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Aliases for IL1RAPL2 Gene

Aliases for IL1RAPL2 Gene

  • Interleukin 1 Receptor Accessory Protein Like 2 2 3
  • Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 1 3 4
  • Interleukin 1 Receptor Accessory Protein-Like 2 3 5
  • IL-1 Receptor Accessory Protein-Like 2 3 4
  • IL1RAPL-2-Related Protein 3 4
  • IL1RAPL-2 3 4
  • TIGIRR-1 3 4
  • IL-1R-9 3 4
  • IL-1R9 3 4
  • IL1R9 3 4
  • Interleukin 1 Receptor 9 3
  • Interleukin-1 Receptor 9 4
  • IL-1-RAPL-2 4
  • IL-1RAPL-2 4

External Ids for IL1RAPL2 Gene

Previous GeneCards Identifiers for IL1RAPL2 Gene

  • GC0XP099752
  • GC0XP101359
  • GC0XP101936
  • GC0XP103212
  • GC0XP102582
  • GC0XP103617
  • GC0XP103811
  • GC0XP093435

Summaries for IL1RAPL2 Gene

Entrez Gene Summary for IL1RAPL2 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RAPL2 Gene

IL1RAPL2 (Interleukin 1 Receptor Accessory Protein Like 2) is a Protein Coding gene. Diseases associated with IL1RAPL2 include Cinca Syndrome and Rheumatoid Arthritis. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RAP.

Gene Wiki entry for IL1RAPL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RAPL2 Gene

Genomics for IL1RAPL2 Gene

Regulatory Elements for IL1RAPL2 Gene

Enhancers for IL1RAPL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL1RAPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL1RAPL2 Gene

104,566,199 bp from pter
105,769,729 bp from pter
1,203,531 bases
Plus strand

Genomic View for IL1RAPL2 Gene

Genes around IL1RAPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RAPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RAPL2 Gene

Proteins for IL1RAPL2 Gene

  • Protein details for IL1RAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X-linked interleukin-1 receptor accessory protein-like 2
    Protein Accession:
    Secondary Accessions:
    • Q2M3U3
    • Q9NZN0

    Protein attributes for IL1RAPL2 Gene

    686 amino acids
    Molecular mass:
    78670 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL1RAPL2 Gene

Proteomics data for IL1RAPL2 Gene at MOPED

Post-translational modifications for IL1RAPL2 Gene

  • Glycosylation at Asn 63, Asn 120, Asn 136, Asn 211, and Asn 328
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1RAPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL1RAPL2 (IL-1 RAPL2/IL-1 R9)

No data available for DME Specific Peptides for IL1RAPL2 Gene

Domains & Families for IL1RAPL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RAPL2: view

Function for IL1RAPL2 Gene

genes like me logo Genes that share phenotypes with IL1RAPL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL1RAPL2

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL1RAPL2 Gene

Localization for IL1RAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RAPL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL1RAPL2 Gene COMPARTMENTS Subcellular localization image for IL1RAPL2 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IL1RAPL2 Gene

Pathways & Interactions for IL1RAPL2 Gene

SuperPathways for IL1RAPL2 Gene

No Data Available

Interacting Proteins for IL1RAPL2 Gene

Gene Ontology (GO) - Biological Process for IL1RAPL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for IL1RAPL2 Gene

Drugs & Compounds for IL1RAPL2 Gene

(53) Drugs for IL1RAPL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(51) Additional Compounds for IL1RAPL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL1RAPL2: view

Transcripts for IL1RAPL2 Gene

mRNA/cDNA for IL1RAPL2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1RAPL2 Gene

Interleukin 1 receptor accessory protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAPL2 Gene

No ASD Table

Relevant External Links for IL1RAPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL1RAPL2 Gene

mRNA expression in normal human tissues for IL1RAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RAPL2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9).

