Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL21 Gene

protein-coding GIFtS: 59
GCID: GC04M123534

interleukin 21

Explore 65 diseases affiliated with
IL21 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 21¹ ²
IL-21¹ ² ³
Za11¹ ² ³
Interleukin-21¹
Interleukin-21 Isoform²

External Ids:	HGNC: 6005¹	Entrez Gene: 59067²	Ensembl: ENSG00000138684⁷	OMIM: 605384⁵	UniProtKB: Q9HBE4³

Export aliases for IL21 gene to outside databases

Previous GC identifers: GC04M124446 GC04M123813 GC04M123926 GC04M123992 GC04M123891 GC04M119260

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL21:

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded

protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation

and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells.

Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic

inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for

this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4

Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity.

Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and

maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in

response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK

cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation

Gene Wiki entry for IL21 (Interleukin 21)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL21 gene promoter:
GR Pbx1a GR-beta HTF NF-AT C/EBPalpha NF-AT2 STAT3 GR-alpha NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL21 promoter sequence

Search SABiosciences Chromatin IP Primers for IL21

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL21

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26-q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q26-q27

IL21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL21 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M123534: view genomic region (about GC identifiers)

Start:	123,533,783 bp from pter	End:	123,542,224 bp from pter
Size:	8,442 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4 (See protein sequence)

Recommended Name: Interleukin-21 precursor

Size: 155 amino acids; 17923 Da

Subcellular location: Secreted

Sequence caution: Sequence=AAG29348.1; Type=Erroneous initiation; Sequence=AAH66258.1; Type=Erroneous initiation;

Sequence=AAH66259.1; Type=Erroneous initiation; Sequence=AAH66260.1; Type=Erroneous initiation; Sequence=AAH66261.1;

Type=Erroneous initiation; Sequence=AAH66262.1; Type=Erroneous initiation; Sequence=AAH69124.1; Type=Erroneous

initiation; Sequence=AAU88182.1; Type=Erroneous initiation; Sequence=ABG36529.1; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for IL21:

2OQP (3D)

3TGX (3D)

Secondary accessions: A5J0L4

Alternative splicing: 2 isoforms: Q9HBE4-1 Q9HBE4-2

Explore the universe of human proteins at neXtProt for IL21: NX_Q9HBE4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBE4

IL21 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001193935.1 NP_068575.1

ENSEMBL proteins:

ENSP00000264497

Human Recombinant Protein Products for IL21:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IL21 OriGene Protein Over-expression Lysate: IL21 OriGene Custom Protein Services for IL21
	GenScript Purified and Recombinant Proteins for IL21
	Novus Biologicals IL21 Proteins Novus Biologicals IL21 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL21
	Uscn Proteins for IL21

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	NAS	11081504

IL21 for ontologies About GeneDecksing

IL21 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL21
	R&D Systems Antibodies for IL21 (IL-21)
	OriGene Antibodies: IL21 OriGene Custom Antibody Services for IL21
	GenScript Custom Superior Antibodies Services for IL21
	Novus Biologicals IL21 Antibodies
	Abcam antibodies for IL21
	Uscn Antibodies for IL21
	ThermoFisher Antibodies for IL21

Assay Products for IL21:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IL21
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL21

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL21 for domains About GeneDecksing

1 InterPro domain/family:

IPR003443 Interleukin_15-like

Graphical View of Domain Structure for InterPro Entry Q9HBE4

ProtoNet protein and cluster: Q9HBE4

UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4

Similarity: Belongs to the IL-15/IL-21 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IL21_HUMAN, Q9HBE4

Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity.

Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and

maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in

response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK

cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005126	cytokine receptor binding	TAS	15546387
GO:0005134	interleukin-2 receptor binding	IPI	12504082

IL21 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il21):

cellular

hematopoietic system

homeostasis/metabolism

immune system

normal

IL21 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for IL21: Il21^tm1Lex Il21^tm1Llit

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL21

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL21
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL21
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL21 (see all 7) OriGene shRNA RFP: IL21 OriGene siRNA: IL21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL21
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL21

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IL21
			Sirion Biotech Customized adenovirus for overexpression of IL21 Sirion Biotech Customized adenovirus for potent knockdown of IL21

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL21 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL21 (NM_181078)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL21

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL21
		Search LifeMap BioReagents cell lines for IL21
		Sirion Biotech Customized stable knockdown cell line services for IL21 Sirion Biotech Customized inducible knockdown cell line services for IL21 Sirion Biotech Customized stable overexpressing cell line services for IL21 Sirion Biotech Customized inducible overexpressing cell line services for IL21

