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IL1B Gene

protein-coding   GIFtS: 68
GCID: GC02M113587

Interleukin 1, Beta

  See IL1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 1, Beta1 2     catabolin2
IL1F22 3     Interleukin-1 Beta2
IL-1 Beta2 3     Preinterleukin 1 Beta2
IL-12     pro-interleukin-1-beta2
IL1-BETA2     Catabolin3

External Ids:    HGNC: 59921   Entrez Gene: 35532   Ensembl: ENSG000001255387   OMIM: 1477205   UniProtKB: P015843   

Export aliases for IL1B gene to outside databases

Previous GC identifers: GC02M110793 GC02M111508 GC02M113494 GC02M113682 GC02M113303 GC02M106041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL1B Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by
activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1
(CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of
cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of
cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to
inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene
cluster on chromosome 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1B Gene:
IL1B (interleukin 1, beta) is a protein-coding gene. Diseases associated with IL1B include toxic shock syndrome, and central nervous system leukemia. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release,
B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the
inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of
prostaglandin and collagenase from synovial cells

summary for IL1B Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1B gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   STAT3   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL1B promoter sequence
   Search Chromatin IP Primers for IL1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14

IL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M113587:  view genomic region     (about GC identifiers)

Start:
113,587,328 bp from pter      End:
113,594,480 bp from pter
Size:
7,153 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584 (See protein sequence)
Recommended Name: Interleukin-1 beta precursor  
Size: 269 amino acids; 30748 Da
Subunit: Monomer. Interacts with MEFV
Selected PDB 3D structures from and Proteopedia for IL1B (see all 30):
1HIB (3D)        1I1B (3D)        1IOB (3D)        1ITB (3D)        1L2H (3D)        1S0L (3D)    
Secondary accessions: Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6

Explore the universe of human proteins at neXtProt for IL1B: NX_P01584

Explore proteomics data for IL1B at MOPED


See IL1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000567.1  
ENSEMBL proteins: 
 ENSP00000263341   ENSP00000407219   ENSP00000409680   ENSP00000400854  
Reactome Protein details: P01584

IL1B Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant IL1B Protein
R&D Systems Recombinant & Natural Proteins for IL1B (IL-1 beta/IL-1F2)
Enzo Life Sciences proteins for IL1B
OriGene Purified Proteins for IL1B
OriGene Protein Over-expression Lysate for IL1B
OriGene MassSpec for IL1B
OriGene Custom Protein Services for IL1B
GenScript Purified and Recombinant Proteins for IL1B
Novus Biologicals IL1B Proteins
Novus Biologicals IL1B Lysates
Sino Biological Recombinant Protein for IL1B
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for IL1B
Browse Proteins at Cloud-Clone Corp.

 
eBioscience Proteins for IL1B: (see all 4
                    Human IL-1 beta Single-Use ELISA RSG Standard 4 pack

 
antibodies-online proteins for IL1B (177 products) 

 
antibodies-online peptides for IL1B

IL1B Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of IL1B
R&D Systems Antibodies for IL1B (IL-1 beta/IL-1F2)
OriGene Antibodies for IL1B
OriGene Custom Antibody Services for IL1B
Novus Biologicals IL1B Antibodies
Abcam antibodies for IL1B
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibody for IL1B
LSBio Antibodies in human, mouse, rat for IL1B
antibodies-online antibodies for IL1B (429 products) 

IL1B Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL1B
R&D Systems Flow Cytometry Kits for IL1B (IL-1 beta/IL-1F2)         (see all)
GenScript Custom Assay Services for IL1B
Enzo Life Sciences assays for IL1B
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
eBioscience ELISAs for IL1B: (see all 7
                    Human IL-1beta Platinum ELISA 96 tests
antibodies-online kits for IL1B (139 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands
IL: Interleukins and interleukin receptors

Selected InterPro protein domains (see all 7):
 IPR003502 IL-1_propep
 IPR028142 IL-1_fam/FGF_fam
 IPR003296 IL-1_beta
 IPR000975 IL-1
 IPR020877 IL-1_CS

Graphical View of Domain Structure for InterPro Entry P01584

ProtoNet protein and cluster: P01584

5 Blocks protein domains:
IPB000975 Interleukin-1 precursor family signature
IPB002348 IL1/HBGF family signature
IPB003294 Interleukin-1 alpha/beta precursor family signature
IPB003296 Interleukin-1 beta precursor signature
IPB003502 Interleukin-1 propeptide


UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584
Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet
undefined function
Similarity: Belongs to the IL-1 family


