Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL22 Gene

protein-coding   GIFtS: 55
GCID: GC12M068642

interleukin 22

 Explore 42 diseases affiliated with
IL22 via our new
 Human Malady Compendium 
Biological research products
for IL22
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 221 2     Cytokine Zcyto182 3
ILTIF1 2 3 5     IL-10-Related T-Cell-Derived-Inducible Factor2 3
IL-221 2 3     MGC793821
IL-TIF1 2 3     MGC793841
IL-211 2     IL-10-Related T-Cell-Derived Inducible Factor2
IL-D1101 2     Interleukin-221
TIFIL-231 2     ZCYTO183
TIFa1 2     IL215
Zcyto181     

External Ids:    HGNC: 149001   Entrez Gene: 506162   Ensembl: ENSG000001273187   OMIM: 6053305   UniProtKB: Q9GZX63   

Export aliases for IL22 gene to outside databases

Previous GC identifers: GC12M068157 GC12M068446 GC12M068358 GC12M066928 GC12M065693


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6
Function: Cytokine that contributes to the inflammatory response in vivo

Gene Wiki entry for IL22 (Interleukin 22)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL22 gene promoter:
         AP-1   Brachyury   ATF-2   CUTL1   STAT5A   Evi-1   AREB6   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL22 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

IL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL22 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M068642:  view genomic region     (about GC identifiers)

Start:
68,642,022 bp from pter      End:
68,647,387 bp from pter
Size:
5,366 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6 (See protein sequence)
Recommended Name: Interleukin-22 precursor  
Size: 179 amino acids; 20011 Da
Subcellular location: Secreted
6 PDB 3D structures from and Proteopedia for IL22:
1M4R (3D)        1YKB (3D)        3DGC (3D)        3DLQ (3D)        3G9V (3D)        3Q1S (3D)    

Explore the universe of human proteins at neXtProt for IL22: NX_Q9GZX6

IL22 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_065386.1  
ENSEMBL proteins: 
 ENSP00000442424   ENSP00000329384  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL22 (IL-22)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: IL22
OriGene Protein Over-expression Lysate: IL22
OriGene Custom Protein Services for IL22 
GenScript Purified and Recombinant Proteins for IL22
Novus Biologicals IL22 Proteins
Novus Biologicals IL22 Lysate
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for IL22
Uscn Proteins for IL22

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IC10875937
GO:0005615extracellular space IEA--


IL22 for ontologies           About GeneDecksing



IL22 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IL22
R&D Systems Antibodies for IL22 (IL-22)
OriGene Antibodies: IL22
OriGene Custom Antibody Services for IL22 
GenScript Custom Superior Antibodies Services for IL22
Novus Biologicals IL22 Antibodies
Abcam antibodies for IL22 
Uscn Antibodies for IL22
ThermoFisher Antibodies for IL22

Assay Products for IL22: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
R&D Systems Flow Cytometry Kits for IL22 (IL-22)         (see all)
GenScript Custom Assay Services for IL22
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for IL22


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL22 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR020453 Interleukin-22
 IPR009079 4_helix_cytokine-like_core
 IPR012351 4_helix_cytokine_core
 IPR020423 Interleukin-10_CS

Graphical View of Domain Structure for InterPro Entry Q9GZX6

ProtoNet protein and cluster: Q9GZX6

UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6
Similarity: Belongs to the IL-10 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6
Function: Cytokine that contributes to the inflammatory response in vivo

miRNA
Products:
    
Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL22
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL22:
hsa-miR-3163 hsa-miR-3688-3p hsa-miR-944
SwitchGear 3'UTR luciferase reporter plasmidIL22 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL22 (see all 4)
OriGene shRNA RFP: IL22
OriGene siRNA: IL22
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL22

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL22

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL22 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: IL22 (NM_020525)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL22
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL22
Search LifeMap BioReagents cell lines for IL22

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0045518interleukin-22 receptor binding NAS10875937


IL22 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-outs for IL22: Il22tm1Jcrd Il22tm1Lex
     11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il22):
 digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism 
 immune system  integument  liver/biliary system  mortality/aging  respiratory system 
 tumorigenesis 

IL22 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1PEDF Induced Signaling
8/12 pathways (see all 12)
PEDF Induced Signaling1.00
STAT3 Pathway0.47
MIF Mediated Glucocorticoid Regulation0.73
Endothelin-1 Signaling Pathway0.44
MIF Regulation of Innate Immune Cells0.71
NFAT Signaling and Lymphocyte Interactions0.37
IL-6 Pathway0.61
PGC1Alpha Pathway0.33
2TGF-Beta Pathway
TGF-Beta Pathway1.00
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.29
JAK-STAT Pathway0.57
3Akt Signaling
Akt Signaling1.00
Tec Kinases Signaling0.55
p38 Signaling0.60
4Rho Family GTPases
Rho Family GTPases1.00
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
5Immune response IL-22 signaling pathway
Immune response IL-22 signaling pathway1.00
Immune response_IL-22 signaling pathway0.87

