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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL20 Gene

protein-coding   GIFtS: 56
GCID: GC01P207038

Interleukin 20

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 201 2     IL10D2
Cytokine Zcyto102 3     Four Alpha Helix Cytokine2
IL-202 3     interleukin-202
ZCYTO102 3     

External Ids:    HGNC: 60021   Entrez Gene: 506042   Ensembl: ENSG000001628917   OMIM: 6056195   UniProtKB: Q9NYY13   

Export aliases for IL20 gene to outside databases

Previous GC identifers: GC01P205699 GC01P202749 GC01P203682 GC01P204122 GC01P203427 GC01P205105 GC01P177737


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL20 Gene:
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has
been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in
keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated
dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. (provided
by RefSeq, Jul 2008)

GeneCards Summary for IL20 Gene: 
IL20 (interleukin 20) is a protein-coding gene. Diseases associated with IL20 include spondyloarthropathy, and psoriasis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include interleukin-20 receptor binding and cytokine activity. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1
Function: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL20 gene promoter:
         Elk-1   AML1a   AP-1   ATF-2   Nkx2-5   STAT5A   c-Jun   E4BP4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL20 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

IL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207038:  view genomic region     (about GC identifiers)

Start:
207,038,699 bp from pter      End:
207,042,568 bp from pter
Size:
3,870 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1 (See protein sequence)
Recommended Name: Interleukin-20 precursor  
Size: 176 amino acids; 20072 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IL20:
4DOH (3D)    
Secondary accessions: Q17RB3 Q96QZ6

Explore the universe of human proteins at neXtProt for IL20: NX_Q9NYY1

Explore proteomics data for IL20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYY1

  • IL20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL20 Protein Expression
    REFSEQ proteins: NP_061194.2  
    ENSEMBL proteins: 
     ENSP00000356065   ENSP00000356063   ENSP00000375796  

    Human Recombinant Protein Products for IL20: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL20 (IL-20)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL20
    OriGene Protein Over-expression Lysate for IL20
    OriGene MassSpec for IL20 
    OriGene Custom Protein Services for IL20
    GenScript Purified and Recombinant Proteins for IL20
    Novus Biologicals IL20 Proteins
    Novus Biologicals IL20 Lysates
    Sino Biological Recombinant Protein for IL20
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL20
    Cloud-Clone Corp. Proteins for IL20 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS11470428
    GO:0005615extracellular space IEA--

    IL20 for ontologies           About GeneDecksing



    IL20 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL20 (IL-20)
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    Novus Biologicals IL20 Antibodies
    Abcam antibodies for IL20
    Cloud-Clone Corp. Antibodies for IL20 
    ThermoFisher Antibodies for IL20
    LSBio Antibodies in human, mouse, rat for IL20 

    Assay Products for IL20: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IL20 (IL-20)
    GenScript Custom Assay Services for IL20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL20 
    Cloud-Clone Corp. CLIAs for IL20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR020442 Interleukin-20
     IPR012351 4_helix_cytokine_core
     IPR020423 Interleukin-10_CS
     IPR009079 4_helix_cytokine-like_core
     IPR020443 Interleukin-10/19/20/24

    Graphical View of Domain Structure for InterPro Entry Q9NYY1

    ProtoNet protein and cluster: Q9NYY1

    1 Blocks protein domain: IPB000098 Interleukin-10

    UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1
    Similarity: Belongs to the IL-10 family


    IL20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL20_HUMAN, Q9NYY1
    Function: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005125cytokine activity IEA--
    GO:0045517interleukin-20 receptor binding TAS11470428
    GO:0045518interleukin-22 receptor binding IEA--
         
    IL20 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Il20 (no phenotypes)

    IL20 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il20tm1Lex for IL20

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL20 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL20 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL20
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate IL20:
    hsa-miR-548p hsa-miR-634 hsa-miR-3674 hsa-miR-3121-3p hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL20 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL20
    Sirion Biotech Customized adenovirus for overexpression of IL20

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL20 (see all 6)
    OriGene ORF clones in mouse, rat for IL20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL20 (NM_018724)
    Sino Biological Human cDNA Clone for IL20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20
    Sirion Biotech Customized lentivirus for stable overexpression of IL20 
                         Customized lentivirus expression plasmids for stable overexpression of IL20 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL20
    Search LifeMap BioReagents cell lines for IL20
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL20 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL20 (see all 24)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling



    2         Kegg Pathways  (Kegg details for IL20):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IL20 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL20

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IL20 (Q9NYY13 ENSP000003560634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL20RBQ6UXL03, ENSP000003281334I2D: score=2 STRING: ENSP00000328133
    IL20RAQ9UHF43, ENSP000003149764I2D: score=1 STRING: ENSP00000314976
    IL22RA1ENSP000002708004STRING: ENSP00000270800
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein TAS11470428
    GO:0045606positive regulation of epidermal cell differentiation TAS11470428
    GO:0045618positive regulation of keratinocyte differentiation TAS11470428
    GO:0045672positive regulation of osteoclast differentiation IEA--
    GO:0050727regulation of inflammatory response TAS11470428

    IL20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL20

    2 Novoseek inferred chemical compound relationships for IL20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 10 67.7 2 15815689 (1), 18717682 (1)
    calcipotriol 52.9 1 16225599 (1)

    Search CenterWatch for drugs/clinical trials and news about IL20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL20 gene: 
    NM_018724.3  

    Unigene Cluster for IL20:

    Interleukin 20
    Hs.272373  [show with all ESTs]
    Unigene Representative Sequence: AY358320
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367098(uc001her.3 uc009xby.3) ENST00000367096 ENST00000391930


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL20
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate IL20:
    hsa-miR-548p hsa-miR-634 hsa-miR-3674 hsa-miR-3121-3p hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL20 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL20
    Clone
    Products:
         
