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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1RAP Gene

protein-coding   GIFtS: 68
GCID: GC03P190231

interleukin 1 receptor accessory protein
 Explore 17 diseases affiliated with
IL1RAP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL1RAP    

Aliases
for IL1RAP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 1 Receptor Accessory Protein1 2     IL-1R32 3
C3orf131 2 3     IL-1 Receptor Accessory Protein2 3
IL-1RAcP1 2 3     Interleukin-1 Receptor Accessory Protein2
IL1R31 2 3     Interleukin-1 Receptor Accessory Protein Beta2
Interleukin-1 Receptor 32 3     IL-1R-33

External Ids:    HGNC: 59951   Entrez Gene: 35562   Ensembl: ENSG000001960837   OMIM: 6026265   UniProtKB: Q9NPH33   

Export aliases for IL1RAP gene to outside databases

Previous GC identifers: GC03P187234 GC03P191494 GC03P191633 GC03P191552 GC03P191714 GC03P187631


Summaries
for IL1RAP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL1RAP:
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress,
by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes
the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex
which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative
splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one
soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. (provided by
RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3
Function: Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor
complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the
recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the
receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding
of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated
through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3)
associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex
formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

Gene Wiki entry for IL1RAP


Genomic Views
for IL1RAP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1RAP gene promoter:
         LHX3b/Lhx3b   AML1a   Tal-1beta   Egr-4   FOXJ2 (long isoform)   LHX3a/Lhx3a   FOXO1a   FOXJ2   MRF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL1RAP promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1RAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1RAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q28

IL1RAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1RAP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P190231:  view genomic region     (about GC identifiers)

Start:
 190,231,840 bp from pter      End:
 190,375,843 bp from pter
Size:
 144,004 bases      Orientation:
 plus strand

Proteins
for IL1RAP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3 (See protein sequence)
Recommended Name: Interleukin-1 receptor accessory protein precursor  
Size: 570 amino acids; 65418 Da
Subunit: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a
non-signaling interleukin-1 receptor complex
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Subcellular location: Isoform 3: Secreted
2 PDB 3D structures from and Proteopedia for IL1RAP:
3O4O (3D)        4DEP (3D)    
Secondary accessions: B1NLD0 D3DNW0 O14915 Q86WJ7
Alternative splicing: 4 isoforms:  Q9NPH3-1   Q9NPH3-2   Q9NPH3-3   Q9NPH3-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IL1RAP: NX_Q9NPH3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPH3

    • IL1RAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001161400.1  NP_001161401.1  NP_001161402.1  NP_001161403.1  NP_002173.1  NP_608273.1  

    ENSEMBL proteins: 
     ENSP00000072516   ENSP00000401132   ENSP00000390541   ENSP00000389149   ENSP00000409352  
     ENSP00000391899   ENSP00000387371   ENSP00000416296   ENSP00000345829   ENSP00000314807  
     ENSP00000412008   ENSP00000414102   ENSP00000408893   ENSP00000412053  
    Reactome Protein details: Q9NPH3
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL1RAP (IL-1 RAcP/IL-1 R3)
    Enzo Life Sciences proteins for IL1RAP
    OriGene Purified Protein: IL1RAP
    OriGene Protein Over-expression Lysate (see all 2): IL1RAP
    OriGene Custom Protein Services for IL1RAP 
    GenScript Custom Purified and Recombinant Proteins Services for IL1RAP
    Novus Biologicals IL1RAP Proteins
    Novus Biologicals IL1RAP Lysates
    Sino Biological Recombinant Protein for IL1RAP
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IL1RAP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7775431


    IL1RAP for ontologies           About GeneDecksing



    IL1RAP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL1RAP (IL-1 RAcP/IL-1 R3)
    OriGene Antibodies (see all 2): IL1RAP
    OriGene Custom Antibody Services for IL1RAP 
    GenScript Custom Superior Antibodies Services for IL1RAP
    Novus Biologicals IL1RAP Antibodies
    Search for Antibodies for IL1RAP at Abcam  
    Uscn Antibodies for IL1RAP
    ThermoFisher Antibodies for IL1RAP

    Assay Products for IL1RAP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for IL1RAP (IL-1 RAcP/IL-1 R3)
    GenScript Custom Assay Services for IL1RAP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IL1RAP

    Protein Domains /
    Families
    for IL1RAP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL1RAP for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015621 IL1-receptor_fam
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9NPH3

    ProtoNet protein and cluster: Q9NPH3

    2 Blocks protein families:
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004075 Interleukin-1 receptor type I family signature


    UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    Function
    for IL1RAP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3
    Function: Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor
    complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the
    recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the
    receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding
    of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated
    through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3)
    associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex
    formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors
    Induction: Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment

         Genatlas biochemistry entry for IL1RAP:
    interleukin 1,receptor accessory protein,required for the recruitment of IRAK(1) to the interleukin 1 receptor
    complex,after induction by IL1A or IL1B

    miRNA
    Products:            		miRTarBase miRNAs that target IL1RAP:
    hsa-mir-204 (MIRT005831)

    OriGene 3'-UTR Clone (see all 2): IL1RAP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1RAP
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1RAP (see all 18):
    hsa-miR-411* hsa-miR-379* hsa-miR-520d-5p hsa-miR-522 hsa-miR-29a hsa-miR-29c hsa-miR-888* hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmid: IL1RAP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL1RAP (see all 7)
    OriGene shRNA RFP: IL1RAP
    OriGene siRNA: IL1RAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1RAP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IL1RAP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL1RAP (see all 11)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL1RAP (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): IL1RAP (NM_002182)
    Sino Biological Human cDNA Clone for IL1RAP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1RAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1RAP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IL1RAP
    Search LifeMap BioReagents cell lines for IL1RAP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1RAP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS9065432
    GO:0004908interleukin-1 receptor activity IEA--


    IL1RAP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IL1RAP:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Il1raptm1Roml for IL1RAP
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Il1rap):
     immune system  integument 

    IL1RAP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IL1RAP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response_Bacterial infections in normal airways
    		Immune response_Bacterial infections in normal airways1.00
    		IL-1 beta-dependent CFTR expression0.43
    		Bacterial infections in CF airways0.78
    2Immune response_IL-1 signaling pathway
    		Immune response_IL-1 signaling pathway1.00
    		Immune response IL-1 signaling pathway0.98
    3Transcription NF-kB signaling pathway
    		Transcription NF-kB signaling pathway1.00
    		Transcription_NF-kB signaling pathway0.85
    4IL-1 Signaling Pathway
    		IL-1 Signaling Pathway1.00
    		IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation0.54
    5Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for IL1RAP
        Transcription NF-kB signaling pathway
    Immune response IL-1 signaling pathway

    2 R&D Systems Pathways for IL1RAP
        Inflammasome Activation Pathways
    Th17 Differentiation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for IL1RAP
        IL-1 Pathway

    5 GeneGo (Thomson Reuters) Pathways for IL1RAP
        Immune response Bacterial infections in normal airways
    Transcription NF-kB signaling pathway
    Bacterial infections in CF airways
    IL-1 beta-dependent CFTR expression
    Immune response IL-1 signaling pathway

    1 BioSystems Pathway for IL1RAP 
        IL-1 Signaling Pathway

    5        Reactome Pathways for IL1RAP
        IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
    Interleukin-1 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    2         Kegg Pathways  (Kegg details for IL1RAP):
        Cytokine-cytokine receptor interaction
    Apoptosis


    IL1RAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1RAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/29 Interacting proteins for IL1RAP (Q9NPH32, 3 ENSP000000725164) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61875 I2D: score=3 
    IL1R1P147783, ENSP000002339464I2D: score=6 STRING: ENSP00000233946
    IRAK1P516173, ENSP000003589974I2D: score=5 STRING: ENSP00000358997
    IL1AP015833, ENSP000002633394I2D: score=2 STRING: ENSP00000263339
    PIK3R1P279863, ENSP000002743354I2D: score=2 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS7775431
    GO:0006954inflammatory response TAS9065432
    GO:0006955immune response TAS9065432
    GO:0007165signal transduction ----
    GO:0019221cytokine-mediated signaling pathway ----


    IL1RAP for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL1RAP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL1RAP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL1RAP
    5 Novoseek chemical compound relationships for IL1RAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-nmma 36.9 1 10501519 (1)
    nitric oxide 25.3 3 8833198 (1), 8926042 (1), 10501519 (1)
    pge2 22.5 4 8384689 (1), 1836009 (1)
    tyrosine 0 1 12483539 (1)
    dexamethasone 0 1 7684399 (1)

    Search CenterWatch for drugs/clinical trials and news about IL1RAP / IL1AP 

    Transcripts
    for IL1RAP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL1RAP gene (6 alternative transcripts): 
    NM_001167928.1  NM_001167929.1  NM_001167930.1  NM_001167931.1  NM_002182.3  NM_134470.3  

    Unigene Cluster for IL1RAP:

    Interleukin 1 receptor accessory protein
    Hs.478673  [show with all ESTs]
    Unigene Representative Sequence: NM_001167928
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000072516(uc003fso.2 uc003fsp.2) ENST00000439062 ENST00000447382(uc010hzg.2 uc003fsm.2 uc003fsn.2)
    ENST00000422625 ENST00000465496 ENST00000422485(uc003fsk.3 uc003fsl.3)
    ENST00000434491 ENST00000422940 ENST00000413869 ENST00000342550 ENST00000317757(uc003fsq.3)
    ENST00000461629 ENST00000473566 ENST00000476929 ENST00000482913 ENST00000453359
    ENST00000412080 ENST00000443369

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): IL1RAP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1RAP
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1RAP (see all 18):
    hsa-miR-411* hsa-miR-379* hsa-miR-520d-5p hsa-miR-522 hsa-miR-29a hsa-miR-29c hsa-miR-888* hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmid: IL1RAP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL1RAP (see all 7)
    OriGene shRNA RFP: IL1RAP
    OriGene siRNA: IL1RAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1RAP
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): IL1RAP (NM_002182)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1RAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1RAP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL1RAP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1RAP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1RAP

    Additional cDNA sequence: 

    AB006537.1 AF029213.1 AF167343.1 AF487335.1 AF538732.1 AF538733.1 AF538734.1 AK095107.1 
    AK291669.1 BC016141.1 BC053621.1 EF591790.1 FJ998418.1 

    11 DOTS entries:

    DT.95370121  DT.99928349  DT.451695  DT.101984015  DT.97811801  DT.99936756  DT.100784427  DT.100773382 
    DT.97838473  DT.100701028  DT.100784426 

    24/116 AceView cDNA sequences (see all 116):

    BF059542 CR591396 AF029213 BU188227 AA401290 BE549836 BG562435 AA256132 
    AA404531 AL543511 AI086058 AV654169 BF589698 BU189361 BX496958 AF538730 
    AV650065 AI082664 AF538731 NM_002182 AA256257 NM_134470 AB006537 BM760155 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAP (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -     -     -     -           -           -     -                             -                                                   
    SP2:              -     -     -     -           -           -     -                             -                       -                           
    SP3:              -     -     -     -     -     -           -     -                             -                                                   
    SP4:              -     -     -     -     -     -           -     -                             -                       -                           
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for IL1RAP

    Expression
    for IL1RAP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1RAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTTTTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL1RAP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    LungLung BudLung
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL1RAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL1RAP

    SOURCE GeneReport for Unigene cluster: Hs.478673

    UniProtKB/Swiss-Prot: IL1AP_HUMAN, Q9NPH3
    Tissue specificity: Detected in liver, skin, placenta, thymus and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL1RAP: 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for IL1RAP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL1RAP gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Il1rap1 , 5 interleukin 1 receptor accessory protein1, 5 86.33(n)1
    88.91(a)1    		   16 (18.21 cM)5
    161801  NM_001159318.11  NP_001152790.11 
     265817045 
    chicken
    (Gallus gallus)    		 Aves IL1RAP1 interleukin 1 receptor accessory protein 69.76(n)
    68.76(a)    		   424908  XM_422719.3  XP_422719.3 
    lizard
    (Anolis carolinensis)    		 Reptilia IL1RAP6
    		 --
    		 57(a)
    		 1 ↔ 1
    		 GL343386.1(613230-672538)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01068246.16
    		 --
    		 34(a)
    		 1 ↔ 1
    		 15(44184123-44196691)


    ENSEMBL Gene Tree for IL1RAP (if available)
    TreeFam Gene Tree for IL1RAP (if available) 

    Paralogs
    for IL1RAP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL1RAP gene
    IL1RAPL22  IL1RL22  IL1RAPL12  IL18RAP2  IL18R12  SIGIRR2  IL1R22  IL1RL12  
    IL1R12  
    2 SIMAP similar genes for IL1RAP using alignment to 5 protein entries:     IL1AP_HUMAN (see all proteins):
    IL1RAPL2    IL1RAPL1

