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IL22 Gene

protein-coding   GIFtS: 59
GCID: GC12M068642

Interleukin 22

  See IL22-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 221 2     IL-D1102
ILTIF2 3 5     TIFIL-232
IL-10-Related T-Cell-Derived Inducible Factor1 2     TIFa2
Cytokine Zcyto182 3     interleukin-222
IL-222 3     zcyto182
IL-TIF2 3     ZCYTO183
IL-10-Related T-Cell-Derived-Inducible Factor2 3     IL215
IL-212     

External Ids:    HGNC: 149001   Entrez Gene: 506162   Ensembl: ENSG000001273187   OMIM: 6053305   UniProtKB: Q9GZX63   

Export aliases for IL22 gene to outside databases

Previous GC identifers: GC12M068157 GC12M068446 GC12M068358 GC12M066928 GC12M065693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IL22 Gene:
IL22 (interleukin 22) is a protein-coding gene. Diseases associated with IL22 include chronic mucocutaneous candidiasis, and acute generalized exanthematous pustulosis. GO annotations related to this gene include cytokine activity and interleukin-22 receptor binding.

UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6
Function: Cytokine that contributes to the inflammatory response in vivo

Gene Wiki entry for IL22 (Interleukin 22) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL22 gene promoter:
         AP-1   Brachyury   ATF-2   CUTL1   STAT5A   Evi-1   AREB6   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL22 promoter sequence
   Search Chromatin IP Primers for IL22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

IL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL22 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M068642:  view genomic region     (about GC identifiers)

Start:
68,642,022 bp from pter      End:
68,647,387 bp from pter
Size:
5,366 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6 (See protein sequence)
Recommended Name: Interleukin-22 precursor  
Size: 179 amino acids; 20011 Da
6 PDB 3D structures from and Proteopedia for IL22:
1M4R (3D)        1YKB (3D)        3DGC (3D)        3DLQ (3D)        3G9V (3D)        3Q1S (3D)    

Explore the universe of human proteins at neXtProt for IL22: NX_Q9GZX6

Explore proteomics data for IL22 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn54, Asn68, Asn97

  • See IL22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065386.1  
    ENSEMBL proteins: 
     ENSP00000442424   ENSP00000329384  

    IL22 Human Recombinant Protein Products:

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    OriGene Purified Protein for IL22
    OriGene Protein Over-expression Lysate for IL22
    OriGene MassSpec for IL22
    OriGene Custom Protein Services for IL22
    GenScript Purified and Recombinant Proteins for IL22
    Novus Biologicals IL22 Proteins
    Novus Biologicals IL22 Lysate
    Sino Biological Recombinant Protein for IL22
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL22
    Cloud-Clone Corp. Proteins for IL22

     
    eBioscience Proteins for IL22: (see all 2
                        Human IL-22 Recombinant Protein Carrier-Free 100 ug

    IL22 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL22
    R&D Systems Antibodies for IL22 (IL-22)
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    Novus Biologicals IL22 Antibodies
    Abcam antibodies for IL22
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    ThermoFisher Antibodies for IL22
    LSBio Antibodies in human, mouse, rat for IL22

    IL22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for IL22 (IL-22)         (see all)
    GenScript Custom Assay Services for IL22
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL22
    Cloud-Clone Corp. CLIAs for IL22
    eBioscience ELISAs for IL22: (see all 2
                        Human IL-22 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR020453 IL-22
     IPR012351 4_helix_cytokine_core
     IPR020423 IL-10_CS
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry Q9GZX6

    ProtoNet protein and cluster: Q9GZX6

    UniProtKB/Swiss-Prot: IL22_HUMAN, Q9GZX6
    Similarity: Belongs to the IL-10 family


    Find genes that share domains with IL22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL22_HUMAN, Q9GZX6
    Function: Cytokine that contributes to the inflammatory response in vivo

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0045518interleukin-22 receptor binding NAS10875937
         
    Find genes that share ontologies with IL22           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il22):
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     no phenotypic analysis  respiratory system  tumorigenesis 

    Find genes that share phenotypes with IL22           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL22: Il22tm1Jcrd Il22tm1Vlcg Il22tm1.1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL22
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL22

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL22:
    hsa-mir-335-5p (MIRT017094)

    Block miRNA regulation of human, mouse, rat IL22 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IL22:
    hsa-miR-3163 hsa-miR-3688-3p hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidIL22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL22
    Predesigned siRNA for gene silencing in human, mouse, rat IL22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL22

