Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL24 Gene

Aliases for IL24 Gene

  • Interleukin 24 2 3
  • Suppression Of Tumorigenicity 16 (Melanoma Differentiation) 2 3
  • Melanoma Differentiation-Associated Gene 7 Protein 3 4
  • IL-4-Induced Secreted Protein 2 3
  • ST16 3 4
  • MDA7 3 4
  • Melanoma Differentiation Association Protein 7 2
  • Suppression Of Tumorigenicity 16 Protein 4
  • Melanocyte-Associated Mda-7 3
  • IL10B 3
  • IL-24 4
  • MDA-7 4
  • C49A 3
  • FISP 3
  • MOB5 3

External Ids for IL24 Gene

Previous HGNC Symbols for IL24 Gene

  • ST16

Previous GeneCards Identifiers for IL24 Gene

  • GC01P205730
  • GC01P202781
  • GC01P203714
  • GC01P204154
  • GC01P203459
  • GC01P205137
  • GC01P207070
  • GC01P177769

Summaries for IL24 Gene

Entrez Gene Summary for IL24 Gene

  • This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL24 Gene

IL24 (Interleukin 24) is a Protein Coding gene. Diseases associated with IL24 include petrous apex meningioma and subclavian steal syndrome. Among its related pathways are TGF-Beta Pathway and Akt Signaling. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot for IL24 Gene

  • Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

Gene Wiki entry for IL24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL24 Gene

Genomics for IL24 Gene

Regulatory Elements for IL24 Gene

Genomic Location for IL24 Gene

Chromosome:
1
Start:
206,897,098 bp from pter
End:
206,904,139 bp from pter
Size:
7,042 bases
Orientation:
Plus strand

Genomic View for IL24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL24 Gene

Proteins for IL24 Gene

  • Protein details for IL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13007-IL24_HUMAN
    Recommended name:
    Interleukin-24
    Protein Accession:
    Q13007
    Secondary Accessions:
    • Q2YHE5
    • Q53XZ7
    • Q5YLN8
    • Q96DB0
    • Q96KG4

    Protein attributes for IL24 Gene

    Size:
    206 amino acids
    Molecular mass:
    23825 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL24 Gene

Proteomics data for IL24 Gene at MOPED

Post-translational modifications for IL24 Gene

  • Ubiquitination at Lys-122 promotes proteasomal degradation.
  • Ubiquitination at Lys 122
  • Glycosylation at Asn 85, Asn 99, and Asn 126
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IL24 Gene

Domains & Families for IL24 Gene

Gene Families for IL24 Gene

Suggested Antigen Peptide Sequences for IL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13007

UniProtKB/Swiss-Prot:

IL24_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL24: view

Function for IL24 Gene

Molecular function for IL24 Gene

UniProtKB/Swiss-Prot Function:
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation

Gene Ontology (GO) - Molecular Function for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005515 protein binding IPI 25640309
genes like me logo Genes that share ontologies with IL24: view
genes like me logo Genes that share phenotypes with IL24: view

Animal Models for IL24 Gene

MGI Knock Outs for IL24:

Animal Model Products

miRNA for IL24 Gene

miRTarBase miRNAs that target IL24

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL24

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL24 Gene

Localization for IL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL24 Gene COMPARTMENTS Subcellular localization image for IL24 gene
Compartment Confidence
extracellular 3
cytosol 2
endoplasmic reticulum 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL24: view

Pathways & Interactions for IL24 Gene

genes like me logo Genes that share pathways with IL24: view

Pathways by source for IL24 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with IL24: view

No data available for SIGNOR curated interactions for IL24 Gene

Drugs & Compounds for IL24 Gene

(2) Drugs for IL24 Gene - From: NovoSeek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Trastuzumab Approved, Investigational Pharma HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 688
INGN 242 Pharma 0

(4) Additional Compounds for IL24 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IL 10
MEZEREIN
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
VEGF
genes like me logo Genes that share compounds with IL24: view

Transcripts for IL24 Gene

Unigene Clusters for IL24 Gene

Interleukin 24:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL24

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for IL24 Gene

GeneLoc Exon Structure for
IL24
ECgene alternative splicing isoforms for
IL24

Expression for IL24 Gene

mRNA expression in normal human tissues for IL24 Gene

mRNA differential expression in normal tissues according to GTEx for IL24 Gene

This gene is overexpressed in Spleen (x11.8), Whole Blood (x10.0), and Small Intestine - Terminal Ileum (x6.0).

