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IL23R Gene

protein-coding   GIFtS: 59
GCID: GC01P067632

Interleukin 23 Receptor

  See IL23R-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 23 Receptor1 2
IL-23 Receptor2 3
Interleukin-23 Receptor2
IL-23R3
IBD175

External Ids:    HGNC: 191001   Entrez Gene: 1492332   Ensembl: ENSG000001625947   OMIM: 6075625   UniProtKB: Q5VWK53   

Export aliases for IL23R gene to outside databases

Previous GC identifers: GC01P066563 GC01P066989 GC01P067002 GC01P067344 GC01P065740


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL23R Gene:
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor
molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively
with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
(provided by RefSeq, Jul 2008)

GeneCards Summary for IL23R Gene:
IL23R (interleukin 23 receptor) is a protein-coding gene. Diseases associated with IL23R include psoriasis, protection against, and inflammatory bowel disease 17, protection against. GO annotations related to this gene include interleukin-23 receptor activity and interleukin-12 receptor binding.

UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells
and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling
cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in
peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for
tumorigenesis

Gene Wiki entry for IL23R (Interleukin-23 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IL23R gene promoter:
         Bach1   AP-1   GATA-1   MEF-2A   PPAR-alpha   IRF-2   Nkx6-1   aMEF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL23R promoter sequence
   Search Chromatin IP Primers for IL23R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL23R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

IL23R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL23R gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P067632:  view genomic region     (about GC identifiers)

Start:
67,632,083 bp from pter      End:
67,725,662 bp from pter
Size:
93,580 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5 (See protein sequence)
Recommended Name: Interleukin-23 receptor precursor  
Size: 629 amino acids; 71722 Da
Subunit: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with
JAK2 and in presence of IL23 with STAT3
Sequence caution: Sequence=AAH16829.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH70408.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI22679.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JGX4 Q4VGP1 Q4VGP2 Q4VGP3 Q4VGP4 Q4VGP5 Q4VGP6 Q5VWK7 Q8IW84 Q8NFQ9
Q96AS1
Alternative splicing: 7 isoforms:  Q5VWK5-1   Q5VWK5-2   Q5VWK5-3   Q5VWK5-4   Q5VWK5-5   Q5VWK5-6   Q5VWK5-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL23R: NX_Q5VWK5

Explore proteomics data for IL23R at MOPED

Post-translational modifications: 

  • Phosphorylated in response to IL231
  • Glycosylation2 at Asn29, Asn47, Asn81, Asn141, Asn180, Asn232, Asn262, Asn273
  • Modification sites at PhosphoSitePlus

  • See IL23R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653302.2  
    ENSEMBL proteins: 
     ENSP00000321345   ENSP00000387640   ENSP00000360041   ENSP00000378652  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 23 receptor
    IL-12 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q5VWK5

    ProtoNet protein and cluster: Q5VWK5

    UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 2 fibronectin type-III domains


    Find genes that share domains with IL23R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL23R_HUMAN, Q5VWK5
    Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells
    and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling
    cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in
    peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for
    tumorigenesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005143contributes to interleukin-12 receptor binding IPI12023369
    GO:0005515protein binding ----
    GO:0042019contributes to interleukin-23 binding IPI12023369
    GO:0042020contributes to interleukin-23 receptor activity IDA12023369
         
    Find genes that share ontologies with IL23R           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il23r):
     hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with IL23R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL23R: Il23rtm1.2Trin Il23rtm1.1Kuch Il23rtm1Dnax

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL23R
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL23R_HUMAN, Q5VWK5: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043235receptor complex IDA--
    GO:0072536interleukin-23 receptor complex IDA12023369

    Find genes that share ontologies with IL23R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL23R About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    5Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47


    Find genes that share SuperPaths with IL23R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL23R
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL23R (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    3 GeneGo (Thomson Reuters) Pathways for IL23R
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Immune response IL-23 signaling pathway