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IL22
    Immune response IL-9 signaling pathway
Immune response IL-22 signaling pathway

2 R&D Systems Pathways for IL22
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
Th17 Differentiation

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL22 (see all 25)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Tec Kinases Signaling

2 GeneGo (Thomson Reuters) Pathways for IL22
    Immune response IL-22 signaling pathway
Immune response IL-9 signaling pathway


2         Kegg Pathways  (Kegg details for IL22):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway


IL22 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL22

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for IL22 (Q9GZX62, 3 ENSP000003293844) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
IL22RA1Q8N6P72, 3, ENSP000002708004MINT-6693956 I2D: score=4 STRING: ENSP00000270800
IL22RA2Q969J52, 3, ENSP000002969804MINT-7010533 I2D: score=4 STRING: ENSP00000296980
IL10RBQ083343, ENSP000002902004I2D: score=2 STRING: ENSP00000290200
IFNAR2P485513I2D: score=1 
IGHG1ENSP000003749904STRING: ENSP00000374990
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006953acute-phase response NAS11481447
GO:0006954inflammatory response NAS10954742
GO:0007267cell-cell signaling IC10875937


IL22 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL22 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL22
1 Novoseek chemical compound relationship for IL22 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen 3.65 1 12700595 (1)

Search CenterWatch for drugs/clinical trials and news about IL22 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL22 gene: 
NM_020525.4  

Unigene Cluster for IL22:

Interleukin 22
Hs.287369  [show with all ESTs]
Unigene Representative Sequence: BC070261
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000538666(uc010stb.1) ENST00000328087(uc001sty.1)

miRNA
Products:
     
Browse 3'-UTR reporter clones for miRNA target validation
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL22
3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL22:
hsa-miR-3163 hsa-miR-3688-3p hsa-miR-944
SwitchGear 3'UTR luciferase reporter plasmidIL22 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL22 (see all 4)
OriGene shRNA RFP: IL22
OriGene siRNA: IL22
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL22
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL22 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: IL22 (NM_020525)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL22
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL22
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL22
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL22
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL22

Additional cDNA sequence: 

AF279437.1 AJ277247.1 AY358890.1 BC066263.1 BC066264.1 BC066265.1 BC066266.1 BC067509.1 
BC067510.1 BC069112.1 BC069308.1 BC070261.1 

1 DOTS entry:

DT.100693223 

24/25 AceView cDNA sequences (see all 25):

AY358890 BC069308 BC066263 BC070261 AF279437 BC067510 NM_020525 BC066264 
CD638517 CD639311 AJ277247 BC067509 CD523070 BC066266 BC069112 CD639876 
BC066265 CD559620 CD521138 CD559618 CD559616 CD559621 CD559617 CD559615 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATTTGAC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See IL22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL22

SOURCE GeneReport for Unigene cluster: Hs.287369
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL22 (see all 6): 
          Th17 Response in human mouse rat
          Oxidative Stress in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat

Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL22
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL22
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL22
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL22
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL22 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il221 , 5 interleukin 221, 5 80.82(n)1
78.21(a)1
  10 (66.67 cM)5
509291  NM_016971.21  NP_058667.11 
 1182049425 
chicken
(Gallus gallus)
Aves IL221 interleukin 22 56.93(n)
43.26(a)
  417838  NM_001199614.1  NP_001186543.1 
lizard
(Anolis carolinensis)
Reptilia IL226
--
34(a)
1 ↔ 1
GL343256.1(1206499-1211123)


ENSEMBL Gene Tree for IL22 (if available)
TreeFam Gene Tree for IL22 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/156 NCBI SNPs in IL22 are shown (see all 156    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs11828441,2
C,F,A,H,--68641532(+) GTAGGT/AATGAC 1 -- ds500122Minor allele frequency- A:0.35NS EA NA WA 1714
rs787116881,2
C,--68641581(+) CTTTCA/GGGGAT 1 -- ds50011Minor allele frequency- G:0.01WA 118
rs22275101,2
C,F,O,H,--68641587(-) TCCAGT/CATCCC 1 -- ds500112Minor allele frequency- C:0.03NS EA NA 774
rs1923073721,2
--68641590(+) ATACTG/TGAGAG 1 -- ds50010--------
rs22275091,2
C,F,H,--68641610(-) CAGGCC/ATACTG 1 -- ds50019Minor allele frequency- A:0.01NS EA NA 632
rs22275081,2
C,F,O,H,--68641928(-) CTAAGA/TAAATG 1 -- ds500128Minor allele frequency- T:0.13NS EA NA 2950
rs1841262131,2
--68642093(+) TATCAA/GTATTA 1 -- ut310--------
rs1436906111,2
--68642179(+) TGCAGA/TCTTAT 1 -- ut310--------
rs356271501,2
C--68642217(+) AAAGTA/CCTGAT 1 -- ut311Minor allele frequency- C:0.00NA 2
rs1889194501,2
C,--68642324(+) TTTCTG/TTGTAT 1 -- ut310--------

