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Aliases for IL24 Gene

Aliases for IL24 Gene

  • Interleukin 24 2 3 5
  • Suppression Of Tumorigenicity 16 (Melanoma Differentiation) 2 3
  • Melanoma Differentiation-Associated Gene 7 Protein 3 4
  • IL-4-Induced Secreted Protein 2 3
  • ST16 3 4
  • MDA7 3 4
  • Melanoma Differentiation Association Protein 7 2
  • Suppression Of Tumorigenicity 16 Protein 4
  • Melanocyte-Associated Mda-7 3
  • Interleukin-24 3
  • IL10B 3
  • IL-24 4
  • MDA-7 4
  • C49A 3
  • FISP 3
  • MOB5 3

External Ids for IL24 Gene

Previous HGNC Symbols for IL24 Gene

  • ST16

Previous GeneCards Identifiers for IL24 Gene

  • GC01P205730
  • GC01P202781
  • GC01P203714
  • GC01P204154
  • GC01P203459
  • GC01P205137
  • GC01P207070
  • GC01P177769

Summaries for IL24 Gene

Entrez Gene Summary for IL24 Gene

  • This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL24 Gene

IL24 (Interleukin 24) is a Protein Coding gene. Diseases associated with IL24 include Melanoma and Subclavian Steal Syndrome. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.

UniProtKB/Swiss-Prot for IL24 Gene

  • Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Gene Wiki entry for IL24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL24 Gene

Genomics for IL24 Gene

Regulatory Elements for IL24 Gene

Enhancers for IL24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G206768 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10 -126.2 -126174 4.6 HDGF PKNOX1 ATF1 YY1 TCF12 GATA2 ZNF143 JUNB TBX21 KAT8 IL19 MAPKAPK2 IL24 IL20 IL10 C4BPB RASSF5 ENSG00000284486
GH01G206722 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -173.4 -173411 2.2 TBP SIN3A BRCA1 RAD21 RFX5 YY1 RCOR1 FOS ZHX1 DEK MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 GC01M206749
GH01G206757 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -139.4 -139376 1.1 BCOR CTCF ASH2L ZMYM3 ZBTB40 ARID3A POLR2A EED ETV6 RELB IL19 IL24 IL20 FCMR IL10 IKBKE RASSF5 GC01M206760 LOC105372877
GH01G207004 1.5 Ensembl ENCODE dbSUPER 10.7 +110.7 110706 7.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A BRCA1 ZNF2 ZNF766 GATA2 PIGR FCMR FCAMR IL24 IL20 PFKFB2 MAPKAPK2 IL19 C4BPB TRP-TGG5-1
GH01G206671 1.6 Ensembl ENCODE dbSUPER 9.8 -223.4 -223378 4.7 HDGF FOXA2 PKNOX1 CREB3L1 ARNT YY1 ZNF766 FOS KLF13 REST EIF2D RASSF5 C1orf147 IL24 IL19 DYRK3 MAPKAPK2 IKBKE LOC105372875 PIR60472
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL24 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL24 Gene

Chromosome:
1
Start:
206,897,098 bp from pter
End:
206,904,139 bp from pter
Size:
7,042 bases
Orientation:
Plus strand

Genomic View for IL24 Gene

Genes around IL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL24 Gene

Proteins for IL24 Gene

  • Protein details for IL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13007-IL24_HUMAN
    Recommended name:
    Interleukin-24
    Protein Accession:
    Q13007
    Secondary Accessions:
    • Q2YHE5
    • Q53XZ7
    • Q5YLN8
    • Q96DB0
    • Q96KG4

    Protein attributes for IL24 Gene

    Size:
    206 amino acids
    Molecular mass:
    23825 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL24 Gene

Post-translational modifications for IL24 Gene

  • Ubiquitination at Lys-122 promotes proteasomal degradation.
  • Ubiquitination at isoforms=2122
  • Glycosylation at posLast=8585, posLast=9999, and isoforms=2126
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IL24

Protein Products

Assay Products

No data available for DME Specific Peptides for IL24 Gene

Domains & Families for IL24 Gene

Gene Families for IL24 Gene

Protein Domains for IL24 Gene

Suggested Antigen Peptide Sequences for IL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13007

UniProtKB/Swiss-Prot:

IL24_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL24: view

Function for IL24 Gene

Molecular function for IL24 Gene

UniProtKB/Swiss-Prot Function:
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Gene Ontology (GO) - Molecular Function for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25640309
genes like me logo Genes that share ontologies with IL24: view
genes like me logo Genes that share phenotypes with IL24: view