    1 BioSystems Pathway for IL23R
        IL23-mediated signaling events



    3 Kegg Pathways  (Kegg details for IL23R):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Inflammatory bowel disease (IBD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL23R: 
              Th17 Response in human mouse rat
              Insulin Resistance in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL23R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL23R (Q5VWK53 ENSP000003213454) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL12BP294603, ENSP000002312284I2D: score=1 STRING: ENSP00000231228
    IL12RB1P427013, ENSP000003144254I2D: score=3 STRING: ENSP00000314425
    IL23AQ9NPF73, ENSP000002285344I2D: score=3 STRING: ENSP00000228534
    JAK2O606743, ENSP000003710674I2D: score=1 STRING: ENSP00000371067
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity ISS--
    GO:0002230positive regulation of defense response to virus by host ISS--
    GO:0002827positive regulation of T-helper 1 type immune response ISS--
    GO:0006954inflammatory response IEA--
    GO:0010535positive regulation of activation of JAK2 kinase activity IC12023369

    Find genes that share ontologies with IL23R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL23R



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL23R gene: 
    NM_144701.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347310(uc010opo.1 uc010opq.1 uc010opr.1 uc009waz.3 uc001ddo.3 uc010opi.2 uc010opj.2 uc010opk.2 uc010opl.2 uc010opm.2 uc001ddq.3 uc010opn.2 uc001ddr.3 uc010ops.2 uc010opt.2 uc010opu.2 uc010opv.2 uc010opw.2 uc010opx.2 uc010opy.2 uc010opz.2 uc010oqa.2 uc010oqb.2 uc010oqc.2 uc010oqd.2 uc010oqe.2 uc010oqg.2 uc010oqh.2 uc010oqf.2)
    ENST00000425614 ENST00000473881 ENST00000371002(uc001ddp.2 uc010opp.1)
    ENST00000395227(uc001dds.3 uc001ddt.3)
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    18 AceView cDNA sequences:

    BC040720 AF461422 NM_144701 BC016829 BQ228535 BU172309 BF211696 BF210400 
    BE622106 BF183992 BF238439 BU570522 BF238869 BE279086 CD708943 BF209716 
    BF185326 BF212748 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL23R (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                  -     -                                                   
    SP2:                                                  -     -                 -                                 
    SP3:                                                  -     -                 -           -                     
    SP4:                                      -           -     -                                                   
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for IL23R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL23R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTTTAT
    IL23R Expression
    About this image

    IL23R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL23R Protein Expression

    UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
    Tissue specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed
    in NK cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL23R: 
              Th17 Response in human mouse rat
              Insulin Resistance in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL23R gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il23r1 , 5 interleukin 23 receptor1, 5 78.28(n)1
    69.5(a)1
      6 (30.85 cM)5
    2095901  NM_144548.11  NP_653131.21 
     674229325 
    chicken
    (Gallus gallus)
    Aves IL23R1 interleukin 23 receptor 48.61(n)
    36.59(a)
      424704  XM_004936877.1  XP_004936934.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL23R6
    interleukin 23 receptor
    33(a)
    1 ↔ 1
    GL343410.1(12724-51452)
    zebrafish
    (Danio rerio)
    Actinopterygii il23r6
    interleukin 23 receptor
    10(a)
    1 ↔ 1
    6(34929736-34956755) ENSDARG00000052158


    ENSEMBL Gene Tree for IL23R (if available)
    TreeFam Gene Tree for IL23R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL23R gene
    1 SIMAP similar gene for IL23R using alignment to 25 protein entries:     IL23R_HUMAN (see all proteins):
    IL6ST

    Find genes that share paralogs with IL23R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL23R (see all 2862)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112090261,2,,4
    C,F,Hother167778667(+) ATTCCG/AAACTG 2 /Q /R mis124Minor allele frequency- A:0.04NA EU NS EA CSA 7981
    rs584808551,2
    C--65753625(-) TTTTT-/A/TAAAGG 1 -- int10--------
    rs774218761,2
    C--65754079(-) CAAAT-/G/TGTAAA 1 -- int10--------
    rs3710027361,2
    C--65764502(+) AAACC-/AAAAAA 1 -- int10--------
    rs30529571,2
    C--65803022(+) TTTTT-/T/TT/T
    TT
    /TTTTT
    GACAG
    2 -- int1 cds10--------
    rs1386515991,2
    --65803674(+) TTTCT-/CTCTC 
            
    TTTCT
    1 -- int10--------
    rs2015855661,2
    C--65803676(+) TCTCTC/TTCTTT 1 -- int10--------
    rs672444981,2
    C--65809541(+) GTGTG-/TG    
       
