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IL1RAP Gene

protein-coding   GIFtS: 69
GCID: GC03P190231

Interleukin 1 Receptor Accessory Protein

  See IL1RAP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 1 Receptor Accessory Protein1 2     IL1R32 3
Interleukin-1 Receptor 32 3     IL-1 Receptor Accessory Protein2 3
C3orf132 3     Interleukin-1 Receptor Accessory Protein2
IL-1R32 3     Interleukin-1 Receptor Accessory Protein Beta2
IL-1RAcP2 3     IL-1R-33

External Ids:    HGNC: 59951   Entrez Gene: 35562   Ensembl: ENSG000001960837   OMIM: 6026265   UniProtKB: Q9NPH33   

Export aliases for IL1RAP gene to outside databases

Previous GC identifers: GC03P187234 GC03P191494 GC03P191633 GC03P191552 GC03P191714 GC03P187631


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL1RAP Gene:
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or
stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This
gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1
receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive
genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one
membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase
induction or stress. (provided by RefSeq, Nov 2009)

GeneCards Summary for IL1RAP Gene:
IL1RAP (interleukin 1 receptor accessory protein) is a protein-coding gene. Diseases associated with IL1RAP include stromal keratitis. GO annotations related to this gene include interleukin-1 receptor activity and signal transducer activity. An important paralog of this gene is IL1RL2.

UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3
Function: Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1
receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling
involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR
domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to
interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex.
The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor.
Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of
secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by
secreted/soluble receptors

Gene Wiki entry for IL1RAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1RAP gene promoter:
         LHX3b/Lhx3b   AML1a   Tal-1beta   Egr-4   FOXJ2 (long isoform)   LHX3a/Lhx3a   FOXO1a   FOXJ2   MRF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL1RAP promoter sequence
   Search Chromatin IP Primers for IL1RAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1RAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q28

IL1RAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1RAP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P190231:  view genomic region     (about GC identifiers)

Start:
190,231,840 bp from pter      End:
190,375,843 bp from pter
Size:
144,004 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3 (See protein sequence)
Recommended Name: Interleukin-1 receptor accessory protein precursor  
Size: 570 amino acids; 65418 Da
Subunit: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a
non-signaling interleukin-1 receptor complex
2 PDB 3D structures from and Proteopedia for IL1RAP:
3O4O (3D)        4DEP (3D)    
Secondary accessions: B1NLD0 D3DNW0 O14915 Q86WJ7
Alternative splicing: 4 isoforms:  Q9NPH3-1   Q9NPH3-2   Q9NPH3-3   Q9NPH3-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IL1RAP: NX_Q9NPH3

Explore proteomics data for IL1RAP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn107, Asn111, Asn118, Asn196, Asn209, Asn299
  • Modification sites at PhosphoSitePlus

  • See IL1RAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001161400.1  NP_001161401.1  NP_001161402.1  NP_001161403.1  NP_002173.1  NP_608273.1  

    ENSEMBL proteins: 
     ENSP00000072516   ENSP00000401132   ENSP00000390541   ENSP00000389149   ENSP00000409352  
     ENSP00000391899   ENSP00000387371   ENSP00000416296   ENSP00000345829   ENSP00000314807  
     ENSP00000412008   ENSP00000414102   ENSP00000408893   ENSP00000412053  

    IL1RAP Human Recombinant Protein Products:

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    OriGene Purified Protein for IL1RAP
    OriGene Protein Over-expression Lysate for IL1RAP
    OriGene MassSpec for IL1RAP
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    Novus Biologicals IL1RAP Proteins
    Novus Biologicals IL1RAP Lysates
    Sino Biological Recombinant Protein for IL1RAP
    Sino Biological Cell Lysate for IL1RAP
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IL1RAP

     
    Search eBioscience for Proteins for IL1RAP 

    IL1RAP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL1RAP
    R&D Systems Antibodies for IL1RAP (IL-1 RAcP/IL-1 R3)
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    Abcam antibodies for IL1RAP
    Cloud-Clone Corp. Antibodies for IL1RAP
    ThermoFisher Antibodies for IL1RAP
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    IL1RAP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IL1RAP
    Cloud-Clone Corp. CLIAs for IL1RAP
    Search eBioscience for ELISAs for IL1RAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: IL-1 receptor accessory protein


