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Aliases for IL1RAPL2 Gene

Aliases for IL1RAPL2 Gene

  • Interleukin 1 Receptor Accessory Protein Like 2 2 3 5
  • Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 1 3 4
  • IL-1 Receptor Accessory Protein-Like 2 3 4
  • IL1RAPL-2-Related Protein 3 4
  • IL1RAPL-2 3 4
  • TIGIRR-1 3 4
  • IL-1R-9 3 4
  • IL-1R9 3 4
  • IL1R9 3 4
  • X-Linked Interleukin-1 Receptor Accessory Protein-Like 2 3
  • Interleukin 1 Receptor 9 3
  • Interleukin-1 Receptor 9 4
  • IL-1-RAPL-2 4
  • IL-1RAPL-2 4

External Ids for IL1RAPL2 Gene

Previous GeneCards Identifiers for IL1RAPL2 Gene

  • GC0XP099752
  • GC0XP101359
  • GC0XP101936
  • GC0XP103212
  • GC0XP102582
  • GC0XP103617
  • GC0XP103811
  • GC0XP093435

Summaries for IL1RAPL2 Gene

Entrez Gene Summary for IL1RAPL2 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RAPL2 Gene

IL1RAPL2 (Interleukin 1 Receptor Accessory Protein Like 2) is a Protein Coding gene. Diseases associated with IL1RAPL2 include Cinca Syndrome and Cold Urticaria. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RAPL1.

Gene Wiki entry for IL1RAPL2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RAPL2 Gene

Genomics for IL1RAPL2 Gene

Regulatory Elements for IL1RAPL2 Gene

Enhancers for IL1RAPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG104709 0.4 FANTOM5 1.8 +143.1 143133 0.3 PRDM1 IL1RAPL2 PHBP10 RPL18AP14
GH0XG104445 0.7 ENCODE dbSUPER 0.1 -120.4 -120365 0.2 GATA3 FOXA1 GC0XM104375 IL1RAPL2
GH0XG104430 0.7 ENCODE dbSUPER 0.1 -135.2 -135152 1.0 POLR2A FOS GC0XM104375 IL1RAPL2
GH0XG104434 0.5 dbSUPER 0.1 -130.5 -130531 2.9 POLR2A SMARCA4 SUPT5H RBFOX2 ENSG00000235946 GC0XM104375 IL1RAPL2
GH0XG104418 0.4 dbSUPER 0.1 -146.1 -146134 3.2 NFIB REST GC0XM104375 IL1RAPL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL1RAPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL1RAPL2 Gene

Chromosome:
X
Start:
104,566,199 bp from pter
End:
105,769,729 bp from pter
Size:
1,203,531 bases
Orientation:
Plus strand

Genomic View for IL1RAPL2 Gene

Genes around IL1RAPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RAPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RAPL2 Gene

Proteins for IL1RAPL2 Gene

  • Protein details for IL1RAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP60-IRPL2_HUMAN
    Recommended name:
    X-linked interleukin-1 receptor accessory protein-like 2
    Protein Accession:
    Q9NP60
    Secondary Accessions:
    • Q2M3U3
    • Q9NZN0

    Protein attributes for IL1RAPL2 Gene

    Size:
    686 amino acids
    Molecular mass:
    78670 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL1RAPL2 Gene

Post-translational modifications for IL1RAPL2 Gene

  • Glycosylation at isoforms=63, isoforms=120, posLast=136136, posLast=211211, and posLast=328328
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1RAPL2 Gene

Antibody Products

  • R&D Systems Antibodies for IL1RAPL2 (IL-1 RAPL2/IL-1 R9)

Protein Products

  • Cloud-Clone Corp. Proteins for IL1RAPL2

No data available for DME Specific Peptides for IL1RAPL2 Gene

Domains & Families for IL1RAPL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP60

UniProtKB/Swiss-Prot:

IRPL2_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RAPL2: view

Function for IL1RAPL2 Gene

Gene Ontology (GO) - Molecular Function for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity TAS 10757639
GO:0004910 interleukin-1, Type II, blocking receptor activity IEA --
genes like me logo Genes that share ontologies with IL1RAPL2: view
genes like me logo Genes that share phenotypes with IL1RAPL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL1RAPL2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IL1RAPL2 (IL-1 RAPL2/IL-1 R9)

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL1RAPL2 Gene

Localization for IL1RAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RAPL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1RAPL2 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL1RAPL2: view

Pathways & Interactions for IL1RAPL2 Gene

SuperPathways for IL1RAPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IL1RAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007417 central nervous system development TAS 10757639
GO:0019221 cytokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL1RAPL2: view

No data available for Pathways by source and SIGNOR curated interactions for IL1RAPL2 Gene

Drugs & Compounds for IL1RAPL2 Gene

(59) Drugs for IL1RAPL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(45) Additional Compounds for IL1RAPL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL1RAPL2: view

Transcripts for IL1RAPL2 Gene

mRNA/cDNA for IL1RAPL2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1RAPL2 Gene

Interleukin 1 receptor accessory protein-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IL1RAPL2 (IL-1 RAPL2/IL-1 R9)

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAPL2 Gene

No ASD Table

Relevant External Links for IL1RAPL2 Gene

GeneLoc Exon Structure for
IL1RAPL2
ECgene alternative splicing isoforms for
IL1RAPL2

Expression for IL1RAPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL1RAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RAPL2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9).

