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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL23R Gene

protein-coding   GIFtS: 62
GCID: GC01P067632

Interleukin 23 Receptor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 23 Receptor1 2
IL-23 Receptor2 3
Interleukin-23 Receptor2
IL-23R3
IBD175

External Ids:    HGNC: 191001   Entrez Gene: 1492332   Ensembl: ENSG000001625947   OMIM: 6075625   UniProtKB: Q5VWK53   

Export aliases for IL23R gene to outside databases

Previous GC identifers: GC01P066563 GC01P066989 GC01P067002 GC01P067344 GC01P065740


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL23R Gene:
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor
molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively
with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
(provided by RefSeq, Jul 2008)

GeneCards Summary for IL23R Gene: 
IL23R (interleukin 23 receptor) is a protein-coding gene. Diseases associated with IL23R include inflammatory bowel disease 17, protection against, and psoriasis, protection against, and among its related super-pathways are STAT3 Pathway and Immune response IL-23 signaling pathway. GO annotations related to this gene include interleukin-23 receptor activity and interleukin-12 receptor binding.

UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells
and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling
cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in
peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for
tumorigenesis

Gene Wiki entry for IL23R (Interleukin-23 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL23R gene promoter:
         Bach1   AP-1   GATA-1   MEF-2A   PPAR-alpha   IRF-2   Nkx6-1   aMEF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL23R promoter sequence
   Search SABiosciences Chromatin IP Primers for IL23R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL23R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

IL23R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL23R gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P067632:  view genomic region     (about GC identifiers)

Start:
67,632,083 bp from pter      End:
67,725,662 bp from pter
Size:
93,580 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5 (See protein sequence)
Recommended Name: Interleukin-23 receptor precursor  
Size: 629 amino acids; 71722 Da
Subunit: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with
JAK2 and in presence of IL23 with STAT3
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAH16829.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH70408.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI22679.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JGX4 Q4VGP1 Q4VGP2 Q4VGP3 Q4VGP4 Q4VGP5 Q4VGP6 Q5VWK7 Q8IW84 Q8NFQ9
Q96AS1
Alternative splicing: 7 isoforms:  Q5VWK5-1   Q5VWK5-2   Q5VWK5-3   Q5VWK5-4   Q5VWK5-5   Q5VWK5-6   Q5VWK5-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL23R: NX_Q5VWK5

Explore proteomics data for IL23R at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in response to IL23
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VWK5

  • IL23R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL23R Protein Expression
    REFSEQ proteins: NP_653302.2  
    ENSEMBL proteins: 
     ENSP00000321345   ENSP00000387640   ENSP00000360041   ENSP00000378652  

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    Sino Biological Cell Lysate for IL23R 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0072536interleukin-23 receptor complex IDA12023369

    IL23R for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 23 receptor 
    IL-12 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q5VWK5

    ProtoNet protein and cluster: Q5VWK5

    UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
    Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily
    Similarity: Contains 2 fibronectin type-III domains


    IL23R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL23R_HUMAN, Q5VWK5
    Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells
    and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling
    cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in
    peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for
    tumorigenesis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005143contributes to interleukin-12 receptor binding IPI12023369
    GO:0005515protein binding ----
    GO:0042019contributes to interleukin-23 binding IPI12023369
    GO:0042020contributes to interleukin-23 receptor activity IDA12023369
         
    IL23R for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il23r):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 
     tumorigenesis 

    IL23R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL23R: Il23rtm1.1Kuch Il23rtm1.2Trin Il23rtm1Dnax

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL23R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL23R

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL23R About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Development PDGF signaling via STATs and NF-kB
    Immune response IL-23 signaling pathway0.91
    IL23-mediated signaling events0.38
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF (Mouse model)0.72
    5Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IL23R
        Immune response IL-23 signaling pathway

    2 R&D Systems Pathways for IL23R
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL23R (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    3 GeneGo (Thomson Reuters) Pathways for IL23R
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Immune response IL-23 signaling pathway

    1 BioSystems Pathway for IL23R
        IL23-mediated signaling events



    3         Kegg Pathways  (Kegg details for IL23R):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Inflammatory bowel disease (IBD)


    IL23R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL23R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for IL23R (Q5VWK53 ENSP000003213454) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL12BP294603, ENSP000002312284I2D: score=1 STRING: ENSP00000231228
    IL12RB1P427013, ENSP000003144254I2D: score=3 STRING: ENSP00000314425
    IL23AQ9NPF73, ENSP000002285344I2D: score=3 STRING: ENSP00000228534
    JAK2O606743, ENSP000003710674I2D: score=1 STRING: ENSP00000371067
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity ISS--
    GO:0002230positive regulation of defense response to virus by host ISS--
    GO:0002827positive regulation of T-helper 1 type immune response ISS--
    GO:0006954inflammatory response IEA--
    GO:0010535positive regulation of activation of JAK2 kinase activity IC12023369

