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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL2 Gene

protein-coding GIFtS: 70
GCID: GC04M123372

interleukin 2

Explore 406 diseases affiliated with
IL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 2¹ ²		Involved In Regulation Of T-Cell Clonal Expansion²
IL-2¹ ² ³		Lymphokine¹
TCGF¹ ² ³		T Cell Growth Factor²
Aldesleukin³		Aldesleukin³
Interleukin-2¹		T-Cell Growth Factor³

External Ids:	HGNC: 6001¹	Entrez Gene: 3558²	Ensembl: ENSG00000109471⁷	OMIM: 147680⁵	UniProtKB: P60568³

ORGUL members:
	NONCODE:n340213

Export aliases for IL2 gene to outside databases

Previous GC identifers: GC04M124285 GC04M123652 GC04M123765 GC04M123831 GC04M123730 GC04M123592 GC04M119099

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL2:

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes.

The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4

(IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an

unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar

gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune

response to antigenic stimuli. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell

proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes,

lymphokine-activated killer cells, natural killer cells, and glioma cells

summary for IL2:

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They

control many different cellular functions including proliferation, differentiation and cell

survival/apoptosis but are also involved in several pathophysiological processes including viral infections

and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the

innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can

be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,

IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.

Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL2 (Interleukin 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL2 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL2 promoter sequence

Search SABiosciences Chromatin IP Primers for IL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26-q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q26-q27

IL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M123372: view genomic region (about GC identifiers)

Start:	123,372,625 bp from pter	End:	123,377,880 bp from pter
Size:	5,256 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568 (See protein sequence)

Recommended Name: Interleukin-2 precursor

Size: 153 amino acids; 17628 Da

Subcellular location: Secreted

Sequence caution: Sequence=AAA59140.1; Type=Erroneous initiation;

6/19 PDB 3D structures from and Proteopedia for IL2 (see all 19):

1ILM (3D)

1ILN (3D)

1IRL (3D)

1M47 (3D)

1M48 (3D)

1M49 (3D)

Secondary accessions: P01585

Explore the universe of human proteins at neXtProt for IL2: NX_P60568

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P60568

IL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000577.2

ENSEMBL proteins:

ENSP00000226730

Reactome Protein details: P60568
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IL2 Protein
	R&D Systems Recombinant & Natural Proteins for IL2 (IL-2)
	Enzo Life Sciences proteins for IL2
	OriGene Purified Protein: IL2 OriGene Protein Over-expression Lysate: IL2 OriGene Custom Protein Services for IL2
	GenScript Purified and Recombinant Proteins for IL2
	Novus Biologicals IL2 Proteins Novus Biologicals IL2 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL2
	Uscn Proteins for IL2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	TAS	6608729

IL2 for ontologies About GeneDecksing

IL2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL2
	R&D Systems Antibodies for IL2 (IL-2)
	Cell Signaling Technology (CST) Antibodies for IL2
	OriGene Antibodies: IL2 OriGene Custom Antibody Services for IL2
	GenScript Superior Antibodies for IL2
	Novus Biologicals IL2 Antibodies
	Abcam antibodies for IL2
	Uscn Antibodies for IL2
	ThermoFisher Antibody for IL2

Assay Products for IL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL2 (IL-2) (see all)
	GenScript Custom Assay Services for IL2
	Cell Signaling Technology (CST) Sandwich ELISA Kits for IL2
	Enzo Life Sciences assays for IL2
	Uscn ELISAs and CLIAs for IL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL2 for domains About GeneDecksing

3 InterPro domains/families:

IPR009079 4_helix_cytokine-like_core

IPR012351 4_helix_cytokine_core

IPR000779 Interleukin-2

Graphical View of Domain Structure for InterPro Entry P60568

ProtoNet protein and cluster: P60568

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Similarity: Belongs to the IL-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell

proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes,

lymphokine-activated killer cells, natural killer cells, and glioma cells

Genatlas biochemistry entry for IL2:

interleukin 2,30-35kDa,involved in activation and proliferation of T cell

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL2
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate IL2 (see all 10):
		hsa-miR-520d-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-3158-3p hsa-miR-186 hsa-miR-524-5p hsa-miR-3121-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL2 (see all 7) OriGene shRNA RFP: IL2 OriGene siRNA: IL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL2 (NM_000586)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL2
		Search LifeMap BioReagents cell lines for IL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	10072077
GO:0005134	interleukin-2 receptor binding	TAS	3925347
GO:0008083	growth factor activity	TAS	8476561
GO:0019209	kinase activator activity	TAS	8476561
GO:0030246	carbohydrate binding	IEA	--