    Selected InterPro protein domains (see all 6):
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold
     IPR015621 IL-1_rcpt_fam
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9NPH3

    ProtoNet protein and cluster: Q9NPH3

    2 Blocks protein domains:
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004075 Interleukin-1 receptor type I family signature


    UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    Find genes that share domains with IL1RAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1AP_HUMAN, Q9NPH3
    Function: Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1
    receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling
    involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR
    domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to
    interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex.
    The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor.
    Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of
    secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by
    secreted/soluble receptors
    Induction: Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment

         Genatlas biochemistry entry for IL1RAP:
    interleukin 1,receptor accessory protein,required for the recruitment of IRAK(1) to the interleukin 1 receptor
    complex,after induction by IL1A or IL1B

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS9065432
    GO:0004908interleukin-1 receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IL1RAP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL1RAP:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il1rap):
     immune system  integument 

    Find genes that share phenotypes with IL1RAP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il1raptm1Roml for IL1RAP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL1RAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL1RAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1RAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1RAP

    miRNA
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    miRTarBase miRNAs that target IL1RAP:
    hsa-mir-1228-3p (MIRT036392), hsa-mir-192-5p (MIRT026944), hsa-mir-375 (MIRT020058), hsa-mir-215-5p (MIRT024630), hsa-mir-204-5p (MIRT005831)

    Block miRNA regulation of human, mouse, rat IL1RAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL1RAP (see all 18):
    hsa-miR-411* hsa-miR-379* hsa-miR-520d-5p hsa-miR-522 hsa-miR-29a hsa-miR-29c hsa-miR-888* hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidIL1RAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL1RAP
    Predesigned siRNA for gene silencing in human, mouse, rat IL1RAP

    Gene Editing
    Products:
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    GenScript: all cDNA clones in your preferred vector (see all 6): IL1RAP (NM_002182)
    Sino Biological Human cDNA Clone for IL1RAP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1RAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1RAP

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL1RAP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL1AP_HUMAN, Q9NPH3: Isoform 1: Cell membrane; Single-pass type I membrane protein
    IL1AP_HUMAN, Q9NPH3: Isoform 2: Secreted
    IL1AP_HUMAN, Q9NPH3: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7775431

    Find genes that share ontologies with IL1RAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL1RAP About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL 1 beta dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    2NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways0.51
    Immune response IL 1 signaling pathway0.42
    IL-1 Family Signaling Pathways0.44
    3Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL-1 Signaling Pathway0.00
    4Interferon Signaling
    Cytokine Signaling in Immune system0.59
    5Th17 Differentiation
    Th17 Differentiation0.47


    Find genes that share SuperPaths with IL1RAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IL1RAP
        Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Th17 Differentiation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IL1RAP
        IL-1 Pathway

    5 GeneGo (Thomson Reuters) Pathways for IL1RAP
        Immune response Bacterial infections in normal airways
    Transcription NF-kB signaling pathway
    Bacterial infections in CF airways
    IL-1 beta-dependent CFTR expression
    Immune response IL-1 signaling pathway

    1 BioSystems Pathway for IL1RAP
        IL-1 Signaling Pathway



    3 Kegg Pathways  (Kegg details for IL1RAP):
        Cytokine-cytokine receptor interaction
    Apoptosis
    Inflammatory mediator regulation of TRP channels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1RAP: 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL1RAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL1RAP (Q9NPH32, 3 ENSP000000725164) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61875 I2D: score=3 
    IL1R1P147783, ENSP000002339464I2D: score=6 STRING: ENSP00000233946
    IRAK1P516173, ENSP000003589974I2D: score=5 STRING: ENSP00000358997
    IL1AP015833, ENSP000002633394I2D: score=2 STRING: ENSP00000263339
    PIK3R1P279863, ENSP000002743354I2D: score=2 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS7775431
    GO:0006954inflammatory response TAS9065432
    GO:0006955immune response TAS9065432
    GO:0007165signal transduction ----
    GO:0019221cytokine-mediated signaling pathway ----

    Find genes that share ontologies with IL1RAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL1RAP (IL1AP)

    5 Novoseek inferred chemical compound relationships for IL1RAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-nmma 36.9 1 10501519 (1)
    nitric oxide 25.3 3 8833198 (1), 8926042 (1), 10501519 (1)
    pge2 22.5 4 8384689 (1), 1836009 (1)
    tyrosine 0 1 12483539 (1)
    dexamethasone 0 1 7684399 (1)



