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Aliases for IL1RN Gene

Aliases for IL1RN Gene

  • Interleukin 1 Receptor Antagonist 2 3 5
  • IL1 Inhibitor 3 4
  • ICIL-1RA 3 4
  • IL-1RN 3 4
  • IL-1ra 3 4
  • IL1RA 3 4
  • IL1F3 3 4
  • IRAP 3 4
  • Intracellular Interleukin-1 Receptor Antagonist (IcIL-1ra) 3
  • Intracellular Interleukin-1 Receptor Antagonist 2
  • Intracellular IL-1 Receptor Antagonist Type II 3
  • Interleukin-1 Receptor Antagonist Protein 2
  • Type II Interleukin-1 Receptor Antagonist 3
  • Anakinra 4
  • IL-1ra3 3
  • MVCD4 3
  • DIRA 3

External Ids for IL1RN Gene

Previous GeneCards Identifiers for IL1RN Gene

  • GC02P111081
  • GC02P111796
  • GC02P113782
  • GC02P113970
  • GC02P113591
  • GC02P113864
  • GC02P106329

Summaries for IL1RN Gene

Entrez Gene Summary for IL1RN Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]

GeneCards Summary for IL1RN Gene

IL1RN (Interleukin 1 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL1RN include interleukin 1 receptor antagonist deficiency and microvascular complications of diabetes 4. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. An important paralog of this gene is IL37.

UniProtKB/Swiss-Prot for IL1RN Gene

  • Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Gene Wiki entry for IL1RN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RN Gene

Genomics for IL1RN Gene

Regulatory Elements for IL1RN Gene

Genomic Location for IL1RN Gene

Chromosome:
2
Start:
113,099,365 bp from pter
End:
113,134,016 bp from pter
Size:
34,652 bases
Orientation:
Plus strand

Genomic View for IL1RN Gene

Genes around IL1RN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RN Gene

Proteins for IL1RN Gene

  • Protein details for IL1RN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18510-IL1RA_HUMAN
    Recommended name:
    Interleukin-1 receptor antagonist protein
    Protein Accession:
    P18510
    Secondary Accessions:
    • A8K4G1
    • Q14628
    • Q53SC2
    • Q7RTZ4
    • Q96GD6
    • Q9UPC0

    Protein attributes for IL1RN Gene

    Size:
    177 amino acids
    Molecular mass:
    20055 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL1RN Gene

    Alternative splice isoforms for IL1RN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1RN Gene

Proteomics data for IL1RN Gene at MOPED

Post-translational modifications for IL1RN Gene

  • Glycosylation at Asn 109
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IL1RN (IL-1ra/IL-1F3)
  • Cell Signaling Technology (CST) Antibodies for IL1RN (IL1RN)

No data available for DME Specific Peptides for IL1RN Gene

Domains & Families for IL1RN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL1RN: view

No data available for UniProtKB/Swiss-Prot for IL1RN Gene

Function for IL1RN Gene

Molecular function for IL1RN Gene

GENATLAS Biochemistry:
interleukin 1,receptor antagonist,with a secreted and an alternatively spliced intracellular form
UniProtKB/Swiss-Prot Function:
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Gene Ontology (GO) - Molecular Function for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005151 interleukin-1, Type II receptor binding IPI 1830582
genes like me logo Genes that share ontologies with IL1RN: view
genes like me logo Genes that share phenotypes with IL1RN: view

Human Phenotype Ontology for IL1RN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL1RN Gene

MGI Knock Outs for IL1RN:

Animal Model Products

miRNA for IL1RN Gene

miRTarBase miRNAs that target IL1RN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL1RN Gene

Localization for IL1RN Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RN Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1RN Gene COMPARTMENTS Subcellular localization image for IL1RN gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IDA 2137200
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with IL1RN: view

Pathways & Interactions for IL1RN Gene

genes like me logo Genes that share pathways with IL1RN: view

Pathways by source for IL1RN Gene

Gene Ontology (GO) - Biological Process for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006953 acute-phase response IDA 9185517
GO:0030073 insulin secretion IEA --
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway IDA 2137200
genes like me logo Genes that share ontologies with IL1RN: view

No data available for SIGNOR curated interactions for IL1RN Gene

Drugs & Compounds for IL1RN Gene

(67) Drugs for IL1RN Gene - From: Novoseek, DGIdb, PharmGKB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rilonacept Approved Pharma Target, binder 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
AC-201 Pharma 0

(56) Additional Compounds for IL1RN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL1RN: view

Transcripts for IL1RN Gene

Unigene Clusters for IL1RN Gene

Interleukin 1 receptor antagonist:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - -
SP9:
SP10:

Relevant External Links for IL1RN Gene

GeneLoc Exon Structure for
IL1RN
ECgene alternative splicing isoforms for
IL1RN

Expression for IL1RN Gene

mRNA expression in normal human tissues for IL1RN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RN Gene

