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Aliases for IL1RL1 Gene

Aliases for IL1RL1 Gene

  • Interleukin 1 Receptor Like 1 2 3
  • Homolog Of Mouse Growth Stimulation-Expressed 2 3
  • Interleukin 1 Receptor-Like 1 3 5
  • DER4 3 4
  • ST2 3 4
  • T1 3 4
  • Interleukin 1 Receptor-Related Protein 3
  • Growth Stimulation-Expressed 3
  • Protein ST2 4
  • FIT-1 3
  • IL33R 3
  • ST2L 3
  • ST2V 3

External Ids for IL1RL1 Gene

Previous GeneCards Identifiers for IL1RL1 Gene

  • GC02P100792
  • GC02P101380
  • GC02P102532
  • GC02P102549
  • GC02P102386
  • GC02P102927
  • GC02P096692

Summaries for IL1RL1 Gene

Entrez Gene Summary for IL1RL1 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RL1 Gene

IL1RL1 (Interleukin 1 Receptor Like 1) is a Protein Coding gene. Diseases associated with IL1RL1 include yellow fever. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor signaling protein activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL1RL1 Gene

  • Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

  • Isoform B: Inhibits IL-33 signaling.

Gene Wiki entry for IL1RL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RL1 Gene

Genomics for IL1RL1 Gene

Regulatory Elements for IL1RL1 Gene

Promoters for IL1RL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL1RL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL1RL1 Gene

Chromosome:
2
Start:
102,311,502 bp from pter
End:
102,352,366 bp from pter
Size:
40,865 bases
Orientation:
Plus strand

Genomic View for IL1RL1 Gene

Genes around IL1RL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RL1 Gene

Proteins for IL1RL1 Gene

  • Protein details for IL1RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01638-ILRL1_HUMAN
    Recommended name:
    Interleukin-1 receptor-like 1
    Protein Accession:
    Q01638
    Secondary Accessions:
    • A8K6B3
    • B4E0I3
    • Q53TU7
    • Q8NEJ3
    • Q9ULV7
    • Q9UQ44

    Protein attributes for IL1RL1 Gene

    Size:
    556 amino acids
    Molecular mass:
    63358 Da
    Quaternary structure:
    • Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoechiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.

    Three dimensional structures from OCA and Proteopedia for IL1RL1 Gene

    Alternative splice isoforms for IL1RL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1RL1 Gene

Proteomics data for IL1RL1 Gene at MOPED

Post-translational modifications for IL1RL1 Gene

  • Glycosylation at Asn 54, Asn 95, Asn 101, Asn 140, Asn 191, Asn 232, Asn 254, and Asn 273
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1RL1 Gene

Antibody Products

Protein Products

  • Enzo Life Sciences proteins for IL1RL1

No data available for DME Specific Peptides for IL1RL1 Gene

Domains & Families for IL1RL1 Gene

Suggested Antigen Peptide Sequences for IL1RL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01638

UniProtKB/Swiss-Prot:

ILRL1_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RL1: view

Function for IL1RL1 Gene

Molecular function for IL1RL1 Gene

GENATLAS Biochemistry:
interleukin 1receptor-like 1
UniProtKB/Swiss-Prot Function:
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
UniProtKB/Swiss-Prot Function:
Isoform B: Inhibits IL-33 signaling.

Gene Ontology (GO) - Molecular Function for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002113 interleukin-33 binding IEA --
genes like me logo Genes that share ontologies with IL1RL1: view
genes like me logo Genes that share phenotypes with IL1RL1: view

Animal Models for IL1RL1 Gene

MGI Knock Outs for IL1RL1:

Animal Model Products

CRISPR Products

miRNA for IL1RL1 Gene

miRTarBase miRNAs that target IL1RL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RL1 Gene

Localization for IL1RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RL1 Gene

Isoform C: Cell membrane.
Isoform B: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1RL1 Gene COMPARTMENTS Subcellular localization image for IL1RL1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with IL1RL1: view

Pathways & Interactions for IL1RL1 Gene

genes like me logo Genes that share pathways with IL1RL1: view

Pathways by source for IL1RL1 Gene

Gene Ontology (GO) - Biological Process for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 10527832
GO:0007165 signal transduction TAS 1482686
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0032754 positive regulation of interleukin-5 production IEA --
GO:0035556 intracellular signal transduction TAS --
genes like me logo Genes that share ontologies with IL1RL1: view