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IL21

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Akt Signaling

Akt Signaling

1.00

p38 Signaling

0.60

Th17 Differentiation

Th17 Differentiation

1.00

IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

4 R&D Systems Pathways for IL21

	IL-21 Signaling Pathways
	IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th17 Differentiation

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL21 (see all 15)

	MIF Regulation of Innate Immune Cells
	STAT3 Pathway
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C

1 GeneGo (Thomson Reuters) Pathway for IL21

Cytokine production by Th17 cells in CF (Mouse model)

2 Kegg Pathways (Kegg details for IL21):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

IL21 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL21

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/15 Interacting proteins for IL21 (Q9HBE4^{2, 3} ENSP00000264497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARP2	Q9UGN5²^,³, ENSP00000250416⁴	MINT-8201972 I2D: score=1 STRING: ENSP00000250416
IL21R	Q9HBE5³, ENSP00000338010⁴	I2D: score=2 STRING: ENSP00000338010
DGKA	P23743³, ENSP00000328405⁴	I2D: score=1 STRING: ENSP00000328405
IL2RG	P31785³	I2D: score=1
CSF2	ENSP00000296871⁴	STRING: ENSP00000296871

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002729	positive regulation of natural killer cell cytokine production	IEA	--
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	NAS	11081504
GO:0008284	positive regulation of cell proliferation	IDA	17673207
GO:0030890	positive regulation of B cell proliferation	IDA	17673207

IL21 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL21 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL21
4 Novoseek chemical compound relationships for IL21 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cytidine	37	3	16339522 (2), 20023635 (1)
con a	31.9	2	15107555 (1), 12969638 (1)
rantes	5.24	1	12470608 (1)
tyrosine	0	4	16020505 (1), 16391014 (1), 18981102 (1), 12794134 (1)

Search CenterWatch for drugs/clinical trials and news about IL21

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL21 gene (2 alternative transcripts):

NM_001207006.2 NM_021803.3

Unigene Cluster for IL21:

Interleukin 21

Hs.567559 [show with all ESTs]

Unigene Representative Sequence: CD559458

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000264497(uc003ies.2 uc010int.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL21
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL21
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL21 (see all 7) OriGene shRNA RFP: IL21 OriGene siRNA: IL21
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL21
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL21

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL21 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): IL21 (NM_181078)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL21

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL21
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL21
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL21

Additional cDNA sequence:

AF254069.1 BC066258.1 BC066259.1 BC066260.1 BC066261.1 BC066262.1 BC069124.1 DQ645417.1

1 DOTS entry:

DT.91917111

17 AceView cDNA sequences:

BC066259 BC069124 CD559455 BC066261 BC066262 BC066258 NM_021803 AF254069

BC066260 CD559609 CD559614 CD559459 CD559611 CD559612 CD559613 CD559610

BP369699

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATTCTTAT

About this image

IL21 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Hepatic Mesenchyme

Mesothelial Cells

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IL21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL21

SOURCE GeneReport for Unigene cluster: Hs.567559

UniProtKB/Swiss-Prot: IL21_HUMAN, Q9HBE4

Tissue specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including IL21 (see all 8):

Th17 Response in human mouse rat

Interferons & Receptors in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Cytokines & Chemokines in human mouse rat

Common Cytokines in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL21 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL21
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL21
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL21

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IL21

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL21 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il21^{1 , 5}	interleukin 21^{1, 5}	76.94(n)¹ 63.01(a)¹		3 (18.36 cM)⁵ 60505¹ NM_021782.2¹ NP_068554.1¹ 37222759⁵
chicken (Gallus gallus)	Aves	Q58IU6_CHICK⁶	interleukin 21	31(a)	1 ↔ 1	4(55218439-55223194)

