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Aliases for IL2 Gene

Aliases for IL2 Gene

  • Interleukin 2 2 3
  • T Cell Growth Factor 2 3
  • Aldesleukin 3 4
  • IL-2 3 4
  • TCGF 3 4
  • Involved In Regulation Of T-Cell Clonal Expansion 3
  • T-Cell Growth Factor 4
  • Interleukin-2 3
  • Lymphokine 3

External Ids for IL2 Gene

Summaries for IL2 Gene

Entrez Gene Summary for IL2 Gene

  • The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL2 Gene

IL2 (Interleukin 2) is a Protein Coding gene. Diseases associated with IL2 include colitis and ulcerative colitis. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and carbohydrate binding.

UniProtKB/Swiss-Prot for IL2 Gene

  • Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells

Tocris Summary for IL2 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL2 Gene

Genomics for IL2 Gene

Genomic Location for IL2 Gene

Start:
122,451,470 bp from pter
End:
122,456,725 bp from pter
Size:
5,256 bases
Orientation:
Minus strand

Genomic View for IL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL2 Gene

Regulatory Elements for IL2 Gene

Transcription factor binding sites by QIAGEN in the IL2 gene promoter:

Proteins for IL2 Gene

  • Protein details for IL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60568-IL2_HUMAN
    Recommended name:
    Interleukin-2
    Protein Accession:
    P60568
    Secondary Accessions:
    • P01585

    Protein attributes for IL2 Gene

    Size:
    153 amino acids
    Molecular mass:
    17628 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA59140.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL2 Gene

neXtProt entry for IL2 Gene

Proteomics data for IL2 Gene at MOPED

Post-translational modifications for IL2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr23

Other Protein References for IL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IL2 Gene

Domains for IL2 Gene

Gene Families for IL2 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL2 Gene

Suggested Antigen Peptide Sequences for IL2 Gene

Graphical View of Domain Structure for InterPro Entry

P60568

UniProtKB/Swiss-Prot:

IL2_HUMAN
Family:
  • Belongs to the IL-2 family.:
    • P60568
genes like me logo Genes that share domains with IL2: view

Function for IL2 Gene

Molecular function for IL2 Gene

GENATLAS Biochemistry: interleukin 2,30-35kDa,involved in activation and proliferation of T cell
UniProtKB/Swiss-Prot Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells

Gene Ontology (GO) - Molecular Function for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 10072077
GO:0005134 interleukin-2 receptor binding TAS 3925347
GO:0008083 growth factor activity TAS 8476561
GO:0019209 kinase activator activity TAS 8476561
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with IL2: view
genes like me logo Genes that share phenotypes with IL2: view

Animal Models for IL2 Gene

MGI Knock Outs for IL2:

miRNA for IL2 Gene

miRTarBase miRNAs that target IL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL2 Gene

Localization for IL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL2 Gene COMPARTMENTS Subcellular localization image for IL2 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytoskeleton 2
cytosol 2
lysosome 2
mitochondrion 2
vacuole 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 6608729
genes like me logo Genes that share ontologies with IL2: view

Pathways for IL2 Gene

SuperPathways for IL2 Gene

genes like me logo Genes that share pathways with IL2: view

Gene Ontology (GO) - Biological Process for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0001934 positive regulation of protein phosphorylation --
GO:0002903 negative regulation of B cell apoptotic process IDA 9184696
GO:0006955 immune response TAS 2342538
GO:0007155 cell adhesion TAS 10929056
genes like me logo Genes that share ontologies with IL2: view

Compounds for IL2 Gene

UniProtKB/Swiss-Prot:

P60568-IL2_HUMAN
Pharmaceutical: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma

(5) Tocris Compounds for IL2 Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines [6501-72-0]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(125) Novoseek inferred chemical compound relationships for IL2 Gene

Compound -log(P) Hits PubMed IDs
ionomycin 82.7 144
proleukin 82 42
okt3 80.1 158
dacarbazine 75.1 118
cyclosporin a 74.5 207
genes like me logo Genes that share compounds with IL2: view

Transcripts for IL2 Gene

mRNA/cDNA for IL2 Gene

(1) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL2 Gene

Interleukin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for IL2 Gene

GeneLoc Exon Structure for
IL2
ECgene alternative splicing isoforms for
IL2

Expression for IL2 Gene

mRNA expression in normal human tissues for IL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (9.9) and Bladder (4.9).