No data available for SIGNOR curated interactions for IL1RL1 Gene

Drugs & Compounds for IL1RL1 Gene

No Compound Related Data Available

Transcripts for IL1RL1 Gene

Unigene Clusters for IL1RL1 Gene

Interleukin 1 receptor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1: - - - - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for IL1RL1 Gene

GeneLoc Exon Structure for
IL1RL1
ECgene alternative splicing isoforms for
IL1RL1

Expression for IL1RL1 Gene

mRNA expression in normal human tissues for IL1RL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RL1 Gene

This gene is overexpressed in Lung (x13.8) and Kidney - Cortex (x8.5).

Protein differential expression in normal tissues from HIPED for IL1RL1 Gene

This gene is overexpressed in Breast (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1RL1 Gene



SOURCE GeneReport for Unigene cluster for IL1RL1 Gene Hs.66

mRNA Expression by UniProt/SwissProt for IL1RL1 Gene

Q01638-ILRL1_HUMAN
Tissue specificity: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
genes like me logo Genes that share expression patterns with IL1RL1: view

Protein tissue co-expression partners for IL1RL1 Gene

Primer Products

In Situ Assay Products

Orthologs for IL1RL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL1RL1 35
  • 77.8 (n)
  • 67.87 (a)
IL1RL1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1RL1 35
  • 80.64 (n)
  • 72.48 (a)
IL1RL1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1rl1 35
  • 75.23 (n)
  • 67.27 (a)
Il1rl1 16
Il1rl1 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC749266 35
  • 99.28 (n)
  • 98.37 (a)
rat
(Rattus norvegicus)
Mammalia Il1rl1 35
  • 74.09 (n)
  • 64.49 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1RL1 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RL1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1RL1 35
  • 55.51 (n)
  • 43.47 (a)
IL1RL1 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL1RL1 36
  • 37 (a)
OneToOne
Species with no ortholog for IL1RL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1RL1 Gene

ENSEMBL:
Gene Tree for IL1RL1 (if available)
TreeFam:
Gene Tree for IL1RL1 (if available)

Paralogs for IL1RL1 Gene

Paralogs for IL1RL1 Gene

(2) SIMAP similar genes for IL1RL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IL1RL1: view

Variants for IL1RL1 Gene

Sequence variations from dbSNP and Humsavar for IL1RL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1041973 - 102,339,008(+) AGCTG(A/C)AGTTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs4988956 - 102,351,547(+) TCACT(A/G)CAGTG reference, missense
rs10192036 - 102,351,751(+) CCCTC(A/C)AGCAT reference, missense
rs10204137 - 102,351,752(+) CCTCC(A/G)GCATC reference, missense
rs10192157 - 102,351,896(+) TTTGA(C/T)TCCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IL1RL1 Gene

Variant ID Type Subtype PubMed ID
esv1258097 CNV Deletion 17803354
esv2673990 CNV Deletion 23128226
nsv820800 CNV Duplication 20802225
nsv829585 CNV Loss 20364138
esv2585327 CNV Deletion 19546169

Variation tolerance for IL1RL1 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.34; 99.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RL1 Gene

HapMap Linkage Disequilibrium report
IL1RL1
Human Gene Mutation Database (HGMD)
IL1RL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL1 Gene

Disorders for IL1RL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL1RL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
yellow fever
  • jungle yellow fever
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL1RL1

Genetic Association Database (GAD)
IL1RL1
Human Genome Epidemiology (HuGE) Navigator
IL1RL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1RL1
genes like me logo Genes that share disorders with IL1RL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RL1 Gene

Publications for IL1RL1 Gene

  1. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. (PMID: 16286016) Schmitz J. … Kastelein R.A. (Immunity 2005) 2 3 4 67
  2. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 23
  3. Levels of soluble ST2 in serum associated with severity of dengue due to tumour necrosis factor alpha stimulation. (PMID: 19889931) Houghton-Trivino N. … Castellanos J.E. (J. Gen. Virol. 2010) 3 23
  4. Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. (PMID: 20385815) Pastorelli L. … Pizarro T.T. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells. (PMID: 19756962) Aoki S. … Yanagisawa K. (Mol. Cell. Biochem. 2010) 3 23

Products for IL1RL1 Gene

Sources for IL1RL1 Gene

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