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IL1RL1 Gene

protein-coding   GIFtS: 64
GCID: GC02P102927

Interleukin 1 Receptor-Like 1

  See IL1RL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 1 Receptor-Like 11 2     ST2L2
Homolog Of Mouse Growth Stimulation-Expressed1 2     ST2V2
DER42 3     Growth Stimulation-Expressed2
ST22 3     Interleukin 1 Receptor-Related Protein2
T12 3     Interleukin-1 Receptor-Like 12
FIT-12     Protein ST23
IL33R2     

External Ids:    HGNC: 59981   Entrez Gene: 91732   Ensembl: ENSG000001156027   OMIM: 6012035   UniProtKB: Q016383   

Export aliases for IL1RL1 gene to outside databases

Previous GC identifers: GC02P100792 GC02P101380 GC02P102532 GC02P102549 GC02P102386 GC02P102294 GC02P096692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL1RL1 Gene:
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in
mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function
of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and
interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome
2q12. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1RL1 Gene:
IL1RL1 (interleukin 1 receptor-like 1) is a protein-coding gene. Diseases associated with IL1RL1 include allergic conjunctivitis, and yellow fever. GO annotations related to this gene include interleukin-1 receptor activity and receptor signaling protein activity. An important paralog of this gene is IL1RL2.

UniProtKB/Swiss-Prot: ILRL1_HUMAN, Q01638
Function: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed
by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell
function

Gene Wiki entry for IL1RL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1RL1 gene promoter:
         p53   MEF-2   FOXD3   STAT5A   HNF-1A   YY1   MEF-2A   HNF-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1RL1 promoter sequence
   Search Chromatin IP Primers for IL1RL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1RL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12

IL1RL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1RL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102927:  view genomic region     (about GC identifiers)

Start:
102,927,962 bp from pter      End:
102,968,497 bp from pter
Size:
40,536 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ILRL1_HUMAN, Q01638 (See protein sequence)
Recommended Name: Interleukin-1 receptor-like 1 precursor  
Size: 556 amino acids; 63358 Da
Subunit: Interacts with MYD88, IRAK1, IRAK4, and TRAF6
1 PDB 3D structure from and Proteopedia for IL1RL1:
4KC3 (3D)    
Secondary accessions: A8K6B3 Q53TU7 Q8NEJ3 Q9ULV7 Q9UQ44
Alternative splicing: 3 isoforms:  Q01638-1   Q01638-2   Q01638-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IL1RL1: NX_Q01638

Explore proteomics data for IL1RL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn54, Asn95, Asn101, Asn140, Asn191, Asn232, Asn254, Asn273
  • Modification sites at PhosphoSitePlus

  • See IL1RL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269337.1  NP_003847.2  NP_057316.3  

    ENSEMBL proteins: 
     ENSP00000233954   ENSP00000409437   ENSP00000310371   ENSP00000386618   ENSP00000391120  
     ENSP00000377052   ENSP00000384822  

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    IL1RL1 Antibody Products:

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    Cloud-Clone Corp. CLIAs for IL1RL1
    Search eBioscience for ELISAs for IL1RL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin-1 receptor-like 1
    Immunoglobulin-like family of IL-1 receptors

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold
     IPR015621 IL-1_rcpt_fam

    Graphical View of Domain Structure for InterPro Entry Q01638

    ProtoNet protein and cluster: Q01638

    3 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004075 Interleukin-1 receptor type I family signature


    UniProtKB/Swiss-Prot: ILRL1_HUMAN, Q01638
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    Find genes that share domains with IL1RL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ILRL1_HUMAN, Q01638
    Function: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed
    by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell
    function

         Genatlas biochemistry entry for IL1RL1:
    interleukin 1receptor-like 1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002113interleukin-33 binding IEA--
    GO:0002114interleukin-33 receptor activity IEA--
    GO:0004896cytokine receptor activity TAS10191101
    GO:0004908interleukin-1 receptor activity IEA--
    GO:0005057receptor signaling protein activity TAS1482686
         
    Find genes that share ontologies with IL1RL1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il1rl1):
     endocrine/exocrine gland  hematopoietic system  immune system  normal 

    Find genes that share phenotypes with IL1RL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL1RL1: Il1rl1tm1Brl Il1rl1tm1Anjm Il1rl1tm1Aki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL1RL1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1RL1

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    miRTarBase miRNAs that target IL1RL1:
    hsa-mir-26b-5p (MIRT029172)

