Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL1R2 Gene

Aliases for IL1R2 Gene

  • Interleukin 1 Receptor, Type II 2 3
  • IL1RB 3 4 6
  • CD121 Antigen-Like Family Member B 3 4
  • Interleukin-1 Receptor Type II 3 4
  • Interleukin-1 Receptor Beta 3 4
  • IL-1 Type II Receptor 3 4
  • IL-1R-Beta 3 4
  • IL-1RT-2 3 4
  • CDw121b 3 4
  • IL-1R-2 3 4
  • IL-1RT2 3 4
  • Interleukin 1 Receptor Type II Variant 3 3
  • Type II Interleukin-1 Receptor, Beta 3
  • Interleukin-1 Receptor Type 2 3
  • Antigen CDw121b 3
  • CD121b Antigen 4
  • CD121b 3
  • IL1R2c 3

External Ids for IL1R2 Gene

Previous HGNC Symbols for IL1R2 Gene

  • IL1RB

Previous GeneCards Identifiers for IL1R2 Gene

  • GC02P100479
  • GC02P101068
  • GC02P102212
  • GC02P102229
  • GC02P102066
  • GC02P101974
  • GC02P102608
  • GC02P096372

Summaries for IL1R2 Gene

Entrez Gene Summary for IL1R2 Gene

  • The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

GeneCards Summary for IL1R2 Gene

IL1R2 (Interleukin 1 Receptor, Type II) is a Protein Coding gene. Diseases associated with IL1R2 include joint disorders and aseptic meningitis. Among its related pathways are MAPK signaling pathway and NF-KappaB Family Pathway. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL1R2 Gene

  • Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Tocris Summary for IL1R2 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1R2 Gene

Genomics for IL1R2 Gene

Regulatory Elements for IL1R2 Gene

Genomic Location for IL1R2 Gene

Start:
101,991,820 bp from pter
End:
102,028,544 bp from pter
Size:
36,725 bases
Orientation:
Plus strand

Genomic View for IL1R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1R2 Gene

Proteins for IL1R2 Gene

  • Protein details for IL1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27930-IL1R2_HUMAN
    Recommended name:
    Interleukin-1 receptor type 2
    Protein Accession:
    P27930
    Secondary Accessions:
    • D3DVJ5
    • Q6LCE6
    • Q9UE68

    Protein attributes for IL1R2 Gene

    Size:
    398 amino acids
    Molecular mass:
    45421 Da
    Quaternary structure:
    • Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.

    Three dimensional structures from OCA and Proteopedia for IL1R2 Gene

    Alternative splice isoforms for IL1R2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1R2 Gene

Proteomics data for IL1R2 Gene at MOPED

Post-translational modifications for IL1R2 Gene

  • A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
  • Glycosylation at Asn66, Asn72, Asn112, Asn219, and Asn277
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1R2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL1R2 Gene

Domains for IL1R2 Gene

Gene Families for IL1R2 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for IL1R2 Gene

Graphical View of Domain Structure for InterPro Entry

P27930

UniProtKB/Swiss-Prot:

IL1R2_HUMAN :
  • P27930
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1R2: view

Function for IL1R2 Gene

Molecular function for IL1R2 Gene

GENATLAS Biochemistry:
interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble form
UniProtKB/Swiss-Prot Function:
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Gene Ontology (GO) - Molecular Function for IL1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity TAS 10191101
GO:0004910 interleukin-1, Type II, blocking receptor activity IEA --
GO:0005515 protein binding IPI 1830582
genes like me logo Genes that share ontologies with IL1R2: view

Animal Model Products

miRNA for IL1R2 Gene

miRTarBase miRNAs that target IL1R2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IL1R2 Gene

Localization for IL1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1R2 Gene

Isoform Short: Secreted.
Isoform Long: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1R2 Gene COMPARTMENTS Subcellular localization image for IL1R2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL1R2: view

Pathways for IL1R2 Gene

genes like me logo Genes that share pathways with IL1R2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 8898719
GO:0019221 cytokine-mediated signaling pathway TAS 10191101
genes like me logo Genes that share ontologies with IL1R2: view

Compounds for IL1R2 Gene

(4) Tocris Compounds for IL1R2 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist [185413-30-3]
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable [222018-18-0]
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction [1217448-66-2]
YM 90709 Interleukin-5 receptor antagonist [163769-88-8]

(1) Novoseek inferred chemical compound relationships for IL1R2 Gene

Compound -log(P) Hits PubMed IDs
dexamethasone 27.4 2
genes like me logo Genes that share compounds with IL1R2: view

Transcripts for IL1R2 Gene

Unigene Clusters for IL1R2 Gene

Interleukin 1 receptor, type II:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1R2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1R2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - -
SP2: -
SP3: - -
SP4: -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - -

Relevant External Links for IL1R2 Gene

GeneLoc Exon Structure for
IL1R2
ECgene alternative splicing isoforms for
IL1R2

Expression for IL1R2 Gene

mRNA expression in normal human tissues for IL1R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1R2 Gene

This gene is overexpressed in Whole Blood (45.0).