Find genes that share domains with IL1B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL1B_HUMAN, P01584
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release,
B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the
inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of
prostaglandin and collagenase from synovial cells

     Genatlas biochemistry entry for IL1B:
interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively
stimulating osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory
response,susceptibility factor for inflammatory bowel diseaes

     Summary: 
IL1B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
            
Blood: Macrophage-like cells, Mature dendritic-like cells       to see all 2 cells

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IMP2989698
GO:0005149interleukin-1 receptor binding NAS1919436
GO:0019904protein domain specific binding IPI16575408
     
Find genes that share ontologies with IL1B           About GenesLikeMe


Phenotypes:
     8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il1b):
 cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
 nervous system  skeleton  tumorigenesis 

Find genes that share phenotypes with IL1B           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for IL1B: Il1btm1Lvp Il1btm1Dch

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL1B
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL1B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1B
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1B

miRNA
Products:
    
miRTarBase miRNAs that target IL1B:
hsa-mir-204-5p (MIRT005830), hsa-mir-21-5p (MIRT005951)

Block miRNA regulation of human, mouse, rat IL1B using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate IL1B:
hsa-miR-205* hsa-miR-3121-3p hsa-miR-1291
SwitchGear 3'UTR luciferase reporter plasmidIL1B 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IL1B
Predesigned siRNA for gene silencing in human, mouse, rat IL1B

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL1B

Clone
Products:
     
OriGene clones in human, mouse for IL1B (see all 7)
OriGene ORF clones in mouse, rat for IL1B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL1B (NM_000576)
Sino Biological Human cDNA Clone for IL1B
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1B

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL1B
Browse ESI BIO Cell Lines and PureStem Progenitors for IL1B 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1B

Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA1-11609 VF6-13869) for IL1B 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IL1B_HUMAN, P01584: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests
that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory
proteins
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol4
nucleus3
plasma membrane3
cytoskeleton2
endoplasmic reticulum2
lysosome2
mitochondrion2
peroxisome2
vacuole2
endosome1
golgi apparatus1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IMP3493774
GO:0005829cytosol TAS--
GO:0030141secretory granule IEA--
GO:0031982vesicle ----

Find genes that share ontologies with IL1B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL1B About   (see all 65)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Interleukin-1 signaling
Interleukin-1 signaling0.45
IL-1 Signaling Pathway0.00
IL1-mediated signaling events0.45
2PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
3NOD-like Receptor Signaling Pathways
Toll-Like receptor Signaling Pathways0.58
IL-1 Family Signaling Pathways0.44
NOD-like Receptor Signaling Pathways0.58
Immune response IL 1 signaling pathway0.42
Inflammasome Activation Pathways0.51
4Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.94
Regulation of toll-like receptor signaling pathway0.93
Toll-like receptor signaling pathway0.94
Chagas disease (American trypanosomiasis)0.32
5MAPK signaling pathway
MAPK signaling pathway0.50
MAPK signaling pathway0.50


Find genes that share SuperPaths with IL1B           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected R&D Systems Pathways for IL1B (see all 7)
    NOD-like Receptor Signaling Pathways
Inflammasome Activation Pathways
IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
IL-1 Family Signaling Pathways
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL1B (see all 38)
    14-3-3 Induced Apoptosis
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Tec Kinases Signaling
Rho Family GTPases

1 Cell Signaling Technology (CST) Pathway for IL1B
    NF-kappaB Signaling

3 Tocris Bioscience Pathways for IL1B
    Akt Pathway
Toll-like Receptor Pathway
MAPK Pathway

Selected GeneGo (Thomson Reuters) Pathways for IL1B (see all 6)
    Immune response Bacterial infections in normal airways
Immune response MIF in innate immunity response
Transcription Role of VDR in regulation of genes involved in osteoporosis
Bacterial infections in CF airways
IL-1 beta-dependent CFTR expression

Selected BioSystems Pathways for IL1B (see all 22)
    Myometrial Relaxation and Contraction Pathways
MAPK signaling pathway
NOD pathway
Cytokines and Inflammatory Response
Senescence and Autophagy


2 Reactome Pathways for IL1B
    Interleukin-1 signaling
Interleukin-1 processing


Selected Kegg Pathways  (Kegg details for IL1B) (see all 30):
    MAPK signaling pathway
Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Apoptosis
Osteoclast differentiation

