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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL21 Gene

protein-coding   GIFtS: 60
GCID: GC04M123534

Interleukin 21

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 211 2
IL-212 3
Za112 3
interleukin-212
Interleukin-21 Isoform2

External Ids:    HGNC: 60051   Entrez Gene: 590672   Ensembl: ENSG000001386847   OMIM: 6053845   UniProtKB: Q9HBE43   

Export aliases for IL21 gene to outside databases

Previous GC identifers: GC04M124446 GC04M123813 GC04M123926 GC04M123992 GC04M123891 GC04M119260


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL21 Gene:
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The
encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation,
proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and
cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus,
psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms
have been observed for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for IL21 Gene: 
IL21 (interleukin 21) is a protein-coding gene. Diseases associated with IL21 include mikulicz disease, and alk-positive anaplastic large cell lymphoma, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Rho Family GTPases. GO annotations related to this gene include interleukin-2 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4
Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive
immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in
proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of
mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon
gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC)
activation and maturation

Gene Wiki entry for IL21 (Interleukin 21) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL21 gene promoter:
         GR   Pbx1a   GR-beta   HTF   NF-AT   C/EBPalpha   NF-AT2   STAT3   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL21 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26-q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q26-q27

IL21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL21 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M123534:  view genomic region     (about GC identifiers)

Start:
123,533,783 bp from pter      End:
123,542,224 bp from pter
Size:
8,442 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4 (See protein sequence)
Recommended Name: Interleukin-21 precursor  
Size: 155 amino acids; 17923 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAG29348.1; Type=Erroneous initiation; Sequence=AAH66258.1; Type=Erroneous initiation;
Sequence=AAH66259.1; Type=Erroneous initiation; Sequence=AAH66260.1; Type=Erroneous initiation;
Sequence=AAH66261.1; Type=Erroneous initiation; Sequence=AAH66262.1; Type=Erroneous initiation;
Sequence=AAH69124.1; Type=Erroneous initiation; Sequence=AAU88182.1; Type=Erroneous initiation;
Sequence=ABG36529.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for IL21:
2OQP (3D)        3TGX (3D)    
Secondary accessions: A5J0L4
Alternative splicing: 2 isoforms:  Q9HBE4-1   Q9HBE4-2   

Explore the universe of human proteins at neXtProt for IL21: NX_Q9HBE4

Explore proteomics data for IL21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HBE4

  • IL21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL21 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001193935.1  NP_068575.1  

    ENSEMBL proteins: 
     ENSP00000264497  

    Human Recombinant Protein Products for IL21: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL21
    OriGene Protein Over-expression Lysate for IL21
    OriGene MassSpec for IL21 
    OriGene Custom Protein Services for IL21
    GenScript Purified and Recombinant Proteins for IL21
    Novus Biologicals IL21 Proteins
    Novus Biologicals IL21 Lysates
    Sino Biological Recombinant Protein for IL21
    Sino Biological Cell Lysate for IL21 
    ProSpec Recombinant Protein for IL21
    Cloud-Clone Corp. Proteins for IL21 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS11081504

    IL21 for ontologies           About GeneDecksing



    IL21 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL21
    R&D Systems Antibodies for IL21 (IL-21)
    OriGene Antibodies for IL21
    OriGene Custom Antibody Services for IL21
    GenScript Custom Superior Antibodies Services for IL21
    Novus Biologicals IL21 Antibodies
    Abcam antibodies for IL21
    Cloud-Clone Corp. Antibodies for IL21 
    ThermoFisher Antibodies for IL21
    LSBio Antibodies in human, mouse, rat for IL21 

    Assay Products for IL21: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL21
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IL21
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL21 
    Cloud-Clone Corp. CLIAs for IL21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    1 InterPro protein domain:
     IPR003443 Interleukin_15-like

    Graphical View of Domain Structure for InterPro Entry Q9HBE4

    ProtoNet protein and cluster: Q9HBE4

    UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4
    Similarity: Belongs to the IL-15/IL-21 family


    IL21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL21_HUMAN, Q9HBE4
    Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive
    immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in
    proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of
    mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon
    gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC)
    activation and maturation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding TAS15546387
    GO:0005134interleukin-2 receptor binding IPI12504082
         
    IL21 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il21):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  normal 

    IL21 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL21: Il21tm1Lex Il21tm1Llit

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL21 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL21
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL21
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL21
    Sirion Biotech Customized adenovirus for overexpression of IL21