    Find genes that share compounds with IL1RAP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL1RAP gene (6 alternative transcripts): 
    NM_001167928.1  NM_001167929.1  NM_001167930.1  NM_001167931.1  NM_002182.3  NM_134470.3  

    Unigene Cluster for IL1RAP:

    Interleukin 1 receptor accessory protein
    Hs.478673  [show with all ESTs]
    Unigene Representative Sequence: NM_001167928
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000072516(uc003fso.2 uc003fsp.2) ENST00000439062 ENST00000447382(uc010hzg.2 uc003fsm.2 uc003fsn.2)
    ENST00000422625 ENST00000465496 ENST00000422485(uc003fsk.3 uc003fsl.3)
    ENST00000434491 ENST00000422940 ENST00000413869 ENST00000342550 ENST00000317757(uc003fsq.3)
    ENST00000461629 ENST00000473566 ENST00000476929 ENST00000482913 ENST00000453359
    ENST00000412080 ENST00000443369
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    Selected qRT-PCR Assays for microRNAs that regulate IL1RAP (see all 18):
    hsa-miR-411* hsa-miR-379* hsa-miR-520d-5p hsa-miR-522 hsa-miR-29a hsa-miR-29c hsa-miR-888* hsa-miR-155*
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    GenScript: all cDNA clones in your preferred vector (see all 6): IL1RAP (NM_002182)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1RAP
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat IL1RAP
      QuantiFast Probe-based Assays in human, mouse, rat IL1RAP

    Additional mRNA sequence: 

    AB006537.1 AF029213.1 AF167343.1 AF487335.1 AF538732.1 AF538733.1 AF538734.1 AK095107.1 
    AK291669.1 BC016141.1 BC053621.1 EF591790.1 FJ998418.1 

    11 DOTS entries:

    DT.95370121  DT.99928349  DT.451695  DT.101984015  DT.97811801  DT.99936756  DT.100784427  DT.100773382 
    DT.97838473  DT.100701028  DT.100784426 

    Selected AceView cDNA sequences (see all 116):

    AA404531 AI082664 NM_134470 BM760155 BF589698 AF538733 BU188227 AL135064 
    AB006537 AI086058 CR591396 AF538730 AA401290 BU189361 AA256132 AF487335 
    CA441160 NM_002182 BE549836 AF029213 BU194356 AL543511 AF538731 BF059542 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAP (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -     -     -     -           -           -     -                             -                                                   
    SP2:              -     -     -     -           -           -     -                             -                       -                           
    SP3:              -     -     -     -     -     -           -     -                             -                                                   
    SP4:              -     -     -     -     -     -           -     -                             -                       -                           
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for IL1RAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL1RAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTTTGTA
    IL1RAP Expression
    About this image


    IL1RAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    IL1RAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL1RAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.478673

    UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3
    Tissue specificity: Detected in liver, skin, placenta, thymus and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1RAP: 
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              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IL1RAP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1rap1 , 5 interleukin 1 receptor accessory protein1, 5 86.33(n)1
    88.91(a)1
      16 (18.21 cM)5
    161801  NM_001159318.11  NP_001152790.11 
     265817045 
    chicken
    (Gallus gallus)
    Aves IL1RAP1 interleukin 1 receptor accessory protein 69.76(n)
    68.76(a)
      424908  XM_422719.4  XP_422719.3 
    lizard
    (Anolis carolinensis)
    Reptilia IL1RAP6
    interleukin 1 receptor accessory protein
    58(a)
    1 ↔ 1
    GL343386.1(589164-675639)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il1rap1 interleukin 1 receptor accessory protein 64.5(n)
    61.07(a)
      100216065  NM_001142051.1  NP_001135523.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01068246.16
    Uncharacterized protein
    36(a)
    1 ↔ 1
    15(44184123-44196691) ENSDARG00000091088


    ENSEMBL Gene Tree for IL1RAP (if available)
    TreeFam Gene Tree for IL1RAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL1RAP gene
    IL1RL22  IL1RAPL22  IL1RAPL12  IL18RAP2  IL18R12  IL1R22  IL1RL12  IL1R12  
    2 SIMAP similar genes for IL1RAP using alignment to 5 protein entries:     IL1AP_HUMAN (see all proteins):
    IL1RAPL2    IL1RAPL1