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1B (see all 37): 
          Antiviral Response in human mouse rat
          Multiple Sclerosis in human mouse rat
          Wound Healing in human mouse rat
          GABA & Glutamate in human mouse rat
          Inflammasomes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for IL1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for IL1B (P015842, 3 ENSP000002633414) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
InteractantInteraction Details
GeneCardExternal ID(s)
IL1R1P147782, 3, ENSP000002339464MINT-24831 I2D: score=8 STRING: ENSP00000233946
IL1RAPQ9NPH33, ENSP000000725164I2D: score=3 STRING: ENSP00000072516
ADRB2P075503, ENSP000003053724I2D: score=2 STRING: ENSP00000305372
CASP4P496623, ENSP000003885664I2D: score=2 STRING: ENSP00000388566
MAPK8IP2Q133873, ENSP000003305724I2D: score=1 STRING: ENSP00000330572
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Gene Ontology (GO): Selected biological process terms (see all 74):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000165MAPK cascade IMP--
GO:0000187activation of MAPK activity IDA10748004
GO:0001660fever generation IEA--
GO:0001934positive regulation of protein phosphorylation NAS16477012
GO:0002711positive regulation of T cell mediated immunity IC1919436

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for IL1B available from Tocris Bioscience    About this table
CompoundAction CAS #
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

4 DrugBank Compounds for IL1B    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Minocycline-- 10118-90-8targetmodulator11246672 8943052 9413935 12211491
RilonaceptArcalyst (see all 2)501081-76-1targetbinder23553601 23319019
CanakinumabACZ-885 (see all 2)914613-48-2targetbinder19169963
Gallium nitrate-- 13494-90-1targetantagonist16122880

Selected Novoseek inferred chemical compound relationships for IL1B gene (see all 136)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pge2 85.5 1669 15135319 (8), 19452719 (8), 17438251 (7), 1668251 (6) (see all 99)
rantes 80.6 362 11600537 (6), 19080516 (6), 15499983 (6), 11063385 (5) (see all 99)
endotoxin 78.9 487 15499983 (6), 9659298 (5), 10908988 (5), 15325407 (5) (see all 99)
il 10 71.4 89 17022949 (3), 18832862 (3), 10645445 (2), 16842617 (2) (see all 63)
dexamethasone 71.1 456 17513787 (6), 9758209 (5), 10657942 (5), 19435930 (4) (see all 99)
nitric oxide 70.8 1245 10025918 (6), 1384465 (6), 11247871 (6), 9160463 (5) (see all 99)
cycloheximide 69.4 155 1384465 (3), 1732280 (2), 9144567 (2), 1918980 (2) (see all 99)
prostaglandin 69.1 243 1641502 (4), 8140125 (3), 9419743 (3), 9047011 (3) (see all 99)
indomethacin 63.5 183 12639911 (4), 9627083 (4), 10772282 (4), 1348040 (4) (see all 99)
sb 203580 63.3 64 12921636 (4), 18348730 (4), 17207362 (2), 20416175 (2) (see all 47)

Selected PharmGKB related drug/compound annotations for IL1B gene (see all 10)    About this table
Drug/compound PharmGKB Annotation
BisphosphonatesCA  
aspirinCA  
clodronateCA  
etidronic acidCA  
lansoprazoleCA  
omeprazoleCA  
pravastatinCA  
rabeprazoleCA  
risedronateCA  
tiludronateCA  



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IL1B gene: 
NM_000576.2  

Unigene Cluster for IL1B:

Interleukin 1, beta
Hs.126256  [show with all ESTs]
Unigene Representative Sequence: AK313983
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000263341(uc002tih.1 uc002tii.1) ENST00000491056 ENST00000487639
ENST00000418817 ENST00000432018 ENST00000416750 ENST00000496280 ENST00000477398

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IL1B using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate IL1B:
hsa-miR-205* hsa-miR-3121-3p hsa-miR-1291
SwitchGear 3'UTR luciferase reporter plasmidIL1B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IL1B
Predesigned siRNA for gene silencing in human, mouse, rat IL1B
Clone
Products:
     
OriGene clones in human, mouse for IL1B (see all 7)
OriGene ORF clones in mouse, rat for IL1B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL1B (NM_000576)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1B
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL1B
OriGene qSTAR qPCR primer pairs in human, mouse for IL1B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL1B
  QuantiTect SYBR Green Assays in human, mouse, rat IL1B
  QuantiFast Probe-based Assays in human, mouse, rat IL1B
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA1-11609 VF6-13869) for IL1B 

Additional mRNA sequence: 

AB451494.1 AF043335.1 AK313983.1 BC008678.1 BT007213.1 CR407679.1 K02770.1 M15330.1 
M54933.1 X02532.1 X56087.1 

8 DOTS entries:

DT.454455  DT.95307325  DT.101987199  DT.100026384  DT.121014363  DT.121014359  DT.95375716  DT.102824241 

Selected AceView cDNA sequences (see all 440):