    IL23R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL23R

    Search CenterWatch for drugs/clinical trials and news about IL23R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL23R gene: 
    NM_144701.2  

    Unigene Cluster for IL23R:

    Interleukin 23 receptor
    Hs.677426  [show with all ESTs]
    Unigene Representative Sequence: NM_144701
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347310(uc010opo.1 uc010opq.1 uc010opr.1 uc009waz.3 uc001ddo.3 uc010opi.2 uc010opj.2 uc010opk.2 uc010opl.2 uc010opm.2 uc001ddq.3 uc010opn.2 uc001ddr.3 uc010ops.2 uc010opt.2 uc010opu.2 uc010opv.2 uc010opw.2 uc010opx.2 uc010opy.2 uc010opz.2 uc010oqa.2 uc010oqb.2 uc010oqc.2 uc010oqd.2 uc010oqe.2 uc010oqg.2 uc010oqh.2 uc010oqf.2)
    ENST00000425614 ENST00000473881 ENST00000371002(uc001ddp.2 uc010opp.1)
    ENST00000395227(uc001dds.3 uc001ddt.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF461422.1 AM990313.1 AM990314.1 AM990315.1 AM990316.1 AM990317.1 AM990318.1 AM990319.1 
    AM990320.1 AM990321.1 AM990322.1 AM990323.1 AM990324.1 AM990325.1 AM990326.1 AM990327.1 
    AM990328.1 AM990329.1 AM990330.1 AM990331.1 AM990332.1 AM990333.1 AM990334.1 AM990335.1 
    AM990336.1 AM990337.1 AY937250.1 AY937251.1 AY937252.1 AY937253.1 AY937254.1 AY937255.1 
    BC016829.1 BC040720.2 BC142955.1 FM212237.1 FM212238.1 FM212239.1 FM212240.1 FM212241.1 

    5 DOTS entries:

    DT.100017018  DT.91753478  DT.121340013  DT.121340015  DT.97823335 

    18 AceView cDNA sequences:

    NM_144701 AF461422 BC040720 BQ228535 BC016829 BU172309 BF183992 BF238439 
    BF210400 BF211696 BE622106 BF238869 BE279086 CD708943 BU570522 BF209716 
    BF185326 BF212748 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IL23R (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                  -     -                                                   
    SP2:                                                  -     -                 -                                 
    SP3:                                                  -     -                 -           -                     
    SP4:                                      -           -     -                                                   
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for IL23R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL23R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTTTAT
    IL23R Expression
    About this image


    See IL23R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL23R

    SOURCE GeneReport for Unigene cluster: Hs.677426

    UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
    Tissue specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed
    in NK cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL23R: 
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              Insulin Resistance in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL23R gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il23r1 , 5 interleukin 23 receptor1, 5 78.28(n)1
    69.5(a)1
      6 (30.85 cM)5
    2095901  NM_144548.11  NP_653131.21 
     674229325 
    chicken
    (Gallus gallus)
    Aves IL23R6
    Uncharacterized protein
    34(a)
    1 ↔ 1
    8(27530031-27540509)
    lizard
    (Anolis carolinensis)
    Reptilia IL23R6
    Uncharacterized protein
    32(a)
    1 ↔ 1
    GL343410.1(12724-51452)
    zebrafish
    (Danio rerio)
    Actinopterygii il23r6
    interleukin 23 receptor
    16(a)
    1 ↔ 1
    6(34929736-34956755)


    ENSEMBL Gene Tree for IL23R (if available)
    TreeFam Gene Tree for IL23R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL23R gene
    1 SIMAP similar gene for IL23R using alignment to 25 protein entries:     IL23R_HUMAN (see all proteins):
    IL6ST

    IL23R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2862 SNPs in IL23R are shown (see all 2862)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112090261,2,4
    C,F,Hother167778667(+) ATTCCG/AAACTG 2 /Q /R mis124Minor allele frequency- A:0.04NA EU NS EA CSA 7981
    rs584808551,2
    C--65753625(-) TTTTT-/A/TAAAGG 1 -- int10--------
    rs774218761,2
    C--65754079(-) CAAAT-/G/TGTAAA 1 -- int10--------
    rs3710027361,2
    C--65764502(+) AAACC-/AAAAAA 1 -- int10--------
    rs30529571,2
    C--65803022(+) TTTTT-/T/TT/T
    TT
    /TTTTT
    GACAG
    2 -- int1 cds10--------
    rs1386515991,2
    --65803674(+) TTTCT-/CTCTC 
            
