Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL1RAPL2 Gene

Aliases for IL1RAPL2 Gene

  • Interleukin 1 Receptor Accessory Protein-Like 2 2 3
  • Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 1 3 4
  • IL-1 Receptor Accessory Protein-Like 2 3 4
  • IL1RAPL-2-Related Protein 3 4
  • IL1RAPL-2 3 4
  • TIGIRR-1 3 4
  • IL-1R-9 3 4
  • IL-1R9 3 4
  • IL1R9 3 4
  • Interleukin 1 Receptor 9 3
  • Interleukin-1 Receptor 9 4
  • IL-1-RAPL-2 4
  • IL-1RAPL-2 4

External Ids for IL1RAPL2 Gene

Previous GeneCards Identifiers for IL1RAPL2 Gene

  • GC0XP099752
  • GC0XP101359
  • GC0XP101936
  • GC0XP103212
  • GC0XP102582
  • GC0XP103617
  • GC0XP103811
  • GC0XP093435

Summaries for IL1RAPL2 Gene

Entrez Gene Summary for IL1RAPL2 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RAPL2 Gene

IL1RAPL2 (Interleukin 1 Receptor Accessory Protein-Like 2) is a Protein Coding gene. Diseases associated with IL1RAPL2 include cinca syndrome and cold urticaria. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RAP.

Gene Wiki entry for IL1RAPL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RAPL2 Gene

Genomics for IL1RAPL2 Gene

Regulatory Elements for IL1RAPL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL1RAPL2 Gene

Chromosome:
X
Start:
104,566,199 bp from pter
End:
105,769,729 bp from pter
Size:
1,203,531 bases
Orientation:
Plus strand

Genomic View for IL1RAPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1RAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RAPL2 Gene

Proteins for IL1RAPL2 Gene

  • Protein details for IL1RAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP60-IRPL2_HUMAN
    Recommended name:
    X-linked interleukin-1 receptor accessory protein-like 2
    Protein Accession:
    Q9NP60
    Secondary Accessions:
    • Q2M3U3
    • Q9NZN0

    Protein attributes for IL1RAPL2 Gene

    Size:
    686 amino acids
    Molecular mass:
    78670 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL1RAPL2 Gene

Proteomics data for IL1RAPL2 Gene at MOPED

Post-translational modifications for IL1RAPL2 Gene

  • Glycosylation at Asn 63, Asn 120, Asn 136, Asn 211, and Asn 328
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1RAPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL1RAPL2 (IL-1 RAPL2/IL-1 R9)

No data available for DME Specific Peptides for IL1RAPL2 Gene

Domains & Families for IL1RAPL2 Gene

Gene Families for IL1RAPL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP60

UniProtKB/Swiss-Prot:

IRPL2_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RAPL2: view

Function for IL1RAPL2 Gene

Gene Ontology (GO) - Molecular Function for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity TAS 10757639
GO:0004910 interleukin-1, Type II, blocking receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IL1RAPL2: view
genes like me logo Genes that share phenotypes with IL1RAPL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1RAPL2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL1RAPL2 Gene

Localization for IL1RAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RAPL2 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL1RAPL2: view

No data available for Subcellular locations from COMPARTMENTS for IL1RAPL2 Gene

Pathways & Interactions for IL1RAPL2 Gene

SuperPathways for IL1RAPL2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IL1RAPL2 Gene

Gene Ontology (GO) - Biological Process for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007417 central nervous system development TAS 10757639
GO:0019221 cytokine-mediated signaling pathway TAS 10757639
genes like me logo Genes that share ontologies with IL1RAPL2: view

No data available for Pathways by source and SIGNOR curated interactions for IL1RAPL2 Gene

Drugs & Compounds for IL1RAPL2 Gene

(53) Drugs for IL1RAPL2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 411
Amphotericin B Approved, Investigational Pharma 114
Anakinra Approved Pharma IL-1 receptor antagonist 0
Aspirin Approved Pharma Channel blocker 971
Chloramphenicol Approved Pharma 6

(51) Additional Compounds for IL1RAPL2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,25 DIHYDROXY VITAMIN D3
11beta-Hydroxysteroid
12-O-Tetradecanoylphorbol 13-acetate
6-ketoprostaglandin f1alpha
Actinomycin D
genes like me logo Genes that share compounds with IL1RAPL2: view

Transcripts for IL1RAPL2 Gene

mRNA/cDNA for IL1RAPL2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1RAPL2 Gene

Interleukin 1 receptor accessory protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1RAPL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAPL2 Gene

No ASD Table

Relevant External Links for IL1RAPL2 Gene

GeneLoc Exon Structure for
IL1RAPL2
ECgene alternative splicing isoforms for
IL1RAPL2

Expression for IL1RAPL2 Gene

mRNA expression in normal human tissues for IL1RAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RAPL2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9).

