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Aliases for IL23A Gene

Aliases for IL23A Gene

  • Interleukin 23 Subunit Alpha 2 3 5
  • Interleukin-Six, G-CSF Related Factor 2 3
  • Interleukin 23, Alpha Subunit P19 2 3
  • Interleukin-23 Subunit P19 3 4
  • IL-23 Subunit Alpha 3 4
  • IL-23p19 3 4
  • IL-23-A 3 4
  • SGRF 3 4
  • JKA3 Induced Upon T-Cell Activation 3
  • Interleukin-23 Subunit Alpha 3
  • Interleukin 23 P19 Subunit 3
  • IL23P19 3
  • IL-23A 3
  • IL-23 3
  • P19 3

External Ids for IL23A Gene

Previous GeneCards Identifiers for IL23A Gene

  • GC12M056592
  • GC12P056443
  • GC12P055019
  • GC12P055020
  • GC12P055021
  • GC12P056732
  • GC12P053771

Summaries for IL23A Gene

Entrez Gene Summary for IL23A Gene

  • This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL23A Gene

IL23A (Interleukin 23 Subunit Alpha) is a Protein Coding gene. Diseases associated with IL23A include Psoriasis and Rheumatoid Arthritis. Among its related pathways are IL27-mediated signaling events and Immune System. GO annotations related to this gene include cytokine activity and interleukin-23 receptor binding.

UniProtKB/Swiss-Prot for IL23A Gene

  • Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene Wiki entry for IL23A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL23A Gene

Genomics for IL23A Gene

Regulatory Elements for IL23A Gene

Enhancers for IL23A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F056358 1.1 FANTOM5 ENCODE 21.9 +25.7 25727 3.3 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 STAT2 ENSG00000257303 IL23A RNU6-343P CDK2 RBMS2 NEMP1 LOC100131294 BAZ2A RPL41
GH12F056336 1.3 FANTOM5 Ensembl ENCODE 21.6 +3.8 3831 4.6 HDGF PKNOX1 ATF1 ARNT CREB3L1 ZNF121 ELK1 GTF2B JUNB NCOA1 ENSG00000257303 IL23A NEMP1 BAZ2A STAT2 RN7SL809P MMP19 PAN2 ZC3H10 GC12P056341
GH12F056298 0.6 ENCODE 11 -33.3 -33348 4.6 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 BAZ2A CDK2 RN7SL809P ZC3H10 NEMP1 ENSG00000257303 TMEM198B ANKRD52 SMARCC2 RPL41
GH12F056296 0.9 Ensembl 10.9 -37.3 -37258 0.6 HLF CEBPB CEBPG ELF1 TSHZ1 ZEB2 SCRT2 CEBPA ADNP KLF7 ENSG00000257303 COQ10A ANKRD52 SLC39A5 NABP2 RNF41 IL23A PAN2 APOF GC12P056293
GH12F056297 0.2 Ensembl 10.9 -38.0 -37958 0.4 BCOR ZNF384 SCRT2 ADNP ZNF584 ZNF362 L3MBTL2 E2F5 ZEB2 ELF1 COQ10A ANKRD52 SLC39A5 NABP2 RNF41 IL23A PAN2 APOF MYL6B ENSG00000257303
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IL23A on UCSC Golden Path with GeneCards custom track

Genomic Location for IL23A Gene

Chromosome:
12
Start:
56,334,158 bp from pter
End:
56,340,410 bp from pter
Size:
6,253 bases
Orientation:
Plus strand

Genomic View for IL23A Gene

Genes around IL23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL23A Gene

Proteins for IL23A Gene

  • Protein details for IL23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPF7-IL23A_HUMAN
    Recommended name:
    Interleukin-23 subunit alpha
    Protein Accession:
    Q9NPF7
    Secondary Accessions:
    • Q6NZ80
    • Q6NZ82
    • Q9H2A5

    Protein attributes for IL23A Gene

    Size:
    189 amino acids
    Molecular mass:
    20730 Da
    Quaternary structure:
    • Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

    Three dimensional structures from OCA and Proteopedia for IL23A Gene

neXtProt entry for IL23A Gene

Post-translational modifications for IL23A Gene

No Post-translational modifications

Other Protein References for IL23A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for IL23A

No data available for DME Specific Peptides for IL23A Gene

Domains & Families for IL23A Gene

Gene Families for IL23A Gene

Protein Domains for IL23A Gene

Suggested Antigen Peptide Sequences for IL23A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPF7

UniProtKB/Swiss-Prot:

IL23A_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL23A: view

Function for IL23A Gene

Molecular function for IL23A Gene

UniProtKB/Swiss-Prot Function:
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.

