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IL22RA2 Gene

protein-coding   GIFtS: 58
GCID: GC06M137464

Interleukin 22 Receptor, Alpha 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 22 Receptor, Alpha 21 2     CRF2X2
Cytokine Receptor Class-II Member 102 3     ZCYTOR162
Cytokine Receptor Family Type 2, Soluble 12 3     Interleukin 22-Binding Protein2
CRF2-102 3     Interleukin-22 Receptor Subunit Alpha-22
CRF2-S12 3     ZcytoR163
IL-22BP2 3     Cytokine Receptor Family 2 Member 103
IL-22R-alpha-22 3     IL-22 Receptor Subunit Alpha-23
IL-22RA22 3     Interleukin-22-Binding Protein3
IL22BP3 5     

External Ids:    HGNC: 149011   Entrez Gene: 1163792   Ensembl: ENSG000001644857   OMIM: 6066485   UniProtKB: Q969J53   

Export aliases for IL22RA2 gene to outside databases

Previous GC identifers: GC06M137088 GC06M137312 GC06M137445 GC06M137506 GC06M135028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL22RA2 Gene:
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically
binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface
receptor. The encoded protein may be important in the regulation of inflammatory response, and has been
implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript
variants encoding distinct isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for IL22RA2 Gene:
IL22RA2 (interleukin 22 receptor, alpha 2) is a protein-coding gene. GO annotations related to this gene include interleukin-22 receptor activity and interleukin-22 binding. An important paralog of this gene is IL20RA.

UniProtKB/Swiss-Prot: I22R2_HUMAN, Q969J5
Function: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex
and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of
inflammatory responses
Function: Isoform 1 may play a role in establishing and maintaining successful pregnancy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL22RA2 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   Meis-1a   Meis-1b   Meis-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL22RA2 promoter sequence
   Search Chromatin IP Primers for IL22RA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL22RA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.3   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q24.1-q24.2

IL22RA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL22RA2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M137464:  view genomic region     (about GC identifiers)

Start:
137,464,957 bp from pter      End:
137,494,785 bp from pter
Size:
29,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I22R2_HUMAN, Q969J5 (See protein sequence)
Recommended Name: Interleukin-22 receptor subunit alpha-2 precursor  
Size: 263 amino acids; 30550 Da
Sequence caution: Sequence=AAQ89097.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for IL22RA2:
3G9V (3D)    
Secondary accessions: Q08AH7 Q6UWM1 Q96A41 Q96QR0
Alternative splicing: 3 isoforms:  Q969J5-1   Q969J5-2   Q969J5-3   

Explore the universe of human proteins at neXtProt for IL22RA2: NX_Q969J5

Explore proteomics data for IL22RA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56

  • See IL22RA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_443194.1  NP_851826.1  NP_851827.1  

    ENSEMBL proteins: 
     ENSP00000296979   ENSP00000296980   ENSP00000340920  

    IL22RA2 Human Recombinant Protein Products:

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    Novus Biologicals IL22RA2 Lysate
    Sino Biological Recombinant Protein for IL22RA2
    Sino Biological Cell Lysate for IL22RA2
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for IL22RA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-22 receptor alpha2
    IL-10 receptor family

    3 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q969J5

    ProtoNet protein and cluster: Q969J5

    UniProtKB/Swiss-Prot: I22R2_HUMAN, Q969J5
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 3 fibronectin type-III domains


    Find genes that share domains with IL22RA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I22R2_HUMAN, Q969J5
    Function: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex
    and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of
    inflammatory responses
    Function: Isoform 1 may play a role in establishing and maintaining successful pregnancy

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042017interleukin-22 binding IDA11390453
    GO:0042018interleukin-22 receptor activity IDA11390454
         
    Find genes that share ontologies with IL22RA2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL22RA2:
     High actin ratio cells  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il22ra2):
     digestive/alimentary  homeostasis/metabolism  immune system  tumorigenesis 

