Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL1B Gene

Aliases for IL1B Gene

  • Interleukin 1, Beta 2 3
  • IL-1 Beta 3 4
  • Catabolin 3 4
  • IL1F2 3 4
  • Pro-Interleukin-1-Beta 3
  • Preinterleukin 1 Beta 3
  • Interleukin-1 Beta 3
  • IL1-BETA 3
  • IL-1 3

External Ids for IL1B Gene

Summaries for IL1B Gene

Entrez Gene Summary for IL1B Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1B Gene

IL1B (Interleukin 1, Beta) is a Protein Coding gene. Diseases associated with IL1B include central nervous system leukemia and toxic shock syndrome. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding.

UniProtKB/Swiss-Prot for IL1B Gene

  • Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Tocris Summary for IL1B Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1B Gene

Genomics for IL1B Gene

Genomic Location for IL1B Gene

Start:
112,829,751 bp from pter
End:
112,836,903 bp from pter
Size:
7,153 bases
Orientation:
Minus strand

Genomic View for IL1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1B Gene

Regulatory Elements for IL1B Gene

Proteins for IL1B Gene

  • Protein details for IL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01584-IL1B_HUMAN
    Recommended name:
    Interleukin-1 beta
    Protein Accession:
    P01584
    Secondary Accessions:
    • Q53X59
    • Q53XX2
    • Q7M4S7
    • Q7RU01
    • Q96HE5
    • Q9UCT6

    Protein attributes for IL1B Gene

    Size:
    269 amino acids
    Molecular mass:
    30748 Da
    Quaternary structure:
    • Monomer. Interacts with MEFV.

    Three dimensional structures from OCA and Proteopedia for IL1B Gene

neXtProt entry for IL1B Gene

Proteomics data for IL1B Gene at MOPED

Post-translational modifications for IL1B Gene

No Post-translational modifications

Other Protein References for IL1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IL1B Gene

Domains for IL1B Gene

Gene Families for IL1B Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • IL :Interleukins and interleukin receptors

UniProtKB/Swiss-Prot:

IL1B_HUMAN
Domain:
  • The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function:
    • P01584
Family:
  • Belongs to the IL-1 family.:
    • P01584
genes like me logo Genes that share domains with IL1B: view

Function for IL1B Gene

Molecular function for IL1B Gene

GENATLAS Biochemistry: interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively stimulating osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory response,susceptibility factor for inflammatory bowel diseaes
UniProtKB/Swiss-Prot Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

LifeMap Function Summary for IL1B Gene

IL1B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IMP 2989698
GO:0005149 interleukin-1 receptor binding NAS 1919436
GO:0019904 protein domain specific binding IPI 16575408
genes like me logo Genes that share ontologies with IL1B: view
genes like me logo Genes that share phenotypes with IL1B: view

Animal Models for IL1B Gene

MGI Knock Outs for IL1B:

miRNA for IL1B Gene

miRTarBase miRNAs that target IL1B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL1B Gene

Localization for IL1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1B Gene

Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1B Gene COMPARTMENTS Subcellular localization image for IL1B gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
peroxisome 2
vacuole 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IMP 3493774
GO:0005829 cytosol TAS --
GO:0030141 secretory granule IEA --
GO:0031982 vesicle --
genes like me logo Genes that share ontologies with IL1B: view

Pathways for IL1B Gene

genes like me logo Genes that share pathways with IL1B: view

Gene Ontology (GO) - Biological Process for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0000187 activation of MAPK activity IDA 10748004
GO:0001660 fever generation IEA --
GO:0001934 positive regulation of protein phosphorylation NAS 16477012
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IL1B: view

Compounds for IL1B Gene

(5) Tocris Compounds for IL1B Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines [6501-72-0]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(4) Drugbank Compounds for IL1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Canakinumab
  • ACZ-885
914613-48-2 target binder
Gallium nitrate
13494-90-1 target antagonist
Minocycline
10118-90-8 target modulator
Rilonacept
  • Arcalyst
501081-76-1 target binder

(136) Novoseek inferred chemical compound relationships for IL1B Gene

Compound -log(P) Hits PubMed IDs
pge2 85.5 376
rantes 80.6 186
endotoxin 78.9 210
il 10 71.4 78
dexamethasone 71.1 202