    Find genes that share paralogs with IL1RAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL1RAP (see all 3220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38364461,2
    C--187692315(-) AAAAA-/ACTCAT 6 -- int10--------
    rs725922971,2
    C--187761351(+) AAAAA-/A/GAWWAG 4 -- int10--------
    rs1419044361,2
    --190098302(+) CAGCGA/TTGGTT 6 -- us2k10--------
    rs1506294681,2
    --190098428(+) CTTCAA/GTGTCC 6 -- us2k10--------
    rs1825680781,2
    --190098494(+) AGTACA/GTGAGA 6 -- us2k10--------
    rs1396984761,2
    --190098524(+) ATGAAC/TGTCGA 6 -- us2k10--------
    rs1892209461,2
    --190098525(+) TGAACA/GTCGAG 6 -- us2k10--------
    rs1179866131,2
    --190098655(+) GAGGGT/CTACCT 6 -- us2k11Minor allele frequency- C:0.01EA 120
    rs730581391,2
    C,F--190098718(+) TGTGTA/CAATGC 6 -- us2k12Minor allele frequency- C:0.06WA 120
    rs1493621521,2
    --190098719(+) GTGTAA/GATGCT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL1RAP (190231840 - 190375843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IL1RAP (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1433093CNV Deletion17803354
    esv2440806CNV Deletion19546169
    esv4944CNV Deletion18987735
    esv2667728CNV Deletion23128226
    esv1980229CNV Deletion18987734
    esv4162CNV Deletion18987735
    esv1000745CNV Deletion20482838
    esv2677697CNV Deletion23128226
    esv2726383CNV Deletion23290073
    esv2726382CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1RAP
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1RAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602626    OMIM disorders: --

    1 disease for IL1RAP:    
    About MalaCards
    stromal keratitis


    Find genes that share disorders with IL1RAP           About GenesLikeMe

    8 Novoseek inferred disease relationships for IL1RAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 36.6 3 9415630 (1), 8938565 (1), 1426065 (1)
    inflammation 31.5 2 12781872 (1), 16973626 (1)
    rheumatoid arthritis 23.4 1 1386092 (1)
    bronchoalveolar lavage fluid 21.8 1 7797792 (1)
    arthritis 7.7 1 8617986 (1)
    osteoarthritis 1.74 1 1386092 (1)
    tumors 0.681 3 9415630 (1), 8938565 (1), 1426065 (1)
    mental retardation 0 1 12783849 (1)

    Genetic Association Database (GAD): IL1RAP
    Human Genome Epidemiology (HuGE) Navigator: IL1RAP (19 documents)

    Export disorders for IL1RAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL1RAP gene, integrated from 10 sources (see all 171):
    (articles sorted by number of sources associating them with IL1RAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping. (PubMed id 9479509)1, 2, 3, 9 Dale M.... Nicklin M.J.H. (Genomics 1998)
    2. The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. (PubMed id 9862719)1, 2, 9 Lang D....Martin M.U. (J. Immunol. 1998)
    3. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). (PubMed id 9065432)1, 3, 9 Wesche H....Martin M.U. (J. Biol. Chem. 1997)
    4. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. (PubMed id 9371760)1, 2, 9 Huang J.... Cao Z. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    5. IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. (PubMed id 10799889)1, 2, 9 Jensen L.E.... Whitehead A.S. (J. Immunol. 2000)
    6. Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis. (PubMed id 12781872)1, 2, 9 Jensen L.E. and Whitehead A.S. (Cell. Signal. 2003)
    7. A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687. (PubMed id 17949817)1, 2, 9 Lu H.L.... Ting L.P. (Mol. Immunol. 2008)
    8. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. (PubMed id 12530978)1, 2, 9 Smith D.E.... Sims J.E. (Immunity 2003)
    9. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (Obesity (Silver Spring) 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3556 HGNC: 5995 AceView: IL1RAP Ensembl:ENSG00000196083 euGenes: HUgn3556
    ECgene: IL1RAP Kegg: 3556 H-InvDB: IL1RAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL1RAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL1RAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL1RAP gene:
    Search GeneIP for patents involving IL1RAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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