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Aliases for IL1RAPL2 Gene

Aliases for IL1RAPL2 Gene

  • Interleukin 1 Receptor Accessory Protein-Like 2 2 3
  • Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 1 3 4
  • IL-1 Receptor Accessory Protein-Like 2 3 4
  • IL1RAPL-2-Related Protein 3 4
  • IL1RAPL-2 3 4
  • TIGIRR-1 3 4
  • IL-1R-9 3 4
  • IL-1R9 3 4
  • IL1R9 3 4
  • X-Linked Interleukin-1 Receptor Accessory Protein-Like 2 3
  • Interleukin 1 Receptor 9 3
  • Interleukin-1 Receptor 9 4
  • IL-1-RAPL-2 4
  • IL-1RAPL-2 4

External Ids for IL1RAPL2 Gene

Previous GeneCards Identifiers for IL1RAPL2 Gene

  • GC0XP099752
  • GC0XP101359
  • GC0XP101936
  • GC0XP103212
  • GC0XP102582
  • GC0XP103617
  • GC0XP103811
  • GC0XP093435

Summaries for IL1RAPL2 Gene

Entrez Gene Summary for IL1RAPL2 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RAPL2 Gene

IL1RAPL2 (Interleukin 1 Receptor Accessory Protein-Like 2) is a Protein Coding gene. Diseases associated with IL1RAPL2 include anterior scleritis and hypermobility syndrome. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RAP.

Gene Wiki entry for IL1RAPL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RAPL2 Gene

Genomics for IL1RAPL2 Gene

Regulatory Elements for IL1RAPL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL1RAPL2 Gene

104,566,315 bp from pter
105,767,829 bp from pter
1,201,515 bases
Plus strand

Genomic View for IL1RAPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1RAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RAPL2 Gene

Proteins for IL1RAPL2 Gene

  • Protein details for IL1RAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X-linked interleukin-1 receptor accessory protein-like 2
    Protein Accession:
    Secondary Accessions:
    • Q2M3U3
    • Q9NZN0

    Protein attributes for IL1RAPL2 Gene

    686 amino acids
    Molecular mass:
    78670 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL1RAPL2 Gene

Proteomics data for IL1RAPL2 Gene at MOPED

Post-translational modifications for IL1RAPL2 Gene

  • Glycosylation at Asn63, Asn120, Asn136, Asn211, and Asn328
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1RAPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL1RAPL2 (IL-1 RAPL2/IL-1 R9)

No data available for DME Specific Peptides for IL1RAPL2 Gene

Domains for IL1RAPL2 Gene

Gene Families for IL1RAPL2 Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors

Graphical View of Domain Structure for InterPro Entry



  • Q9NP60
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RAPL2: view

Function for IL1RAPL2 Gene

Gene Ontology (GO) - Molecular Function for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity TAS 10757639
GO:0004910 interleukin-1, Type II, blocking receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IL1RAPL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1RAPL2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL1RAPL2 Gene

Localization for IL1RAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RAPL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL1RAPL2 Gene COMPARTMENTS Subcellular localization image for IL1RAPL2 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL1RAPL2: view

Pathways for IL1RAPL2 Gene

SuperPathways for IL1RAPL2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IL1RAPL2 Gene

Gene Ontology (GO) - Biological Process for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007417 central nervous system development TAS 10757639
GO:0019221 cytokine-mediated signaling pathway TAS 10757639
genes like me logo Genes that share ontologies with IL1RAPL2: view

No data available for Pathways by source for IL1RAPL2 Gene

Compounds for IL1RAPL2 Gene

(104) Novoseek inferred chemical compound relationships for IL1RAPL2 Gene

Compound -log(P) Hits PubMed IDs
anakinra 90.7 67
endotoxin 66.7 26
pge2 53.9 24
il 10 49.5 8
etanercept 47.8 6
genes like me logo Genes that share compounds with IL1RAPL2: view

Transcripts for IL1RAPL2 Gene

mRNA/cDNA for IL1RAPL2 Gene

(9) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1RAPL2 Gene

Interleukin 1 receptor accessory protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1RAPL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAPL2 Gene

No ASD Table

Relevant External Links for IL1RAPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL1RAPL2 Gene

mRNA expression in normal human tissues for IL1RAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RAPL2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.9).

