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IL2 Gene

protein-coding GIFtS: 69

GC04M123652

interleukin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Aldesleukin ^³
IL-2 ^¹, ², ³
TCGF ^², ³
aldesleukin ^²
interleukin-2 ^²
lymphokine ^²

Descriptions
T cell growth factor ^²
T-cell growth factor ^³
interleukin 2 ^²
involved in regulation of T-cell clonal expansion ^²

External Ids
HGNC: 6001¹
Entrez Gene: 3558²
UniProtKB: P60568³
Ensembl: ENSG00000109471⁷

Search outside databases for aliases for IL2 gene

Previous GC identifers: GC04M124285 GC04M123765 GC04M123831 GC04M123730

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IL2:

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of

T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma

chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene

in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling

the precise expression of a single gene. The targeted disruption of a similar gene in mice leads

to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune

response to antigenic stimuli. [provided by RefSeq]

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is

required for T-cell proliferation and other activities crucial to regulation of the immune

response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer

cells, and glioma cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IL2 gene

Entrez Gene cytogenetic band: 4q26-q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q26-q27

IL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M123652: (about GC identifiers)

Start:	123,592,075 bp from pter
End:	123,597,100 bp from pter
Size:	5,026 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568 (See protein sequence)

Recommended Name: Interleukin-2 precursor

Size: 153 amino acids; 17628 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1ILM (3D)

1ILN (3D)

1IRL (3D)

1M47 (3D)

1M48 (3D)

1M49 (3D)

1M4A (3D)

1M4B (3D)

1M4C (3D)

1NBP (3D)

1PW6 (3D)

1PY2 (3D)

1QVN (3D)

1Z92 (3D)

2B5I (3D)

2ERJ (3D)

3INK (3D)

Secondary accessions: P01585

REFSEQ proteins: NP_000577.2

ENSEMBL proteins:

ENSP00000226730

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IL2
	Millipore Purified and/or Recombinant IL2 Protein
	Sigma-Aldrich Proteins for IL2
	R&D Systems Recombinant & Natural Proteins for IL2 (IL-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Interferon Gamma + IL2, IL2, IL10 + IL2)
	Human Recombinant Proteins from Abnova (IL2)

OriGene Purified Recombinant Human Protein: IL2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	6608729

About this table

Antibodies for IL2:

	Invitrogen Antibodies for IL2
	Millipore Mono- and Polyclonal Antibodies for the study of IL2
	Sigma-Aldrich Antibodies for IL2
	R&D Systems Antibodies for IL2 (IL-2)
	Antibodies from Abcam (Interferon Gamma + IL2, IL2, IL10 + IL2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for IL2

Assays for IL2:

	Invitrogen Assays for IL2
	Millipore Kits and Assays for the Analysis of IL2
	R&D Systems Flow Cytometry Kits for IL2 (IL-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P60568

ProtoNet protein and cluster: P60568

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Similarity: Belongs to the IL-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000586

Applied Biosystems Silencer® siRNAs for IL2

Sigma-Aldrich siRNA and siRNA Panels for IL2

Sigma-Aldrich shRNA Panels and shRNA for IL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000586
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000586
untagged cDNA clone in CMV expression vector: NM_000586

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000586

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is

required for T-cell proliferation and other activities crucial to regulation of the immune

response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer

cells, and glioma cells

Genatlas biochemistry entry for IL2:

interleukin 2,30-35kDa,involved in activation and proliferation of T cell

15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Il2):

	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging	liver/biliary system
no phenotypic analysis	other	reproductive system	respiratory system	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	10072077
GO:0005134	interleukin-2 receptor binding	TAS	3925347
GO:0005515	protein binding	IEA	--
GO:0019209	kinase activator activity	TAS	8476561

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/12 Sigma-Aldrich "Your Favorite Gene" Pathways for IL2 (Your Favorite Gene powered by Ingenuity) (see all 12 )

IL-2 Signaling
Type I Diabetes Mellitus Signaling
Role of Cytokines in Mediating Communication between Immune Cells
CD28 Signaling in T Helper Cells
Graft-versus-Host Disease Signaling

