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IL23A Gene

protein-coding   GIFtS: 56
GCID: GC12P056732

Interleukin 23, Alpha Subunit P19

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 23, Alpha Subunit P191 2     G-CSF Related Factor1
SGRF2 3 5     interleukin-six1
Interleukin-23 Subunit P192 3     IL-232
IL-23-A2 3     IL-23A2
IL-23p192 3     Interleukin 23 P19 Subunit2
IL-23 Subunit Alpha2 3     Interleukin-23 Subunit Alpha2
IL23P192 5     Interleukin-Six, G-CSF Related Factor2
P192 5     JKA3 Induced Upon T-Cell Activation2

External Ids:    HGNC: 154881   Entrez Gene: 515612   Ensembl: ENSG000001109447   OMIM: 6055805   UniProtKB: Q9NPF73   

Export aliases for IL23A gene to outside databases

Previous GC identifers: GC12M056592 GC12P056443 GC12P055019 GC12P055020 GC12P055021 GC12P053771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL23A Gene:
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein
and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12
(IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4,
and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T
cells, IL23 preferentially acts on memory CD4(+) T cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL23A Gene:
IL23A (interleukin 23, alpha subunit p19) is a protein-coding gene. GO annotations related to this gene include interleukin-23 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7
Function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate
and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling
cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23
induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be
important for tumorigenesis

Gene Wiki entry for IL23A (Interleukin 23) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL23A gene promoter:
         SRF   RORalpha1   STAT1   STAT3   CUTL1   STAT5A   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL23A promoter sequence
   Search Chromatin IP Primers for IL23A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL23A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.13

IL23A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL23A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056732:  view genomic region     (about GC identifiers)

Start:
56,732,663 bp from pter      End:
56,734,194 bp from pter
Size:
1,532 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7 (See protein sequence)
Recommended Name: Interleukin-23 subunit alpha precursor  
Size: 189 amino acids; 20730 Da
Subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23
Developmental stage: Expressed by newborns dendritic cells
4 PDB 3D structures from and Proteopedia for IL23A:
3D85 (3D)        3D87 (3D)        3DUH (3D)        3QWR (3D)    
Secondary accessions: Q6NZ80 Q6NZ82 Q9H2A5

Explore the universe of human proteins at neXtProt for IL23A: NX_Q9NPF7

Explore proteomics data for IL23A at MOPED


See IL23A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057668.1  
ENSEMBL proteins: 
 ENSP00000228534  

IL23A Human Recombinant Protein Products:

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Novus Biologicals IL23A Proteins
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Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for IL23A
Browse Proteins at Cloud-Clone Corp.

 
eBioscience Proteins for IL23A: (see all 3
                    Human IL-23 Recombinant Protein 10 ug

 
antibodies-online proteins for IL23A (12 products) 

 
antibodies-online peptides for IL23A

IL23A Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of IL23A
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Novus Biologicals IL23A Antibodies
Abcam antibodies for IL23A
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antibodies-online antibodies for IL23A (85 products) 

IL23A Assay Products:

Browse Kits and Assays available from EMD Millipore
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eBioscience ELISAs for IL23A: (see all 3
                    Human IL-23 (p19/p40) Platinum ELISA 2 x 96 tests
antibodies-online kits for IL23A (53 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IL: Interleukins and interleukin receptors

4 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR010831 IL-23_alpha
 IPR009079 4_helix_cytokine-like_core
 IPR003573 IL-6/IL-23/GCSF/MGF

Graphical View of Domain Structure for InterPro Entry Q9NPF7

ProtoNet protein and cluster: Q9NPF7

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7
Similarity: Belongs to the IL-6 superfamily


Find genes that share domains with IL23A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL23A_HUMAN, Q9NPF7
Function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate
and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling
cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23
induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be
important for tumorigenesis
Induction: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger
or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in
tumors

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005515protein binding ----
GO:0045519contributes to interleukin-23 receptor binding IDA11114383
     
Find genes that share ontologies with IL23A           About GenesLikeMe


Phenotypes:
     8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Il23a):
 digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
 no phenotypic analysis  normal  tumorigenesis 

