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Aliases for IL20RA Gene

Aliases for IL20RA Gene

  • Interleukin 20 Receptor, Alpha 2 3
  • Cytokine Receptor Family 2 Member 8 3 4
  • IL-20R-Alpha 3 4
  • IL-20R1 3 4
  • IL-20RA 3 4
  • CRF2-8 3 4
  • Interleukin-20 Receptor Subunit Alpha 3
  • Cytokine Receptor Class-II Member 8 4
  • Class II Cytokine Receptor ZCYTOR7 3
  • IL-20 Receptor Subunit Alpha 4
  • Interleukin-20 Receptor I 3
  • ZcytoR7 4

External Ids for IL20RA Gene

Previous GeneCards Identifiers for IL20RA Gene

  • GC06M136944
  • GC06M137168
  • GC06M137301
  • GC06M137362
  • GC06M134884
  • GC06M137321

Summaries for IL20RA Gene

Entrez Gene Summary for IL20RA Gene

  • This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL20RA Gene

IL20RA (Interleukin 20 Receptor, Alpha) is a Protein Coding gene. Diseases associated with IL20RA include psoriasis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include interleukin-20 binding. An important paralog of this gene is IL22RA1.

UniProtKB/Swiss-Prot for IL20RA Gene

  • The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26

Gene Wiki entry for IL20RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL20RA Gene

Genomics for IL20RA Gene

Regulatory Elements for IL20RA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL20RA Gene

Start:
136,999,971 bp from pter
End:
137,045,180 bp from pter
Size:
45,210 bases
Orientation:
Minus strand

Genomic View for IL20RA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL20RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20RA Gene

Proteins for IL20RA Gene

  • Protein details for IL20RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHF4-I20RA_HUMAN
    Recommended name:
    Interleukin-20 receptor subunit alpha
    Protein Accession:
    Q9UHF4
    Secondary Accessions:
    • B4DLR5
    • F5H675
    • Q14CW2
    • Q6UWA9
    • Q96SH8

    Protein attributes for IL20RA Gene

    Size:
    553 amino acids
    Molecular mass:
    62485 Da
    Quaternary structure:
    • Heterodimer with IL20RB and heterodimer with IL10RB.

    Three dimensional structures from OCA and Proteopedia for IL20RA Gene

    Alternative splice isoforms for IL20RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20RA Gene

Proteomics data for IL20RA Gene at MOPED

Post-translational modifications for IL20RA Gene

  • Glycosylation at Asn42, Asn83, Asn91, Asn182, Asn191, and Asn200
  • Modification sites at PhosphoSitePlus

Other Protein References for IL20RA Gene

Antibody Products

  • R&D Systems Antibodies for IL20RA (IL-20 R alpha)

No data available for DME Specific Peptides for IL20RA Gene

Domains for IL20RA Gene

Gene Families for IL20RA Gene

HGNC:
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL20RA Gene

Suggested Antigen Peptide Sequences for IL20RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHF4

UniProtKB/Swiss-Prot:

I20RA_HUMAN :
  • Q9UHF4
Domain:
  • Contains 2 fibronectin type-III domains.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL20RA: view

Function for IL20RA Gene

Molecular function for IL20RA Gene

UniProtKB/Swiss-Prot Function:
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26

Gene Ontology (GO) - Molecular Function for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA --
GO:0005515 protein binding --
GO:0042015 interleukin-20 binding IBA --
genes like me logo Genes that share ontologies with IL20RA: view

Phenotypes for IL20RA Gene

genes like me logo Genes that share phenotypes with IL20RA: view

Animal Models for IL20RA Gene

MGI Knock Outs for IL20RA:

Animal Model Products

miRNA for IL20RA Gene

miRTarBase miRNAs that target IL20RA

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL20RA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL20RA Gene

Localization for IL20RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL20RA Gene COMPARTMENTS Subcellular localization image for IL20RA gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IL20RA: view

Pathways for IL20RA Gene

genes like me logo Genes that share pathways with IL20RA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0045124 regulation of bone resorption IEA --
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with IL20RA: view

Transcripts for IL20RA Gene

Unigene Clusters for IL20RA Gene

Interleukin 20 receptor, alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL20RA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL20RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for IL20RA Gene

GeneLoc Exon Structure for
IL20RA
ECgene alternative splicing isoforms for
IL20RA

Expression for IL20RA Gene

mRNA expression in normal human tissues for IL20RA Gene

mRNA differential expression in normal tissues according to GTEx for IL20RA Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (7.5) and Skin - Sun Exposed (Lower leg) (6.8).

