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Aliases for IL22 Gene

Aliases for IL22 Gene

  • Interleukin 22 2 3 5
  • IL-10-Related T-Cell-Derived Inducible Factor 2 3
  • Cytokine Zcyto18 3 4
  • Zcyto18 3 4
  • IL-TIF 3 4
  • IL-22 3 4
  • ILTIF 3 4
  • IL-10-Related T-Cell-Derived-Inducible Factor 4
  • Interleukin-22 3
  • TIFIL-23 3
  • IL-D110 3
  • IL-21 3
  • TIFa 3

External Ids for IL22 Gene

Previous GeneCards Identifiers for IL22 Gene

  • GC12M068157
  • GC12M068446
  • GC12M068358
  • GC12M066928
  • GC12M068642
  • GC12M065693

Summaries for IL22 Gene

GeneCards Summary for IL22 Gene

IL22 (Interleukin 22) is a Protein Coding gene. Diseases associated with IL22 include Acute Generalized Exanthematous Pustulosis and Chronic Mucocutaneous Candidiasis. Among its related pathways are Immune System and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and interleukin-22 receptor binding.

UniProtKB/Swiss-Prot for IL22 Gene

  • Cytokine that contributes to the inflammatory response in vivo.

Gene Wiki entry for IL22 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL22 Gene

Genomics for IL22 Gene

Regulatory Elements for IL22 Gene

Enhancers for IL22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F068311 0.3 FANTOM5 13.4 -57.8 -57829 0.3 PRDM1 IL22 IL26 MDM1 LOC100507195 LOC100130075 MDM2 GC12M068294
GH12F068222 1.2 FANTOM5 Ensembl ENCODE 12.7 +30.4 30432 1.2 ELF3 ATF1 PKNOX1 TBL1XR1 WRNIP1 ARID4B ZNF2 RAD21 RFX5 GATA2 MDM1 IL22 LOC100507195 NUP107 LOC101927901 IL26 GC12P068213
GH12F068312 0.3 FANTOM5 12.6 -58.6 -58613 0.3 MDM1 NUP107 MDM2 IL22 IL26 LOC100507195 LOC100507250 RPL7P42 LOC100130075 SLC35E3
GH12F068277 0.6 Ensembl ENCODE 11.7 -24.4 -24394 0.4 TBL1XR1 BMI1 EBF1 ZFHX2 EGR1 EED ETV6 CREM EGR2 CHD2 IL22 IL26 MDM1 LOC100507195 GC12M068294
GH12F068309 0.2 ENCODE 10.8 -56.9 -56903 1.2 JUND JUN BHLHE40 FOS MAFK IL26 MDM1 LOC100507195 IL22 LOC100130075 MDM2 GC12M068294
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IL22 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL22 Gene

68,248,242 bp from pter
68,253,607 bp from pter
5,366 bases
Minus strand

Genomic View for IL22 Gene

Genes around IL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22 Gene

Proteins for IL22 Gene

  • Protein details for IL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for IL22 Gene

    179 amino acids
    Molecular mass:
    20011 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL22 Gene

neXtProt entry for IL22 Gene

Post-translational modifications for IL22 Gene

  • Glycosylation at Asn 54, Asn 68, and Asn 97
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL22 Gene

Domains & Families for IL22 Gene

Gene Families for IL22 Gene

Suggested Antigen Peptide Sequences for IL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-10 family.
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL22: view

Function for IL22 Gene

Molecular function for IL22 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that contributes to the inflammatory response in vivo.