    Find genes that share phenotypes with IL22RA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il22ra2tm1Lex for IL22RA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL22RA2
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    6 qRT-PCR Assays for microRNAs that regulate IL22RA2:
    hsa-miR-3163 hsa-miR-3658 hsa-miR-4263 hsa-miR-3121-3p hsa-miR-580 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmidIL22RA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL22RA2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): IL22RA2 (NM_181310)
    Sino Biological Human cDNA Clone for IL22RA2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22RA2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22RA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I22R2_HUMAN, Q969J5: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    lysosome1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS11390453
    GO:0005829cytosol IEA--

    Find genes that share ontologies with IL22RA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL22RA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Antigen presentation by MHC class II
    Immune response IL 22 signaling pathway0.31
    IL-22 Pathway0.00
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    3PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    4Jak-STAT signaling pathway
    Jak-STAT signaling pathway


    Find genes that share SuperPaths with IL22RA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL22RA2
        IL-22 Pathway
    MAPK Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for IL22RA2
        Immune response IL-22 signaling pathway



    2 Kegg Pathways  (Kegg details for IL22RA2):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL22RA2: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL22RA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for IL22RA2 (Q969J52, 3 ENSP000002969804) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL22Q9GZX62, 3, ENSP000003293844MINT-7010533 I2D: score=4 STRING: ENSP00000329384
    CBLENSP000002640334STRING: ENSP00000264033
    CBLBENSP000002641224STRING: ENSP00000264122
    CBLCENSP000002702794STRING: ENSP00000270279
    JAK1ENSP000003432044STRING: ENSP00000343204
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019221cytokine-mediated signaling pathway IDA11390454
    GO:0042516regulation of tyrosine phosphorylation of Stat3 protein ISS--
    GO:0050728negative regulation of inflammatory response IEA--

    Find genes that share ontologies with IL22RA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL22RA2 (I22R2)

    1 Novoseek inferred chemical compound relationship for IL22RA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 19.1 4 15611059 (1), 18297515 (1), 8241949 (1)



    Find genes that share compounds with IL22RA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL22RA2 gene (3 alternative transcripts): 
    NM_052962.2  NM_181309.1  NM_181310.1  

    Unigene Cluster for IL22RA2:

    Interleukin 22 receptor, alpha 2
    Hs.126891  [show with all ESTs]
    Unigene Representative Sequence: NM_052962
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349184(uc003qhm.3) ENST00000296980(uc003qhl.3) ENST00000339602(uc003qhn.3)

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate IL22RA2:
    hsa-miR-3163 hsa-miR-3658 hsa-miR-4263 hsa-miR-3121-3p hsa-miR-580 hsa-miR-1251
    SwitchGear 3'UTR luciferase reporter plasmidIL22RA2 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22RA2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL22RA2
      QuantiTect SYBR Green Assays in human, mouse, rat IL22RA2
      QuantiFast Probe-based Assays in human, mouse, rat IL22RA2

    Additional mRNA sequence: 

    AJ297262.1 AJ313161.1 AJ313162.1 AY040566.1 AY040567.1 AY040568.1 AY044429.1 AY358111.1 
    AY358737.1 BC125167.1 BC125168.1 

    3 DOTS entries:

    DT.40126692  DT.100017485  DT.95074771 

    20 AceView cDNA sequences:

    AY040568 AJ297262 AY040567 AY040566 AY044429 NM_052962 NM_181310 NM_181309 
    AY358737 AJ313162 AY358111 AI793278 AI824338 AJ313161 BE672507 BX107059 
    AV714177 BE348657 AI733254 AA932515 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL22RA2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                          -                     
    SP3:                          -           -         


    ECgene alternative splicing isoforms for IL22RA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL22RA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGACAGAA
    IL22RA2 Expression
    About this image


    IL22RA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebellum
    IL22RA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL22RA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126891

    UniProtKB/Swiss-Prot: I22R2_HUMAN, Q969J5
    Tissue specificity: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract,
    testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow,
    liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at
    lower level in spleen, skin, thymus and stomach

