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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1RN Gene

protein-coding   GIFtS: 64
GCID: GC02P113864

Interleukin 1 Receptor Antagonist

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 1 Receptor Antagonist1 2     DIRA2 5
Interleukin-1 Receptor Antagonist Protein1 2     MVCD42 5
ICIL-1RA2 3     Intracellular Interleukin-1 Receptor Antagonist1
IL-1RN2 3     IL-1ra32
IL-1ra2 3     IL1RN (IL1F3)2
IL1F32 3     Intracellular IL-1 Receptor Antagonist Type II2
IL1RA2 3     Intracellular Interleukin-1 Receptor Antagonist (IcIL-1ra)2
IRAP2 3     Type II Interleukin-1 Receptor Antagonist2
IL1 Inhibitor2 3     Anakinra3

External Ids:    HGNC: 60001   Entrez Gene: 35572   Ensembl: ENSG000001366897   OMIM: 1476795   UniProtKB: P185103   

Export aliases for IL1RN gene to outside databases

Previous GC identifers: GC02P111081 GC02P111796 GC02P113782 GC02P113970 GC02P113591 GC02P106329


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1RN Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the
activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin
1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene
cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated
with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants
encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1RN Gene: 
IL1RN (interleukin 1 receptor antagonist) is a protein-coding gene. Diseases associated with IL1RN include polymyalgia rheumatica, and osteoporotic fracture, and among its related super-pathways are IL1-mediated signaling events and Interferon Signaling. GO annotations related to this gene include interleukin-1 receptor binding and interleukin-1, Type I receptor binding. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510
Function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with
the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor
IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter
association is unsure

Gene Wiki entry for IL1RN (Interleukin 1 receptor antagonist) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1RN gene promoter:
         FOXI1   HFH-3   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): IL1RN promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1RN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1RN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.2   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14.2

IL1RN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1RN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113864:  view genomic region     (about GC identifiers)

Start:
113,864,791 bp from pter      End:
113,891,593 bp from pter
Size:
26,803 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510 (See protein sequence)
Recommended Name: Interleukin-1 receptor antagonist protein precursor  
Size: 177 amino acids; 20055 Da
Subcellular location: Isoform 1: Secreted
Subcellular location: Isoform 2: Cytoplasm
Subcellular location: Isoform 3: Cytoplasm
Subcellular location: Isoform 4: Cytoplasm
6 PDB 3D structures from and Proteopedia for IL1RN:
1ILR (3D)        1ILT (3D)        1IRA (3D)        1IRP (3D)        1ITN (3D)        2IRT (3D)    
Secondary accessions: A8K4G1 Q14628 Q53SC2 Q7RTZ4 Q96GD6 Q9UPC0
Alternative splicing: 4 isoforms:  P18510-1   P18510-2   P18510-3   P18510-4   

Explore the universe of human proteins at neXtProt for IL1RN: NX_P18510

Explore proteomics data for IL1RN at MOPED 

IL1RN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL1RN Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_000568.1  NP_776213.1  NP_776214.1  NP_776215.1  

ENSEMBL proteins: 
 ENSP00000387210   ENSP00000354816   ENSP00000259206   ENSP00000329072   ENSP00000387173  
Reactome Protein details: P18510
Human Recombinant Protein Products for IL1RN: 
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R&D Systems Recombinant & Natural Proteins for IL1RN (IL-1ra/IL-1F3)
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OriGene Purified Proteins for IL1RN
OriGene Protein Over-expression Lysate for IL1RN
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Novus Biologicals IL1RN Proteins
Novus Biologicals IL1RN Lysates
Sino Biological Recombinant Protein for IL1RN
Sino Biological Cell Lysate for IL1RN 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IDA10443688
GO:0005622intracellular NAS7629520
GO:0005634nucleus IDA--
GO:0005737cytoplasm IDA--

IL1RN for ontologies           About GeneDecksing



IL1RN Antibody Products: 
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Abcam antibodies for IL1RN
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LSBio Antibodies in human, mouse, rat for IL1RN 

