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Aliases for IL23R Gene

Aliases for IL23R Gene

  • Interleukin 23 Receptor 2 3 5
  • IL-23 Receptor 4
  • IL-23R 4

External Ids for IL23R Gene

Previous GeneCards Identifiers for IL23R Gene

  • GC01P066563
  • GC01P066989
  • GC01P067002
  • GC01P067344
  • GC01P067632
  • GC01P065740

Summaries for IL23R Gene

Entrez Gene Summary for IL23R Gene

  • The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL23R Gene

IL23R (Interleukin 23 Receptor) is a Protein Coding gene. Diseases associated with IL23R include Inflammatory Bowel Disease 17, Protection Against and Psoriasis, Protection Against. Among its related pathways are Immune response IL-23 signaling pathway and Innate Immune System. GO annotations related to this gene include interleukin-12 receptor binding and interleukin-23 receptor activity.

UniProtKB/Swiss-Prot for IL23R Gene

  • Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Gene Wiki entry for IL23R Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL23R Gene

Genomics for IL23R Gene

Regulatory Elements for IL23R Gene

Enhancers for IL23R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G067194 1.1 FANTOM5 ENCODE 5.9 +56.3 56258 1.5 HDGF PKNOX1 ATF1 TBL1XR1 BMI1 YY1 TCF12 EGR1 RELB IKZF2 C1orf141 IL23R SLC35D1 WDR78 IL12RB2 MIER1 INSL5 RNU6-586P GC01M067171
GH01G067226 0.6 FANTOM5 1.8 +88.2 88216 0.4 PRDM6 POLR2A KLF17 RNU4ATAC4P RNU6-586P IL23R WDR78 C1orf141
GH01G067337 0.5 FANTOM5 1.4 +197.7 197737 0.1 HDGF IKZF1 DPF2 CREM RNU4ATAC4P SERBP1 IL12RB2 MIER1 SLC35D1 IL23R LOC105378779
GH01G067149 1.1 Ensembl ENCODE 0.4 +10.7 10668 0.6 PKNOX1 TBL1XR1 BMI1 RAD21 CHAMP1 FOS IKZF2 EGR2 ZNF654 CEBPB IL23R GC01P067166
GH01G067137 0.6 ENCODE 0.7 -0.2 -153 2.9 GATA3 HNF1A RAD51 L3MBTL2 HLF USF2 HNF4A EZH2 SPI1 C1orf141 ENSG00000252433 RNU6-586P SLC35D1 IL23R ENSG00000275678
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL23R on UCSC Golden Path with GeneCards custom track

Genomic Location for IL23R Gene

Chromosome:
1
Start:
67,138,640 bp from pter
End:
67,259,979 bp from pter
Size:
121,340 bases
Orientation:
Plus strand

Genomic View for IL23R Gene

Genes around IL23R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL23R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL23R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL23R Gene

Proteins for IL23R Gene

  • Protein details for IL23R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWK5-IL23R_HUMAN
    Recommended name:
    Interleukin-23 receptor
    Protein Accession:
    Q5VWK5
    Secondary Accessions:
    • C9JGX4
    • Q4VGP1
    • Q4VGP2
    • Q4VGP3
    • Q4VGP4
    • Q4VGP5
    • Q4VGP6
    • Q5VWK7
    • Q8IW84
    • Q8NFQ9
    • Q96AS1

    Protein attributes for IL23R Gene

    Size:
    629 amino acids
    Molecular mass:
    71722 Da
    Quaternary structure:
    • Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.
    SequenceCaution:
    • Sequence=AAH16829.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH70408.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI22679.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL23R Gene

neXtProt entry for IL23R Gene

Post-translational modifications for IL23R Gene

  • Phosphorylated in response to IL23.
  • Glycosylation at posLast=2929, isoforms=3, 447, isoforms=3, 481, posLast=141141, isoforms=3180, isoforms=3232, isoforms=2, 3262, and isoforms=2, 3, 6273
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IL23R

No data available for DME Specific Peptides for IL23R Gene

Domains & Families for IL23R Gene

Gene Families for IL23R Gene

Protein Domains for IL23R Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VWK5

UniProtKB/Swiss-Prot:

IL23R_HUMAN :
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with IL23R: view

Function for IL23R Gene

Molecular function for IL23R Gene

UniProtKB/Swiss-Prot Function:
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Gene Ontology (GO) - Molecular Function for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005143 contributes_to interleukin-12 receptor binding IPI 12023369
GO:0005515 protein binding IPI 12023369
GO:0042019 contributes_to interleukin-23 binding IPI 12023369
GO:0042020 contributes_to interleukin-23 receptor activity IDA 12023369
genes like me logo Genes that share ontologies with IL23R: view
genes like me logo Genes that share phenotypes with IL23R: view

Human Phenotype Ontology for IL23R Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL23R Gene

MGI Knock Outs for IL23R:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL23R Gene

Localization for IL23R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL23R Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL23R gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
GO:0072536 interleukin-23 receptor complex IDA 12023369
genes like me logo Genes that share ontologies with IL23R: view

