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Aliases for IL23R Gene

Aliases for IL23R Gene

  • Interleukin 23 Receptor 2 3
  • IL-23 Receptor 4
  • IL-23R 4
  • IBD17 6

External Ids for IL23R Gene

Summaries for IL23R Gene

Entrez Gene Summary for IL23R Gene

  • The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL23R Gene

IL23R (Interleukin 23 Receptor) is a Protein Coding gene. Diseases associated with IL23R include psoriasis, protection against and inflammatory bowel disease 17, protection against. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include interleukin-12 receptor binding and interleukin-23 receptor activity.

UniProtKB/Swiss-Prot for IL23R Gene

  • Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Gene Wiki entry for IL23R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL23R Gene

Genomics for IL23R Gene

Genomic Location for IL23R Gene

Start:
67,138,907 bp from pter
End:
67,259,979 bp from pter
Size:
121,073 bases
Orientation:
Plus strand

Genomic View for IL23R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL23R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL23R Gene

Regulatory Elements for IL23R Gene

Proteins for IL23R Gene

  • Protein details for IL23R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWK5-IL23R_HUMAN
    Recommended name:
    Interleukin-23 receptor
    Protein Accession:
    Q5VWK5
    Secondary Accessions:
    • C9JGX4
    • Q4VGP1
    • Q4VGP2
    • Q4VGP3
    • Q4VGP4
    • Q4VGP5
    • Q4VGP6
    • Q5VWK7
    • Q8IW84
    • Q8NFQ9
    • Q96AS1

    Protein attributes for IL23R Gene

    Size:
    629 amino acids
    Molecular mass:
    71722 Da
    Quaternary structure:
    • Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.
    SequenceCaution:
    • Sequence=AAH16829.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH70408.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI22679.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL23R Gene

neXtProt entry for IL23R Gene

Proteomics data for IL23R Gene at MOPED

Post-translational modifications for IL23R Gene

  • Phosphorylated in response to IL23.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn29, Asn47, Asn81, Asn141, Asn180, Asn232, Asn262, and Asn273

Other Protein References for IL23R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL23R Gene

Domains for IL23R Gene

Gene Families for IL23R Gene

Protein Domains for IL23R Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

IL23R_HUMAN
Domain:
  • Contains 2 fibronectin type-III domains.:
    • Q5VWK5
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.:
    • Q5VWK5
genes like me logo Genes that share domains with IL23R: view

Function for IL23R Gene

Molecular function for IL23R Gene

UniProtKB/Swiss-Prot Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Gene Ontology (GO) - Molecular Function for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005143 contributes_to interleukin-12 receptor binding IPI 12023369
GO:0005515 protein binding IPI 25416956
GO:0042019 contributes_to interleukin-23 binding IPI 12023369
GO:0042020 contributes_to interleukin-23 receptor activity IDA 12023369
genes like me logo Genes that share ontologies with IL23R: view
genes like me logo Genes that share phenotypes with IL23R: view

Animal Models for IL23R Gene

MGI Knock Outs for IL23R:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL23R Gene

Localization for IL23R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL23R Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL23R Gene COMPARTMENTS Subcellular localization image for IL23R gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043235 receptor complex IDA 23382219
GO:0072536 interleukin-23 receptor complex IDA 12023369
genes like me logo Genes that share ontologies with IL23R: view

Pathways for IL23R Gene

genes like me logo Genes that share pathways with IL23R: view

Gene Ontology (GO) - Biological Process for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS --
GO:0002230 positive regulation of defense response to virus by host ISS --
GO:0002827 positive regulation of T-helper 1 type immune response ISS --
GO:0006954 inflammatory response IEA --
GO:0010535 positive regulation of activation of JAK2 kinase activity IC 12023369
genes like me logo Genes that share ontologies with IL23R: view

Transcripts for IL23R Gene

Unigene Clusters for IL23R Gene

Interleukin 23 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL23R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7: - -