IL2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL2:

Decreased viability of wild-ty

Animal Models:
Mouse knock-out Il2^tm1Hor for IL2
15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Il2) (see all 16):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system
mortality/aging	no phenotypic analysis	other	reproductive system	respiratory system

IL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/49 super-pathways (see all 49) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Interleukin receptor SHC signaling

Interleukin receptor SHC signaling	1.00	SHC1 mediates cytokine-induced phosphorylation of GAB2	0.61
Interleukin-2 signaling	0.67	Interleukin-3, 5 and GM-CSF signaling	0.57
Phosphorylated SHC1 recruits GRB2:GAB2	0.61	Signaling by Interleukins	0.25

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for IL2 (see all 6)

	Immune response CD16 signaling in NK cells
	Immune response Function of MEF2 in T lymphocytes
	Immune response MIF-mediated glucocorticoid regulation
	Immune response IL-22 signaling pathway
	Apoptosis and survival Lymphotoxin-beta receptor signaling

4 R&D Systems Pathways for IL2

	IL-2 Signaling Pathways
	Th1 Differentiation
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/72 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL2 (see all 72)

	Telomerase Components in Cell Signaling
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	JNK Pathway

1 Cell Signaling Technology (CST) Pathway for IL2

Lymphocyte Signaling

3 Tocris Bioscience Pathways for IL2

	Akt Pathway
	Toll-like Receptor Pathway
	MAPK Pathway

5/6 GeneGo (Thomson Reuters) Pathways for IL2 (see all 6)

	Immune response MIF-mediated glucocorticoid regulation
	Immune response IL-22 signaling pathway
	Immune response CD16 signaling in NK cells
	Apoptosis and survival Lymphotoxin-beta receptor signaling
	Immune response Function of MEF2 in T lymphocytes

5/15 BioSystems Pathways for IL2 (see all 15)

	Cytokines and Inflammatory Response
	IL-2 Signaling Pathway
	IL12-mediated signaling events
	Inflammatory Response Pathway
	IL12 signaling mediated by STAT4

5/8 Reactome Pathways for IL2 (see all 8)

	SHC1 mediates cytokine-induced phosphorylation of GAB2
	Interleukin receptor SHC signaling
	Interleukin-2 signaling
	Phosphorylated SHC1 recruits GRB2:GAB2
	Cytokine Signaling in Immune system

1 PharmGKB Pathway for IL2

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

5/10 Kegg Pathways (Kegg details for IL2) (see all 10):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	T cell receptor signaling pathway
	Intestinal immune network for IgA production
	Type I diabetes mellitus

IL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/105 Interacting proteins for IL2 (P60568³ ENSP00000226730⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 105)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IFNA1	P01562³, ENSP00000276927⁴	I2D: score=1 STRING: ENSP00000276927
IL2RB	P14784³, ENSP00000216223⁴	I2D: score=3 STRING: ENSP00000216223
IFNA13	P01562³	I2D: score=1
IL21R	Q9HBE5³, ENSP00000338010⁴	I2D: score=1 STRING: ENSP00000338010
NGFR	P08138³, ENSP00000172229⁴	I2D: score=1 STRING: ENSP00000172229

About this table

Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001933	negative regulation of protein phosphorylation	IEA	--
GO:0001934	positive regulation of protein phosphorylation	--	--
GO:0002903	negative regulation of B cell apoptotic process	IDA	9184696
GO:0006955	immune response	TAS	2342538
GO:0007155	cell adhesion	TAS	10929056

IL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for IL2

Compounds for IL2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Ro 26-4550 trifluoroacetate	Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction	[193744-04-6]

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Pharmaceutical: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic

melanoma

7 DrugBank Compounds for IL2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester	--	--	target	--	17139284 17016423 10592235
2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide	--	--	target	--	17139284 17016423 10592235
5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid	--	--	target	--	17139284 17016423 10592235
SP2456	--	--	target	--	17139284 17016423 10592235
SP4160	--	--	target	--	17139284 17016423 10592235
(1h-Indol-3-Yl)-(2-Mercapto-Ethoxyimino)-Acetic Acid	--	--	target	--	10592235
3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One	--	--	target	--	10592235

