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IL24 Gene

protein-coding   GIFtS: 63
GCID: GC01P207070

Interleukin 24


(Previous symbol: ST16)
  See IL24-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 241 2     FISP2
ST161 2 3 5     IL10B2
MDA72 3 5     MOB52
IL-4-Induced Secreted Protein1 2     interleukin-242
Suppression Of Tumorigenicity 16 (Melanoma Differentiation)1 2     Melanocyte-Associated Mda-72
Melanoma Differentiation-Associated Gene 7 Protein2 3     IL-243
Melanoma Differentiation Association Protein 71     MDA-73
C49A2     Suppression Of Tumorigenicity 16 Protein3

External Ids:    HGNC: 113461   Entrez Gene: 110092   Ensembl: ENSG000001628927   OMIM: 6041365   UniProtKB: Q130073   

Export aliases for IL24 gene to outside databases

Previous GC identifers: GC01P205730 GC01P202781 GC01P203714 GC01P204154 GC01P203459 GC01P205137 GC01P177769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL24 Gene:
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal
differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various
cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which
correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14
(MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells,
but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have
been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL24 Gene:
IL24 (interleukin 24) is a protein-coding gene. Diseases associated with IL24 include melanoma, and pancreatic cancer. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

Gene Wiki entry for IL24 (Interleukin 24) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL24 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL24 promoter sequence
   Search Chromatin IP Primers for IL24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

IL24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL24 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207070:  view genomic region     (about GC identifiers)

Start:
207,070,788 bp from pter      End:
207,077,484 bp from pter
Size:
6,697 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007 (See protein sequence)
Recommended Name: Interleukin-24 precursor  
Size: 206 amino acids; 23825 Da
Secondary accessions: Q2YHE5 Q53XZ7 Q5YLN8 Q96DB0 Q96KG4
Alternative splicing: 4 isoforms:  Q13007-1   Q13007-2   Q13007-3   Q13007-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL24: NX_Q13007

Explore proteomics data for IL24 at MOPED

Post-translational modifications: 

  • Ubiquitination at Lys-122 promotes proteasomal degradation1
  • Ubiquitination2 at Lys122
  • Glycosylation2 at Asn85, Asn99, Asn126

  • See IL24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001172085.1  NP_001172086.1  NP_001172087.1  NP_006841.1  

    ENSEMBL proteins: 
     ENSP00000375795   ENSP00000294984   ENSP00000356062   ENSP00000356060   ENSP00000418933  

    IL24 Human Recombinant Protein Products:

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    OriGene MassSpec for IL24
    OriGene Custom Protein Services for IL24
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    Novus Biologicals IL24 Proteins
    Novus Biologicals IL24 Lysates
    Sino Biological Recombinant Protein for IL24
    Sino Biological Cell Lysate for IL24
    ProSpec Recombinant Protein for IL24
    Cloud-Clone Corp. Proteins for IL24

     
    Search eBioscience for Proteins for IL24 

     
    antibodies-online proteins for IL24 (30 products) 

     
    antibodies-online peptides for IL24

    IL24 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for IL24
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    antibodies-online antibodies for IL24 (49 products) 

    IL24 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL24
    Cloud-Clone Corp. CLIAs for IL24
    Search eBioscience for ELISAs for IL24 
    antibodies-online kits for IL24 (32 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR020444 IL-24
     IPR012351 4_helix_cytokine_core
     IPR020423 IL-10_CS
     IPR009079 4_helix_cytokine-like_core
     IPR020443 IL-10/19/20/24/26_fam

    Graphical View of Domain Structure for InterPro Entry Q13007

    ProtoNet protein and cluster: Q13007

    1 Blocks protein domain: IPB000098 Interleukin-10

    UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
    Similarity: Belongs to the IL-10 family


    Find genes that share domains with IL24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL24_HUMAN, Q13007
    Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IL24           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL24:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Il24):
     homeostasis/metabolism 

    Find genes that share phenotypes with IL24           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL24: Il24tm1(KOMP)Vlcg Il24tm1Dnax

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL24
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL24
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL24

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL24:
    hsa-mir-205-5p (MIRT005563), hsa-mir-203a (MIRT006858)

    Block miRNA regulation of human, mouse, rat IL24 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IL24:
    hsa-miR-203 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL24 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL24
    Predesigned siRNA for gene silencing in human, mouse, rat IL24

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): IL24 (NM_006850)
    Sino Biological Human cDNA Clone for IL24
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL24