Assay Products for IL1RN: 
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GenScript Custom Assay Services for IL1RN
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

5 InterPro protein domains:
 IPR003297 IL-1RA/IL-36
 IPR000975 Interleukin_1
 IPR020877 Interleukin-1_CS
 IPR027166 IL-1RA
 IPR008996 Cytokine_IL1-like

Graphical View of Domain Structure for InterPro Entry P18510

ProtoNet protein and cluster: P18510

2 Blocks protein domains:
IPB000975 Interleukin-1 precursor family signature
IPB003297 Interleukin-1 receptor antagonist precursor IL-1RA signature



IL1RN for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL1RA_HUMAN, P18510
Function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with
the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor
IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter
association is unsure

     Genatlas biochemistry entry for IL1RN:
interleukin 1,receptor antagonist,with a secreted and an alternatively spliced intracellular form

     Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005149interleukin-1 receptor binding IDA2137200
GO:0005150interleukin-1, Type I receptor binding IPI1828071
GO:0005151interleukin-1, Type II receptor binding IPI1830582
GO:0005152interleukin-1 receptor antagonist activity TAS7629520
GO:0045352interleukin-1 Type I receptor antagonist activity IDA1828071
     
IL1RN for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IL1RN:
 Synthetic lethal with c-Myc af 

     10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il1rn):
 cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
 immune system  integument  mortality/aging  reproductive system  skeleton 

IL1RN for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL1RN: Il1rntm1Nick Il1rntm1Dih Il1rntm1Sush Il1rntm1Yiw

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL1RN 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL1RN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1RN 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1RN 

miRNA
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hsa-miR-224 hsa-miR-122 hsa-miR-516b hsa-miR-513a-5p
SwitchGear 3'UTR luciferase reporter plasmidIL1RN 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): IL1RN (NM_000577)
Sino Biological Human cDNA Clone for IL1RN
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1RN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1RN
Sirion Biotech Customized lentivirus for stable overexpression of IL1RN 
                     Customized lentivirus expression plasmids for stable overexpression of IL1RN 

Cell Line
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Search LifeMap BioReagents cell lines for IL1RN
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RN


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL1RN About   (see all 8)                                                                                              See pathways by source

SuperPathContained pathways About
1Interleukin-1 signaling
IL1-mediated signaling events0.39
Interleukin-1 signaling0.39
2Interferon Signaling
Cytokine Signaling in Immune system0.61
3Immune System
Immune System0.56
4Interleukin-3, 5 and GM-CSF signaling
Signaling by Interleukins0.45
5Development Prolactin receptor signaling
Leptin signaling pathway0.35

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Cell Signaling Technology (CST) Pathway for IL1RN
    Jak/Stat Pathway

4 BioSystems Pathways for IL1RN
    IL-1 Signaling Pathway
SIDS Susceptibility Pathways
Leptin signaling pathway
IL1-mediated signaling events


4        Reactome Pathways for IL1RN
    Interleukin-1 signaling
Cytokine Signaling in Immune system
Signaling by Interleukins
Immune System



IL1RN for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1RN

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for IL1RN (P185102, 3 ENSP000002592064) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL1R1P147782, 3, ENSP000002339464MINT-25085 I2D: score=7 STRING: ENSP00000233946
IL1R2P279303, ENSP000003309594I2D: score=4 STRING: ENSP00000330959
IL1RL2ENSP000002642574STRING: ENSP00000264257
POT1ENSP000003502494STRING: ENSP00000350249
TERF2IPENSP000003000864STRING: ENSP00000300086
About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001960negative regulation of cytokine-mediated signaling pathway IDA2137200
GO:0002439chronic inflammatory response to antigenic stimulus IEA--
GO:0006629lipid metabolic process IEA--
GO:0006953acute-phase response IDA9185517
GO:0006955immune response NAS7629520

IL1RN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL1RN for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL1RN (IL1RA)

UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510
Pharmaceutical: Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing
the progression of structural damage in moderately to severely active rheumatoid arthritis