ENSEMBL Gene Tree for IL21 (if available)
TreeFam Gene Tree for IL21 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185422144^1,2		--	123533453(+)	`GCTTTC/TATATA`	2	--	ds500¹		0	--	--	--	--
rs190722966^1,2		--	123533596(+)	`TTTTTA/GGTTAA`	2	--	ds500¹		0	--	--	--	--
rs17886706^1,2	C,F	--	123533722(-)	`TTTCCC/TCATAA`	2	--	ds500¹		3		NS CSA	94
rs182231594^1,2		--	123533792(+)	`TCCACC/TTGGAA`	2	--	ut3¹		0	--	--	--	--
rs17886348^1,2	C,F	--	123533820(-)	`ATATAG/ATAGTG`	2	--	ut3¹		5		NS NA	216
rs17879298^1,2	C,F	--	123533834(-)	`TGTTAC/TATACT`	2	--	ut3¹ ese³		12		NS NA EU	2175
rs117127666^1,2	C,F	--	123533862(+)	`TTAGAT/GCCTCA`	2	--	ut3¹		1		EA	120
rs36116823^1,2	C,F	--	123533883(-)	`ACACAC/TGGAAG`	3	H	syn¹ ut3¹		2		NA	4612
rs201994596^1,2		--	123533927(+)	`AAATAA/GTATAC`	2	--	int¹ ut3¹		0	--	--	--	--
rs184476156^1,2	C	--	123533942(+)	`AGTAAC/TTAAGA`	2	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL21 (123533783 - 123542224 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL21: --
Human Gene Mutation Database (HGMD): IL21

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL21

DNA2.0 Custom Variant and Variant Library Synthesis for IL21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL21 for disorders           About GeneDecksing

OMIM gene information: 605384    OMIM disorders: --

20/65 diseases for IL21 (see all 65):    About MalaCards

severe combined immunodeficiency psoriasis diffuse large b-cell lymphoma human t-cell leukemia virus type 1

hypersensitivity reaction type ii disease supranuclear palsy progressive supranuclear palsy sclerosing cholangitis

combined immunodeficiency b-cell lymphomas common variable immunodeficiency primary sclerosing cholangitis

anaplastic large cell lymphoma inflammatory bowel disease alopecia areata wegener's granulomatosis

visceral leishmaniasis lupus erythematosus cholangitis rheumatoid arthritis

10/21 Novoseek disease relationships for IL21 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
severe combined immunodeficiency, x-linked	66.9	3	14966353 (1), 16138102 (1), 12435740 (1)
autoimmune diseases	58.3	16	19164519 (3), 18056166 (1), 20079789 (1), 17015709 (1) (see all 10)
autoimmunity	57.8	6	18390721 (2), 18056166 (1), 17312126 (1), 18467657 (1) (see all 5)
metastatic melanoma	47.7	6	17575227 (1), 18056166 (1), 19276257 (1), 18286285 (1) (see all 5)
encephalomyelitis	44.9	2	15728477 (1), 18052963 (1)
tumors	35.2	78	20445344 (5), 16772043 (5), 17574601 (3), 16785506 (3) (see all 33)
inflammatory bowel diseases	35.1	9	17241869 (1), 18209077 (1), 17982568 (1)
melanoma	30.5	9	19501956 (2), 16761934 (2), 16772043 (2), 19561536 (1) (see all 5)
carcinoma renal cell	28.4	8	18056166 (1), 20445344 (1), 18286285 (1), 16761934 (1) (see all 6)
severe combined immunodeficiency	28	1	14502230 (1)

Human Genome Epidemiology (HuGE) Navigator: IL21 (46 documents)

Export disorders for IL21 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL21 gene, integrated from 9 sources (see all 351):
(articles sorted by number of sources associating them with IL21)

Utopia: connect your pdf to the dynamic
world of online information

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. (PubMed id 11081504)^{1, 2, 3} Parrish-Novak J.... Foster D. (2000)
Cloning and characterization of an isoform of interleukin-21. (PubMed id 17673207)^{1, 2, 9} Rahman M.... Asao H. (2007)
IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells. (PubMed id 15178704)^{1, 2, 9} Strengell M.... Matikainen S. (2004)
Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. (PubMed id 22235133)^{1, 2} Hamming O.J.... Hartmann R. (2012)
The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue. (PubMed id 17565991)^{1, 2} Bondensgaard K....Hjorth S.A. (2007)
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. (PubMed id 17947662)^{1, 3} Kuchen S....Ettinger R. (2007)
Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. (PubMed id 15147560)^{1, 2} Sivakumar P.V.... Clegg C.H. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Autocrine regulation of IL-21 production in human T lymphocytes. (PubMed id 18209077)^{1, 9} Caprioli F....Monteleone G. (2008)
Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21. (PubMed id 18829491)^{1, 9} Ansen S....Hirano N. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 59067	HGNC: 6005	AceView: IL21	Ensembl:ENSG00000138684	euGenes: HUgn59067
ECgene: IL21	Kegg: 59067	H-InvDB: IL21

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL21	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL21	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/il21/

Intellectual Property for IL21 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IL21 gene:
Search GeneIP for patents involving IL21