Find genes that share phenotypes with IL23A           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for IL23A: Il23atm1.1Thak Il23atm1Dnax Il23atm1Lex

   genOway: Develop your customized and physiologically relevant rodent model for IL23A

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidIL23A 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat IL23A

Gene Editing
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GenScript: all cDNA clones in your preferred vector: IL23A (NM_016584)
Sino Biological Human cDNA Clone for IL23A
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL23A

Cell Line
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In Situ Assay
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Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA1-10581) for IL23A 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IL23A_HUMAN, Q9NPF7: Secreted. Note=Secreted upon association with IL12B
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol1
lysosome1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0070743interleukin-23 complex IDA11114383

Find genes that share ontologies with IL23A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL23A About   (see all 14)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Immune response IL 23 signaling pathway
Immune response IL 23 signaling pathway0.41
IL23-mediated signaling events0.38
3TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
4Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
5ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61


Find genes that share SuperPaths with IL23A           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 R&D Systems Pathways for IL23A
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
Th17 Differentiation

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL23A (see all 24)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Tec Kinases Signaling

3 GeneGo (Thomson Reuters) Pathways for IL23A
    Cytokine production by Th17 cells in CF (Mouse model)
Cytokine production by Th17 cells in CF
Immune response IL-23 signaling pathway

2 BioSystems Pathways for IL23A
    ATF-2 transcription factor network
IL23-mediated signaling events



Selected Kegg Pathways  (Kegg details for IL23A) (see all 6):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Pertussis
Tuberculosis
Inflammatory bowel disease (IBD)

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL23A (see all 8): 
          Innate & Adaptive Immune Responses in human mouse rat
          Th17 Response in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Common Cytokines in human mouse rat
          T Helper Cell Differentiation in human mouse rat

Interactions:

    GeneGlobe Interaction Network for IL23A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for IL23A (Q9NPF73 ENSP000002285344) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
InteractantInteraction Details
GeneCardExternal ID(s)
IL23RQ5VWK53, ENSP000003213454I2D: score=3 STRING: ENSP00000321345
IL12RB1P427013, ENSP000003144254I2D: score=2 STRING: ENSP00000314425
IL12BP294603, ENSP000002312284I2D: score=5 STRING: ENSP00000231228
IL12AP294593I2D: score=1 
IRF5Q135683I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001916positive regulation of T cell mediated cytotoxicity ISS--
GO:0002230positive regulation of defense response to virus by host ISS--
GO:0002827positive regulation of T-helper 1 type immune response TAS16751425
GO:0006954inflammatory response IEA--
GO:0006955immune response ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IL23A

6 Novoseek inferred chemical compound relationships for IL23A gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pge2 14.7 4 19273625 (2), 15486065 (1), 17548652 (1)
wortmannin 12.9 1 16116186 (1)
oxygen 1.7 1 17464197 (1)
nitric oxide 0 3 20003607 (1), 17464197 (1)
lipid 0 2 17548652 (1)
phosphatidylinositol 0 1 16819968 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IL23A gene: 
NM_016584.2  

Unigene Clusters for IL23A:

Interleukin 23, alpha subunit p19
Hs.98309  [show with all ESTs], Hs.382212  [show with all ESTs]
Unigene Representative Sequences: AY359083, AK128384
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000228534(uc001sla.3)
miRNA
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hsa-miR-623 hsa-miR-3679-5p hsa-miR-204 hsa-miR-1185 hsa-miR-211
SwitchGear 3'UTR luciferase reporter plasmidIL23A 3' UTR sequence
Inhib. RNA
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL23A
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Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA1-10581) for IL23A 

Additional mRNA sequence: 

