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Aliases for IL20 Gene

Aliases for IL20 Gene

  • Interleukin 20 2 3
  • Cytokine Zcyto10 3 4
  • ZCYTO10 3 4
  • IL-20 3 4
  • Four Alpha Helix Cytokine 3
  • Interleukin-20 3
  • IL10D 3

External Ids for IL20 Gene

Previous GeneCards Identifiers for IL20 Gene

  • GC01P205699
  • GC01P202749
  • GC01P203682
  • GC01P204122
  • GC01P203427
  • GC01P205105
  • GC01P207038
  • GC01P177737

Summaries for IL20 Gene

Entrez Gene Summary for IL20 Gene

  • The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL20 Gene

IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include psoriasis and spondyloarthropathy. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL24.

UniProtKB/Swiss-Prot for IL20 Gene

  • Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL20 Gene

Genomics for IL20 Gene

Regulatory Elements for IL20 Gene

Genomic Location for IL20 Gene

Start:
206,865,354 bp from pter
End:
206,869,223 bp from pter
Size:
3,870 bases
Orientation:
Plus strand

Genomic View for IL20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20 Gene

Proteins for IL20 Gene

  • Protein details for IL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYY1-IL20_HUMAN
    Recommended name:
    Interleukin-20
    Protein Accession:
    Q9NYY1
    Secondary Accessions:
    • Q17RB3
    • Q2THG6
    • Q96QZ6

    Protein attributes for IL20 Gene

    Size:
    176 amino acids
    Molecular mass:
    20072 Da
    Quaternary structure:
    • Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.

    Three dimensional structures from OCA and Proteopedia for IL20 Gene

    Alternative splice isoforms for IL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20 Gene

Proteomics data for IL20 Gene at MOPED

Post-translational modifications for IL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL20 Gene

Domains for IL20 Gene

Gene Families for IL20 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Suggested Antigen Peptide Sequences for IL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYY1

UniProtKB/Swiss-Prot:

IL20_HUMAN :
  • Q9NYY1
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL20: view

Function for IL20 Gene

Molecular function for IL20 Gene

UniProtKB/Swiss-Prot Function: Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
UniProtKB/Swiss-Prot Induction: Up-regulated by UV-B irradiation in epithelial keratinocytes.

Gene Ontology (GO) - Molecular Function for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0045517 interleukin-20 receptor binding TAS 11470428
GO:0045518 interleukin-22 receptor binding IBA --
genes like me logo Genes that share ontologies with IL20: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL20 Gene

Localization for IL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL20 Gene COMPARTMENTS Subcellular localization image for IL20 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 11470428
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL20: view

Pathways for IL20 Gene

genes like me logo Genes that share pathways with IL20: view

Pathways by source for IL20 Gene

Gene Ontology (GO) - Biological Process for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein TAS 11470428
GO:0045606 positive regulation of epidermal cell differentiation TAS 11470428
GO:0045618 positive regulation of keratinocyte differentiation TAS 11470428
genes like me logo Genes that share ontologies with IL20: view

Compounds for IL20 Gene

(2) Novoseek inferred chemical compound relationships for IL20 Gene

Compound -log(P) Hits PubMed IDs
il 10 67.7 2
calcipotriol 52.9 1
genes like me logo Genes that share compounds with IL20: view

Transcripts for IL20 Gene

mRNA/cDNA for IL20 Gene

(15) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL20 Gene

Interleukin 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL20 Gene

No ASD Table

Relevant External Links for IL20 Gene

GeneLoc Exon Structure for
IL20
ECgene alternative splicing isoforms for
IL20

Expression for IL20 Gene

mRNA expression in normal human tissues for IL20 Gene

mRNA differential expression in normal tissues according to GTEx for IL20 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (12.3), Adipose - Visceral (Omentum) (9.9), and Skin - Sun Exposed (Lower leg) (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL20 Gene

SOURCE GeneReport for Unigene cluster for IL20 Gene Hs.272373

mRNA Expression by UniProt/SwissProt for IL20 Gene

Q9NYY1-IL20_HUMAN
Tissue specificity: Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.
genes like me logo Genes that share expressions with IL20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL20 Gene

Orthologs for IL20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL20 35
  • 99.62 (n)
  • 100 (a)
IL20 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL20 35
  • 83.9 (n)
  • 76.7 (a)
IL20 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL20 35
  • 87.88 (n)
  • 85.8 (a)
IL20 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il20 35
  • 82.38 (n)
  • 75.86 (a)
Il20 16
Il20 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL20 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL20 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il20 35
  • 80.46 (n)
  • 74.71 (a)
chicken
(Gallus gallus)
Aves IL19 35
  • 54.67 (n)
  • 41.14 (a)
zebrafish
(Danio rerio)
Actinopterygii il19l 36
  • 36 (a)
OneToMany
il34 35
  • 52.63 (n)
  • 43.42 (a)
Species with no ortholog for IL20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL20 Gene

ENSEMBL:
Gene Tree for IL20 (if available)
TreeFam:
Gene Tree for IL20 (if available)

Paralogs for IL20 Gene

Paralogs for IL20 Gene

Selected SIMAP similar genes for IL20 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL20: view

Variants for IL20 Gene

Sequence variations from dbSNP and Humsavar for IL20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1109461 -- 206,868,458(-) GGTTA(A/G)CAATT intron-variant
rs1400986 -- 206,865,341(+) TTCCC(C/T)CTAGG upstream-variant-2KB
rs1713239 -- 206,864,130(-) CCCAG(C/G)ACTGA upstream-variant-2KB
rs2232356 -- 206,865,796(+) AGTAA(A/G)TCATG upstream-variant-2KB, intron-variant
rs2232357 -- 206,866,216(+) GGCAG(C/G)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL20 Gene

Variant ID Type Subtype PubMed ID
esv2660993 CNV Deletion 23128226

Relevant External Links for IL20 Gene

HapMap Linkage Disequilibrium report
IL20
Human Gene Mutation Database (HGMD)
IL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20 Gene

Disorders for IL20 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IL20 Gene including...

Search for IL20 Gene in MalaCards »

(8) Novoseek inferred disease relationships for IL20 Gene

Disease -log(P) Hits PubMed IDs
psoriasis 74.8 27
skin lesion 33.3 2
inflammation 32.8 6
melanoma 13.6 4
necrosis 0 1

Relevant External Links for IL20

Genetic Association Database (GAD)
IL20
Human Genome Epidemiology (HuGE) Navigator
IL20
genes like me logo Genes that share disorders with IL20: view

No data available for UniProtKB/Swiss-Prot for IL20 Gene

Publications for IL20 Gene

  1. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K. … Silm H. (Br. J. Dermatol. 2007) 3 23 48
  2. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PMID: 15815689) Oleksyk T.K. … Smith M.W. (Genes Immun. 2005) 3 23 48
  3. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T. … KA/ks S. (BMC Med. Genet. 2008) 3 23 48
  4. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H. … Chandrasekher Y.A. (Cell 2001) 2 3 4
  5. Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. (PMID: 12855566) Liu L. … Broxmeyer H.E. (Blood 2003) 3 23

Products for IL20 Gene

Sources for IL20 Gene

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