SOURCE GeneReport for Unigene cluster for IL20RA Gene Hs.445868

mRNA Expression by UniProt/SwissProt for IL20RA Gene

Q9UHF4-I20RA_HUMAN
Tissue specificity: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.
genes like me logo Genes that share expressions with IL20RA: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for IL20RA Gene

Orthologs for IL20RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20RA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL20RA 35
  • 82.41 (n)
  • 75.81 (a)
IL20RA 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL20RA 35
  • 80.69 (n)
  • 74.57 (a)
IL20RA 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il20ra 35
  • 74.47 (n)
  • 64.99 (a)
Il20ra 16
Il20ra 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL20RA 35
  • 99.28 (n)
  • 99.28 (a)
IL20RA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il20ra 35
  • 73.41 (n)
  • 63.81 (a)
oppossum
(Monodelphis domestica)
Mammalia IL20RA 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL20RA 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL20RA 35
  • 55.49 (n)
  • 43.47 (a)
IL20RA 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crfb8 35
  • 45.25 (n)
  • 34.49 (a)
crfb8 36
  • 25 (a)
OneToOne
Species with no ortholog for IL20RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL20RA Gene

ENSEMBL:
Gene Tree for IL20RA (if available)
TreeFam:
Gene Tree for IL20RA (if available)

Paralogs for IL20RA Gene

Paralogs for IL20RA Gene

genes like me logo Genes that share paralogs with IL20RA: view

Variants for IL20RA Gene

Sequence variations from dbSNP and Humsavar for IL20RA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs45758 -- 137,020,546(+) CTTAA(C/T)AATTT intron-variant
rs140799 -- 137,021,827(-) AGGAT(-/TTAG)TAAGT intron-variant
rs276476 -- 137,020,246(+) TCCTC(C/T)GACCC intron-variant
rs276477 -- 137,020,837(+) TGCAG(G/T)TTCTT intron-variant
rs276478 -- 137,021,234(-) CATCT(A/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL20RA Gene

Variant ID Type Subtype PubMed ID
nsv349973 CNV Loss 16902084

Relevant External Links for IL20RA Gene

HapMap Linkage Disequilibrium report
IL20RA
Human Gene Mutation Database (HGMD)
IL20RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20RA Gene

Disorders for IL20RA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IL20RA Gene in MalaCards »

(1) Diseases for IL20RA Gene including...

(1) University of Copenhagen DISEASES for IL20RA Gene

(1) Novoseek inferred disease relationships for IL20RA Gene

Disease -log(P) Hits PubMed IDs
psoriasis 56.9 4

Relevant External Links for IL20RA

Genetic Association Database (GAD)
IL20RA
Human Genome Epidemiology (HuGE) Navigator
IL20RA
genes like me logo Genes that share disorders with IL20RA: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IL20RA Gene

Publications for IL20RA Gene

  1. IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PMID: 14764663) Sheikh F. … Kotenko S.V. (J. Immunol. 2004) 3 4 23
  2. Association analysis of IL20RA and IL20RB genes in psoriasis. (PMID: 18480827) Kingo K. … KA/ks S. (Genes Immun. 2008) 3 23 48
  3. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H. … Chandrasekher Y.A. (Cell 2001) 2 3 4
  4. STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. (PMID: 11564763) Dumoutier L. … Renauld J.-C. (J. Immunol. 2001) 3 4
  5. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. (PMID: 12351624) Parrish-Novak J. … Chandrasekher Y.A. (J. Biol. Chem. 2002) 3 4

Products for IL20RA Gene

Sources for IL20RA Gene

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