Protein differential expression in normal tissues from HIPED for IL24 Gene

This gene is overexpressed in Platelet (62.6) and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL24 Gene



SOURCE GeneReport for Unigene cluster for IL24 Gene Hs.58831

mRNA Expression by UniProt/SwissProt for IL24 Gene

Q13007-IL24_HUMAN
Tissue specificity: Up-regulated in melanoma cells induced to terminally differentiate
genes like me logo Genes that share expression patterns with IL24: view

Protein tissue co-expression partners for IL24 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL24 Gene

Orthologs for IL24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL24 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IL24 35
  • 78.01 (n)
  • 66.49 (a)
IL24 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il24 35
  • 75.87 (n)
  • 65.1 (a)
Il24 16
Il24 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL24 35
  • 99.52 (n)
  • 98.55 (a)
IL24 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il24 35
  • 79.24 (n)
  • 66.29 (a)
cow
(Bos Taurus)
Mammalia IL24 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL24 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL24 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL24 36
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il19l 36
  • 26 (a)
OneToMany
Species with no ortholog for IL24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL24 Gene

ENSEMBL:
Gene Tree for IL24 (if available)
TreeFam:
Gene Tree for IL24 (if available)

Paralogs for IL24 Gene

Paralogs for IL24 Gene

(1) SIMAP similar genes for IL24 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL24: view

Variants for IL24 Gene

Sequence variations from dbSNP and Humsavar for IL24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs192646 -- 206,900,565(-) ACCTT(C/T)CCCAT intron-variant
rs291107 -- 206,901,826(-) GGGCT(A/G)CCTCC intron-variant
rs291108 -- 206,899,076(-) TGCCC(G/T)TCCAC intron-variant
rs291109 -- 206,898,806(-) GGAGC(A/G)AGGGG intron-variant
rs1150254 -- 206,899,170(-) TGCTA(A/G)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL24 Gene

Variant ID Type Subtype PubMed ID
nsv468049 CNV Loss 19166990

Variation tolerance for IL24 Gene

Residual Variation Intolerance Score: 51.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.81; 86.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL24 Gene

HapMap Linkage Disequilibrium report
IL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL24 Gene

Disorders for IL24 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL24 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
petrous apex meningioma
  • meningioma of the petrous ridge
subclavian steal syndrome
  • subclavian artery stenosis
blount's disease
  • blount disease
chondromalacia patellae
  • softening of articular cartilage of patella
chorioangioma
  • hemangioma
- elite association
Search IL24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL24

Genetic Association Database (GAD)
IL24
Human Genome Epidemiology (HuGE) Navigator
IL24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL24
genes like me logo Genes that share disorders with IL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL24 Gene

Publications for IL24 Gene

  1. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. (PMID: 8799171) Jiang H. … Fisher P.B. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 23 67
  2. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. (PMID: 8545104) Jiang H. … Fisher P.B. (Oncogene 1995) 2 23 67
  3. Cytokine expression and signaling in drug-induced cellular senescence. (PMID: 19802007) Novakova Z. … Hodny Z. (Oncogene 2010) 23 67
  4. Recombinant human interleukin-24 suppresses gastric carcinoma cell growth in vitro and in vivo. (PMID: 19916746) Yan S. … Yang J. (Cancer Invest. 2010) 23 67
  5. Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. (PMID: 19965640) Maarof G. … Dalloul A. (Blood 2010) 23 67

Products for IL24 Gene

Sources for IL24 Gene

Back to Top

Content