    TTTCT
    1 -- int10--------
    rs2015855661,2
    C--65803676(+) TCTCTC/TTCTTT 1 -- int10--------
    rs672444981,2
    C--65809541(+) GTGTG-/TG    
       
    /TGTG
    AGATT
    1 -- int11NA 2
    rs340471511,2
    C--65827037(+) AAAAA-/A/AA  
            
    GGAAA
    1 -- int11NA 2
    rs57748621,2
    C--65830000(+) tatatAT/-tCTCA 1 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for IL23R (67632083 - 67725662 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IL23R:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1243CNV Loss18451855
    nsv482980CNV Loss15286789
    nsv461751CNV Loss19166990
    nsv461762CNV Gain19166990


    Human Gene Mutation Database (HGMD): IL23R
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL23R
    DNA2.0 Custom Variant and Variant Library Synthesis for IL23R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607562   
    OMIM disorders: 612261  177900  
    UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
  • Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the
    gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis
    phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most
    frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may
    contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the
    inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not
    observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Psoriasis 7 (PSORS7) [MIM:605606]: A common, chronic inflammatory disease of the skin with multifactorial
    etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions
    are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and
    epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 20/51 diseases for IL23R (see all 51):    About MalaCards
    inflammatory bowel disease 17, protection against    psoriasis, protection against    enthesitis-related arthritis    idiopathic achalasia
    juvenile psoriatic arthritis    crohn's disease    ankylosing spondylitis    chronic mucocutaneous candidiasis
    achalasia    inflammatory bowel disease    psoriatic arthritis    relapsing-remitting multiple sclerosis
    psoriasis    lyme disease    sclerosing cholangitis    osteonecrosis
    primary sclerosing cholangitis    cholangitis    spondylitis    cblc

    3 diseases from the University of Copenhagen DISEASES database for IL23R:
    Crohn's disease     Psoriasis     Ankylosing spondylitis

    IL23R for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for IL23R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory bowel diseases 74.4 18 18698678 (1), 17068223 (1), 17618837 (1), 18164077 (1) (see all 13)
    psoriasis 72.8 33 18650833 (4), 19175939 (4), 19035472 (2), 18383363 (2) (see all 12)
    colitis ulcerative 55.5 5 17068223 (1), 19175939 (1), 20192940 (1)
    rheumatoid arthritis 48.4 9 17606463 (2), 17678723 (2), 19021011 (1), 19034457 (1) (see all 6)
    autoimmune diseases 39.8 9 19522770 (2), 17606463 (1), 19021011 (1), 17661912 (1) (see all 7)

    Genetic Association Database (GAD): IL23R
    Human Genome Epidemiology (HuGE) Navigator: IL23R (154 documents)

    Export disorders for IL23R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL23R gene, integrated from 9 sources (see all 240):
    (articles sorted by number of sources associating them with IL23R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PubMed id 17587057)1, 2, 4, 9 Capon F.... Nestle F.O. (2007)
    2. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PubMed id 17068223)1, 2, 4, 9 Duerr R.H.... Cho J.H. (2006)
    3. Genetic Variants of the IL-23R Pathway: Association with Psoriatic Arthritis and Psoriasis Vulgaris, but No Specific Risk Factor for Arthritis. (PubMed id 18800148)1, 2, 4 Huffmeier U....Reis A. (2008)
    4. Genome-wide association study for Crohn's disease in the Quebec founder population identifies multiple validated disease loci. (PubMed id 17804789)1, 2, 4 Raelson J.V.... Schreiber S. (2007)
    5. A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R. (PubMed id 12023369)1, 2, 3 Parham C.... Moore K.W. (2002)
    6. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. (PubMed id 19175939)1, 4, 9 Einarsdottir E....Saavalainen P. (2009)
    7. ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. (PubMed id 18047540)1, 4, 9 Weersma R.K....Dijkstra G. (2008)
    8. Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. (PubMed id 20485703)1, 4, 9 Cotterill L....Newman W.G. (2010)
    9. Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus. (PubMed id 17661912)1, 4, 9 Sanchez E....Martin J. (2007)
    10. Variants of the IL23R gene are associated with ankylo sing spondylitis but not with SjAPgren syndrome in Hungarian population samples. (PubMed id 19522770)1, 4, 9 SA!frA!ny E....Melegh B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149233 HGNC: 19100 AceView: IL23R Ensembl:ENSG00000162594 euGenes: HUgn149233
    ECgene: IL23R Kegg: 149233 H-InvDB: IL23R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL23R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL23R gene:
    Search GeneIP for patents involving IL23R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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