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IL1RAPL1 Gene

protein-coding   GIFtS: 57
GCID: GC0XP028605

Interleukin 1 Receptor Accessory Protein-Like 1

(Previous names: mental retardation, X-linked 34, mental retardation, X-linked...)
(Previous symbols: IL1RAPL, MRX34, MRX21, MRX10)
  See IL1RAPL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Interleukin 1 Receptor Accessory Protein-Like 11 2     OPHN42 3
MRX211 2 5     TIGIRR-22 3
MRX341 2 5     X-Linked Interleukin-1 Receptor Accessory Protein-Like 12 3
IL1RAPL1 2     IL1R82 5
MRX101 2     Mental Retardation, X-Linked 211
Mental Retardation, X-Linked 101 2     Mental Retardation, X-Linked 341
Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 22 3     Interleukin 1 Receptor-82
IL-1-RAPL-12 3     Interleukin-1 Receptor Accessory Protein-Like 12
IL-1RAPL-12 3     oligophrenin-42
IL1RAPL-12 3     Oligophrenin-43

External Ids:    HGNC: 59961   Entrez Gene: 111412   Ensembl: ENSG000001693067   OMIM: 3002065   UniProtKB: Q9NZN13   

Export aliases for IL1RAPL1 gene to outside databases

Previous GC identifiers: GC0XP028452 GC0XP028097 GC0XP027807 GC0XP027966 GC0XP028365 GC0XP026346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


Entrez Gene summary for IL1RAPL1 Gene:
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the
interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2
(IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked
non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental
retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal
memory system, which suggests a specialized role in the physiological processes underlying memory and learning
abilities. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1RAPL1 Gene:
IL1RAPL1 (interleukin 1 receptor accessory protein-like 1) is a protein-coding gene. Diseases associated with IL1RAPL1 include x-linked mental retardation 21, and mental retardation. GO annotations related to this gene include interleukin-1 binding and receptor binding. An important paralog of this gene is IL1R2.

UniProtKB/Swiss-Prot: IRPL1_HUMAN, Q9NZN1
Function: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type
voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic
differentiation and dendritic spine formation in neurons

Gene Wiki entry for IL1RAPL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1RAPL1 gene promoter:
         E2F-3a   E2F-4   E2F-5   p53   E2F-2   IRF-2   E2F-1   E2F   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL1RAPL1 promoter sequence
   Search Chromatin IP Primers for IL1RAPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1RAPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.1-p21.3   Ensembl cytogenetic band:  Xp21.3   HGNC cytogenetic band: Xp22.1-p21.3

IL1RAPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1RAPL1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP028605:  view genomic region     (about GC identifiers)

Start:
28,605,516 bp from pter      End:
29,974,840 bp from pter
Size:
1,369,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: IRPL1_HUMAN, Q9NZN1 (See protein sequence)
Recommended Name: Interleukin-1 receptor accessory protein-like 1 precursor  
Size: 696 amino acids; 79969 Da
Subunit: Homodimer. Interacts (calcium-independent) with NCS1. Interacts (via extracellular region) with PTPRD;
this interaction is required for IL1RAPL1-mediated synapse formation
1 PDB 3D structure from and Proteopedia for IL1RAPL1:
1T3G (3D)    
Secondary accessions: A0AVG4 Q9UJ53
Alternative splicing: 1 isoform:  Q9NZN1-1   

Explore the universe of human proteins at neXtProt for IL1RAPL1: NX_Q9NZN1

Explore proteomics data for IL1RAPL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn63, Asn122, Asn138, Asn213, Asn264, Asn331
  • Modification sites at PhosphoSitePlus

  • See IL1RAPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055086.1  
    ENSEMBL proteins: 
     ENSP00000368278   ENSP00000305200  

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                        IL1RAPL1 Antibodies

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold
     IPR015621 IL-1_rcpt_fam

    Graphical View of Domain Structure for InterPro Entry Q9NZN1

    ProtoNet protein and cluster: Q9NZN1

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB004075 Interleukin-1 receptor type I family signature


    UniProtKB/Swiss-Prot: IRPL1_HUMAN, Q9NZN1
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    Find genes that share domains with IL1RAPL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRPL1_HUMAN, Q9NZN1
    Function: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type
    voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic
    differentiation and dendritic spine formation in neurons

         Genatlas biochemistry entry for IL1RAPL1:
    interleukin 1,receptor accessory protein-like,expressed in the developing and post natal hippocampus and
    perception cortices,including the olfactory bulb (in mouse),potentially involved in the release of
    neurotransmitters that have an effect of synapse structure and plasticity

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ISS--
    GO:0005245voltage-gated calcium channel activity ISS--
    GO:0005515protein binding IPI12783849
    GO:0019966NOT interleukin-1 binding IDA12783849
         
