IL20RB Gene
protein-coding GIFtS: 50
GCID: GC03P136665
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|
interleukin 20 receptor beta(Previous name: fibronectin type III domain containing 6 )
(Previous symbol: FNDC6)
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Aliases
for IL20RB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 20 Receptor Beta1 2 | | IL-20RB2 3 | | DIRS11 2 3 | | IL-20 Receptor Subunit Beta2 3 | | IL-20R21 2 3 | | MGC349231 | | FNDC61 2 | | Interleukin-20 Receptor II2 | | Fibronectin Type III Domain Containing 61 2 | | Interleukin-20 Receptor Subunit Beta2 | | IL-20R-Beta1 | | |
Export aliases for IL20RB gene to outside databasesPrevious GC identifers: GC00U990739 GC03P138161 GC03P134052 |
Summaries
for IL20RB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL20RB:
IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al.,2001 (PubMed 11163236)).(supplied by OMIM, Feb 2009)
UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0Function: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor forIL20 and IL24
Gene Wiki entry for IL20RB (Interleukin 20 receptor, beta subunit)
|
Genomic Views
for IL20RB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL20RB gene promoter:
AhR AML1a Pax-2 Pax-2a Arnt Meis-1b YY1 CP2 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL20RB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL20RB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q22.3 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q22.3IL20RB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P136665: view genomic region
(about GC identifiers)
Start:
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136,665,072 bp from pter |
End:
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136,729,927 bp from pter |
Size:
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64,856 bases |
Orientation:
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plus strand |
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Proteins
for IL20RB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0 (See
protein sequence)Recommended Name: Interleukin-20 receptor subunit beta precursor Size: 311 amino acids; 35076 Da
Subunit: Heterodimer with IL20RA and heterodimer with IL22RA1
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
1 PDB 3D structure from  and Proteopedia  for IL20RB:4DOH (3D)
Secondary accessions: B4DL40 Q6P438 Q8TAJ7Explore the universe of human proteins at neXtProt for IL20RB: NX_Q6UXL0
IL20RB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653318.2
ENSEMBL proteins: ENSP00000328133 ENSP00000418637 ENSP00000417437 ENSP00000420725 ENSP00000311979
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
IL20RB for ontologies About GeneDecksing
IL20RB Antibody Products:
Assay Products for IL20RB: |
Protein
Domains /
Families
for IL20RB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL20RB for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXL0ProtoNet protein and cluster: Q6UXL0 UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0Similarity: Belongs to the type II cytokine receptor familySimilarity: Contains 2 fibronectin type-III domains |
Function
for IL20RB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0Function: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor forIL20 and IL24
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL20RB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL20RB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20RB |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
IL20RB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IL20RB:
Animal Models:
Mouse knock-out Il20rbtm1Uwe for IL20RB
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Il20rb):
IL20RB for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL20RB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Jak-STAT signaling pathway | | | 2 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for IL20RB):
IL20RB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL20RB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/20 Interacting proteins for IL20RB (Q6UXL03 ENSP000003281334) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001808 | negative regulation of type IV hypersensitivity |
IEA | -- | | GO:0002437 | inflammatory response to antigenic stimulus |
IEA | -- | | GO:0002765 | immune response-inhibiting signal transduction |
IEA | -- | | GO:0032689 | negative regulation of interferon-gamma production |
IEA | -- | | GO:0032703 | negative regulation of interleukin-2 production |
IEA | -- |
IL20RB for ontologies About GeneDecksing
|
Drugs & Compounds
for IL20RB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IL20RB
Search CenterWatch for drugs/clinical trials and news about IL20RB / I20RB
|
Transcripts
for IL20RB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL20RB gene: NM_144717.3 Unigene Cluster for IL20RB: Interleukin 20 receptor beta Hs.61232 [show with all ESTs]Unigene Representative Sequence: NM_1447176 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000484501 ENST00000329582(uc003eri.2 uc003erj.2) ENST00000469964
ENST00000491483 ENST00000475972(uc010hud.2) ENST00000309741
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL20RB (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL20RB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IL20RB (NM_144717) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL20RB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20RB |
Additional cDNA sequence: AJ431617.1 AK296832.1 AK316084.1 AY358305.1 BC027449.1 BC063696.1 5 DOTS entries: DT.101977165 DT.410873 DT.100021077 DT.99997292 DT.95321065
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for IL20RB About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | | |
ECgene alternative splicing isoforms for IL20RB
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Expression
for IL20RB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL20RB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTTGTGC
About this image
See IL20RB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL20RB
SOURCE GeneReport for Unigene cluster: Hs.61232
UniProtKB/Swiss-Prot: I20RB_HUMAN, Q6UXL0Tissue specificity: Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin
SABiosciences Expression via Pathway-Focused PCR Array including IL20RB: | Interferons & Receptors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL20RB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL20RB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL20RB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL20RB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20RB |
Orthologs
for IL20RB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL20RB gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for IL20RB (if available)
TreeFam Gene Tree for IL20RB (if available) |
Paralogs
for IL20RB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL20RB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL20RB (136665072 - 136729927 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL20RB: --
Human Gene Mutation Database (HGMD): IL20RB
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL20RB |
|
Disorders
/ Diseases
for IL20RB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL20RB for disorders About GeneDecksing
OMIM gene information: 605621
OMIM disorders: --
4  diseases for IL20RB: About MalaCardscblc liver cancer psoriasis hypoxia
1 disease from the University of Copenhagen DISEASES database for IL20RB:Psoriasis Human Genome Epidemiology (HuGE) Navigator: IL20RB (1 document)
Export disorders for IL20RB gene to outside databases
|
Publications
for IL20RB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL20RB gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with IL20RB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interleukin 20: discovery, receptor identification, and role in epidermal function. (PubMed id 11163236)1, 2, 3 Blumberg H.... Chandrasekher Y.A. (2001)
- IL-20: biological functions and clinical implications . (PubMed id 16703417)1, 3 Wei C.C....Chang M.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. (PubMed id 14580208)1, 2 Pletnev S.... Zdanov A. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. (PubMed id 12351624)1, 2 Parrish-Novak J.... Chandrasekher Y.A. (2002)
- STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. (PubMed id 11564763)1, 2 Dumoutier L.... Renauld J.-C. (2001)
- Purification, crystallization and preliminary X-ray di ffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. (PubMed id 22232181)1 Logsdon N.J....Walter M.R. (2012)
- Structural basis for receptor sharing and activation b y interleukin-20 receptor-2 (IL-20R2) binding cytokines. (PubMed id 22802649)1 Logsdon N.J....Walter M.R. (2012)
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External Searches for IL20RB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL20RB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL20RB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL20RB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL20RB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IL20RB gene:
Search GeneIP for patents involving IL20RB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL20RB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL20RB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL20RB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL20RB | | | OriGene Protein Over-expression Lysate for IL20RB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL20RB | | OriGene 3'-UTR Clone for IL20RB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL20RB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL20RB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL20RB | | OriGene Custom Protein Services for IL20RB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL20RB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL20RB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL20RB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL20RB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL20RB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL20RB |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20RB |
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