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    1 qRT-PCR Assays for microRNA that regulate IL1RL1:
    hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL1RL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL1RL1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ILRL1_HUMAN, Q01638: Isoform C: Cell membrane
    ILRL1_HUMAN, Q01638: Isoform B: Secreted
    ILRL1_HUMAN, Q01638: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton2
    cytosol2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL1RL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL1RL1 About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44
    2TRAF Pathway
    Toll-Like Receptors Pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL1RL1
        IL-1 Family Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IL1RL1
        Toll-Like Receptors Pathway



        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1RL1: 
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL1RL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for IL1RL1 (Q016381, 3 ENSP000002339544) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL33O957601, 3, ENSP000003708424EBI-993762,EBI-724057 I2D: score=4 STRING: ENSP00000370842
    TMED1Q134453, ENSP000002148694I2D: score=3 STRING: ENSP00000214869
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=1 STRING: ENSP00000072516
    SIRT6Q8N6T73, ENSP000003373324I2D: score=1 STRING: ENSP00000337332
    TIRAPP587533, ENSP000003764454I2D: score=1 STRING: ENSP00000376445
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002826negative regulation of T-helper 1 type immune response IEA--
    GO:0006955immune response NAS10527832
    GO:0007165signal transduction TAS1482686
    GO:0032689negative regulation of interferon-gamma production IEA--
    GO:0032754positive regulation of interleukin-5 production IEA--

    Find genes that share ontologies with IL1RL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL1RL1 (ILRL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL1RL1 gene (4 alternative transcripts): 
    NM_001282408.1  NM_003856.3  NM_016232.4  NM_173459.1  

    Unigene Cluster for IL1RL1:

    Interleukin 1 receptor-like 1
    Hs.66  [show with all ESTs]
    Unigene Representative Sequence: BC030975
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233954(uc002tbu.1) ENST00000473175 ENST00000447231 ENST00000311734(uc010ywa.2 uc002tbv.3)
    ENST00000463990 ENST00000409584 ENST00000482701 ENST00000427077 ENST00000393393
    ENST00000404917
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate IL1RL1:
    hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL1RL1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat IL1RL1

    Additional mRNA sequence: 

    AB012701.3 AB029084.1 AK291578.1 AK303389.1 AL117622.1 BC012580.1 BC030975.1 D12763.1 
    EU181431.1 EU181432.1 

    11 DOTS entries:

    DT.113041  DT.92421864  DT.100767326  DT.100767328  DT.100651407  DT.121008706  DT.95213246  DT.99971740 
    DT.121008689  DT.92065193  DT.95131904 

    Selected AceView cDNA sequences (see all 95):

    BU689121 AL553735 AL117622 BU687542 NM_016232 BM985123 BU753582 BC030975 
    NM_003856 BX335431 BM972672 NM_173459 BQ012846 AI188516 AL576676 AA309431 
    BU688228 BG623224 AA677135 AA044313 AL544222 CB997126 BQ012352 AA320002 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
    SP1:        -     -     -                 -                 -                       -     -                     
    SP2:                                      -                                                                     
    SP3:                                      -                 -                                                   
    SP4:                          -                                                                                 


    ECgene alternative splicing isoforms for IL1RL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL1RL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL1RL1 Expression
    About this image


    IL1RL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
             Alveolar type II cells
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mast cell progenitor cells Hematopoietic Bone Marrow
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Placenta (Extraembryonic Tissues)
    IL1RL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL1RL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.66

    UniProtKB/Swiss-Prot: ILRL1_HUMAN, Q01638
    Tissue specificity: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small
    intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more
    abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and
    skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1RL1: 
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IL1RL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL1RL1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1rl11 , 5 interleukin 1 receptor-like 11, 5 75.23(n)1
    67.27(a)1
      1 (19.19 cM)5
    170821  NM_001025602.21  NP_001020773.11 
     404295705 
    chicken
    (Gallus gallus)
    Aves IL1RL11 interleukin 1 receptor-like 1 55.51(n)
    43.47(a)
      374136  NM_204275.2  NP_989606.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL1RL16
    interleukin 1 receptor-like 1
    37(a)
    1 ↔ 1
    GL343243.1(1635929-1658987)


    ENSEMBL Gene Tree for IL1RL1 (if available)
    TreeFam Gene Tree for IL1RL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL1RL1 gene
    IL1RL22  IL1RAPL22  IL1RAPL12  IL1RAP2  IL18RAP2  IL18R12  IL1R22  IL1R12  
    2 SIMAP similar genes for IL1RL1 using alignment to 6 protein entries:     ILRL1_HUMAN (see all proteins):
    IL1R1    IL18R1