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL22RA2: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IL22RA2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL22RA2
    QuantiTect SYBR Green Assays in human, mouse, rat IL22RA2
    QuantiFast Probe-based Assays in human, mouse, rat IL22RA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22RA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL22RA2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il22ra21 , 5 interleukin 22 receptor, alpha 21, 5 77.97(n)1
    66.96(a)1
      10 (8.52 cM)5
    2373101  NM_178258.51  NP_839989.21 
     196219985 
    chicken
    (Gallus gallus)
    Aves IL22RA21 interleukin 22 receptor, alpha 2 59.67(n)
    49.32(a)
      770428  XM_004935703.1  XP_004935760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crfb91 cytokine receptor family member b9 49.92(n)
    37.31(a)
      692307  NM_001045279.1  NP_001038744.1 


    ENSEMBL Gene Tree for IL22RA2 (if available)
    TreeFam Gene Tree for IL22RA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL22RA2 gene
    IL20RA2  IL22RA12  

    Find genes that share paralogs with IL22RA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL22RA2 (see all 728)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167696361,2
    C,F--137464467(+) GACTTT/CGGTTT 3 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1862411431,2
    --137464741(+) GAAAGC/TGGGGA 3 -- ds50010--------
    rs283621781,2
    C,F--137464742(-) CTCCCC/TGCTTT 3 -- ds50013Minor allele frequency- T:0.02NS WA 208
    rs283621771,2
    C--137464765(-) AAAAGC/TGTTGA 3 -- ds50013Minor allele frequency- T:0.02NS WA 208
    rs1379574161,2
    --137464828(+) TCGGGA/CTCAAA 3 -- ds50010--------
    rs170661021,2
    C,F,H--137464837(+) AAACTC/GTTTGC 3 -- ds500114Minor allele frequency- N:0.01NA NS EA WA 1086
    rs2025651,2
    C,F,A,H--137464916(+) ATTGTA/GTTCTT 3 -- ds500125Minor allele frequency- G:0.06NS EA NA WA CSA 2192
    rs1494892201,2
    --137464998(+) ATATAC/TCCCTA 3 -- ut310--------
    rs2025661,2
    C,F,O,H--137465074(+) CAAAAC/ACAGAG 3 -- ut3129Minor allele frequency- A:0.08MN NA NS EA WA CSA 2253
    rs283621761,2
    C,F,H--137465084(-) GTTTGC/TCTTGC 3 -- ut3112Minor allele frequency- T:0.05NS NA CSA WA 1450

    HapMap Linkage Disequilibrium report for IL22RA2 (137464957 - 137494785 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IL22RA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470863CNV Loss18288195
    nsv886687CNV Loss21882294
    dgv2012e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606648    OMIM disorders: --


    Find genes that share disorders with IL22RA2           About GenesLikeMe

    Genetic Association Database (GAD): IL22RA2
    Human Genome Epidemiology (HuGE) Navigator: IL22RA2 (4 documents)

    Export disorders for IL22RA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL22RA2 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with IL22RA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. (PubMed id 11481447)1, 2, 3, 9 Xu W.... Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. (PubMed id 11390454)1, 2, 3, 9 Kotenko S.V.... Pestka S. (J. Immunol. 2001)
    3. Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22. (PubMed id 19285080)1, 2, 9 de Moura P.R.... Polikarpov I. (FEBS Lett. 2009)
    4. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. (PubMed id 15201862)1, 2, 9 Weiss B....Sabat R. (Genes Immun. 2004)
    5. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. (PubMed id 11390453)1, 2, 9 Dumoutier L.... Renauld J.-C. (J. Immunol. 2001)
    6. Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis. (PubMed id 19926456)1, 4 Kingo K....KA/ks S. (J. Dermatol. Sci. 2010)
    7. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    9. Cloning and characterization of mouse IL-22 binding protein. (PubMed id 12700595)1, 2 Wei C.-C.... Chang M.-S. (Genes Immun. 2003)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116379 HGNC: 14901 AceView: IL22RA2 Ensembl:ENSG00000164485 euGenes: HUgn116379
    ECgene: IL22RA2 Kegg: 116379 H-InvDB: IL22RA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL22RA2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il22ra2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL22RA2 gene:
    Search GeneIP for patents involving IL22RA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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