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL24
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL24 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL24_HUMAN, Q13007: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol2
    endoplasmic reticulum2
    mitochondrion2
    nucleus2
    cytoskeleton1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with IL24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL24 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with IL24           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL24 (see all 24)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    2 BioSystems Pathways for IL24
        Senescence and Autophagy
    IL23-mediated signaling events



    2 Kegg Pathways  (Kegg details for IL24):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL24: 
              Th1/Th2 Response in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for IL24 (Q130073 ENSP000002949844) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL20RAQ9UHF43, ENSP000003149764I2D: score=1 STRING: ENSP00000314976
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    IL20RBQ6UXL03I2D: score=1 
    COMMD3ENSP000003660324STRING: ENSP00000366032
    ENSG00000206324ENSP000003827234STRING: ENSP00000382723
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    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS9826712
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0030336negative regulation of cell migration IEA--
    GO:0033136serine phosphorylation of STAT3 protein IEA--

    Find genes that share ontologies with IL24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL24

    5 Novoseek inferred chemical compound relationships for IL24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mezerein 81.9 14 8545104 (3), 10713678 (3), 10942517 (1)
    il 10 63 1 19802007 (1)
    trastuzumab 32.2 2 15300212 (1), 16783343 (1)
    vegf 20.1 3 17235306 (2), 16054437 (1)
    oxygen 0 1 15880678 (1)



    Find genes that share compounds with IL24           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL24 gene (5 alternative transcripts): 
    NM_001185156.1  NM_001185157.1  NM_001185158.1  NM_006850.3  NM_181339.1  

    Unigene Cluster for IL24:

    Interleukin 24
    Hs.58831  [show with all ESTs]
    Unigene Representative Sequence: NM_001185156
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391929 ENST00000294984 ENST00000367095(uc001hex.2 uc001hev.2)
    ENST00000367093(uc001heu.2 uc001hes.2 uc001hew.2) ENST00000491169
    ENST00000480741
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate IL24:
    hsa-miR-203 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL24 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat IL24
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): IL24 (NM_006850)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL24
    Primer
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    OriGene qPCR primer pairs and template standards for IL24
    OriGene qSTAR qPCR primer pairs in human, mouse for IL24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL24
      QuantiTect SYBR Green Assays in human, mouse, rat IL24
      Search QuantiFast Probe-based Assays in human, mouse, rat IL24

    Additional mRNA sequence: 

    AY237723.1 AY641440.1 AY641441.1 BC009681.1 BT007156.1 U16261.1 

    4 DOTS entries:

    DT.453471  DT.40114875  DT.101976578  DT.121352756 

    Selected AceView cDNA sequences (see all 154):

    AA832318 BE674835 CR625287 BP340505 AA991282 AI141006 AA743771 AI365575 
    AA804450 AI762709 BE046111 BE045959 CK904055 BE646438 AA832322 BQ575932 
    AA732513 AW001912 AI434224 AA806272 AI865238 BI966014 AA769190 AA769441 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL24 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                                                                              
    SP2:                                -           -     -                           
    SP3:                    -     -     -                                             
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for IL24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATCACAC
    IL24 Expression
    About this image

    IL24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.58831

    UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
    Tissue specificity: Up-regulated in melanoma cells induced to terminally differentiate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL24: 
              Th1/Th2 Response in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL24
    OriGene qSTAR qPCR primer pairs in human, mouse for IL24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL24
    QuantiTect SYBR Green Assays in human, mouse, rat IL24
    Search QuantiFast Probe-based Assays in human, mouse, rat IL24
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL24 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il241 , 5 interleukin 241, 5 75.87(n)1
    65.1(a)1
      1 (56.89 cM)5
    936721  NM_053095.21  NP_444325.21 
     1308820745 
    lizard
    (Anolis carolinensis)
    Reptilia IL246
    interleukin 24
    31(a)
    1 ↔ 1
    GL343228.1(1949292-1953668)
    zebrafish
    (Danio rerio)
    Actinopterygii il19l6
    interleukin 19 like
    26(a)
    1 → many
    11(21929540-21932984) ENSDARG00000090344


    ENSEMBL Gene Tree for IL24 (if available)
    TreeFam Gene Tree for IL24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL24 gene
    IL192  IL202  
    1 SIMAP similar gene for IL24 using alignment to 3 protein entries:     IL24_HUMAN (see all proteins):
    IL20

