Aliases for IL1R2 Gene
Aliases for IL1R2 Gene
External Ids for IL1R2 Gene
- HGNC: 5994
- Entrez Gene: 7850
- Ensembl: ENSG00000115590
- OMIM: 147811
- UniProtKB: P27930
Previous HGNC Symbols for IL1R2 Gene
- IL1RB
Previous GeneCards Identifiers for IL1R2 Gene
- GC02P100479
- GC02P101068
- GC02P102212
- GC02P102229
- GC02P102066
- GC02P101974
- GC02P102608
- GC02P096372
Summaries for IL1R2 Gene
-
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
GeneCards Summary for IL1R2 Gene
IL1R2 (Interleukin 1 Receptor Type 2) is a Protein Coding gene. Diseases associated with IL1R2 include Endometriosis and Joint Disorders. Among its related pathways are Apoptosis Modulation and Signaling and IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1R1.
UniProtKB/Swiss-Prot for IL1R2 Gene
-
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for IL1R2 Gene
- Monarch Initiative
- Search for IL1R2 at DataMed
- Search for IL1R2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1R2 Gene
Genomics for IL1R2 Gene
GeneHancer (GH) Regulatory Elements for IL1R2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02I101991 | Promoter/Enhancer | 1.1 | EPDnew Ensembl | 550.8 | -0.2 | -172 | 0.9 | CTCF TRIM22 EBF1 ZNF48 POLR2A IKZF1 ZNF444 ZBTB33 IKZF2 SPI1 | IL1R2 LINC01127 GC02P101903 | |
GH02I102008 | Promoter | 0.6 | EPDnew | 550.4 | +16.7 | 16708 | 0.1 | L3MBTL2 | IL1R2 ENSG00000226925 IL1R1 GC02P101903 | |
GH02I101992 | Enhancer | 0.5 | Ensembl | 550.8 | +0.7 | 685 | 0.2 | ZNF202 POLR2A HDAC2 IKZF1 ZNF444 ZNF48 | IL1R2 IL1R1 GC02P101903 | |
GH02I101993 | Enhancer | 0.2 | Ensembl | 550.8 | +1.5 | 1485 | 0.2 | IL1R2 IL1R1 GC02P101903 | ||
GH02I101712 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 39.7 | -273.2 | -273181 | 11.9 | ZFP64 EBF1 BATF GATA3 ZNF316 EGR1 POLR2A ETV6 IKZF2 HOMEZ | IL1R2 RNF149 MAP4K4 IL1R1 GC02M101710 GC02P101903 |
Regulatory Element Products
Genomic Locations for IL1R2 Gene
- chr2:101,991,816-102,028,544
- (GRCh38/hg38)
- Size:
- 36,729 bases
- Orientation:
- Plus strand
- chr2:102,608,306-102,645,006
- (GRCh37/hg19)
Genomic View for IL1R2 Gene
- Cytogenetic band:
-
- 2q11.2 by Ensembl
- 2q11.2 by Entrez Gene
- 2q11.2 by HGNC


RefSeq DNA sequence for IL1R2 Gene
Proteins for IL1R2 Gene
-
Protein details for IL1R2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P27930-IL1R2_HUMAN
- Recommended name:
- Interleukin-1 receptor type 2
- Protein Accession:
- P27930
- D3DVJ5
- Q6LCE6
- Q9UE68
Protein attributes for IL1R2 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 45421 Da
- Quaternary structure:
-
- Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.
