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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL23A Gene

protein-coding GIFtS: 55
GCID: GC12P056732

interleukin 23, alpha subunit p19

Explore 63 diseases affiliated with
IL23A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 23, Alpha Subunit P19¹ ²		IL-23-A² ³
SGRF¹ ² ³ ⁵		IL-23p19² ³
IL23P19¹ ² ⁵		IL-23 Subunit Alpha² ³
P19¹ ² ⁵		Interleukin 23 P19 Subunit²
IL-23¹ ²		Interleukin-23 Subunit Alpha²
IL-23A¹ ²		Interleukin-Six, G-CSF Related Factor²
Interleukin-23 Subunit P19² ³		JKA3 Induced Upon T-Cell Activation²

External Ids:	HGNC: 15488¹	Entrez Gene: 51561²	Ensembl: ENSG00000110944⁷	OMIM: 605580⁵	UniProtKB: Q9NPF7³

Export aliases for IL23A gene to outside databases

Previous GC identifers: GC12M056592 GC12P056443 GC12P055019 GC12P055020 GC12P055021 GC12P053771

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL23A:

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and

the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and

an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the

production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23

preferentially acts on memory CD4(+) T cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7

Function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and

adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds

to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade,

stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces

autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for

tumorigenesis

Gene Wiki entry for IL23A (Interleukin 23)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL23A gene promoter:
SRF RORalpha1 STAT1 STAT3 CUTL1 STAT5A Nkx2-5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL23A promoter sequence

Search SABiosciences Chromatin IP Primers for IL23A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL23A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.13

IL23A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL23A gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P056732: view genomic region (about GC identifiers)

Start:	56,732,663 bp from pter	End:	56,734,194 bp from pter
Size:	1,532 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7 (See protein sequence)

Recommended Name: Interleukin-23 subunit alpha precursor

Size: 189 amino acids; 20730 Da

Subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23

Subcellular location: Secreted. Note=Secreted upon association with IL12B

Developmental stage: Expressed by newborns dendritic cells

4 PDB 3D structures from and Proteopedia for IL23A:

3D87 (3D)

3DUH (3D)

3QWR (3D)

Secondary accessions: Q6NZ80 Q6NZ82 Q9H2A5

Explore the universe of human proteins at neXtProt for IL23A: NX_Q9NPF7

IL23A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057668.1

ENSEMBL proteins:

ENSP00000228534

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL23A (IL-23)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IL23A OriGene Protein Over-expression Lysate: IL23A OriGene Custom Protein Services for IL23A
	GenScript Custom Purified and Recombinant Proteins Services for IL23A
	Novus Biologicals IL23A Proteins Novus Biologicals IL23A Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL23A
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0070743	interleukin-23 complex	IDA	11114383

IL23A for ontologies About GeneDecksing

IL23A Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL23A
	R&D Systems Antibodies for IL23A (IL-23)
	OriGene Antibodies (see all 2): IL23A OriGene Custom Antibody Services for IL23A
	GenScript Custom Superior Antibodies Services for IL23A
	Novus Biologicals IL23A Antibodies
	Search for Antibodies for IL23A at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for IL23A

Assay Products for IL23A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL23A (IL-23) (see all)
	GenScript Custom Assay Services for IL23A
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL23A for domains About GeneDecksing

4 InterPro domains/families:

IPR009079 4_helix_cytokine-like_core

IPR012351 4_helix_cytokine_core

IPR003573 IL6_MGF_GCSF

IPR010831 IL23A

Graphical View of Domain Structure for InterPro Entry Q9NPF7

ProtoNet protein and cluster: Q9NPF7

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7

Similarity: Belongs to the IL-6 superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7

Function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and

adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds

to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade,

stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces

autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for

tumorigenesis

Induction: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or

injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL23A
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate IL23A:
		hsa-miR-623 hsa-miR-3679-5p hsa-miR-204 hsa-miR-1185 hsa-miR-211
		SwitchGear 3'UTR luciferase reporter plasmid: IL23A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL23A (see all 7) OriGene shRNA RFP: IL23A OriGene siRNA: IL23A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL23A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL23A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL23A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL23A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL23A (NM_016584)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL23A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL23A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL23A
		Search LifeMap BioReagents cell lines for IL23A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005515	protein binding	--	--
GO:0045519	contributes to interleukin-23 receptor binding	IDA	11114383