    Clone
    Products:
         
    OriGene clones in human, mouse for IL22 (see all 6)
    OriGene ORF clones in mouse, rat for IL22
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    GenScript: all cDNA clones in your preferred vector: IL22 (NM_020525)
    Sino Biological Human cDNA Clone for IL22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL22
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL22_HUMAN, Q9GZX6: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IC10875937
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL22 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Immune response Antigen presentation by MHC class II
    Immune response IL 22 signaling pathway0.31
    IL-22 Pathway0.00
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with IL22           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL22
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL22 (see all 25)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    2 GeneGo (Thomson Reuters) Pathways for IL22
        Immune response IL-22 signaling pathway
    Immune response IL-9 signaling pathway



    3 Kegg Pathways  (Kegg details for IL22):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Inflammatory bowel disease (IBD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL22 (see all 6): 
              Th17 Response in human mouse rat
              Oxidative Stress in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL22

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for IL22 (Q9GZX62, 3 ENSP000003293844) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL22RA1Q8N6P72, 3, ENSP000002708004MINT-6693956 I2D: score=4 STRING: ENSP00000270800
    IL22RA2Q969J52, 3, ENSP000002969804MINT-7010533 I2D: score=4 STRING: ENSP00000296980
    IL10RBQ083343, ENSP000002902004I2D: score=2 STRING: ENSP00000290200
    IFNAR2P485513I2D: score=1 
    IGHG1ENSP000003749904STRING: ENSP00000374990
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006953acute-phase response NAS11481447
    GO:0006954inflammatory response NAS10954742
    GO:0007267cell-cell signaling IC10875937
    GO:0051384response to glucocorticoid IEA--

    Find genes that share ontologies with IL22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL22

    1 Novoseek inferred chemical compound relationship for IL22 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 3.65 1 12700595 (1)



    Find genes that share compounds with IL22           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL22 gene: 
    NM_020525.4  

    Unigene Cluster for IL22:

    Interleukin 22
    Hs.287369  [show with all ESTs]
    Unigene Representative Sequence: BC070261
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538666(uc010stb.1) ENST00000328087(uc001sty.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat IL22 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IL22:
    hsa-miR-3163 hsa-miR-3688-3p hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidIL22 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IL22
    Predesigned siRNA for gene silencing in human, mouse, rat IL22
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    GenScript: all cDNA clones in your preferred vector: IL22 (NM_020525)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL22
    Primer
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    OriGene qPCR primer pairs and template standards for IL22
    OriGene qSTAR qPCR primer pairs in human, mouse for IL22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL22
      QuantiTect SYBR Green Assays in human, mouse, rat IL22
      QuantiFast Probe-based Assays in human, mouse, rat IL22

    Additional mRNA sequence: 

    AF279437.1 AJ277247.1 AY358890.1 BC066263.1 BC066264.1 BC066265.1 BC066266.1 BC067509.1 
    BC067510.1 BC069112.1 BC069308.1 BC070261.1 

    1 DOTS entry:

    DT.100693223 

    Selected AceView cDNA sequences (see all 25):

    BC066263 BC070261 BC069308 AY358890 AF279437 NM_020525 BC067510 BC069112 
    BC066266 CD638517 BC066264 AJ277247 CD639876 BC066265 CD639311 BC067509 
    CD523070 CD559620 CD559616 CD559615 CD559617 CD559618 CD559621 CD521138 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTTGAC
    IL22 Expression
    About this image

    IL22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287369
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL22 (see all 6): 
              Th17 Response in human mouse rat
              Oxidative Stress in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IL22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL22 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il221 , 5 interleukin 221, 5 80.82(n)1
    78.21(a)1
      10 (66.67 cM)5
    509291  NM_016971.21  NP_058667.11 
     1182049425 
    chicken
    (Gallus gallus)
    Aves IL221 interleukin 22 58.11(n)
    44.59(a)
      417838  NM_001199614.1  NP_001186543.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL226
    interleukin 22
    35(a)
    1 ↔ 1
    GL343256.1(1206499-1211123)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il221 interleukin-22 51.8(n)
    38.85(a)
      100216308  NM_001142253.1  NP_001135725.1 