GeneDecks IL2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IL2

5/389 Interacting proteins for IL2 (ENSP00000226730³) via UniProtKB, MINT, and/or STRING (see all 389 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIR3DX1	ENSP00000221567³	STRING (score=.729) STRING (score=.729)
CD8A	ENSP00000283635³	STRING (score=.999)
FOXP3	ENSP00000365369³	STRING (score=.999)
IFNG	ENSP00000229135³	STRING (score=.999)
IL2RA	ENSP00000369293³	STRING (score=.999)

About this table

5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006916	anti-apoptosis	TAS	8476561
GO:0006955	immune response	TAS	2342538
GO:0007155	cell adhesion	TAS	10929056
GO:0007267	cell-cell signaling	TAS	8476561
GO:0008284	positive regulation of cell proliferation	TAS	8476561

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for IL2:

Antagonist Inhibitor

Compounds for IL2 available from Tocris Bioscience

Compound	Action	CAS number
Suplatast tosylate	Th2 cytokine synthesis inhibitor; antiasthmatic	[94055-76-2]
Ro 26-4550 trifluoroacetate	Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction	[193744-04-6]

About this table

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

Pharmaceutical: Available under the name Proleukin (Chiron). Used in patients with renal cell

carcinoma or metastatic melanoma

10/25 Novoseek chemical compound relationships for IL2 gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ionomycin	82.75	310	2017664 (5), 9823934 (5), 7539752 (4), 11306241 (4) (see all 99)
il 10	72.59	98	9800291 (3), 11955389 (3), 8901428 (2), 9272647 (2) (see all 78)
r-il-2	72.17	22	1714392 (2), 1873855 (1), 7695972 (1), 14744937 (1) (see all 16)
thymidine	68.72	222	1974593 (2), 1777232 (2), 8288318 (2), 7949016 (2) (see all 99)
rantes	67.10	127	16644491 (4), 10365778 (3), 9644628 (2), 10369186 (2) (see all 99)
neopterin	65.78	166	8300696 (6), 15593392 (6), 16864954 (5), 1292506 (5) (see all 72)
tyrosine	63.08	542	1751780 (6), 7903276 (6), 8088325 (5), 2007186 (5) (see all 99)
tdac	62.32	17	7780482 (4), 7537108 (2), 1991997 (2), 1972724 (1) (see all 7)
con a	62.29	105	16055081 (4), 1372137 (4), 8092900 (3), 2054070 (3) (see all 54)
nkh 1	61.65	4	1971303 (1), 7535357 (1), 2319257 (1), 1691221 (1)

About this table

1 PharmGKB drug compound relationship for IL2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	2022743 10920190

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000586

Sigma-Aldrich siRNA and siRNA Panels for IL2

Sigma-Aldrich shRNA Panels and shRNA for IL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000586

REFSEQ mRNAs for IL2 gene:

NM_000586.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000586

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000586
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000586
                                 untagged cDNA clone in CMV expression vector: NM_000586

Additional cDNA sequence:

AB451325.1 AB451454.1 AF228636.1 AF532913.1 AY283686.1 AY523040.1 BC066254.1 BC066255.1

BC066256.1 BC066257.1 BC070338.1 DQ231169.1 DQ861285.1 S77834.1 S77835.1 S82692.1

U25676.1 V00564.1 X01586.1

1 DOTS entry:

DT.210021

24/40 AceView cDNA sequences (see all 40 ):

BC066257 CD559748 CD559749 X01586 BC066255 AF532913 CD013917 S82692

CD638487 BC070338 S77834 CD642113 CD520719 BC066256 BC066254 CD521982

NM_000586 AY523040 CD559408 CD559416 CD521790 CD638573 CD641180 CD521264

highest scoring ESTs for IL2:

S82692 AF228636 AY283686 AY523040 BC066254 BC066255 BC066256 BC066257 BC070338 CD520719

Unigene Cluster for IL2:

Interleukin 2

Hs.89679 [show with all ESTs]

Unigene Representative Sequence: S82692

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for IL2

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for IL2

1 Ensembl transcript including schematic representation:

ENST00000226730

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IL2

¹ / ² / ³

4 probe-sets matching IL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34021_at²^{, 3}	U95-A	1	1.00	1.00	0.85	1.34	S82692	1.00	1.00	1.00	1
1538_s_at²^{, 3}	U95-A	1	1.00	1.00	0.35	1.18	X00695	0.20	1.00	0.72	1
207849_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000586	0.60	1.00	0.82	1
207849_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTGAATATG

SOURCE GeneReport for Unigene cluster: Hs.89679
Expression variation in blood from EXPOLDB for IL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL2¹	--	interleukin 2	87.15(n) 75.16(a)	403989 NM_001003305.1 NP_001003305.1
chimpanzee (Pan troglodytes)	IL2¹	--	interleukin 2	100(n) 100(a)	461472 XM_517425.2 XP_517425.1
cow (Bos taurus)	IL2¹	--	interleukin 2	80.39(n) 66.01(a)	280822 NM_180997.1 NP_851340.1
rat (Rattus norvegicus)	Il2¹	--	interleukin 2	76.03(n) 66.67(a)	116562 NM_053836.1 NP_446288.1
mouse (Mus musculus)	Il2^{1, 5}	3 (19.20 cM)⁵	interleukin 2^{1, 5}	72.63(n)¹ 63.58(a)¹	16183¹ NM_008366.2¹ NP_032392.1¹ AF065914⁵ AF065915⁵ (see all 41)

About this table Species with no ortholog for IL2

ENSEMBL Gene Tree for IL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/62 NCBI SNPs in IL2 are shown (see all 62 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2069774^1,2	C,F,H	123591765(-)	`ACCCTG/ACCCAG`	1	--	ng5¹		13	NS EU EA WA NA	1066
	rs2069762^1,2	C,F,H	123597430(-)	`TTTTAT/GGACAA`	1	--	ng3¹ tfbs³		16	NS EA MN CSAM NA EU WA	2554
--	rs3087209^1,2	C,F,H	123596933(-)	`TTTACG/TKCTGG`	1	L/R	mis¹ ese³		10	NA MN CSAM EA EU WA	860
	rs2067006^1,2	C,F,H	123597521(-)	`TGTTTA/TATCAA`	1	--	ng3¹ tfbs³		18	NS EA NA EU WA MN CSAM	1132
	rs10019970^1,2	F,H	123598041(+)	`TACGGA/TTATAT`	1	--	ng3¹		4	EU EA WA	416
	rs2069775^1,2	H	123591696(-)	`TTCCAT/CTGGGT`	1	--	ng5¹		6	NS EU EA WA	506
	rs2069760^1,2	H	123597677(-)	`AAACAG/ATACCT`	1	--	ng3¹		6	NS EU EA WA	514
--	rs2069763^1,2	C,F	123596932(-)	`TTACKG/TCTGGA`	1	L/L	syn¹ ese³		18	NS EA NA MN CSAM	2614
	rs2069769^1,2	C,F,H	123593774(-)	`TTTAAA/GTGCAC`	1	--	int¹		9	NS NA EU EA WA	654
	rs2069764^1,2	C,F,H	123596831(-)	`TTAATA/TACAAT`	1	--	int¹		11	NS EU EA WA MN CSAM	906

About this table

HapMap Linkage Disequilibrium images for IL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147680

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568

A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic

leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17

10/94 Novoseek disease relationships for IL2 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastatic renal cell carcinoma	89.69	607	10685669 (4), 9457403 (4), 7754541 (3), 7490829 (3) (see all 99)
necrosis	85.49	2589	11490833 (7), 2112520 (5), 12710650 (4), 1700673 (4) (see all 99)
metastatic melanoma	84.19	480	9215828 (5), 10091789 (4), 12714884 (4), 11773161 (4) (see all 99)
carcinoma renal cell	82.74	754	17264761 (5), 7773948 (4), 10760767 (4), 8336188 (4) (see all 99)
tumors	82.16	4637	2302724 (7), 11490833 (7), 18256831 (7), 7523315 (7) (see all 99)
melanoma	78.65	1049	11125310 (7), 7833372 (5), 9166506 (5), 16365605 (5) (see all 99)
severe combined immunodeficiency, x-linked	74.75	69	8299698 (3), 7937790 (2), 7930609 (2), 8128231 (1) (see all 35)
renal cancer	73.58	183	2253233 (4), 9166506 (4), 1567700 (4), 7960603 (3) (see all 99)
stable disease	73.08	44	16224275 (2), 8249176 (2), 7754541 (1), 11448899 (1) (see all 32)
kidney cancer metastatic	70.96	20	17105418 (3), 17105423 (2), 15778577 (2), 19409039 (2) (see all 12)