Protein Expression for IL1R2 Gene
Post-translational modifications for IL1R2 Gene
- A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
- Glycosylation at posLast=6666, posLast=7272, isoforms=2112, posLast=219219, and isoforms=2277
Other Protein References for IL1R2 Gene
Antibody Products
- R&D Systems Antibodies for IL1R2 (IL-1 RII)
-
Custom Antibody ServicesOriGene Antibodies for IL1R2
- Novus Biologicals Antibodies for IL1R2
-
Abcam antibodies for IL1R2
-
Cloud-Clone Corp. Antibodies for IL1R2
- Invitrogen Antibodies for IL1R2
- antibodies-online: Search results for 145 available IL1R2 Antibodies ranked by validation data
- Compare Top IL1R2 Antibodies
-
Recommended
- 1 CC Antibody (anti-rat)
- 8 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-mouse)
- 9 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-human)
- 2 EIA Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 76 WB Antibodies (anti-human)
- GeneTex IL1R2 antibody for IL1R2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL1R2
- Sino Biological Antibodies for IL1R2
Protein Products
- R&D Systems Proteins and Enzymes for IL1R2 (IL-1 RII)
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1R2
- Origene Custom Protein Services for IL1R2
- Sino Biological Recombinant Proteins for IL1R2
- Sino Biological Cell Lysates for IL1R2
-
Cloud-Clone Corp. Proteins for IL1R2
- Search GeneTex for Proteins for IL1R2
-
Abcam proteins for IL1R2
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for IL1R2
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for IL1R2 (IL-1 RII)
-
Cloud-Clone Corp. Assay Kits for IL1R2
- Sino Biological Assays for IL1R2
No data available for DME Specific Peptides for IL1R2 Gene
Domains & Families for IL1R2 Gene
Gene Families for IL1R2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL1R2 Gene
Suggested Antigen Peptide Sequences for IL1R2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P27930- Family:
-
- Belongs to the interleukin-1 receptor family.
Function for IL1R2 Gene
Molecular function for IL1R2 Gene
- GENATLAS Biochemistry:
- interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble form
- UniProtKB/Swiss-Prot Function:
- Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Phenotypes From GWAS Catalog for IL1R2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004908 | interleukin-1 receptor activity | TAS | 10191101 |
GO:0004910 | interleukin-1, Type II, blocking receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 1830582 |
GO:0019966 | interleukin-1 binding | IEA | -- |
Phenotypes for IL1R2 Gene
- MGI mutant phenotypes for IL1R2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IL1R2:
Animal Models for IL1R2 Gene
- MGI Knock Outs for IL1R2:
-
- Il1r2 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL1R2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IL1R2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL1R2 gene
- Search ViGene Biosciences for IL1R2
CRISPR Products
-
OriGene CRISPR knockouts for IL1R2
- genomics-online: gRNA clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
- Applied Biological Materials CRISPR for IL1R2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1R2
- GenScript: Design CRISPR guide RNA sequences for IL1R2
miRNA for IL1R2 Gene
- miRTarBase miRNAs that target IL1R2
miRNA Products
- Search ViGene Biosciences for IL1R2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IL1R2
- Browse OriGene Inhibitory RNA Products For IL1R2
- genomics-online: shRNA clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IL1R2 gene
Clone Products
- Sino Biological Human cDNA Clone for IL1R2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IL1R2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL1R2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IL1R2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL1R2 (IL-1 RII)
Cell Line Products
-
Horizon Cell Lines for IL1R2
-
ViGene Biosciences adenoviral particle packaged cDNA for IL1R2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IL1R2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL1R2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1R2 Gene
Localization for IL1R2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL1R2 Gene
- Isoform Short: Secreted.