(10) PharmGKB related drug/compound annotations for IL1B Gene

genes like me logo Genes that share compounds with IL1B: view

Transcripts for IL1B Gene

Unigene Clusters for IL1B Gene

Interleukin 1, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -

Relevant External Links for IL1B Gene

GeneLoc Exon Structure for
IL1B
ECgene alternative splicing isoforms for
IL1B

Expression for IL1B Gene

mRNA expression in normal human tissues for IL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1B Gene

This gene is overexpressed in Whole Blood (17.8) and Stomach (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL1B Gene

SOURCE GeneReport for Unigene cluster for IL1B Gene Hs.126256

genes like me logo Genes that share expressions with IL1B: view

Orthologs for IL1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1B 36
  • 99.5 (n)
  • 99.26 (a)
IL1B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL1B 36
  • 75.38 (n)
  • 62.12 (a)
IL1B 37
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1B 36
  • 78.28 (n)
  • 65.15 (a)
IL1B 37
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1b 36
  • 78.45 (n)
  • 69.55 (a)
Il1b 16
Il1b 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1B 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1B 37
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1b 36
  • 76.32 (n)
  • 68.42 (a)
chicken
(Gallus gallus)
Aves IL-1BETA 37
  • 25 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il1b 36
  • 48.77 (n)
  • 39.3 (a)
zebrafish
(Danio rerio)
Actinopterygii il1b 37
  • 21 (a)
OneToOne
Species with no ortholog for IL1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1B Gene

ENSEMBL:
Gene Tree for IL1B (if available)
TreeFam:
Gene Tree for IL1B (if available)

Paralogs for IL1B Gene

Selected SIMAP similar genes for IL1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IL1B: view

No data available for Paralogs for IL1B Gene

Variants for IL1B Gene

Sequence variations from dbSNP and Humsavar for IL1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15610 -- 112,829,945(-) TAGCA(G/T)TGTCT utr-variant-3-prime
rs16062 -- 112,833,504(-) CACTA(C/T)AGCAA reference, synonymous-codon, utr-variant-5-prime
rs16944 -- 112,837,290(+) GCCTC(A/G)GGAGC upstream-variant-2KB
rs1071676 -- 112,829,856(-) ATTAA(C/G)ACTGA utr-variant-3-prime
rs1133555 -- 112,836,760(-) AGGCA(A/C)AAGGC utr-variant-5-prime, upstream-variant-2KB

Relevant External Links for IL1B Gene

HapMap Linkage Disequilibrium report
IL1B
Human Gene Mutation Database (HGMD)
IL1B

No data available for Structural Variations from Database of Genomic Variants (DGV) for IL1B Gene

Disorders for IL1B Gene

(1) OMIM Diseases for IL1B Gene (147720)

(94) Novoseek inferred disease relationships for IL1B Gene

Disease -log(P) Hits PubMed IDs
necrosis 94.6 258
inflammation 87.4 149
tumors 85.7 278
rheumatoid arthritis 79 124
osteoarthritis 72 107

Relevant External Links for IL1B

Genetic Association Database (GAD)
IL1B
Human Genome Epidemiology (HuGE) Navigator
IL1B
genes like me logo Genes that share disorders with IL1B: view

No data available for UniProtKB/Swiss-Prot for IL1B Gene

Publications for IL1B Gene

  1. Lack of association with interleukin 1 receptor antagonist and interleukin-1beta gene polymorphisms in sarcoidosis patients. (PMID: 11127488) Niimi T. … Ueda R. (Respir Med 2000) 3 23 49
  2. Polymorphisms of the IL-1 gene complex in coal miners with silicosis. (PMID: 11241561) Yucesoy B. … Luster M.I. (Am. J. Ind. Med. 2001) 3 23 49
  3. Genetic association studies of interleukin-1 (IL-1A and IL-1B) and interleukin-1 receptor antagonist genes and the risk of Alzheimer's disease. (PMID: 11079552) Minster R.L. … Kamboh M.I. (Ann. Neurol. 2000) 3 23 49
  4. Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients. (PMID: 11498264) Niino M. … Tashiro K. (J. Neuroimmunol. 2001) 3 23 49
  5. Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and Crohn disease in multiple populations from northeast England. (PMID: 11686217) Craggs A. … Mansfield J. (Scand. J. Gastroenterol. 2001) 3 23 49

Products for IL1B Gene

Sources for IL1B Gene

Back to Top

Content