293

Explore proteomics data for IL25 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn136

  • See IL25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_073626.1  NP_758525.1  

    ENSEMBL proteins: 
     ENSP00000380417   ENSP00000328111  

    IL25 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL25 (IL-17E/IL-25)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL25
    OriGene Protein Over-expression Lysate for IL25
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL25
    GenScript Purified and Recombinant Proteins for IL25
    Novus Biologicals IL25 Proteins
    Novus Biologicals IL25 Lysates
    Sino Biological Recombinant Protein for IL25
    Sino Biological Cell Lysate for IL25
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IL25

    IL25 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL25
    R&D Systems Antibodies for IL25 (IL-17E/IL-25)
    OriGene Antibodies for IL25
    OriGene Custom Antibody Services for IL25
    Novus Biologicals IL25 Antibodies
    Abcam antibodies for IL25
    Cloud-Clone Corp. Antibodies for IL25
    ThermoFisher Antibodies for IL25
    LSBio Antibodies in human, mouse, rat for IL25

    IL25 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL25
    R&D Systems Proteome Profiler Antibody Arrays for IL25 (IL-17E/IL-25)
    GenScript Custom Assay Services for IL25
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL25
    Cloud-Clone Corp. CLIAs for IL25


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    1 InterPro protein domain:
     IPR010345 IL-17_fam

    Graphical View of Domain Structure for InterPro Entry Q9H293

    ProtoNet protein and cluster: Q9H293

    1 Blocks protein domain: IPB010345 Interleukin-17

    UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293
    Similarity: Belongs to the IL-17 family


    IL25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL25_HUMAN, Q9H293
    Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8.
    Proinflammatory cytokine favoring Th2-type immune responses

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0030380interleukin-17E receptor binding TAS11058597
         
    IL25 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il25):
     digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  no phenotypic analysis  respiratory system 

    IL25 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL25: Il25tm1.1Cdon Il25tm1Anjm Il25tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL25
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL25
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL25

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL25:
    hsa-mir-335-5p (MIRT016919)

    Block miRNA regulation of human, mouse, rat IL25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL25 (see all 14):
    hsa-miR-519d hsa-miR-20a hsa-miR-550a hsa-miR-106a hsa-miR-1261 hsa-miR-106b hsa-miR-519e hsa-miR-370
    SwitchGear 3'UTR luciferase reporter plasmidIL25 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL25
    Predesigned siRNA for gene silencing in human, mouse, rat IL25

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL25

    Clone
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    OriGene clones in human, mouse for IL25 (see all 11)
    OriGene ORF clones in mouse, rat for IL25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL25 (NM_022789)
    Sino Biological Human cDNA Clone for IL25
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL25

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL25
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL25 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL25_HUMAN, Q9H293: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0016020membrane ----

    IL25 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL25 About    
    See pathways by source

    SuperPathContained pathways About
    1IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    IL17 signaling pathway0.51
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL25
        IL-17 Family Signaling Pathways


    1 BioSystems Pathway for IL25
        IL17 signaling pathway



    1 Kegg Pathway  (Kegg details for IL25):
        Cytokine-cytokine receptor interaction


    IL25 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL25 (see all 6): 
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL25

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for IL25 (Q9H2933 ENSP000003281114) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17RBQ9NRM63, ENSP000002881674I2D: score=3 STRING: ENSP00000288167
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    IL17RAQ96F463I2D: score=1 
    UBQLN4ENSP000003572924STRING: ENSP00000357292
    MGMTENSP000003021114STRING: ENSP00000302111
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002437inflammatory response to antigenic stimulus IEA--
    GO:0006954inflammatory response ----
    GO:0008150biological_process ND--
    GO:0009620response to fungus IEA--
    GO:0009624response to nematode IEA--

    IL25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL25



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL25 gene (2 alternative transcripts): 
    NM_022789.3  NM_172314.1  

    Unigene Cluster for IL25:

    Interleukin 25
    Hs.302036
    Unigene Representative Sequence: AF305200
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397242 ENST00000329715(uc001wjq.3 uc001wjr.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL25 (see all 14):
    hsa-miR-519d hsa-miR-20a hsa-miR-550a hsa-miR-106a hsa-miR-1261 hsa-miR-106b hsa-miR-519e hsa-miR-370
    SwitchGear 3'UTR luciferase reporter plasmidIL25 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL25
    Predesigned siRNA for gene silencing in human, mouse, rat IL25
    Clone
    Products:
         
    OriGene clones in human, mouse for IL25 (see all 11)
    OriGene ORF clones in mouse, rat for IL25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL25 (NM_022789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL25
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL25
    OriGene qSTAR qPCR primer pairs in human, mouse for IL25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL25
      QuantiTect SYBR Green Assays in human, mouse, rat IL25
      QuantiFast Probe-based Assays in human, mouse, rat IL25