AB011251.1 AB076757.1 AB076788.1 AB076789.1 AB076791.1 AB305802.1 AB305803.1 AB305805.1 
AB305809.1 AB305810.1 AB305812.1 AB305813.1 AB305814.1 AB305816.1 AB305817.1 AB305819.1 
AB305821.1 AB305822.1 AB305823.1 AB305824.1 AB305827.1 AB305832.1 AB305836.1 AB305837.1 
AB305840.1 AB305848.1 AB305851.1 AB305855.1 AB305856.1 AB305858.1 AB305861.1 AB305862.1 
AB305863.1 AB305865.1 AB305867.1 AB305868.1 AB305869.1 AB305871.1 AB305872.1 AB305873.1 
AB305874.1 AB305875.1 AB305876.1 AB305877.1 AB305878.1 AB305879.1 AB305880.1 AB305883.1 
AB305885.1 AB305886.1 AB305888.1 AB305889.1 AB305891.1 AB305893.1 AB305896.1 AB305897.1 
AB305900.1 AB305903.1 AB305904.1 AB305905.1 AB305906.1 AB305907.1 AB305909.1 AB305910.1 
AB305916.1 AB305925.1 AB305929.1 AB305931.1 AB305933.1 AB305943.1 AB305944.1 AB305945.1 
AB305946.1 AB305950.1 AB305951.1 AB305960.1 AB305962.1 AB305965.1 AB305967.1 AB305968.1 
AB305978.1 AB305989.1 AB305993.1 AB305995.1 AB305996.1 AB305999.1 AB306130.1 AB306136.1 
AB306138.1 AB306145.1 AB306146.1 AB306150.1 AB306157.1 AB306160.1 AB306162.1 AB306163.1 
AB306167.1 AB306186.1 AB306187.1 AB306198.1 AB306202.1 AB306211.1 AB306221.1 AB306223.1 
AB306225.1 AB306235.1 AB306239.1 AB306242.1 AB306246.1 AB306247.1 AB306249.1 AB306256.1 
AB306260.1 AB306263.1 AB360840.1 AB360846.1 AB524448.1 AF009787.1 AF009789.1 AF009790.1 
AF009793.1 AF037565.1 AF037566.1 AF037567.1 AF043179.1 AF043181.1 AF043182.1 AF043183.1 
AF043184.1 AF045804.1 AF045805.1 AF045808.1 AF045809.1 AF045810.1 AF045811.1 AF064083.1 
AF071468.1 AF071471.1 AF087019.1 AF088328.1 AF088329.1 AF088335.1 AF088338.1 AF088339.1 
AF088342.1 AF088343.1 AF088368.1 AF088386.1 AF088402.1 AF088412.1 AF088430.1 AF088472.1 
AF088484.1 AF088485.1 AF088487.1 AF088488.1 AF088489.1 AF088492.1 AF088493.1 AF088494.1 
AF088497.1 AF088499.1 AF088501.1 AF088502.1 AF088503.1 AF088504.1 AF088505.1 AF088506.1 
AF088508.1 AF088510.1 AF088511.1 AF088514.1 AF088515.1 AF088517.1 AF088518.1 AF088520.1 
AF088536.1 AF088550.1 AF088597.1 AF088599.1 AF088600.1 AF088603.1 AF088612.1 AF088616.1 
AF088617.1 AF088620.1 AF088625.1 AF088626.1 AF088633.1 AF088642.1 AF088645.1 AF088647.1 
AF088651.1 AF088655.1 AF088656.1 AF088663.1 AF088668.1 AF088670.1 AF088673.1 AF088675.1 
AF088678.1 AF088690.1 AF088691.1 AF088694.1 AF088699.1 AF088740.1 AF088748.1 AF088766.1 
AF088780.1 AF088798.1 AF100783.1 AF200427.1 AF200429.1 AF200430.1 AF272741.1 AF272743.1 
AF272745.1 AF317600.1 AF317602.1 AF317606.1 AF317611.1 AF317613.1 AF321238.1 AF326332.1 
AF326333.1 AF327021.1 AF327293.1 AF327294.1 AF327908.1 AF327911.1 AF327912.1 AF327913.1 
AF328971.1 AF328973.1 AF328975.1 AF328976.1 AF328977.1 AF328978.1 AF387741.1 AF387751.1 
AF387752.1 AF387754.1 AF387761.1 AF428131.1 AF430667.1 AF430680.1 AF430682.1 AJ007775.1 
AJ007777.1 AJ007779.1 AJ276198.1 AJ276199.1 AJ276201.1 AJ296361.1 AJ305359.1 AJ305361.1 
AJ305364.1 AJ305365.1 AJ305367.1 AJ305369.1 AJ437349.1 AJ437350.1 AJ437351.1 AJ437352.1 
AJ437353.1 AJ437354.1 AJ437355.1 AJ437356.1 AJ437357.1 AJ437358.1 AJ437359.1 AJ437623.1 
AJ437625.1 AJ437626.1 AJ437627.1 AJ437628.1 AJ437629.1 AJ437630.1 AJ437631.1 AJ437632.1 
AJ437633.1 AJ437634.1 AJ437664.1 AJ437665.1 AJ437666.1 AJ437668.1 AJ506993.1 AJ507142.1 
AJ507143.1 AJ507144.1 AJ507145.1 AJ507146.1 AJ507147.1 AJ507148.1 AJ568019.1 AJ568020.1 
