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Aliases for IL1RL1 Gene

Aliases for IL1RL1 Gene

  • Interleukin 1 Receptor-Like 1 2 3
  • Homolog Of Mouse Growth Stimulation-Expressed 2 3
  • DER4 3 4
  • ST2 3 4
  • T1 3 4
  • Interleukin 1 Receptor-Related Protein 3
  • Interleukin-1 Receptor-Like 1 3
  • Growth Stimulation-Expressed 3
  • Protein ST2 4
  • FIT-1 3
  • IL33R 3
  • ST2L 3
  • ST2V 3

External Ids for IL1RL1 Gene

Previous GeneCards Identifiers for IL1RL1 Gene

  • GC02P100792
  • GC02P101380
  • GC02P102532
  • GC02P102549
  • GC02P102386
  • GC02P102927
  • GC02P096692

Summaries for IL1RL1 Gene

Entrez Gene Summary for IL1RL1 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RL1 Gene

IL1RL1 (Interleukin 1 Receptor-Like 1) is a Protein Coding gene. Diseases associated with IL1RL1 include yellow fever and allergic conjunctivitis. Among its related pathways are NOD-like Receptor Signaling Pathways and TRAF Pathway. GO annotations related to this gene include receptor signaling protein activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL1RL1 Gene

  • Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

Gene Wiki entry for IL1RL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RL1 Gene

Genomics for IL1RL1 Gene

Regulatory Elements for IL1RL1 Gene

Genomic Location for IL1RL1 Gene

102,311,502 bp from pter
102,352,332 bp from pter
40,831 bases
Plus strand

Genomic View for IL1RL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RL1 Gene

Proteins for IL1RL1 Gene

  • Protein details for IL1RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-1 receptor-like 1
    Protein Accession:
    Secondary Accessions:
    • A8K6B3
    • B4E0I3
    • Q53TU7
    • Q8NEJ3
    • Q9ULV7
    • Q9UQ44

    Protein attributes for IL1RL1 Gene

    556 amino acids
    Molecular mass:
    63358 Da
    Quaternary structure:
    • Interacts with MYD88, IRAK1, IRAK4, and TRAF6.

    Three dimensional structures from OCA and Proteopedia for IL1RL1 Gene

    Alternative splice isoforms for IL1RL1 Gene


neXtProt entry for IL1RL1 Gene

Proteomics data for IL1RL1 Gene at MOPED

Post-translational modifications for IL1RL1 Gene

  • Glycosylation at Asn54, Asn95, Asn101, Asn140, Asn191, Asn232, Asn254, and Asn273
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1RL1 Gene

No data available for DME Specific Peptides for IL1RL1 Gene

Domains for IL1RL1 Gene

Gene Families for IL1RL1 Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for IL1RL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q01638
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RL1: view

Function for IL1RL1 Gene

Molecular function for IL1RL1 Gene

GENATLAS Biochemistry: interleukin 1receptor-like 1
UniProtKB/Swiss-Prot Function: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

Gene Ontology (GO) - Molecular Function for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002113 interleukin-33 binding IEA --
GO:0002114 interleukin-33 receptor activity IEA --
GO:0004896 cytokine receptor activity TAS 10191101
GO:0004908 interleukin-1 receptor activity IEA --
GO:0005057 receptor signaling protein activity TAS 1482686
genes like me logo Genes that share ontologies with IL1RL1: view
genes like me logo Genes that share phenotypes with IL1RL1: view

Animal Models for IL1RL1 Gene

MGI Knock Outs for IL1RL1:

miRNA for IL1RL1 Gene

miRTarBase miRNAs that target IL1RL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL1RL1 Gene

Localization for IL1RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RL1 Gene

Isoform C: Cell membrane.
Isoform B: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL1RL1 Gene COMPARTMENTS Subcellular localization image for IL1RL1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with IL1RL1: view

Pathways for IL1RL1 Gene

genes like me logo Genes that share pathways with IL1RL1: view

Pathways by source for IL1RL1 Gene

1 Qiagen pathway for IL1RL1 Gene
1 R&D Systems pathway for IL1RL1 Gene

Gene Ontology (GO) - Biological Process for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002826 negative regulation of T-helper 1 type immune response IEA --
GO:0006955 immune response NAS 10527832
GO:0007165 signal transduction TAS 1482686
GO:0019221 cytokine-mediated signaling pathway --
GO:0032689 negative regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IL1RL1: view