Gene Ontology (GO) - Molecular Function for IL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 11114383
GO:0045519 contributes_to interleukin-23 receptor binding IEA,IDA 11114383
genes like me logo Genes that share ontologies with IL23A: view
genes like me logo Genes that share phenotypes with IL23A: view

Animal Models for IL23A Gene

MGI Knock Outs for IL23A:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL23A

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL23A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL23A Gene

Localization for IL23A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL23A Gene

Secreted. Note=Secreted upon association with IL12B.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL23A Gene COMPARTMENTS Subcellular localization image for IL23A gene
Compartment Confidence
extracellular 5
cytosol 2
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0070743 interleukin-23 complex IDA 11114383
genes like me logo Genes that share ontologies with IL23A: view

Pathways & Interactions for IL23A Gene

genes like me logo Genes that share pathways with IL23A: view

SIGNOR curated interactions for IL23A Gene

Activates:

Gene Ontology (GO) - Biological Process for IL23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS --
GO:0002230 positive regulation of defense response to virus by host IEA,ISS --
GO:0002376 immune system process IEA --
GO:0002827 positive regulation of T-helper 1 type immune response IEA,TAS 16751425
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with IL23A: view

Drugs & Compounds for IL23A Gene

(6) Drugs for IL23A Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ustekinumab Approved, Investigational Pharma antibody, Target 82
Briakinumab Investigational Pharma Target 0
CNTO 1275 Pharma 0

(3) Additional Compounds for IL23A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL23A: view

Transcripts for IL23A Gene

Unigene Clusters for IL23A Gene

Interleukin 23, alpha subunit p19:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL23A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL23A Gene

No ASD Table

Relevant External Links for IL23A Gene

GeneLoc Exon Structure for
IL23A
ECgene alternative splicing isoforms for
IL23A

Expression for IL23A Gene

mRNA expression in normal human tissues for IL23A Gene

mRNA differential expression in normal tissues according to GTEx for IL23A Gene

This gene is overexpressed in Testis (x10.4).

NURSA nuclear receptor signaling pathways regulating expression of IL23A Gene:

IL23A

SOURCE GeneReport for Unigene cluster for IL23A Gene:

Hs.98309

mRNA Expression by UniProt/SwissProt for IL23A Gene:

Q9NPF7-IL23A_HUMAN
Tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
genes like me logo Genes that share expression patterns with IL23A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL23A Gene

Orthologs for IL23A Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL23A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia IL23A 34 35
  • 88.36 (n)
cow
(Bos Taurus)
Mammalia IL23A 34 35
  • 86.77 (n)
rat
(Rattus norvegicus)
Mammalia Il23a 34
  • 84.57 (n)
mouse
(Mus musculus)
Mammalia Il23a 34 16 35
  • 82.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL23A 35
  • 46 (a)
OneToOne
Species where no ortholog for IL23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL23A Gene

ENSEMBL:
Gene Tree for IL23A (if available)
TreeFam:
Gene Tree for IL23A (if available)

Paralogs for IL23A Gene

No data available for Paralogs for IL23A Gene

Variants for IL23A Gene

Sequence variations from dbSNP and Humsavar for IL23A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111326153 -- 56,335,465(+) AACTC(C/T)GTCTC intron-variant, upstream-variant-2KB
rs111492967 -- 56,337,293(+) GGCGC(C/G)ATCTC intron-variant, upstream-variant-2KB
rs11171805 -- 56,337,951(+) CCTTC(C/G)ACTAC intron-variant, upstream-variant-2KB
rs11171806 -- 56,339,747(+) GGATC(A/G)GATAT reference, synonymous-codon
rs111932562 -- 56,340,850(+) TTTTT(C/T)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IL23A Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for IL23A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL23A Gene

Disorders for IL23A Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL23A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
psoriasis
rheumatoid arthritis
  • rheumatoid arthritis, progression of
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
chronic mucocutaneous candidiasis
  • cmc
- elite association - COSMIC cancer census association via MalaCards
Search IL23A in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL23A

Genetic Association Database (GAD)
IL23A
Human Genome Epidemiology (HuGE) Navigator
IL23A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL23A
genes like me logo Genes that share disorders with IL23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL23A Gene

Publications for IL23A Gene

  1. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. (PMID: 11114383) Oppmann B. … Kastelein R.A. (Immunity 2000) 2 3 4 22 64
  2. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (PMID: 19169254) Nair R.P. … Abecasis G.R. (Nat. Genet. 2009) 3 22 46 64
  3. The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. (PMID: 18680750) Lupardus P.J. … Garcia K.C. (J. Mol. Biol. 2008) 3 4 22 64
  4. Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. (PMID: 16342235) Vanden Eijnden S. … Willems F. (Eur. J. Immunol. 2006) 3 4 22 64
  5. IL-23 is increased in dendritic cells in multiple sclerosis and down- regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. (PMID: 16751425) Vaknin-Dembinsky A. … Weiner H.L. (J. Immunol. 2006) 3 4 22 64

Products for IL23A Gene

  • Cloud-Clone Corp. Antibodies for IL23A
  • Cloud-Clone Corp. Proteins for IL23A
  • Cloud-Clone Corp Assay Kits for IL23A

Sources for IL23A Gene

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