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Aliases for IL21R Gene

Aliases for IL21R Gene

  • Interleukin 21 Receptor 2 3 5
  • Novel Interleukin Receptor 3 4
  • IL-21 Receptor 3 4
  • NILR 3 4
  • CD360 Antigen 4
  • IL-21R 4
  • CD360 3

External Ids for IL21R Gene

Previous GeneCards Identifiers for IL21R Gene

  • GC16P026842
  • GC16P027512
  • GC16P027341
  • GC16P027380
  • GC16P027321
  • GC16P025501

Summaries for IL21R Gene

Entrez Gene Summary for IL21R Gene

  • The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

GeneCards Summary for IL21R Gene

IL21R (Interleukin 21 Receptor) is a Protein Coding gene. Diseases associated with IL21R include Immunodeficiency, Primary, Autosomal Recessive, Il21r-Related and Cryptosporidiosis-Chronic Cholangitis-Liver Disease Syndrome. Among its related pathways are Th17 Differentiation Pathway and Jak-STAT signaling pathway. GO annotations related to this gene include interleukin-21 receptor activity.

UniProtKB/Swiss-Prot for IL21R Gene

  • This is a receptor for interleukin-21.

Gene Wiki entry for IL21R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL21R Gene

Genomics for IL21R Gene

Regulatory Elements for IL21R Gene

Enhancers for IL21R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL21R on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL21R gene promoter:

Genomic Location for IL21R Gene

27,402,162 bp from pter
27,452,042 bp from pter
49,881 bases
Plus strand

Genomic View for IL21R Gene

Genes around IL21R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL21R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL21R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL21R Gene

Proteins for IL21R Gene

  • Protein details for IL21R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-21 receptor
    Protein Accession:
    Secondary Accessions:
    • A8K9E8
    • D3DWF7
    • Q96HZ1
    • Q9HB91

    Protein attributes for IL21R Gene

    538 amino acids
    Molecular mass:
    59130 Da
    Quaternary structure:
    • Heterodimer with the common gamma subunit. Associates with JAK1.

    Three dimensional structures from OCA and Proteopedia for IL21R Gene

neXtProt entry for IL21R Gene

Proteomics data for IL21R Gene at MOPED

Post-translational modifications for IL21R Gene

  • C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
  • Glycosylation at Asn 73, Asn 97, Asn 104, Asn 125, Asn 135, and Trp 214
  • Modification sites at PhosphoSitePlus

Other Protein References for IL21R Gene

Antibody Products

No data available for DME Specific Peptides for IL21R Gene

Domains & Families for IL21R Gene

Gene Families for IL21R Gene

Protein Domains for IL21R Gene

Suggested Antigen Peptide Sequences for IL21R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 2 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
genes like me logo Genes that share domains with IL21R: view

Function for IL21R Gene

Molecular function for IL21R Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for interleukin-21.
genes like me logo Genes that share phenotypes with IL21R: view

Human Phenotype Ontology for IL21R Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL21R Gene

MGI Knock Outs for IL21R:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL21R

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IL21R Gene

Localization for IL21R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL21R Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL21R Gene COMPARTMENTS Subcellular localization image for IL21R gene
Compartment Confidence
plasma membrane 4
cytosol 2
extracellular 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for IL21R Gene

Pathways & Interactions for IL21R Gene

genes like me logo Genes that share pathways with IL21R: view

SIGNOR curated interactions for IL21R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL21R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030101 natural killer cell activation NAS 11081504
genes like me logo Genes that share ontologies with IL21R: view

Drugs & Compounds for IL21R Gene

(1) Drugs for IL21R Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IL21R: view

Transcripts for IL21R Gene

Unigene Clusters for IL21R Gene

Interleukin 21 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL21R Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - -
SP7: -

Relevant External Links for IL21R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL21R Gene

mRNA expression in normal human tissues for IL21R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL21R Gene

This gene is overexpressed in Whole Blood (x5.8).

SOURCE GeneReport for Unigene cluster for IL21R Gene Hs.210546

mRNA Expression by UniProt/SwissProt for IL21R Gene

Tissue specificity: Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
genes like me logo Genes that share expression patterns with IL21R: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL21R Gene

Orthologs for IL21R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL21R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL21R 35
  • 76.8 (n)
  • 65.97 (a)
IL21R 36
  • 65 (a)
(Canis familiaris)
Mammalia IL21R 35
  • 79.82 (n)
  • 72.56 (a)
IL21R 36
  • 71 (a)
(Mus musculus)
Mammalia Il21r 35
  • 73.52 (n)
  • 64.76 (a)
Il21r 16
Il21r 36
  • 64 (a)
(Pan troglodytes)
Mammalia IL21R 35
  • 98.99 (n)
  • 98.75 (a)
IL21R 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Il21r 35
  • 73.78 (n)
  • 65.58 (a)
(Monodelphis domestica)
Mammalia IL21R 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia IL21R 36
  • 36 (a)
(Gallus gallus)
Aves IL21R 35
  • 50.88 (n)
  • 38.53 (a)
IL21R 36
  • 29 (a)
(Anolis carolinensis)
Reptilia IL21R 36
  • 28 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il21r 35
  • 44.49 (n)
  • 34.09 (a)
(Danio rerio)
Actinopterygii il21r 35
  • 40.87 (n)
  • 29.64 (a)
il21r 36
  • 23 (a)
il21rl 36
  • 32 (a)
Species with no ortholog for IL21R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL21R Gene

Gene Tree for IL21R (if available)
Gene Tree for IL21R (if available)

Paralogs for IL21R Gene

No data available for Paralogs for IL21R Gene

Variants for IL21R Gene

Sequence variations from dbSNP and Humsavar for IL21R Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3093370 - 27,444,605(+) AGTTC(C/T)GCAAA reference, missense
VAR_014361 -
VAR_014362 -
VAR_069899 IL21R immunodeficiency (IL21RID)
rs4140673 -- 27,404,311(+) AGCAA(G/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL21R Gene

Variant ID Type Subtype PubMed ID
nsv833179 CNV Loss 17160897
nsv1773 CNV Insertion 18451855
esv2663164 CNV Deletion 23128226

Variation tolerance for IL21R Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL21R Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL21R Gene

Disorders for IL21R Gene

MalaCards: The human disease database

(6) MalaCards diseases for IL21R Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IL21R in MalaCards View complete list of genes associated with diseases


  • IL21R immunodeficiency (IL21RID) [MIM:615207]: An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. {ECO:0000269 PubMed:23440042}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;16)(q27;p11), with BCL6.

Relevant External Links for IL21R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL21R: view

No data available for Genatlas for IL21R Gene

Publications for IL21R Gene

  1. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. (PMID: 11081504) Parrish-Novak J. … Foster D. (Nature 2000) 2 3 4 67
  2. IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. (PMID: 19874204) Guo Y. … Deng H.W. (J. Bone Miner. Res. 2010) 3 23
  3. Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2. (PMID: 20059963) Nara H. … Asao H. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells. (PMID: 20193734) de Totero D. … Ferrini S. (Exp. Hematol. 2010) 3 23
  5. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. (PMID: 19075398) Jin H. … Geha R.S. (J. Clin. Invest. 2009) 3 23

Products for IL21R Gene

Sources for IL21R Gene