Transcripts for IL1RL1 Gene

Unigene Clusters for IL1RL1 Gene

Interleukin 1 receptor-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1: - - - - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for IL1RL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL1RL1 Gene

mRNA expression in normal human tissues for IL1RL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RL1 Gene

This gene is overexpressed in Lung (13.8) and Kidney - Cortex (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL1RL1 Gene

SOURCE GeneReport for Unigene cluster for IL1RL1 Gene Hs.66

mRNA Expression by UniProt/SwissProt for IL1RL1 Gene

Tissue specificity: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.
genes like me logo Genes that share expressions with IL1RL1: view

Orthologs for IL1RL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC749266 35
  • 99.28 (n)
  • 98.37 (a)
(Bos Taurus)
Mammalia IL1RL1 35
  • 77.8 (n)
  • 67.87 (a)
IL1RL1 36
  • 67 (a)
(Canis familiaris)
Mammalia IL1RL1 35
  • 80.64 (n)
  • 72.48 (a)
IL1RL1 36
  • 71 (a)
(Mus musculus)
Mammalia Il1rl1 35
  • 75.23 (n)
  • 67.27 (a)
Il1rl1 16
Il1rl1 36
  • 66 (a)
(Monodelphis domestica)
Mammalia IL1RL1 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia IL1RL1 36
  • 45 (a)
(Rattus norvegicus)
Mammalia Il1rl1 35
  • 74.09 (n)
  • 64.49 (a)
(Gallus gallus)
Aves IL1RL1 35
  • 55.51 (n)
  • 43.47 (a)
IL1RL1 36
  • 31 (a)
(Anolis carolinensis)
Reptilia IL1RL1 36
  • 37 (a)
Species with no ortholog for IL1RL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1RL1 Gene

Gene Tree for IL1RL1 (if available)
Gene Tree for IL1RL1 (if available)

Paralogs for IL1RL1 Gene

Paralogs for IL1RL1 Gene

Selected SIMAP similar genes for IL1RL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IL1RL1: view

Variants for IL1RL1 Gene

Sequence variations from dbSNP and Humsavar for IL1RL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12905 -- 102,343,547(+) TCTTC(A/G)GGATG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs873022 -- 102,339,223(+) GTTGA(G/T)GTCTA intron-variant
rs950880 -- 102,316,102(-) ATAAG(G/T)GTGGA intron-variant
rs950881 -- 102,316,052(-) CCCAG(A/C)GACCA intron-variant
rs953934 -- 102,315,833(-) CAAAA(A/G)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RL1 Gene

Variant ID Type Subtype PubMed ID
esv1258097 CNV Deletion 17803354
esv2673990 CNV Deletion 23128226
nsv820800 CNV Duplication 20802225
nsv829585 CNV Loss 20364138
esv2585327 CNV Deletion 19546169

Relevant External Links for IL1RL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL1 Gene

Disorders for IL1RL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IL1RL1 Gene including...

Search for IL1RL1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for IL1RL1 Gene

(6) Novoseek inferred disease relationships for IL1RL1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 39.8 9
asthma 28.1 9
dermatitis atopic 27.3 1
glioblastoma 17.8 3
tumors 3.42 1

Relevant External Links for IL1RL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL1RL1: view

No data available for UniProtKB/Swiss-Prot for IL1RL1 Gene

Publications for IL1RL1 Gene

  1. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 23
  2. Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM. (PMID: 10527832) Tominaga S. … Komatsu N. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. The cloning and nucleotide sequence of human ST2L cDNA. (PMID: 10936050) Li H. … Yanagisawa K. (Genomics 2000) 3 4 23
  4. Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. (PMID: 11478810) Tago K. … Tominaga S. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  5. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. (PMID: 19671251) Castano R. … Desrosiers M. (Am J Rhinol Allergy 2009) 3 23 48

Products for IL1RL1 Gene

Sources for IL1RL1 Gene

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