AJ568021.1 AK097858.1 AK128384.1 AK303075.1 AK303101.1 AK303112.1 AY006137.1 AY006140.1 
AY006149.1 AY006201.1 AY006310.1 AY123167.1 AY123168.1 AY123169.1 AY123170.1 AY123192.1 
AY124782.1 AY190114.1 AY236338.1 AY239354.1 AY239355.1 AY247833.1 AY247837.1 AY292261.1 
AY292262.1 AY292263.1 AY292265.1 AY292266.1 AY292270.1 AY292271.1 AY292274.1 AY359884.1 
AY373826.1 AY424671.1 AY424672.1 AY424673.1 AY424674.1 AY424675.1 AY424676.1 AY424677.1 
AY424678.1 AY424679.1 AY424680.1 AY424681.1 AY424682.1 AY424683.1 AY424684.1 AY424685.1 
AY424686.1 AY424687.1 AY424688.1 AY424689.1 AY424690.1 AY424691.1 AY475217.1 AY475218.1 
AY513883.1 AY517621.1 AY517622.1 AY532914.1 AY751837.1 AY751861.1 AY751866.1 AY751867.1 
AY751868.1 AY751886.1 AY751899.1 AY751903.1 AY751907.1 AY751918.1 AY751928.1 AY751929.1 
AY758390.1 AY834220.1 BC028083.1 BC030533.1 BC036926.1 BC070387.1 BC108321.1 BC110303.1 
D21846.1 D21848.1 D50744.1 D50772.1 DQ081719.1 DQ081720.1 DQ294631.1 DQ341454.1 
DQ341455.1 DQ341456.1 DQ341457.1 DQ341459.1 DQ341460.1 DQ341461.1 DQ341462.1 DQ341463.1 
DQ341464.1 DQ358121.1 DQ358122.1 EF567066.1 EF567067.1 EF567073.1 EF567074.1 EF591993.1 
EF591995.1 EF592001.1 EF592002.1 EF592008.1 EF592009.1 EF592013.1 EF592014.1 EF592017.1 
EF592020.1 EF592021.1 EF592022.1 EF592026.1 EF592027.1 EF592030.1 EU030678.1 EU325966.1 
EU325967.1 EU325968.1 EU325970.1 EU325971.1 EU325972.1 EU325973.1 EU325974.1 EU325975.1 
EU325976.1 EU325977.1 EU325978.1 EU325979.1 EU325980.1 EU340841.1 EU368854.1 EU379940.1 
EU427375.1 EU427377.1 EU599572.1 EU647219.1 EU885172.1 EU885174.1 EU885188.1 FJ571144.1 
FJ795358.1 FJ795360.1 FJ795362.1 FJ795364.1 FJ795366.1 GQ179995.1 GU122927.1 GU997642.1 
GU997643.1 GU997645.1 GU997646.1 GU997647.1 GU997648.1 HM467840.1 HM467850.1 HM467857.1 
HM467868.1 HM467869.1 HM467897.1 HM467899.1 HM777516.1 JF731133.1 JF731134.1 JF731135.1 
JF731138.1 JF731139.1 JF731142.1 JF731143.1 JF731144.1 JF731145.1 JF731146.1 JF731147.1 
JF731148.1 JF731149.1 JF731150.1 JF731151.1 JF731152.1 JF731153.1 JF731154.1 JF731155.1 
JF731156.1 JF731159.1 JF731160.1 JF731161.1 JF731162.1 JF731163.1 JF731164.1 JF731165.1 
JF731170.1 JF731172.1 JF731173.1 JF731174.1 JF731175.1 JF731176.1 JF731182.1 JF731183.1 
JF731185.1 JF731186.1 JF731187.1 JF731188.1 JF731190.1 JF731191.1 JF731192.1 JF731193.1 
JF731194.1 JF731196.1 JF731197.1 JF731198.1 JF731199.1 JF731200.1 JF731201.1 JF731202.1 
JF731203.1 JF731204.1 JF731205.1 JF731207.1 JF731208.1 JF731210.1 JF731211.1 JF731212.1 
JF731216.1 JF731217.1 JF731218.1 JF731219.1 JF731221.1 JF731225.1 JF731227.1 JF731228.1 
JF731229.1 JF731232.1 JN019786.1 K02779.1 L10119.1 L14854.1 L26452.1 L26454.1 
L26456.1 L26458.1 L29037.1 L29038.1 L34721.1 L34724.1 L34725.1 L34734.1 
L34740.1 M12883.1 M12886.1 M13553.1 M13843.1 M13844.1 M13845.1 M13846.1 
M13847.1 M13860.1 M13865.1 M14264.1 M14266.1 M14267.1 M14269.1 M15221.1 
M18461.1 M18462.1 M27382.1 M73463.1 M90476.1 M97709.1 M97711.1 M97713.1 
M97723.1 S48146.1 S63248.1 S69310.1 S75167.1 U39135.1 U40991.1 U41097.1 
U46029.1 U51443.1 U51445.1 U51447.1 U79183.1 U80779.1 U85051.1 U85053.1 
U85054.1 U87866.1 X01410.1 X01411.1 X02515.1 X04921.1 X04928.1 X04929.1 
X51790.1 X51793.1 X51796.1 X56665.1 X57610.1 X58330.1 X60096.1 X63456.1 
X74845.1 X74846.1 X86117.1 X86136.1 Z22967.1 Z23040.1 Z23041.1 Z29580.1 
Z29582.1 Z47369.1 Z47372.1 Z47374.1 Z77831.1 Z77836.1 Z77838.1 