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL21 (see all 6)
    OriGene ORF clones in mouse, rat for IL21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL21 (NM_181078)
    Sino Biological Human cDNA Clone for IL21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL21
    Sirion Biotech Customized lentivirus for stable overexpression of IL21 
                         Customized lentivirus expression plasmids for stable overexpression of IL21 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL21
    Search LifeMap BioReagents cell lines for IL21
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL21 About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    MIF Regulation of Innate Immune Cells0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56
    5Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for IL21
        IL-21 Signaling Pathways
    IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL21 (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 GeneGo (Thomson Reuters) Pathway for IL21
        Cytokine production by Th17 cells in CF (Mouse model)



    3         Kegg Pathways  (Kegg details for IL21):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Inflammatory bowel disease (IBD)


    IL21 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for IL21 (Q9HBE42, 3 ENSP000002644974) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201972 I2D: score=1 STRING: ENSP00000250416
    IL21RQ9HBE53, ENSP000003380104I2D: score=2 STRING: ENSP00000338010
    DGKAP237433, ENSP000003284054I2D: score=1 STRING: ENSP00000328405
    IL2RGP317853I2D: score=1 
    CSF2ENSP000002968714STRING: ENSP00000296871
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002729positive regulation of natural killer cell cytokine production IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction NAS11081504
    GO:0008284positive regulation of cell proliferation IDA17673207
    GO:0030890positive regulation of B cell proliferation IDA17673207

    IL21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL21 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL21

    4 Novoseek inferred chemical compound relationships for IL21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 37 3 16339522 (2), 20023635 (1)
    con a 31.9 2 15107555 (1), 12969638 (1)
    rantes 5.24 1 12470608 (1)
    tyrosine 0 4 16020505 (1), 16391014 (1), 18981102 (1), 12794134 (1)

    Search CenterWatch for drugs/clinical trials and news about IL21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL21 gene (2 alternative transcripts): 
    NM_001207006.2  NM_021803.3  

    Unigene Cluster for IL21:

    Interleukin 21
    Hs.567559  [show with all ESTs]
    Unigene Representative Sequence: CD559458
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000264497(uc003ies.2 uc010int.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL21
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL21
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL21
    Clone
    Products:
         
    OriGene clones in human, mouse for IL21 (see all 6)
    OriGene ORF clones in mouse, rat for IL21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL21 (NM_181078)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL21
    Sirion Biotech Customized lentivirus for stable overexpression of IL21 
                         Customized lentivirus expression plasmids for stable overexpression of IL21 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IL21
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL21
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL21

    Additional mRNA sequence: 

    AF254069.1 BC066258.1 BC066259.1 BC066260.1 BC066261.1 BC066262.1 BC069124.1 DQ645417.1 

    1 DOTS entry:

    DT.91917111 

    17 AceView cDNA sequences:

    BC069124 BC066259 BC066261 CD559455 BC066258 NM_021803 BC066262 AF254069 
    CD559614 BC066260 CD559609 CD559459 CD559612 CD559611 CD559610 CD559613 
    BP369699 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTCTTAT
    IL21 Expression
    About this image


    See IL21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL21

    SOURCE GeneReport for Unigene cluster: Hs.567559

    UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4
    Tissue specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or
    monocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL21 (see all 8): 
              Th17 Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL21 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il211 , 5 interleukin 211, 5 76.94(n)1
    63.01(a)1
      3 (18.36 cM)5
    605051  NM_021782.21  NP_068554.11 
     372227595 
    chicken
    (Gallus gallus)
    Aves IL216
    interleukin 21 precursor
    30(a)
    1 ↔ 1
    4(53097087-53101842)


    ENSEMBL Gene Tree for IL21 (if available)
    TreeFam Gene Tree for IL21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/233 SNPs in IL21 are shown (see all 233)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854221441,2
    --123318776(+) GCTTTC/TATATA 2 -- ds50010--------
    rs1907229661,2
    --123318919(+) TTTTTA/GGTTAA 2 -- ds50010--------
    rs178867061,2
    C,F--123319045(-) TTTCCC/TCATAA 2 -- ds50013Minor allele frequency- T:0.04NS CSA 94
    rs1822315941,2
    --123319115(+) TCCACC/TTGGAA 2 -- ut310--------
    rs178863481,2
    C,F--123319143(-) ATATAG/ATAGTG 2 -- ut315Minor allele frequency- A:0.06NS NA 216
    rs178792981,2
    C,F--123319157(-) TGTTAC/TATACT 2 -- ut31 ese312Minor allele frequency- T:0.05NS NA EU 2175
    rs1171276661,2
    C,F--123319185(+) TTAGAT/GCCTCA 2 -- ut311Minor allele frequency- G:0.02EA 120
    rs361168231,2
    C,F--123319206(-) ACACAC/TGGAAG 3 H ut31 syn12Minor allele frequency- T:0.00NA 4612
    rs2016145801,2
    C--123319248(+) GGAAAT/CAGTAT 2 -- ut31 int11Minor allele frequency- C:0.00EU 1321
    rs2019945961,2
    --123319250(+) AAATAA/GTATAC 2 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for IL21 (123533783 - 123542224 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL21:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv879866CNV Gain21882294


