IL20 Gene

Aliases
for IL20 gene

Previous GC identifers: GC01P205699 GC01P202749 GC01P203682 GC01P204122 GC01P203427 GC01P205105 GC01P177737

Summaries
for IL20 gene

Genomic Views
for IL20 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_167186.1  

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL20 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL20

IL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207038:  view genomic region     (about GC identifiers)

Proteins
for IL20 gene

1 PDB 3D structure from and Proteopedia for IL20:

4DOH (3D)    

Explore the universe of human proteins at neXtProt for IL20: NX_Q9NYY1

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL20 (IL-20)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IL20 OriGene Protein Over-expression Lysate: IL20 OriGene Custom Protein Services for IL20
	GenScript Purified and Recombinant Proteins for IL20
	Novus Biologicals IL20 Proteins Novus Biologicals IL20 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL20
	Uscn Proteins for IL20

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IL20 (IL-20)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IL20
	GenScript Custom Superior Antibodies Services for IL20
	Novus Biologicals IL20 Antibodies
	Abcam antibodies for IL20
	Uscn Antibodies for IL20
	Search ThermoFisher Antibodies for IL20

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL20 (IL-20)
	GenScript Custom Assay Services for IL20
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL20

Protein Domains /
Families
for IL20 gene

ProtoNet protein and cluster: Q9NYY1

Function
for IL20 gene

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL20

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL20
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate IL20:
		hsa-miR-548p hsa-miR-634 hsa-miR-3674 hsa-miR-3121-3p hsa-miR-876-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IL20 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL20 (see all 7) OriGene shRNA RFP: IL20 OriGene siRNA: IL20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL20
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL20

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IL20
			Sirion Biotech Customized adenovirus for overexpression of IL20  Sirion Biotech Customized adenovirus for potent knockdown of IL20

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL20 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL20 (NM_018724)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL20
		Search LifeMap BioReagents cell lines for IL20
		Sirion Biotech Customized stable knockdown cell line services for IL20  Sirion Biotech Customized inducible knockdown cell line services for IL20 Sirion Biotech Customized stable overexpressing cell line services for IL20 Sirion Biotech Customized inducible overexpressing cell line services for IL20

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20

Pathways & Interactions
for IL20 gene

	Super-pathway	contained gene-specific pathways
1	PEDF Induced Signaling	8/12 pathways (see all 12) PEDF Induced Signaling 1.00 STAT3 Pathway 0.47 MIF Mediated Glucocorticoid Regulation 0.73 Endothelin-1 Signaling Pathway 0.44 MIF Regulation of Innate Immune Cells 0.71 NFAT Signaling and Lymphocyte Interactions 0.37 IL-6 Pathway 0.61 PGC1Alpha Pathway 0.33
2	TGF-Beta Pathway	TGF-Beta Pathway 1.00 Regulation of eIF4 and p70S6K 0.43 MAPK Family Pathway 0.60 SOCS Pathway 0.29 JAK-STAT Pathway 0.57
3	Akt Signaling	Akt Signaling 1.00 Tec Kinases Signaling 0.55 p38 Signaling 0.60
4	Rho Family GTPases	Rho Family GTPases 1.00 Molecular Mechanisms of Cancer 0.51 ERK Signaling 0.61
5	PAK Pathway	PAK Pathway 1.00 Antioxidant Action of Vitamin-C 0.56

5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL20

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	Tec Kinases Signaling

2         Kegg Pathways  (Kegg details for IL20)

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for IL20 gene

Transcripts
for IL20 gene

Expression
for IL20 gene

IL20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTCTACA

About this image

IL20 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverHepatic MesenchymeMesothelial Cells			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL20 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL20
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL20
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL20

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20

Orthologs
for IL20 gene

Paralogs
for IL20 gene

Paralogs for IL20 gene

IL19²  IL24²  

2 SIMAP similar genes for IL20 using alignment to 2 protein entries:     IL20_HUMAN (see all proteins):

IL19    IL24

IL20 for paralogs           About GeneDecksing

Genomic Variants
for IL20 gene

10/107 NCBI SNPs in IL20 are shown (see all 107)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1451545081,2		--	207037337(+)	AATTAA/TACTCA	1	--	us2k1		0	--	--	--	--
rs761859701,2	F	--	207037457(+)	ATTCCC/GTGCCC	1	--	us2k1		1		EA	120
rs1475801821,2		--	207037474(+)	CTCAGC/TGCTGG	1	--	us2k1		0	--	--	--	--
rs17132391,2	C,F,A,H	--	207037475(-)	CCCAGG/CACTGA	1	--	us2k1		26		NS EA NA WA CSA	1532
rs1419976221,2		--	207037606(+)	TTTTCC/TTACAT	1	--	us2k1		0	--	--	--	--
rs30245141,2	C,F,H	--	207037701(+)	ATTATC/TAGTGC	1	--	us2k1		20		NS EA NA WA	1906
rs1485764301,2		--	207037750(+)	TGTGC-/ATATATA	1	--	us2k1		0	--	--	--	--
rs1890502731,2		--	207037759(+)	ATATAC/TATGAT	1	--	us2k1		0	--	--	--	--
rs1457471811,2		--	207037789(+)	TCTTTA/TTAAAT	1	--	us2k1		0	--	--	--	--
rs1815484251,2		--	207037831(+)	AGTATC/TTGAGA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL20 (207038699 - 207042568 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IL20
     2 CNVs: 84808 2091
Human Gene Mutation Database (HGMD): IL20

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL20

DNA2.0 Custom Variant and Variant Library Synthesis for IL20

Disorders / Diseases
for IL20 gene

18 diseases for IL20

8 Novoseek disease relationships for IL20 gene    About this table

Publications
for IL20 gene

PubMed articles for IL20 gene, integrated from 9 sources (see all 91): (articles sorted by number of sources associating them with IL20)

Utopia: connect your pdf to the dynamic world of online information

1. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PubMed id 11163236)^{1, 2, 3} Blumberg H.... Chandrasekher Y.A. (2001)
2. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PubMed id 15815689)^{1, 4, 9} Oleksyk T.K....Smith M.W. (2005)
3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects. (PubMed id 16645593)^{1, 9} Wang F....Krueger J.G. (2006)
7. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. (PubMed id 19342680)^{1, 9} Chen W.Y. and Chang M.S. (2009)
8. IL-20 gene expression is induced by IL-1beta through mitogen-activated protein kinase and NF-kappaB-dependent mechanisms. (PubMed id 17255956)^{1, 9} Otkjaer K....Iversen L. (2007)
9. The Th17 cytokine IL-22 induces IL-20 production in k eratinocytes: a novel immunological cascade with potential relevance in psorias is. (PubMed id 19830738)^{1, 9} Wolk K....Sabat R. (2009)
10. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PubMed id 17263806)^{1, 9} Kingo K....Silm H. (2007)

External Searches for IL20 gene

Genome Databases showing IL20 gene

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Specialized Databases showing IL20 gene

Products
for IL20 gene