Protein differential expression in normal tissues from HIPED for IL1RAPL2 Gene

This gene is overexpressed in Ovary (53.9) and Heart (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1RAPL2 Gene

SOURCE GeneReport for Unigene cluster for IL1RAPL2 Gene Hs.675519

mRNA Expression by UniProt/SwissProt for IL1RAPL2 Gene

Tissue specificity: Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.
genes like me logo Genes that share expression patterns with IL1RAPL2: view

Protein tissue co-expression partners for IL1RAPL2 Gene

Primer Products

Orthologs for IL1RAPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL1RAPL2 35
  • 93.75 (n)
  • 96.28 (a)
  • 94 (a)
(Canis familiaris)
Mammalia IL1RAPL2 35
  • 94.36 (n)
  • 95.34 (a)
  • 95 (a)
(Mus musculus)
Mammalia Il1rapl2 35
  • 91.69 (n)
  • 94.46 (a)
Il1rapl2 16
Il1rapl2 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Il1rapl2 35
  • 91.25 (n)
  • 94.61 (a)
(Monodelphis domestica)
Mammalia IL1RAPL2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia IL1RAPL2 36
  • 88 (a)
(Pan troglodytes)
Mammalia IL1RAPL2 36
  • 99 (a)
(Gallus gallus)
Aves IL1RAPL2 35
  • 82.02 (n)
  • 85.42 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
-- 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il1rapl2 35
  • 73.81 (n)
  • 75.51 (a)
(Danio rerio)
Actinopterygii il1rapl2 35
  • 65.59 (n)
  • 66.08 (a)
il1rapl2 36
  • 65 (a)
Species with no ortholog for IL1RAPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RAPL2 Gene

Gene Tree for IL1RAPL2 (if available)
Gene Tree for IL1RAPL2 (if available)

Paralogs for IL1RAPL2 Gene

Paralogs for IL1RAPL2 Gene

(3) SIMAP similar genes for IL1RAPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL1RAPL2: view

Variants for IL1RAPL2 Gene

Sequence variations from dbSNP and Humsavar for IL1RAPL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036592 A breast cancer sample
rs747670697 -- 104,668,843(+) CACCA(C/T)AGTGT intron-variant
rs747673445 -- 104,975,569(+) AACTT(-/A)AACAA intron-variant
rs747675966 -- 104,582,164(+) TGTAC(A/G)CAACT intron-variant
rs747676393 -- 104,998,982(+) TTTGT(A/C)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RAPL2 Gene

Variant ID Type Subtype PubMed ID
esv2670371 CNV Deletion 23128226
nsv521379 CNV Loss 19592680
esv259608 OTHER Complex 20981092
esv259738 OTHER Complex 20981092
esv1007229 CNV Insertion 20482838
nsv425150 CNV Insertion 16902084
dgv2461e1 CNV Complex 17122850
esv2676748 CNV Deletion 23128226
esv22969 CNV Loss 19812545
esv1011056 CNV Loss 20482838
esv1236936 CNV Insertion 17803354
nsv7020 CNV Insertion 18451855
esv2740367 CNV Deletion 23290073
nsv482958 CNV Loss 15286789
esv271289 CNV Insertion 20981092
esv2752312 CNV Gain 17911159

Variation tolerance for IL1RAPL2 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL1RAPL2 Gene

Disorders for IL1RAPL2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL1RAPL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cinca syndrome
  • chronic infantile neurological cutaneous articular syndrome
rheumatoid arthritis
  • rheumatoid arthritis, progression of
familial cold autoinflammatory syndrome
  • familial cold urticaria
cold urticaria
  • cold contact urticaria
wells syndrome
  • bullous cellulitis with eosinophilia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL1RAPL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL1RAPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RAPL2 Gene

Publications for IL1RAPL2 Gene

  1. Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.3-Xp21.3 mental retardation. (PMID: 10757639) Jin H. … Roberts R.G. (Eur. J. Hum. Genet. 2000) 2 3 4 67
  2. Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies. (PMID: 17265504) Grundtman C. … Lundberg I.E. (Arthritis Rheum. 2007) 3 23
  3. Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD). (PMID: 21384559) KantojAorvi K. … JAorvelAo I. (Autism Res 2011) 3
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. Respiratory symptoms and inflammatory responses to Difflam throat-spray intervention in half-marathon runners: a randomised controlled trial. (PMID: 18523036) Cox A.J. … Fricker P.A. (Br J Sports Med 2010) 23

Products for IL1RAPL2 Gene

Sources for IL1RAPL2 Gene