HapMap Linkage Disequilibrium report for IL22 (68642022 - 68647387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for IL22: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL22
DNA2.0 Custom Variant and Variant Library Synthesis for IL22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL22 for disorders           About GeneDecksing

OMIM gene information: 605330    OMIM disorders: --

20/42 diseases for IL22 (see all 42):    About MalaCards
graft versus host disease    chronic mucocutaneous candidiasis    anaplastic large cell lymphoma    inflammatory bowel disease
chronic obstructive pulmonary disease    ankylosing spondylitis    systemic lupus erythematosus    lupus erythematosus
atopic dermatitis    candidiasis    rheumatoid arthritis    allergic asthma
skin disease    ulcerative colitis    spondylitis    bronchiolitis
liver disease    pulmonary disease    celiac disease    acne

2 diseases from the University of Copenhagen DISEASES database for IL22:
Psoriasis     Chronic mucocutaneous candidiasis

10/19 Novoseek disease relationships for IL22 gene (see all 19)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 58.4 21 18060647 (3), 19469905 (3), 17900301 (2), 19295614 (1) (see all 9)
inflammation 54.1 22 17187052 (2), 18172556 (2), 15120652 (1), 17442982 (1) (see all 17)
acanthosis 50.8 5 17187052 (3), 17277128 (1), 18202747 (1)
response acute phase 50.5 5 15120653 (1), 15818686 (1), 18675809 (1)
autoimmunity 48.3 1 19481975 (1)
inflammatory bowel diseases 44.7 2 16143135 (1), 18172556 (1)
autoimmune diseases 44.3 2 17187052 (1), 18675824 (1)
colitis ulcerative 41.6 2 20065946 (1), 18172556 (1)
necrosis 32.7 11 19295614 (1), 16212920 (1), 18973545 (1), 19704117 (1) (see all 9)
skin diseases 31.5 1 15308104 (1)

Human Genome Epidemiology (HuGE) Navigator: IL22 (10 documents)

Export disorders for IL22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL22 gene, integrated from 9 sources (see all 238):
(articles sorted by number of sources associating them with IL22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte- stimulating factor. (PubMed id 10954742)1, 2, 3, 9 Dumoutier L.... Renauld J.-C. (2000)
  2. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PubMed id 10875937)1, 2, 3, 9 Xie M.H....Gurney A.L. (2000)
  3. Structure of IL-22 bound to its high-affinity IL-22R1 chain. (PubMed id 18599299)1, 2, 9 Jones B.C.... Walter M.R. (2008)
  4. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. (PubMed id 11197690)1, 2, 9 Dumoutier L....Renauld J.-C. (2000)
  5. Crystallization and synchrotron X-ray diffraction studies of human interleukin-22. (PubMed id 11856845)1, 2, 9 Nagem R.A....Polikarpov I. (2002)
  6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  9. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. (PubMed id 16143135)1, 9 Andoh A....Fujiyama Y. (2005)
  10. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. (PubMed id 15122762)1, 9 Radaeva S....Gao B. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 50616 HGNC: 14900 AceView: IL22 Ensembl:ENSG00000127318 euGenes: HUgn50616
ECgene: IL22 Kegg: 50616 H-InvDB: IL22

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL22 Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/il22/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IL22 gene:
Search GeneIP for patents involving IL22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 Browse Kits and Assays available from EMD Millipore
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Small Molecules at EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of IL22
 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 Browse for Gene Knock-down Tools from EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for IL22 (IL-22)   Browse Cell Culture Products  
 ELISAs for IL22 (IL-22)   Flow Cytometry Kits for IL22 (IL-22)  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for IL22 (IL-22)  
 OriGene Antibodies for IL22   OriGene shRNA RFP for IL22  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL22   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL22  
 OriGene Protein Over-expression Lysate for IL22   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for IL22   Browse 3'-UTR reporter clones for miRNA target validation  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL22   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL22  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 OriGene Purified Protein for IL22   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for IL22   OriGene Custom Protein Services for IL22  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL22
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL22
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL22
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL22
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL22
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL22
 GenScript Purified and Recombinant Proteins for IL22 GenScript cDNA clones with any tag delivered in your preferred vector for IL22
 GenScript Custom Assay Services for IL22 GenScript Custom Superior Antibodies Services for IL22
 GenScript Custom overexpressing Cell Line Services for IL22 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in IL22 promoter
 Search Chromatin IP Primers for IL22
 RT2 qPCR Primer Assay in human, mouse, rat IL22
 GNC Network for IL22
 SABiosciences PCR Arrays including human, mouse, rat IL22
 Search Tocris compounds for IL22
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 IL22 antibodies
 IL22 proteins
 IL22 lysates
 Antibodies for IL22
 See all of Abcam's Antibodies, Kits and Proteins for IL22
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for IL22




 IL22 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for IL22
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22
 SwitchGear 3'UTR luciferase reporter plasmids for IL22
 SwitchGear Promoter luciferase reporter plasmids for IL22
 ThermoFisher Antibodies for IL22
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      IL22 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4