This gene is overexpressed in Esophagus - Mucosa (x25.2), Minor Salivary Gland (x6.9), Vagina (x4.3), and Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for IL1RN Gene

This gene is overexpressed in Cervix (38.6), Saliva (9.9), and Esophagus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL1RN Gene



SOURCE GeneReport for Unigene cluster for IL1RN Gene Hs.81134

mRNA Expression by UniProt/SwissProt for IL1RN Gene

P18510-IL1RA_HUMAN
Tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells.
genes like me logo Genes that share expression patterns with IL1RN: view

Protein tissue co-expression partners for IL1RN Gene

- Elite partner

In Situ Assay Products

Orthologs for IL1RN Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1RN 35
  • 99.06 (n)
  • 98.87 (a)
IL1RN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL1RN 36
  • 71 (a)
OneToOne
IL1RN 35
  • 82.35 (n)
  • 78.24 (a)
dog
(Canis familiaris)
Mammalia IL1RN 35
  • 84.47 (n)
  • 79.55 (a)
IL1RN 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1rn 36
  • 67 (a)
OneToOne
Il1rn 16
Il1rn 35
  • 81.17 (n)
  • 76.27 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1RN 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RN 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1rn 35
  • 78.53 (n)
  • 74.01 (a)
chicken
(Gallus gallus)
Aves IL1B 35
  • 57.42 (n)
  • 44.53 (a)
Species with no ortholog for IL1RN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1RN Gene

ENSEMBL:
Gene Tree for IL1RN (if available)
TreeFam:
Gene Tree for IL1RN (if available)

Paralogs for IL1RN Gene

Paralogs for IL1RN Gene

(2) SIMAP similar genes for IL1RN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL1RN: view

Variants for IL1RN Gene

Sequence variations from dbSNP and Humsavar for IL1RN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs45507693 - 113,132,707(+) GCTTC(A/G)CCTTC reference, missense
rs9005 -- 113,133,835(+) CCACC(A/G)GGCTG utr-variant-3-prime
rs315919 -- 113,118,636(-) TTATA(A/C)TTTAA intron-variant
rs315920 -- 113,115,441(+) TGCTC(C/T)TCCAT intron-variant
rs315921 -- 113,114,474(-) ACTCA(C/T)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RN Gene

Variant ID Type Subtype PubMed ID
nsv874895 CNV Loss 21882294
nsv508102 CNV Loss 20534489
nsv874896 CNV Loss 21882294
esv995178 CNV Deletion 20482838
esv2720549 CNV Deletion 23290073

Variation tolerance for IL1RN Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RN Gene

HapMap Linkage Disequilibrium report
IL1RN
Human Gene Mutation Database (HGMD)
IL1RN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RN Gene

Disorders for IL1RN Gene

MalaCards: The human disease database

(85) MalaCards diseases for IL1RN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
interleukin 1 receptor antagonist deficiency
  • interleukin-1 receptor antagonist
microvascular complications of diabetes 4
  • diabetic nephropathy
gastric cancer risk after h. pylori infection
  • gastric cancer, somatic
adult-onset still's disease
  • adult onset still's disease
schnitzler syndrome
  • chronic urticaria with gammapathy
- elite association - COSMIC cancer census association via MalaCards
Search IL1RN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL1RA_HUMAN
  • Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269 PubMed:8786086}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. {ECO:0000269 PubMed:19494218}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL1RN

Genetic Association Database (GAD)
IL1RN
Human Genome Epidemiology (HuGE) Navigator
IL1RN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1RN
genes like me logo Genes that share disorders with IL1RN: view

No data available for Genatlas for IL1RN Gene

Publications for IL1RN Gene

  1. [The distribution of gene polymorphisms in the intron 2 and exon 2 of interleukin-1 receptor antagonist and their correlation with the serum lipoprotein level]. (PMID: 15231136) Xu P. … Li G.S. (Zhonghua Liu Xing Bing Xue Za Zhi 2004) 3 23 48 67
  2. Uncovering an IL-10-dependent NF-kappaB recruitment to the IL-1ra promoter that is impaired in STAT3 functionally defective patients. (PMID: 20032313) Tamassia N. … Bazzoni F. (FASEB J. 2010) 3 23
  3. Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population. (PMID: 20188863) Taype C.A. … Shaw M.A. (Infect. Genet. Evol. 2010) 3 23
  4. An autoinflammatory disease with deficiency of the interleukin-1- receptor antagonist. (PMID: 19494218) Aksentijevich I. … Goldbach-Mansky R. (N. Engl. J. Med. 2009) 3 23
  5. Breast cancer risk associated with polymorphisms of IL-1RN and IL-4 gene in Indian women. (PMID: 19544973) Konwar R. … Bid H.K. (Oncol. Res. 2009) 3 23

Products for IL1RN Gene

Sources for IL1RN Gene

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