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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL22 Gene

protein-coding   GIFtS: 57
GCID: GC12M068642

Interleukin 22

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 221 2     IL-D1102
ILTIF2 3 5     TIFIL-232
IL-10-Related T-Cell-Derived Inducible Factor1 2     TIFa2
Cytokine Zcyto182 3     interleukin-222
IL-222 3     zcyto182
IL-TIF2 3     ZCYTO183
IL-10-Related T-Cell-Derived-Inducible Factor2 3     IL215
IL-212     

External Ids:    HGNC: 149001   Entrez Gene: 506162   Ensembl: ENSG000001273187   OMIM: 6053305   UniProtKB: Q9GZX63   

Export aliases for IL22 gene to outside databases

Previous GC identifers: GC12M068157 GC12M068446 GC12M068358 GC12M066928 GC12M065693


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IL22 Gene: 
IL22 (interleukin 22) is a protein-coding gene. Diseases associated with IL22 include chronic mucocutaneous candidiasis, and candidiasis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine activity and interleukin-22 receptor binding.

UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6
Function: Cytokine that contributes to the inflammatory response in vivo

Gene Wiki entry for IL22 (Interleukin 22) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL22 gene promoter:
         AP-1   Brachyury   ATF-2   CUTL1   STAT5A   Evi-1   AREB6   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL22 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

IL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL22 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M068642:  view genomic region     (about GC identifiers)

Start:
68,642,022 bp from pter      End:
68,647,387 bp from pter
Size:
5,366 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6 (See protein sequence)
Recommended Name: Interleukin-22 precursor  
Size: 179 amino acids; 20011 Da
Subcellular location: Secreted
6 PDB 3D structures from and Proteopedia for IL22:
1M4R (3D)        1YKB (3D)        3DGC (3D)        3DLQ (3D)        3G9V (3D)        3Q1S (3D)    

Explore the universe of human proteins at neXtProt for IL22: NX_Q9GZX6

Explore proteomics data for IL22 at MOPED 

IL22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL22 Protein Expression

REFSEQ proteins: NP_065386.1  
ENSEMBL proteins: 
 ENSP00000442424   ENSP00000329384  

Human Recombinant Protein Products for IL22: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL22 (IL-22)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for IL22
OriGene Protein Over-expression Lysate for IL22
OriGene MassSpec for IL22 
OriGene Custom Protein Services for IL22
GenScript Purified and Recombinant Proteins for IL22
Novus Biologicals IL22 Proteins
Novus Biologicals IL22 Lysate
Sino Biological Recombinant Protein for IL22
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for IL22
Cloud-Clone Corp. Proteins for IL22 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IC10875937
GO:0005615extracellular space IEA--

IL22 for ontologies           About GeneDecksing



IL22 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IL22
R&D Systems Antibodies for IL22 (IL-22)
OriGene Antibodies for IL22
OriGene Custom Antibody Services for IL22
GenScript Custom Superior Antibodies Services for IL22
Novus Biologicals IL22 Antibodies
Abcam antibodies for IL22
Cloud-Clone Corp. Antibodies for IL22 
ThermoFisher Antibodies for IL22
LSBio Antibodies in human, mouse, rat for IL22 

Assay Products for IL22: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL22
R&D Systems Flow Cytometry Kits for IL22 (IL-22)         (see all)
GenScript Custom Assay Services for IL22
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL22 
Cloud-Clone Corp. CLIAs for IL22


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

4 InterPro protein domains:
 IPR020453 Interleukin-22
 IPR012351 4_helix_cytokine_core
 IPR020423 Interleukin-10_CS
 IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry Q9GZX6

ProtoNet protein and cluster: Q9GZX6

UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6
Similarity: Belongs to the IL-10 family


IL22 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL22_HUMAN, Q9GZX6
Function: Cytokine that contributes to the inflammatory response in vivo

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0045518interleukin-22 receptor binding NAS10875937
     
IL22 for ontologies           About GeneDecksing


Phenotypes:
     12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il22):
 digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
 homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
 respiratory system  tumorigenesis 

IL22 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL22: Il22tm1Jcrd Il22tm1Lex

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL22 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL22

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL22 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL22 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL22
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL22:
hsa-miR-3163 hsa-miR-3688-3p hsa-miR-944
SwitchGear 3'UTR luciferase reporter plasmidIL22 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL22
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL22

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL22
Sirion Biotech Customized adenovirus for overexpression of IL22

