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Aliases for IL1RL2 Gene

Aliases for IL1RL2 Gene

  • Interleukin 1 Receptor Like 2 2 3 5
  • Interleukin-1 Receptor-Related Protein 2 3 4
  • IL-36 Receptor 3 4
  • IL-1Rrp2 3 4
  • IL1R-Rp2 3 4
  • IL1RRP2 3 4
  • IL-36R 3 4
  • IL-1 Receptor-Related Protein 2 3
  • Interleukin-1 Receptor-Like 2 3

External Ids for IL1RL2 Gene

Previous GeneCards Identifiers for IL1RL2 Gene

  • GC02P100667
  • GC02P101256
  • GC02P102408
  • GC02P102424
  • GC02P102803
  • GC02P096567

Summaries for IL1RL2 Gene

Entrez Gene Summary for IL1RL2 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RL2 Gene

IL1RL2 (Interleukin 1 Receptor Like 2) is a Protein Coding gene. Diseases associated with IL1RL2 include Psoriasis 14, Pustular. Among its related pathways are Immune System and Cytokine Signaling in Immune system. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type I, activating receptor activity. An important paralog of this gene is IL1R1.

UniProtKB/Swiss-Prot for IL1RL2 Gene

  • Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene Wiki entry for IL1RL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RL2 Gene

Genomics for IL1RL2 Gene

Regulatory Elements for IL1RL2 Gene

Enhancers for IL1RL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F102238 1.5 FANTOM5 Ensembl ENCODE 20.3 +54.1 54103 4.5 PKNOX1 ATF1 MLX WRNIP1 ARID4B DMAP1 ZNF48 SLC30A9 ZNF143 ZNF207 IL1RL2 IL1R2 LOC105373516 ENSG00000234389 IL18R1 IL1R1 IL18RAP GC02M102250
GH02F102226 1.1 FANTOM5 Ensembl ENCODE 17 +41.9 41944 3.8 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS IL1RL2 LOC105373516 IL1R2 IL1R1 IL18RAP GC02M102250
GH02F102158 1.5 FANTOM5 Ensembl ENCODE 16.7 -26.9 -26924 1.6 ZNF623 TEAD3 IL1RL2 LOC105373516 IL18RAP IL1R1 MAP4K4 PIR60869 GC02M102141
GH02F102032 1.2 FANTOM5 Ensembl ENCODE 12.1 -152.4 -152357 3.2 HDGF ATF1 MLX ZFP64 ARID4B ZNF48 FOS NFYC MXD4 MIER2 IL1R2 IL1R1 IL1RL2 LOC105373516 IL18RAP TBC1D8 MAP4K4 IL18R1
GH02F102215 0.2 Ensembl 11.8 +29.5 29544 0.2 IL1RL2 LOC105373516 GC02M102250
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IL1RL2 on UCSC Golden Path with GeneCards custom track

Promoters for IL1RL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000123364 1543 1001 SOX13 CTCF TCF7 MAX BCL6 MYC RAD21

Genomic Location for IL1RL2 Gene

Chromosome:
2
Start:
102,186,157 bp from pter
End:
102,240,002 bp from pter
Size:
53,846 bases
Orientation:
Plus strand

Genomic View for IL1RL2 Gene

Genes around IL1RL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RL2 Gene

Proteins for IL1RL2 Gene

  • Protein details for IL1RL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB29-ILRL2_HUMAN
    Recommended name:
    Interleukin-1 receptor-like 2
    Protein Accession:
    Q9HB29
    Secondary Accessions:
    • A4FU63
    • Q13525
    • Q45H74
    • Q53TU8
    • Q587I8

    Protein attributes for IL1RL2 Gene

    Size:
    575 amino acids
    Molecular mass:
    65405 Da
    Quaternary structure:
    • Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).
    SequenceCaution:
    • Sequence=AAB53237.1; Type=Frameshift; Positions=556; Evidence={ECO:0000305};

    Alternative splice isoforms for IL1RL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1RL2 Gene

Post-translational modifications for IL1RL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for IL1RL2 (IL-1 Rrp2/IL-1 R6)
  • Abcam antibodies for IL1RL2

No data available for DME Specific Peptides for IL1RL2 Gene

Domains & Families for IL1RL2 Gene

Suggested Antigen Peptide Sequences for IL1RL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB29

UniProtKB/Swiss-Prot:

ILRL2_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RL2: view

Function for IL1RL2 Gene

Molecular function for IL1RL2 Gene

GENATLAS Biochemistry:
interleukin 1 receptor related protein 2,not binding IL1
UniProtKB/Swiss-Prot Function:
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene Ontology (GO) - Molecular Function for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0004908 interleukin-1 receptor activity TAS 1833184
GO:0004909 interleukin-1, Type I, activating receptor activity IEA --
genes like me logo Genes that share ontologies with IL1RL2: view
genes like me logo Genes that share phenotypes with IL1RL2: view

