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Aliases for IL22RA2 Gene

Aliases for IL22RA2 Gene

  • Interleukin 22 Receptor Subunit Alpha 2 2 3 5
  • Cytokine Receptor Family Type 2, Soluble 1 3 4
  • Cytokine Receptor Class-II Member 10 3 4
  • Interleukin 22 Receptor, Alpha 2 2 3
  • IL-22R-Alpha-2 3 4
  • ZCYTOR16 3 4
  • IL-22RA2 3 4
  • CRF2-10 3 4
  • CRF2-S1 3 4
  • IL-22BP 3 4
  • Cytokine Receptor Family 2 Member 10 4
  • Interleukin 22-Binding Protein 3
  • IL-22 Receptor Subunit Alpha-2 4
  • Interleukin-22-Binding Protein 4
  • IL22BP 4
  • CRF2X 3

External Ids for IL22RA2 Gene

Previous GeneCards Identifiers for IL22RA2 Gene

  • GC06M137312
  • GC06M137445
  • GC06M137506
  • GC06M135028
  • GC06M137464

Summaries for IL22RA2 Gene

Entrez Gene Summary for IL22RA2 Gene

  • This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL22RA2 Gene

IL22RA2 (Interleukin 22 Receptor Subunit Alpha 2) is a Protein Coding gene. Among its related pathways are Jak-STAT signaling pathway and Immune System. GO annotations related to this gene include interleukin-22 binding and interleukin-22 receptor activity. An important paralog of this gene is IL22RA1.

UniProtKB/Swiss-Prot for IL22RA2 Gene

  • Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.

  • Isoform 1 may play a role in establishing and maintaining successful pregnancy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL22RA2 Gene

Genomics for IL22RA2 Gene

Regulatory Elements for IL22RA2 Gene

Enhancers for IL22RA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL22RA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL22RA2 Gene

Chromosome:
6
Start:
137,143,820 bp from pter
End:
137,173,648 bp from pter
Size:
29,829 bases
Orientation:
Minus strand

Genomic View for IL22RA2 Gene

Genes around IL22RA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL22RA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL22RA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22RA2 Gene

Proteins for IL22RA2 Gene

  • Protein details for IL22RA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969J5-I22R2_HUMAN
    Recommended name:
    Interleukin-22 receptor subunit alpha-2
    Protein Accession:
    Q969J5
    Secondary Accessions:
    • Q08AH7
    • Q6UWM1
    • Q96A41
    • Q96QR0

    Protein attributes for IL22RA2 Gene

    Size:
    263 amino acids
    Molecular mass:
    30550 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL22RA2 Gene

    Alternative splice isoforms for IL22RA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL22RA2 Gene

Proteomics data for IL22RA2 Gene at MOPED

Post-translational modifications for IL22RA2 Gene

  • Glycosylation at Asn 56
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22RA2 Gene

Antibody Products

No data available for DME Specific Peptides for IL22RA2 Gene

Domains & Families for IL22RA2 Gene

Gene Families for IL22RA2 Gene

Protein Domains for IL22RA2 Gene

Suggested Antigen Peptide Sequences for IL22RA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969J5

UniProtKB/Swiss-Prot:

I22R2_HUMAN :
  • Contains 3 fibronectin type-III domains.
  • Belongs to the type II cytokine receptor family.
Domain:
  • Contains 3 fibronectin type-III domains.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL22RA2: view

Function for IL22RA2 Gene

Molecular function for IL22RA2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
UniProtKB/Swiss-Prot Function:
Isoform 1 may play a role in establishing and maintaining successful pregnancy.
genes like me logo Genes that share phenotypes with IL22RA2: view

Animal Models for IL22RA2 Gene

MGI Knock Outs for IL22RA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL22RA2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL22RA2 Gene

Localization for IL22RA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22RA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL22RA2 Gene COMPARTMENTS Subcellular localization image for IL22RA2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL22RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IL22RA2: view

Pathways & Interactions for IL22RA2 Gene

genes like me logo Genes that share pathways with IL22RA2: view

Pathways by source for IL22RA2 Gene

1 GeneGo (Thomson Reuters) pathway for IL22RA2 Gene
2 Qiagen pathways for IL22RA2 Gene

SIGNOR curated interactions for IL22RA2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IL22RA2 Gene