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL22 (see all 7)
OriGene ORF clones in mouse, rat for IL22
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL22 (NM_020525)
Sino Biological Human cDNA Clone for IL22
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL22
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22
Sirion Biotech Customized lentivirus for stable overexpression of IL22 
                     Customized lentivirus expression plasmids for stable overexpression of IL22 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL22
Search LifeMap BioReagents cell lines for IL22
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL22 About   (see all 11)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
3Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
4Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
5PAK Pathway
PAK Pathway0.56
Antioxidant Action of Vitamin-C0.56

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for IL22
    Immune response IL-9 signaling pathway
Immune response IL-22 signaling pathway

2 R&D Systems Pathways for IL22
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
Th17 Differentiation

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL22 (see all 25)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Tec Kinases Signaling

2 GeneGo (Thomson Reuters) Pathways for IL22
    Immune response IL-22 signaling pathway
Immune response IL-9 signaling pathway



3         Kegg Pathways  (Kegg details for IL22):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Inflammatory bowel disease (IBD)


IL22 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL22

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for IL22 (Q9GZX62, 3 ENSP000003293844) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
IL22RA1Q8N6P72, 3, ENSP000002708004MINT-6693956 I2D: score=4 STRING: ENSP00000270800
IL22RA2Q969J52, 3, ENSP000002969804MINT-7010533 I2D: score=4 STRING: ENSP00000296980
IL10RBQ083343, ENSP000002902004I2D: score=2 STRING: ENSP00000290200
IFNAR2P485513I2D: score=1 
IGHG1ENSP000003749904STRING: ENSP00000374990
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006953acute-phase response NAS11481447
GO:0006954inflammatory response NAS10954742
GO:0007267cell-cell signaling IC10875937

IL22 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL22 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL22

1 Novoseek inferred chemical compound relationship for IL22 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen 3.65 1 12700595 (1)

Search CenterWatch for drugs/clinical trials and news about IL22

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL22 gene: 
NM_020525.4  

Unigene Cluster for IL22:

Interleukin 22
Hs.287369  [show with all ESTs]
Unigene Representative Sequence: BC070261
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000538666(uc010stb.1) ENST00000328087(uc001sty.1)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL22
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL22:
hsa-miR-3163 hsa-miR-3688-3p hsa-miR-944
SwitchGear 3'UTR luciferase reporter plasmidIL22 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL22
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL22
Clone
Products:
     
OriGene clones in human, mouse for IL22 (see all 7)
OriGene ORF clones in mouse, rat for IL22
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL22 (NM_020525)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL22
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22
Sirion Biotech Customized lentivirus for stable overexpression of IL22 
                     Customized lentivirus expression plasmids for stable overexpression of IL22 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL22
OriGene qSTAR qPCR primer pairs in human, mouse for IL22
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL22
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL22
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL22

Additional mRNA sequence: 

AF279437.1 AJ277247.1 AY358890.1 BC066263.1 BC066264.1 BC066265.1 BC066266.1 BC067509.1 
BC067510.1 BC069112.1 BC069308.1 BC070261.1 

1 DOTS entry:

DT.100693223 

24/25 AceView cDNA sequences (see all 25):

BC066263 NM_020525 BC070261 BC067510 AF279437 AY358890 BC069308 CD638517 
CD639311 BC067509 BC066265 BC066266 CD639876 BC069112 BC066264 AJ277247 
CD523070 CD559620 CD521138 CD559616 CD559615 CD559621 CD559618 CD559617 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTATTTGAC
IL22 Expression
About this image


See IL22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL22

SOURCE GeneReport for Unigene cluster: Hs.287369
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL22 (see all 6): 
          Th17 Response in human mouse rat
          Oxidative Stress in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL22
OriGene qSTAR qPCR primer pairs in human, mouse for IL22
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL22
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL22
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL22
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL22 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il221 , 5 interleukin 221, 5 80.82(n)1
78.21(a)1
  10 (66.67 cM)5
509291  NM_016971.21  NP_058667.11 
 1182049425 
chicken
(Gallus gallus)
Aves IL221 interleukin 22 56.93(n)
43.26(a)
  417838  NM_001199614.1  NP_001186543.1 
lizard
(Anolis carolinensis)
Reptilia IL226
Uncharacterized protein
34(a)
1 ↔ 1
GL343256.1(1206499-1211123)


