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Aliases for IL20 Gene

Aliases for IL20 Gene

  • Interleukin 20 2 3 5
  • Cytokine Zcyto10 3 4
  • ZCYTO10 3 4
  • IL-20 3 4
  • Four Alpha Helix Cytokine 3
  • IL10D 3

External Ids for IL20 Gene

Previous GeneCards Identifiers for IL20 Gene

  • GC01P205699
  • GC01P202749
  • GC01P203682
  • GC01P204122
  • GC01P203427
  • GC01P205105
  • GC01P207038
  • GC01P177737

Summaries for IL20 Gene

Entrez Gene Summary for IL20 Gene

  • The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL20 Gene

IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include psoriasis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL24.

UniProtKB/Swiss-Prot for IL20 Gene

  • Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL20 Gene

Genomics for IL20 Gene

Regulatory Elements for IL20 Gene

Genomic Location for IL20 Gene

Chromosome:
1
Start:
206,865,354 bp from pter
End:
206,869,223 bp from pter
Size:
3,870 bases
Orientation:
Plus strand

Genomic View for IL20 Gene

Genes around IL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20 Gene

Proteins for IL20 Gene

  • Protein details for IL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYY1-IL20_HUMAN
    Recommended name:
    Interleukin-20
    Protein Accession:
    Q9NYY1
    Secondary Accessions:
    • Q17RB3
    • Q2THG6
    • Q96QZ6

    Protein attributes for IL20 Gene

    Size:
    176 amino acids
    Molecular mass:
    20072 Da
    Quaternary structure:
    • Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.

    Three dimensional structures from OCA and Proteopedia for IL20 Gene

    Alternative splice isoforms for IL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20 Gene

Proteomics data for IL20 Gene at MOPED

Post-translational modifications for IL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL20 Gene

Domains & Families for IL20 Gene

Gene Families for IL20 Gene

Suggested Antigen Peptide Sequences for IL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYY1

UniProtKB/Swiss-Prot:

IL20_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL20: view

Function for IL20 Gene

Molecular function for IL20 Gene

UniProtKB/Swiss-Prot Function:
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV-B irradiation in epithelial keratinocytes.

Gene Ontology (GO) - Molecular Function for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
genes like me logo Genes that share ontologies with IL20: view

Phenotypes for IL20 Gene

genes like me logo Genes that share phenotypes with IL20: view

Animal Model Products

miRNA for IL20 Gene

miRTarBase miRNAs that target IL20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL20 Gene

Localization for IL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL20 Gene COMPARTMENTS Subcellular localization image for IL20 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for IL20 Gene

Pathways & Interactions for IL20 Gene

genes like me logo Genes that share pathways with IL20: view

SIGNOR curated interactions for IL20 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0045606 positive regulation of epidermal cell differentiation TAS 11470428
GO:0045618 positive regulation of keratinocyte differentiation TAS 11470428
genes like me logo Genes that share ontologies with IL20: view

Drugs & Compounds for IL20 Gene

(1) Drugs for IL20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL20: view

Transcripts for IL20 Gene

mRNA/cDNA for IL20 Gene

(2) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL20 Gene

Interleukin 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL20 Gene

No ASD Table

Relevant External Links for IL20 Gene

GeneLoc Exon Structure for
IL20
ECgene alternative splicing isoforms for
IL20

Expression for IL20 Gene

mRNA expression in normal human tissues for IL20 Gene

mRNA differential expression in normal tissues according to GTEx for IL20 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x12.3), Adipose - Visceral (Omentum) (x9.9), and Skin - Sun Exposed (Lower leg) (x5.4).

Protein differential expression in normal tissues from HIPED for IL20 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL20 Gene



SOURCE GeneReport for Unigene cluster for IL20 Gene Hs.272373

mRNA Expression by UniProt/SwissProt for IL20 Gene

Q9NYY1-IL20_HUMAN
Tissue specificity: Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.
genes like me logo Genes that share expression patterns with IL20: view

Protein tissue co-expression partners for IL20 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL20 Gene

Orthologs for IL20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL20 35
  • 83.9 (n)
  • 76.7 (a)
IL20 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL20 35
  • 87.88 (n)
  • 85.8 (a)
IL20 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il20 35
  • 82.38 (n)
  • 75.86 (a)
Il20 16
Il20 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL20 35
  • 99.62 (n)
  • 100 (a)
IL20 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il20 35
  • 80.46 (n)
  • 74.71 (a)
oppossum
(Monodelphis domestica)
Mammalia IL20 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL20 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL19 35
  • 54.67 (n)
  • 41.14 (a)
zebrafish
(Danio rerio)
Actinopterygii il34 35
  • 52.63 (n)
  • 43.42 (a)
il19l 36
  • 36 (a)
OneToMany
Species with no ortholog for IL20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL20 Gene

ENSEMBL:
Gene Tree for IL20 (if available)
TreeFam:
Gene Tree for IL20 (if available)

Paralogs for IL20 Gene

Paralogs for IL20 Gene

(2) SIMAP similar genes for IL20 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL20: view

Variants for IL20 Gene

Sequence variations from dbSNP and Humsavar for IL20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35856950 - 206,866,578(-) TCTTC(C/T)GGAGA reference, missense
rs1109461 -- 206,868,458(-) GGTTA(A/G)CAATT intron-variant
rs1400986 -- 206,865,341(+) TTCCC(C/T)CTAGG upstream-variant-2KB
rs1713239 -- 206,864,130(-) CCCAG(C/G)ACTGA upstream-variant-2KB
rs2232356 -- 206,865,796(+) AGTAA(A/G)TCATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL20 Gene

Variant ID Type Subtype PubMed ID
esv2660993 CNV Deletion 23128226

Variation tolerance for IL20 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL20 Gene

HapMap Linkage Disequilibrium report
IL20
Human Gene Mutation Database (HGMD)
IL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20 Gene

Disorders for IL20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL20 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search IL20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL20

Genetic Association Database (GAD)
IL20
Human Genome Epidemiology (HuGE) Navigator
IL20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL20
genes like me logo Genes that share disorders with IL20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL20 Gene

Publications for IL20 Gene

  1. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H. … Chandrasekher Y.A. (Cell 2001) 2 3 4 67
  2. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. (PMID: 19342680) Chen W.Y. … Chang M.S. (J. Immunol. 2009) 3 23
  3. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. (PMID: 19830738) Wolk K. … Sabat R. (Eur. J. Immunol. 2009) 3 23
  4. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T. … KA/ks S. (BMC Med. Genet. 2008) 3 23
  5. IL-20 gene expression is induced by IL-1beta through mitogen-activated protein kinase and NF-kappaB-dependent mechanisms. (PMID: 17255956) Otkjaer K. … Iversen L. (J. Invest. Dermatol. 2007) 3 23

Products for IL20 Gene

Sources for IL20 Gene

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