IL1RL1 Gene

Aliases
for IL1RL1 gene

Previous GC identifers: GC02P100792 GC02P101380 GC02P102532 GC02P102549 GC02P102386 GC02P102294 GC02P096692

Summaries
for IL1RL1 gene

Genomic Views
for IL1RL1 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_022171.15  

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1RL1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1RL1

IL1RL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102927:  view genomic region     (about GC identifiers)

Proteins
for IL1RL1 gene

Explore the universe of human proteins at neXtProt for IL1RL1: NX_Q01638

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL1RL1 (ST2/IL-1 R4)
	Enzo Life Sciences proteins for IL1RL1
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IL1RL1 OriGene Custom Protein Services for IL1RL1
	GenScript Custom Purified and Recombinant Proteins Services for IL1RL1
	Sino Biological Recombinant Protein for IL1RL1
	ProSpec Recombinant Protein for IL1RL1
	Uscn Proteins for IL1RL1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL1RL1
	R&D Systems Antibodies for IL1RL1 (ST2/IL-1 R4)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IL1RL1
	GenScript Custom Superior Antibodies Services for IL1RL1
	Novus Biologicals IL1RL1 Antibodies
	Search for Antibodies for IL1RL1 at Abcam
	Uscn Antibodies for IL1RL1
	ThermoFisher Antibodies for IL1RL1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL1RL1 (ST2/IL-1 R4)         (see all)
	GenScript Custom Assay Services for IL1RL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL1RL1

Protein Domains /
Families
for IL1RL1 gene

ProtoNet protein and cluster: Q01638

Function
for IL1RL1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IL1RL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1RL1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate IL1RL1:
		hsa-miR-3065-5p
		SwitchGear 3'UTR luciferase reporter plasmid: IL1RL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL1RL1 (see all 7) OriGene shRNA RFP: IL1RL1 OriGene siRNA: IL1RL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1RL1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IL1RL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL1RL1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL1RL1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IL1RL1 (NM_016232)
		Sino Biological Human cDNA Clone for IL1RL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1RL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1RL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL1RL1
		Search LifeMap BioReagents cell lines for IL1RL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RL1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 3 alleles) (MGI details for Il1rl1)

Pathways & Interactions
for IL1RL1 gene

	Super-pathway	contained gene-specific pathways
1	TRAF Pathway	Toll-Like Receptors Pathway 0.41

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for IL1RL1

Toll-Like Receptors Pathway

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

Drugs & Compounds
for IL1RL1 gene

Transcripts
for IL1RL1 gene

Expression
for IL1RL1 gene

IL1RL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LungRespiratory BronchiolesBasal Cells			Lung
	Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem Cells			Blood
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	Human umbilical vein endothelial cells (HUVEC) (Primary Cell)			Endothelium
	Fetal cardiomyocytes (20 weeks) (Primary Cell)			Heart, Myocardium
	Alveolar type II cells (Derivation of mature...)			Lung

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL1RL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL1RL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1RL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1RL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RL1

Orthologs
for IL1RL1 gene

Paralogs
for IL1RL1 gene

Paralogs for IL1RL1 gene

IL1RAPL2²  IL1RL2²  IL1RAP²  IL1RAPL1²  IL18RAP²  IL18R1²  SIGIRR²  IL1R2²  

IL1R1²  

3 SIMAP similar genes for IL1RL1 using alignment to 6 protein entries:     ILRL1_HUMAN (see all proteins):

IL1R1    IL18R1    IL1RAPL2

IL1RL1 for paralogs           About GeneDecksing

Genomic Variants
for IL1RL1 gene

10/955 NCBI SNPs in IL1RL1 are shown (see all 955)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs65431141,2	C,A,	--	102925994(+)	AAAAAC/ACCAAA	1	--	us2k1 trp3		3		WA NA	6
rs794955101,2	C,	--	102926212(+)	AATAAA/GTGATT	1	--	us2k1		0	--	--	--	--
rs1894268171,2		--	102926236(+)	AGTCAC/TAGTCC	1	--	us2k1		0	--	--	--	--
rs621517011,2	C,F,	--	102926261(+)	TAGTAC/TGCAAA	1	--	us2k1		6		NA CSA WA	246
rs1820263591,2		--	102926262(+)	AGTACA/GCAAAT	1	--	us2k1		0	--	--	--	--
rs1167239631,2	F,	--	102926287(+)	CTCCTC/TGATGT	1	--	us2k1		1		WA	118
rs1852241571,2		--	102926302(+)	TTTCAC/TCTTTT	1	--	us2k1		0	--	--	--	--
rs67213461,2	C,A,H,	--	102926320(+)	GTGACC/TCTAGG	1	--	us2k1		9		NA WA EA	370
rs124708641,2	C,F,A,H,	--	102926362(+)	GGGACG/AAGCGT	1	--	us2k1		9		NA WA EA	370
rs124708671,2	C,F,H,	--	102926366(+)	CGAGCG/ATCTTG	1	--	us2k1		6		NA WA EA	364

HapMap Linkage Disequilibrium report for IL1RL1 (102927962 - 102968497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IL1RL1
     1 CNV: 97927
     1 Indel: 26396

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL1RL1

DNA2.0 Custom Variant and Variant Library Synthesis for IL1RL1

Disorders / Diseases
for IL1RL1 gene

20/35 diseases for IL1RL1

6 Novoseek disease relationships for IL1RL1 gene    About this table

Publications
for IL1RL1 gene

PubMed articles for IL1RL1 gene, integrated from 9 sources (see all 137): (articles sorted by number of sources associating them with IL1RL1)

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1. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. (PubMed id 16286016)^{1, 2, 3} Schmitz J....Kastelein R.A. (2005)
2. Nucleotide sequence of a complementary DNA for human ST2. (PubMed id 1482686)^{1, 2, 3} Tominaga S....Tetsuka T. (1992)
3. Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. (PubMed id 11478810)^{1, 2, 9} Tago K....Tominaga S. (2001)
4. Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM. (PubMed id 10527832)^{1, 2, 9} Tominaga S....Komatsu N. (1999)
5. The cloning and nucleotide sequence of human ST2L cDNA. (PubMed id 10936050)^{1, 2, 9} Li H....Yanagisawa K. (2000)
6. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)^{1, 3, 9} Dale M. and Nicklin M.J. (1999)
7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
8. An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
10. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)

External Searches for IL1RL1 gene

Genome Databases showing IL1RL1 gene

Other Databases showing IL1RL1 gene

Specialized Databases showing IL1RL1 gene

Products
for IL1RL1 gene