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IL20 Gene

protein-coding   GIFtS: 54
GCID: GC01P207038

Interleukin 20

  See IL20-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 201 2     IL10D2
Cytokine Zcyto102 3     Four Alpha Helix Cytokine2
IL-202 3     interleukin-202
ZCYTO102 3     

External Ids:    HGNC: 60021   Entrez Gene: 506042   Ensembl: ENSG000001628917   OMIM: 6056195   UniProtKB: Q9NYY13   

Export aliases for IL20 gene to outside databases

Previous GC identifers: GC01P205699 GC01P202749 GC01P203682 GC01P204122 GC01P203427 GC01P205105 GC01P177737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL20 Gene:
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has
been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in
keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated
dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. (provided
by RefSeq, Jul 2008)

GeneCards Summary for IL20 Gene:
IL20 (interleukin 20) is a protein-coding gene. Diseases associated with IL20 include psoriasis, and spondyloarthropathy. GO annotations related to this gene include interleukin-20 receptor binding and cytokine activity. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1
Function: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL20 gene promoter:
         Elk-1   AML1a   AP-1   ATF-2   Nkx2-5   STAT5A   c-Jun   E4BP4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL20 promoter sequence
   Search Chromatin IP Primers for IL20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

IL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207038:  view genomic region     (about GC identifiers)

Start:
207,038,699 bp from pter      End:
207,042,568 bp from pter
Size:
3,870 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1 (See protein sequence)
Recommended Name: Interleukin-20 precursor  
Size: 176 amino acids; 20072 Da
1 PDB 3D structure from and Proteopedia for IL20:
4DOH (3D)    
Secondary accessions: Q17RB3 Q96QZ6

Explore the universe of human proteins at neXtProt for IL20: NX_Q9NYY1

Explore proteomics data for IL20 at MOPED


See IL20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_061194.2  
ENSEMBL proteins: 
 ENSP00000356065   ENSP00000356063   ENSP00000375796  

IL20 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL20 (IL-20)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for IL20
OriGene Protein Over-expression Lysate for IL20
OriGene MassSpec for IL20
OriGene Custom Protein Services for IL20
GenScript Purified and Recombinant Proteins for IL20
Novus Biologicals IL20 Proteins
Novus Biologicals IL20 Lysates
Sino Biological Recombinant Protein for IL20
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for IL20
Cloud-Clone Corp. Proteins for IL20

 
Search eBioscience for Proteins for IL20 

IL20 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IL20 (IL-20)
OriGene Antibodies for IL20
OriGene Custom Antibody Services for IL20
Novus Biologicals IL20 Antibodies
Abcam antibodies for IL20
Cloud-Clone Corp. Antibodies for IL20
ThermoFisher Antibodies for IL20
LSBio Antibodies in human, mouse, rat for IL20

IL20 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL20
R&D Systems ELISAs for IL20 (IL-20)
GenScript Custom Assay Services for IL20
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL20
Cloud-Clone Corp. CLIAs for IL20
Search eBioscience for ELISAs for IL20 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IL: Interleukins and interleukin receptors

5 InterPro protein domains:
 IPR020442 IL-20
 IPR012351 4_helix_cytokine_core
 IPR020423 IL-10_CS
 IPR009079 4_helix_cytokine-like_core
 IPR020443 IL-10/19/20/24/26_fam

Graphical View of Domain Structure for InterPro Entry Q9NYY1

ProtoNet protein and cluster: Q9NYY1

1 Blocks protein domain: IPB000098 Interleukin-10

UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1
Similarity: Belongs to the IL-10 family


Find genes that share domains with IL20           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL20_HUMAN, Q9NYY1
Function: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding ----
GO:0005125cytokine activity IEA--
GO:0045517interleukin-20 receptor binding TAS11470428
GO:0045518interleukin-22 receptor binding IEA--
     
Find genes that share ontologies with IL20           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Il20 (no phenotypes)

Find genes that share phenotypes with IL20           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Il20tm1Lex for IL20

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL20
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL20

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL20
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL20

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat IL20 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate IL20:
hsa-miR-548p hsa-miR-634 hsa-miR-3674 hsa-miR-3121-3p hsa-miR-876-3p
SwitchGear 3'UTR luciferase reporter plasmidIL20 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IL20
Predesigned siRNA for gene silencing in human, mouse, rat IL20

