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Aliases for IL20 Gene

Aliases for IL20 Gene

  • Interleukin 20 2 3 5
  • Cytokine Zcyto10 3 4
  • ZCYTO10 3 4
  • IL-20 3 4
  • Four Alpha Helix Cytokine 3
  • Interleukin-20 3
  • IL10D 3

External Ids for IL20 Gene

Previous GeneCards Identifiers for IL20 Gene

  • GC01P205699
  • GC01P202749
  • GC01P203682
  • GC01P204122
  • GC01P203427
  • GC01P205105
  • GC01P207038
  • GC01P177737

Summaries for IL20 Gene

Entrez Gene Summary for IL20 Gene

  • The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL20 Gene

IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include Psoriasis. Among its related pathways are PEDF Induced Signaling and Innate Immune System. GO annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot for IL20 Gene

  • Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL20 Gene

Genomics for IL20 Gene

Regulatory Elements for IL20 Gene

Enhancers for IL20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G206917 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 +57.7 57717 12.0 HDGF PKNOX1 ARNT WRNIP1 SIN3A YBX1 ZNF2 ZBTB7B YY1 ZNF766 MAPKAPK2 ENSG00000271680 CDCA4P4 PIGR FCAMR IL20 IL19 FCMR IKBKE RASSF5
GH01G207017 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +161.3 161315 18.4 CREB3L1 MLX YBX1 SP3 NFYC MEF2D NBN NR2C1 KDM1A WT1 C4BPA C4BPB FCAMR PIGR FCMR IL20 PFKFB2 C1orf116 GC01P207018
GH01G206768 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10 -94.4 -94430 4.6 HDGF PKNOX1 ATF1 YY1 TCF12 GATA2 ZNF143 JUNB TBX21 KAT8 IL19 MAPKAPK2 IL24 IL20 IL10 C4BPB RASSF5 ENSG00000284486
GH01G206904 1.5 FANTOM5 ENCODE dbSUPER 11.3 +40.7 40703 3.3 ATF1 PKNOX1 ARNT ARID4B ZNF2 YY1 GATA2 ELK1 ZNF143 ZNF207 ENSG00000271680 IL20 PIGR FCAMR FCMR IL19 RPL13AP8
GH01G206722 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -141.7 -141667 2.2 TBP SIN3A BRCA1 RAD21 RFX5 YY1 RCOR1 FOS ZHX1 DEK MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 GC01P206699
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL20 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL20 Gene

Chromosome:
1
Start:
206,865,354 bp from pter
End:
206,869,223 bp from pter
Size:
3,870 bases
Orientation:
Plus strand

Genomic View for IL20 Gene

Genes around IL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20 Gene

Proteins for IL20 Gene

  • Protein details for IL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYY1-IL20_HUMAN
    Recommended name:
    Interleukin-20
    Protein Accession:
    Q9NYY1
    Secondary Accessions:
    • Q17RB3
    • Q2THG6
    • Q96QZ6

    Protein attributes for IL20 Gene

    Size:
    176 amino acids
    Molecular mass:
    20072 Da
    Quaternary structure:
    • Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.

    Three dimensional structures from OCA and Proteopedia for IL20 Gene

    Alternative splice isoforms for IL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20 Gene

Post-translational modifications for IL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL20 Gene

Assay Products

No data available for DME Specific Peptides for IL20 Gene

Domains & Families for IL20 Gene

Gene Families for IL20 Gene

Suggested Antigen Peptide Sequences for IL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYY1

UniProtKB/Swiss-Prot:

IL20_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL20: view

Function for IL20 Gene

Molecular function for IL20 Gene

UniProtKB/Swiss-Prot Function:
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV-B irradiation in epithelial keratinocytes.