    Additional mRNA sequence: 

    AF305200.1 AF458059.1 AF461739.1 AY359127.1 BC069565.1 BC104929.1 BC104931.1 

    2 DOTS entries:

    DT.100012346  DT.91670861 

    7 AceView cDNA sequences:

    NM_022789 AF461739 NM_172314 AF305200 AY359127 BC069565 AF458059 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL25    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for IL25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGCCAGG
    IL25 Expression
    About this image

    IL25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302036

    UniProtKB/Swiss-Prot: IL25_HUMAN, Q9H293
    Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis,
    spinal cord, adrenal gland, and trachea

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL25 (see all 6): 
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL25
    OriGene qSTAR qPCR primer pairs in human, mouse for IL25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL25
    QuantiTect SYBR Green Assays in human, mouse, rat IL25
    QuantiFast Probe-based Assays in human, mouse, rat IL25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL25 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il251 , 5 interleukin 251, 5 84.06(n)1
    78.88(a)1
      14 (28.00 cM)5
    1408061  NM_080729.31  NP_542767.11 
     549326955 


    ENSEMBL Gene Tree for IL25 (if available)
    TreeFam Gene Tree for IL25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL25 (see all 91)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101370821,2
    C,F,A,H--23840033(+) GAGAGC/TGAGAC 1 -- us2k127Minor allele frequency- T:0.21NS EA NA WA CSA 2760
    rs1173345851,2
    C,F--23840034(+) AGAGCG/AAGACC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs736045441,2
    C,F--23840161(+) AGGAAA/GGGGAG 2 -- us2k12Minor allele frequency- G:0.04WA 120
    rs80175501,2
    C,F,H--23840319(+) GCCAAC/GTAGGG 2 -- us2k132Minor allele frequency- G:0.21NA EU NS EA WA CSA 3277
    rs1405568911,2
    C--23840328(+) GGGTAC/GGCACG 2 -- us2k10--------
    rs1457458721,2
    --23840333(+) GGCACA/GGTGTG 2 -- us2k10--------
    rs101494491,2
    C,F,H--23840511(+) GGATAA/GAATGA 2 -- us2k1 tfbs323Minor allele frequency- G:0.13NA EU NS EA WA CSA 2408
    rs1807968211,2
    --23840572(+) AGGAGC/TTGAGG 2 -- us2k10--------
    rs1860961811,2
    --23840751(+) CAAGAA/CTCATC 2 -- us2k10--------
    rs114654991,2
    C,F--23840778(+) TCCCAA/GTTTTC 2 -- us2k13Minor allele frequency- G:0.01NA EU 94

    HapMap Linkage Disequilibrium report for IL25 (23842018 - 23845612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901493CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL25
    DNA2.0 Custom Variant and Variant Library Synthesis for IL25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605658    OMIM disorders: --

    11 diseases for IL25:    
    About MalaCards
    allergic asthma    churg-strauss syndrome    atopic dermatitis    eosinophilia
    dermatitis    asthma    inflammatory bowel disease    type 1 diabetes
    hepatitis b    hepatitis    prostatitis


    IL25 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IL25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 43.1 8 16792588 (3), 17635955 (2), 19505427 (1)
    autoimmune diseases 28.7 2 14641539 (1)

    Genetic Association Database (GAD): IL25
    Human Genome Epidemiology (HuGE) Navigator: IL25 (3 documents)

    Export disorders for IL25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL25 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with IL25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PubMed id 11058597)1, 2, 3 Lee J.... Gurney A.L. (J. Biol. Chem. 2001)
    2. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. (PubMed id 11754819)1, 2, 3 Fort M.M.... Rennick D.M. (Immunity 2001)
    3. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PubMed id 21980299)1, 4 Bradfield J.P....Hakonarson H. (PLoS Genet. 2011)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Transgenic overexpression of human IL-17E results in eosinophilia, B- lymphocyte hyperplasia, and altered antibody production. (PubMed id 12239140)1, 2 Kim M.R....Medlock E.S. (Blood 2002)
    8. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3. (PubMed id 19129540)1, 9 Caruso R....Monteleone G. (Blood 2009)
    9. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (PubMed id 17635955)1, 9 Wang Y.H....Liu Y.J. (J. Exp. Med. 2007)
    10. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. (PubMed id 24344271)1 Hams E....Fallon P.G. (Proc. Natl. Acad. Sci. U.S.A. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64806 HGNC: 13765 AceView: IL17E Ensembl:ENSG00000166090 euGenes: HUgn64806
    ECgene: IL25 Kegg: 64806 H-InvDB: IL25

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL25 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_17

    (Patent information from GeneIP,
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