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Aliases for IL1RL1 Gene

Aliases for IL1RL1 Gene

  • Interleukin 1 Receptor Like 1 2 3 5
  • Homolog Of Mouse Growth Stimulation-Expressed 2 3
  • DER4 3 4
  • ST2 3 4
  • T1 3 4
  • Interleukin 1 Receptor-Related Protein 3
  • Interleukin-1 Receptor-Like 1 3
  • Growth Stimulation-Expressed 3
  • Protein ST2 4
  • FIT-1 3
  • IL33R 3
  • ST2L 3
  • ST2V 3

External Ids for IL1RL1 Gene

Previous GeneCards Identifiers for IL1RL1 Gene

  • GC02P100792
  • GC02P101380
  • GC02P102532
  • GC02P102549
  • GC02P102386
  • GC02P102927
  • GC02P096692

Summaries for IL1RL1 Gene

Entrez Gene Summary for IL1RL1 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RL1 Gene

IL1RL1 (Interleukin 1 Receptor Like 1) is a Protein Coding gene. Among its related pathways are Th2 Differentiation Pathway and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include signal transducer activity, downstream of receptor and interleukin-1 receptor activity. An important paralog of this gene is IL1R1.

UniProtKB/Swiss-Prot for IL1RL1 Gene

  • Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

  • Isoform B: Inhibits IL-33 signaling.

Gene Wiki entry for IL1RL1 Gene

Additional gene information for IL1RL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RL1 Gene

Genomics for IL1RL1 Gene

Regulatory Elements for IL1RL1 Gene

Enhancers for IL1RL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H102335 1.6 FANTOM5 Ensembl ENCODE 56.3 +25.3 25278 2 PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 NCOA1 IL1RL1 IL18R1 IL18RAP ENSG00000234389 SDR42E1P5
GH02H102305 0.9 FANTOM5 ENCODE 58.2 -5.9 -5905 1 GTF2E2 E2F5 MAFG IL1RL1 ENSG00000234389 IL18R1 GC02M102241
GH02H102301 1.1 FANTOM5 ENCODE 38.3 -9.4 -9367 0 HDAC1 CTCF PKNOX1 BATF RAD21 ZNF766 GATA3 GATA2 EED SMC3 IL1RL1 IL18RAP IL1RL2 GC02M102241
GH02H102306 0.5 FANTOM5 78.4 -7.0 -7025 0 JUN HLF IL1RL1 IL18R1 GC02M102241
GH02H102271 0.5 FANTOM5 61.7 -39.6 -39561 0 CTCF IL1RL1 IL18RAP IL18R1 GC02M102241
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL1RL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL1RL1 Gene

Chromosome:
2
Start:
102,311,502 bp from pter
End:
102,352,366 bp from pter
Size:
40,865 bases
Orientation:
Plus strand

Genomic View for IL1RL1 Gene

Genes around IL1RL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RL1 Gene

Proteins for IL1RL1 Gene

  • Protein details for IL1RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01638-ILRL1_HUMAN
    Recommended name:
    Interleukin-1 receptor-like 1
    Protein Accession:
    Q01638
    Secondary Accessions:
    • A8K6B3
    • B4E0I3
    • Q53TU7
    • Q8NEJ3
    • Q9ULV7
    • Q9UQ44

    Protein attributes for IL1RL1 Gene

    Size:
    556 amino acids
    Molecular mass:
    63358 Da
    Quaternary structure:
    • Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.

    Three dimensional structures from OCA and Proteopedia for IL1RL1 Gene

    Alternative splice isoforms for IL1RL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1RL1 Gene

Post-translational modifications for IL1RL1 Gene

  • Glycosylation at posLast=5454, posLast=9595, posLast=101101, isoforms=4, 2, 3140, isoforms=4, 2, 3191, posLast=232232, posLast=254254, and isoforms=4, 2273
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for IL1RL1

Assay Products

  • Cloud-Clone Corp. Assay Kits for IL1RL1

No data available for DME Specific Peptides for IL1RL1 Gene

Domains & Families for IL1RL1 Gene

Gene Families for IL1RL1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IL1RL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01638

UniProtKB/Swiss-Prot:

ILRL1_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RL1: view

Function for IL1RL1 Gene

Molecular function for IL1RL1 Gene

GENATLAS Biochemistry:
interleukin 1receptor-like 1
UniProtKB/Swiss-Prot Function:
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
UniProtKB/Swiss-Prot Function:
Isoform B: Inhibits IL-33 signaling.

Phenotypes From GWAS Catalog for IL1RL1 Gene

Gene Ontology (GO) - Molecular Function for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002113 interleukin-33 binding IEA --
GO:0002114 interleukin-33 receptor activity IEA --
GO:0004896 cytokine receptor activity TAS 10191101
GO:0004908 interleukin-1 receptor activity IEA --
GO:0005057 signal transducer activity, downstream of receptor TAS 1482686
genes like me logo Genes that share ontologies with IL1RL1: view
genes like me logo Genes that share phenotypes with IL1RL1: view

Animal Models for IL1RL1 Gene

MGI Knock Outs for IL1RL1:

Animal Model Products

CRISPR Products

miRNA for IL1RL1 Gene

miRTarBase miRNAs that target IL1RL1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL1RL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RL1 Gene

Localization for IL1RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RL1 Gene

Isoform C: Cell membrane.
Isoform B: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1RL1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IL1RL1: view

Pathways & Interactions for IL1RL1 Gene

genes like me logo Genes that share pathways with IL1RL1: view

Pathways by source for IL1RL1 Gene

Gene Ontology (GO) - Biological Process for IL1RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002826 negative regulation of T-helper 1 type immune response IEA --
GO:0006955 immune response NAS 10527832
GO:0007165 signal transduction TAS 1482686
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0032689 negative regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IL1RL1: view

No data available for SIGNOR curated interactions for IL1RL1 Gene

Drugs & Compounds for IL1RL1 Gene

No Compound Related Data Available

Transcripts for IL1RL1 Gene

Unigene Clusters for IL1RL1 Gene

Interleukin 1 receptor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL1RL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1: - - - - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for IL1RL1 Gene

GeneLoc Exon Structure for
IL1RL1
ECgene alternative splicing isoforms for
IL1RL1

Expression for IL1RL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL1RL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RL1 Gene

This gene is overexpressed in Lung (x13.8) and Kidney - Cortex (x8.5).

Protein differential expression in normal tissues from HIPED for IL1RL1 Gene

This gene is overexpressed in Breast (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1RL1 Gene



Protein tissue co-expression partners for IL1RL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL1RL1 Gene:

IL1RL1

SOURCE GeneReport for Unigene cluster for IL1RL1 Gene:

Hs.66

mRNA Expression by UniProt/SwissProt for IL1RL1 Gene:

Q01638-ILRL1_HUMAN
Tissue specificity: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.

Evidence on tissue expression from TISSUES for IL1RL1 Gene

  • Blood(4.4)
  • Bone marrow(4.2)
  • Lung(2.8)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with IL1RL1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RL1 Gene

Orthologs for IL1RL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC749266 33
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia IL1RL1 33 34
  • 80.64 (n)
cow
(Bos Taurus)
Mammalia IL1RL1 33 34
  • 77.8 (n)
mouse
(Mus musculus)
Mammalia Il1rl1 33 16 34
  • 75.23 (n)
rat
(Rattus norvegicus)
Mammalia Il1rl1 33
  • 74.09 (n)
oppossum
(Monodelphis domestica)
Mammalia IL1RL1 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RL1 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1RL1 33 34
  • 55.51 (n)
lizard
(Anolis carolinensis)
Reptilia IL1RL1 34
  • 37 (a)
OneToOne
Species where no ortholog for IL1RL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1RL1 Gene

ENSEMBL:
Gene Tree for IL1RL1 (if available)
TreeFam:
Gene Tree for IL1RL1 (if available)

Paralogs for IL1RL1 Gene

Paralogs for IL1RL1 Gene

(2) SIMAP similar genes for IL1RL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IL1RL1: view

Variants for IL1RL1 Gene

Sequence variations from dbSNP and Humsavar for IL1RL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000045629 -- 102,313,975(+) GCTAG(C/T)TAGGC intron-variant
rs1000297701 -- 102,327,893(+) AGGAC(C/T)AGATG intron-variant
rs1000307004 -- 102,340,989(+) AGGTT(C/T)TCTGA intron-variant
rs1000503299 -- 102,351,104(+) TTGAG(C/G)GGCAA intron-variant
rs1000649731 -- 102,312,923(+) AATCG(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RL1 Gene

Variant ID Type Subtype PubMed ID
esv1258097 CNV deletion 17803354
esv2585327 CNV deletion 19546169
esv2673990 CNV deletion 23128226
esv3591787 CNV loss 21293372
esv3591788 CNV gain 21293372
esv3591789 CNV loss 21293372
nsv1160830 CNV deletion 26073780
nsv820800 CNV duplication 20802225
nsv829585 CNV loss 20364138

Variation tolerance for IL1RL1 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.34; 99.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RL1 Gene

Human Gene Mutation Database (HGMD)
IL1RL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1RL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL1 Gene

Disorders for IL1RL1 Gene

Relevant External Links for IL1RL1

Genetic Association Database (GAD)
IL1RL1
Human Genome Epidemiology (HuGE) Navigator
IL1RL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1RL1

No disorders were found for IL1RL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL1RL1 Gene

Publications for IL1RL1 Gene

  1. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. (PMID: 19671251) Castano R … Desrosiers M (American journal of rhinology & allergy 2009) 3 22 45 60
  2. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. (PMID: 16286016) Schmitz J … Kastelein RA (Immunity 2005) 2 3 4 60
  3. Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. (PMID: 11478810) Tago K … Tominaga S (Biochemical and biophysical research communications 2001) 3 4 22 60
  4. The cloning and nucleotide sequence of human ST2L cDNA. (PMID: 10936050) Li H … Yanagisawa K (Genomics 2000) 3 4 22 60
  5. Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM. (PMID: 10527832) Tominaga Si … Komatsu N (Biochemical and biophysical research communications 1999) 3 4 22 60

Products for IL1RL1 Gene

Sources for IL1RL1 Gene

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