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IL20RA Gene

protein-coding   GIFtS: 61
GCID: GC06M137321

Interleukin 20 Receptor, Alpha

  See IL20RA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 20 Receptor, Alpha1 2     Class II Cytokine Receptor ZCYTOR72
Cytokine Receptor Family 2 Member 82 3     Interleukin-20 Receptor I2
CRF2-82 3     Interleukin-20 Receptor Subunit Alpha2
IL-20R-alpha2 3     ZcytoR73
IL-20R12 3     Cytokine Receptor Class-II Member 83
IL-20RA2 3     IL-20 Receptor Subunit Alpha3

External Ids:    HGNC: 60031   Entrez Gene: 538322   Ensembl: ENSG000000164027   OMIM: 6056205   UniProtKB: Q9UHF43   

Export aliases for IL20RA gene to outside databases

Previous GC identifers: GC06M136944 GC06M137168 GC06M137301 GC06M137362 GC06M134884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL20RA Gene:
This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the
receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor
is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and
interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for IL20RA Gene:
IL20RA (interleukin 20 receptor, alpha) is a protein-coding gene. Diseases associated with IL20RA include psoriasis. GO annotations related to this gene include interleukin-20 binding. An important paralog of this gene is IL22RA2.

UniProtKB/Swiss-Prot: I20RA_HUMAN, Q9UHF4
Function: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for
IL26

Gene Wiki entry for IL20RA (Interleukin 20 receptor, alpha subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL20RA gene promoter:
         AREB6   STAT1   POU2F1   POU2F1a   STAT1beta   Cart-1   STAT3   Nkx2-5   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL20RA promoter sequence
   Search Chromatin IP Primers for IL20RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL20RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.3   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q23.3

IL20RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL20RA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M137321:  view genomic region     (about GC identifiers)

Start:
137,321,108 bp from pter      End:
137,366,298 bp from pter
Size:
45,191 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: I20RA_HUMAN, Q9UHF4 (See protein sequence)
Recommended Name: Interleukin-20 receptor subunit alpha precursor  
Size: 553 amino acids; 62485 Da
Subunit: Heterodimer with IL20RB and heterodimer with IL10RB
1 PDB 3D structure from and Proteopedia for IL20RA:
4DOH (3D)    
Secondary accessions: Q14CW2 Q6UWA9 Q96SH8
Alternative splicing: 2 isoforms:  Q9UHF4-1   Q9UHF4-2   

Explore the universe of human proteins at neXtProt for IL20RA: NX_Q9UHF4

Explore proteomics data for IL20RA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn83, Asn91, Asn182, Asn191, Asn200

  • See IL20RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265651.1  NP_001265652.1  NP_001265653.1  NP_055247.3  

    ENSEMBL proteins: 
     ENSP00000314976   ENSP00000356720   ENSP00000437843   ENSP00000356722  

    IL20RA Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IL20RA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL20RA
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    Novus Biologicals IL20RA Protein
    Novus Biologicals IL20RA Lysate
    Sino Biological Recombinant Protein for IL20RA
    Sino Biological Cell Lysate for IL20RA
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IL20RA 

     
    antibodies-online proteins for IL20RA (7 products) 

     
    antibodies-online peptides for IL20RA

    IL20RA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL20RA
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    Abcam antibodies for IL20RA
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    antibodies-online antibodies for IL20RA (40 products) 

    IL20RA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    antibodies-online kits for IL20RA (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 20 receptor, alpha subunit
    IL-10 receptor family

    4 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold
     IPR015713 IL-20_rcpt_alpha

    Graphical View of Domain Structure for InterPro Entry Q9UHF4

    ProtoNet protein and cluster: Q9UHF4

    1 Blocks protein domain: IPB001187 Tissue factor

    UniProtKB/Swiss-Prot: I20RA_HUMAN, Q9UHF4
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 2 fibronectin type-III domains


    Find genes that share domains with IL20RA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I20RA_HUMAN, Q9UHF4
    Function: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for
    IL26

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042015interleukin-20 binding IEA--
         
