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IL2 Gene

protein-coding   GIFtS: 70
GCID: GC04M123372

Interleukin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 21 2     interleukin-22
T Cell Growth Factor1 2     Involved In Regulation Of T-Cell Clonal Expansion2
IL-22 3     lymphokine2
TCGF2 3     Aldesleukin3
aldesleukin2     T-Cell Growth Factor3

External Ids:    HGNC: 60011   Entrez Gene: 35582   Ensembl: ENSG000001094717   OMIM: 1476805   UniProtKB: P605683   

Export aliases for IL2 gene to outside databases

Previous GC identifers: GC04M124285 GC04M123652 GC04M123765 GC04M123831 GC04M123730 GC04M123592 GC04M119099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL2 Gene:
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B
lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared
by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic,
which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted
disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role
of this gene in the immune response to antigenic stimuli. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL2 Gene:
IL2 (interleukin 2) is a protein-coding gene. Diseases associated with IL2 include ulcerative colitis, and balanoposthitis. GO annotations related to this gene include carbohydrate binding and cytokine activity.

UniProtKB/Swiss-Prot: IL2_HUMAN, P60568
Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for
T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells,
monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells

summary for IL2 Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL2 (Interleukin 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL2 promoter sequence
   Search Chromatin IP Primers for IL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26-q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q26-q27

IL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M123372:  view genomic region     (about GC identifiers)

Start:
123,372,625 bp from pter      End:
123,377,880 bp from pter
Size:
5,256 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL2_HUMAN, P60568 (See protein sequence)
Recommended Name: Interleukin-2 precursor  
Size: 153 amino acids; 17628 Da
Sequence caution: Sequence=AAA59140.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for IL2 (see all 19):
1ILM (3D)        1ILN (3D)        1IRL (3D)        1M47 (3D)        1M48 (3D)        1M49 (3D)    
Secondary accessions: P01585

Explore the universe of human proteins at neXtProt for IL2: NX_P60568

Explore proteomics data for IL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr23
  • Modification sites at PhosphoSitePlus

  • See IL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000577.2  
    ENSEMBL proteins: 
     ENSP00000226730  
    Reactome Protein details: P60568

    IL2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL2 Protein
    R&D Systems Recombinant & Natural Proteins for IL2 (IL-2)
    Enzo Life Sciences proteins for IL2
    OriGene Purified Proteins for IL2
    OriGene Protein Over-expression Lysate for IL2
    OriGene MassSpec for IL2
    OriGene Custom Protein Services for IL2
    GenScript Purified and Recombinant Proteins for IL2
    Novus Biologicals IL2 Proteins
    Novus Biologicals IL2 Lysate
    Sino Biological Recombinant Protein for IL2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL2
    Cloud-Clone Corp. Proteins for IL2

    IL2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL2
    R&D Systems Antibodies for IL2 (IL-2)
    Cell Signaling Technology (CST) Antibodies for IL2 
    OriGene Antibodies for IL2
    OriGene Custom Antibody Services for IL2
    Novus Biologicals IL2 Antibodies
    Abcam antibodies for IL2
    Cloud-Clone Corp. Antibodies for IL2
    ThermoFisher Antibody for IL2
    LSBio Antibodies in human, mouse, rat for IL2

    IL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL2
    R&D Systems Flow Cytometry Kits for IL2 (IL-2)         (see all)
    GenScript Custom Assay Services for IL2
    Enzo Life Sciences assays for IL2
    Cloud-Clone Corp. ELISAs for IL2
    Cloud-Clone Corp. CLIAs for IL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR000779 IL-2

    Graphical View of Domain Structure for InterPro Entry P60568

    ProtoNet protein and cluster: P60568

    UniProtKB/Swiss-Prot: IL2_HUMAN, P60568
    Similarity: Belongs to the IL-2 family


    IL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL2_HUMAN, P60568
    Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for
    T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells,
    monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells

         Genatlas biochemistry entry for IL2:
    interleukin 2,30-35kDa,involved in activation and proliferation of T cell

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA10072077
    GO:0005134interleukin-2 receptor binding TAS3925347
    GO:0008083growth factor activity TAS8476561
    GO:0019209kinase activator activity TAS8476561
    GO:0030246carbohydrate binding IEA--
         
    IL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL2:
     Decreased viability of wild-ty 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il2) (see all 16):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  no phenotypic analysis  other  reproductive system  respiratory system 

