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Aliases for IL1RAP Gene

Aliases for IL1RAP Gene

  • Interleukin 1 Receptor Accessory Protein 2 3 5
  • IL-1 Receptor Accessory Protein 3 4
  • Interleukin-1 Receptor 3 3 4
  • IL-1RAcP 3 4
  • C3orf13 3 4
  • IL-1R3 3 4
  • IL1R3 3 4
  • Interleukin-1 Receptor Accessory Protein Beta 3
  • Interleukin-1 Receptor Accessory Protein 3
  • IL-1R-3 4

External Ids for IL1RAP Gene

Previous GeneCards Identifiers for IL1RAP Gene

  • GC03P187234
  • GC03P191494
  • GC03P191633
  • GC03P191552
  • GC03P191714
  • GC03P190231
  • GC03P187631

Summaries for IL1RAP Gene

Entrez Gene Summary for IL1RAP Gene

  • Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]

GeneCards Summary for IL1RAP Gene

IL1RAP (Interleukin 1 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL1RAP include Chromosome Xp21 Deletion Syndrome and Stromal Keratitis. Among its related pathways are Bacterial infections in CF airways and IL-1 signaling pathway. GO annotations related to this gene include signal transducer activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAPL2.

UniProtKB/Swiss-Prot for IL1RAP Gene

  • Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.

  • Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).

  • Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).

Gene Wiki entry for IL1RAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RAP Gene

Genomics for IL1RAP Gene

Regulatory Elements for IL1RAP Gene

Enhancers for IL1RAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G190616 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +103.7 103710 3.3 ELF3 PKNOX1 FOXA2 BMI1 YY1 TBX21 RFX3 CEBPA IKZF1 HNF4A IL1RAP GCNT1P3
GH03G190565 1.6 Ensembl ENCODE dbSUPER 11.4 +52.8 52822 3.1 FOXA2 MLX ARNT SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 IL1RAP GCNT1P3
GH03G190590 0.7 ENCODE 19.8 +77.5 77453 2.0 MAX RAD21 YY1 GATA3 HNF4G GATAD2A TEAD1 CEBPB MNT DPF2 IL1RAP GCNT1P3
GH03G190594 0.6 ENCODE dbSUPER 19.5 +81.1 81065 1.2 HNF4A IL1RAP GCNT1P3
GH03G190445 1.1 Ensembl ENCODE 10.2 -65.9 -65916 4.4 GTF2F1 TBP MXI1 JUN MAX FEZF1 BCL11B RFX5 ZKSCAN1 GATA4 IL1RAP CLDN16 TMEM207
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL1RAP on UCSC Golden Path with GeneCards custom track

Promoters for IL1RAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000163792 249 1801 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 ZNF207 FOS

Genomic Location for IL1RAP Gene

Chromosome:
3
Start:
190,514,051 bp from pter
End:
190,659,750 bp from pter
Size:
145,700 bases
Orientation:
Plus strand

Genomic View for IL1RAP Gene

Genes around IL1RAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RAP Gene

Proteins for IL1RAP Gene

  • Protein details for IL1RAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH3-IL1AP_HUMAN
    Recommended name:
    Interleukin-1 receptor accessory protein
    Protein Accession:
    Q9NPH3
    Secondary Accessions:
    • B1NLD0
    • D3DNW0
    • O14915
    • Q86WJ7

    Protein attributes for IL1RAP Gene

    Size:
    570 amino acids
    Molecular mass:
    65418 Da
    Quaternary structure:
    • The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Isoform 4 interacts with IL1R1 in a interleukin-1-dependent manner. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoechiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).

    Three dimensional structures from OCA and Proteopedia for IL1RAP Gene

    Alternative splice isoforms for IL1RAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1RAP Gene

Post-translational modifications for IL1RAP Gene

  • Glycosylation at posLast=5757, isoforms=2, 3, 5107, isoforms=2, 3, 5111, posLast=118118, posLast=196196, posLast=209209, and isoforms=2, 3, 5299
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IL1RAP (IL-1 RAcP/IL-1 R3)

No data available for DME Specific Peptides for IL1RAP Gene

Domains & Families for IL1RAP Gene

Suggested Antigen Peptide Sequences for IL1RAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPH3

UniProtKB/Swiss-Prot:

IL1AP_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RAP: view

Function for IL1RAP Gene

Molecular function for IL1RAP Gene

GENATLAS Biochemistry:
interleukin 1,receptor accessory protein,required for the recruitment of IRAK(1) to the interleukin 1 receptor complex,after induction by IL1A or IL1B
UniProtKB/Swiss-Prot Function:
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.
UniProtKB/Swiss-Prot Function:
Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).
UniProtKB/Swiss-Prot Induction:
Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment.