    Human Gene Mutation Database (HGMD): IL21
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL21
    DNA2.0 Custom Variant and Variant Library Synthesis for IL21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605384    OMIM disorders: --

    20/69 diseases for IL21 (see all 69):    About MalaCards
    mikulicz disease    alk-positive anaplastic large cell lymphoma    follicular lymphoma    progressive supranuclear palsy
    visceral leishmaniasis    sclerosing cholangitis    dacryoadenitis    reactive arthritis
    psoriasis    primary sclerosing cholangitis    hypersensitivity reaction type ii disease    alopecia areata
    severe combined immunodeficiency    spondyloarthropathy    cholangitis    tauopathy
    common variable immunodeficiency    wegener's granulomatosis    human t-cell leukemia virus type 1    tick-borne encephalitis


    IL21 for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for IL21 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency, x-linked 66.9 3 14966353 (1), 16138102 (1), 12435740 (1)
    autoimmune diseases 58.3 16 19164519 (3), 18056166 (1), 20079789 (1), 17015709 (1) (see all 10)
    autoimmunity 57.8 6 18390721 (2), 18056166 (1), 17312126 (1), 18467657 (1) (see all 5)
    metastatic melanoma 47.7 6 17575227 (1), 18056166 (1), 19276257 (1), 18286285 (1) (see all 5)
    encephalomyelitis 44.9 2 15728477 (1), 18052963 (1)
    tumors 35.2 78 20445344 (5), 16772043 (5), 17574601 (3), 16785506 (3) (see all 33)
    inflammatory bowel diseases 35.1 9 17241869 (1), 18209077 (1), 17982568 (1)
    melanoma 30.5 9 19501956 (2), 16761934 (2), 16772043 (2), 19561536 (1) (see all 5)
    carcinoma renal cell 28.4 8 18056166 (1), 20445344 (1), 18286285 (1), 16761934 (1) (see all 6)
    severe combined immunodeficiency 28 1 14502230 (1)

    Genetic Association Database (GAD): IL21
    Human Genome Epidemiology (HuGE) Navigator: IL21 (46 documents)

    Export disorders for IL21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL21 gene, integrated from 9 sources (see all 377):
    (articles sorted by number of sources associating them with IL21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. (PubMed id 11081504)1, 2, 3 Parrish-Novak J.... Foster D. (2000)
    2. Cloning and characterization of an isoform of interleukin-21. (PubMed id 17673207)1, 2, 9 Rahman M.... Asao H. (2007)
    3. IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells. (PubMed id 15178704)1, 2, 9 Strengell M.... Matikainen S. (2004)
    4. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. (PubMed id 17720724)1, 4, 9 Sawalha A.H....Harley J.B. (2008)
    5. Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes. (PubMed id 17462506)1, 4, 9 Asano K....Ogihara T. (2007)
    6. Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. (PubMed id 22235133)1, 2 Hamming O.J.... Hartmann R. (2012)
    7. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients . (PubMed id 20881011)1, 4 Webb R....Sawalha A.H. (2011)
    8. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    9. Four novel coeliac disease regions replicated in an a ssociation study of a Swedish-Norwegian family cohort. (PubMed id 19693089)1, 4 Amundsen S.S....Sollid L.M. (2010)
    10. Only one independent genetic association with rheumat oid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome -wide level of significance. (PubMed id 20553587)1, 4 Hollis-Moffatt J.E....Merriman T.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59067 HGNC: 6005 AceView: IL21 Ensembl:ENSG00000138684 euGenes: HUgn59067
    ECgene: IL21 Kegg: 59067 H-InvDB: IL21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL21 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/il21/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL21 gene:
    Search GeneIP for patents involving IL21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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