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IL1RN Gene

protein-coding GIFtS: 63

GC02P113591

interleukin 1 receptor antagonist
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Anakinra ^³
ICIL-1RA ^¹, ², ³
IL-1RN ^³
IL-1ra ^³
IL-1ra3 ^²
IL1F3 ^¹, ², ³
IL1RA ^¹, ², ³
IRAP ^¹, ², ³
MGC10430 ^²

Descriptions
IL1 inhibitor ^³
IL1RN (IL1F3) ^²
interleukin 1 receptor antagonist ^²
intracellular IL-1 receptor antagonist type II ^²
intracellular interleukin-1 receptor antagonist (icIL-1ra) ^²
type II interleukin-1 receptor antagonist ^²

External Ids
HGNC: 6000¹
Entrez Gene: 3557²
UniProtKB: P18510³
Ensembl: ENSG00000136689⁷

Search outside databases for aliases for IL1RN gene

Previous GC identifers: GC02P111081 GC02P111796 GC02P113782 GC02P113970

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IL1RN:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein

inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and

modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five

other closely related cytokine genes form a gene cluster spanning approximately 400 kb on

chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of

osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding

distinct isoforms have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510

Function: Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IL1RN gene

Entrez Gene cytogenetic band: 2q14.2 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q14.2

IL1RN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P113591: (about GC identifiers)

Start:	113,585,164 bp from pter
End:	113,608,064 bp from pter
Size:	22,901 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022135.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510 (See protein sequence)

Recommended Name: Interleukin-1 receptor antagonist protein precursor

Size: 177 amino acids; 20055 Da

Subcellular location: Isoform 1: Secreted

Subcellular location: Isoform 2: Cytoplasm

Subcellular location: Isoform 3: Cytoplasm

Subcellular location: Isoform 4: Cytoplasm

PDB structures from and Proteopedia :

1ILR (3D)

1ILT (3D)

1IRA (3D)

1IRP (3D)

1ITN (3D)

2IRT (3D)

Secondary accessions: Q14628 Q7RTZ4 Q96GD6 Q9UPC0

Alternative splicing: 4 isoforms: P18510-1 P18510-2 P18510-3 P18510-4

REFSEQ proteins (4 alternative transcripts):

NP_000568.1 NP_776213.1 NP_776214.1 NP_776215.1

ENSEMBL proteins:

ENSP00000329072 ENSP00000259206 ENSP00000387173 ENSP00000354816 ENSP00000387210

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IL1RN (IL-1ra/IL-1F3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IL1RA antagonist)
	Human Recombinant Proteins from Abnova (IL1RN)

OriGene Purified Recombinant Human Proteins (see all 2): IL1RN

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	1385987
GO:0005622	intracellular	NAS	7629520
GO:0005737	cytoplasm	IEA	--

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Antibodies for IL1RN:

	Invitrogen Antibodies for IL1RN
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IL1RN
	R&D Systems Antibodies for IL1RN (IL-1ra/IL-1F3)
	Cell Signaling Technology (CST) Antibodies for IL1RN (IL-1RA)
	Antibodies from Abcam (IL1RA antagonist), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IL1RN)
	Novus Biologicals Antibodies for IL1RN

Assays for IL1RN:

	Invitrogen Assays for IL1RN
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for IL1RN (IL-1ra/IL-1F3) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18510

ProtoNet protein and cluster: P18510

2 Blocks protein families:

IPB000975 Interleukin-1 precursor family signature

IPB003297 Interleukin-1 receptor antagonist precursor IL-1RA signature

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL1RN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL1RN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000577

Applied Biosystems Silencer® siRNAs for IL1RN

Sigma-Aldrich siRNA and siRNA Panels for IL1RN

Sigma-Aldrich shRNA Panels and shRNA for IL1RN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IL1RN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000577
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000577
untagged cDNA clones in CMV expression vector (see all 4): NM_000577

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173841

UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510

Function: Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity

Genatlas biochemistry entry for IL1RN:

interleukin 1,receptor antagonist,with a secreted and an alternatively spliced intracellular form

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Il1rn):

	growth/size	hematopoietic system	homeostasis/metabolism	immune system
life span-post-weaning/aging	reproductive system	skeleton	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	NAS	10443688
GO:0005152	interleukin-1 receptor antagonist activity	TAS	7629520
GO:0005515	protein binding	IPI	9062194

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for IL1RN (Your Favorite Gene powered by Ingenuity) (see all 14 )

FXR/RXR Activation
p38 MAPK Signaling
LXR/RXR Activation
Hepatic Cholestasis
IL-6 Signaling