Protein differential expression in normal tissues from HIPED for IL1RAPL2 Gene

This gene is overexpressed in Ovary (53.9) and Heart (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1RAPL2 Gene



SOURCE GeneReport for Unigene cluster for IL1RAPL2 Gene Hs.675519

mRNA Expression by UniProt/SwissProt for IL1RAPL2 Gene

Q9NP60-IRPL2_HUMAN
Tissue specificity: Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.
genes like me logo Genes that share expression patterns with IL1RAPL2: view

Protein tissue co-expression partners for IL1RAPL2 Gene

Primer Products

In Situ Assay Products

Orthologs for IL1RAPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL1RAPL2 35
  • 93.75 (n)
  • 96.28 (a)
IL1RAPL2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1RAPL2 35
  • 94.36 (n)
  • 95.34 (a)
IL1RAPL2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1rapl2 35
  • 91.69 (n)
  • 94.46 (a)
Il1rapl2 16
Il1rapl2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1rapl2 35
  • 91.25 (n)
  • 94.61 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1RAPL2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RAPL2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1RAPL2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1RAPL2 35
  • 82.02 (n)
  • 85.42 (a)
IL1RAPL2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il1rapl2 35
  • 73.81 (n)
  • 75.51 (a)
zebrafish
(Danio rerio)
Actinopterygii il1rapl2 35
  • 65.59 (n)
  • 66.08 (a)
il1rapl2 36
  • 65 (a)
OneToOne
Species with no ortholog for IL1RAPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RAPL2 Gene

ENSEMBL:
Gene Tree for IL1RAPL2 (if available)
TreeFam:
Gene Tree for IL1RAPL2 (if available)

Paralogs for IL1RAPL2 Gene

Paralogs for IL1RAPL2 Gene

(3) SIMAP similar genes for IL1RAPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL1RAPL2: view

Variants for IL1RAPL2 Gene

Sequence variations from dbSNP and Humsavar for IL1RAPL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs618 -- 104,807,400(-) CCTGC(A/G)GGGGT intron-variant
rs655 -- 105,655,887(+) tttta(A/T)acagg intron-variant
rs656 -- 105,655,957(+) TCCTT(C/T)GAGTT intron-variant
rs169775 -- 105,580,764(+) CTTTA(A/G)AATGA intron-variant
rs172387 -- 105,657,976(-) TTTTT(A/C/T)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RAPL2 Gene

Variant ID Type Subtype PubMed ID
esv2670371 CNV Deletion 23128226
nsv521379 CNV Loss 19592680
esv259608 OTHER Complex 20981092
esv259738 OTHER Complex 20981092
esv1007229 CNV Insertion 20482838
nsv425150 CNV Insertion 16902084
dgv2461e1 CNV Complex 17122850
esv2676748 CNV Deletion 23128226
esv22969 CNV Loss 19812545
esv1011056 CNV Loss 20482838
esv1236936 CNV Insertion 17803354
nsv7020 CNV Insertion 18451855
esv2740367 CNV Deletion 23290073
nsv482958 CNV Loss 15286789
esv271289 CNV Insertion 20981092
esv2752312 CNV Gain 17911159

Variation tolerance for IL1RAPL2 Gene

Residual Variation Intolerance Score: 43.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RAPL2 Gene

HapMap Linkage Disequilibrium report
IL1RAPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RAPL2 Gene

Disorders for IL1RAPL2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IL1RAPL2 Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
cinca syndrome
  • chronic infantile neurological cutaneous articular syndrome
cold urticaria
  • cold contact urticaria
familial cold autoinflammatory syndrome
  • familial cold urticaria
wells syndrome
  • bullous cellulitis with eosinophilia
anterior scleritis
- elite association

Relevant External Links for IL1RAPL2

Genetic Association Database (GAD)
IL1RAPL2
Human Genome Epidemiology (HuGE) Navigator
IL1RAPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1RAPL2
genes like me logo Genes that share disorders with IL1RAPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RAPL2 Gene

Publications for IL1RAPL2 Gene

  1. Respiratory symptoms and inflammatory responses to Difflam throat-spray intervention in half-marathon runners: a randomised controlled trial. (PMID: 18523036) Cox A.J. … Fricker P.A. (Br J Sports Med 2010) 23 67
  2. Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin, and insulin metabolism in active acromegaly. (PMID: 19880791) Ueland T. … Bollerslev J. (J. Clin. Endocrinol. Metab. 2010) 23 67
  3. Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. (PMID: 19883649) Waghray M. … Merchant J.L. (Gastroenterology 2010) 23 67
  4. Treatment with the PPARgamma agonist rosiglitazone downregulates interleukin-1 receptor antagonist in individuals with metabolic syndrome. (PMID: 19926782) Halvorsen B. … Aukrust P. (Eur. J. Endocrinol. 2010) 23 67
  5. Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study. (PMID: 20230273) Stenholm S. … Ferrucci L. (Rejuvenation Res 2010) 23 67

Products for IL1RAPL2 Gene

Sources for IL1RAPL2 Gene

Back to Top

Content