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Aliases for IL1RN Gene

Aliases for IL1RN Gene

  • Interleukin 1 Receptor Antagonist 2 3 5
  • Interleukin-1 Receptor Antagonist Protein 2 3
  • IL1 Inhibitor 3 4
  • ICIL-1RA 3 4
  • IL-1RN 3 4
  • IL-1ra 3 4
  • IL1RA 3 4
  • IL1F3 3 4
  • IRAP 3 4
  • Intracellular Interleukin-1 Receptor Antagonist (IcIL-1ra) 3
  • Intracellular Interleukin-1 Receptor Antagonist 2
  • Intracellular IL-1 Receptor Antagonist Type II 3
  • Type II Interleukin-1 Receptor Antagonist 3
  • Anakinra 4
  • IL-1ra3 3
  • MVCD4 3
  • DIRA 3

External Ids for IL1RN Gene

Previous GeneCards Identifiers for IL1RN Gene

  • GC02P111081
  • GC02P111796
  • GC02P113782
  • GC02P113970
  • GC02P113591
  • GC02P113864
  • GC02P106329
  • GC02P113107

Summaries for IL1RN Gene

Entrez Gene Summary for IL1RN Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]

GeneCards Summary for IL1RN Gene

IL1RN (Interleukin 1 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL1RN include Interleukin 1 Receptor Antagonist Deficiency and Microvascular Complications Of Diabetes 4. Among its related pathways are IL-1 signaling pathway and Innate Immune System. GO annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. An important paralog of this gene is IL36RN.

UniProtKB/Swiss-Prot for IL1RN Gene

  • Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Gene Wiki entry for IL1RN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RN Gene

Genomics for IL1RN Gene

Regulatory Elements for IL1RN Gene

Enhancers for IL1RN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G113076 1.8 FANTOM5 Ensembl ENCODE dbSUPER 71.8 -20.6 -20564 3.7 NFIB RAD21 YY1 ZNF143 FOS RCOR1 EGR2 ZNF654 ZHX2 REST IL1RN IL36B IL1B IL36A IL36RN PSD4 IL36G IL37 PAX8-AS1 IL1A
GH02G112875 1.9 FANTOM5 Ensembl ENCODE dbSUPER 47.1 -220.3 -220349 7.2 FOXA2 PKNOX1 RAD21 RARA TCF12 GATA2 EGR1 FOS ETV6 IKZF2 IL1B IL1RN IL1A IL36B IL37 IL36G CKAP2L IL36RN PIR40727 XIAPP3
GH02G112811 1.8 FANTOM5 Ensembl ENCODE dbSUPER 45.9 -286.1 -286060 4.3 PKNOX1 ATF1 GATA2 FOS JUNB TBX21 SMARCA4 MYNN ETV4 NR2C1 IL1B IL1RN IL1A IL37 IL36B IL36G CKAP2L IL36RN GC02M112788
GH02G113081 1.1 FANTOM5 dbSUPER 57.4 -17.6 -17588 0.7 SOX13 ZFP64 CEBPG ZNF48 ZNF644 TEAD3 RARA NR2F6 GATAD2A SOX5 IL1RN IL1B IL36B IL36G PAX8-AS1 PSD4 IL1A IL36RN CBWD2 GC02P113088
GH02G112799 1.6 FANTOM5 Ensembl ENCODE dbSUPER 39 -299.8 -299797 0.9 HDAC1 SMARCE1 MTA2 TAL1 JUNB FOSL1 TCF12 ARID1B EED IKZF1 IL1B IL1RN CKAP2L IL36B IL1A IL36G FLJ42351 IL36RN GC02M112788
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL1RN on UCSC Golden Path with GeneCards custom track

Genomic Location for IL1RN Gene

113,099,365 bp from pter
113,134,016 bp from pter
34,652 bases
Plus strand

Genomic View for IL1RN Gene

Genes around IL1RN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RN Gene

Proteins for IL1RN Gene

  • Protein details for IL1RN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-1 receptor antagonist protein
    Protein Accession:
    Secondary Accessions:
    • A8K4G1
    • Q14628
    • Q53SC2
    • Q7RTZ4
    • Q96GD6
    • Q9UPC0