GeneDecks IL1RN for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IL1RN

5/48 Interacting proteins for IL1RN (ENSP00000259206³ P18510^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 48 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL1R1	P14778¹^,²	STRING (score=.999) EBI-1026330, EBI-525905 MINT-25085 EBI-1026330, EBI-525905 MINT-25085
IL1R1	P14778¹^,²	STRING (score=.999) EBI-1026330, EBI-525905 MINT-25085 EBI-1026330, EBI-525905 MINT-25085
IL1R2	ENSP00000330959³	STRING (score=.997)
IL8	ENSP00000306512³	STRING (score=.975)
IL1A	ENSP00000263339³	STRING (score=.966)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IDA	10443688
GO:0006955	immune response	NAS	7629520
GO:0051384	response to glucocorticoid stimulus	IDA	10443688

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IL1RN
UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510

Pharmaceutical: Available under the name Kineret (Amgen). Used for the reduction in signs and

symptoms and slowing the progression of structural damage in moderately to severely active

rheumatoid arthritis

10/53 Novoseek chemical compound relationships for IL1RN gene (see all 53 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
endotoxin	66.93	70	11900341 (3), 8219190 (3), 8299563 (2), 7714108 (2) (see all 48)
il 10	58.41	23	18339663 (5), 18832862 (3), 16842617 (2), 16905295 (2) (see all 13)
cellulose triacetate	48.18	6	7890436 (4), 9355078 (1)
neopterin	45.61	18	16273760 (2), 9060965 (2), 8528884 (2), 7814891 (2) (see all 11)
rantes	43.74	18	15645140 (2), 9215253 (2), 16078996 (2), 18225444 (1) (see all 13)
polysulfone	43.21	6	11775226 (3), 15814541 (1), 12784048 (1)
2-chloroethyl ethyl sulfide	37.06	1	11031321 (1)
cuprophan	36.06	8	7890436 (3), 7619385 (1), 10857769 (1), 10879665 (1)
leukotriene b4	33.23	17	15320881 (3), 8205398 (2), 1330330 (1), 1535326 (1) (see all 10)
tsst	25.74	1	15325407 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL1RN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL1RN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000577

Sigma-Aldrich siRNA and siRNA Panels for IL1RN

Sigma-Aldrich shRNA Panels and shRNA for IL1RN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000577 NM_173841 NM_173842 NM_173843

REFSEQ mRNAs for IL1RN gene (4 alternative transcripts):

NM_000577.3 NM_173841.1 NM_173842.1 NM_173843.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000577 NM_173841 NM_173842 NM_173843

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000577
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000577
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000577

Additional cDNA sequence:

AF043143.1 AJ005835.1 AK290898.1 AK290926.1 BC009745.2 BC068441.1 CR605915.1 CR606622.1

CR616671.1 CR619093.1 CR625646.1 M55646.1 X52015.1 X53296.1 X84348.1

11 DOTS entries:

DT.445015 DT.95299944 DT.100036266 DT.100734138 DT.100822280 DT.95313026 DT.75180886 DT.120938278

DT.75195163 DT.92427796 DT.95082557

24/157 AceView cDNA sequences (see all 157 ):

CD370507 AA497140 X84348 BU608443 CR616671 AF043143 BM978858 CA309172

AW272661 CD368886 CR619093 BI335900 CR625646 AI983971 CB305886 CA307165

AJ005835 M55646 CR606622 BU626944 CR605915 BC068441 BE504650 AI814526

highest scoring ESTs for IL1RN:

AA195304 AA327613 AA497054 AA497064 AA497131 AA497140 AA704518 AA808207 AA835355 AA877799

Unigene Cluster for IL1RN:

Interleukin 1 receptor antagonist

Hs.81134 [show with all ESTs]

Unigene Representative Sequence: BC068441

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IL1RN (see all 10 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	^	8
SP1:											-		-		-						-		-		-
SP2:							-				-		-		-						-		-		-
SP3:											-		-		-						-		-		-
SP4:									-		-		-		-						-		-		-
SP5:							-		-		-		-		-						-		-		-

About this scheme

ECgene alternative splicing isoforms for IL1RN

5 Ensembl transcripts including schematic representations:

ENST00000354115 ENST00000259206 ENST00000409930 ENST00000361779 ENST00000409052

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IL1RN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IL1RN

¹ / ² / ³

10 probe-sets matching IL1RN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37603_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X52015	0.80	1.00	0.91	1
31343_at²^{, 3}	U95-A	1	1.00	1.00	-0.30	0.30	AJ005835	0.60	1.00	0.82	1
212659_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW083357	0.80	1.00	0.91	1
212657_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
216243_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE563442	0.60	1.00	0.82	1
216244_at²^{, 3}	U133-A	1	0.82	1.00	--	--	BE563442	0.60	1.00	0.82	1
212659_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212657_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216243_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216244_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks IL1RN for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCTGGATCC

SOURCE GeneReport for Unigene cluster: Hs.81134
UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510
Tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL1RN gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL1RN¹	--	interleukin 1 receptor antagonist	84.28(n) 79.55(a)	403660 NM_001003096.1 NP_001003096.1
chimpanzee (Pan troglodytes)	IL1RN¹	--	interleukin 1 receptor antagonist	99.25(n) 98.87(a)	459501 XM_001147954.1 XP_001147954.1
cow (Bos taurus)	IL1RN¹	--	interleukin 1 receptor antagonist	82.55(n) 78.24(a)	281860 NM_174357.2 NP_776782.1
rat (Rattus norvegicus)	Il1rn¹	--	interleukin 1 receptor antagonist	78.53(n) 74.01(a)	60582 NM_022194.2 NP_071530.1
mouse (Mus musculus)	Il1rn^{1, 5}	2 (10.00 cM)⁵	interleukin 1 receptor antagonist^{1, 5}	81.17(n)¹ 76.27(a)¹	16181¹ NM_001039701.2¹ NP_001034790.1¹ AF001795⁵ AK076296⁵ (see all 31)

About this table Species with no ortholog for IL1RN

ENSEMBL Gene Tree for IL1RN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for IL1RN gene

IL1F6² IL1F9² IL1F5² IL1F7² IL1F10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/286 NCBI SNPs in IL1RN are shown (see all 286 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 140)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs396201^1,2	A,C,F,H	113608246(+)	`AAAGAC/TATGGG`	4	--	ng3¹		15	NS EU EA WA NA MN	1670
	rs9005^1,2	A,C,F,H	113607883(+)	`ccaccG/Aggctg`	4	--	ut3¹ ese³		18	MN EU EA WA NS NA	2174
	rs315951^1,2	A,C,F,H	113607057(-)	`AGGTTC/GTTGTG`	4	--	ut3¹ ese³		22	EA NA NS MN EU WA	2037
	rs315950^1,2	A,C,F,H	113608276(-)	`tccagT/Cagagg`	4	--	ng3¹		6	NS EU EA WA	510
--	rs4251967^1,2	A,C,F,H	113591439(+)	`agagaG/Cggctt`	3	--	ng5¹		6	NS EU EA WA	500
	rs4251955^1,2	C,F,H	113590342(+)	`ACAAAG/ATTGAC`	3	--	ng5¹		16	NS EU EA WA	1584
	rs4252041^1,2	C,F,H	113607081(+)	`TGCCTC/TCTCTT`	4	--	ut3¹ ese³ trp³		21	NS EU EA WA NA MN	3182
	rs3087262^1,2	A,C,F	113600673(+)	`TATCAC/GAGCCC`	4	--	int¹ ng5¹		3	NA NS	134
--	rs439154^1,2	A,C,F	113600872(+)	`GCAGAA/GGTTGA`	4	--	int¹ ng5¹		3	NA NS	134
--	rs4252001^1,2	C,F,H	113600154(+)	`CCATCA/GTTTTT`	4	--	int¹ ng5¹		10	NS EU EA WA	906

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HapMap Linkage Disequilibrium images for IL1RN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 147679 disorders: 137215

UniProtKB/Swiss-Prot: IL1RA_HUMAN, P18510

Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy

[MIM:612628]; also called susceptibility to microvascular complications of diabetes type 4

(MVCD4). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to

the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features

include increased urine protein and declining kidney function

10/97 Novoseek disease relationships for IL1RN gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	79.36	363	15869054 (3), 18484235 (2), 9215253 (2), 14715179 (2) (see all 99)
inflammation	71.40	140	1825745 (4), 8583293 (4), 1535326 (3), 8144001 (3) (see all 97)
rheumatoid arthritis	69.74	89	15201942 (2), 11477478 (2), 16885604 (2), 7881833 (2) (see all 74)
arthritis	61.05	72	10088773 (4), 10381034 (3), 1834576 (3), 18500247 (2) (see all 45)
tumors	57.39	315	14598359 (6), 16354598 (5), 16489061 (5), 8362978 (4) (see all 99)
systemic inflammatory response syndrome	57.30	14	8124953 (3), 8605344 (3), 8595517 (1), 8379462 (1) (see all 9)
colitis ulcerative	53.88	55	8723412 (6), 10321759 (6), 8680901 (4), 11247888 (4) (see all 26)
response acute phase	52.22	6	7693853 (1), 9448589 (1), 11180114 (1), 14685103 (1) (see all 6)
sepsis	50.43	58	8928768 (4), 9788457 (3), 10382785 (3), 15836820 (2) (see all 39)
osteoarthritis	49.96	22	11850718 (2), 11007768 (1), 15880595 (1), 17968946 (1) (see all 20)

