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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL24 Gene

protein-coding   GIFtS: 62
GCID: GC01P207070

interleukin 24


(Previous symbol: ST16)
 Explore 39 diseases affiliated with
IL24 via our new
 Human Malady Compendium 
Biological research products
for IL24
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 241 2     Mda-71
ST161 2 3 5     MOB52
MDA72 3 5     IL-4-Induced Secreted Protein2
C49A1 2     Interleukin-241
FISP1 2     Melanocyte-Associated Mda-72
IL10B1 2     Suppression Of Tumorigenicity 16 (Melanoma Differentiation)2
IL-241 3     MDA-73
Melanoma Differentiation-Associated Gene 7 Protein2 3     Suppression Of Tumorigenicity 16 Protein3
Mob-51     

External Ids:    HGNC: 113461   Entrez Gene: 110092   Ensembl: ENSG000001628927   OMIM: 6041365   UniProtKB: Q130073   

Export aliases for IL24 gene to outside databases

Previous GC identifers: GC01P205730 GC01P202781 GC01P203714 GC01P204154 GC01P203459 GC01P205137 GC01P177769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL24:
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal
differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer
cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with
the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock
27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal
melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

Gene Wiki entry for IL24 (Interleukin 24)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL24 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL24 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

IL24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL24 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207070:  view genomic region     (about GC identifiers)

Start:
207,070,788 bp from pter      End:
207,077,484 bp from pter
Size:
6,697 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007 (See protein sequence)
Recommended Name: Interleukin-24 precursor  
Size: 206 amino acids; 23825 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q2YHE5 Q53XZ7 Q5YLN8 Q96DB0 Q96KG4
Alternative splicing: 4 isoforms:  Q13007-1   Q13007-2   Q13007-3   Q13007-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL24: NX_Q13007

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13007

  • IL24 Protein expression data from MOPED and PaxDb:    About this image 
    IL24 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001172085.1  NP_001172086.1  NP_001172087.1  NP_006841.1  

    ENSEMBL proteins: 
     ENSP00000375795   ENSP00000294984   ENSP00000356062   ENSP00000356060   ENSP00000418933  

    Human Recombinant Protein Products for IL24: 
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    OriGene Protein Over-expression Lysate: IL24
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    Novus Biologicals IL24 Proteins
    Novus Biologicals IL24 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for IL24
    Uscn Proteins for IL24

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    IL24 for ontologies           About GeneDecksing



    IL24 Antibody Products: 
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    Uscn ELISAs and CLIAs for IL24


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL24 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR009079 4_helix_cytokine-like_core
     IPR020444 Interleukin-24
     IPR012351 4_helix_cytokine_core
     IPR020423 Interleukin-10_CS
     IPR020443 Interleukin-10/19/20/24

    Graphical View of Domain Structure for InterPro Entry Q13007

    ProtoNet protein and cluster: Q13007

    1 Blocks protein family: IPB000098 Interleukin-10

    UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
    Similarity: Belongs to the IL-10 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL24_HUMAN, Q13007
    Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    IL24 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL24:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Il24):
     homeostasis/metabolism 

    IL24 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Il24tm1Dnax for IL24
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL24 

    miRNA
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    miRTarBase miRNAs that target IL24:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL24
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): IL24 (NM_006850)
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL24


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/12 pathways (see all 12)
    PEDF Induced Signaling1.00
    STAT3 Pathway0.47
    MIF Mediated Glucocorticoid Regulation0.73
    Endothelin-1 Signaling Pathway0.44
    MIF Regulation of Innate Immune Cells0.71
    NFAT Signaling and Lymphocyte Interactions0.37
    IL-6 Pathway0.61
    PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    TGF-Beta Pathway1.00
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.29
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling1.00
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Rho Family GTPases
    Rho Family GTPases1.00
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway1.00
    Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for IL24
        Selected targets of C/EBPbeta
    Selected targets of C/EBPalpha

    5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL24 (see all 24)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    2 BioSystems Pathways for IL24 
        Senescence and Autophagy
    IL23-mediated signaling events