ENSEMBL Gene Tree for IL22 (if available)
TreeFam Gene Tree for IL22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/195 SNPs in IL22 are shown (see all 195)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs11828441,2
C,F,A,H--68641532(+) GTAGGT/AATGAC 1 -- ds500122Minor allele frequency- A:0.35NS EA NA WA 1714
rs787116881,2
C--68641581(+) CTTTCA/GGGGAT 1 -- ds50011Minor allele frequency- G:0.01WA 118
rs22275101,2
C,F,O,H--68641587(-) TCCAGT/CATCCC 1 -- ds500112Minor allele frequency- C:0.03NS EA NA 774
rs1923073721,2
--68641590(+) ATACTG/TGAGAG 1 -- ds50010--------
rs22275091,2
C,F,H--68641610(-) CAGGCC/ATACTG 1 -- ds50019Minor allele frequency- A:0.01NS EA NA 632
rs22275081,2
C,F,O,H--68641928(-) CTAAGA/TAAATG 1 -- ds500128Minor allele frequency- T:0.13NS EA NA 2950
rs1841262131,2
--68642093(+) TATCAA/GTATTA 1 -- ut310--------
rs1436906111,2
--68642179(+) TGCAGA/TCTTAT 1 -- ut310--------
rs356271501,2
C--68642217(+) AAAGTA/CCTGAT 1 -- ut311Minor allele frequency- C:0.00NA 2
rs1889194501,2
C--68642324(+) TTTCTG/TTGTAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for IL22 (68642022 - 68647387 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IL22:    About this table     
Variant IDTypeSubtypePubMed ID
nsv899224CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL22
DNA2.0 Custom Variant and Variant Library Synthesis for IL22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605330    OMIM disorders: --

20/42 diseases for IL22 (see all 42):    About MalaCards
chronic mucocutaneous candidiasis    candidiasis    acne    ankylosing spondylitis
acute graft versus host disease    allergic asthma    anaplastic large cell lymphoma    psoriasis
ulcerative colitis    guillain-barre syndrome    crohn's disease    skin disease
spondylitis    graft versus host disease    acute pancreatitis    pneumonia
inflammatory bowel disease    celiac disease    uveitis    thrombocytopenia

2 diseases from the University of Copenhagen DISEASES database for IL22:
Psoriasis     Chronic mucocutaneous candidiasis

IL22 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/19 Novoseek inferred disease relationships for IL22 gene (see all 19)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 58.4 21 18060647 (3), 19469905 (3), 17900301 (2), 19295614 (1) (see all 9)
inflammation 54.1 22 17187052 (2), 18172556 (2), 15120652 (1), 17442982 (1) (see all 17)
acanthosis 50.8 5 17187052 (3), 17277128 (1), 18202747 (1)
response acute phase 50.5 5 15120653 (1), 15818686 (1), 18675809 (1)
autoimmunity 48.3 1 19481975 (1)
inflammatory bowel diseases 44.7 2 16143135 (1), 18172556 (1)
autoimmune diseases 44.3 2 17187052 (1), 18675824 (1)
colitis ulcerative 41.6 2 20065946 (1), 18172556 (1)
necrosis 32.7 11 19295614 (1), 16212920 (1), 18973545 (1), 19704117 (1) (see all 9)
skin diseases 31.5 1 15308104 (1)

Genetic Association Database (GAD): IL22
Human Genome Epidemiology (HuGE) Navigator: IL22 (10 documents)

Export disorders for IL22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL22 gene, integrated from 9 sources (see all 263):
(articles sorted by number of sources associating them with IL22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte- stimulating factor. (PubMed id 10954742)1, 2, 3, 9 Dumoutier L.... Renauld J.-C. (2000)
  2. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PubMed id 10875937)1, 2, 3, 9 Xie M.H....Gurney A.L. (2000)
  3. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. (PubMed id 17845543)1, 4, 9 Hennig B.J....Hill A.V. (2007)
  4. Common polymorphisms in the interleukin-22 gene are n ot associated with chronic plaque psoriasis. (PubMed id 19469905)1, 4, 9 Weger W....Salmhofer W. (2009)
  5. Structure of IL-22 bound to its high-affinity IL-22R1 chain. (PubMed id 18599299)1, 2, 9 Jones B.C.... Walter M.R. (2008)
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  7. Crystallization and synchrotron X-ray diffraction studies of human interleukin-22. (PubMed id 11856845)1, 2, 9 Nagem R.A....Polikarpov I. (2002)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 50616 HGNC: 14900 AceView: IL22 Ensembl:ENSG00000127318 euGenes: HUgn50616
ECgene: IL22 Kegg: 50616 H-InvDB: IL22

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL22 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL22 Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPshttp://pga.gs.washington.edu/data/il22/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL22 gene:
Search GeneIP for patents involving IL22

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