BP336620 AA381466 BP337935 BM556327 CA431510 CA488355 CA307004 BP337595 
BP336921 AA381270 CA442834 CB154775 BP335812 BQ001221 CD370442 BX108825 
AA381512 BP337375 AA381581 CD240414 BP336474 BP335557 AA381823 BP336089 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL1B (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:              -     -     -                 -           -                                       
SP2:                    -     -                 -           -                                       
SP3:                          -                 -           -                                       
SP4:              -     -     -                 -                                                   
SP5:                                            -           -                                       


ECgene alternative splicing isoforms for IL1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAATTTGTGT
IL1B Expression
About this image


IL1B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 11) fully expand
 
 Zygote (Early Embryonic Tissues)    fully expand to see all 3 entries
         Zygote Zygote
 
 Inner Cell Mass (Early Embryo)    fully expand to see all 3 entries
         Zygote Zygote
 
 Trophoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
         Zygote Zygote
 
 Blood (Cardiovascular System)    fully expand to see all 2 entries
         Granulocytes Peripheral Blood
 
 Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
         Villous Cytotrophoblast Cells Chorionic Villus
IL1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IL1B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.126256
    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1B (see all 37): 
          Antiviral Response in human mouse rat
          Multiple Sclerosis in human mouse rat
          Wound Healing in human mouse rat
          GABA & Glutamate in human mouse rat
          Inflammasomes in human mouse rat

Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for IL1B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL1B
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QuantiFast Probe-based Assays in human, mouse, rat IL1B
In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL1B gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il1b1 , 5 interleukin 1 beta1, 5 78.45(n)1
69.55(a)1
  2 (62.97 cM)5
161761  NM_008361.31  NP_032387.11 
 1293645705 
chicken
(Gallus gallus)
Aves IL-1BETA6
Gallus gallus interleukin 1, beta (IL1B), mRNA.
25(a)
1 ↔ 1
JH375214.1(1205-3576)
tropical clawed frog
(Xenopus tropicalis)
Amphibia il1b1 interleukin 1, beta 48.77(n)
39.3(a)
  100487038  XM_002932572.2  XP_002932618.1 
zebrafish
(Danio rerio)
Actinopterygii il1b6
interleukin 1, beta
21(a)
1 ↔ 1
10(46393914-46401024) ENSDARG00000005419


ENSEMBL Gene Tree for IL1B (if available)
TreeFam Gene Tree for IL1B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IL1B gene
1 SIMAP similar gene for IL1B using alignment to 5 protein entries:     IL1B_HUMAN (see all proteins):
IL1b

Find genes that share paralogs with IL1B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL1B (see all 257)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs30872611,2
F--106041748(-) GCACAC/TTTGGA 1 -- ds50011Minor allele frequency- T:0.17NA 40
rs58334641,2
C--106050892(+) CTTTC-/TTTT  
        
tcttt
1 -- us2k10--------
rs558158771,2
C--106050965(+) TTTCT-/TC/TCTT/TCT
TTCTTTCTTTCTT
CTTTC
1 -- us2k12NA 4
rs1844583871,2
--113100427(+) CTCCTA/GTCTGA 1 -- ds50010--------
rs1163198351,2
F--113100485(+) CATAGC/TGCTTG 1 -- ds50011Minor allele frequency- T:0.01WA 118
rs28535501,2
C,F,O,H--113100584(-) CACATC/TTGGAA 1 -- ds500129Minor allele frequency- T:0.18NS EA NA WA CSA 2712
rs1476364071,2
--113100617(+) CAACAA/GAAATA 1 -- ds50010--------
rs39173621,2
C,F,H--113100681(-) AGTGCT/CGCAAA 1 -- ds500122Minor allele frequency- C:0.02NS EA NA MN WA 2362
rs27089741,2
C--113100784(+) CAGGAA/GAGACC 1 -- ds50015Minor allele frequency- G:0.00MN 404
rs2002953131,2
--113100790(+) GACCC-/TTTTTT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for IL1B (113587328 - 113594480 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IL1B: --
Human Gene Mutation Database (HGMD): IL1B
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IL1B
DNA2.0 Custom Variant and Variant Library Synthesis for IL1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147720   
OMIM disorders: 137215  
Selected diseases for IL1B (see all 64):    
About MalaCards
toxic shock syndrome    central nervous system leukemia    poems syndrome    bagassosis
staphylococcal toxic shock syndrome    prosthetic joint infection    gastric cancer risk after h. pylori infection    glossitis
h. pylori infection    cervical adenitis    recurrent corneal erosion    laryngitis
endotoxin hyporesponsiveness    intervertebral disc disease    gastroesophageal junction adenocarcinoma    vaginitis
bacterial vaginosis    stenotrophomonas maltophilia    aseptic meningitis    cryopyrin-associated periodic syndrome