10/125 Novoseek chemical compound relationships for IL2 gene (see all 125) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ionomycin	82.7	318	2017664 (5), 9823934 (5), 7539752 (4), 11306241 (4) (see all 99)
proleukin	82	67	11943448 (2), 18646697 (2), 7834457 (1), 12974198 (1) (see all 40)
okt3	80.1	254	8336188 (8), 2160321 (6), 7613643 (6), 8313660 (5) (see all 99)
dacarbazine	75.1	153	7842406 (3), 9935227 (2), 10873069 (2), 2337862 (2) (see all 92)
cyclosporin a	74.5	637	1384862 (6), 10589954 (5), 10760803 (5), 12446480 (5) (see all 99)
il 10	72.6	104	9800291 (3), 11955389 (3), 8901428 (2), 9272647 (2) (see all 82)
r-il-2	71.8	22	1714392 (2), 1873855 (1), 7695972 (1), 14744937 (1) (see all 16)
thymidine	69	225	1974593 (2), 1777232 (2), 8288318 (2), 7949016 (2) (see all 99)
rantes	68.1	140	16644491 (4), 10365778 (3), 9644628 (2), 10369186 (2) (see all 99)
denileukin diftitox	65.9	43	16224276 (3), 15353540 (1), 16516672 (1), 11594570 (1) (see all 24)

Search CenterWatch for drugs/clinical trials and news about IL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL2 gene:

NM_000586.3

Unigene Cluster for IL2:

Interleukin 2

Hs.89679 [show with all ESTs]

Unigene Representative Sequence: S82692

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000226730(uc003ier.3) ENST00000477645

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL2
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate IL2 (see all 10):
		hsa-miR-520d-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-3158-3p hsa-miR-186 hsa-miR-524-5p hsa-miR-3121-3p

		SwitchGear 3'UTR luciferase reporter plasmid: IL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL2 (see all 7) OriGene shRNA RFP: IL2 OriGene siRNA: IL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL2 (NM_000586)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL2

Additional cDNA sequence:

AB451325.1 AB451454.1 AF228636.1 AF532913.1 AY283686.1 AY523040.1 BC066254.1 BC066255.1

BC066256.1 BC066257.1 BC070338.1 DQ231169.1 DQ861285.1 S77834.1 S77835.1 S82692.1

U25676.1 V00564.1 X01586.1

1 DOTS entry:

DT.210021

24/40 AceView cDNA sequences (see all 40):

BC066255 CD559749 CD559748 BC066257 AF532913 X01586 CD013917 AY523040

CD559593 CD559416 CD642113 CD639586 AF228636 CD521264 CD638573 CD638487

S82692 BC070338 CD559590 CD640183 CD640220 CD521982 CD641180 CD520719

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IL2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b
SP1:
SP2:

ECgene alternative splicing isoforms for IL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGAATATG

About this image
See IL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL2

SOURCE GeneReport for Unigene cluster: Hs.89679

SABiosciences Expression via Pathway-Focused PCR Arrays including IL2 (see all 24):

HIV Host Response in human mouse rat

Wound Healing in human mouse rat

Lymphoma in human mouse rat

T-cell & B-cell Activation in human mouse rat

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL2 Browse OriGene validated miRNA SYBR primer pairs
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for IL2 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il2^{1 , 5}	interleukin 2^{1, 5}	72.63(n)¹ 63.58(a)¹		3 (18.30 cM)⁵ 16183¹ NM_008366.3¹ NP_032392.1¹ 37120523⁵

ENSEMBL Gene Tree for IL2 (if available)
TreeFam Gene Tree for IL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Human Gene Mutation Database (HGMD): IL2

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL2 for disorders About GeneDecksing

OMIM gene information: 147680 OMIM disorders: --

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL).