Pathways & Interactions for IL23R Gene

genes like me logo Genes that share pathways with IL23R: view

SIGNOR curated interactions for IL23R Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS --
GO:0002230 positive regulation of defense response to virus by host ISS --
GO:0002376 immune system process IEA --
GO:0002827 positive regulation of T-helper 1 type immune response ISS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with IL23R: view

Drugs & Compounds for IL23R Gene

(2) Drugs for IL23R Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor Selective cyclooxygenase-2 (COX-2) inhibitor 444
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with IL23R: view

Transcripts for IL23R Gene

Unigene Clusters for IL23R Gene

Interleukin 23 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL23R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7: - -

Relevant External Links for IL23R Gene

GeneLoc Exon Structure for
IL23R
ECgene alternative splicing isoforms for
IL23R

Expression for IL23R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL23R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL23R Gene

This gene is overexpressed in Testis (x6.6) and Adrenal Gland (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL23R Gene



Protein tissue co-expression partners for IL23R Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL23R Gene:

IL23R

SOURCE GeneReport for Unigene cluster for IL23R Gene:

Hs.677426

mRNA Expression by UniProt/SwissProt for IL23R Gene:

Q5VWK5-IL23R_HUMAN
Tissue specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

Evidence on tissue expression from TISSUES for IL23R Gene

  • Blood(4.5)
  • Skin(4.3)
  • Bone marrow(4)
  • Intestine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL23R Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • face
  • head
  • meninges
  • mouth
  • neck
Thorax:
  • esophagus
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • penis
  • testicle
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with IL23R: view

Primer Products

No data available for Protein differential expression in normal tissues for IL23R Gene

Orthologs for IL23R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL23R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL23R 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia IL23R 34 35
  • 89.01 (n)
cow
(Bos Taurus)
Mammalia IL23R 34 35
  • 87 (n)
mouse
(Mus musculus)
Mammalia Il23r 34 16 35
  • 78.28 (n)
rat
(Rattus norvegicus)
Mammalia Il23r 34
  • 76.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia IL23R 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL23R 34 35
  • 48.61 (n)
lizard
(Anolis carolinensis)
Reptilia IL23R 35
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il23r 35
  • 10 (a)
OneToOne
Species where no ortholog for IL23R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL23R Gene

ENSEMBL:
Gene Tree for IL23R (if available)
TreeFam:
Gene Tree for IL23R (if available)

Paralogs for IL23R Gene

No data available for Paralogs for IL23R Gene

Variants for IL23R Gene

Sequence variations from dbSNP and Humsavar for IL23R Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11209026 other 67,240,275(+) ATTCC(A/G)AACTG intron-variant, reference, missense
rs10000172 -- 67,179,569(+) cacca(A/G)ctcct intron-variant
rs1000020635 -- 67,250,025(+) TCCAC(A/C)ATGTA intron-variant
rs1000030177 -- 67,214,489(+) TCCAT(A/T)TGCCA intron-variant
rs1000103901 -- 67,173,968(+) CTTTT(A/C)ATTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL23R Gene

Variant ID Type Subtype PubMed ID
nsv1113131 CNV deletion 24896259
nsv1243 CNV deletion 18451855
nsv461751 CNV loss 19166990
nsv461762 CNV gain 19166990
nsv546445 CNV loss 21841781
nsv546446 CNV gain 21841781

Variation tolerance for IL23R Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL23R Gene

Human Gene Mutation Database (HGMD)
IL23R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL23R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL23R Gene

Disorders for IL23R Gene

MalaCards: The human disease database

(15) MalaCards diseases for IL23R Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 17, protection against
  • inflammatory bowel disease 17
psoriasis, protection against
  • psoriasis
inflammatory bowel disease
  • inflammatory bowel diseases
idiopathic achalasia
  • achalasia
ulcerative colitis
  • left-sided ulcerative colitis
- elite association - COSMIC cancer census association via MalaCards
Search IL23R in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL23R_HUMAN
  • Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17068223, ECO:0000269 PubMed:17804789}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for IL23R

Genetic Association Database (GAD)
IL23R
Human Genome Epidemiology (HuGE) Navigator
IL23R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL23R
genes like me logo Genes that share disorders with IL23R: view

No data available for Genatlas for IL23R Gene

Publications for IL23R Gene

  1. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PMID: 17587057) Capon F. … Nestle F.O. (Hum. Genet. 2007) 3 4 22 46 64
  2. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr R.H. … Cho J.H. (Science 2006) 3 4 22 46 64
  3. Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients. (PMID: 19757086) Safrany E. … Melegh B. (Inflamm. Res. 2010) 3 22 46 64
  4. The association between interleukin-23 receptor gene polymorphisms and systemic lupus erythematosus. (PMID: 19895338) Li Y. … Zhang L. (DNA Cell Biol. 2010) 3 22 46 64
  5. Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients. (PMID: 20066736) CsAPngei V. … Melegh B. (World J. Gastroenterol. 2010) 3 22 46 64

Products for IL23R Gene

Sources for IL23R Gene

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