Selected DOTS entries (see all 158):

DT.92456573  DT.108033  DT.95360200  DT.92456560  DT.95166474  DT.95166428  DT.95151074  DT.102841081 
DT.95108808  DT.91978113  DT.100032309  DT.102841078  DT.95177124  DT.100740595  DT.91817977  DT.99998685 
DT.100778969  DT.121076149  DT.121076958  DT.75151320  DT.92014537  DT.92456542  DT.95135143  DT.100016065 

Selected AceView cDNA sequences (see all 54):

BM126874 AY359083 CA314674 AB030000 BC067513 AJ277049 AA418747 CA310002 
BM127426 BC067512 BI828409 CD370253 CD559625 BC067511 CK906317 AI796983 
NM_016584 BC066267 BI520230 CA306849 AF301620 CD559628 AW072323 BC066269 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL23A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATACTTCTC
IL23A Expression
About this image

IL23A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IL23A Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.98309 Hs.382212

UniProtKB/Swiss-Prot: IL23A_HUMAN, Q9NPF7
Tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by
dermal Langerhans cells (at protein level)

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL23A (see all 8): 
          Innate & Adaptive Immune Responses in human mouse rat
          Th17 Response in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Common Cytokines in human mouse rat
          T Helper Cell Differentiation in human mouse rat

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OriGene qPCR primer pairs and template standards for IL23A
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL23A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for IL23A gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il23a1 , 5 interleukin 23, alpha subunit p191, 5 82.09(n)1
75(a)1
  10 (76.51 cM)5
834301  NM_031252.21  NP_112542.11 
 1282961405 