10/120 Novoseek inferred chemical compound relationships for IL1RN gene (see all 120)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
anakinra 82.8 44 12932294 (3), 16980212 (2), 16751154 (2), 12236617 (1) (see all 33)
endotoxin 66.3 71 11900341 (3), 8219190 (3), 8299563 (2), 7714108 (2) (see all 49)
il 10 62.6 26 18339663 (5), 18832862 (3), 16842617 (2), 16905295 (2) (see all 16)
cellulose triacetate 46.5 6 7890436 (4), 9355078 (1)
neopterin 46.2 18 16273760 (2), 9060965 (2), 8528884 (2), 7814891 (2) (see all 11)
rantes 45.8 21 15645140 (2), 9215253 (2), 16078996 (2), 18225444 (1) (see all 16)
pge2 44.1 41 9416852 (2), 9834469 (2), 7615809 (2), 7593552 (2) (see all 29)
polysulfone 41.7 6 11775226 (3), 15814541 (1), 12784048 (1)
gold sodium thiomalate 39.5 2 7881833 (1)
cuprophan 35.3 8 7890436 (3), 7619385 (1), 10857769 (1), 10879665 (1)

Search CenterWatch for drugs/clinical trials and news about IL1RN / IL1RA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL1RN gene (4 alternative transcripts): 
NM_000577.4  NM_173841.2  NM_173842.2  NM_173843.2  

Unigene Cluster for IL1RN:

Interleukin 1 receptor antagonist
Hs.81134  [show with all ESTs]
Unigene Representative Sequence: BC068441
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000465812 ENST00000463073 ENST00000409052(uc002tix.1) ENST00000361779(uc002tiy.3 uc002tja.3)
ENST00000259206(uc002tiz.3) ENST00000354115(uc002tjb.3) ENST00000486167
ENST00000409930 ENST00000472292
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1RN
4 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1RN:
hsa-miR-224 hsa-miR-122 hsa-miR-516b hsa-miR-513a-5p
SwitchGear 3'UTR luciferase reporter plasmidIL1RN 3' UTR sequence
Inhib. RNA
Products:
     
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Clone
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OriGene ORF clones in mouse, rat for IL1RN
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GenScript: all cDNA clones in your preferred vector (see all 4): IL1RN (NM_000577)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1RN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1RN
Sirion Biotech Customized lentivirus for stable overexpression of IL1RN 
                     Customized lentivirus expression plasmids for stable overexpression of IL1RN 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1RN
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1RN

Additional mRNA sequence: 

AF043143.1 AJ005835.1 AK290898.1 AK290926.1 BC009745.2 BC068441.1 M55646.1 X52015.1 
X53296.1 X84348.1 

10 DOTS entries:

DT.445015  DT.95299944  DT.100036266  DT.100822280  DT.100734138  DT.75180886  DT.92427796  DT.95082557 
DT.95299950  DT.95313026 

24/157 AceView cDNA sequences (see all 157):

AJ005835 CB305886 AI983971 BU626944 CR625646 CA307165 AW272661 X84348 
AF043143 BU608443 CR606622 BM978858 CD370507 CD368886 BI335900 CR605915 
BC068441 M55646 AA497140 CA309172 CR616671 CR619093 BX406656 BX280976 

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IL1RN (see all 10)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1:                                -     -     -                 -     -     -                                             
SP2:                    -           -     -     -                 -     -     -                                             
SP3:                                -     -     -                 -     -     -                                             
SP4:                          -     -     -     -                 -     -     -                                             
SP5:                    -     -     -     -     -                 -     -     -                                             


ECgene alternative splicing isoforms for IL1RN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL1RN expression in normal human tissues (normalized intensities)      IL1RN embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCTGGATCC
IL1RN Expression
About this image


IL1RN expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/9 selected tissues (see all 9) fully expand
 
 Lung (Respiratory System)    fully expand to see all 2 entries
         Basal Cells Respiratory Bronchioles
         bronchoalveolar lavage cells   
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Peripheral Blood Immature Myeloid Dendritic Cells   
         bone marrow-derived macrophages   
 
 Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
         Tongue   
 
 Esophagus (Gastrointestinal Tract)
         esophageal epithelium   
 
 Uterus (Reproductive System)
         cervix   

See IL1RN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL1RN

SOURCE GeneReport for Unigene cluster: Hs.81134

UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510
Tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells

    SABiosciences Expression via Pathway-Focused PCR Arrays including IL1RN (see all 8): 
          NFKB Signaling Targets in human mouse rat
          Inflammatory Response & Autoimmunity in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Common Cytokines in human mouse rat

Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1RN
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1RN
In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL1RN gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il1rn1 , 5 interleukin 1 receptor antagonist1, 5 81.17(n)1
76.27(a)1
  2 (16.36 cM)5
161811  NM_001039701.31  NP_001034790.11 
 243368535 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 4)
Uncharacterized protein
(see all 4)
35(a)
34(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
GL343238.1(908975-910584)
GL343238.1(853473-859585)


ENSEMBL Gene Tree for IL1RN (if available)
TreeFam Gene Tree for IL1RN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IL1RN gene
IL36A2  IL36B2  IL372  IL36RN2  IL1F102  IL36G2  
2 SIMAP similar genes for IL1RN using alignment to 1 protein entry:     IL1RA_HUMAN:
IL1F10    IL36RN

IL1RN for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/590 SNPs in IL1RN are shown (see all 590)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219131611,2
C,Fpathogenic1113402295(+) CCATTG/TAGCCT 8 E * stg11Minor allele frequency- T:0.00NA 4552
rs783662921,2
C--106330548(+) GCACA-/GGTCAG 3 -- int10--------
rs16651921,2
A--106333148(+) TCTTCC/TTCTTC 3 -- int1 trp30--------
rs630341631,2
C--106333148(+) TCTTC-/TTCTTC 3 -- int10--------
rs1425334741,2
--113387202(+) AATCCA/TATCTA 3 -- us2k10--------
rs42519541,2
C,F--113387251(+) AACCAC/TATGCC 3 -- us2k14Minor allele frequency- T:0.04NS NA WA 212
rs1860291951,2
C--113387252(+) ACCACA/GTGCCA 3 -- us2k10--------
rs1909029151,2
--113387283(+) CCAGTC/TTTCAC 3 -- us2k10--------
rs42519551,2
C,F,H--113387523(+) ACAAAG/ATTGAC 3 -- us2k122Minor allele frequency- A:0.03NS EA NA WA 2100
rs1829478051,2
--113387556(+) CAAATC/GTAGTT 3 -- us2k10--------

HapMap Linkage Disequilibrium report for IL1RN (113864791 - 113891593 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for IL1RN:    About this table     
Variant IDTypeSubtypePubMed ID
esv2720549CNV Deletion23290073
esv995178CNV Deletion20482838
nsv874895CNV Loss21882294
nsv508102CNV Loss20534489
nsv874896CNV Loss21882294


Human Gene Mutation Database (HGMD): IL1RN
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL1RN
DNA2.0 Custom Variant and Variant Library Synthesis for IL1RN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147679   
OMIM disorders: 137215  612628  612852  
UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510
  • Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in
    numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic
    nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major
    cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased
    tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin
    and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term
    autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked
    inflammation without significant levels of autoantibodies and autoreactive T-cells. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/306 diseases for IL1RN (see all 306):    About MalaCards
    polymyalgia rheumatica    osteoporotic fracture    deficiency of interleukin-1 receptor antagonist    microvascular complications of diabetes 4
    gastric cancer risk after h. pylori infection    dengue shock syndrome    pars planitis    hyper-igd syndrome
    h. pylori infection    duodenal ulcer    generalized pustular psoriasis    nephropathia epidemica
    cryopyrin-associated periodic syndrome    pouchitis    gastritis    atrophic gastritis
    silicosis    vulvar vestibulitis syndrome    joint disorders    schnitzler syndrome

    8 diseases from the University of Copenhagen DISEASES database for IL1RN:
    Arthritis     Schnitzler syndrome     Exanthem     Inflammatory bowel disease
    Vascular disease     Hypersensitivity reaction type II disease     Mevalonic aciduria     Gastritis