Protein differential expression in normal tissues for IL1R2 Gene

This gene is overexpressed in Serum (62.4) and Breast (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL1R2 Gene

SOURCE GeneReport for Unigene cluster for IL1R2 Gene Hs.25333

genes like me logo Genes that share expressions with IL1R2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL1R2 Gene

Orthologs for IL1R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL1R2 35
  • 79.22 (n)
  • 71.25 (a)
IL1R2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1R2 35
  • 81.92 (n)
  • 74.29 (a)
IL1R2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1r2 35
  • 70.71 (n)
  • 61.87 (a)
Il1r2 16
Il1r2 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1R2 35
  • 99.25 (n)
  • 99.25 (a)
IL1R2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1r2 35
  • 71.21 (n)
  • 62.63 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1R2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1R2 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1R2 35
  • 56.71 (n)
  • 44.27 (a)
IL1R2 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL1R2 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il1r2 35
  • 50.5 (n)
  • 39.52 (a)
Species with no ortholog for IL1R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1R2 Gene

ENSEMBL:
Gene Tree for IL1R2 (if available)
TreeFam:
Gene Tree for IL1R2 (if available)

Paralogs for IL1R2 Gene

Paralogs for IL1R2 Gene

Selected SIMAP similar genes for IL1R2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL1R2: view

Variants for IL1R2 Gene

Sequence variations from dbSNP and Humsavar for IL1R2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs719248 -- 102,007,413(-) AGAGA(A/G)TTTTC intron-variant
rs719249 -- 102,007,423(-) TTCAC(C/T)TGTCA intron-variant
rs719250 -- 102,007,256(-) ATGAA(A/G)CAGTC intron-variant
rs733498 -- 102,027,063(-) TTGGA(A/G)GAAAG intron-variant
rs757918 -- 101,996,837(-) TTGGC(A/G)TCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1R2 Gene

Variant ID Type Subtype PubMed ID
nsv874704 CNV Loss 21882294
nsv874705 CNV Loss 21882294
dgv4251n71 CNV Loss 21882294
dgv4252n71 CNV Loss 21882294
dgv4253n71 CNV Loss 21882294
esv2720456 CNV Deletion 23290073
esv2720457 CNV Deletion 23290073
esv2657953 CNV Deletion 23128226
esv2720458 CNV Deletion 23290073
esv2720459 CNV Deletion 23290073
nsv874715 CNV Loss 21882294
dgv4254n71 CNV Loss 21882294
nsv874717 CNV Gain 21882294
nsv874718 CNV Loss 21882294
dgv4255n71 CNV Loss 21882294
dgv4256n71 CNV Loss 21882294
dgv4257n71 CNV Loss 21882294
nsv874729 CNV Loss 21882294
nsv874731 CNV Loss 21882294

Relevant External Links for IL1R2 Gene

HapMap Linkage Disequilibrium report
IL1R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1R2 Gene

Disorders for IL1R2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IL1R2 Gene in MalaCards »

(2) Diseases for IL1R2 Gene including...

(1) University of Copenhagen DISEASES for IL1R2 Gene

(9) Novoseek inferred disease relationships for IL1R2 Gene

Disease -log(P) Hits PubMed IDs
endometriosis 60.9 21
polyarthritis 34.9 1
systemic inflammatory response syndrome 34.4 1
necrosis 32.2 7
inflammation 9.52 3

Relevant External Links for IL1R2

Genetic Association Database (GAD)
IL1R2
Human Genome Epidemiology (HuGE) Navigator
IL1R2
genes like me logo Genes that share disorders with IL1R2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IL1R2 Gene

Publications for IL1R2 Gene

  1. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 23
  2. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PMID: 1833184) McMahan C.J. … Sims J.E. (EMBO J. 1991) 2 3 4
  3. Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain. (PMID: 17919610) Akoum A. … Leboeuf M. (Fertil. Steril. 2008) 3 23
  4. Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist. (PMID: 7878046) Symons J.A. … Duff G.W. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4
  5. Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. (PMID: 7989776) Giri J.G. … Alderson M.R. (J. Immunol. 1994) 3 4

Products for IL1R2 Gene

Sources for IL1R2 Gene

Back to Top

Content