Protein differential expression in normal tissues from HIPED for IL1RAPL2 Gene

This gene is overexpressed in Ovary (53.9) and Heart (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1RAPL2 Gene



Protein tissue co-expression partners for IL1RAPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL1RAPL2 Gene:

IL1RAPL2

SOURCE GeneReport for Unigene cluster for IL1RAPL2 Gene:

Hs.675519

mRNA Expression by UniProt/SwissProt for IL1RAPL2 Gene:

Q9NP60-IRPL2_HUMAN
Tissue specificity: Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.

Evidence on tissue expression from TISSUES for IL1RAPL2 Gene

  • Nervous system(4.2)
  • Liver(4)
genes like me logo Genes that share expression patterns with IL1RAPL2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RAPL2 Gene

Orthologs for IL1RAPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1RAPL2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1RAPL2 34 35
  • 94.36 (n)
cow
(Bos Taurus)
Mammalia IL1RAPL2 34 35
  • 93.75 (n)
mouse
(Mus musculus)
Mammalia Il1rapl2 34 16 35
  • 91.69 (n)
rat
(Rattus norvegicus)
Mammalia Il1rapl2 34
  • 91.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RAPL2 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1RAPL2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1RAPL2 34 35
  • 82.02 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 87 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il1rapl2 34
  • 73.81 (n)
zebrafish
(Danio rerio)
Actinopterygii il1rapl2 34 35
  • 65.59 (n)
Species where no ortholog for IL1RAPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RAPL2 Gene

ENSEMBL:
Gene Tree for IL1RAPL2 (if available)
TreeFam:
Gene Tree for IL1RAPL2 (if available)

Paralogs for IL1RAPL2 Gene

Paralogs for IL1RAPL2 Gene

(3) SIMAP similar genes for IL1RAPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL1RAPL2: view

Variants for IL1RAPL2 Gene

Sequence variations from dbSNP and Humsavar for IL1RAPL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036592 A breast cancer sample
rs1000001535 -- 104,868,028(+) TAGGG(G/T)GTACT intron-variant
rs1000001648 -- 105,116,061(+) CGTGC(A/G)CAGCC intron-variant
rs1000004044 -- 104,880,414(+) CCATA(A/C)CATAG intron-variant
rs1000005274 -- 105,397,590(+) GTGAA(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RAPL2 Gene

Variant ID Type Subtype PubMed ID
dgv4601e59 CNV tandem duplication 20981092
esv1007229 CNV insertion 20482838
esv1011056 CNV loss 20482838
esv1236936 CNV insertion 17803354
esv22969 CNV loss 19812545
esv2670371 CNV deletion 23128226
esv2676748 CNV deletion 23128226
esv2740367 CNV deletion 23290073
esv2752312 CNV gain 17911159
esv2758881 CNV loss 17122850
esv3307013 CNV mobile element insertion 20981092
esv3366401 CNV insertion 20981092
esv3381909 CNV insertion 20981092
esv3421706 CNV duplication 20981092
esv3425411 CNV insertion 20981092
esv3435721 CNV insertion 20981092
nsv1110095 CNV deletion 24896259
nsv1110618 CNV duplication 24896259
nsv1125993 CNV tandem duplication 24896259
nsv1133769 CNV deletion 24896259
nsv1140054 CNV duplication 24896259
nsv1141699 CNV duplication 24896259
nsv1146821 CNV duplication 26484159
nsv1147000 CNV insertion 26484159
nsv1150470 CNV duplication 26484159
nsv1151622 CNV duplication 26484159
nsv425150 CNV insertion 16902084
nsv474659 CNV novel sequence insertion 20440878
nsv476440 CNV novel sequence insertion 20440878
nsv521379 CNV loss 19592680
nsv7020 CNV insertion 18451855
nsv957832 CNV insertion 24416366

Variation tolerance for IL1RAPL2 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RAPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1RAPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RAPL2 Gene

Disorders for IL1RAPL2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL1RAPL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cinca syndrome
  • chronic infantile neurological cutaneous articular syndrome
cold urticaria
  • cold contact urticaria
familial cold autoinflammatory syndrome
  • familial cold urticaria
anterior scleritis
joint disorders
  • arthropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL1RAPL2

Genetic Association Database (GAD)
IL1RAPL2
Human Genome Epidemiology (HuGE) Navigator
IL1RAPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1RAPL2
genes like me logo Genes that share disorders with IL1RAPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RAPL2 Gene

Publications for IL1RAPL2 Gene

  1. Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.3-Xp21.3 mental retardation. (PMID: 10757639) Jin H. … Roberts R.G. (Eur. J. Hum. Genet. 2000) 2 3 4 64
  2. Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies. (PMID: 17265504) Grundtman C. … Lundberg I.E. (Arthritis Rheum. 2007) 3 22 64
  3. IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system. (PMID: 11587848) Ferrante M.I. … Franco B. (Gene 2001) 3 4 64
  4. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. (PMID: 10882729) Born T.L. … Sims J.E. (J. Biol. Chem. 2000) 3 4 64
  5. Computational identification, cloning, and characterization of IL- 1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3. (PMID: 11031108) Sana T.R. … Kastelein R.A. (Genomics 2000) 3 4 64

Products for IL1RAPL2 Gene

Sources for IL1RAPL2 Gene

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