    Find genes that share ontologies with IL1RAPL1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Il1rapl1):
     nervous system 

    Find genes that share phenotypes with IL1RAPL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il1rapl1tm1.1Hesk for IL1RAPL1

       genOway: Develop your customized and physiologically relevant rodent model for IL1RAPL1

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    CRISPR Knockouts: 
       OriGene CRISPR knockouts for IL1RAPL1

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    1 qRT-PCR Assays for microRNA that regulate IL1RAPL1:
    hsa-miR-1288
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from UniProtKB/Swiss-Prot
    IRPL1_HUMAN, Q9NZN1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon (By
    similarity). Cell projection, dendrite (By similarity). Note=May localize to the cell body and growth cones of
    dendrite-like processes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion2
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA12783849
    GO:0009986cell surface ISS--
    GO:0016021integral component of membrane IEA--
    GO:0030424axon IEA--

    Find genes that share ontologies with IL1RAPL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section







        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IL1RAPL1
    Interactions:

        GeneGlobe Interaction Network for IL1RAPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for IL1RAPL1 (Q9NZN13 ENSP000003052004) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCS1P621663, ENSP000003614754I2D: score=2 STRING: ENSP00000361475
    CFTRP135693I2D: score=1 
    PTPRDENSP000003488124STRING: ENSP00000348812
    PTPRFENSP000003530304STRING: ENSP00000353030
    PTPRSENSP000003499324STRING: ENSP00000349932
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007157heterophilic cell-cell adhesion ISS--
    GO:0007165signal transduction IEA--
    GO:0010975regulation of neuron projection development ISS--
    GO:0030182neuron differentiation ISS--
    GO:0045920negative regulation of exocytosis IDA12783849

    Find genes that share ontologies with IL1RAPL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL1RAPL1 (IRPL1)

    1 Novoseek inferred chemical compound relationship for IL1RAPL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 53.4 4 10757639 (2), 15300857 (1), 19859888 (1)



    Find genes that share compounds with IL1RAPL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for IL1RAPL1 gene (2 alternative transcripts): 
    NM_014271.3  XM_005274441.1  

    Unigene Cluster for IL1RAPL1:

    Interleukin 1 receptor accessory protein-like 1
    Hs.658912  [show with all ESTs]
    Unigene Representative Sequence: AJ243874
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378993(uc004dby.2) ENST00000302196
    miRNA
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    hsa-miR-1288
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB102650.1 AF181284.1 AF284435.1 AF533682.1 AJ243874.1 AK307080.1 BC126345.1 BC126347.1 

    1 DOTS entry:

    DT.92062560 

    3 AceView cDNA sequences:

    BP348870 NM_014271 BP361613 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1RAPL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCGGCCA
    IL1RAPL1 Expression
    About this image

    IL1RAPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL1RAPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658912

    UniProtKB/Swiss-Prot: IRPL1_HUMAN, Q9NZN1
    Tissue specificity: Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus,
    corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate,
    testis, small intestine, placenta, colon and fetal liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of chordates.

    Orthologs for IL1RAPL1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1rapl11 , 5 interleukin 1 receptor accessory protein-like 11, 5 92.39(n)1
    98.56(a)1
      X (39.89 cM)5
    3314611  NM_001160403.11  NP_001153875.11 
     867408705 
    chicken
    (Gallus gallus)
    Aves IL1RAPL11 interleukin 1 receptor accessory protein-like 1 85.97(n)
    94.68(a)
      427993  XM_425563.4  XP_425563.3 
    lizard
    (Anolis carolinensis)
    Reptilia IL1RAPL16
    interleukin 1 receptor accessory protein-like 1
    99(a)
    1 ↔ 1
    3(129628738-129691533)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il1rapl11 interleukin 1 receptor accessory protein-like 1 81.32(n)
    90.66(a)
      100486886  XM_002933614.2  XP_002933660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.292322 Transcribed sequence with weak similarity to protein more 79.02(n)    57064662 


    ENSEMBL Gene Tree for IL1RAPL1 (if available)
    TreeFam Gene Tree for IL1RAPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for IL1RAPL1 gene
    IL1R22  IL1RL22  IL1RAPL22  IL1RL12  IL1RAP2  IL18RAP2  IL18R12  IL1R12  
    2 SIMAP similar genes for IL1RAPL1 using alignment to 3 protein entries:     IRPL1_HUMAN (see all proteins):
    IL1RAPL2    IL1RAP