Animal Models for IL24 Gene

MGI Knock Outs for IL24:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL24

CRISPR Products

miRNA for IL24 Gene

miRTarBase miRNAs that target IL24

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL24 Gene

Localization for IL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL24 gene
Compartment Confidence
extracellular 5
mitochondrion 3
nucleus 3
cytosol 3
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL24: view

Pathways & Interactions for IL24 Gene

genes like me logo Genes that share pathways with IL24: view

Gene Ontology (GO) - Biological Process for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA,TAS --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0030336 negative regulation of cell migration IEA --
GO:0033136 serine phosphorylation of STAT3 protein IEA --
genes like me logo Genes that share ontologies with IL24: view

No data available for SIGNOR curated interactions for IL24 Gene

Drugs & Compounds for IL24 Gene

(3) Drugs for IL24 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
INGN 242 Pharma 0

(3) Additional Compounds for IL24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL24: view

Transcripts for IL24 Gene

Unigene Clusters for IL24 Gene

Interleukin 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for IL24 Gene

GeneLoc Exon Structure for
IL24
ECgene alternative splicing isoforms for
IL24

Expression for IL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL24 Gene

mRNA differential expression in normal tissues according to GTEx for IL24 Gene

This gene is overexpressed in Spleen (x11.8), Whole Blood (x10.0), and Small Intestine - Terminal Ileum (x6.0).

Protein differential expression in normal tissues from HIPED for IL24 Gene

This gene is overexpressed in Platelet (62.6) and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL24 Gene



Protein tissue co-expression partners for IL24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL24 Gene:

IL24

SOURCE GeneReport for Unigene cluster for IL24 Gene:

Hs.58831

mRNA Expression by UniProt/SwissProt for IL24 Gene:

Q13007-IL24_HUMAN
Tissue specificity: Up-regulated in melanoma cells induced to terminally differentiate.

Evidence on tissue expression from TISSUES for IL24 Gene

  • Lung(4.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with IL24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL24 Gene

Orthologs for IL24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL24 35 34
  • 99.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il24 34
  • 79.24 (n)
dog
(Canis familiaris)
Mammalia IL24 35 34
  • 78.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il24 35 16 34
  • 75.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL24 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL24 35
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL24 35
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL24 35
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il19l 35
  • 26 (a)
OneToMany
Species where no ortholog for IL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL24 Gene

ENSEMBL:
Gene Tree for IL24 (if available)
TreeFam:
Gene Tree for IL24 (if available)

Paralogs for IL24 Gene

Paralogs for IL24 Gene

(1) SIMAP similar genes for IL24 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL24: view

Variants for IL24 Gene

Sequence variations from dbSNP and Humsavar for IL24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001396694 -- 206,903,397(+) TTACC(C/G)CTCAC utr-variant-3-prime
rs1001519273 -- 206,897,369(+) CCTTT(C/T)TCCAC upstream-variant-2KB
rs1001635337 -- 206,903,727(+) CCTCC(-/T)TTTTT utr-variant-3-prime
rs1001855060 -- 206,904,222(+) TTTGG(A/G)TGAAT downstream-variant-500B, utr-variant-3-prime
rs1002522050 -- 206,895,919(+) ACACT(C/G)AGTAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL24 Gene

Variant ID Type Subtype PubMed ID
nsv1010486 CNV gain 25217958
nsv468049 CNV loss 19166990
nsv549071 CNV loss 21841781

Variation tolerance for IL24 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.81; 86.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL24 Gene

Disorders for IL24 Gene

MalaCards: The human disease database

(9) MalaCards diseases for IL24 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
subclavian steal syndrome
  • subclavian artery stenosis
petrous apex meningioma
  • meningioma of the petrous ridge
blount's disease
  • blount disease
patella, chondromalacia of
  • chondromalacia patellae
- elite association - COSMIC cancer census association via MalaCards
Search IL24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL24

Genetic Association Database (GAD)
IL24
Human Genome Epidemiology (HuGE) Navigator
IL24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL24
genes like me logo Genes that share disorders with IL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL24 Gene

Publications for IL24 Gene

  1. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. (PMID: 8545104) Jiang H. … Fisher P.B. (Oncogene 1995) 2 3 4 22 64
  2. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T. … KA/ks S. (BMC Med. Genet. 2008) 3 22 46 64
  3. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K. … Silm H. (Br. J. Dermatol. 2007) 3 22 46 64
  4. Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5. (PMID: 16313301) Allen M. … Lucas T. (Int. J. Immunogenet. 2005) 3 4 22 64
  5. Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma. (PMID: 15304100) Allen M. … Lucas T. (J. Invest. Dermatol. 2004) 3 4 22 64

Products for IL24 Gene

Sources for IL24 Gene

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