    /TGTG
    AGATT
    1 -- int11NA 2
    rs340471511,2
    C--65827037(+) AAAAA-/A/AA  
            
    GGAAA
    1 -- int11NA 2
    rs57748621,2
    C--65830000(+) tatatAT/-tCTCA 1 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for IL23R (67632083 - 67725662 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IL23R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1243CNV Loss18451855
    nsv482980CNV Loss15286789
    nsv461751CNV Loss19166990
    nsv461762CNV Gain19166990

    Human Gene Mutation Database (HGMD): IL23R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL23R
    DNA2.0 Custom Variant and Variant Library Synthesis for IL23R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607562   
    OMIM disorders: 612261  605606  
    UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
  • Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the
    gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis
    phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most
    frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may
    contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the
    inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not
    observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Psoriasis 7 (PSORS7) [MIM:605606]: A common, chronic inflammatory disease of the skin with multifactorial
    etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions
    are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and
    epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 9 diseases for IL23R:    
    About MalaCards
    psoriasis, protection against    inflammatory bowel disease 17, protection against    idiopathic achalasia    juvenile psoriatic arthritis
    behcet's disease    psoriatic arthritis    achalasia    ankylosing spondylitis
    inflammatory bowel disease

    3 diseases from the University of Copenhagen DISEASES database for IL23R:
    Crohn's disease     Psoriasis     Ankylosing spondylitis

    Find genes that share disorders with IL23R           About GenesLikeMe

    5 Novoseek inferred disease relationships for IL23R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory bowel diseases 74.4 18 18698678 (1), 17068223 (1), 17618837 (1), 18164077 (1) (see all 13)
    psoriasis 72.8 33 18650833 (4), 19175939 (4), 19035472 (2), 18383363 (2) (see all 12)
    colitis ulcerative 55.5 5 17068223 (1), 19175939 (1), 20192940 (1)
    rheumatoid arthritis 48.4 9 17606463 (2), 17678723 (2), 19021011 (1), 19034457 (1) (see all 6)
    autoimmune diseases 39.8 9 19522770 (2), 17606463 (1), 19021011 (1), 17661912 (1) (see all 7)

    Genetic Association Database (GAD): IL23R
    Human Genome Epidemiology (HuGE) Navigator: IL23R (154 documents)

    Export disorders for IL23R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL23R gene, integrated from 10 sources (see all 254):
    (articles sorted by number of sources associating them with IL23R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PubMed id 17587057)1, 2, 4, 9 Capon F.... Nestle F.O. (Hum. Genet. 2007)
    2. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PubMed id 17068223)1, 2, 4, 9 Duerr R.H.... Cho J.H. (Science 2006)
    3. Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis. (PubMed id 18800148)1, 2, 4 Huffmeier U.... Reis A. (J. Invest. Dermatol. 2009)
    4. Genome-wide association study for Crohn's disease in the Quebec founder population identifies multiple validated disease loci. (PubMed id 17804789)1, 2, 4 Raelson J.V.... Schreiber S. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R. (PubMed id 12023369)1, 2, 3 Parham C.... Moore K.W. (J. Immunol. 2002)
    6. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. (PubMed id 19175939)1, 4, 9 Einarsdottir E....Saavalainen P. (BMC Med. Genet. 2009)
    7. ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. (PubMed id 18047540)1, 4, 9 Weersma R.K....Dijkstra G. (Am. J. Gastroenterol. 2008)
    8. Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. (PubMed id 20485703)1, 4, 9 Cotterill L....Newman W.G. (Can. J. Gastroenterol. 2010)
    9. Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus. (PubMed id 17661912)1, 4, 9 SA!nchez E....MartA-n J. (Tissue Antigens 2007)
    10. Variants of the IL23R gene are associated with ankylosing spondylitis but not with SjAPgren syndrome in Hungarian population samples. (PubMed id 19522770)1, 4, 9 SA!frA!ny E....Melegh B. (Scand. J. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 149233 HGNC: 19100 AceView: IL23R Ensembl:ENSG00000162594 euGenes: HUgn149233
    ECgene: IL23R Kegg: 149233 H-InvDB: IL23R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL23R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL23R gene:
    Search GeneIP for patents involving IL23R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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