    IL1RN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for IL1RN gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 79.6 380 15869054 (3), 18484235 (2), 19334038 (2), 9215253 (2) (see all 99)
    inflammation 71.9 141 1825745 (4), 8583293 (4), 1535326 (3), 8144001 (3) (see all 98)
    rheumatoid arthritis 69.9 91 15201942 (2), 11477478 (2), 16885604 (2), 7881833 (2) (see all 76)
    arthritis 60.8 73 10088773 (4), 10381034 (3), 1834576 (3), 18500247 (2) (see all 45)
    tumors 58.2 330 14598359 (6), 16354598 (5), 16489061 (5), 8362978 (4) (see all 99)
    systemic inflammatory response syndrome 55.7 14 8124953 (3), 8605344 (3), 8595517 (1), 8379462 (1) (see all 9)
    colitis ulcerative 52.2 55 8723412 (6), 10321759 (6), 8680901 (4), 11247888 (4) (see all 26)
    response acute phase 51 6 7693853 (1), 9448589 (1), 11180114 (1), 14685103 (1) (see all 6)
    osteoarthritis 50.9 24 20131253 (2), 11850718 (2), 11007768 (1), 15880595 (1) (see all 21)
    sepsis 50.2 58 8928768 (4), 10382785 (3), 9788457 (3), 15836820 (2) (see all 39)

    Genetic Association Database (GAD): IL1RN
    Human Genome Epidemiology (HuGE) Navigator: IL1RN (688 documents)

    Export disorders for IL1RN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1RN gene, integrated from 9 sources (see all 1921):
    (articles sorted by number of sources associating them with IL1RN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [The distribution of gene polymorphisms in the intron 2 and exon 2 of interleukin-1 receptor antagonist and their correlation with the serum lipoprotein level] (PubMed id 15231136)1, 4, 9 Xu P....Li G.S. (2004)
    2. A functional interleukin-1 receptor antagonist polymo rphism influences atherosclerosis development. The interleukin-1beta:interleuki n-1 receptor antagonist balance in atherosclerosis. (PubMed id 19574724)1, 4, 9 Olofsson P.S....SirsjAP A. (2009)
    3. Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis. (PubMed id 12775358)1, 4, 9 Schrijver H.M....Uitdehaag B.M. (2003)
    4. Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. (PubMed id 7629520)1, 2, 9 Muzio M.... Colotta F. (1995)
    5. Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis. (PubMed id 14735144)1, 4, 9 Carter M.J....di Giovine F.S. (2004)
    6. Interleukin-1 receptor antagonist gene polymorphism, vaginal interleukin-1 receptor antagonist concentrations, and vaginal ureaplasma urealyticum colonization in pregnant women. (PubMed id 12496176)1, 4, 9 Barton P.T....Witkin S.S. (2003)
    7. Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1beta and interleukin-1 receptor antagonist and pregnancy outcome. (PubMed id 14634579)1, 4, 9 Witkin S.S....Gerber S. (2003)
    8. Breast cancer risk associated with polymorphisms of I L-1RN and IL-4 gene in Indian women. (PubMed id 19544973)1, 4, 9 Konwar R....Bid H.K. (2009)
    9. Association of IL-4 and IL-1RN (receptor antagonist) gene variants and the risk of type 2 diabetes mellitus: A study in the north Indian population. (PubMed id 18688110)1, 4, 9 Bid H.K....Banerjee M. (2008)
    10. IL1RN intron 2 polymorphism caused by variable number tandem repeats is associated with 1-year outcome in patients with ischaemic stroke. (PubMed id 16980335)1, 4, 9 Gromadzka G....Czlonkowska A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3557 HGNC: 6000 AceView: IL1RN Ensembl:ENSG00000136689 euGenes: HUgn3557
    ECgene: IL1RN H-InvDB: IL1RN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1RN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL1RN Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: IL-1rahttp://www.rndsystems.com/molecule_detail.aspx?m=1637
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1rn/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1RN
    Kineret professional medical information"http://www.rxlist.com/kineret-drug.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL1RN gene:
    Search GeneIP for patents involving IL1RN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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