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Aliases for IL2 Gene

Aliases for IL2 Gene

  • Interleukin 2 2 3 5
  • T Cell Growth Factor 2 3
  • Aldesleukin 3 4
  • IL-2 3 4
  • TCGF 3 4
  • Involved In Regulation Of T-Cell Clonal Expansion 3
  • T-Cell Growth Factor 4
  • Lymphokine 3

External Ids for IL2 Gene

Previous GeneCards Identifiers for IL2 Gene

  • GC04M124285
  • GC04M123652
  • GC04M123765
  • GC04M123831
  • GC04M123730
  • GC04M123592
  • GC04M123372
  • GC04M119099

Summaries for IL2 Gene

Entrez Gene Summary for IL2 Gene

  • The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL2 Gene

IL2 (Interleukin 2) is a Protein Coding gene. Diseases associated with IL2 include kidney cancer and capillary leak syndrome. Among its related pathways are Allograft rejection and Toll-like receptor signaling pathway. GO annotations related to this gene include carbohydrate binding and growth factor activity.

UniProtKB/Swiss-Prot for IL2 Gene

  • Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Tocris Summary for IL2 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL2 Gene

Genomics for IL2 Gene

Regulatory Elements for IL2 Gene

Enhancers for IL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL2 on UCSC Golden Path with GeneCards custom track

Promoters for IL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL2 gene promoter:

Genomic Location for IL2 Gene

Chromosome:
4
Start:
122,451,470 bp from pter
End:
122,456,725 bp from pter
Size:
5,256 bases
Orientation:
Minus strand

Genomic View for IL2 Gene

Genes around IL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL2 Gene

Proteins for IL2 Gene

  • Protein details for IL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60568-IL2_HUMAN
    Recommended name:
    Interleukin-2
    Protein Accession:
    P60568
    Secondary Accessions:
    • P01585

    Protein attributes for IL2 Gene

    Size:
    153 amino acids
    Molecular mass:
    17628 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA59140.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL2 Gene

neXtProt entry for IL2 Gene

Proteomics data for IL2 Gene at MOPED

Post-translational modifications for IL2 Gene

  • Glycosylation at Thr 23
  • Modification sites at PhosphoSitePlus

Other Protein References for IL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL2 (IL2)

No data available for DME Specific Peptides for IL2 Gene

Domains & Families for IL2 Gene

Gene Families for IL2 Gene

Protein Domains for IL2 Gene

Suggested Antigen Peptide Sequences for IL2 Gene

Graphical View of Domain Structure for InterPro Entry

P60568

UniProtKB/Swiss-Prot:

IL2_HUMAN :
  • Belongs to the IL-2 family.
Family:
  • Belongs to the IL-2 family.
genes like me logo Genes that share domains with IL2: view

Function for IL2 Gene

Molecular function for IL2 Gene

GENATLAS Biochemistry:
interleukin 2,30-35kDa,involved in activation and proliferation of T cell
UniProtKB/Swiss-Prot Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Gene Ontology (GO) - Molecular Function for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019209 kinase activator activity TAS 8476561
GO:0031851 kappa-type opioid receptor binding IEA --
genes like me logo Genes that share ontologies with IL2: view
genes like me logo Genes that share phenotypes with IL2: view

Animal Models for IL2 Gene

MGI Knock Outs for IL2:

Animal Model Products

miRNA for IL2 Gene

miRTarBase miRNAs that target IL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL2 Gene

Localization for IL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL2 Gene COMPARTMENTS Subcellular localization image for IL2 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 3
cytoskeleton 2
lysosome 2
mitochondrion 2
vacuole 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for IL2 Gene

Pathways & Interactions for IL2 Gene

SuperPathways for IL2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 PEDF Induced Signaling
4 Allograft rejection
5 GPCR Pathway
genes like me logo Genes that share pathways with IL2: view

Pathways by source for IL2 Gene

SIGNOR curated interactions for IL2 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IL2: view