Protein differential expression in normal tissues for IL1RAPL2 Gene

This gene is overexpressed in Ovary (53.9) and Heart (15.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL1RAPL2 Gene

SOURCE GeneReport for Unigene cluster for IL1RAPL2 Gene Hs.675519

mRNA Expression by UniProt/SwissProt for IL1RAPL2 Gene

Tissue specificity: Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.
genes like me logo Genes that share expressions with IL1RAPL2: view

Expression partners for IL1RAPL2 Gene

In Situ Assay Products

Orthologs for IL1RAPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL1RAPL2 35
  • 93.75 (n)
  • 96.28 (a)
  • 94 (a)
(Canis familiaris)
Mammalia IL1RAPL2 35
  • 94.36 (n)
  • 95.34 (a)
  • 95 (a)
(Mus musculus)
Mammalia Il1rapl2 35
  • 91.69 (n)
  • 94.46 (a)
Il1rapl2 16
Il1rapl2 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Il1rapl2 35
  • 91.25 (n)
  • 94.61 (a)
(Monodelphis domestica)
Mammalia IL1RAPL2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia IL1RAPL2 36
  • 88 (a)
(Pan troglodytes)
Mammalia IL1RAPL2 36
  • 99 (a)
(Gallus gallus)
Aves IL1RAPL2 35
  • 82.02 (n)
  • 85.42 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
-- 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il1rapl2 35
  • 73.81 (n)
  • 75.51 (a)
(Danio rerio)
Actinopterygii il1rapl2 35
  • 65.59 (n)
  • 66.08 (a)
il1rapl2 36
  • 65 (a)
Species with no ortholog for IL1RAPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RAPL2 Gene

Gene Tree for IL1RAPL2 (if available)
Gene Tree for IL1RAPL2 (if available)

Paralogs for IL1RAPL2 Gene

Paralogs for IL1RAPL2 Gene

Selected SIMAP similar genes for IL1RAPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL1RAPL2: view

Variants for IL1RAPL2 Gene

Sequence variations from dbSNP and Humsavar for IL1RAPL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs618 -- 104,807,400(-) CCTGC(A/G)GGGGT intron-variant
rs655 -- 105,655,887(+) tttta(A/T)acagg intron-variant
rs656 -- 105,655,957(+) TCCTT(C/T)GAGTT intron-variant
rs169775 -- 105,580,764(+) CTTTA(A/G)AATGA intron-variant
rs172387 -- 105,657,976(-) TTTTT(A/C/T)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RAPL2 Gene

Variant ID Type Subtype PubMed ID
esv2670371 CNV Deletion 23128226
nsv521379 CNV Loss 19592680
esv259608 OTHER Complex 20981092
esv259738 OTHER Complex 20981092
esv1007229 CNV Insertion 20482838
nsv425150 CNV Insertion 16902084
dgv2461e1 CNV Complex 17122850
esv2676748 CNV Deletion 23128226
esv22969 CNV Loss 19812545
esv1011056 CNV Loss 20482838
esv1236936 CNV Insertion 17803354
nsv7020 CNV Insertion 18451855
esv2740367 CNV Deletion 23290073
nsv482958 CNV Loss 15286789
esv271289 CNV Insertion 20981092
esv2752312 CNV Gain 17911159

Relevant External Links for IL1RAPL2 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RAPL2 Gene

Disorders for IL1RAPL2 Gene

(2) University of Copenhagen DISEASES for IL1RAPL2 Gene

(88) Novoseek inferred disease relationships for IL1RAPL2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 81.2 106
cinca syndrome 75.5 3
inflammation 73.6 52
rheumatoid arthritis 68.2 26
muckle-wells syndrome 67.4 1

Relevant External Links for IL1RAPL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL1RAPL2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IL1RAPL2 Gene

Publications for IL1RAPL2 Gene

  1. Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.3-Xp21.3 mental retardation. (PMID: 10757639) Jin H. … Roberts R.G. (Eur. J. Hum. Genet. 2000) 2 3 4
  2. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. (PMID: 10882729) Born T.L. … Sims J.E. (J. Biol. Chem. 2000) 3 4
  3. Computational identification, cloning, and characterization of IL- 1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3. (PMID: 11031108) Sana T.R. … Kastelein R.A. (Genomics 2000) 3 4
  4. IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system. (PMID: 11587848) Ferrante M.I. … Franco B. (Gene 2001) 3 4
  5. Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies. (PMID: 17265504) Grundtman C. … Lundberg I.E. (Arthritis Rheum. 2007) 3 23

Products for IL1RAPL2 Gene

Sources for IL1RAPL2 Gene

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