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IL1RL2 Gene

protein-coding   GIFtS: 60
GCID: GC02P102803

Interleukin 1 Receptor-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 1 Receptor-Like 21 2     IL1R-rp22 3
IL1RRP22 3 5     IL-36 Receptor2 3
Interleukin-1 Receptor-Related Protein 22 3     IL-1 Receptor-Related Protein 22
IL-1Rrp22 3     Interleukin-1 Receptor-Like 22
IL-36R2 3     

External Ids:    HGNC: 59991   Entrez Gene: 88082   Ensembl: ENSG000001155987   OMIM: 6045125   UniProtKB: Q9HB293   

Export aliases for IL1RL2 gene to outside databases

Previous GC identifers: GC02P100667 GC02P101256 GC02P102408 GC02P102424 GC02P102261 GC02P096567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL1RL2 Gene:
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient
gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1
beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1
receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and
interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
(provided by RefSeq, Jul 2008)

GeneCards Summary for IL1RL2 Gene:
IL1RL2 (interleukin 1 receptor-like 2) is a protein-coding gene. Diseases associated with IL1RL2 include temporal lobe epilepsy, and celiac disease. GO annotations related to this gene include interleukin-1, Type I, activating receptor activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAPL2.

UniProtKB/Swiss-Prot: ILRL2_HUMAN, Q9HB29
Function: Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B

Gene Wiki entry for IL1RL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1RL2 gene promoter:
         TBP   Gfi-1   GATA-1   RORalpha1   CREB   PPAR-gamma1   POU2F1   POU2F1a   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL1RL2 promoter sequence
   Search Chromatin IP Primers for IL1RL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1RL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12

IL1RL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1RL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102803:  view genomic region     (about GC identifiers)

Start:
102,803,433 bp from pter      End:
102,856,462 bp from pter
Size:
53,030 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ILRL2_HUMAN, Q9HB29 (See protein sequence)
Recommended Name: Interleukin-1 receptor-like 2 precursor  
Size: 575 amino acids; 65405 Da
Subunit: Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta
Sequence caution: Sequence=AAB53237.1; Type=Frameshift; Positions=556;
Secondary accessions: Q13525 Q45H74 Q53TU8 Q587I8

Explore the universe of human proteins at neXtProt for IL1RL2: NX_Q9HB29

Explore proteomics data for IL1RL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn41, Asn59, Asn109, Asn127, Asn184, Asn234, Asn250, Asn266, Asn299
  • Modification sites at PhosphoSitePlus

  • See IL1RL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003845.2  
    ENSEMBL proteins: 
     ENSP00000264257   ENSP00000387611   ENSP00000413348   ENSP00000442184  

    IL1RL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-1 receptor-like 2
    Immunoglobulin-like family of IL-1 receptors

    Selected InterPro protein domains (see all 7):
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold
     IPR015621 IL-1_rcpt_fam
     IPR007110 Ig-like_dom
     IPR004076 IL-1_rcpt_I-typ

    Graphical View of Domain Structure for InterPro Entry Q9HB29

    ProtoNet protein and cluster: Q9HB29

    3 Blocks protein domains:
    IPB000157 TIR domain
    IPB003599 Immunoglobulin subtype
    IPB004075 Interleukin-1 receptor type I family signature


    UniProtKB/Swiss-Prot: ILRL2_HUMAN, Q9HB29
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    IL1RL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILRL2_HUMAN, Q9HB29
    Function: Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B

         Genatlas biochemistry entry for IL1RL2:
    interleukin 1 receptor related protein 2,not binding IL1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004908interleukin-1 receptor activity TAS1833184
    GO:0004909interleukin-1, Type I, activating receptor activity IEA--
    GO:0005515protein binding ----
         
    IL1RL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL1RL2:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il1rl2):
     hematopoietic system  homeostasis/metabolism  immune system  integument  normal 

    IL1RL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL1RL2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1RL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1RL2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ILRL2_HUMAN, Q9HB29: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS1833184

    IL1RL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL1RL2 About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL1RL2
        IL-1 Family Signaling Pathways




        Pathway & Disease-focused RT2 Profiler PCR Array including IL1RL2: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL1RL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IL1RL2 (Q9HB293 ENSP000002642574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL18Q141163, ENSP000002803574I2D: score=1 STRING: ENSP00000280357
    IL1RNENSP000002592064STRING: ENSP00000259206
    IL1AENSP000002633394STRING: ENSP00000263339
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS8332913
    GO:0007165signal transduction TAS1833184
    GO:0019221cytokine-mediated signaling pathway TAS1833184
    GO:0032755positive regulation of interleukin-6 production IEA--
    GO:0045582positive regulation of T cell differentiation IEA--

    IL1RL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL1RL2 (ILRL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL1RL2 gene: 
    NM_003854.2  

    Unigene Cluster for IL1RL2:

    Interleukin 1 receptor-like 2
    Hs.659863  [show with all ESTs]
    Unigene Representative Sequence: AF284434
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264257(uc002tbs.3 uc002tbt.3) ENST00000481806 ENST00000421464
    ENST00000441515 ENST00000539491
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat IL1RL2

    Additional mRNA sequence: 