    Find genes that share paralogs with IL24           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL24 (see all 234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769879621,2
    C--177771493(-) ACCCT-/CTAGAG 4 -- int10--------
    rs30934181,2
    C,F--207071343(+) AATAC-/AAAAAA 4 -- int13Minor allele frequency- A:0.12NS CSA 88
    rs30934281,2
    C--207074277(+) TATGTT/-ATCAA 4 -- int14Minor allele frequency- -:0.01NS NA 96
    rs30934331,2
    C,F--207075880(+) CCCCC-/CTAAAA 4 -- int14Minor allele frequency- C:0.37NS NA 92
    rs113058001,2
    C,F--207075912(+) ATCACT/-TTTTT 4 -- int1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs741488791,2
    C,F--213874030(+) GGGAAG/CGGGGG 4 -- us2k11Minor allele frequency- C:0.50WA 2
    rs730890851,2
    C--213874039(+) GGAGTG/CGGGGA 4 -- us2k11Minor allele frequency- C:0.50WA 2
    rs38139581,2
    C,F,H--213874064(-) GGCACA/GGCCCC 4 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs1868312271,2
    --213874132(+) GCTATA/GGCCAA 4 -- us2k10--------
    rs730890871,2
    C,F--213874345(+) ACTCCC/TGTTTC 4 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for IL24 (207070788 - 207077484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL24:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468049CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL24
    DNA2.0 Custom Variant and Variant Library Synthesis for IL24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604136    OMIM disorders: --

    3 diseases for IL24:    
    About MalaCards
    melanoma    pancreatic cancer    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for IL24:
    Melanoma

    Find genes that share disorders with IL24           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL24 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 80 202 12533668 (8), 8545104 (8), 10942517 (6), 11844832 (6) (see all 75)
    metastatic melanoma 61.6 10 11850799 (2), 12533668 (2), 10942517 (2), 15304100 (1) (see all 6)
    tumors 53.8 120 19357032 (5), 17238830 (4), 9826712 (3), 11844832 (3) (see all 48)
    cancer 51.6 62 8799171 (4), 9826712 (2), 11526239 (2), 12395925 (2) (see all 37)
    lung tumor 50.4 5 12907143 (2), 15093181 (1), 17235306 (1)
    cancer lung 47.5 9 15273727 (2), 11956076 (1), 15709189 (1), 15684712 (1) (see all 8)
    psoriasis 45.8 10 15889129 (5), 17263806 (1), 15667561 (1), 20072629 (1)
    nsclc 35.3 8 11175318 (2), 15194048 (2), 15273727 (1), 15713900 (1) (see all 5)
    nevi 32.5 2 11850799 (1), 17208263 (1)
    pancreatic carcinoma 27.9 5 11526239 (2), 18771346 (1)

    Genetic Association Database (GAD): IL24
    Human Genome Epidemiology (HuGE) Navigator: IL24 (10 documents)

    Export disorders for IL24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL24 gene, integrated from 10 sources (see all 209):
    (articles sorted by number of sources associating them with IL24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. (PubMed id 8545104)1, 2, 3, 9 Jiang H.... Fisher P.B. (Oncogene 1995)
    2. Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. (PubMed id 12533668)1, 4, 9 Ekmekcioglu S....Grimm E.A. (Mol. Cancer Ther. 2003)
    3. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. (PubMed id 8799171)1, 3, 9 Jiang H....Fisher P.B. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    4. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. (PubMed id 9826712)1, 2, 9 Su Z.-Z.... Fisher P.B. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    5. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PubMed id 17263806)1, 4, 9 Kingo K....Silm H. (Br. J. Dermatol. 2007)
    6. Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma. (PubMed id 15304100)1, 2, 9 Allen M.... Lucas T. (J. Invest. Dermatol. 2004)
    7. Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5. (PubMed id 16313301)1, 2, 9 Allen M.... Lucas T. (Int. J. Immunogenet. 2005)
    8. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PubMed id 19087313)1, 4, 9 Traks T....KA/ks S. (BMC Med. Genet. 2008)
    9. Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24. (PubMed id 23078624)1, 2 Tian H....Zheng J. (amp 2012)
    10. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11009 HGNC: 11346 AceView: TOSO Ensembl:ENSG00000162892 euGenes: HUgn11009
    ECgene: IL24 Kegg: 11009 H-InvDB: IL24

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL24 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_24
    SeattleSNPshttp://pga.gs.washington.edu/data/il24/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IL24 gene:
    Search GeneIP for patents involving IL24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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