Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL24 Gene

protein-coding   GIFtS: 64
GCID: GC01P207070

Interleukin 24


(Previous symbol: ST16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 241 2     FISP2
ST161 2 3 5     IL10B2
MDA72 3 5     MOB52
IL-4-Induced Secreted Protein1 2     interleukin-242
Suppression Of Tumorigenicity 16 (Melanoma Differentiation)1 2     Melanocyte-Associated Mda-72
Melanoma Differentiation-Associated Gene 7 Protein2 3     IL-243
Melanoma Differentiation Association Protein 71     MDA-73
C49A2     Suppression Of Tumorigenicity 16 Protein3

External Ids:    HGNC: 113461   Entrez Gene: 110092   Ensembl: ENSG000001628927   OMIM: 6041365   UniProtKB: Q130073   

Export aliases for IL24 gene to outside databases

Previous GC identifers: GC01P205730 GC01P202781 GC01P203714 GC01P204154 GC01P203459 GC01P205137 GC01P177769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL24 Gene:
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal
differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various
cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which
correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14
(MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells,
but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have
been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL24 Gene: 
IL24 (interleukin 24) is a protein-coding gene. Diseases associated with IL24 include melanoma, and spondyloarthropathy, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

Gene Wiki entry for IL24 (Interleukin 24) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL24 gene promoter:
         AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL24 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

IL24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL24 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207070:  view genomic region     (about GC identifiers)

Start:
207,070,788 bp from pter      End:
207,077,484 bp from pter
Size:
6,697 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007 (See protein sequence)
Recommended Name: Interleukin-24 precursor  
Size: 206 amino acids; 23825 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q2YHE5 Q53XZ7 Q5YLN8 Q96DB0 Q96KG4
Alternative splicing: 4 isoforms:  Q13007-1   Q13007-2   Q13007-3   Q13007-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL24: NX_Q13007

Explore proteomics data for IL24 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13007

  • IL24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL24 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001172085.1  NP_001172086.1  NP_001172087.1  NP_006841.1  

    ENSEMBL proteins: 
     ENSP00000375795   ENSP00000294984   ENSP00000356062   ENSP00000356060   ENSP00000418933  

    Human Recombinant Protein Products for IL24: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL24 (IL-24)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL24
    OriGene Protein Over-expression Lysate for IL24
    OriGene MassSpec for IL24 
    OriGene Custom Protein Services for IL24
    GenScript Custom Purified and Recombinant Proteins Services for IL24
    Novus Biologicals IL24 Proteins
    Novus Biologicals IL24 Lysates
    Sino Biological Recombinant Protein for IL24
    Sino Biological Cell Lysate for IL24 
    ProSpec Recombinant Protein for IL24
    Cloud-Clone Corp. Proteins for IL24 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0005783endoplasmic reticulum IEA--

    IL24 for ontologies           About GeneDecksing



    IL24 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL24 (IL-24)
    OriGene Antibodies for IL24
    OriGene Custom Antibody Services for IL24
    GenScript Custom Superior Antibodies Services for IL24
    Novus Biologicals IL24 Antibodies
    Abcam antibodies for IL24
    Cloud-Clone Corp. Antibodies for IL24 
    ThermoFisher Antibodies for IL24
    LSBio Antibodies in human, mouse, rat for IL24 

    Assay Products for IL24: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL24
    R&D Systems ELISAs for IL24 (IL-24)         (see all)
    GenScript Custom Assay Services for IL24
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL24 
    Cloud-Clone Corp. CLIAs for IL24


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR020444 Interleukin-24
     IPR012351 4_helix_cytokine_core
     IPR020423 Interleukin-10_CS
     IPR009079 4_helix_cytokine-like_core
     IPR020443 Interleukin-10/19/20/24

    Graphical View of Domain Structure for InterPro Entry Q13007

    ProtoNet protein and cluster: Q13007

    1 Blocks protein domain: IPB000098 Interleukin-10

    UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
    Similarity: Belongs to the IL-10 family


    IL24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL24_HUMAN, Q13007
    Function: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
         