Gene Ontology (GO) - Molecular Function for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0045517 interleukin-20 receptor binding TAS 11470428
GO:0045518 interleukin-22 receptor binding IEA --
genes like me logo Genes that share ontologies with IL20: view

Phenotypes for IL20 Gene

genes like me logo Genes that share phenotypes with IL20: view

Animal Models for IL20 Gene

MGI Knock Outs for IL20:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL20

CRISPR Products

miRNA for IL20 Gene

miRTarBase miRNAs that target IL20

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL20 Gene

Localization for IL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL20 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 11470428
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL20: view

Pathways & Interactions for IL20 Gene

genes like me logo Genes that share pathways with IL20: view

SIGNOR curated interactions for IL20 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein TAS --
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS 11470428
GO:0045606 positive regulation of epidermal cell differentiation TAS 11470428
GO:0045618 positive regulation of keratinocyte differentiation TAS 11470428
GO:0045672 positive regulation of osteoclast differentiation IEA --
genes like me logo Genes that share ontologies with IL20: view

Drugs & Compounds for IL20 Gene

(1) Drugs for IL20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL20: view

Transcripts for IL20 Gene

mRNA/cDNA for IL20 Gene

(2) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL20 Gene

Interleukin 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL20

Alternative Splicing Database (ASD) splice patterns (SP) for IL20 Gene

No ASD Table

Relevant External Links for IL20 Gene

GeneLoc Exon Structure for
IL20
ECgene alternative splicing isoforms for
IL20

Expression for IL20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL20 Gene

mRNA differential expression in normal tissues according to GTEx for IL20 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x12.3), Adipose - Visceral (Omentum) (x9.9), and Skin - Sun Exposed (Lower leg) (x5.4).

Protein differential expression in normal tissues from HIPED for IL20 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL20 Gene



Protein tissue co-expression partners for IL20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL20 Gene:

IL20

SOURCE GeneReport for Unigene cluster for IL20 Gene:

Hs.272373

mRNA Expression by UniProt/SwissProt for IL20 Gene:

Q9NYY1-IL20_HUMAN
Tissue specificity: Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.
genes like me logo Genes that share expression patterns with IL20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL20 Gene

Orthologs for IL20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL20 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia IL20 34 35
  • 87.88 (n)
cow
(Bos Taurus)
Mammalia IL20 34 35
  • 83.9 (n)
mouse
(Mus musculus)
Mammalia Il20 34 16 35
  • 82.38 (n)
rat
(Rattus norvegicus)
Mammalia Il20 34
  • 80.46 (n)
oppossum
(Monodelphis domestica)
Mammalia IL20 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL20 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL19 34
  • 54.67 (n)
zebrafish
(Danio rerio)
Actinopterygii il34 34
  • 52.63 (n)
il19l 35
  • 36 (a)
OneToMany
Species where no ortholog for IL20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL20 Gene

ENSEMBL:
Gene Tree for IL20 (if available)
TreeFam:
Gene Tree for IL20 (if available)

Paralogs for IL20 Gene

Paralogs for IL20 Gene

(2) SIMAP similar genes for IL20 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL20: view

Variants for IL20 Gene

Sequence variations from dbSNP and Humsavar for IL20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000506836 -- 206,866,166(+) AGTTC(A/G)AATAT intron-variant
rs1000558800 -- 206,865,752(+) CCCCC(A/C/T)ACCCC intron-variant, upstream-variant-2KB
rs1001140710 -- 206,864,822(+) TTTTT(A/T)TCTTG upstream-variant-2KB
rs1001443226 -- 206,865,229(+) CCTCT(-/G)GGGCT upstream-variant-2KB
rs1002003744 -- 206,866,788(+) TAATA(A/G)GAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL20 Gene

Variant ID Type Subtype PubMed ID
esv2660993 CNV deletion 23128226
esv3588662 CNV loss 21293372
nsv549070 CNV loss 21841781

Variation tolerance for IL20 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL20 Gene

Human Gene Mutation Database (HGMD)
IL20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20 Gene

Disorders for IL20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL20 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search IL20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL20

Genetic Association Database (GAD)
IL20
Human Genome Epidemiology (HuGE) Navigator
IL20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL20
genes like me logo Genes that share disorders with IL20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL20 Gene

Publications for IL20 Gene

  1. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T. … KA/ks S. (BMC Med. Genet. 2008) 3 22 46 64
  2. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K. … Silm H. (Br. J. Dermatol. 2007) 3 22 46 64
  3. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PMID: 15815689) Oleksyk T.K. … Smith M.W. (Genes Immun. 2005) 3 22 46 64
  4. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H. … Chandrasekher Y.A. (Cell 2001) 2 3 4 64
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64

Products for IL20 Gene

Sources for IL20 Gene

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