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL20

Clone
Products:
     
OriGene clones in human, mouse for IL20 (see all 6)
OriGene ORF clones in mouse, rat for IL20
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL20 (NM_018724)
Sino Biological Human cDNA Clone for IL20
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL20
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL20
Browse ESI BIO Cell Lines and PureStem Progenitors for IL20 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IL20_HUMAN, Q9NYY1: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS11470428
GO:0005615extracellular space IEA--

Find genes that share ontologies with IL20           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL20 About   (see all 6)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
3Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
4ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
5PAK Pathway
PAK Pathway0.56
Antioxidant Action of Vitamin-C0.56


Find genes that share SuperPaths with IL20           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL20 (see all 24)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Tec Kinases Signaling



2 Kegg Pathways  (Kegg details for IL20):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL20: 
          Common Cytokines in human mouse rat
          JAK / STAT Signaling Pathway in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Hematopoiesis in human mouse rat

Interactions:

    GeneGlobe Interaction Network for IL20

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IL20 (Q9NYY13 ENSP000003560634) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL20RBQ6UXL03, ENSP000003281334I2D: score=2 STRING: ENSP00000328133
IL20RAQ9UHF43, ENSP000003149764I2D: score=1 STRING: ENSP00000314976
IL22RA1ENSP000002708004STRING: ENSP00000270800
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein TAS11470428
GO:0045606positive regulation of epidermal cell differentiation TAS11470428
GO:0045618positive regulation of keratinocyte differentiation TAS11470428
GO:0045672positive regulation of osteoclast differentiation IEA--
GO:0050727regulation of inflammatory response TAS11470428

Find genes that share ontologies with IL20           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IL20

2 Novoseek inferred chemical compound relationships for IL20 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
il 10 67.7 2 15815689 (1), 18717682 (1)
calcipotriol 52.9 1 16225599 (1)



Find genes that share compounds with IL20           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IL20 gene: 
NM_018724.3  

Unigene Cluster for IL20:

Interleukin 20
Hs.272373  [show with all ESTs]
Unigene Representative Sequence: AY358320
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000367098(uc001her.3 uc009xby.3) ENST00000367096 ENST00000391930

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IL20 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate IL20:
hsa-miR-548p hsa-miR-634 hsa-miR-3674 hsa-miR-3121-3p hsa-miR-876-3p
SwitchGear 3'UTR luciferase reporter plasmidIL20 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IL20
Predesigned siRNA for gene silencing in human, mouse, rat IL20
Clone
Products:
     
OriGene clones in human, mouse for IL20 (see all 6)
OriGene ORF clones in mouse, rat for IL20
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL20 (NM_018724)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL20
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL20
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IL20
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL20
  QuantiTect SYBR Green Assays in human, mouse, rat IL20
  QuantiFast Probe-based Assays in human, mouse, rat IL20

Additional mRNA sequence: 

AF224266.1 AY358320.1 AY876922.1 BC069311.1 BC069364.1 BC069398.1 BC069425.1 BC069449.1 
BC069487.1 BC069523.1 BC069559.1 BC074948.2 BC074949.2 BC117386.1 BC117390.1 

1 DOTS entry:

DT.101967900 

13 AceView cDNA sequences:

BC069364 BC069398 BC074949 BC069523 BC069425 BC069311 NM_018724 BC074948 
BC069559 BC069487 BC069449 AF224266 AY358320 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATTTCTACA
IL20 Expression
About this image

IL20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IL20 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.272373

UniProtKB/Swiss-Prot: IL20_HUMAN, Q9NYY1
Tissue specificity: Expressed at very low levels in skin, trachea, and other tissues

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL20: 
          Common Cytokines in human mouse rat
          JAK / STAT Signaling Pathway in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Hematopoiesis in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IL20
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL20
QuantiTect SYBR Green Assays in human, mouse, rat IL20
QuantiFast Probe-based Assays in human, mouse, rat IL20
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL20