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL21
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for IL21 (IL-21)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for IL21		OriGene shRNA RFP for IL21
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL21		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL21
	OriGene Protein Over-expression Lysate for IL21		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IL21		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL21		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL21
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for IL21		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IL21		OriGene Custom Protein Services for IL21
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL21
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL21
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL21
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL21
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL21
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL21

	GenScript Purified and Recombinant Proteins for IL21		GenScript cDNA clones with any tag delivered in your preferred vector for IL21
	GenScript Custom Assay Services for IL21		GenScript Custom Superior Antibodies Services for IL21
	GenScript Custom overexpressing Cell Line Services for IL21		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in IL21 promoter
	Search Chromatin IP Primers for IL21
	RT² qPCR Primer Assay in human, mouse, rat IL21
	GNC Network for IL21
	SABiosciences PCR Arrays including human, mouse, rat IL21

Search Tocris compounds for IL21

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IL21 antibodies
	IL21 proteins
	IL21 lysates

	Antibodies for IL21
	See all of Abcam's Antibodies, Kits and Proteins for IL21
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for IL21

IL21 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IL21

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IL21

	Browse SwitchGear 3'UTR luciferase reporter plasmids for IL21
	SwitchGear Promoter luciferase reporter plasmids for IL21

ThermoFisher Antibodies for IL21

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL21

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL21

Sirion Biotech Customized:

	stable knockdown cell line services for IL21
	inducible knockdown cell line services for IL21
	design and validation of potent shRNA sequences against IL21
	adenovirus for potent knockdown of IL21
	adenovirus for overexpression of IL21
	stable overexpressing cell line services for IL21
	inducible overexpressing cell line services for IL21

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IL21 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

IL21 Gene

interleukin 21

Aliases
for IL21 gene

Summaries
for IL21 gene

Genomic Views
for IL21 gene

Proteins
for IL21 gene

Protein Domains /
Families
for IL21 gene

Function
for IL21 gene

Pathways & Interactions
for IL21 gene

Drugs & Compounds
for IL21 gene

Transcripts
for IL21 gene

Expression
for IL21 gene

Orthologs
for IL21 gene

Paralogs
for IL21 gene

Genomic Variants
for IL21 gene

Disorders / Diseases
for IL21 gene

Publications
for IL21 gene

External Searches for IL21 gene

Genome Databases showing IL21 gene

Other Databases showing IL21 gene

Specialized Databases showing IL21 gene

Intellectual Property
for IL21 gene

Products
for IL21 gene

View Random Gene

Lymphoma
Autoimmune Diseases
Encephalomyelitis
Melanoma
Inflammation
Colitis Ulcerative
Osteoarthritis
immunodeficiency
allergy
Rheumatoid Arthritis
Severe Combined Immunodeficiency
Tumors
Autoimmunity
SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED
Necrosis
metastatic melanoma
Cancer
Carcinoma Renal Cell
Lymphoma T-Cell Cutaneous
Lupus Erythematosus Systemic
Inflammatory Bowel Diseases

Advanced Search

Export list of displayed genes

IL21 Gene

interleukin 21

Aliasesfor IL21 gene

Summariesfor IL21 gene

Genomic Viewsfor IL21 gene

Proteinsfor IL21 gene

Protein Domains /Familiesfor IL21 gene

Functionfor IL21 gene

Pathways & Interactionsfor IL21 gene

Drugs & Compoundsfor IL21 gene

Transcriptsfor IL21 gene

Expression for IL21 gene

Orthologsfor IL21 gene

Paralogsfor IL21 gene

Genomic Variantsfor IL21 gene

Disorders / Diseasesfor IL21 gene

Publicationsfor IL21 gene

External Searches for IL21 gene

Genome Databases showing IL21 gene

Other Databases showing IL21 gene

Specialized Databases showing IL21 gene

Intellectual Propertyfor IL21 gene

Productsfor IL21 gene

View Random Gene

Aliases
for IL21 gene

Summaries
for IL21 gene

Genomic Views
for IL21 gene

Proteins
for IL21 gene

Protein Domains /
Families
for IL21 gene

Function
for IL21 gene

Pathways & Interactions
for IL21 gene

Drugs & Compounds
for IL21 gene

Transcripts
for IL21 gene

Expression
for IL21 gene

Orthologs
for IL21 gene

Paralogs
for IL21 gene

Genomic Variants
for IL21 gene

Disorders / Diseases
for IL21 gene

Publications
for IL21 gene

Intellectual Property
for IL21 gene

Products
for IL21 gene