Drugs & Compounds for IL2 Gene

(112) Drugs for IL2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dacarbazine Approved, Investigational Pharma 648
rituximab Approved Pharma Therapeutic Antibodies 1593
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1043
Pseudoephedrine Approved Pharma Target 548
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1649

(48) Additional Compounds for IL2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
10Z-Hymenialdisine
82005-12-7
Chicago Sky Blue 6B
2610-05-1

(5) Tocris Compounds for IL2 Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
Chicago Sky Blue 6B Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF 2610-05-1
Gabexate mesylate Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin 56974-61-9
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1
genes like me logo Genes that share compounds with IL2: view

Transcripts for IL2 Gene

mRNA/cDNA for IL2 Gene

(1) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL2 Gene

Interleukin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for IL2 Gene

GeneLoc Exon Structure for
IL2
ECgene alternative splicing isoforms for
IL2

Expression for IL2 Gene

mRNA expression in normal human tissues for IL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x9.9) and Bladder (x4.9).

SOURCE GeneReport for Unigene cluster for IL2 Gene Hs.89679

genes like me logo Genes that share expression patterns with IL2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IL2 Gene

Orthologs for IL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IL2 35
  • 86.93 (n)
  • 75.16 (a)
IL2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il2 35
  • 69.98 (n)
  • 58.94 (a)
Il2 16
Il2 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL2 35
  • 100 (n)
  • 100 (a)
IL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il2 35
  • 76.25 (n)
  • 66.67 (a)
cow
(Bos Taurus)
Mammalia IL2 36
  • 64 (a)
OneToOne
Species with no ortholog for IL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL2 Gene

ENSEMBL:
Gene Tree for IL2 (if available)
TreeFam:
Gene Tree for IL2 (if available)

Paralogs for IL2 Gene

(1) SIMAP similar genes for IL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IL2: view

No data available for Paralogs for IL2 Gene

Variants for IL2 Gene

Sequence variations from dbSNP and Humsavar for IL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1051753 -- 122,451,758(-) ACACT(A/G)ACTTG reference, synonymous-codon
rs1479920 -- 122,454,455(-) ATAAT(C/T)TTTTA intron-variant
rs1479921 -- 122,453,390(-) TTTTA(C/T)TATAT intron-variant
rs2067006 -- 122,456,916(-) TGTTT(A/T)ATCAA upstream-variant-2KB
rs2069760 -- 122,457,072(-) AAACA(A/G)TACCT upstream-variant-2KB

Variation tolerance for IL2 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL2 Gene

HapMap Linkage Disequilibrium report
IL2
Human Gene Mutation Database (HGMD)
IL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL2 Gene

Disorders for IL2 Gene

MalaCards: The human disease database

(135) MalaCards diseases for IL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kidney cancer
  • renal cell carcinoma
capillary leak syndrome
farmer's lung
  • farmer lung
tropical spastic paraparesis
  • htlv-associated myelopathy
balanoposthitis
  • balanoposthitis of animal
- elite association - COSMIC cancer census association via MalaCards
Search IL2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL2_HUMAN
  • Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. {ECO:0000269 PubMed:1396583}.

Genatlas disease for IL2 Gene

immunodeficiency,severe,combined

Relevant External Links for IL2

Genetic Association Database (GAD)
IL2
Human Genome Epidemiology (HuGE) Navigator
IL2
Tumor Gene Database (TGDB):
IL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL2
genes like me logo Genes that share disorders with IL2: view

Publications for IL2 Gene

  1. Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PMID: 12727483) Holweg C.T. … Baan C.C. (Transpl. Immunol. 2003) 3 48 67
  2. Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2). (PMID: 20225066) Czystowska M. … Whiteside T.L. (J. Mol. Med. 2010) 3 23
  3. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. (PMID: 19364969) Sabatino M. … Kaufman H.L. (J. Clin. Oncol. 2009) 3 23
  4. IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance. (PMID: 18776133) Goleva E. … Leung D.Y. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23
  5. Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population. (PMID: 17257312) Kaur G. … Mehra N.K. (Tissue Antigens 2007) 3 23

Products for IL2 Gene

Sources for IL2 Gene

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