IL23R Gene
protein-coding GIFtS: 57
GCID: GC01P067632
|
|
interleukin 23 receptor
| |
Aliases
for IL23R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 23 Receptor1 2 | | IL-23R1 3 | | IL-23 Receptor2 3 | | Interleukin-23 Receptor2 | | IBD175 |
Export aliases for IL23R gene to outside databasesPrevious GC identifers: GC01P066563 GC01P066989 GC01P067002 GC01P067344 GC01P065740 |
Summaries
for IL23R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL23R:
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptormolecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively withJanus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells andpossibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheraltissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis
Gene Wiki entry for IL23R (Interleukin-23 receptor)
|
Genomic Views
for IL23R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL23R gene promoter:
Bach1 AP-1 GATA-1 MEF-2A PPAR-alpha IRF-2 Nkx6-1 aMEF-2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL23R
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL23R |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.2IL23R Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P067632: view genomic region
(about GC identifiers)
Start:
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67,632,083 bp from pter |
End:
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67,725,662 bp from pter |
Size:
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93,580 bases |
Orientation:
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plus strand |
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Proteins
for IL23R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5 (See
protein sequence)Recommended Name: Interleukin-23 receptor precursor Size: 629 amino acids; 71722 Da
Subunit: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2and in presence of IL23 with STAT3
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAH16829.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CAH70408.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI22679.1;Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JGX4 Q4VGP1 Q4VGP2 Q4VGP3 Q4VGP4 Q4VGP5 Q4VGP6 Q5VWK7 Q8IW84 Q8NFQ9 Q96AS1Alternative splicing: 7 isoforms: Q5VWK5-1 Q5VWK5-2 Q5VWK5-3 Q5VWK5-4 Q5VWK5-5 Q5VWK5-6 Q5VWK5-7 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IL23R: NX_Q5VWK5
Post-translational modifications:
Phosphorylated in response to IL231
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VWK5
IL23R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653302.2
ENSEMBL proteins: ENSP00000321345 ENSP00000387640 ENSP00000360041 ENSP00000378652
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0072536 | interleukin-23 receptor complex |
IDA | 12023369 |
IL23R for ontologies About GeneDecksing
IL23R Antibody Products:
Assay Products for IL23R: |
Protein
Domains /
Families
for IL23R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL23R for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VWK5ProtoNet protein and cluster: Q5VWK5 UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamilySimilarity: Contains 2 fibronectin type-III domains |
Function
for IL23R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells andpossibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheraltissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL23R (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL23R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IL23R (NM_144701) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL23R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL23R |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23R |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
IL23R for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for IL23R: Il23rtm1.2Trin Il23rtm1.1Kuch Il23rtm1Dnax
6 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Il23r):
IL23R for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL23R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Akt Signaling | | | 2 | Development_PDGF signaling via STATs and NF-kB | | | 3 | Th17 Differentiation | | | 4 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 5 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for IL23R
2  R&D Systems Pathways for IL23R
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL23R (see all 6)
3  GeneGo (Thomson Reuters) Pathways for IL23R
1  BioSystems Pathway for IL23R
2 
Kegg Pathways (Kegg details for IL23R):
IL23R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL23R
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/42 Interacting proteins for IL23R (Q5VWK53 ENSP000003213454) via UniProtKB, MINT, STRING, and/or I2D (see all 42)About this table
Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity |
ISS | -- | | GO:0002230 | positive regulation of defense response to virus by host |
ISS | -- | | GO:0002827 | positive regulation of T-helper 1 type immune response |
ISS | -- | | GO:0006954 | inflammatory response |
IEA | -- | | GO:0010535 | positive regulation of activation of JAK2 kinase activity |
IC | 12023369 |
IL23R for ontologies About GeneDecksing
|
Drugs & Compounds
for IL23R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IL23R
Search CenterWatch for drugs/clinical trials and news about IL23R
|
Transcripts
for IL23R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL23R gene: NM_144701.2 Unigene Cluster for IL23R: Interleukin 23 receptor Hs.677426 [show with all ESTs]Unigene Representative Sequence: NM_1447015 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000347310(uc010opo.1 uc010opq.1 uc010opr.1 uc009waz.3 uc001ddo.3 uc010opi.2 uc010opj.2 uc010opk.2 uc010opl.2 uc010opm.2 uc001ddq.3 uc010opn.2 uc001ddr.3 uc010ops.2 uc010opt.2 uc010opu.2 uc010opv.2 uc010opw.2 uc010opx.2 uc010opy.2 uc010opz.2 uc010oqa.2 uc010oqb.2 uc010oqc.2 uc010oqd.2 uc010oqe.2 uc010oqg.2 uc010oqh.2 uc010oqf.2)
ENST00000425614 ENST00000473881 ENST00000371002(uc001ddp.2 uc010opp.1)
ENST00000395227(uc001dds.3 uc001ddt.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL23R (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL23R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IL23R (NM_144701) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL23R | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL23R |
Additional cDNA sequence: AF461422.1 AM990313.1 AM990314.1 AM990315.1 AM990316.1 AM990317.1 AM990318.1 AM990319.1 AM990320.1 AM990321.1 AM990322.1 AM990323.1 AM990324.1 AM990325.1 AM990326.1 AM990327.1 AM990328.1 AM990329.1 AM990330.1 AM990331.1 AM990332.1 AM990333.1 AM990334.1 AM990335.1 AM990336.1 AM990337.1 AY937250.1 AY937251.1 AY937252.1 AY937253.1 AY937254.1 AY937255.1 BC016829.1 BC040720.2 BC142955.1 FM212237.1 FM212238.1 FM212239.1 FM212240.1 FM212241.1 5 DOTS entries: DT.100017018 DT.91753478 DT.121340013 DT.121340015 DT.97823335 18 AceView cDNA sequences: NM_144701 BC040720 AF461422 BC016829 BQ228535 BU172309 BF210400 BF238439 BF211696 BE622106 BF183992 BE279086 BF238869 BU570522 CD708943 BF209716 BF185326 BF212748