    Find genes that share paralogs with IL1RAPL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for IL1RAPL1 (see all 19120)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876010171,2
    Cuntested129291168(+) CCACTA/C/TGGGAG 1 -- int10--------
    rs1819490521,2
    --28518771(+) TTGGAA/CATTTC 1 -- us2k10--------
    rs1445665751,2
    --28518817(+) CTCCCC/TGTCTA 1 -- us2k10--------
    rs1478511441,2
    --28518913(+) TTTATC/GTTGAT 1 -- us2k10--------
    rs1410822221,2
    --28518936(+) CCCCAA/CATTAA 1 -- us2k10--------
    rs736300571,2
    C--28519319(+) TACCGC/AATCCG 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1864294701,2
    --28519364(+) GTGTAC/TATCAA 1 -- us2k10--------
    rs1907997351,2
    --28519414(+) TCCCAA/GTGTAA 1 -- us2k10--------
    rs1114002531,2
    C,F--28519502(+) AATTCG/ATCTCA 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1815487531,2
    --28519532(+) TTTGCA/GGGGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL1RAPL1 (28605516 - 28855516 bp, first 250kb of IL1RAPL1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IL1RAPL1 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657228CNV Deletion23128226
    esv2678956CNV Deletion23128226
    esv2740043CNV Deletion23290073
    esv2670562CNV Deletion23128226
    esv2740044CNV Deletion23290073
    esv2740045CNV Deletion23290073
    esv2660380CNV Deletion23128226
    esv2676609CNV Deletion23128226
    esv270562CNV Insertion20981092
    nsv425042CNV Insertion16902084

    Human Gene Mutation Database (HGMD): IL1RAPL1
    Locus Specific Mutation Databases (LSDB): IL1RAPL1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1RAPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 300206   
    OMIM disorders: 300143  
    UniProtKB/Swiss-Prot: IRPL1_HUMAN, Q9NZN1
  • Mental retardation, X-linked 21 (MRX21) [MIM:300143]: A disorder characterized by significantly below
    average general intellectual functioning associated with impairments in adaptive behavior and manifested during
    the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental
    retardation, while syndromic mental retardation presents with associated physical, neurological and/or
    psychiatric manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for IL1RAPL1:    
    About MalaCards
    x-linked mental retardation 21    mental retardation    complex glycerol kinase deficiency    mental retardation, x-linked 29 and others
    mental retardation, x-linked

    2 inferred disease relationships from the University of Copenhagen DISEASES database for IL1RAPL1:
    Intellectual disability     Autistic disorder

    Find genes that share disorders with IL1RAPL1           About GenesLikeMe

    4 Novoseek inferred disease relationships for IL1RAPL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol kinase deficiency 93.6 3 10757639 (1), 15300857 (1), 19859888 (1)
    adrenal hypoplasia, congenital 91.8 3 10757639 (1), 12940459 (1), 19859888 (1)
    addisons disease 78.2 2 12940459 (2)
    mental retardation 69.8 13 10757639 (3), 16470793 (2), 15300857 (2), 10882729 (1) (see all 8)

    Genetic Association Database (GAD): IL1RAPL1
    Human Genome Epidemiology (HuGE) Navigator: IL1RAPL1 (7 documents)

    Export disorders for IL1RAPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for IL1RAPL1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with IL1RAPL1)

    1. Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.3-Xp21.3 mental retardation. (PubMed id 10757639)1, 2, 3, 9 Jin H.... Roberts R.G. (Eur. J. Hum. Genet. 2000)
    2. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. (PubMed id 10471494)1, 2, 3 Carrie A.... Chelly J. (Nat. Genet. 1999)
    3. IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. (PubMed id 12783849)1, 2, 9 Bahi N.... Chelly J. (Hum. Mol. Genet. 2003)
    4. Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. (PubMed id 15123616)1, 2, 9 Khan J.A.... Tong L. (J. Biol. Chem. 2004)
    5. A truncating mutation in the IL1RAPL1 gene is responsible for X- linked mental retardation in the MRX21 family. (PubMed id 16470793)1, 2, 9 Tabolacci E.... Neri G. (Am. J. Med. Genet. A 2006)
    6. Mutations in the calcium-related gene IL1RAPL1 are associated with autism. (PubMed id 18801879)1, 2, 9 Piton A.... Rouleau G.A. (Hum. Mol. Genet. 2008)
    7. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. (PubMed id 10882729)1, 2, 9 Born T.L....Sims J.E. (J. Biol. Chem. 2000)
    8. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    9. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    10. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (PubMed id 20838585)1, 4 Smith E.N....Murray S.S. (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11141 HGNC: 5996 AceView: IL1RAPL1 Ensembl:ENSG00000169306 euGenes: HUgn11141
    ECgene: IL1RAPL1 H-InvDB: IL1RAPL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1RAPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL1RAPL1 gene:
    Search GeneIP for patents involving IL1RAPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    CRISPR knockouts from OriGene)
    About This Section


     
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