    2         Kegg Pathways  (Kegg details for IL24):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IL24 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for IL24 (Q130073 ENSP000002949844) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL20RAQ9UHF43, ENSP000003149764I2D: score=1 STRING: ENSP00000314976
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    IL20RBQ6UXL03I2D: score=1 
    COMMD3ENSP000003660324STRING: ENSP00000366032
    ENSG00000206435ENSP000003729754STRING: ENSP00000372975
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0030336negative regulation of cell migration IEA--
    GO:0033136serine phosphorylation of STAT3 protein IEA--

    IL24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL24 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL24
    5 Novoseek chemical compound relationships for IL24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mezerein 81.9 14 8545104 (3), 10713678 (3), 10942517 (1)
    il 10 63 1 19802007 (1)
    trastuzumab 32.2 2 15300212 (1), 16783343 (1)
    vegf 20.1 3 17235306 (2), 16054437 (1)
    oxygen 0 1 15880678 (1)

    Search CenterWatch for drugs/clinical trials and news about IL24 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL24 gene (5 alternative transcripts): 
    NM_001185156.1  NM_001185157.1  NM_001185158.1  NM_006850.3  NM_181339.1  

    Unigene Cluster for IL24:

    Interleukin 24
    Hs.58831  [show with all ESTs]
    Unigene Representative Sequence: NM_001185156
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391929 ENST00000294984 ENST00000367095(uc001hex.2 uc001hev.2)
    ENST00000367093(uc001heu.2 uc001hes.2 uc001hew.2) ENST00000491169
    ENST00000480741

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL24
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL24:
    hsa-miR-203 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL24 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL24
    Sirion Biotech Custom design and validation of potent shRNA sequences against IL24 
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL24 (see all 6)
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    Additional cDNA sequence: 

    AY237723.1 AY641440.1 AY641441.1 BC009681.1 BT007156.1 U16261.1 

    4 DOTS entries:

    DT.453471  DT.40114875  DT.101976578  DT.121352756 

    24/154 AceView cDNA sequences (see all 154):

    AW242211 AI762709 CK904055 AI399732 AI760350 BP340505 AA769190 AA743771 
    AI479031 NM_005449 CR625287 BG055089 AA804450 AW137293 BQ707299 AW571597 
    BP338035 BQ707120 AA732513 BI966187 AI865238 AI439553 AA832318 BQ706388 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL24 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                                                                              
    SP2:                                -           -     -                           
    SP3:                    -     -     -                                             
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for IL24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAATCACAC
    IL24 Expression
    About this image
    See IL24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL24

    SOURCE GeneReport for Unigene cluster: Hs.58831

    UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
    Tissue specificity: Up-regulated in melanoma cells induced to terminally differentiate

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL24: 
              Th1/Th2 Response in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL24
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL24 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il241 , 5 interleukin 241, 5 76.52(n)1
    66.13(a)1
      1 (56.89 cM)5
    936721  NM_053095.21  NP_444325.21 
     1308820745 
    lizard
    (Anolis carolinensis)
    Reptilia IL246
    --
    32(a)
    1 ↔ 1
    GL343228.1(1949292-1953668)
    zebrafish
    (Danio rerio)
    Actinopterygii il346
    interleukin 34
    30(a)
    1 → many
    11(21929589-21932934)


    ENSEMBL Gene Tree for IL24 (if available)
    TreeFam Gene Tree for IL24 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL24 gene
    IL192  IL202  
    1 SIMAP similar gene for IL24 using alignment to 3 protein entries:     IL24_HUMAN (see all proteins):
    IL20