Gene Ontology (GO) - Molecular Function for IL1RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002114 interleukin-33 receptor activity IEA --
GO:0004871 signal transducer activity TAS 9065432
GO:0004908 interleukin-1 receptor activity IEA --
GO:1990782 protein tyrosine kinase binding IEA --
genes like me logo Genes that share ontologies with IL1RAP: view
genes like me logo Genes that share phenotypes with IL1RAP: view

Animal Models for IL1RAP Gene

MGI Knock Outs for IL1RAP:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RAP Gene

Localization for IL1RAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RAP Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1RAP gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IL1RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7775431
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with IL1RAP: view

Pathways & Interactions for IL1RAP Gene

genes like me logo Genes that share pathways with IL1RAP: view

SIGNOR curated interactions for IL1RAP Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL1RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006461 protein complex assembly TAS 7775431
GO:0006954 inflammatory response TAS,IEA --
GO:0006955 immune response TAS 9065432
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with IL1RAP: view

Drugs & Compounds for IL1RAP Gene

(4) Drugs for IL1RAP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL1RAP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL1RAP: view

Transcripts for IL1RAP Gene

Unigene Clusters for IL1RAP Gene

Interleukin 1 receptor accessory protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RAP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5:
SP6: - - - - - - -
SP7: - -
SP8: - - - - -
SP9: -
SP10:
SP11: -

Relevant External Links for IL1RAP Gene

GeneLoc Exon Structure for
IL1RAP
ECgene alternative splicing isoforms for
IL1RAP

Expression for IL1RAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL1RAP Gene

mRNA differential expression in normal tissues according to GTEx for IL1RAP Gene

This gene is overexpressed in Whole Blood (x10.3) and Liver (x8.4).

Protein differential expression in normal tissues from HIPED for IL1RAP Gene

This gene is overexpressed in Serum (57.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IL1RAP Gene



NURSA nuclear receptor signaling pathways regulating expression of IL1RAP Gene:

IL1RAP

SOURCE GeneReport for Unigene cluster for IL1RAP Gene:

Hs.478673

mRNA Expression by UniProt/SwissProt for IL1RAP Gene:

Q9NPH3-IL1AP_HUMAN
Tissue specificity: Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpresed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD).

Evidence on tissue expression from TISSUES for IL1RAP Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with IL1RAP: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RAP Gene

Orthologs for IL1RAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1RAP 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia IL1RAP 34 35
  • 90.64 (n)
cow
(Bos Taurus)
Mammalia IL1RAP 34 35
  • 87.43 (n)
mouse
(Mus musculus)
Mammalia Il1rap 34 16 35
  • 86.33 (n)
rat
(Rattus norvegicus)
Mammalia Il1rap 34
  • 85.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RAP 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1RAP 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1RAP 34 35
  • 69.76 (n)
lizard
(Anolis carolinensis)
Reptilia IL1RAP 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il1rap 34
  • 64.5 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01068246.1 35
  • 36 (a)
OneToOne
Species where no ortholog for IL1RAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RAP Gene

ENSEMBL:
Gene Tree for IL1RAP (if available)
TreeFam:
Gene Tree for IL1RAP (if available)

Paralogs for IL1RAP Gene

Paralogs for IL1RAP Gene

(2) SIMAP similar genes for IL1RAP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IL1RAP: view

Variants for IL1RAP Gene

Sequence variations from dbSNP and Humsavar for IL1RAP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000012012 -- 190,570,438(+) TGGTA(C/T)AGCTA intron-variant
rs1000049580 -- 190,519,288(+) TTTTA(G/T)TCCCT intron-variant
rs1000055429 -- 190,587,238(+) TCTGC(A/G)TTAGA intron-variant
rs1000085682 -- 190,606,263(+) ATAGT(A/G)GAAAG intron-variant
rs1000116308 -- 190,593,351(+) CTTGC(C/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RAP Gene

Variant ID Type Subtype PubMed ID
dgv131n6 CNV deletion 16902084
dgv2661n106 CNV deletion 24896259
esv1000745 CNV deletion 20482838
esv1433093 CNV deletion 17803354
esv1980229 CNV deletion 18987734
esv2440806 CNV deletion 19546169
esv2667728 CNV deletion 23128226
esv2677697 CNV deletion 23128226
esv2726382 CNV deletion 23290073
esv2726383 CNV deletion 23290073
esv3302996 CNV tandem duplication 20981092
esv34194 CNV loss 18971310
esv3563082 CNV deletion 23714750
esv3893843 CNV gain 25118596
esv4162 CNV loss 18987735
esv4944 CNV loss 18987735
esv6677 CNV gain 19470904
nsv1149600 CNV deletion 26484159
nsv829820 CNV gain 17160897
nsv956268 CNV deletion 24416366

Variation tolerance for IL1RAP Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1RAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1RAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RAP Gene

Disorders for IL1RAP Gene

MalaCards: The human disease database

(2) MalaCards diseases for IL1RAP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome xp21 deletion syndrome
  • complex glycerol kinase deficiency
stromal keratitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL1RAP

Genetic Association Database (GAD)
IL1RAP
Human Genome Epidemiology (HuGE) Navigator
IL1RAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1RAP
genes like me logo Genes that share disorders with IL1RAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RAP Gene

Publications for IL1RAP Gene

  1. The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping. (PMID: 9479509) Dale M. … Nicklin M.J.H. (Genomics 1998) 2 3 4 22 64
  2. A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687. (PMID: 17949817) Lu H.L. … Ting L.P. (Mol. Immunol. 2008) 3 4 22 64
  3. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. (PMID: 12530978) Smith D.E. … Sims J.E. (Immunity 2003) 3 4 22 64
  4. Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis. (PMID: 12781872) Jensen L.E. … Whitehead A.S. (Cell. Signal. 2003) 3 4 22 64
  5. IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. (PMID: 10799889) Jensen L.E. … Whitehead A.S. (J. Immunol. 2000) 3 4 22 64

Products for IL1RAP Gene

Sources for IL1RAP Gene

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