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IL23R (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IL23R
|
Expression
for IL23R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL23R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTTTAT
About this image
See IL23R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL23R
SOURCE GeneReport for Unigene cluster: Hs.677426
UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5Tissue specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NKcells
SABiosciences Expression via Pathway-Focused PCR Arrays including IL23R:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL23R
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL23R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL23R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL23R | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23R |
Orthologs
for IL23R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL23R gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for IL23R (if available)
TreeFam Gene Tree for IL23R (if available) |
Paralogs
for IL23R gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL23R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL23R (67632083 - 67725662 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL23R
1 CNV: 0009
Human Gene Mutation Database (HGMD): IL23R
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL23R |
|
Disorders
/ Diseases
for IL23R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL23R for disorders About GeneDecksing
OMIM gene information: 607562
OMIM disorders: 612261 177900
UniProtKB/Swiss-Prot: IL23R_HUMAN, Q5VWK5
Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided intoCrohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract fromthe mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmuraland discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, inulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas andgranulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasisis a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scalyplaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferationand infiltration of inflammatory cells into the dermis and epidermis
20/45  diseases for IL23R (see all 45): About MalaCardsinflammatory bowel disease 17, protection against psoriasis, protection against relapsing-remitting multiple sclerosis inflammatory bowel disease
graft versus host disease sclerosing cholangitis primary sclerosing cholangitis primary biliary cirrhosis
pediatric crohns disease barrett's esophagus ankylosing spondylitis cholangitis
rheumatoid arthritis systemic lupus erythematosus aplastic anemia lupus erythematosus
psoriatic arthritis dilated cardiomyopathy multiple sclerosis achalasia
5 Novoseek disease relationships for IL23R gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammatory bowel diseases |
74.4 |
18 |
18698678 (1), 17068223 (1), 17618837 (1), 18164077 (1) (see all 13) |
| psoriasis |
72.8 |
33 |
18650833 (4), 19175939 (4), 19035472 (2), 18383363 (2) (see all 12) |
| colitis ulcerative |
55.5 |
5 |
17068223 (1), 19175939 (1), 20192940 (1) |
| rheumatoid arthritis |
48.4 |
9 |
17606463 (2), 17678723 (2), 19021011 (1), 19034457 (1) (see all 6) |
| autoimmune diseases |
39.8 |
9 |
19522770 (2), 17606463 (1), 19021011 (1), 17661912 (1) (see all 7) |
Human Genome Epidemiology (HuGE) Navigator: IL23R (154 documents)
Export disorders for IL23R gene to outside databases
|
Publications
for IL23R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL23R gene, integrated from 9 sources (see all 218):
(articles sorted by number of sources associating them with IL23R) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R. (PubMed id 12023369)1, 2, 3 Parham C.... Moore K.W. (2002)
- Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. (PubMed id 16372191)1, 2, 9 Zhang X.-Y.... Liu L. (2006)
- Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PubMed id 17587057)1, 2, 9 Capon F.... Nestle F.O. (2007)
- A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PubMed id 17068223)1, 2, 9 Duerr R.H.... Cho J.H. (2006)
- Genetic Variants of the IL-23R Pathway: Association with Psoriatic Arthritis and Psoriasis Vulgaris, but No Specific Risk Factor for Arthritis. (PubMed id 18800148)1, 2 Huffmeier U....Reis A. (2008)
- Genome-wide association study for Crohn's disease in the Quebec founder population identifies multiple validated disease loci. (PubMed id 17804789)1, 2 Raelson J.V.... Schreiber S. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. (PubMed id 19175939)1, 9 Einarsdottir E....Saavalainen P. (2009)
- ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. (PubMed id 18047540)1, 9 Weersma R.K....Dijkstra G. (2008)
|
External Searches for IL23R gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL23R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL23R gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL23R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL23R | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IL23R gene:
Search GeneIP for patents involving IL23R
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IL23R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL23R | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL23R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL23R | | | OriGene Protein Over-expression Lysate for IL23R | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL23R | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL23R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL23R | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL23R | | OriGene Custom Protein Services for IL23R | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL23R | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL23R | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL23R | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL23R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL23R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL23R |
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| | | | Search Tocris compounds for IL23R |
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 | | | IL23R Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23R |
|  |  |  | | | | ThermoFisher Antibody for IL23R |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL23R |
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