    IL24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/138 NCBI SNPs in IL24 are shown (see all 138    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741488791,2
    C--177767366(+) GGGAAG/CGGGGG 4 -- us2k11Minor allele frequency- C:0.50WA 2
    rs730890851,2
    C--177767375(+) GGAGTG/CGGGGA 4 -- us2k11Minor allele frequency- C:0.50WA 2
    rs38139581,2
    C,H--177767400(-) GGCACA/GGCCCC 4 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs730890871,2
    C--177767681(+) ACTCCC/TGTTTC 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs30934131,2
    C,F--177767791(+) tctctG/Acctct 4 -- us2k14Minor allele frequency- A:0.03NS CSA WA 202
    rs2911111,2
    C,F,A,H--177767798(-) gtgctA/Gcagag 4 -- us2k118Minor allele frequency- G:0.10NS EA NA CSA WA 2224
    rs730890911,2
    C--177767921(+) CATTAG/AAAAAC 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs2911101,2
    C,F,H--177767970(-) CTGCTA/CAGCTG 4 -- us2k122Minor allele frequency- C:0.05NS EA NA WA 2678
    rs30934141,2
    F--177768783(+) TTTTTTA/-AAAAT 4 -- us2k12Minor allele frequency- -:0.07NS 82
    rs30934151,2
    C,F,H--177768791(+) NNNNTT/CATACA 4 -- us2k1 tfbs39Minor allele frequency- C:0.01NS EA NA 598

    HapMap Linkage Disequilibrium report for IL24 (207070788 - 207077484 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL24: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL24 for disorders           About GeneDecksing

    OMIM gene information: 604136    OMIM disorders: --

    20/39 diseases for IL24 (see all 39):    About MalaCards
    melanoma    major depressive disorder    inflammatory bowel disease    chronic lymphocytic leukemia
    lymphocytic leukemia    malignant glioma    bronchiolitis    spondyloarthropathy
    ovarian carcinoma    carcinoma    rheumatoid arthritis    pancreatitis
    pancreatic carcinoma    keloids    ovarian cancer    influenza
    psoriasis    pancreatic cancer    breast carcinoma    skin disease

    1 disease from the University of Copenhagen DISEASES database for IL24:
    Melanoma

    10/25 Novoseek disease relationships for IL24 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 80 202 12533668 (8), 8545104 (8), 10942517 (6), 11844832 (6) (see all 75)
    metastatic melanoma 61.6 10 11850799 (2), 12533668 (2), 10942517 (2), 15304100 (1) (see all 6)
    tumors 53.8 120 19357032 (5), 17238830 (4), 9826712 (3), 11844832 (3) (see all 48)
    cancer 51.6 62 8799171 (4), 9826712 (2), 11526239 (2), 12395925 (2) (see all 37)
    lung tumor 50.4 5 12907143 (2), 15093181 (1), 17235306 (1)
    cancer lung 47.5 9 15273727 (2), 11956076 (1), 15709189 (1), 15684712 (1) (see all 8)
    psoriasis 45.8 10 15889129 (5), 17263806 (1), 15667561 (1), 20072629 (1)
    nsclc 35.3 8 11175318 (2), 15194048 (2), 15273727 (1), 15713900 (1) (see all 5)
    nevi 32.5 2 11850799 (1), 17208263 (1)
    pancreatic carcinoma 27.9 5 11526239 (2), 18771346 (1)

    Genetic Association Database (GAD): IL24
    Human Genome Epidemiology (HuGE) Navigator: IL24 (10 documents)

    Export disorders for IL24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL24 gene, integrated from 9 sources (see all 194):
    (articles sorted by number of sources associating them with IL24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. (PubMed id 8545104)1, 2, 3, 9 Jiang H.... Fisher P.B. (1995)
    2. Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. (PubMed id 12533668)1, 4, 9 Ekmekcioglu S....Grimm E.A. (2003)
    3. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. (PubMed id 8799171)1, 3, 9 Jiang H....Fisher P.B. (1996)
    4. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. (PubMed id 9826712)1, 2, 9 Su Z.-Z.... Fisher P.B. (1998)
    5. Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma. (PubMed id 15304100)1, 2, 9 Allen M.... Lucas T. (2004)
    6. Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5. (PubMed id 16313301)1, 2, 9 Allen M....Lucas T. (2005)
    7. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PubMed id 15815689)1, 4 Oleksyk T.K....Smith M.W. (2005)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. (PubMed id 11704829)1, 2 Huang E.Y....Fisher P.B. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11009 HGNC: 11346 AceView: TOSO Ensembl:ENSG00000162892 euGenes: HUgn11009
    ECgene: IL24 Kegg: 11009 H-InvDB: IL24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL24 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_24
    SeattleSNPshttp://pga.gs.washington.edu/data/il24/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL24 gene:
    Search GeneIP for patents involving IL24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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