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL20 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il201 , 5 interleukin 201, 5 82.38(n)1
75.86(a)1
  1 (56.89 cM)5
581811  NM_021380.11  NP_067355.11 
 1309071925 
chicken
(Gallus gallus)
Aves IL191 interleukin 19 54.67(n)
41.14(a)
  428265  XM_425824.3  XP_425824.2 
zebrafish
(Danio rerio)
Actinopterygii il341 interleukin 34 52.63(n)
43.42(a)
  100004224  NM_001082955.1  NP_001076424.1 


ENSEMBL Gene Tree for IL20 (if available)
TreeFam Gene Tree for IL20 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IL20 gene
IL192  IL242  
2 SIMAP similar genes for IL20 using alignment to 2 protein entries:     IL20_HUMAN (see all proteins):
IL19    IL24

Find genes that share paralogs with IL20           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL20 (see all 148)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1451545081,2
--207037337(+) AATTAA/TACTCA 1 -- us2k10--------
rs761859701,2
C,F--207037457(+) ATTCCC/GTGCCC 1 -- us2k11Minor allele frequency- G:0.03EA 120
rs1475801821,2
--207037474(+) CTCAGC/TGCTGG 1 -- us2k10--------
rs17132391,2
C,F,A,H--207037475(-) CCCAGG/CACTGA 1 -- us2k126Minor allele frequency- C:0.19NS EA NA WA CSA 1532
rs1419976221,2
--207037606(+) TTTTCC/TTACAT 1 -- us2k10--------
rs30245141,2
C,F,H--207037701(+) ATTATC/TAGTGC 1 -- us2k120Minor allele frequency- T:0.37NS EA NA WA 1906
rs1485764301,2
C--207037750(+) TGTGC-/ATATATA 1 -- us2k10--------
rs1890502731,2
--207037759(+) ATATAC/TATGAT 1 -- us2k10--------
rs1457471811,2
--207037789(+) TCTTTA/TTAAAT 1 -- us2k10--------
rs1815484251,2
--207037831(+) AGTATC/TTGAGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IL20 (207038699 - 207042568 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IL20:    About this table    
Variant IDTypeSubtypePubMed ID
esv2660993CNV Deletion23128226

Human Gene Mutation Database (HGMD): IL20
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IL20
DNA2.0 Custom Variant and Variant Library Synthesis for IL20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605619    OMIM disorders: --

2 diseases for IL20:    
About MalaCards
psoriasis    spondyloarthropathy


Find genes that share disorders with IL20           About GenesLikeMe

8 Novoseek inferred disease relationships for IL20 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 74.8 29 16645593 (4), 15889129 (4), 19330474 (3), 16225599 (3) (see all 16)
skin lesion 33.3 2 16225599 (1), 19731362 (1)
inflammation 32.8 6 12667095 (3), 17263806 (1), 16645593 (1), 12635355 (1)
melanoma 13.6 4 12370360 (1), 15557163 (1), 11564763 (1), 11929132 (1)
necrosis 0 1 19054079 (1)
tumors 0 2 16731153 (1), 12351624 (1)
cancer 0 2 17255956 (1)
hyperplasia 0 2 16645593 (1)

Genetic Association Database (GAD): IL20
Human Genome Epidemiology (HuGE) Navigator: IL20 (14 documents)

Export disorders for IL20 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IL20 gene, integrated from 10 sources (see all 99):
(articles sorted by number of sources associating them with IL20)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PubMed id 11163236)1, 2, 3 Blumberg H.... Chandrasekher Y.A. (Cell 2001)
  2. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PubMed id 17263806)1, 4, 9 Kingo K....Silm H. (Br. J. Dermatol. 2007)
  3. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PubMed id 19087313)1, 4, 9 Traks T....KA/ks S. (BMC Med. Genet. 2008)
  4. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PubMed id 15815689)1, 4, 9 Oleksyk T.K....Smith M.W. (Genes Immun. 2005)
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  6. Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents. (PubMed id 20976276)1, 4 Shrestha S....Tang J. (PLoS ONE 2010)
  7. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  9. Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome. (PubMed id 18479293)1, 4 Truelove A.L....Smith M.W. (Int. J. Immunogenet. 2008)
  10. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 50604 HGNC: 6002 AceView: IL20 Ensembl:ENSG00000162891 euGenes: HUgn50604
ECgene: IL20 Kegg: 50604 H-InvDB: IL20

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL20 Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/il20/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL20 gene:
Search GeneIP for patents involving IL20

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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