    Find genes that share ontologies with IL20RA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL20RA:
     Increased cell number in G1, s 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il20ra):
     cellular  hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with IL20RA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il20ratm1.1Misc for IL20RA

       genOway: Develop your customized and physiologically relevant rodent model for IL20RA

    miRNA
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    miRTarBase miRNAs that target IL20RA:
    hsa-mir-26b-5p (MIRT029093)

    Block miRNA regulation of human, mouse, rat IL20RA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL20RA (see all 13):
    hsa-miR-3163 hsa-miR-550a hsa-miR-4288 hsa-miR-589* hsa-miR-632 hsa-miR-346 hsa-miR-944 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidIL20RA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IL20RA
    Predesigned siRNA for gene silencing in human, mouse, rat IL20RA

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: IL20RA (NM_014432)
    Sino Biological Human cDNA Clone for IL20RA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20RA

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20RA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I20RA_HUMAN, Q9UHF4: Membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL20RA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL20RA About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    3TGF-Beta Pathway
    MAPK Family Pathway0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with IL20RA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    7 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL20RA (see first 5)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling
    Tec Kinases Signaling
    MAPK Family Pathway



    2 Kegg Pathways  (Kegg details for IL20RA):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL20RA: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL20RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for IL20RA (Q9UHF43 ENSP000003149764) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL19Q9UHD03, ENSP000003430004I2D: score=1 STRING: ENSP00000343000
    IL20Q9NYY13, ENSP000003560634I2D: score=1 STRING: ENSP00000356063
    IL24Q130073, ENSP000002949844I2D: score=1 STRING: ENSP00000294984
    IL26Q9NPH93I2D: score=1 
    MLH1P406923I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019221cytokine-mediated signaling pathway IEA--
    GO:0045124regulation of bone resorption IEA--
    GO:2001244positive regulation of intrinsic apoptotic signaling pathway IEA--

    Find genes that share ontologies with IL20RA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL20RA (I20RA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL20RA gene (4 alternative transcripts): 
    NM_001278722.1  NM_001278723.1  NM_001278724.1  NM_014432.3  

    Unigene Cluster for IL20RA:

    Interleukin 20 receptor, alpha
    Hs.445868  [show with all ESTs]
    Unigene Representative Sequence: NM_014432
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316649(uc003qhi.3 uc011edl.2) ENST00000468393 ENST00000367746
    ENST00000461799 ENST00000460306 ENST00000541547 ENST00000367748(uc003qhj.3 uc003qhk.3 uc010kgy.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat IL20RA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL20RA (see all 13):
    hsa-miR-3163 hsa-miR-550a hsa-miR-4288 hsa-miR-589* hsa-miR-632 hsa-miR-346 hsa-miR-944 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidIL20RA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL20RA
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    GenScript: all cDNA clones in your preferred vector: IL20RA (NM_014432)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20RA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL20RA
      QuantiTect SYBR Green Assays in human, mouse, rat IL20RA
      QuantiFast Probe-based Assays in human, mouse, rat IL20RA

    Additional mRNA sequence: 

    AF184971.1 AJ420490.1 AK098312.1 AK297121.1 AK307072.1 AK315293.1 AY358883.1 BC113574.1 
    BC113602.1 

    6 DOTS entries:

    DT.212820  DT.100748883  DT.99935447  DT.95357173  DT.91967433  DT.97808767 

    Selected AceView cDNA sequences (see all 66):

    AI381033 CB128408 AI350971 NM_014432 BM674665 AA514541 BQ185521 BU579846 
    AI308941 AA583432 AA299011 AY358883 AI912054 BM683620 AA632915 CK299400 
    BM970319 CA454197 AI675877 BG743223 BU580093 BQ187458 BG741175 AW340967 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL20RA (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
    SP1:                          -     -     -     -     -                             -     -                                       
    SP2:                          -     -     -     -     -           -                 -     -                                       
    SP3:                          -     -     -     -     -                                                                           
    SP4:                                      -     -     -           -     -           -     -                                       
    SP5:                          -     -                                                                                             


    ECgene alternative splicing isoforms for IL20RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL20RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGTCTCTT
    IL20RA Expression
    About this image