    IL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il2tm1Hor for IL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL2:
    hsa-mir-484 (MIRT041627), hsa-mir-181c-5p (MIRT025034)

    Block miRNA regulation of human, mouse, rat IL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL2 (see all 10):
    hsa-miR-520d-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-3158-3p hsa-miR-186 hsa-miR-524-5p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL2
    Predesigned siRNA for gene silencing in human, mouse, rat IL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL2

    Clone
    Products:
         
    OriGene clones in human, mouse for IL2 (see all 5)
    OriGene ORF clones in mouse, rat for IL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL2 (NM_000586)
    Sino Biological Human cDNA Clone for IL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL2_HUMAN, P60568: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    plasma membrane3
    cytoskeleton2
    cytosol2
    lysosome2
    mitochondrion2
    vacuole2
    endoplasmic reticulum1
    endosome1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS6608729

    IL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL2 About   (see all 54)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Type I diabetes mellitus0.69
    Intestinal immune network for IgA production0.41
    Graft-versus-host disease0.65
    THC Differentiation Pathway0.38
    3IL2-mediated signaling events
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49
    4Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for IL2
        IL-2 Signaling Pathways
    Th1 Differentiation
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL2 (see all 72)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for IL2
        Lymphocyte Signaling

    3 Tocris Bioscience Pathways for IL2
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for IL2 (see all 6)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response IL-22 signaling pathway
    Immune response CD16 signaling in NK cells
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Immune response Function of MEF2 in T lymphocytes

    Selected BioSystems Pathways for IL2 (see all 18)
        Cytokines and Inflammatory Response
    Spinal Cord Injury
    IL-2 Signaling pathway
    AhR pathway
    Corticotropin-releasing hormone


    2 Reactome Pathways for IL2
        Interleukin receptor SHC signaling
    Interleukin-2 signaling

    1 PharmGKB Pathway for IL2
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for IL2) (see all 13):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    T cell receptor signaling pathway
    Intestinal immune network for IgA production


    IL2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2 (see all 24): 
              HIV Host Response in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL2 (P605683 ENSP000002267304) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFNA1P015623, ENSP000002769274I2D: score=1 STRING: ENSP00000276927
    IL2RBP147843, ENSP000002162234I2D: score=3 STRING: ENSP00000216223
    IFNA13P015623I2D: score=1 
    IL21RQ9HBE53, ENSP000003380104I2D: score=1 STRING: ENSP00000338010
    NGFRP081383, ENSP000001722294I2D: score=1 STRING: ENSP00000172229
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001933negative regulation of protein phosphorylation IEA--
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002903negative regulation of B cell apoptotic process IDA9184696
    GO:0006955immune response TAS2342538
    GO:0007155cell adhesion TAS10929056

    IL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for IL2
      Browse compounds at ApexBio 

    Compounds for IL2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    UniProtKB/Swiss-Prot: IL2_HUMAN, P60568
    Pharmaceutical: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or
    metastatic melanoma

    7 DrugBank Compounds for IL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester-- --target--17139284 17016423 10592235
    2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide-- --target--17139284 17016423 10592235
    5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid-- --target--17139284 17016423 10592235
    SP2456-- --target--17139284 17016423 10592235
    SP4160-- --target--17139284 17016423 10592235
    (1h-Indol-3-Yl)-(2-Mercapto-Ethoxyimino)-Acetic Acid-- --target--10592235
    3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for IL2 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 82.7 318 2017664 (5), 9823934 (5), 7539752 (4), 11306241 (4) (see all 99)
    proleukin 82 67 11943448 (2), 18646697 (2), 7834457 (1), 12974198 (1) (see all 40)
    okt3 80.1 254 8336188 (8), 2160321 (6), 7613643 (6), 8313660 (5) (see all 99)
    dacarbazine 75.1 153 7842406 (3), 9935227 (2), 10873069 (2), 2337862 (2) (see all 92)
    cyclosporin a 74.5 637 1384862 (6), 10589954 (5), 10760803 (5), 12446480 (5) (see all 99)
    il 10 72.6 104 9800291 (3), 11955389 (3), 8901428 (2), 9272647 (2) (see all 82)
    r-il-2 71.8 22 1714392 (2), 1873855 (1), 7695972 (1), 14744937 (1) (see all 16)
    thymidine 69 225 1974593 (2), 1777232 (2), 8288318 (2), 7949016 (2) (see all 99)
    rantes 68.1 140 16644491 (4), 10365778 (3), 9644628 (2), 10369186 (2) (see all 99)
    denileukin diftitox 65.9 43 16224276 (3), 15353540 (1), 16516672 (1), 11594570 (1) (see all 24)