    IL24 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL24:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Il24):
     homeostasis/metabolism 

    IL24 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il24tm1Dnax for IL24

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL24 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL24 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL24 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL24:
    hsa-mir-205 (MIRT005563)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL24
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL24:
    hsa-miR-203 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL24 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL24

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL24
    Sirion Biotech Customized adenovirus for overexpression of IL24

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL24 (see all 15)
    OriGene ORF clones in mouse, rat for IL24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): IL24 (NM_006850)
    Sino Biological Human cDNA Clone for IL24
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL24
    Sirion Biotech Customized lentivirus for stable overexpression of IL24 
                         Customized lentivirus expression plasmids for stable overexpression of IL24 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL24
    Search LifeMap BioReagents cell lines for IL24
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL24


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL24 About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for IL24
        Selected targets of C/EBPbeta
    Selected targets of C/EBPalpha

    5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL24 (see all 24)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    2 BioSystems Pathways for IL24
        Senescence and Autophagy
    IL23-mediated signaling events



    2         Kegg Pathways  (Kegg details for IL24):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IL24 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for IL24 (Q130073 ENSP000002949844) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL20RAQ9UHF43, ENSP000003149764I2D: score=1 STRING: ENSP00000314976
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    IL20RBQ6UXL03I2D: score=1 
    COMMD3ENSP000003660324STRING: ENSP00000366032
    ENSG00000206324ENSP000003827234STRING: ENSP00000382723
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0030336negative regulation of cell migration IEA--
    GO:0033136serine phosphorylation of STAT3 protein IEA--

    IL24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL24 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL24

    5 Novoseek inferred chemical compound relationships for IL24 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mezerein 81.9 14 8545104 (3), 10713678 (3), 10942517 (1)
    il 10 63 1 19802007 (1)
    trastuzumab 32.2 2 15300212 (1), 16783343 (1)
    vegf 20.1 3 17235306 (2), 16054437 (1)
    oxygen 0 1 15880678 (1)

    Search CenterWatch for drugs/clinical trials and news about IL24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL24 gene (5 alternative transcripts): 
    NM_001185156.1  NM_001185157.1  NM_001185158.1  NM_006850.3  NM_181339.1  

    Unigene Cluster for IL24:

    Interleukin 24
    Hs.58831  [show with all ESTs]
    Unigene Representative Sequence: NM_001185156
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391929 ENST00000294984 ENST00000367095(uc001hex.2 uc001hev.2)
    ENST00000367093(uc001heu.2 uc001hes.2 uc001hew.2) ENST00000491169
    ENST00000480741
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL24
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL24:
    hsa-miR-203 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL24 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL24
    Clone
    Products:
         
    OriGene clones in human, mouse for IL24 (see all 15)
    OriGene ORF clones in mouse, rat for IL24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): IL24 (NM_006850)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL24
    Sirion Biotech Customized lentivirus for stable overexpression of IL24 
                         Customized lentivirus expression plasmids for stable overexpression of IL24 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL24
    OriGene qSTAR qPCR primer pairs in human, mouse for IL24
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL24
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL24
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL24

    Additional mRNA sequence: 

    AY237723.1 AY641440.1 AY641441.1 BC009681.1 BT007156.1 U16261.1 

    4 DOTS entries:

    DT.453471  DT.40114875  DT.101976578  DT.121352756 

    24/154 AceView cDNA sequences (see all 154):

    AI399732 CB158779 NM_005449 AW571597 AI638155 AA281635 BP340505 AI760350 
    AW768503 BE646438 BQ707299 BP338035 AA806272 AA991282 AA743771 BI966014 
    BE674835 AW242211 CK904055 BE046111 AI479031 BF975138 AA804450 AA832318 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL24 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:                                                                              
    SP2:                                -           -     -                           
    SP3:                    -     -     -                                             
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for IL24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATCACAC
    IL24 Expression
    About this image


    See IL24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL24

    SOURCE GeneReport for Unigene cluster: Hs.58831

    UniProtKB/Swiss-Prot: IL24_HUMAN, Q13007
    Tissue specificity: Up-regulated in melanoma cells induced to terminally differentiate