ENSEMBL Gene Tree for IL23A (if available)
TreeFam Gene Tree for IL23A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL23A (see all 116)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs731310771,2
C,F--56730687(+) CTCCTG/ACAGCA 1 -- us2k11Minor allele frequency- A:0.01NA 120
rs1898692191,2
--56730927(+) ACCTTA/TTTAGG 1 -- us2k10--------
rs1496610531,2
C--56731012(+) TTTCC-/ATTTTT 1 -- us2k10--------
rs118350541,2
C,F,H--56731055(+) gtcacG/Ccaggc 1 -- us2k11Minor allele frequency- C:0.50NA 4
rs1114929671,2
C--56731077(+) GGCGCG/CATCTC 1 -- us2k12Minor allele frequency- C:0.33WA CSA 3
rs1121887791,2
F--56731291(+) CAGGCA/GTGAGC 1 -- us2k11Minor allele frequency- G:0.00CSA 1
rs1814465401,2
--56731410(+) CAGTTA/TTGAAT 1 -- us2k10--------
rs1854001821,2
--56731663(+) GAAATC/TGGTGT 1 -- us2k10--------
rs114657421,2
C,F,H--56731664(+) AAATCG/AGTGTC 1 -- us2k19Minor allele frequency- A:0.00NA EU NS EA 796
rs798135411,2
F--56731697(+) AACAAA/GCTGAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IL23A (56732663 - 56734194 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IL23A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv482992CNV Complex15286789

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IL23A
DNA2.0 Custom Variant and Variant Library Synthesis for IL23A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605580    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for IL23A:
Psoriasis

Find genes that share disorders with IL23A           About GenesLikeMe

Selected Novoseek inferred disease relationships for IL23A gene (see all 24)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 75.5 40 15560760 (4), 19264456 (4), 17706835 (3), 17074928 (3) (see all 24)
autoimmune diseases 70.1 17 19570828 (2), 18587636 (1), 20071030 (1), 17564777 (1) (see all 12)
multiple sclerosis 58 13 16751425 (2), 17727629 (1), 20218921 (1), 17237441 (1) (see all 8)
encephalomyelitis 57.4 4 17727629 (1), 20071030 (1), 16290228 (1), 17237441 (1)
inflammation 50.2 35 16482511 (3), 16670770 (3), 16374252 (2), 16290228 (2) (see all 20)
immunopathology 49.1 1 16482511 (1)
inflammatory bowel diseases 49 9 17548652 (3), 20228197 (2), 17487329 (1), 17476421 (1) (see all 5)
autoimmunity 48.9 5 19161421 (1), 16290228 (1), 16043992 (1)
colitis ulcerative 46 2 16374252 (2)
necrosis 43.8 30 18512248 (1), 19661527 (1), 19811465 (1), 17476678 (1) (see all 22)

Genetic Association Database (GAD): IL23A
Human Genome Epidemiology (HuGE) Navigator: IL23A (8 documents)

Export disorders for IL23A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IL23A gene, integrated from 10 sources (see all 370):
(articles sorted by number of sources associating them with IL23A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. (PubMed id 11114383)1, 2, 3, 9 Oppmann B....Kastelein R.A. (Immunity 2000)
  2. IL-23 is increased in dendritic cells in multiple sclerosis and down- regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. (PubMed id 16751425)1, 2, 9 Vaknin-Dembinsky A.... Weiner H.L. (J. Immunol. 2006)
  3. Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. (PubMed id 12421946)1, 2, 9 Pirhonen J.... Julkunen I. (J. Immunol. 2002)
  4. The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. (PubMed id 18680750)1, 2, 9 Lupardus P.J. and Garcia K.C. (J. Mol. Biol. 2008)
  5. A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R. (PubMed id 12023369)1, 2, 9 Parham C.... Moore K.W. (J. Immunol. 2002)
  6. Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. (PubMed id 16342235)1, 2, 9 Vanden Eijnden S.... Willems F. (Eur. J. Immunol. 2006)
  7. Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway. (PubMed id 15486065)1, 2, 9 Schnurr M.... Maraskovsky E. (Blood 2005)
  8. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (PubMed id 19169254)1, 4, 9 Nair R.P....Abecasis G.R. (Nat. Genet. 2009)
  9. Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility. (PubMed id 19034457)1, 4, 9 Park J.H....Bae S.C. (Rheumatol. Int. 2009)
  10. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. (PubMed id 19262574)1, 4, 9 Elder J.T. (Genes Immun. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51561 HGNC: 15488 AceView: IL23A Ensembl:ENSG00000110944 euGenes: HUgn51561
ECgene: IL23A Kegg: 51561 H-InvDB: IL23A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL23A Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL23A Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL23A gene:
Search GeneIP for patents involving IL23A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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