    IL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL2 gene: 
    NM_000586.3  

    Unigene Cluster for IL2:

    Interleukin 2
    Hs.89679  [show with all ESTs]
    Unigene Representative Sequence: S82692
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226730(uc003ier.3) ENST00000477645
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL2 (see all 10):
    hsa-miR-520d-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-3158-3p hsa-miR-186 hsa-miR-524-5p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL2
    Predesigned siRNA for gene silencing in human, mouse, rat IL2
    Clone
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    OriGene clones in human, mouse for IL2 (see all 5)
    OriGene ORF clones in mouse, rat for IL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL2 (NM_000586)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL2
    OriGene qSTAR qPCR primer pairs in human, mouse for IL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL2
      QuantiTect SYBR Green Assays in human, mouse, rat IL2
      QuantiFast Probe-based Assays in human, mouse, rat IL2

    Additional mRNA sequence: 

    AB451325.1 AB451454.1 AF228636.1 AF532913.1 AY283686.1 AY523040.1 BC066254.1 BC066255.1 
    BC066256.1 BC066257.1 BC070338.1 DQ231169.1 DQ861285.1 S77834.1 S77835.1 S82692.1 
    U25676.1 V00564.1 X01586.1 

    1 DOTS entry:

    DT.210021 

    Selected AceView cDNA sequences (see all 40):

    BC066255 CD559748 CD559749 AF532913 CD013917 BC066257 X01586 CD521790 
    CD642113 AF228636 S77834 CD520719 CD559590 V00564 CD640183 BC070338 
    CD640220 CD521982 S82692 BC066254 CD559593 CD559408 CD638487 CD559416 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for IL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGAATATG
    IL2 Expression
    About this image


    IL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Blood (Hematopoietic System)
             Bone marrow-derived hematopoietic stem cells
    IL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89679
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL2 (see all 24): 
              HIV Host Response in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il21 , 5 interleukin 21, 5 69.98(n)1
    58.94(a)1
      3 (18.30 cM)5
    161831  NM_008366.31  NP_032392.11 
     371205235 


    ENSEMBL Gene Tree for IL2 (if available)
    TreeFam Gene Tree for IL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL2 gene
    1 SIMAP similar gene for IL2 using alignment to 5 protein entries:     IL2_HUMAN (see all proteins):
    IL-2

    IL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL2 (see all 151)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs454541911,2
    C--123157486(-) GCAAGA/GAACCC 1 -- ds50010--------
    rs557339111,2
    C--123157558(-) ACTATG/TAGGAA 1 -- ds50012Minor allele frequency- T:0.03NA 122
    rs20697751,2
    C,F,H--123157595(-) TTCCAT/CTGGGT 1 -- ds50016Minor allele frequency- C:0.00NS EA 506
    rs20697741,2
    C,F,H--123157664(-) ACCCTG/ACCCAG 1 -- ds500121Minor allele frequency- A:0.02NS EA NA WA 2246
    rs454744021,2
    --123157678(+) AGATAC/TTGGAG 1 -- ds50010--------
    rs785805281,2
    C--123157683(+) TTGGAA/GAATTC 1 -- ds50010--------
    rs1477912361,2
    --123157834(+) AGTCTA/GCATCT 1 -- ds50010--------
    rs1167141121,2
    C--123157842(+) TCTCTA/GTTCTA 1 -- ds50010--------
    rs2006218411,2
    C--123158229(+) CTGATA/GTGTTT 1 -- ut310--------
    rs20697731,2
    C,F,H--123158382(-) ATTAAC/TATTTT 1 -- int111Minor allele frequency- T:0.02NS EA NA 1396

    HapMap Linkage Disequilibrium report for IL2 (123372625 - 123377880 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL2: --
    Human Gene Mutation Database (HGMD): IL2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IL2
    DNA2.0 Custom Variant and Variant Library Synthesis for IL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147680    OMIM disorders: --

    UniProtKB/Swiss-Prot: IL2_HUMAN, P60568
  • Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia
    (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17

  • Selected diseases for IL2 (see all 387):    
    About MalaCards
    ulcerative colitis    balanoposthitis    erysipeloid    virus associated hemophagocytic syndrome
    kikuchi disease    berylliosis    severe combined immunodeficiency due to il2 deficiency    oral tuberculosis
    chronic berylliosis    giant cell myocarditis    lyell syndrome    trichomoniasis
    conjunctival disease    hemangioendothelioma    farmer's lung    chronic active epstein-barr virus infection
    uremic pruritus    capillary leak syndrome    coccidiosis    eosinophilic meningitis