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Human Gene Mutation Database: IL1RN
Genetic Association Database: IL1RN
Human Genome Epidemiology Navigator: IL1RN (514 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1566 PubMed articles for IL1RN gene (see all 1566 ):

[The distribution of gene polymorphisms in the intron 2 and exon 2 of interleukin-1 receptor antagonist and their correlation with the serum lipoprotein level] (PubMed id 15231136)^{1, 3, 6} Xu P....Li G.S. (2004)
Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. (PubMed id 7629520)^{1, 3, 4} Muzio M.... Colotta F. (1995)
Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. (PubMed id 1828896)^{1, 3, 4} Eisenberg S.P.... Thompson R.C. (1991)
Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (PubMed id 12578333)^{1, 3, 6} Chou H.T....Tsai F.J. (2003)
Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline. (PubMed id 7867645)^{1, 3, 4} Schreuder H.A.... Barrett R.W. (1995)
The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. (PubMed id 1386337)^{1, 2, 3} Steinkasserer A....Sim R.B. (1992)
[Association of different alleles in interleukin-1 family genes with the coded cytokines production and outcome of sepsis] (PubMed id 15836820)^{1, 3, 6} Yang M.S....Chen D.C. (2005)
Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (PubMed id 16284368)^{1, 3, 6} Taguchi A....Goto H. (2005)
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. (PubMed id 16098232)^{1, 3, 6} Ohashi J....Tokunaga K. (2005)
Association study of functional genetic variants of innate immunity related genes in celiac disease. (PubMed id 16078996)^{1, 3, 6} Rueda B....Koeleman B.P. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3557	HGNC: 6000	AceView: IL1RN	Ensembl:ENSG00000136689	euGenes: HUgn3557
ECgene: IL1RN	H-InvDB: IL1RN

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IL1RN	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: IL-1ra	http://www.rndsystems.com/molecule_detail.aspx?m=1637
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_1
SeattleSNPs	http://pga.gs.washington.edu/data/il1rn/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1RN
Kineret professional medical information"	http://www.kineretrx.com/professional/

Licensable Technologies for IL1RN
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IL1RN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IL1RN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IL1RN		Antibodies for IL1RN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IL1RN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IL1RN)
	Antibodies (IL1RN)
	Chimera RNAi (IL1RN)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for IL1RN (IL-1RA)

	Recombinant Proteins (IL1RA antagonist)
	Antibodies (IL1RA antagonist)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for IL1RN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IL1RN

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IL1RN Gene at Home site.
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IL1RN Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for IL1RN

Summaries
for IL1RN

Genomic Location
for IL1RN

Proteins
for IL1RN

Protein Domains/
Families
for IL1RN

Gene Function
for IL1RN

Pathways & Interactions
for IL1RN

Drugs & Compounds
for IL1RN

Transcripts
for IL1RN

Expression
for IL1RN

Orthologs
for IL1RN

Paralogs
for IL1RN

SNPs/Variants
for IL1RN

Disorders & Mutations
for IL1RN

Medical News
for IL1RN

Publications
for IL1RN

Search for IL1RN

Genome Databases showing IL1RN

Other Databases showing IL1RN

Specialized Databases showing IL1RN

Licensable Technologies
for IL1RN

Services
for IL1RN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IL1RN Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor IL1RN

Summariesfor IL1RN

Genomic Locationfor IL1RN

Proteinsfor IL1RN

Protein Domains/Familiesfor IL1RN

Gene Functionfor IL1RN

Pathways & Interactionsfor IL1RN

Drugs & Compoundsfor IL1RN

Transcriptsfor IL1RN

Expression for IL1RN

Orthologsfor IL1RN

Paralogsfor IL1RN

SNPs/Variantsfor IL1RN

Disorders & Mutationsfor IL1RN

Medical Newsfor IL1RN

Publicationsfor IL1RN

Search for IL1RN

Genome Databases showing IL1RN

Other Databases showing IL1RN

Specialized Databases showing IL1RN

Licensable Technologiesfor IL1RN

Servicesfor IL1RN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IL1RN

Summaries
for IL1RN

Genomic Location
for IL1RN

Proteins
for IL1RN

Protein Domains/
Families
for IL1RN

Gene Function
for IL1RN

Pathways & Interactions
for IL1RN

Drugs & Compounds
for IL1RN

Transcripts
for IL1RN

Expression
for IL1RN

Orthologs
for IL1RN

Paralogs
for IL1RN

SNPs/Variants
for IL1RN

Disorders & Mutations
for IL1RN

Medical News
for IL1RN

Publications
for IL1RN

Licensable Technologies
for IL1RN

Services
for IL1RN