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL24: 
              Th1/Th2 Response in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL24
    OriGene qSTAR qPCR primer pairs in human, mouse for IL24
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL24
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL24
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL24
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL24 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il241 , 5 interleukin 241, 5 76.52(n)1
    66.13(a)1
      1 (56.89 cM)5
    936721  NM_053095.21  NP_444325.21 
     1308820745 
    lizard
    (Anolis carolinensis)
    Reptilia IL246
    Uncharacterized protein
    33(a)
    1 ↔ 1
    GL343228.1(1949292-1953668)
    zebrafish
    (Danio rerio)
    Actinopterygii il346
    interleukin 34
    30(a)
    1 → many
    11(21929589-21932934)


    ENSEMBL Gene Tree for IL24 (if available)
    TreeFam Gene Tree for IL24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL24 gene
    IL192  IL202  
    1 SIMAP similar gene for IL24 using alignment to 3 protein entries:     IL24_HUMAN (see all proteins):
    IL20

    IL24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/234 SNPs in IL24 are shown (see all 234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769879621,2
    C--177771493(-) ACCCT-/CTAGAG 4 -- int10--------
    rs30934181,2
    C,F--207071343(+) AATAC-/AAAAAA 4 -- int13Minor allele frequency- A:0.12NS CSA 88
    rs30934281,2
    C--207074277(+) TATGTT/-ATCAA 4 -- int14Minor allele frequency- -:0.01NS NA 96
    rs30934331,2
    C,F--207075880(+) CCCCC-/CTAAAA 4 -- int14Minor allele frequency- C:0.37NS NA 92
    rs113058001,2
    C,F--207075912(+) ATCACT/-TTTTT 4 -- int1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs741488791,2
    C,F--213874030(+) GGGAAG/CGGGGG 4 -- us2k11Minor allele frequency- C:0.50WA 2
    rs730890851,2
    C--213874039(+) GGAGTG/CGGGGA 4 -- us2k11Minor allele frequency- C:0.50WA 2
    rs38139581,2
    C,F,H--213874064(-) GGCACA/GGCCCC 4 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs1868312271,2
    --213874132(+) GCTATA/GGCCAA 4 -- us2k10--------
    rs730890871,2
    C,F--213874345(+) ACTCCC/TGTTTC 4 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for IL24 (207070788 - 207077484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL24:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv468049CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL24
    DNA2.0 Custom Variant and Variant Library Synthesis for IL24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604136    OMIM disorders: --

    20/32 diseases for IL24 (see all 32):    About MalaCards
    melanoma    spondyloarthropathy    major depressive disorder    keloids
    pancreatic cancer    psoriasis    influenza    bronchiolitis
    chronic lymphocytic leukemia    malignant glioma    skin disease    pancreatitis
    inflammatory bowel disease    periodontitis    prostate cancer    lung cancer
    ovarian cancer    cervical cancer    prostatitis    glioblastoma

    1 disease from the University of Copenhagen DISEASES database for IL24:
    Melanoma

    IL24 for disorders           About GeneDecksing

    10/25 Novoseek inferred disease relationships for IL24 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 80 202 12533668 (8), 8545104 (8), 10942517 (6), 11844832 (6) (see all 75)
    metastatic melanoma 61.6 10 11850799 (2), 12533668 (2), 10942517 (2), 15304100 (1) (see all 6)
    tumors 53.8 120 19357032 (5), 17238830 (4), 9826712 (3), 11844832 (3) (see all 48)
    cancer 51.6 62 8799171 (4), 9826712 (2), 11526239 (2), 12395925 (2) (see all 37)
    lung tumor 50.4 5 12907143 (2), 15093181 (1), 17235306 (1)
    cancer lung 47.5 9 15273727 (2), 11956076 (1), 15709189 (1), 15684712 (1) (see all 8)
    psoriasis 45.8 10 15889129 (5), 17263806 (1), 15667561 (1), 20072629 (1)
    nsclc 35.3 8 11175318 (2), 15194048 (2), 15273727 (1), 15713900 (1) (see all 5)
    nevi 32.5 2 11850799 (1), 17208263 (1)
    pancreatic carcinoma 27.9 5 11526239 (2), 18771346 (1)