IL23A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for IL23A: Il23a^tm1.1Thak Il23a^tm1Dnax Il23a^tm1Lex
     9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Il23a):

cellular	digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	no phenotypic analysis	normal	tumorigenesis

IL23A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

1

PEDF Induced Signaling

	8/12 pathways (see all 12)
	PEDF Induced Signaling	1.00			STAT3 Pathway	0.47
	MIF Mediated Glucocorticoid Regulation	0.73			Endothelin-1 Signaling Pathway	0.44
	MIF Regulation of Innate Immune Cells	0.71			NFAT Signaling and Lymphocyte Interactions	0.37
	IL-6 Pathway	0.61			PGC1Alpha Pathway	0.33

2

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			Regulation of eIF4 and p70S6K	0.43
	MAPK Family Pathway	0.60			SOCS Pathway	0.29
	JAK-STAT Pathway	0.57

3

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

4

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

5

Development_PDGF signaling via STATs and NF-kB

	Immune response_IL-23 signaling pathway	0.44			IL23-mediated signaling events	0.15
	Immune response IL-23 signaling pathway	0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IL23A

Immune response IL-23 signaling pathway

2 R&D Systems Pathways for IL23A

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th17 Differentiation

5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL23A (see all 24)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	Tec Kinases Signaling

3 GeneGo (Thomson Reuters) Pathways for IL23A

	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF
	Immune response IL-23 signaling pathway

2 BioSystems Pathways for IL23A

	IL23-mediated signaling events
	ATF-2 transcription factor network

5 Kegg Pathways (Kegg details for IL23A):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Pertussis
	Tuberculosis
	Rheumatoid arthritis

IL23A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL23A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/33 Interacting proteins for IL23A (Q9NPF7³ ENSP00000228534⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL23R	Q5VWK5³, ENSP00000321345⁴	I2D: score=3 STRING: ENSP00000321345
IL12RB1	P42701³, ENSP00000314425⁴	I2D: score=2 STRING: ENSP00000314425
IL12B	P29460³, ENSP00000231228⁴	I2D: score=5 STRING: ENSP00000231228
IL12A	P29459³	I2D: score=1
IRF5	Q13568³	I2D: score=1

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001916	positive regulation of T cell mediated cytotoxicity	ISS	--
GO:0002230	positive regulation of defense response to virus by host	ISS	--
GO:0002827	positive regulation of T-helper 1 type immune response	TAS	16751425
GO:0006954	inflammatory response	IEA	--
GO:0009615	response to virus	--	--

IL23A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL23A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL23A
6 Novoseek chemical compound relationships for IL23A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pge2	14.7	4	19273625 (2), 15486065 (1), 17548652 (1)
wortmannin	12.9	1	16116186 (1)
oxygen	1.7	1	17464197 (1)
nitric oxide	0	3	20003607 (1), 17464197 (1)
lipid	0	2	17548652 (1)
phosphatidylinositol	0	1	16819968 (1)

Search CenterWatch for drugs/clinical trials and news about IL23A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL23A gene:

Unigene Clusters for IL23A:

Interleukin 23, alpha subunit p19

Hs.98309 [show with all ESTs], Hs.382212 [show with all ESTs]

Unigene Representative Sequences: AY359083, AK128384

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000228534(uc001sla.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL23A
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate IL23A:
		hsa-miR-623 hsa-miR-3679-5p hsa-miR-204 hsa-miR-1185 hsa-miR-211
		SwitchGear 3'UTR luciferase reporter plasmid: IL23A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL23A (see all 7) OriGene shRNA RFP: IL23A OriGene siRNA: IL23A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL23A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL23A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL23A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL23A (NM_016584)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL23A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL23A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL23A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL23A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL23A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL23A

Additional cDNA sequence:

AB011251.1 AB076757.1 AB076788.1 AB076789.1 AB076791.1 AB305802.1 AB305803.1 AB305805.1

AB305809.1 AB305810.1 AB305812.1 AB305813.1 AB305814.1 AB305816.1 AB305817.1 AB305819.1

AB305821.1 AB305822.1 AB305823.1 AB305824.1 AB305827.1 AB305832.1 AB305836.1 AB305837.1

AB305840.1 AB305848.1 AB305851.1 AB305855.1 AB305856.1 AB305858.1 AB305861.1 AB305862.1

AB305863.1 AB305865.1 AB305866.1 AB305867.1 AB305868.1 AB305869.1 AB305871.1 AB305872.1

AB305873.1 AB305874.1 AB305875.1 AB305876.1 AB305877.1 AB305878.1 AB305879.1 AB305880.1

AB305883.1 AB305885.1 AB305886.1 AB305888.1 AB305889.1 AB305891.1 AB305893.1 AB305896.1

AB305897.1 AB305900.1 AB305903.1 AB305904.1 AB305905.1 AB305907.1 AB305909.1 AB305915.1

AB305916.1 AB305925.1 AB305929.1 AB305931.1 AB305933.1 AB305943.1 AB305944.1 AB305945.1

AB305946.1 AB305950.1 AB305951.1 AB305960.1 AB305962.1 AB305965.1 AB305967.1 AB305968.1

AB305978.1 AB305979.1 AB305989.1 AB305993.1 AB305995.1 AB305996.1 AB305999.1 AB306130.1

AB306136.1 AB306138.1 AB306145.1 AB306146.1 AB306150.1 AB306157.1 AB306160.1 AB306162.1

AB306163.1 AB306165.1 AB306167.1 AB306186.1 AB306187.1 AB306198.1 AB306202.1 AB306209.1

AB306211.1 AB306221.1 AB306223.1 AB306225.1 AB306235.1 AB306239.1 AB306242.1 AB306246.1

AB306247.1 AB306249.1 AB306256.1 AB306260.1 AB306263.1 AB360840.1 AB360846.1 AB524448.1

AF009787.1 AF009789.1 AF009790.1 AF009793.1 AF037565.1 AF037566.1 AF037567.1 AF043179.1

AF043181.1 AF043182.1 AF043183.1 AF043184.1 AF045804.1 AF045805.1 AF045808.1 AF045809.1

AF045810.1 AF045811.1 AF064083.1 AF071468.1 AF071471.1 AF087019.1 AF088328.1 AF088329.1

AF088335.1 AF088338.1 AF088339.1 AF088342.1 AF088343.1 AF088368.1 AF088386.1 AF088402.1

AF088412.1 AF088430.1 AF088472.1 AF088484.1 AF088485.1 AF088487.1 AF088488.1 AF088489.1

AF088492.1 AF088493.1 AF088494.1 AF088497.1 AF088499.1 AF088501.1 AF088502.1 AF088503.1

AF088504.1 AF088505.1 AF088506.1 AF088508.1 AF088510.1 AF088511.1 AF088514.1 AF088515.1

AF088517.1 AF088518.1 AF088520.1 AF088536.1 AF088550.1 AF088597.1 AF088599.1 AF088602.1

AF088603.1 AF088612.1 AF088615.1 AF088616.1 AF088620.1 AF088625.1 AF088626.1 AF088645.1

AF088647.1 AF088651.1 AF088655.1 AF088663.1 AF088668.1 AF088670.1 AF088675.1 AF088678.1

AF088690.1 AF088691.1 AF088726.1 AF088730.1 AF088780.1 AF088798.1 AF100783.1 AF200427.1

AF200429.1 AF200430.1 AF272741.1 AF272745.1 AF317600.1 AF317602.1 AF317611.1 AF317613.1

AF321238.1 AF326332.1 AF326333.1 AF327021.1 AF327293.1 AF327294.1 AF327908.1 AF327911.1

AF327912.1 AF327913.1 AF328971.1 AF328973.1 AF328975.1 AF328976.1 AF328977.1 AF328978.1

AF387741.1 AF387751.1 AF387752.1 AF387754.1 AF387761.1 AF428131.1 AF430667.1 AF430680.1

AF430682.1 AJ007775.1 AJ007777.1 AJ007779.1 AJ276198.1 AJ276199.1 AJ276201.1 AJ305359.1

AJ305361.1 AJ305364.1 AJ305365.1 AJ305367.1 AJ305369.1 AJ437349.1 AJ437350.1 AJ437351.1

AJ437352.1 AJ437353.1 AJ437354.1 AJ437355.1 AJ437356.1 AJ437357.1 AJ437358.1 AJ437359.1

AJ437623.1 AJ437625.1 AJ437626.1 AJ437627.1 AJ437628.1 AJ437629.1 AJ437630.1 AJ437631.1

AJ437632.1 AJ437633.1 AJ437634.1 AJ437664.1 AJ437665.1 AJ437666.1 AJ437668.1 AJ506993.1

AJ507142.1 AJ507143.1 AJ507144.1 AJ507145.1 AJ507146.1 AJ507147.1 AJ507148.1 AJ568019.1