    Find genes that share paralogs with IL1RL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL1RL1 (see all 1112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65431141,2
    C,A--102925994(+) AAAAAC/ACCAAA 1 -- us2k1 trp33Minor allele frequency- A:0.17WA NA 6
    rs2020711501,2
    C--102925994(+) AAACC-/CAAAAA 1 -- us2k10--------
    rs794955101,2
    C--102926212(+) AATAAA/GTGATT 1 -- us2k10--------
    rs1894268171,2
    --102926236(+) AGTCAC/TAGTCC 1 -- us2k10--------
    rs621517011,2
    C,F--102926261(+) TAGTAC/TGCAAA 1 -- us2k16Minor allele frequency- T:0.10NA CSA WA 246
    rs1820263591,2
    --102926262(+) AGTACA/GCAAAT 1 -- us2k10--------
    rs1167239631,2
    F--102926287(+) CTCCTC/TGATGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1852241571,2
    --102926302(+) TTTCAC/TCTTTT 1 -- us2k10--------
    rs67213461,2
    C,A,H--102926320(+) GTGACC/TCTAGG 1 -- us2k19Minor allele frequency- T:0.44NA WA EA 370
    rs124708641,2
    C,F,A,H--102926362(+) GGGACG/AAGCGT 1 -- us2k19Minor allele frequency- A:0.31NA WA EA 370

    HapMap Linkage Disequilibrium report for IL1RL1 (102927962 - 102968497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for IL1RL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1258097CNV Deletion17803354
    esv2673990CNV Deletion23128226
    esv2585327CNV Deletion19546169
    nsv820800CNV Duplication20802225
    nsv829585CNV Loss20364138

    Human Gene Mutation Database (HGMD): IL1RL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1RL1
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1RL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601203    OMIM disorders: --

    2 diseases for IL1RL1:    
    About MalaCards
    allergic conjunctivitis    yellow fever

    1 disease from the University of Copenhagen DISEASES database for IL1RL1:
    Asthma

    Find genes that share disorders with IL1RL1           About GenesLikeMe

    6 Novoseek inferred disease relationships for IL1RL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 39.8 10 17623648 (2), 9207179 (2), 20477519 (2), 18955562 (1) (see all 6)
    asthma 28.1 35 19254249 (5), 17623648 (2), 12372135 (1), 11463601 (1)
    dermatitis atopic 27.3 1 16118232 (1)
    glioblastoma 17.8 5 12492487 (2), 10936050 (1)
    tumors 3.42 1 14555548 (1)
    necrosis 0.192 2 14555548 (1), 19889931 (1)

    Genetic Association Database (GAD): IL1RL1
    Human Genome Epidemiology (HuGE) Navigator: IL1RL1 (23 documents)

    Export disorders for IL1RL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL1RL1 gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with IL1RL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. (PubMed id 16286016)1, 2, 3 Schmitz J....Kastelein R.A. (Immunity 2005)
    2. Nucleotide sequence of a complementary DNA for human ST2. (PubMed id 1482686)1, 2, 3 Tominaga S....Tetsuka T. (Biochim. Biophys. Acta 1992)
    3. Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. (PubMed id 11478810)1, 2, 9 Tago K....Tominaga S. (Biochem. Biophys. Res. Commun. 2001)
    4. Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM. (PubMed id 10527832)1, 2, 9 Tominaga S....Komatsu N. (Biochem. Biophys. Res. Commun. 1999)
    5. The cloning and nucleotide sequence of human ST2L cDNA. (PubMed id 10936050)1, 2, 9 Li H....Yanagisawa K. (Genomics 2000)
    6. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. (PubMed id 19671251)1, 4, 9 Castano R....Desrosiers M. (amp 2009)
    7. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)1, 3, 9 Dale M. and Nicklin M.J. (Genomics 1999)
    8. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. (PubMed id 21804549)1, 4 Torgerson D.G....Nicolae D.L. (Nat. Genet. 2011)
    9. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    10. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. (PubMed id 19910030)1, 4 Wu H....London S.J. (J. Allergy Clin. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9173 HGNC: 5998 AceView: IL1RL1 Ensembl:ENSG00000115602 euGenes: HUgn9173
    ECgene: IL1RL1 H-InvDB: IL1RL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL1RL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL1RL1 gene:
    Search GeneIP for patents involving IL1RL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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