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Aliases for IL1RN Gene

Aliases for IL1RN Gene

  • Interleukin 1 Receptor Antagonist 2 3
  • Interleukin-1 Receptor Antagonist Protein 2 3
  • IL1 Inhibitor 3 4
  • ICIL-1RA 3 4
  • IL-1RN 3 4
  • IL-1ra 3 4
  • MVCD4 3 6
  • IL1F3 3 4
  • IL1RA 3 4
  • DIRA 3 6
  • IRAP 3 4
  • Intracellular Interleukin-1 Receptor Antagonist (IcIL-1ra) 3
  • Intracellular Interleukin-1 Receptor Antagonist 2
  • Intracellular IL-1 Receptor Antagonist Type II 3
  • Type II Interleukin-1 Receptor Antagonist 3
  • IL1RN (IL1F3) 3
  • Anakinra 4
  • IL-1ra3 3

External Ids for IL1RN Gene

Summaries for IL1RN Gene

Entrez Gene Summary for IL1RN Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RN Gene

IL1RN (Interleukin 1 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL1RN include microvascular complications of diabetes 4 and gastric cancer risk after h. pylori infection. Among its related pathways are Interferon Signaling and SIDS Susceptibility Pathways. GO annotations related to this gene include interleukin-1 receptor binding and interleukin-1, Type I receptor binding. An important paralog of this gene is IL37.

UniProtKB/Swiss-Prot for IL1RN Gene

  • Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Gene Wiki entry for IL1RN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RN Gene

Genomics for IL1RN Gene

Genomic Location for IL1RN Gene

113,107,214 bp from pter
113,134,016 bp from pter
26,803 bases
Plus strand

Genomic View for IL1RN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1RN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RN Gene

Regulatory Elements for IL1RN Gene

Proteins for IL1RN Gene

  • Protein details for IL1RN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-1 receptor antagonist protein
    Protein Accession:
    Secondary Accessions:
    • A8K4G1
    • Q14628
    • Q53SC2
    • Q7RTZ4
    • Q96GD6
    • Q9UPC0

    Protein attributes for IL1RN Gene

    177 amino acids
    Molecular mass:
    20055 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL1RN Gene

    Alternative splice isoforms for IL1RN Gene


neXtProt entry for IL1RN Gene

Proteomics data for IL1RN Gene at MOPED

Post-translational modifications for IL1RN Gene

Other Protein References for IL1RN Gene

No data available for DME Specific Peptides for IL1RN Gene

Domains for IL1RN Gene

Gene Families for IL1RN Gene

  • ENDOLIG :Endogenous ligands
  • IL :Interleukins and interleukin receptors

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL1RN: view

No data available for UniProtKB/Swiss-Prot for IL1RN Gene

Function for IL1RN Gene

Molecular function for IL1RN Gene

GENATLAS Biochemistry: interleukin 1,receptor antagonist,with a secreted and an alternatively spliced intracellular form
UniProtKB/Swiss-Prot Function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Gene Ontology (GO) - Molecular Function for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding IDA 2137200
GO:0005150 interleukin-1, Type I receptor binding IPI 1828071
GO:0005151 interleukin-1, Type II receptor binding IPI 1830582
GO:0005152 interleukin-1 receptor antagonist activity TAS 7629520
genes like me logo Genes that share ontologies with IL1RN: view
genes like me logo Genes that share phenotypes with IL1RN: view

Animal Models for IL1RN Gene

MGI Knock Outs for IL1RN:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL1RN Gene

Localization for IL1RN Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RN Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

Jensen Localization Image for IL1RN Gene COMPARTMENTS Subcellular localization image for IL1RN gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 4
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 10443688
GO:0005622 intracellular NAS 7629520
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IL1RN: view

Pathways for IL1RN Gene

genes like me logo Genes that share pathways with IL1RN: view

Pathways by source for IL1RN Gene

1 R&D Systems pathway for IL1RN Gene
1 Cell Signaling Technology pathway for IL1RN Gene

Gene Ontology (GO) - Biological Process for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001660 fever generation IEA --
GO:0001960 negative regulation of cytokine-mediated signaling pathway IDA 2137200
GO:0002439 chronic inflammatory response to antigenic stimulus IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006953 acute-phase response IDA 9185517
genes like me logo Genes that share ontologies with IL1RN: view