SOURCE GeneReport for Unigene cluster for IL2 Gene Hs.89679

genes like me logo Genes that share expressions with IL2: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for IL2 Gene

Orthologs for IL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL2 35
  • 100 (n)
  • 100 (a)
IL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL2 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL2 35
  • 86.93 (n)
  • 75.16 (a)
IL2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il2 35
  • 69.98 (n)
  • 58.94 (a)
Il2 16
Il2 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il2 35
  • 76.25 (n)
  • 66.67 (a)
Species with no ortholog for IL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL2 Gene

ENSEMBL:
Gene Tree for IL2 (if available)
TreeFam:
Gene Tree for IL2 (if available)

Paralogs for IL2 Gene

Selected SIMAP similar genes for IL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IL2: view

No data available for Paralogs for IL2 Gene

Variants for IL2 Gene

Sequence variations from dbSNP and Humsavar for IL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1051753 -- 122,451,758(-) ACACT(A/G)ACTTG synonymous-codon, reference
rs1479920 -- 122,454,455(-) ATAAT(C/T)TTTTA intron-variant
rs1479921 -- 122,453,390(-) TTTTA(C/T)TATAT intron-variant
rs2067006 -- 122,456,916(-) TGTTT(A/T)ATCAA upstream-variant-2KB
rs2069760 -- 122,457,072(-) AAACA(A/G)TACCT upstream-variant-2KB

Relevant External Links for IL2 Gene

HapMap Linkage Disequilibrium report
IL2
Human Gene Mutation Database (HGMD)
IL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL2 Gene

Disorders for IL2 Gene

UniProtKB/Swiss-Prot

IL2_HUMAN
  • Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

(95) Novoseek inferred disease relationships for IL2 Gene

Disease -log(P) Hits PubMed IDs
metastatic renal cell carcinoma 89.6 219
necrosis 85.5 225
metastatic melanoma 84.3 211
carcinoma renal cell 82.7 239
tumors 82.2 408

Genatlas disease for IL2 Gene

immunodeficiency,severe,combined

Relevant External Links for IL2

Genetic Association Database (GAD)
IL2
Human Genome Epidemiology (HuGE) Navigator
IL2
Tumor Gene Database (TGDB):
IL2
genes like me logo Genes that share disorders with IL2: view

Publications for IL2 Gene

  1. Allelic expression and interleukin-2 polymorphisms in multiple sclerosis. (PMID: 11525806) Matesanz F. … Alcina A. (J. Neuroimmunol. 2001) 3 23 48
  2. An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosis. (PMID: 12409183) Kikuchi S. … Tashiro K. (J. Neurol. Sci. 2002) 3 23 48
  3. Association of IL2, TNFA, IL4 and IL10 Promoter Gene Polymorphisms with the Rate of Progression of the HIV Infection. (PMID: 12687247) Smolnikova M.V. … Konenkov V.I. (Russ. J. Immunol. 2002) 3 23 48
  4. Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression. (PMID: 12944981) Vasilescu A. … Zagury J.F. (Genes Immun. 2003) 3 23 48
  5. Analysis of -631 and -475 interleukin-2 promoter single nucleotide polymorphisms in multiple sclerosis. (PMID: 12358847) Fedetz M. … Matesanz F. (Eur. J. Immunogenet. 2002) 3 23 48

Products for IL2 Gene

  • Addgene plasmids for IL2

Sources for IL2 Gene

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