Animal Models for IL1RL2 Gene

MGI Knock Outs for IL1RL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL1RL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RL2 Gene

Localization for IL1RL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1RL2 Gene COMPARTMENTS Subcellular localization image for IL1RL2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1833184
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IL1RL2: view

Pathways & Interactions for IL1RL2 Gene

genes like me logo Genes that share pathways with IL1RL2: view

Pathways by source for IL1RL2 Gene

1 R&D Systems pathway for IL1RL2 Gene

Interacting Proteins for IL1RL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264257%0d%0a9606.ENSP00000280357%0d%0a
Selected Interacting proteins: ENSP00000264257 Q9HB29-ILRL2_HUMAN for IL1RL2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006954 inflammatory response IEA --
GO:0006968 cellular defense response TAS 8332913
GO:0007165 signal transduction TAS 1833184
genes like me logo Genes that share ontologies with IL1RL2: view

No data available for SIGNOR curated interactions for IL1RL2 Gene

Transcripts for IL1RL2 Gene

mRNA/cDNA for IL1RL2 Gene

(17) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1RL2 Gene

Interleukin 1 receptor-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2: - -

Relevant External Links for IL1RL2 Gene

GeneLoc Exon Structure for
IL1RL2
ECgene alternative splicing isoforms for
IL1RL2

Expression for IL1RL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL1RL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RL2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.7), Skin - Not Sun Exposed (Suprapubic) (x6.5), and Esophagus - Mucosa (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1RL2 Gene



Protein tissue co-expression partners for IL1RL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL1RL2 Gene:

IL1RL2

SOURCE GeneReport for Unigene cluster for IL1RL2 Gene:

Hs.659863

mRNA Expression by UniProt/SwissProt for IL1RL2 Gene:

Q9HB29-ILRL2_HUMAN
Tissue specificity: Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
genes like me logo Genes that share expression patterns with IL1RL2: view

Primer Products

No data available for Protein differential expression in normal tissues for IL1RL2 Gene

Orthologs for IL1RL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1RL2 34 35
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia IL1RL2 34
  • 81.16 (n)
-- 35
  • 77 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia IL1RL2 34 35
  • 77.46 (n)
mouse
(Mus musculus)
Mammalia Il1rl2 34 16 35
  • 74.82 (n)
rat
(Rattus norvegicus)
Mammalia Il1rl2 34
  • 74.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RL2 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1RL2 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1R1 35
  • 40 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC799279 34
  • 47.36 (n)
CABZ01054962.1 35
  • 24 (a)
ManyToMany
CABZ01054965.1 35
  • 22 (a)
ManyToMany
Species where no ortholog for IL1RL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RL2 Gene

ENSEMBL:
Gene Tree for IL1RL2 (if available)
TreeFam:
Gene Tree for IL1RL2 (if available)

Paralogs for IL1RL2 Gene

Paralogs for IL1RL2 Gene

(1) SIMAP similar genes for IL1RL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL1RL2: view

Variants for IL1RL2 Gene

Sequence variations from dbSNP and Humsavar for IL1RL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164790 -- 102,201,402(+) tatcc(A/T)tctat intron-variant
rs10166535 -- 102,193,400(+) cagGA(G/T)tattt intron-variant
rs10167431 -- 102,236,342(+) TGTGG(C/T)CTTAG intron-variant, utr-variant-3-prime
rs10167608 -- 102,195,618(+) ctttc(C/T)ttctt intron-variant
rs10168021 -- 102,210,986(+) GGAGG(A/C)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RL2 Gene

Variant ID Type Subtype PubMed ID
esv2564673 CNV deletion 19546169
esv2720460 CNV deletion 23290073
esv2720462 CNV deletion 23290073
esv3559865 CNV deletion 23714750
esv3583991 CNV loss 25503493
nsv1138823 CNV deletion 24896259
nsv582555 CNV gain 21841781
nsv582556 CNV loss 21841781

Variation tolerance for IL1RL2 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RL2 Gene

Human Gene Mutation Database (HGMD)
IL1RL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1RL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL2 Gene

Disorders for IL1RL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL1RL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
psoriasis 14, pustular
  • pustulosis of palm and sole
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL1RL2

Genetic Association Database (GAD)
IL1RL2
Human Genome Epidemiology (HuGE) Navigator
IL1RL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1RL2
genes like me logo Genes that share disorders with IL1RL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RL2 Gene

Publications for IL1RL2 Gene

  1. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PMID: 11466363) Debets R. … Kastelein R.A. (J. Immunol. 2001) 2 3 4 22 64
  2. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2). (PMID: 8898719) Lovenberg T.W. … Maki R.A. (J. Neuroimmunol. 1996) 2 3 4 22 64
  3. Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis. (PMID: 19684156) Solovieva S. … Leino-Arjas P. (J. Rheumatol. 2009) 3 22 46 64
  4. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 22 64
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 46 64

Products for IL1RL2 Gene

Sources for IL1RL2 Gene

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