Compounds for IL1RN Gene


Pharmaceutical: Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis

(120) Novoseek inferred chemical compound relationships for IL1RN Gene

Compound -log(P) Hits PubMed IDs
anakinra 82.8 37
endotoxin 66.3 60
il 10 62.6 24
cellulose triacetate 46.5 5
neopterin 46.2 16
genes like me logo Genes that share compounds with IL1RN: view

Transcripts for IL1RN Gene

Unigene Clusters for IL1RN Gene

Interleukin 1 receptor antagonist:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for IL1RN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL1RN Gene

mRNA expression in normal human tissues for IL1RN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RN Gene

This gene is overexpressed in Esophagus - Mucosa (25.2), Minor Salivary Gland (6.9), Vagina (4.3), and Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL1RN Gene

SOURCE GeneReport for Unigene cluster for IL1RN Gene Hs.81134

mRNA Expression by UniProt/SwissProt for IL1RN Gene

Tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells
genes like me logo Genes that share expressions with IL1RN: view

Orthologs for IL1RN Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL1RN 35
  • 99.06 (n)
  • 98.87 (a)
IL1RN 36
  • 99 (a)
(Bos Taurus)
Mammalia IL1RN 35
  • 82.35 (n)
  • 78.24 (a)
IL1RN 36
  • 71 (a)
(Canis familiaris)
Mammalia IL1RN 35
  • 84.47 (n)
  • 79.55 (a)
IL1RN 36
  • 72 (a)
(Mus musculus)
Mammalia Il1rn 35
  • 81.17 (n)
  • 76.27 (a)
Il1rn 16
Il1rn 36
  • 67 (a)
(Monodelphis domestica)
Mammalia IL1RN 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia IL1RN 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Il1rn 35
  • 78.53 (n)
  • 74.01 (a)
(Gallus gallus)
Aves IL1B 35
  • 57.42 (n)
  • 44.53 (a)
Species with no ortholog for IL1RN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1RN Gene

Gene Tree for IL1RN (if available)
Gene Tree for IL1RN (if available)

Paralogs for IL1RN Gene

Paralogs for IL1RN Gene

Selected SIMAP similar genes for IL1RN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL1RN: view

Variants for IL1RN Gene

Sequence variations from dbSNP and Humsavar for IL1RN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9005 -- 113,133,835(+) CCACC(A/G)GGCTG utr-variant-3-prime
rs16065 -- 113,118,054(+) TTTTT(C/T)CACCT intron-variant
rs128964 -- 113,130,226(+) TTTTC(A/G)CTCCC intron-variant
rs315919 -- 113,118,636(-) TTATA(A/C)TTTAA intron-variant, upstream-variant-2KB
rs315934 -- 113,126,129(-) ACACT(A/G)TTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL1RN Gene

Variant ID Type Subtype PubMed ID
nsv874895 CNV Loss 21882294
nsv508102 CNV Loss 20534489
nsv874896 CNV Loss 21882294
esv995178 CNV Deletion 20482838
esv2720549 CNV Deletion 23290073

Relevant External Links for IL1RN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RN Gene

Disorders for IL1RN Gene

(3) OMIM Diseases for IL1RN Gene (147679)


  • Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. {ECO:0000269 PubMed:19494218}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(98) Novoseek inferred disease relationships for IL1RN Gene

Disease -log(P) Hits PubMed IDs
necrosis 79.6 106
inflammation 71.9 127
rheumatoid arthritis 69.9 85
arthritis 60.8 61
tumors 58.2 127

Relevant External Links for IL1RN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL1RN: view

Publications for IL1RN Gene

  1. Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. (PMID: 7629520) Muzio M. … Colotta F. (J. Exp. Med. 1995) 3 4 23
  2. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. (PMID: 2139180) Carter D.B. … Tracey D.E. (Nature 1990) 3 4 23
  3. Detection of an interleukin-1 intracellular receptor antagonist mRNA variant. (PMID: 9514884) Weissbach L. … Towle C.A. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  4. Lack of association between interleukin-1 receptor antagonist protein gene polymorphism and bone mineral density in Hungarian postmenopausal women. (PMID: 11033452) Bajnok E. … Lakatos P. (Bone 2000) 3 23 48
  5. Polymorphism in the interleukin-1 receptor antagonist gene is associated with alcoholism in Spanish men. (PMID: 11045853) Pastor I.J. … GonzA!lez-Sarmiento R. (Alcohol. Clin. Exp. Res. 2000) 3 23 48

Products for IL1RN Gene

Sources for IL1RN Gene

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