About this table

Genatlas disease: IL2

immunodeficiency,severe,combined

Human Gene Mutation Database: IL2
Genetic Association Database: IL2
Human Genome Epidemiology Navigator: IL2 (141 documents)
Tumor Gene Database: IL2

(Possibly Related Articles in Doctor's Guide)
About This Section

Synthetic Peptide Vaccine For Melanoma Holds Promise

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/5451 PubMed articles for IL2 gene (see all 5451 ):

Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PubMed id 12727483)^{1, 3, 6} Holweg C.T....Baan C.C. (2003)
Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection. (PubMed id 15904474)^{1, 3, 6} Togawa S....Hamajima N. (2005)
Allelic expression and interleukin-2 polymorphisms in multiple sclerosis. (PubMed id 11525806)^{1, 3, 6} Matesanz F....Alcina A. (2001)
Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. (PubMed id 11315919)^{1, 3, 6} Donn R.P....Thomson W. (2001)
Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. (PubMed id 16323127)^{1, 3, 6} Shrestha S....Smith M.W. (2006)
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. (PubMed id 16389181)^{1, 3, 6} Rothman N....Nieters A. (2006)
Family based association analysis of the IL2 and IL15 genes in allergic disorders. (PubMed id 16333313)^{1, 3, 6} Christensen U....Borglum A.D. (2006)
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. (PubMed id 16293754)^{1, 3, 4} Wang X.... Garcia K.C. (2005)
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. (PubMed id 15733644)^{1, 3, 6} Noponen-Hietala N....Ala-Kokko L. (2005)
Association of polymorphisms in Th1, Th2 cytokine genes with hayfever and atopy in a subsample of EPIC-Heidelberg. (PubMed id 15005726)^{1, 3, 6} Nieters A....Becker N. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3558	HGNC: 6001	AceView: IL2	Ensembl:ENSG00000109471	euGenes: HUgn3558
ECgene: IL2	H-InvDB: IL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IL2	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: IL-2	http://www.rndsystems.com/molecule_detail.aspx?m=1638
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_2
SeattleSNPs	http://pga.gs.washington.edu/data/il2/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL2

Licensable Technologies for IL2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IL2		Antibodies for IL2
	Explore super-pooled esiRNAs		Proteins for IL2
	Lentivirus-delivered shRNAs for IL2		Small molecules for IL2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IL2)
	Search for Antibodies
	Chimera RNAi (IL2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Interferon Gamma + IL2, IL2, IL10 + IL2)
	Antibodies (Interferon Gamma + IL2, IL2, IL10 + IL2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for IL2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IL2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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IL2 Gene at Home site.
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IL2 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for IL2

Summaries
for IL2

Genomic Location
for IL2

Proteins
for IL2

Protein Domains/
Families
for IL2

Gene Function
for IL2

Pathways & Interactions
for IL2

Drugs & Compounds
for IL2

Transcripts
for IL2

Expression
for IL2

Orthologs
for IL2

Paralogs
for IL2

SNPs/Variants
for IL2

Disorders & Mutations
for IL2

Medical News
for IL2

Publications
for IL2

Search for IL2

Genome Databases showing IL2

Other Databases showing IL2

Specialized Databases showing IL2

Licensable Technologies
for IL2

Services
for IL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IL2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor IL2

Summariesfor IL2

Genomic Locationfor IL2

Proteinsfor IL2

Protein Domains/Familiesfor IL2

Gene Functionfor IL2

Pathways & Interactionsfor IL2

Drugs & Compoundsfor IL2

Transcriptsfor IL2

Expression for IL2

Orthologsfor IL2

Paralogsfor IL2

SNPs/Variantsfor IL2

Disorders & Mutationsfor IL2

Medical Newsfor IL2

Publicationsfor IL2

Search for IL2

Genome Databases showing IL2

Other Databases showing IL2

Specialized Databases showing IL2

Licensable Technologiesfor IL2

Servicesfor IL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IL2

Summaries
for IL2

Genomic Location
for IL2

Proteins
for IL2

Protein Domains/
Families
for IL2

Gene Function
for IL2

Pathways & Interactions
for IL2

Drugs & Compounds
for IL2

Transcripts
for IL2

Expression
for IL2

Orthologs
for IL2

Paralogs
for IL2

SNPs/Variants
for IL2

Disorders & Mutations
for IL2

Medical News
for IL2

Publications
for IL2

Licensable Technologies
for IL2

Services
for IL2