Relevant External Links for IL23R Gene

GeneLoc Exon Structure for
IL23R
ECgene alternative splicing isoforms for
IL23R

Expression for IL23R Gene

mRNA expression in normal human tissues for IL23R Gene

mRNA differential expression in normal tissues according to GTEx for IL23R Gene

This gene is overexpressed in Testis (6.6) and Adrenal Gland (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL23R Gene

SOURCE GeneReport for Unigene cluster for IL23R Gene Hs.677426

mRNA Expression by UniProt/SwissProt for IL23R Gene

Q5VWK5-IL23R_HUMAN
Tissue specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
genes like me logo Genes that share expressions with IL23R: view

Orthologs for IL23R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL23R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL23R 36
  • 99.26 (n)
  • 98.89 (a)
IL23R 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL23R 36
  • 87 (n)
  • 81.53 (a)
IL23R 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL23R 36
  • 89.01 (n)
  • 84.87 (a)
IL23R 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il23r 36
  • 78.28 (n)
  • 69.5 (a)
Il23r 16
Il23r 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL23R 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 27 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Il23r 36
  • 76.02 (n)
  • 63.37 (a)
chicken
(Gallus gallus)
Aves IL23R 36
  • 48.61 (n)
  • 36.59 (a)
IL23R 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL23R 37
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il23r 37
  • 10 (a)
OneToOne
Species with no ortholog for IL23R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL23R Gene

ENSEMBL:
Gene Tree for IL23R (if available)
TreeFam:
Gene Tree for IL23R (if available)

Paralogs for IL23R Gene

genes like me logo Genes that share paralogs with IL23R: view

No data available for Paralogs for IL23R Gene

Variants for IL23R Gene

Sequence variations from dbSNP and Humsavar for IL23R Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs140348 -- 67,179,867(-) TAACG(-/G)AAATG intron-variant
rs255514 -- 67,179,450(-) ccgat(C/G)ccaca intron-variant
rs380364 -- 67,179,881(-) GACTA(A/C/T)TGGGT intron-variant
rs518286 -- 67,179,864(+) ccttc(A/G)ttttg intron-variant
rs525927 -- 67,180,221(-) ACTTT(A/G/T)ACACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL23R Gene

Variant ID Type Subtype PubMed ID
nsv461751 CNV Loss 19166990
nsv461762 CNV Gain 19166990
nsv1243 CNV Loss 18451855
nsv482980 CNV Loss 15286789

Relevant External Links for IL23R Gene

HapMap Linkage Disequilibrium report
IL23R
Human Gene Mutation Database (HGMD)
IL23R

Disorders for IL23R Gene

(2) OMIM Diseases for IL23R Gene (607562)

UniProtKB/Swiss-Prot

IL23R_HUMAN
  • Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17068223, ECO:0000269 PubMed:17804789}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for IL23R Gene

(5) Novoseek inferred disease relationships for IL23R Gene

Disease -log(P) Hits PubMed IDs
inflammatory bowel diseases 74.4 13
psoriasis 72.8 20
colitis ulcerative 55.5 3
rheumatoid arthritis 48.4 8
autoimmune diseases 39.8 8

Relevant External Links for IL23R

Genetic Association Database (GAD)
IL23R
Human Genome Epidemiology (HuGE) Navigator
IL23R
genes like me logo Genes that share disorders with IL23R: view

Publications for IL23R Gene

  1. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr R.H. … Cho J.H. (Science 2006) 3 4 23 49
  2. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PMID: 17587057) Capon F. … Nestle F.O. (Hum. Genet. 2007) 3 4 23 49
  3. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. (PMID: 17236132) Cargill M. … Begovich A.B. (Am. J. Hum. Genet. 2007) 3 23 49
  4. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. (PMID: 17534574) Yamazaki K. … Hata A. (J. Hum. Genet. 2007) 3 23 49
  5. Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus. (PMID: 17661912) SA!nchez E. … MartA-n J. (Tissue Antigens 2007) 3 23 49

Products for IL23R Gene

Sources for IL23R Gene

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