    IL20RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
    IL20RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL20RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445868

    UniProtKB/Swiss-Prot: I20RA_HUMAN, Q9UHF4
    Tissue specificity: Widely expressed with highest levels in skin and testis and high levels in brain. Highly
    expressed in psoriatic skin

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL20RA: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL20RA
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    QuantiFast Probe-based Assays in human, mouse, rat IL20RA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL20RA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il20ra1 , 5 interleukin 20 receptor, alpha1, 5 74.47(n)1
    64.99(a)1
      10 (8.76 cM)5
    2373131  NM_172786.21  NP_766374.11 
     197125875 
    chicken
    (Gallus gallus)
    Aves IL20RA1 interleukin 20 receptor, alpha 55.49(n)
    43.47(a)
      421686  XM_419723.4  XP_419723.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crfb81 cytokine receptor family member b8 45.25(n)
    34.49(a)
      556728  NM_001079676.2  NP_001073144.2 


    ENSEMBL Gene Tree for IL20RA (if available)
    TreeFam Gene Tree for IL20RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL20RA gene
    IL22RA22  IL22RA12  

    Find genes that share paralogs with IL20RA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL20RA (see all 1064)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384243181,2
    C,Funtested1137323071(+) ATGTTC/TCTTGT 2 E G mis12Minor allele frequency- T:0.00NA EU 5871
    rs3725495211,2
    C--137320660(+) AGAATA/GTCAAT 1 -- ds50010--------
    rs1409450881,2
    --137320703(+) TAAAAC/GCAACT 1 -- ds50010--------
    rs1831276921,2
    C--137320723(+) ATTCCC/TCTTTT 1 -- ds50010--------
    rs9274431,2
    C,F,O,A,H--137320867(+) TATGTT/CTAAAT 1 -- ds500125Minor allele frequency- C:0.27MN NS EA NA WA CSA 2344
    rs1868770401,2
    --137320973(+) TAAGTA/GCCTTC 1 -- ds50010--------
    rs9274441,2
    C,F,A,H--137320996(+) CTTTTT/AATCCT 1 -- ds500113Minor allele frequency- A:0.19MN NS EA NA WA CSA 854
    rs788946781,2
    C,F--137321009(+) AAACAG/ACCCTA 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1913376821,2
    --137321065(+) TATTAA/GGTACT 1 -- ds50010--------
    rs1389619111,2
    --137321298(+) TGAAAC/TTGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IL20RA (137321108 - 137366298 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL20RA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv349973CNV Loss16902084

    Human Gene Mutation Database (HGMD): IL20RA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL20RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL20RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605620    OMIM disorders: --

    1 disease for IL20RA:    
    About MalaCards
    psoriasis

    1 disease from the University of Copenhagen DISEASES database for IL20RA:
    Psoriasis

    Find genes that share disorders with IL20RA           About GenesLikeMe

    1 Novoseek inferred disease relationship for IL20RA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 56.9 5 18480827 (4)

    Genetic Association Database (GAD): IL20RA
    Human Genome Epidemiology (HuGE) Navigator: IL20RA (8 documents)

    Export disorders for IL20RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL20RA gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with IL20RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PubMed id 11163236)1, 2, 3 Blumberg H.... Chandrasekher Y.A. (Cell 2001)
    2. Association analysis of IL20RA and IL20RB genes in psoriasis. (PubMed id 18480827)1, 4, 9 Kingo K....KA/ks S. (Genes Immun. 2008)
    3. IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PubMed id 14764663)1, 2, 9 Sheikh F.... Kotenko S.V. (J. Immunol. 2004)
    4. Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis. (PubMed id 19926456)1, 4 Kingo K....KA/ks S. (J. Dermatol. Sci. 2010)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. (PubMed id 14580208)1, 2 Pletnev S.... Zdanov A. (Biochemistry 2003)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 53832 HGNC: 6003 AceView: IL20RA Ensembl:ENSG00000016402 euGenes: HUgn53832
    ECgene: IL20RA Kegg: 53832 H-InvDB: IL20RA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL20RA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IL20RA gene:
    Search GeneIP for patents involving IL20RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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