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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL21R Gene

protein-coding   GIFtS: 60
GCID: GC16P027413

interleukin 21 receptor

 Explore 29 diseases affiliated with
IL21R via our new
 Human Malady Compendium 
Biological research products
for IL21R
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 21 Receptor1 2     NILR2 3
CD3601 2     IL-21 Receptor2 3
Novel Interleukin Receptor2 3     Interleukin-21 Receptor2
IL-21R2 3     CD360 Antigen3

External Ids:    HGNC: 60061   Entrez Gene: 506152   Ensembl: ENSG000001035227   OMIM: 6053835   UniProtKB: Q9HBE53   

Export aliases for IL21R gene to outside databases

Previous GC identifers: GC16P026842 GC16P027512 GC16P027341 GC16P027380 GC16P027321 GC16P025501


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL21R:
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine
receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit
also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal
of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK)
cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules,
including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in
regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. (provided
by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: IL21R_HUMAN, Q9HBE5
Function: This is a receptor for interleukin-21

Gene Wiki entry for IL21R (Interleukin-21 receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL21R gene promoter:
         Sp1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL21R promoter sequence
   Search SABiosciences Chromatin IP Primers for IL21R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL21R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p11

IL21R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL21R gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P027413:  view genomic region     (about GC identifiers)

Start:
27,413,483 bp from pter      End:
27,463,363 bp from pter
Size:
49,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL21R_HUMAN, Q9HBE5 (See protein sequence)
Recommended Name: Interleukin-21 receptor precursor  
Size: 538 amino acids; 59130 Da
Subunit: Heterodimer with the common gamma subunit. Associates with JAK1
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for IL21R:
3TGX (3D)    
Secondary accessions: A8K9E8 D3DWF7 Q96HZ1 Q9HB91

Explore the universe of human proteins at neXtProt for IL21R: NX_Q9HBE5

Post-translational modifications:

  • C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and
  • bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame1
  • View neXtProt modification sites for NX_Q9HBE5

  • IL21R Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_068570.1  NP_851564.1  NP_851565.4  

    ENSEMBL proteins: 
     ENSP00000338010   ENSP00000456707   ENSP00000379103   ENSP00000379104  

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    Novus Biologicals IL21R Proteins
    Novus Biologicals IL21R Lysates
    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for IL21R

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS11081504


    IL21R for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL21R for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003531 Hempt_rcpt_S_F1_CS

    Graphical View of Domain Structure for InterPro Entry Q9HBE5

    ProtoNet protein and cluster: Q9HBE5

    1 Blocks protein family: IPB003531 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: IL21R_HUMAN, Q9HBE5
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily
    Similarity: Contains 2 fibronectin type-III domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: IL21R_HUMAN, Q9HBE5
    Function: This is a receptor for interleukin-21

    miRNA
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    hsa-miR-140-3p hsa-miR-875-3p hsa-miR-4254 hsa-miR-130a* hsa-miR-23c hsa-miR-548aa hsa-miR-570 hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidIL21R 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL21R

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001532interleukin-21 receptor activity NAS11081504
    GO:0004896cytokine receptor activity ----


    IL21R for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for IL21R: Il21rtm1Wjl Il21rtm1Lex Il21rtm1Day Il21rtm1Kopf
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Il21r):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    IL21R for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Th17 Differentiation
    Th17 Differentiation1.00
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    2IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types1.00
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway1.00
    4IL-9 Signaling Pathways
    IL-21 Signaling Pathways0.90
    5Mucin expression in CF via IL-6, IL-17 signaling pathways
    Cytokine production by Th17 cells in CF (Mouse model)0.37

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 R&D Systems Pathways for IL21R
        IL-21 Signaling Pathways
    IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation


    1 GeneGo (Thomson Reuters) Pathway for IL21R
        Cytokine production by Th17 cells in CF (Mouse model)


    2         Kegg Pathways  (Kegg details for IL21R):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IL21R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL21R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for IL21R (Q9HBE53 ENSP000003380104) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL21Q9HBE43, ENSP000002644974I2D: score=2 STRING: ENSP00000264497
    IL2P605683, ENSP000002267304I2D: score=1 STRING: ENSP00000226730
    JAK1P234583, ENSP000003432044I2D: score=3 STRING: ENSP00000343204
    CBLENSP000002640334STRING: ENSP00000264033
    CBLBENSP000002641224STRING: ENSP00000264122
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019221cytokine-mediated signaling pathway ----
    GO:0030101natural killer cell activation NAS11081504
    GO:0038114interleukin-21-mediated signaling pathway NAS11081504


    IL21R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL21R
    Search CenterWatch for drugs/clinical trials and news about IL21R 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL21R gene (3 alternative transcripts): 
    NM_021798.3  NM_181078.2  NM_181079.4  

    Unigene Cluster for IL21R:

    Interleukin 21 receptor
    Hs.210546  [show with all ESTs]
    Unigene Representative Sequence: NM_181079
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337929(uc002dor.2 uc002doq.2) ENST00000564089 ENST00000395754
    ENST00000561953 ENST00000564583 ENST00000395755(uc002dos.2)

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    hsa-miR-140-3p hsa-miR-875-3p hsa-miR-4254 hsa-miR-130a* hsa-miR-23c hsa-miR-548aa hsa-miR-570 hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidIL21R 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF254067.1 AF269133.1 AK292663.1 AK312825.1 AY358826.1 BC004348.1 BC007946.2 

    7 DOTS entries:

    DT.427597  DT.91698043  DT.100778313  DT.40297197  DT.40126445  DT.438858  DT.100690154 

    24/50 AceView cDNA sequences (see all 50):

    BC007946 NM_021798 BX280799 AF254067 AW576566 NM_181079 BQ018238 BE269215 
    AA689310 BC004348 NM_181078 AW629191 AY358826 BX342766 AW469887 AW504569 
    BX328315 BQ215949 AA873230 CA433219 AI797622 AA897200 AF269133 BF797852 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IL21R (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                              -           -                                       
    SP2:                    -     -     -     -                       -           -                                       
    SP3:                                      -                       -           -                                       
    SP4:                    -     -     -     -                       -           -                                       
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for IL21R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL21R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See IL21R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL21R

    SOURCE GeneReport for Unigene cluster: Hs.210546

    UniProtKB/Swiss-Prot: IL21R_HUMAN, Q9HBE5
    Tissue specificity: Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL21R: 
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              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL21R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL21R gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il21r1 , 5 interleukin 21 receptor1, 5 73.4(n)1
    64.76(a)1
      7 (68.98 cM)5
    605041  NM_021887.21  NP_068687.11 
     1256034295 
    chicken
    (Gallus gallus)
    Aves IL21R1 interleukin 21 receptor 51.32(n)
    39.31(a)
      416586  NM_001030640.1  NP_001025811.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL21R6
    --
    27(a)
    1 ↔ 1
    GL343612.1(190696-201302)
    zebrafish
    (Danio rerio)
    Actinopterygii il21r1 interleukin 21 receptor 41.24(n)
    29.27(a)
      100134976  NM_001113510.1  NP_001106982.1 


    ENSEMBL Gene Tree for IL21R (if available)
    TreeFam Gene Tree for IL21R (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1018 NCBI SNPs in IL21R are shown (see all 1018    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774741001,2
    --25501287(+) GCTAGG/TTGCCC 2 -- us2k10--------
    rs21895221,2
    C,F,--25501750(-) GCCATC/TGGGGT 2 -- us2k15Minor allele frequency- T:0.05NA CSA WA 244
    rs38262541,2
    C,F,H,--25502090(-) ACCAGG/TCGGCC 2 -- ut5113Minor allele frequency- T:0.02EA NS WA 3306
    rs9619141,2
    C,A,--25502270(+) CACCCC/TCACGC 2 -- ut51 ese33Minor allele frequency- T:0.13MN NA 306
    rs758663351,2
    F,--25502738(+) TGGGAC/ACCATT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1156835681,2
    C,F,--25502861(+) TCCCTC/TGGTGA 2 -- int1 ut511Minor allele frequency- T:0.04WA 118
    rs1142265091,2
    C,F,--25502944(+) AAGCAC/TGGGGA 3 H syn1 int11Minor allele frequency- T:0.03WA 118
    rs798540101,2
    C,F,--25502956(+) CGGGTC/TGGATG 3 V syn1 int11Minor allele frequency- T:0.07WA 118
    rs64980221,2
    C,F,A,--25503260(+) aacccG/Cgccac 2 -- int11Minor allele frequency- C:0.07NA 120
    rs770701031,2
    F,--25503355(+) ACCAAG/AGTACC 2 -- int11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for IL21R (27413483 - 27463363 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IL21R
         1 CNV: 35372
    Human Gene Mutation Database (HGMD): IL21R

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL21R for disorders           About GeneDecksing

    OMIM gene information: 605383   
    OMIM disorders: 147050  
    20/29 diseases for IL21R (see all 29):    About MalaCards
    interleukin receptor    ige, elevated level of    gamma chain deficiency    diffuse large b-cell lymphoma
    human t-cell leukemia virus type 1    b-cell lymphomas    common variable immunodeficiency    anaplastic large cell lymphoma
    inflammatory bowel disease    severe combined immunodeficiency    lupus erythematosus    combined immunodeficiency
    systemic lupus erythematosus    rheumatoid arthritis    chronic lymphocytic leukemia    lymphocytic leukemia
    follicular lymphoma    cblc    t-cell leukemia    multiple sclerosis

    1 disease from the University of Copenhagen DISEASES database for IL21R:
    Spinal cord ischemia

    8 Novoseek disease relationships for IL21R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 42.9 5 16142394 (2), 19644854 (2), 19774453 (1)
    inflammatory bowel diseases 22 1 19322899 (1)
    rheumatoid arthritis 15.9 4 15146416 (2), 17032244 (1), 17393408 (1)
    genetic susceptibility 15.1 1 17462506 (1)
    necrosis 9.77 1 11986233 (1)
    osteoarthritis 3.78 1 15146416 (1)
    inflammation 0 1 17241869 (1)
    tumors 0 2 11986233 (1), 19608866 (1)

    Genetic Association Database (GAD): IL21R
    Human Genome Epidemiology (HuGE) Navigator: IL21R (12 documents)

    Export disorders for IL21R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL21R gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with IL21R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. (PubMed id 11081504)1, 2, 3 Parrish-Novak J.... Foster D. (2000)
    2. Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females. (PubMed id 12700598)1, 4, 9 Hecker M....Hackstein H. (2003)
    3. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. (PubMed id 11016959)1, 2, 9 Ozaki K.... Leonard W.J. (2000)
    4. Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. (PubMed id 22235133)1, 2 Hamming O.J.... Hartmann R. (2012)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. (PubMed id 15146416)1, 9 Jungel A....Distler O. (2004)
    9. Heterogeneous expression and function of IL-21R and s usceptibility to IL-21-mediated apoptosis in follicular lymphoma cells. (PubMed id 20193734)1, 9 de Totero D....Ferrini S. (2010)
    10. Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. (PubMed id 15751077)1, 9 Distler J.H....Distler O. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50615 HGNC: 6006 AceView: IL21R Ensembl:ENSG00000103522 euGenes: HUgn50615
    ECgene: IL21R Kegg: 50615 H-InvDB: IL21R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL21R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL21R Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il21r/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL21R gene:
    Search GeneIP for patents involving IL21R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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