Selected diseases from the University of Copenhagen DISEASES database for IL1B (see all 36):
Arthritis     Periodontitis     Vascular disease     Inflammatory bowel disease
Cancer     Brain disease     Diabetes mellitus     Asthma
Hypersensitivity reaction type II disease     Respiratory failure     Pneumonia     Kidney disease
Skin disease     Alzheimer's disease     Peritonitis     Gastritis
Synovitis     Heart disease     Pancreatitis     Meningitis

Find genes that share disorders with IL1B           About GenesLikeMe

Selected Novoseek inferred disease relationships for IL1B gene (see all 94)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis 94.6 6807 8908543 (6), 2239094 (5), 9223915 (5), 10958731 (5) (see all 99)
inflammation 87.4 725 11776404 (4), 8777275 (4), 8990190 (4), 10444264 (3) (see all 99)
tumors 85.7 5675 8908543 (6), 1966551 (6), 1752785 (5), 9223915 (5) (see all 99)
rheumatoid arthritis 79 217 7608561 (3), 2057724 (2), 8135776 (2), 15304675 (2) (see all 99)
osteoarthritis 72 126 19835118 (3), 2057724 (2), 1616355 (2), 7586981 (2) (see all 95)
response acute phase 67.1 37 8354339 (2), 11250916 (1), 12177794 (1), 18262272 (1) (see all 30)
arthritis 67 126 1616355 (2), 11120857 (2), 17397533 (2), 8275587 (2) (see all 88)
periodontal diseases 66.4 98 16570465 (3), 9203094 (2), 17378884 (2), 15002890 (2) (see all 63)
sepsis 63.9 142 9773833 (4), 17877801 (3), 18274637 (2), 8945019 (2) (see all 99)
systemic inflammatory response syndrome 59.9 34 8379598 (2), 7680670 (2), 10101684 (1), 16736416 (1) (see all 21)

Genetic Association Database (GAD): IL1B
Human Genome Epidemiology (HuGE) Navigator: IL1B (1184 documents)

Export disorders for IL1B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IL1B gene, integrated from 10 sources (see all 7150):
(articles sorted by number of sources associating them with IL1B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human interleukin-1 beta gene. (PubMed id 2954882)1, 2, 3 Bensi G.... Melli M. (Gene 1987)
  2. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. (PubMed id 2989698)1, 2, 3 March C.J.... Cosman D. (Nature 1985)
  3. Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women. (PubMed id 19904560)1, 4, 9 Qian N....Hu Z. (J. Cancer Res. Clin. Oncol. 2010)
  4. Relationship between IL-1beta gene polymorphism and gastric mucosal IL-1beta levels in patients with Helicobacter pylori infection. (PubMed id 16143884)1, 4, 9 Xuan J....Takagi A. (J. Gastroenterol. 2005)
  5. Interleukin 1-beta responses to bacterial toxins and sudden infant death syndrome. (PubMed id 15325407)1, 4, 9 Moscovis S.M....Blackwell C.C. (FEMS Immunol. Med. Microbiol. 2004)
  6. [The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis]. (PubMed id 19220961)1, 4, 9 Chen X.Q....Chen Y.C. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009)
  7. A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. The interleukin-1beta:interleukin-1 receptor antagonist balance in atherosclerosis. (PubMed id 19574724)1, 4, 9 Olofsson P.S....SirsjAP A. (Circ. J. 2009)
  8. Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis. (PubMed id 12775358)1, 4, 9 Schrijver H.M....Uitdehaag B.M. (Mediators Inflamm. 2003)
  9. Interleukin (IL) 1beta and IL-10 gene polymorphism in chronic hepatitis C patients with normal or elevated alanine aminotransferase levels. (PubMed id 12705485)1, 4, 9 Abbas Z. and Moatter T. (J Pak Med Assoc 2003)
  10. The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer. (PubMed id 11531943)1, 4, 9 Garcia-Gonzalez M.A....PeA+a A.S. (Clin. Exp. Immunol. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3553 HGNC: 5992 AceView: IL1B Ensembl:ENSG00000125538 euGenes: HUgn3553
ECgene: IL1B Kegg: 3553 H-InvDB: IL1B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL1B Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL1B Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
SeattleSNPshttp://pga.gs.washington.edu/data/il1b/
SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL1B gene:
Search GeneIP for patents involving IL1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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