    Selected diseases from the University of Copenhagen DISEASES database for IL2 (see all 38):
    Renal cell carcinoma     Melanoma     Leukemia     Lymphoma
    Acquired immunodeficiency syndrome     Hypersensitivity reaction type II disease     Carcinoma     Skin disease
    Rheumatoid arthritis     Leukopenia     Severe combined immunodeficiency     Diphtheria
    Tetanus     Sarcoma     Colorectal cancer     Eosinophilia
    Connective tissue disease     Lung disease     Lung cancer     Tuberculosis

    IL2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IL2 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastatic renal cell carcinoma 89.6 629 10685669 (4), 9457403 (4), 7754541 (3), 7490829 (3) (see all 99)
    necrosis 85.5 2740 11490833 (7), 2112520 (5), 12710650 (4), 1700673 (4) (see all 99)
    metastatic melanoma 84.3 507 9215828 (5), 10091789 (4), 12714884 (4), 17576460 (4) (see all 99)
    carcinoma renal cell 82.7 775 20106881 (5), 17264761 (5), 10760767 (4), 10838668 (4) (see all 99)
    tumors 82.2 4831 2302724 (7), 11490833 (7), 18256831 (7), 7523315 (7) (see all 99)
    melanoma 78.7 1101 11125310 (7), 19509154 (6), 7833372 (5), 16365605 (5) (see all 99)
    severe combined immunodeficiency, x-linked 74.1 69 8299698 (3), 7937790 (2), 7930609 (2), 8128231 (1) (see all 35)
    renal cancer 73.6 188 2253233 (4), 9166506 (4), 1567700 (4), 7960603 (3) (see all 99)
    stable disease 73.1 45 16224275 (2), 8249176 (2), 7754541 (1), 11448899 (1) (see all 33)
    autoimmune diseases 71.4 114 1836210 (2), 1976464 (2), 1742421 (2), 12359737 (2) (see all 79)

    Genatlas disease: IL2
    immunodeficiency,severe,combined

    Genetic Association Database (GAD): IL2
    Human Genome Epidemiology (HuGE) Navigator: IL2 (248 documents)
    Tumor Gene Database (TGDB): IL2

    Export disorders for IL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL2 gene, integrated from 10 sources (see all 7052):
    (articles sorted by number of sources associating them with IL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation. (PubMed id 12727483)1, 4, 9 Holweg C.T....Baan C.C. (Transpl. Immunol. 2003)
    2. IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma. (PubMed id 18972297)1, 4, 9 Movahedi M....Amirzargar A.A. (J Asthma 2008)
    3. Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population. (PubMed id 18574615)1, 4, 9 Watanabe Y....Someya T. (Eur Arch Psychiatry Clin Neurosci 2008)
    4. The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women. (PubMed id 20060205)1, 4, 9 Czerny B....Pawlik A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2010)
    5. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. (PubMed id 17152005)1, 4, 9 Dhiman N....Jacobson R.M. (J. Infect. Dis. 2007)
    6. Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population. (PubMed id 17714919)1, 4, 9 Kim Y.K....Kim T.G. (J. Dermatol. Sci. 2007)
    7. IL-2 gene C/T polymorphism is associated with prostate cancer. (PubMed id 17115417)1, 4, 9 Wu H.C....Chen W.C. (J. Clin. Lab. Anal. 2006)
    8. Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection. (PubMed id 15904474)1, 4, 9 Togawa S....Hamajima N. (Helicobacter 2005)
    9. An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosis. (PubMed id 12409183)1, 4, 9 Kikuchi S....Tashiro K. (J. Neurol. Sci. 2002)
    10. Allelic expression and interleukin-2 polymorphisms in multiple sclerosis. (PubMed id 11525806)1, 4, 9 Matesanz F....Alcina A. (J. Neuroimmunol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3558 HGNC: 6001 AceView: IL2 Ensembl:ENSG00000109471 euGenes: HUgn3558
    ECgene: IL2 Kegg: 3558 H-InvDB: IL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL2 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: IL-2http://www.rndsystems.com/molecule_detail.aspx?m=1638
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_2
    SeattleSNPshttp://pga.gs.washington.edu/data/il2/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL2 gene:
    Search GeneIP for patents involving IL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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