    Genetic Association Database (GAD): IL24
    Human Genome Epidemiology (HuGE) Navigator: IL24 (10 documents)

    Export disorders for IL24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL24 gene, integrated from 9 sources (see all 201):
    (articles sorted by number of sources associating them with IL24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. (PubMed id 8545104)1, 2, 3, 9 Jiang H.... Fisher P.B. (1995)
    2. Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. (PubMed id 12533668)1, 4, 9 Ekmekcioglu S....Grimm E.A. (2003)
    3. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. (PubMed id 8799171)1, 3, 9 Jiang H....Fisher P.B. (1996)
    4. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. (PubMed id 9826712)1, 2, 9 Su Z.-Z.... Fisher P.B. (1998)
    5. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PubMed id 17263806)1, 4, 9 Kingo K....Silm H. (2007)
    6. Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma. (PubMed id 15304100)1, 2, 9 Allen M.... Lucas T. (2004)
    7. Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5. (PubMed id 16313301)1, 2, 9 Allen M....Lucas T. (2005)
    8. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PubMed id 19087313)1, 4, 9 Traks T....KA/ks S. (2008)
    9. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    10. Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents. (PubMed id 20976276)1, 4 Shrestha S....Tang J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11009 HGNC: 11346 AceView: TOSO Ensembl:ENSG00000162892 euGenes: HUgn11009
    ECgene: IL24 Kegg: 11009 H-InvDB: IL24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL24 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_24
    SeattleSNPshttp://pga.gs.washington.edu/data/il24/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL24 gene:
    Search GeneIP for patents involving IL24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IL24 (IL-24)   Browse Cell Culture Products  
     ELISAs for IL24 (IL-24)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IL24 (IL-24)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for IL24 (IL-24)  
     OriGene Antibodies for IL24   OriGene RNAi products in human, mouse, rat for IL24  
     OriGene qPCR primer pairs and template standards for IL24   OriGene Protein Over-expression Lysate for IL24  
     OriGene MassSpec something-or-other for IL24   OriGene clones in human, mouse for IL24  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL24   OriGene Purified Protein for IL24  
     OriGene ORF clones in mouse, rat for IL24   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL24   OriGene Custom Protein Services for IL24  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL24
     QIAGEN SeqTarget long-range PCR primers for resequencing IL24
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL24
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL24
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL24
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL24
     GenScript Custom Purified and Recombinant Proteins Services for IL24 GenScript cDNA clones with any tag delivered in your preferred vector for IL24
     GenScript Custom Assay Services for IL24 GenScript Custom Superior Antibodies Services for IL24
     GenScript Custom overexpressing Cell Line Services for IL24 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IL24 promoter
     Search Chromatin IP Primers for IL24
     RT2 qPCR Primer Assay in human, mouse, rat IL24
     GNC Network for IL24
     SABiosciences PCR Arrays including human, mouse, rat IL24
     Search Tocris compounds for IL24
     Proteins and Antibodies for IL24
     Cell Lysates for IL24
     cDNA Clones for IL24
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IL24 antibodies
     IL24 proteins
     IL24 lysates
     Antibodies for IL24
     See all of Abcam's Antibodies, Kits and Proteins for IL24
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IL24




     Proteins for IL24
     Antibodies for IL24
     ELISAs for IL24
     CLIAs for IL24
     Search LifeMap BioReagents cell lines for IL24
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL24
     SwitchGear 3'UTR luciferase reporter plasmids for IL24
     SwitchGear Promoter luciferase reporter plasmids for IL24
     ThermoFisher Antibodies for IL24
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL24
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IL24
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL24
    Customized:
     lentivirus for stable overexpression of IL24
     lentivirus expression plasmids for stable overexpression of IL24
     adenovirus for overexpression of IL24
     LSBio Antibodies in human, mouse, rat for IL24
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL24 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4