    IL1RAP for paralogs           About GeneDecksing



    Genomic Variants
    for IL1RAP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2755 NCBI SNPs in IL1RAP are shown (see all 2755)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs730581391,2
    		C,--187630152(+) TGTGTA/CAATGC 6 -- us2k12Minor allele frequency- C:0.06WA 120
    rs98479361,2
    		C,F,A,H,--187630214(+) ATGAAT/AAATAA 6 -- us2k1 tfbs35Minor allele frequency- A:0.04EA NS NA WA 422
    rs42965701,2
    		C--187630805(+) GGTGCC/TTGAAC 6 -- us2k12Minor allele frequency- T:0.00NA 4
    rs117107801,2
    		H--187631081(+) atttaC/Gtcttg 6 -- us2k10--------
    rs748116781,2
    		--187631431(+) CAAGCC/GCGCAC 6 -- us2k10--------
    rs130917211,2
    		C--187631840(+) CGCGCC/TGCCGT 6 -- int11Minor allele frequency- T:0.00NA 2
    rs1137975301,2
    		C,--187632859(+) CAGCC-/AAAAAA 6 -- int11Minor allele frequency- A:0.50CSA 2
    rs791413021,2
    		F,--187633091(+) ATGTGG/ATGTCT 6 -- int11Minor allele frequency- A:0.02NA 120
    rs76300251,2
    		C,H,--187633312(+) TGAGAG/AGCAGA 6 -- int15Minor allele frequency- A:0.03EA NS WA 406
    rs76300341,2
    		C,F,A,H,--187633341(+) TGGAAG/ATTGCA 6 -- int121Minor allele frequency- A:0.22EA NS NA WA CSA 2096

    HapMap Linkage Disequilibrium report for IL1RAP (190231840 - 190375843 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for IL1RAP
         5 CNVs: 98570 91771 47999 43475 91772
         8 Indels: 40586 12364 91773 27252 46353 12365 42740 60447

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    Disorders / Diseases
    for IL1RAP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL1RAP for disorders           About GeneDecksing

    OMIM gene information: 602626    OMIM disorders: --

    17 diseases for IL1RAP:    About MalaCards
    type 2 diabetes mellitus    diabetes mellitus    inflammatory bowel disease    rheumatoid arthritis
    insulin resistance    keratitis    arthritis    osteoarthritis
    hepatitis b    endometriosis    hepatitis    retinitis
    melanoma    pancreatitis    leukemia    neuronitis
    bone fracture

    8 Novoseek disease relationships for IL1RAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 36.6 3 9415630 (1), 8938565 (1), 1426065 (1)
    inflammation 31.5 2 12781872 (1), 16973626 (1)
    rheumatoid arthritis 23.4 1 1386092 (1)
    bronchoalveolar lavage fluid 21.8 1 7797792 (1)
    arthritis 7.7 1 8617986 (1)
    osteoarthritis 1.74 1 1386092 (1)
    tumors 0.681 3 9415630 (1), 8938565 (1), 1426065 (1)
    mental retardation 0 1 12783849 (1)

    Genetic Association Database (GAD): IL1RAP
    Human Genome Epidemiology (HuGE) Navigator: IL1RAP (19 documents)

    Export disorders for IL1RAP gene to outside databases

    Publications
    for IL1RAP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1RAP gene, integrated from 9 sources (see all 168):
    (articles sorted by number of sources associating them with IL1RAP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping. (PubMed id 9479509)1, 2, 3, 9 Dale M.... Nicklin M.J.H. (1998)
    2. The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. (PubMed id 9862719)1, 2, 9 Lang D....Martin M.U. (1998)
    3. The interleukin-1 receptor accessory protein (IL-1RAc P) is essential for IL-1-induced activation of interleukin-1 receptor-associate d kinase (IRAK) and stress-activated protein kinases (SAP kinases). (PubMed id 9065432)1, 3, 9 Wesche H....Martin M.U. (1997)
    4. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. (PubMed id 9371760)1, 2, 9 Huang J.... Cao Z. (1997)
    5. IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. (PubMed id 10799889)1, 2, 9 Jensen L.E.... Whitehead A.S. (2000)
    6. Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis. (PubMed id 12781872)1, 2, 9 Jensen L.E. and Whitehead A.S. (2003)
    7. A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687. (PubMed id 17949817)1, 2, 9 Lu H.L.... Ting L.P. (2008)
    8. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. (PubMed id 12530978)1, 2, 9 Smith D.E.... Sims J.E. (2003)
    9. A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1. (PubMed id 19481478)1, 2 Smith D.E.... Sims J.E. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for IL1RAP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL1RAP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3556 HGNC: 5995 AceView: IL1RAP Ensembl:ENSG00000196083 euGenes: HUgn3556
    ECgene: IL1RAP Kegg: 3556 H-InvDB: IL1RAP

    Other Databases showing IL1RAP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL1RAP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1RAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL1RAP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IL1RAP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL1RAP gene:
    Search GeneIP for patents involving IL1RAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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