AJ568020.1 AJ568021.1 AK097858.1 AK128384.1 AK303075.1 AK303101.1 AK303112.1 AY006137.1

AY006140.1 AY006149.1 AY006201.1 AY006310.1 AY123167.1 AY123168.1 AY123169.1 AY123170.1

AY123192.1 AY124782.1 AY190114.1 AY236338.1 AY239354.1 AY239355.1 AY247833.1 AY247837.1

AY292261.1 AY292262.1 AY292263.1 AY292265.1 AY292266.1 AY292270.1 AY292271.1 AY292274.1

AY359884.1 AY373826.1 AY424671.1 AY424672.1 AY424673.1 AY424674.1 AY424675.1 AY424676.1

AY424677.1 AY424678.1 AY424679.1 AY424680.1 AY424681.1 AY424682.1 AY424683.1 AY424684.1

AY424685.1 AY424686.1 AY424687.1 AY424688.1 AY424689.1 AY424690.1 AY424691.1 AY475217.1

AY475218.1 AY513883.1 AY517621.1 AY517622.1 AY532914.1 AY534315.1 AY751837.1 AY751861.1

AY751866.1 AY751867.1 AY751899.1 AY751903.1 AY751907.1 AY751918.1 AY751928.1 AY751929.1

AY758390.1 AY834220.1 BC028083.1 BC030533.1 BC036926.1 BC070387.1 BC108321.1 BC110303.1

D21846.1 D21848.1 D50744.1 D50772.1 DQ081719.1 DQ081720.1 DQ294631.1 DQ341454.1

DQ341455.1 DQ341456.1 DQ341457.1 DQ341459.1 DQ341460.1 DQ341461.1 DQ341462.1 DQ341463.1

DQ341464.1 DQ358121.1 DQ358122.1 EF567066.1 EF567067.1 EF567073.1 EF567074.1 EF591993.1

EF591995.1 EF592001.1 EF592002.1 EF592008.1 EF592009.1 EF592013.1 EF592014.1 EF592017.1

EF592018.1 EF592020.1 EF592021.1 EF592022.1 EF592026.1 EF592027.1 EF592030.1 EU030678.1

EU325966.1 EU325967.1 EU325968.1 EU325970.1 EU325971.1 EU325972.1 EU325973.1 EU325974.1

EU325975.1 EU325976.1 EU325977.1 EU325978.1 EU325979.1 EU325980.1 EU340841.1 EU368854.1

EU379940.1 EU427375.1 EU427377.1 EU599572.1 EU647219.1 EU885172.1 EU885174.1 EU885188.1

FJ571144.1 FJ795358.1 FJ795360.1 FJ795362.1 FJ795364.1 FJ795366.1 GQ179995.1 GU122927.1

GU997642.1 GU997643.1 GU997645.1 GU997646.1 GU997647.1 GU997648.1 HM467868.1 HM467869.1

HM467886.1 HM467899.1 HM777516.1 JF731133.1 JF731134.1 JF731135.1 JF731138.1 JF731139.1

JF731142.1 JF731143.1 JF731144.1 JF731145.1 JF731146.1 JF731147.1 JF731148.1 JF731149.1

JF731150.1 JF731151.1 JF731152.1 JF731153.1 JF731154.1 JF731155.1 JF731156.1 JF731159.1

JF731160.1 JF731161.1 JF731162.1 JF731163.1 JF731164.1 JF731165.1 JF731170.1 JF731172.1

JF731173.1 JF731174.1 JF731175.1 JF731176.1 JF731182.1 JF731183.1 JF731185.1 JF731186.1

JF731187.1 JF731188.1 JF731190.1 JF731191.1 JF731192.1 JF731193.1 JF731194.1 JF731196.1

JF731197.1 JF731198.1 JF731199.1 JF731200.1 JF731201.1 JF731202.1 JF731203.1 JF731204.1

JF731205.1 JF731207.1 JF731208.1 JF731210.1 JF731211.1 JF731212.1 JF731216.1 JF731217.1

JF731218.1 JF731219.1 JF731221.1 JF731223.1 JF731225.1 JF731227.1 JF731228.1 JF731229.1

JF731232.1 JN019786.1 K02779.1 L10119.1 L14854.1 L26452.1 L26454.1 L26456.1

L26458.1 L29037.1 L29038.1 L34724.1 L34725.1 L34734.1 L34740.1 M12883.1

M12886.1 M13553.1 M13843.1 M13844.1 M13845.1 M13846.1 M13847.1 M13860.1

M13865.1 M14264.1 M14266.1 M14267.1 M14269.1 M15221.1 M18461.1 M18462.1

M27382.1 M73463.1 M90476.1 M97711.1 M97713.1 M97723.1 S48146.1 S63248.1

S69310.1 U40991.1 U41097.1 U46029.1 U51443.1 U51445.1 U51447.1 U79183.1

U80779.1 U85051.1 U85053.1 U85054.1 U87866.1 X01410.1 X01411.1 X02515.1

X04921.1 X04928.1 X04929.1 X51790.1 X51793.1 X51796.1 X56665.1 X57610.1