    Protein attributes for IL1RN Gene

    177 amino acids
    Molecular mass:
    20055 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL1RN Gene

    Alternative splice isoforms for IL1RN Gene


neXtProt entry for IL1RN Gene

Post-translational modifications for IL1RN Gene

  • Glycosylation at posLast=109109
  • Modification sites at PhosphoSitePlus

Assay Products

No data available for DME Specific Peptides for IL1RN Gene

Domains & Families for IL1RN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL1RN: view

No data available for UniProtKB/Swiss-Prot for IL1RN Gene

Function for IL1RN Gene

Molecular function for IL1RN Gene

GENATLAS Biochemistry:
interleukin 1,receptor antagonist,with a secreted and an alternatively spliced intracellular form
UniProtKB/Swiss-Prot Function:
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Gene Ontology (GO) - Molecular Function for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding IEA --
GO:0005150 interleukin-1, Type I receptor binding IPI 1828071
GO:0005151 interleukin-1, Type II receptor binding IPI 1830582
GO:0005152 interleukin-1 receptor antagonist activity TAS 7629520
genes like me logo Genes that share ontologies with IL1RN: view
genes like me logo Genes that share phenotypes with IL1RN: view

Human Phenotype Ontology for IL1RN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL1RN Gene

MGI Knock Outs for IL1RN:

Animal Model Products

miRNA for IL1RN Gene

miRTarBase miRNAs that target IL1RN

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL1RN Gene

Localization for IL1RN Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RN Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1RN gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 10443688
GO:0005622 intracellular NAS 7629520
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IL1RN: view

Pathways & Interactions for IL1RN Gene

genes like me logo Genes that share pathways with IL1RN: view

Pathways by source for IL1RN Gene

Gene Ontology (GO) - Biological Process for IL1RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response NAS 7629520
GO:0030073 insulin secretion IEA --
GO:0034115 negative regulation of heterotypic cell-cell adhesion IDA 2139180
genes like me logo Genes that share ontologies with IL1RN: view

No data available for SIGNOR curated interactions for IL1RN Gene

Drugs & Compounds for IL1RN Gene

(71) Drugs for IL1RN Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rilonacept Approved Pharma Target, binder 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
Dexamethasone sodium phosphate Pharma 0
AC-201 Pharma 0

(53) Additional Compounds for IL1RN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for IL1RN Gene

Compound Action Cas Number
Dexamethasone Sodium Phosphate 55203-24-2
genes like me logo Genes that share compounds with IL1RN: view

Drug Products

Transcripts for IL1RN Gene

Unigene Clusters for IL1RN Gene

Interleukin 1 receptor antagonist:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for IL1RN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL1RN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL1RN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RN Gene

This gene is overexpressed in Esophagus - Mucosa (x25.2), Minor Salivary Gland (x6.9), Vagina (x4.3), and Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for IL1RN Gene

This gene is overexpressed in Cervix (38.6), Saliva (9.9), and Esophagus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IL1RN Gene

Protein tissue co-expression partners for IL1RN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL1RN Gene:


SOURCE GeneReport for Unigene cluster for IL1RN Gene:


mRNA Expression by UniProt/SwissProt for IL1RN Gene:

Tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells.