    OriGene clones in human, mouse for IL20 (see all 6)
    OriGene ORF clones in mouse, rat for IL20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL20 (NM_018724)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20
    Sirion Biotech Customized lentivirus for stable overexpression of IL20 
                         Customized lentivirus expression plasmids for stable overexpression of IL20 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IL20
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL20
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL20

    Additional mRNA sequence: 

    AF224266.1 AY358320.1 AY876922.1 BC069311.1 BC069364.1 BC069398.1 BC069425.1 BC069449.1 
    BC069487.1 BC069523.1 BC069559.1 BC074948.2 BC074949.2 BC117386.1 BC117390.1 

    1 DOTS entry:

    DT.101967900 

    13 AceView cDNA sequences:

    BC069559 BC069449 BC069398 BC074948 BC069487 BC069364 BC069523 NM_018724 
    BC069311 BC074949 BC069425 AF224266 AY358320 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTCTACA
    IL20 Expression
    About this image


    See IL20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL20

    SOURCE GeneReport for Unigene cluster: Hs.272373

    UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1
    Tissue specificity: Expressed at very low levels in skin, trachea, and other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL20: 
              Common Cytokines in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IL20
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL20 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il201 , 5 interleukin 201, 5 82.38(n)1
    75.86(a)1
      1 (56.89 cM)5
    581811  NM_021380.11  NP_067355.11 
     1309071925 
    chicken
    (Gallus gallus)
    Aves IL191 interleukin 19 54.67(n)
    41.14(a)
      428265  XM_425824.2  XP_425824.2 
    zebrafish
    (Danio rerio)
    Actinopterygii il341 interleukin 34 53.07(n)
    44.08(a)
      100004224  NM_001082955.1  NP_001076424.1 


    ENSEMBL Gene Tree for IL20 (if available)
    TreeFam Gene Tree for IL20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL20 gene
    IL192  IL242  
    2 SIMAP similar genes for IL20 using alignment to 2 protein entries:     IL20_HUMAN (see all proteins):
    IL19    IL24

    IL20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 SNPs in IL20 are shown (see all 148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451545081,2
    --207037337(+) AATTAA/TACTCA 1 -- us2k10--------
    rs761859701,2
    C,F--207037457(+) ATTCCC/GTGCCC 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1475801821,2
    --207037474(+) CTCAGC/TGCTGG 1 -- us2k10--------
    rs17132391,2
    C,F,A,H--207037475(-) CCCAGG/CACTGA 1 -- us2k126Minor allele frequency- C:0.19NS EA NA WA CSA 1532
    rs1419976221,2
    --207037606(+) TTTTCC/TTACAT 1 -- us2k10--------
    rs30245141,2
    C,F,H--207037701(+) ATTATC/TAGTGC 1 -- us2k120Minor allele frequency- T:0.37NS EA NA WA 1906
    rs1485764301,2
    C--207037750(+) TGTGC-/ATATATA 1 -- us2k10--------
    rs1890502731,2
    --207037759(+) ATATAC/TATGAT 1 -- us2k10--------
    rs1457471811,2
    --207037789(+) TCTTTA/TTAAAT 1 -- us2k10--------
    rs1815484251,2
    --207037831(+) AGTATC/TTGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL20 (207038699 - 207042568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL20:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660993CNV Deletion23128226


    Human Gene Mutation Database (HGMD): IL20
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL20
    DNA2.0 Custom Variant and Variant Library Synthesis for IL20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605619    OMIM disorders: --

    19 diseases for IL20:    About MalaCards
    spondyloarthropathy    psoriasis    major depressive disorder    lupus nephritis
    vitiligo    nephritis    bronchiolitis    uveitis
    skin disease    hypoxia    inflammatory bowel disease    hepatitis b
    type 1 diabetes    atherosclerosis    obesity    asthma
    rheumatoid arthritis    arthritis    hepatitis


    IL20 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    8 Novoseek inferred disease relationships for IL20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 74.8 29 16645593 (4), 15889129 (4), 19330474 (3), 16225599 (3) (see all 16)
    skin lesion 33.3 2 16225599 (1), 19731362 (1)
    inflammation 32.8 6 12667095 (3), 17263806 (1), 16645593 (1), 12635355 (1)
    melanoma 13.6 4 12370360 (1), 15557163 (1), 11564763 (1), 11929132 (1)
    necrosis 0 1 19054079 (1)
    tumors 0 2 16731153 (1), 12351624 (1)
    cancer 0 2 17255956 (1)
    hyperplasia 0 2 16645593 (1)

    Genetic Association Database (GAD): IL20
    Human Genome Epidemiology (HuGE) Navigator: IL20 (14 documents)

    Export disorders for IL20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL20 gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with IL20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PubMed id 11163236)1, 2, 3 Blumberg H.... Chandrasekher Y.A. (2001)
    2. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PubMed id 17263806)1, 4, 9 Kingo K....Silm H. (2007)
    3. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PubMed id 19087313)1, 4, 9 Traks T....KA/ks S. (2008)
    4. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PubMed id 15815689)1, 4, 9 Oleksyk T.K....Smith M.W. (2005)
    5. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    6. Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents. (PubMed id 20976276)1, 4 Shrestha S....Tang J. (2010)
    7. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    9. Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome. (PubMed id 18479293)1, 4 Truelove A.L....Smith M.W. (2008)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50604 HGNC: 6002 AceView: IL20 Ensembl:ENSG00000162891 euGenes: HUgn50604
    ECgene: IL20 Kegg: 50604 H-InvDB: IL20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL20 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il20/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL20 gene:
    Search GeneIP for patents involving IL20

    GeneCards and IP:
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