X58330.1 X60096.1 X63456.1 X74845.1 X74846.1 X86117.1 X86136.1 Z22967.1

Z23040.1 Z23041.1 Z29580.1 Z29582.1 Z47369.1 Z47372.1 Z47374.1 Z77831.1

Z77836.1 Z77838.1

24/153 DOTS entries (see all 153):

DT.92456573 DT.108033 DT.95360200 DT.92456560 DT.95166474 DT.102841081 DT.95151074 DT.95108808

DT.91978113 DT.95166428 DT.102841078 DT.95177124 DT.100740595 DT.100032309 DT.91817977 DT.99998685

DT.100778969 DT.121076149 DT.75151320 DT.92014537 DT.92456542 DT.121076958 DT.95135143 DT.100016065

24/54 AceView cDNA sequences (see all 54):

BM127426 AI796983 AY359083 NM_016584 CA310002 AJ277049 CK906317 CD559625

BC067513 CD370253 AB030000 AA418747 BI828409 BC067512 BM126874 CA314674

BC067511 AW072323 AF301620 CA306280 CD559628 BI520230 CA748831 CA306849

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL23A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATACTTCTC

About this image

IL23A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Protocol derived cells

Posterior foregut-like cells (A scalable, suspensi...)

Positive expression

Microarrays (high-throughput)

Expression:

Positive

Negative

cell-identifying gene

Selective marker

Experimental details:

Curated

High-throughput

Microarrays

In-situ hybridization

See IL23A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL23A

SOURCE GeneReport for Unigene clusters: Hs.98309 Hs.382212

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7

Tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal

Langerhans cells (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including IL23A (see all 8):

Innate & Adaptive Immune Responses in human mouse rat

Th17 Response in human mouse rat

Cytokines & Chemokines in human mouse rat

Common Cytokines in human mouse rat

T Helper Cell Differentiation in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL23A Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL23A gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il23a^{1 , 5}	interleukin 23, alpha subunit p19^{1, 5}	82.09(n)¹ 75(a)¹		10 (76.51 cM)⁵ 83430¹ NM_031252.2¹ NP_112542.1¹ 128296140⁵

ENSEMBL Gene Tree for IL23A (if available)
TreeFam Gene Tree for IL23A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

--

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73131077^1,2	C,	--	56730687(+)	`CTCCTG/ACAGCA`	1	--	us2k¹		1		NA	120
rs189869219^1,2		--	56730927(+)	`ACCTTA/TTTAGG`	1	--	us2k¹		0	--	--	--	--
rs149661053^1,2		--	56731012(+)	`TTTCC-/ATTTTT`	1	--	us2k¹		0	--	--	--	--
rs11835054^1,2	C,F,H,	--	56731055(+)	`gtcacG/Ccaggc`	1	--	us2k¹		1		NA	4
rs111492967^1,2	C,	--	56731077(+)	`GGCGCG/CATCTC`	1	--	us2k¹		2		WA CSA	3
rs112188779^1,2		--	56731291(+)	`CAGGCA/GTGAGC`	1	--	us2k¹		1		CSA	1
rs181446540^1,2		--	56731410(+)	`CAGTTA/TTGAAT`	1	--	us2k¹		0	--	--	--	--
rs185400182^1,2		--	56731663(+)	`GAAATC/TGGTGT`	1	--	us2k¹		0	--	--	--	--
rs11465742^1,2	C,F,H,	--	56731664(+)	`AAATCG/AGTGTC`	1	--	us2k¹		9		NA EU NS EA	796
rs79813541^1,2		--	56731697(+)	`AACAAA/GCTGAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL23A (56732663 - 56734194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL23A
1 CNV: 0164