    AF284434.1 AK315334.1 BC107064.2 U49065.1 

    2 DOTS entries:

    DT.40120316  DT.86843818 

    8 AceView cDNA sequences:

    CA448166 NM_003854 U49065 AF284434 BG677958 AW991351 AW369406 AW747802 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                    
    SP2:                    -     -                                                         


    ECgene alternative splicing isoforms for IL1RL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL1RL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCCTCATT
    IL1RL2 Expression
    About this image


    IL1RL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Colon (Gastrointestinal Tract)
    IL1RL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL1RL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659863
        Pathway & Disease-focused RT2 Profiler PCR Array including IL1RL2: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL1RL2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1rl21 , 5 interleukin 1 receptor-like 21, 5 74.82(n)1
    67.2(a)1
      1 (18.96 cM)5
    1075271  NM_133193.31  NP_573456.11 
     403246275 
    chicken
    (Gallus gallus)
    Aves IL1R16
    --
    Uncharacterized protein
    40(a)
    31(a)
    many ↔ many
    many ↔ many
    1(133163682-133185156)
    1(133190561-133209036)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    38(a)
    1 → many
    GL343243.1(1720514-1747264)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7992791 interleukin-1 receptor-like 1-like 47.36(n)
    34.48(a)
      799279  XM_001339618.5  XP_001339654.4 


    ENSEMBL Gene Tree for IL1RL2 (if available)
    TreeFam Gene Tree for IL1RL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL1RL2 gene
    IL1RAPL22  IL1RAPL12  IL1RAP2  IL18RAP2  IL18R12  IL1R22  IL1RL12  IL1R12  
    1 SIMAP similar gene for IL1RL2 using alignment to 3 protein entries:     ILRL2_HUMAN (see all proteins):
    IL1R1

    IL1RL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL1RL2 (see all 1315)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs613393531,2
    C--96601154(+) TGTGT-/GTTTGCA 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs10300211,2
    C,F,A,H--102801478(-) TTTGCT/GGCTCT 1 -- us2k121Minor allele frequency- G:0.36NS EA NA CSA WA 2516
    rs1878062601,2
    --102801494(+) CAAAAC/TTTAAA 1 -- us2k10--------
    rs130034891,2
    C,F--102801502(+) AAAAGT/CCTGAC 1 -- us2k1 tfbs34Minor allele frequency- C:0.09NA WA 242
    rs1915437171,2
    --102801572(+) CTATGA/GAAAAA 1 -- us2k10--------
    rs347020501,2
    C,F--102801619(+) ACCCAA/GTGATT 1 -- us2k16Minor allele frequency- G:0.03NS NA WA CSA 218
    rs1442174621,2
    C--102801755(+) ATGAAC/TACATT 1 -- us2k10--------
    rs1995410181,2
    C--102801765(+) TTAAG-/TTTTTT 1 -- us2k10--------
    rs1453050121,2
    C--102801827(+) TTTAA-/TTGCTA 1 -- us2k10--------
    rs101818691,2
    C,F,H--102801852(+) GGAATC/AAGTTC 1 -- us2k117Minor allele frequency- A:0.37NS EA NA CSA WA 1340

    HapMap Linkage Disequilibrium report for IL1RL2 (102803433 - 102856462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IL1RL2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720460CNV Deletion23290073
    esv2564673CNV Deletion19546169
    esv2720462CNV Deletion23290073
    nsv874744CNV Loss21882294
    dgv4258n71CNV Loss21882294
    nsv874736CNV Loss21882294
    nsv874752CNV Loss21882294
    nsv874745CNV Loss21882294
    dgv4260n71CNV Loss21882294
    dgv4259n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): IL1RL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1RL2
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1RL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604512    OMIM disorders: --

    9 diseases for IL1RL2:    
    About MalaCards
    temporal lobe epilepsy    celiac disease    osteoarthritis    chronic lymphocytic leukemia
    inflammatory bowel disease    hepatitis b    parkinson's disease    hepatitis
    leukemia


    IL1RL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IL1RL2
    Human Genome Epidemiology (HuGE) Navigator: IL1RL2 (8 documents)

    Export disorders for IL1RL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL1RL2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with IL1RL2)
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    1. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2). (PubMed id 8898719)1, 2, 3, 9 Lovenberg T.W.... Maki R.A. (J. Neuroimmunol. 1996)
    2. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PubMed id 11466363)1, 2, 3, 9 Debets R....Kastelein R.A. (J. Immunol. 2001)
    3. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)1, 3, 9 Dale M. and Nicklin M.J. (Genomics 1999)
    4. Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis. (PubMed id 19684156)1, 4, 9 Solovieva S....Leino-Arjas P. (J. Rheumatol. 2009)
    5. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    6. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. (PubMed id 20353565)1, 4 NAokki A....Kujala U.M. (BMC Med. Genet. 2010)
    7. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    8. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    9. Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. (PubMed id 19180518)1, 4 Videman T....BattiAc M.C. (Arthritis Rheum. 2009)
    10. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8808 HGNC: 5999 AceView: IL1RL2 Ensembl:ENSG00000115598 euGenes: HUgn8808
    ECgene: IL1RL2 H-InvDB: IL1RL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL1RL2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il1rl2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL1RL2 gene:
    Search GeneIP for patents involving IL1RL2

    GeneCards and IP:
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