None

Drugs & Compounds for IL22RA2 Gene

(1) Drugs for IL22RA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IL22RA2: view

Transcripts for IL22RA2 Gene

mRNA/cDNA for IL22RA2 Gene

Unigene Clusters for IL22RA2 Gene

Interleukin 22 receptor, alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL22RA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3: - -

Relevant External Links for IL22RA2 Gene

GeneLoc Exon Structure for
IL22RA2
ECgene alternative splicing isoforms for
IL22RA2

Expression for IL22RA2 Gene

mRNA expression in normal human tissues for IL22RA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL22RA2 Gene

This gene is overexpressed in Spleen (x9.2), Breast - Mammary Tissue (x9.2), Skin - Not Sun Exposed (Suprapubic) (x6.2), Small Intestine - Terminal Ileum (x5.4), and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for IL22RA2 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL22RA2 Gene



SOURCE GeneReport for Unigene cluster for IL22RA2 Gene Hs.126891

mRNA Expression by UniProt/SwissProt for IL22RA2 Gene

Q969J5-I22R2_HUMAN
Tissue specificity: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.
genes like me logo Genes that share expression patterns with IL22RA2: view

Protein tissue co-expression partners for IL22RA2 Gene

Primer Products

Orthologs for IL22RA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22RA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL22RA2 35
  • 80 (n)
  • 71.2 (a)
IL22RA2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL22RA2 35
  • 87.3 (n)
  • 82.68 (a)
IL22RA2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il22ra2 35
  • 77.97 (n)
  • 66.96 (a)
Il22ra2 16
Il22ra2 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL22RA2 35
  • 98.61 (n)
  • 98.48 (a)
IL22RA2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il22ra2 35
  • 78.89 (n)
  • 72.49 (a)
oppossum
(Monodelphis domestica)
Mammalia IL22RA2 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL22RA2 36
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL22RA2 35
  • 59.67 (n)
  • 49.32 (a)
IL22RA2 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crfb9 35
  • 49.92 (n)
  • 37.31 (a)
crfb9 36
  • 32 (a)
OneToOne
Species with no ortholog for IL22RA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL22RA2 Gene

ENSEMBL:
Gene Tree for IL22RA2 (if available)
TreeFam:
Gene Tree for IL22RA2 (if available)

Paralogs for IL22RA2 Gene

Paralogs for IL22RA2 Gene

genes like me logo Genes that share paralogs with IL22RA2: view

Variants for IL22RA2 Gene

Sequence variations from dbSNP and Humsavar for IL22RA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs28385692 - 137,161,703(-) CTTCC(C/T)TACTG reference, missense
rs28362173 - 137,147,796(-) AAAAG(A/G)AAAAA intron-variant, reference, missense
rs1040622 -- 137,162,121(+) ACTAG(C/T)GGGGC intron-variant
rs5880333 -- 137,146,995(+) GTCTC(-/A)CAAAA intron-variant
rs6570136 -- 137,173,485(+) GGGAC(A/G)CCATG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IL22RA2 Gene

Variant ID Type Subtype PubMed ID
nsv470863 CNV Loss 18288195
nsv886687 CNV Loss 21882294
dgv2012e1 CNV Complex 17122850

Variation tolerance for IL22RA2 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL22RA2 Gene

Disorders for IL22RA2 Gene

Relevant External Links for IL22RA2

Genetic Association Database (GAD)
IL22RA2
Human Genome Epidemiology (HuGE) Navigator
IL22RA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL22RA2

No disorders were found for IL22RA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL22RA2 Gene

Publications for IL22RA2 Gene

  1. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. (PMID: 11481447) Xu W. … Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23 67
  2. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. (PMID: 11390454) Kotenko S.V. … Pestka S. (J. Immunol. 2001) 2 3 23
  3. Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22. (PMID: 19285080) de Moura P.R. … Polikarpov I. (FEBS Lett. 2009) 3 23
  4. IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22. (PMID: 18675824) Wu P.W. … Fouser L.A. (J. Mol. Biol. 2008) 3 23
  5. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. (PMID: 15201862) Weiss B. … Sabat R. (Genes Immun. 2004) 3 23

Products for IL22RA2 Gene

Sources for IL22RA2 Gene

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