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL23A

DNA2.0 Custom Variant and Variant Library Synthesis for IL23A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL23A for disorders           About GeneDecksing

OMIM gene information: 605580    OMIM disorders: --

20/63 diseases for IL23A (see all 63):    About MalaCards

relapsing-remitting multiple sclerosis hypersensitivity reaction type ii disease graft versus host disease chronic mucocutaneous candidiasis

inflammatory bowel disease mycosis fungoides connective tissue disease spontaneous abortion

chronic obstructive pulmonary disease lupus erythematosus bronchiolitis obliterans ankylosing spondylitis

klebsiella rheumatoid arthritis multiple sclerosis systemic lupus erythematosus

allergic rhinitis aplastic anemia gastroenteritis duodenal ulcer

1 disease from the University of Copenhagen DISEASES database for IL23A:

10/24 Novoseek disease relationships for IL23A gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis	75.5	40	15560760 (4), 19264456 (4), 17706835 (3), 17074928 (3) (see all 24)
autoimmune diseases	70.1	17	19570828 (2), 18587636 (1), 20071030 (1), 17564777 (1) (see all 12)
multiple sclerosis	58	13	16751425 (2), 17727629 (1), 20218921 (1), 17237441 (1) (see all 8)
encephalomyelitis	57.4	4	17727629 (1), 20071030 (1), 16290228 (1), 17237441 (1)
inflammation	50.2	35	16482511 (3), 16670770 (3), 16374252 (2), 16290228 (2) (see all 20)
immunopathology	49.1	1	16482511 (1)
inflammatory bowel diseases	49	9	17548652 (3), 20228197 (2), 17487329 (1), 17476421 (1) (see all 5)
autoimmunity	48.9	5	19161421 (1), 16290228 (1), 16043992 (1)
colitis ulcerative	46	2	16374252 (2)
necrosis	43.8	30	18512248 (1), 19661527 (1), 19811465 (1), 17476678 (1) (see all 22)

Human Genome Epidemiology (HuGE) Navigator: IL23A (8 documents)

Export disorders for IL23A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL23A gene, integrated from 9 sources (see all 347):
(articles sorted by number of sources associating them with IL23A)

Utopia: connect your pdf to the dynamic
world of online information

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. (PubMed id 11114383)^{1, 2, 3, 9} Oppmann B....Kastelein R.A. (2000)
IL-23 is increased in dendritic cells in multiple sclerosis and down- regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. (PubMed id 16751425)^{1, 2, 9} Vaknin-Dembinsky A.... Weiner H.L. (2006)
Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. (PubMed id 12421946)^{1, 2, 9} Pirhonen J.... Julkunen I. (2002)
The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. (PubMed id 18680750)^{1, 2, 9} Lupardus P.J. and Garcia K.C. (2008)
A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R. (PubMed id 12023369)^{1, 2, 9} Parham C.... Moore K.W. (2002)
Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. (PubMed id 16342235)^{1, 2, 9} Vanden Eijnden S.... Willems F. (2006)
Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway. (PubMed id 15486065)^{1, 2, 9} Schnurr M.... Maraskovsky E. (2005)
Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. (PubMed id 15114670)^{1, 2, 9} Smits H.H.... Kapsenberg M.L. (2004)
IL-23 promotes tumour incidence and growth. (PubMed id 16688182)^{1, 2} Langowski J.L.... Oft M. (2006)
In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. (PubMed id 16424222)^{1, 2} Piskin G.... Teunissen M.B.M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

			AND	OR
	Aliases
	Disorders
	Free Text

	Query String		PubMed OMIM NCBI Bookshelf
		(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51561	HGNC: 15488	AceView: IL23A	Ensembl:ENSG00000110944	euGenes: HUgn51561
ECgene: IL23A	Kegg: 51561	H-InvDB: IL23A

(According to HUGE)
About This Section

--

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL23A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IL23A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IL23A gene:
Search GeneIP for patents involving IL23A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

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