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IL22RA1 Gene

protein-coding   GIFtS: 55
GCID: GC01M024446

Interleukin 22 Receptor, Alpha 1

(Previous name: interleukin 22 receptor)
(Previous symbol: IL22R)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 22 Receptor, Alpha 11 2     IL-22 Receptor Subunit Alpha-12 3
IL22R1 2 3     Interleukin 22 Receptor1
Cytokine Receptor Class-II Member 92 3     IL22R12
Cytokine Receptor Family 2 Member 92 3     Interleukin-22 Receptor Subunit Alpha-12
CRF2-92 3     zcytoR112
IL-22R-alpha-12 3     ZcytoR113
IL-22RA12 3     

External Ids:    HGNC: 137001   Entrez Gene: 589852   Ensembl: ENSG000001426777   OMIM: 6054575   UniProtKB: Q8N6P73   
ORGUL members:         

Export aliases for IL22RA1 gene to outside databases

Previous GC identifers: GC01M023516 GC01M023797 GC01M024191 GC01M024318 GC01M022699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL22RA1 Gene:
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a
receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and
interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10
(IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the
chromosomal region 1p36. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL22RA1 Gene:
IL22RA1 (interleukin 22 receptor, alpha 1) is a protein-coding gene. GO annotations related to this gene include interleukin-20 binding and interferon receptor activity. An important paralog of this gene is IL22RA2.

UniProtKB/Swiss-Prot: I22R1_HUMAN, Q8N6P7
Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and
IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases
pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through
STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell
tube formation and differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL22RA1 gene promoter:
         NF-1   NRSF form 1   MyoD   STAT5A   NRSF form 2   GATA-2   E47   HEN1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL22RA1 promoter sequence
   Search Chromatin IP Primers for IL22RA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL22RA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

IL22RA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL22RA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M024446:  view genomic region     (about GC identifiers)

Start:
24,446,261 bp from pter      End:
24,469,775 bp from pter
Size:
23,515 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: I22R1_HUMAN, Q8N6P7 (See protein sequence)
Recommended Name: Interleukin-22 receptor subunit alpha-1 precursor  
Size: 574 amino acids; 63077 Da
Subunit: Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1
alone
Miscellaneous: Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated
with decreased expression of IL22RA1
2 PDB 3D structures from and Proteopedia for IL22RA1:
3DGC (3D)        3DLQ (3D)    
Secondary accessions: A8K839 B2R9Y9 Q9HB22

Explore the universe of human proteins at neXtProt for IL22RA1: NX_Q8N6P7

Explore proteomics data for IL22RA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn80, Asn172
  • Modification sites at PhosphoSitePlus

  • See IL22RA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067081.2  
    ENSEMBL proteins: 
     ENSP00000270800  

    IL22RA1 Human Recombinant Protein Products:

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    antibodies-online proteins for IL22RA1 (5 products) 

     
    antibodies-online peptides for IL22RA1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 22 receptor, alpha1 subunit
    IL-10 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8N6P7

    ProtoNet protein and cluster: Q8N6P7

    UniProtKB/Swiss-Prot: I22R1_HUMAN, Q8N6P7
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 2 fibronectin type-III domains


    Find genes that share domains with IL22RA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I22R1_HUMAN, Q8N6P7
    Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and
    IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases
    pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through
    STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell
    tube formation and differentiation
    Induction: By IFNG/IFN-gamma in keratinocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004904interferon receptor activity TAS10875937
    GO:0005515protein binding ----
    GO:0042015interleukin-20 binding IEA--
         
    Find genes that share ontologies with IL22RA1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il22ra1):
     immune system  integument  pigmentation 

    Find genes that share phenotypes with IL22RA1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IL22RA1

    miRNA
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    miRTarBase miRNAs that target IL22RA1:
    hsa-mir-26b-5p (MIRT029697)

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    5 qRT-PCR Assays for microRNAs that regulate IL22RA1:
    hsa-miR-579 hsa-miR-492 hsa-miR-324-3p hsa-miR-3652 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL22RA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat IL22RA1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I22R1_HUMAN, Q8N6P7: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL22RA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL22RA1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Immune response Antigen presentation by MHC class II
    Immune response IL 22 signaling pathway0.31
    IL-22 Pathway0.00
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with IL22RA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL22RA1 (see all 8)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    MAPK Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for IL22RA1
        Immune response IL-22 signaling pathway



    2 Kegg Pathways  (Kegg details for IL22RA1):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including IL22RA1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL22RA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for IL22RA1 (Q8N6P72, 3 ENSP000002708004) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL22Q9GZX62, 3, ENSP000003293844MINT-6693956 I2D: score=4 STRING: ENSP00000329384
    PTPN11Q061243I2D: score=1 
    CBLENSP000002640334STRING: ENSP00000264033
    CBLBENSP000002641224STRING: ENSP00000264122
    CBLCENSP000002702794STRING: ENSP00000270279
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0019221cytokine-mediated signaling pathway TAS10875937
    GO:0050829defense response to Gram-negative bacterium IEA--

    Find genes that share ontologies with IL22RA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL22RA1 (I22R1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL22RA1 gene: 
    NM_021258.3  

    Unigene Cluster for IL22RA1:

    Interleukin 22 receptor, alpha 1
    Hs.110915  [show with all ESTs]
    Unigene Representative Sequence: NM_021258
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000270800(uc010oeg.1 uc001biq.2 uc009vrb.2 uc010oeh.2)

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    5 qRT-PCR Assays for microRNAs that regulate IL22RA1:
    hsa-miR-579 hsa-miR-492 hsa-miR-324-3p hsa-miR-3652 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL22RA1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat IL22RA1
      QuantiFast Probe-based Assays in human, mouse, rat IL22RA1

    Additional mRNA sequence: 

    AF286095.1 AK226001.1 AK292204.1 AK304454.1 AK308522.1 AK313971.1 BC014096.2 BC029273.1 

    2 DOTS entries:

    DT.401047  DT.121348143 

    Selected AceView cDNA sequences (see all 26):

    BU952639 NM_021258 BM853402 AW339181 BC029273 BC014096 BM710027 BU950871 
    AI471705 BX089163 BX507144 AA587170 BG679018 AF286095 BF793742 CD630822 
    BI836658 AW859485 BG822815 AA132964 AI660842 BF509148 CD630819 AI473318 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL22RA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                          -                                 
    SP2:                                                            


    ECgene alternative splicing isoforms for IL22RA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL22RA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL22RA1 Expression
    About this image

    IL22RA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL22RA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.110915

    UniProtKB/Swiss-Prot: I22R1_HUMAN, Q8N6P7
    Tissue specificity: Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as
    monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion.
    Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly
    expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in
    synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients

        Pathway & Disease-focused RT2 Profiler PCR Array including IL22RA1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22RA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL22RA1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il22ra11 , 5 interleukin 22 receptor, alpha 11, 5 78.4(n)1
    72.82(a)1
      4 (67.99 cM)5
    2308281  NM_178257.21  NP_839988.11 
     1357281725 
    chicken
    (Gallus gallus)
    Aves IL22RA11 interleukin 22 receptor, alpha 1 47.31(n)
    36.62(a)
      419692  XM_417840.2  XP_417840.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL22RA16
    interleukin 22 receptor, alpha 1
    35(a)
    1 ↔ 1
    GL344299.1(23704-42134)


    ENSEMBL Gene Tree for IL22RA1 (if available)
    TreeFam Gene Tree for IL22RA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL22RA1 gene
    IL22RA22  IL20RA2  

    Find genes that share paralogs with IL22RA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL22RA1 (see all 664)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448091551,2
    C--24445942(+) ACAGAA/GTGTGC 1 -- ds50010--------
    rs1513055141,2
    --24446018(+) ACCCAC/TAATGG 1 -- ds50010--------
    rs1884467091,2
    --24446034(+) GCCTAC/TGATCT 1 -- ds50010--------
    rs1152890361,2
    C,F--24446036(+) CTACGA/GTCTCA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs107946651,2
    C,F,A,H--24446128(+) CCTCTG/AGCTTT 1 -- ds500121Minor allele frequency- A:0.38NS EA NA WA 2348
    rs740635051,2
    C,F--24446141(+) CTGTCC/TTGAGG 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs776391051,2
    C,F--24446164(+) TTTAAG/ACCCAT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1405779031,2
    --24446165(+) TTAAGC/TCCATG 1 -- ds50010--------
    rs1504848091,2
    --24446234(+) GTAACA/GTAGTT 1 -- ds50010--------
    rs1442267991,2
    C--24446240(+) AGTTT-/AAAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for IL22RA1 (24446261 - 24469775 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL22RA1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL22RA1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605457    OMIM disorders: --


    Find genes that share disorders with IL22RA1           About GenesLikeMe

    Genetic Association Database (GAD): IL22RA1
    Human Genome Epidemiology (HuGE) Navigator: IL22RA1 (4 documents)

    Export disorders for IL22RA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL22RA1 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with IL22RA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PubMed id 10875937)1, 2, 3 Xie M.-H.... Gurney A.L. (J. Biol. Chem. 2000)
    2. Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis. (PubMed id 19393422)1, 4, 9 Endam L.M....Desrosiers M. (Otolaryngol Head Neck Surg 2009)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism. (PubMed id 18675809)1, 2 Bleicher L.... Polikarpov I. (FEBS Lett. 2008)
    5. Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor. (PubMed id 17906500)1, 2 Ramanathan M. Jr.... Lane A.P. (Laryngoscope 2007)
    6. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL- TIF) receptor complexes. (PubMed id 11035029)1, 2 Kotenko S.V.... Pestka S. (J. Biol. Chem. 2001)
    7. Calcipotriol modulates IL-22 receptor expression and keratinocyte proliferation in IL-22-induced epidermal hyperplasia. (PubMed id 23688404)1 Moniaga C.S....Kabashima K. (J. Dermatol. Sci. 2013)
    8. Th17-associated cytokines promote human airway smooth muscle cell proliferation. (PubMed id 22898922)1 Chang Y....Hamid Q. (FASEB J. 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. A novel role for IL-22R1 as a driver of inflammation. (PubMed id 20971950)1 Savan R....Young H.A. (Blood 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58985 HGNC: 13700 AceView: IL22RA1 Ensembl:ENSG00000142677 euGenes: HUgn58985
    ECgene: IL22RA1 Kegg: 58985 H-InvDB: IL22RA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL22RA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL22RA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL22RA1 gene:
    Search GeneIP for patents involving IL22RA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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