    ENSEMBL Gene Tree for IL22 (if available)
    TreeFam Gene Tree for IL22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL22 (see all 195)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11828441,2
    C,F,A,H--68641532(+) GTAGGT/AATGAC 1 -- ds500122Minor allele frequency- A:0.35NS EA NA WA 1714
    rs787116881,2
    C--68641581(+) CTTTCA/GGGGAT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs22275101,2
    C,F,O,H--68641587(-) TCCAGT/CATCCC 1 -- ds500112Minor allele frequency- C:0.03NS EA NA 774
    rs1923073721,2
    --68641590(+) ATACTG/TGAGAG 1 -- ds50010--------
    rs22275091,2
    C,F,H--68641610(-) CAGGCC/ATACTG 1 -- ds50019Minor allele frequency- A:0.01NS EA NA 632
    rs22275081,2
    C,F,O,H--68641928(-) CTAAGA/TAAATG 1 -- ds500128Minor allele frequency- T:0.13NS EA NA 2950
    rs1841262131,2
    --68642093(+) TATCAA/GTATTA 1 -- ut310--------
    rs1436906111,2
    --68642179(+) TGCAGA/TCTTAT 1 -- ut310--------
    rs356271501,2
    C--68642217(+) AAAGTA/CCTGAT 1 -- ut311Minor allele frequency- C:0.00NA 2
    rs1889194501,2
    C--68642324(+) TTTCTG/TTGTAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IL22 (68642022 - 68647387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899224CNV Loss21882294

    Human Gene Mutation Database (HGMD): IL22
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL22
    DNA2.0 Custom Variant and Variant Library Synthesis for IL22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605330    OMIM disorders: --

    4 diseases for IL22:    
    About MalaCards
    chronic mucocutaneous candidiasis    acute generalized exanthematous pustulosis    interstitial lung disease    alcoholic hepatitis

    2 diseases from the University of Copenhagen DISEASES database for IL22:
    Psoriasis     Chronic mucocutaneous candidiasis

    Find genes that share disorders with IL22           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL22 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 58.4 21 18060647 (3), 19469905 (3), 17900301 (2), 19295614 (1) (see all 9)
    inflammation 54.1 22 17187052 (2), 18172556 (2), 15120652 (1), 17442982 (1) (see all 17)
    acanthosis 50.8 5 17187052 (3), 17277128 (1), 18202747 (1)
    response acute phase 50.5 5 15120653 (1), 15818686 (1), 18675809 (1)
    autoimmunity 48.3 1 19481975 (1)
    inflammatory bowel diseases 44.7 2 16143135 (1), 18172556 (1)
    autoimmune diseases 44.3 2 17187052 (1), 18675824 (1)
    colitis ulcerative 41.6 2 20065946 (1), 18172556 (1)
    necrosis 32.7 11 19295614 (1), 16212920 (1), 18973545 (1), 19704117 (1) (see all 9)
    skin diseases 31.5 1 15308104 (1)

    Genetic Association Database (GAD): IL22
    Human Genome Epidemiology (HuGE) Navigator: IL22 (10 documents)

    Export disorders for IL22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL22 gene, integrated from 10 sources (see all 275):
    (articles sorted by number of sources associating them with IL22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte- stimulating factor. (PubMed id 10954742)1, 2, 3, 9 Dumoutier L.... Renauld J.-C. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PubMed id 10875937)1, 2, 3, 9 Xie M.-H.... Gurney A.L. (J. Biol. Chem. 2000)
    3. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. (PubMed id 17845543)1, 4, 9 Hennig B.J....Hill A.V. (Liver Int. 2007)
    4. Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis. (PubMed id 19469905)1, 4, 9 Weger W....Salmhofer W. (Exp. Dermatol. 2009)
    5. Structure of IL-22 bound to its high-affinity IL-22R1 chain. (PubMed id 18599299)1, 2, 9 Jones B.C.... Walter M.R. (Structure 2008)
    6. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. (PubMed id 11197690)1, 2, 9 Dumoutier L....Renauld J.-C. (Genes Immun. 2000)
    7. Crystallization and synchrotron X-ray diffraction studies of human interleukin-22. (PubMed id 11856845)1, 2, 9 Nagem R.A....Polikarpov I. (Acta Crystallogr. D 2002)
    8. Interleukin-22 genetic polymorphisms and risk of colon cancer. (PubMed id 20339910)1, 4 Thompson C.L....Li L. (amp 2010)
    9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    10. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)1, 4 Silverberg M.S....Duerr R.H. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50616 HGNC: 14900 AceView: IL22 Ensembl:ENSG00000127318 euGenes: HUgn50616
    ECgene: IL22 Kegg: 50616 H-InvDB: IL22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL22 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il22/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL22 gene:
    Search GeneIP for patents involving IL22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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