Evidence on tissue expression from TISSUES for IL1RN Gene

  • Bone marrow(4.5)
  • Pancreas(4.3)
  • Blood(3.2)
  • Skin(3.1)
  • Liver(2.6)
  • Lung(2.4)
  • Stomach(2.4)
  • Intestine(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RN Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • immune
  • integumentary
  • lymphatic
  • skeleton
Head and neck:
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
  • liver
  • spleen
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • bone marrow
  • hair
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with IL1RN: view

Orthologs for IL1RN Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL1RN 34 35
  • 99.06 (n)
(Canis familiaris)
Mammalia IL1RN 34 35
  • 84.47 (n)
(Bos Taurus)
Mammalia IL1RN 34 35
  • 82.35 (n)
(Mus musculus)
Mammalia Il1rn 34 16 35
  • 81.17 (n)
(Rattus norvegicus)
Mammalia Il1rn 34
  • 78.53 (n)
(Ornithorhynchus anatinus)
Mammalia IL1RN 35
  • 58 (a)
(Monodelphis domestica)
Mammalia IL1RN 35
  • 54 (a)
(Gallus gallus)
Aves IL1B 34
  • 57.42 (n)
Species where no ortholog for IL1RN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1RN Gene

Gene Tree for IL1RN (if available)
Gene Tree for IL1RN (if available)

Paralogs for IL1RN Gene

Paralogs for IL1RN Gene

(2) SIMAP similar genes for IL1RN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL1RN: view

Variants for IL1RN Gene

Sequence variations from dbSNP and Humsavar for IL1RN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121913161 Pathogenic 113,131,068(+) CCATT(G/T)AGCCT reference, stop-gained
rs121913162 Pathogenic 113,129,619(+) ACAAC(C/T)AACTA reference, stop-gained
rs4252004 Likely benign 113,127,745(+) GGTAA(A/G)GCTAC intron-variant
rs4252023 Likely benign 113,132,796(+) GCTGA(C/T)CAGCC reference, synonymous-codon
rs4252027 Likely benign 113,133,181(+) CCTCT(C/T)GCCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IL1RN Gene

Variant ID Type Subtype PubMed ID
esv2720549 CNV deletion 23290073
esv995178 CNV deletion 20482838
nsv1072438 CNV deletion 25765185
nsv508102 OTHER sequence alteration 20534489

Variation tolerance for IL1RN Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RN Gene

Disorders for IL1RN Gene

MalaCards: The human disease database

(78) MalaCards diseases for IL1RN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
interleukin 1 receptor antagonist deficiency
  • osteomyelitis, sterile multifocal, with periostitis and pustulosis
microvascular complications of diabetes 4
  • diabetic nephropathy
gastric cancer risk after h. pylori infection
  • gastric cancer, somatic
atrophic gastritis
  • gastric atrophy
schnitzler syndrome
  • chronic urticaria with gammapathy
- elite association - COSMIC cancer census association via MalaCards
Search IL1RN in MalaCards View complete list of genes associated with diseases


  • Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. {ECO:0000269 PubMed:19494218}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269 PubMed:8786086}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for IL1RN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL1RN: view

No data available for Genatlas for IL1RN Gene

Publications for IL1RN Gene

  1. Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population. (PMID: 20188863) Taype C.A. … Shaw M.A. (Infect. Genet. Evol. 2010) 3 22 46 64
  2. Combined polymorphism analysis of glutathione S-transferase M1/G1 and interleukin-1B (IL-1B)/interleukin 1-receptor antagonist (IL-1RN) and gastric cancer risk in an Omani Arab Population. (PMID: 18779738) Al-Moundhri M.S. … Tanira M. (J. Clin. Gastroenterol. 2009) 3 22 46 64
  3. A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. The interleukin-1beta:interleukin-1 receptor antagonist balance in atherosclerosis. (PMID: 19574724) Olofsson P.S. … SirsjAP A. (Circ. J. 2009) 3 22 46 64
  4. Evaluation of the genetic background of standard-immunosuppressant-related toxicity in a cohort of 200 paediatric renal allograft recipients--a retrospective study. (PMID: 19644155) Grenda R. … KaliciA8ski P. (Ann. Transplant. 2009) 3 22 46 64
  5. An autoinflammatory disease with deficiency of the interleukin-1- receptor antagonist. (PMID: 19494218) Aksentijevich I. … Goldbach-Mansky R. (N. Engl. J. Med. 2009) 3 4 22 64

Products for IL1RN Gene

  • Addgene plasmids for IL1RN

Sources for IL1RN Gene

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