Gene Ontology (GO) - Molecular Function for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005515 protein binding IPI 12513909
GO:0045518 interleukin-22 receptor binding NAS 10875937
genes like me logo Genes that share ontologies with IL22: view
genes like me logo Genes that share phenotypes with IL22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL22

miRNA for IL22 Gene

miRTarBase miRNAs that target IL22

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL22 Gene

Localization for IL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22 Gene


Subcellular locations from

Jensen Localization Image for IL22 Gene COMPARTMENTS Subcellular localization image for IL22 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with IL22: view

Pathways & Interactions for IL22 Gene

genes like me logo Genes that share pathways with IL22: view

SIGNOR curated interactions for IL22 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response NAS 11481447
GO:0006954 inflammatory response NAS 10954742
GO:0006955 immune response IBA --
GO:0007267 cell-cell signaling IC 10875937
GO:0046427 positive regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with IL22: view

Drugs & Compounds for IL22 Gene

(1) Drugs for IL22 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IL22: view

Transcripts for IL22 Gene

mRNA/cDNA for IL22 Gene

Unigene Clusters for IL22 Gene

Interleukin 22:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL22 Gene

No ASD Table

Relevant External Links for IL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL22 Gene

mRNA expression in normal human tissues for IL22 Gene

mRNA differential expression in normal tissues according to GTEx for IL22 Gene

This gene is overexpressed in Minor Salivary Gland (x21.4) and Esophagus - Mucosa (x6.8).

Protein differential expression in normal tissues from HIPED for IL22 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL22 Gene

Protein tissue co-expression partners for IL22 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL22 Gene:


SOURCE GeneReport for Unigene cluster for IL22 Gene:

genes like me logo Genes that share expression patterns with IL22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IL22 Gene

Orthologs for IL22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL22 34 35
  • 99.63 (n)
(Canis familiaris)
Mammalia IL22 34 35
  • 91.43 (n)
(Mus musculus)
Mammalia Il22 34 35
  • 80.82 (n)
Iltifb 16 35
  • 78 (a)
(Bos Taurus)
Mammalia IL22 34
  • 79.78 (n)
IL-22 35
  • 65 (a)
(Rattus norvegicus)
Mammalia Il22 34
  • 78.96 (n)
(Ornithorhynchus anatinus)
Mammalia IL22 35
  • 38 (a)
(Monodelphis domestica)
Mammalia IL22 35
  • 35 (a)
(Gallus gallus)
Aves IL22 34 35
  • 58.11 (n)
(Anolis carolinensis)
Reptilia IL22 35
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il22 34
  • 51.8 (n)
Species where no ortholog for IL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL22 Gene

Gene Tree for IL22 (if available)
Gene Tree for IL22 (if available)

Paralogs for IL22 Gene

No data available for Paralogs for IL22 Gene

Variants for IL22 Gene

Sequence variations from dbSNP and Humsavar for IL22 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1012356 -- 68,250,838(+) TAACT(A/T)TAATA intron-variant
rs10699698 -- 68,254,518(+) ATATA(-/AT/TA)CACAC intron-variant, upstream-variant-2KB
rs10784699 -- 68,254,537(+) ACACA(C/T)GGATG intron-variant, upstream-variant-2KB
rs112508009 -- 68,252,132(+) CTCTT(C/T)TAATT intron-variant
rs113389656 -- 68,255,199(+) AAAAT(G/T)TCAAG intron-variant, upstream-variant-2KB

Variation tolerance for IL22 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL22 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL22 Gene

Disorders for IL22 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL22 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IL22 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL22 Gene

Publications for IL22 Gene

  1. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PMID: 10875937) Xie M.-H. … Gurney A.L. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte- stimulating factor. (PMID: 10954742) Dumoutier L. … Renauld J.-C. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 22 64
  3. Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis. (PMID: 19469905) Weger W. … Salmhofer W. (Exp. Dermatol. 2009) 3 22 46 64
  4. Structure of IL-22 bound to its high-affinity IL-22R1 chain. (PMID: 18599299) Jones B.C. … Walter M.R. (Structure 2008) 3 4 22 64
  5. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. (PMID: 17845543) Hennig B.J. … Hill A.V. (Liver Int. 2007) 3 22 46 64

Products for IL22 Gene

Sources for IL22 Gene

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