Translocation t(4;16)(q26;p13) with involves TNFRSF17

20/406 diseases for IL2 (see all 406): About MalaCards

htlv-1 associated myelopathy/tropical spastic paraparesis htlv-1 associated myelopathy ulcerative colitis chronic active epstein-barr virus infection

pure red-cell aplasia graft versus host disease tropical spastic paraparesis capillary leak syndrome

severe combined immunodeficiency spinal cord injury relapsing-remitting multiple sclerosis b-cell non-hodgkin lymphoma

churg-strauss syndrome common variable immunodeficiency toxic epidermal necrolysis otitis media

gamma chain deficiency diffuse large b-cell lymphoma subacute sclerosing panencephalitis spastic paraparesis

20/41 diseases from the University of Copenhagen DISEASES database for IL2 (see all 41):

Renal cell carcinoma Melanoma Leukemia Lymphoma

Human immunodeficiency virus infectious disease Hypersensitivity reaction type II disease Carcinoma Rheumatoid arthritis

Severe combined immunodeficiency Diphtheria Leukopenia Skin disease

Tetanus Colorectal cancer Sarcoma Eosinophilia

Connective tissue disease Lung disease Lung cancer Mast cell neoplasm

10/95 Novoseek disease relationships for IL2 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastatic renal cell carcinoma	89.6	629	10685669 (4), 9457403 (4), 7754541 (3), 7490829 (3) (see all 99)
necrosis	85.5	2740	11490833 (7), 2112520 (5), 12710650 (4), 1700673 (4) (see all 99)
metastatic melanoma	84.3	507	9215828 (5), 10091789 (4), 12714884 (4), 17576460 (4) (see all 99)
carcinoma renal cell	82.7	775	20106881 (5), 17264761 (5), 10760767 (4), 10838668 (4) (see all 99)
tumors	82.2	4831	2302724 (7), 11490833 (7), 18256831 (7), 7523315 (7) (see all 99)
melanoma	78.7	1101	11125310 (7), 19509154 (6), 7833372 (5), 16365605 (5) (see all 99)
severe combined immunodeficiency, x-linked	74.1	69	8299698 (3), 7937790 (2), 7930609 (2), 8128231 (1) (see all 35)
renal cancer	73.6	188	2253233 (4), 9166506 (4), 1567700 (4), 7960603 (3) (see all 99)
stable disease	73.1	45	16224275 (2), 8249176 (2), 7754541 (1), 11448899 (1) (see all 33)
autoimmune diseases	71.4	114	1836210 (2), 1976464 (2), 1742421 (2), 12359737 (2) (see all 79)

Genatlas disease: IL2

immunodeficiency,severe,combined

Genetic Association Database (GAD): IL2
Human Genome Epidemiology (HuGE) Navigator: IL2 (248 documents)
Tumor Gene Database (TGDB): IL2

Export disorders for IL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL2 gene, integrated from 9 sources (see all 7002):
(articles sorted by number of sources associating them with IL2)

Utopia: connect your pdf to the dynamic
world of online information

Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PubMed id 12727483)^{1, 4, 9} Holweg C.T....Baan C.C. (2003)
Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection. (PubMed id 15904474)^{1, 4, 9} Togawa S....Hamajima N. (2005)
An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosis. (PubMed id 12409183)^{1, 4, 9} Kikuchi S....Tashiro K. (2002)
Allelic expression and interleukin-2 polymorphisms in multiple sclerosis. (PubMed id 11525806)^{1, 4, 9} Matesanz F....Alcina A. (2001)
Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. (PubMed id 11315919)^{1, 4, 9} Donn R.P....Thomson W. (2001)
Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. (PubMed id 16323127)^{1, 4, 9} Shrestha S....Smith M.W. (2006)
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. (PubMed id 16389181)^{1, 4, 9} Rothman N....Nieters A. (2006)
Family based association analysis of the IL2 and IL15 genes in allergic disorders. (PubMed id 16333313)^{1, 4, 9} Christensen U....Borglum A.D. (2006)
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. (PubMed id 16293754)^{1, 2, 9} Wang X.... Garcia K.C. (2005)
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. (PubMed id 15733644)^{1, 4, 9} Noponen-Hietala N....Ala-Kokko L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3558	HGNC: 6001	AceView: IL2	Ensembl:ENSG00000109471	euGenes: HUgn3558
ECgene: IL2	Kegg: 3558	H-InvDB: IL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL2	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: IL-2	http://www.rndsystems.com/molecule_detail.aspx?m=1638
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_2
SeattleSNPs	http://pga.gs.washington.edu/data/il2/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL2

Intellectual Property for IL2 gene
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Patent Information for IL2 gene:
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GeneCards and IP:
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IL2 Gene

interleukin 2

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