- Isoform Long: Cell membrane; Single-pass type I membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1R2 Gene
Pathways & Interactions for IL1R2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK Pathway |
.36
|
|
2 | IL-2 Pathway |
.43
|
.36
|
3 | NF-KappaB Family Pathway | ||
4 | Cytokine Signaling in Immune system | ||
5 | IL-1 signaling pathway |
Pathways by source for IL1R2 Gene
3 BioSystems pathways for IL1R2 Gene
5 Reactome pathways for IL1R2 Gene
7 KEGG pathways for IL1R2 Gene
1 R&D Systems pathway for IL1R2 Gene
3 Tocris pathways for IL1R2 Gene
6 Qiagen pathways for IL1R2 Gene
Interacting Proteins for IL1R2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006955 | immune response | TAS | 8898719 |
GO:0010955 | negative regulation of protein processing | IEA | -- |
GO:0019221 | cytokine-mediated signaling pathway | IEA | -- |
GO:0050712 | negative regulation of interleukin-1 alpha secretion | IEA | -- |
GO:1900016 | negative regulation of cytokine production involved in inflammatory response | IEA | -- |
Drugs & Compounds for IL1R2 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Anakinra | Approved | Pharma | antagonist | IL-1 receptor antagonist | 0 | |
AF 12198 | Pharma | Type I IL-1 receptor antagonist, Potent, selective human type I IL-1 receptor antagonist | 0 | |||
YM 90709 | Pharma | Interleukin-5 receptor antagonist | 0 | |||
Ro 26-4550 trifluoroacetate | Pharma | reversible inhibitor of interleukin-2 (IL-2) binding to its receptor | 0 | |||
IL-1 | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Lyn peptide inhibitor |
|
222018-18-0 |
|
|
||
R 7050 |
|
303997-35-5 |
|
|
(5) Tocris Compounds for IL1R2 Gene
Compound | Action | Cas Number |
---|---|---|
AF 12198 | Potent, selective human type I IL-1 receptor antagonist | 185413-30-3 |
Lyn peptide inhibitor | Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable | 222018-18-0 |
R 7050 | Inhibitor of TNF-alpha receptor 1 signaling | 303997-35-5 |
Ro 26-4550 trifluoroacetate | Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction | 1217448-66-2 |
YM 90709 | Interleukin-5 receptor antagonist | 163769-88-8 |
(3) ApexBio Compounds for IL1R2 Gene
Compound | Action | Cas Number |
---|---|---|
AF 12198 | Type I IL-1 receptor antagonist | 185413-30-3 |
Ro 26-4550 trifluoroacetate | reversible inhibitor of interleukin-2 (IL-2) binding to its receptor | 1217448-66-2 |
YM 90709 | 163769-88-8 |
Transcripts for IL1R2 Gene
mRNA/cDNA for IL1R2 Gene
- (12) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (74) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IL1R2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IL1R2
- genomics-online: gRNA clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
- Applied Biological Materials CRISPR for IL1R2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1R2
- GenScript: Design CRISPR guide RNA sequences for IL1R2
miRNA Products
- Search ViGene Biosciences for IL1R2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IL1R2
- Browse OriGene Inhibitory RNA Products For IL1R2
- genomics-online: shRNA clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IL1R2 gene
Clone Products
- Sino Biological Human cDNA Clone for IL1R2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IL1R2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL1R2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IL1R2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL1R2 (IL-1 RII)
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - |
Expression for IL1R2 Gene
mRNA differential expression in normal tissues according to GTEx for IL1R2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1R2 Gene
NURSA nuclear receptor signaling pathways regulating expression of IL1R2 Gene:
IL1R2SOURCE GeneReport for Unigene cluster for IL1R2 Gene:
Hs.25333Evidence on tissue expression from TISSUES for IL1R2 Gene
- Blood(2.6)
- Spleen(2.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for IL1R2
-
OriGene qPCR primer pairs and template standards for IL1R2
- genomics-online: primer clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1R2 Gene
Orthologs for IL1R2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | IL1R2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | IL1R2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | IL1R2 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Il1r2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Il1r2 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | IL1R2 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | IL1R2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | IL1R2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | IL1R2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | il1r2 33 |
|
- Species where no ortholog for IL1R2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IL1R2 Gene
Variants for IL1R2 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000091265 | -- | 101,998,067(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000419466 | -- | 101,990,782(+) | C/A | upstream_transcript_variant | |
rs1000430549 | -- | 102,014,885(+) | CCC/CC | genic_upstream_transcript_variant, intron_variant | |
