Aliases for IL1RL1 Gene
External Ids for IL1RL1 Gene
Previous GeneCards Identifiers for IL1RL1 Gene
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1RL1 Gene
IL1RL1 (Interleukin 1 Receptor Like 1) is a Protein Coding gene. Diseases associated with IL1RL1 include yellow fever. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor signaling protein activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAP.
UniProtKB/Swiss-Prot for IL1RL1 Gene
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
Isoform B: Inhibits IL-33 signaling.