rs1000676586 | -- | 102,002,214(+) | C/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000692143 | -- | 101,996,333(+) | C/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6980n54 | CNV | loss | 21841781 |
esv2657953 | CNV | deletion | 23128226 |
esv2720456 | CNV | deletion | 23290073 |
esv2720457 | CNV | deletion | 23290073 |
esv2720458 | CNV | deletion | 23290073 |
esv2720459 | CNV | deletion | 23290073 |
esv3353381 | CNV | duplication | 20981092 |
esv3426758 | CNV | duplication | 20981092 |
nsv1132501 | CNV | duplication | 24896259 |
nsv1146528 | CNV | insertion | 26484159 |
nsv582551 | CNV | loss | 21841781 |
nsv582552 | CNV | loss | 21841781 |
Additional Variant Information for IL1R2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IL1R2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1R2 Gene
Disorders for IL1R2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
endometriosis |
|
|
joint disorders |
|
|
Additional Disease Information for IL1R2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IL1R2 Gene
Publications for IL1R2 Gene
- Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M … Nicklin MJ (Genomics 1999) 2 3 22 58
- A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PMID: 1833184) McMahan CJ … Brannan CI (The EMBO journal 1991) 2 3 4 58
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 44 58
- Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
Products for IL1R2 Gene
- R&D Systems Antibodies for IL1R2 (IL-1 RII)
- R&D Systems Proteins and Enzymes for IL1R2 (IL-1 RII)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for IL1R2 (IL-1 RII)
- R&D Systems cDNA Clones for IL1R2 (IL-1 RII)
- Browse Primary Antibodies
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- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
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- Custom Antibody ServicesOriGene Antibodies for IL1R2
- Custom Assay ServicesOriGene ELISA Kits for IL1R2
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1R2
- Origene Custom Protein Services for IL1R2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1R2
- Browse OriGene Inhibitory RNA Products For IL1R2
- OriGene qPCR primer pairs and template standards for IL1R2
- OriGene qPCR primer pairs for IL1R2
- OriGene CRISPR knockouts for IL1R2
- OriGene ORF clones in human for IL1R2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IL1R2
- GenScript: Next-day shipping of latest version cDNA ORF clones for IL1R2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IL1R2
- GenScript Custom Assay Services for IL1R2
- GenScript Custom overexpressing Cell Line Services for IL1R2
- GenScript: Design CRISPR guide RNA sequences for IL1R2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IL1R2
- Sino Biological Human cDNA Clone for IL1R2
- Sino Biological Cell Lysates for IL1R2
- Sino Biological Recombinant Proteins for IL1R2
- Sino Biological Antibodies for IL1R2
- Sino Biological Assays for IL1R2
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for IL1R2
- Novus Biologicals lysates and proteins for IL1R2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for IL1R2
- Abcam proteins for IL1R2
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for IL1R2
- Cloud-Clone Corp. Proteins for IL1R2
- Cloud-Clone Corp. Assay Kits for IL1R2
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for IL1R2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for IL1R2
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL1R2
- VectorBuilder custom plasmid, inducible vectors for IL1R2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL1R2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 145 available IL1R2 Antibodies ranked by validation data
- Compare Top IL1R2 Antibodies
- Recommended
- 76 WB Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 9 WB Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 8 WB Antibodies (anti-rat)
- 1 CC Antibody (anti-rat)
- antibodies-online: Search results for 39 available IL1R2 Elisa Kits ranked by validation data
- Compare Top IL1R2 Elisa Kits
- antibodies-online: Search results for 27 available IL1R2 Proteins ranked by validation data
- Compare Top IL1R2 Proteins
- GeneTex IL1R2 antibody for IL1R2
- Search GeneTex for Proteins for IL1R2
- ViGene Biosciences adenoviral particle packaged cDNA for IL1R2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IL1R2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for IL1R2 gene
- Search ViGene Biosciences for IL1R2
- Santa Cruz Biotechnology (SCBT) Antibodies for IL1R2
- Search Santa Cruz Biotechnology (SCBT) for IL1R2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL1R2
- Horizon Cell Lines for IL1R2
- genomics-online: cdna clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
- orf clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
- genomics-online: gRNA clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
- genomics-online: primer clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
- genomics-online: shRNA clones - Search results for 161 available IL1R2 gene related products
- Overview of 161 available IL1R2 gene related products
Sources for IL1R2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew