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IL1R2 Gene(Protein Coding)

Interleukin 1 Receptor Type 2

GCID:
GC02P101991
GIFtS:
55
Genes Participants
UDN Logo

Aliases for IL1R2 Gene

Aliases for IL1R2 Gene

  • Interleukin 1 Receptor Type 2 2 3 5
  • CD121 Antigen-Like Family Member B 3 4
  • Interleukin-1 Receptor Type II 3 4
  • Interleukin-1 Receptor Beta 3 4
  • IL-1 Type II Receptor 3 4
  • IL-1R-Beta 3 4
  • IL-1RT-2 3 4
  • CDw121b 3 4
  • IL-1R-2 3 4
  • IL-1RT2 3 4
  • IL1RB 3 4
  • Interleukin 1 Receptor Type II Variant 3 3
  • Type II Interleukin-1 Receptor, Beta 3
  • Interleukin 1 Receptor, Type II 2
  • Interleukin-1 Receptor Type 2 3
  • Antigen CDw121b 3
  • CD121b Antigen 4
  • CD121b 3
  • IL1R2c 3

External Ids for IL1R2 Gene

Previous HGNC Symbols for IL1R2 Gene

  • IL1RB

Previous GeneCards Identifiers for IL1R2 Gene

  • GC02P100479
  • GC02P101068
  • GC02P102212
  • GC02P102229
  • GC02P102066
  • GC02P101974
  • GC02P102608
  • GC02P096372

Summaries for IL1R2 Gene

Entrez Gene Summary for IL1R2 Gene

  • The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

GeneCards Summary for IL1R2 Gene

IL1R2 (Interleukin 1 Receptor Type 2) is a Protein Coding gene. Diseases associated with IL1R2 include Endometriosis and Joint Disorders. Among its related pathways are Apoptosis Modulation and Signaling and IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1R1.

UniProtKB/Swiss-Prot for IL1R2 Gene

  • Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Tocris Summary for IL1R2 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL1R2 Gene

Additional gene information for IL1R2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1R2 Gene

Genomics for IL1R2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IL1R2 Gene

Promoters and enhancers for IL1R2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I101991 Promoter/Enhancer 1.1 EPDnew Ensembl 550.8 -0.2 -172 0.9 CTCF TRIM22 EBF1 ZNF48 POLR2A IKZF1 ZNF444 ZBTB33 IKZF2 SPI1 IL1R2 LINC01127 GC02P101903
GH02I102008 Promoter 0.6 EPDnew 550.4 +16.7 16708 0.1 L3MBTL2 IL1R2 ENSG00000226925 IL1R1 GC02P101903
GH02I101992 Enhancer 0.5 Ensembl 550.8 +0.7 685 0.2 ZNF202 POLR2A HDAC2 IKZF1 ZNF444 ZNF48 IL1R2 IL1R1 GC02P101903
GH02I101993 Enhancer 0.2 Ensembl 550.8 +1.5 1485 0.2 IL1R2 IL1R1 GC02P101903
GH02I101712 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 39.7 -273.2 -273181 11.9 ZFP64 EBF1 BATF GATA3 ZNF316 EGR1 POLR2A ETV6 IKZF2 HOMEZ IL1R2 RNF149 MAP4K4 IL1R1 GC02M101710 GC02P101903
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL1R2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL1R2 gene promoter:

Genomic Locations for IL1R2 Gene

Genomic Locations for IL1R2 Gene
chr2:101,991,816-102,028,544
(GRCh38/hg38)
Size:
36,729 bases
Orientation:
Plus strand
chr2:102,608,306-102,645,006
(GRCh37/hg19)

Genomic View for IL1R2 Gene

Genes around IL1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1R2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL1R2 Gene

Proteins for IL1R2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IL1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27930-IL1R2_HUMAN
    Recommended name:
    Interleukin-1 receptor type 2
    Protein Accession:
    P27930
    Secondary Accessions:
    • D3DVJ5
    • Q6LCE6
    • Q9UE68

    Protein attributes for IL1R2 Gene

    Size:
    398 amino acids
    Molecular mass:
    45421 Da
    Quaternary structure:
    • Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.

    Three dimensional structures from OCA and Proteopedia for IL1R2 Gene

    Alternative splice isoforms for IL1R2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1R2 Gene

Protein Expression for IL1R2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL1R2 Gene

  • A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
  • Glycosylation at posLast=6666, posLast=7272, isoforms=2112, posLast=219219, and isoforms=2277

Other Protein References for IL1R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL1R2 Gene

Domains & Families for IL1R2 Gene

Gene Families for IL1R2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL1R2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IL1R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27930

UniProtKB/Swiss-Prot:

IL1R2_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1R2: view

Function for IL1R2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IL1R2 Gene

GENATLAS Biochemistry:
interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble form
UniProtKB/Swiss-Prot Function:
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Phenotypes From GWAS Catalog for IL1R2 Gene

Gene Ontology (GO) - Molecular Function for IL1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity TAS 10191101
GO:0004910 interleukin-1, Type II, blocking receptor activity IEA --
GO:0005515 protein binding IPI 1830582
GO:0019966 interleukin-1 binding IEA --
genes like me logo Genes that share ontologies with IL1R2: view
genes like me logo Genes that share phenotypes with IL1R2: view

Animal Models for IL1R2 Gene

MGI Knock Outs for IL1R2:

Animal Model Products

miRNA for IL1R2 Gene

miRTarBase miRNAs that target IL1R2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1R2 Gene

Localization for IL1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1R2 Gene

Isoform Short: Secreted.
Isoform Long: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1R2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL1R2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1R2 Gene

Pathways & Interactions for IL1R2 Gene

genes like me logo Genes that share pathways with IL1R2: view

SIGNOR curated interactions for IL1R2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for IL1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 8898719
GO:0010955 negative regulation of protein processing IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0050712 negative regulation of interleukin-1 alpha secretion IEA --
GO:1900016 negative regulation of cytokine production involved in inflammatory response IEA --
genes like me logo Genes that share ontologies with IL1R2: view

Drugs & Compounds for IL1R2 Gene

Products:

  1. Drug

(6) Drugs for IL1R2 Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anakinra Approved Pharma antagonist IL-1 receptor antagonist 0
AF 12198 Pharma Type I IL-1 receptor antagonist, Potent, selective human type I IL-1 receptor antagonist 0
YM 90709 Pharma Interleukin-5 receptor antagonist 0
Ro 26-4550 trifluoroacetate Pharma reversible inhibitor of interleukin-2 (IL-2) binding to its receptor 0
IL-1 Pharma 0

(3) Additional Compounds for IL1R2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lyn peptide inhibitor
222018-18-0
R 7050
303997-35-5

(5) Tocris Compounds for IL1R2 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8

(3) ApexBio Compounds for IL1R2 Gene

Compound Action Cas Number
AF 12198 Type I IL-1 receptor antagonist 185413-30-3
Ro 26-4550 trifluoroacetate reversible inhibitor of interleukin-2 (IL-2) binding to its receptor 1217448-66-2
YM 90709 163769-88-8
genes like me logo Genes that share compounds with IL1R2: view

Drug Products

Transcripts for IL1R2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL1R2 Gene

(12) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1R2 Gene

Interleukin 1 receptor, type II:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1R2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - -
SP2: -
SP3: - -
SP4: -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - -

Relevant External Links for IL1R2 Gene

GeneLoc Exon Structure for
IL1R2
ECgene alternative splicing isoforms for
IL1R2

Expression for IL1R2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL1R2 Gene

mRNA expression in normal human tissues for IL1R2 Gene
mRNA expression by BioGPS for IL1R2 GenemRNA expression by GTEx for IL1R2 Gene

mRNA differential expression in normal tissues according to GTEx for IL1R2 Gene

This gene is overexpressed in Whole Blood (x45.0).

Protein differential expression in normal tissues from HIPED for IL1R2 Gene

This gene is overexpressed in Serum (62.4) and Breast (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1R2 Gene



Protein tissue co-expression partners for IL1R2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL1R2 Gene:

IL1R2

SOURCE GeneReport for Unigene cluster for IL1R2 Gene:

Hs.25333

Evidence on tissue expression from TISSUES for IL1R2 Gene

  • Blood(2.6)
  • Spleen(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with IL1R2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1R2 Gene

Orthologs for IL1R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IL1R2 33 34
  • 99.25 (n)
dog
(Canis familiaris)
 Mammalia IL1R2 33 34
  • 81.92 (n)
cow
(Bos Taurus)
 Mammalia IL1R2 33 34
  • 79.22 (n)
rat
(Rattus norvegicus)
 Mammalia Il1r2 33
  • 71.21 (n)
mouse
(Mus musculus)
 Mammalia Il1r2 33 16 34
  • 70.71 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia IL1R2 34
  • 50 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia IL1R2 34
  • 45 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves IL1R2 33 34
  • 56.71 (n)
lizard
(Anolis carolinensis)
 Reptilia IL1R2 34
  • 40 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia il1r2 33
  • 50.5 (n)
Species where no ortholog for IL1R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1R2 Gene

ENSEMBL:
Gene Tree for IL1R2 (if available)
TreeFam:
Gene Tree for IL1R2 (if available)

Paralogs for IL1R2 Gene

Paralogs for IL1R2 Gene

(1) SIMAP similar genes for IL1R2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL1R2: view

Variants for IL1R2 Gene

Sequence variations from dbSNP and Humsavar for IL1R2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000091265 -- 101,998,067(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000419466 -- 101,990,782(+) C/A upstream_transcript_variant
rs1000430549 -- 102,014,885(+) CCC/CC genic_upstream_transcript_variant, intron_variant
rs1000676586 -- 102,002,214(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000692143 -- 101,996,333(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL1R2 Gene

Variant ID Type Subtype PubMed ID
dgv6980n54 CNV loss 21841781
esv2657953 CNV deletion 23128226
esv2720456 CNV deletion 23290073
esv2720457 CNV deletion 23290073
esv2720458 CNV deletion 23290073
esv2720459 CNV deletion 23290073
esv3353381 CNV duplication 20981092
esv3426758 CNV duplication 20981092
nsv1132501 CNV duplication 24896259
nsv1146528 CNV insertion 26484159
nsv582551 CNV loss 21841781
nsv582552 CNV loss 21841781

Variation tolerance for IL1R2 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL1R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1R2 Gene

Disorders for IL1R2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IL1R2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometriosis
joint disorders
  • arthropathy
- elite association - COSMIC cancer census association via MalaCards
Search IL1R2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL1R2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1R2 Gene

Publications for IL1R2 Gene

  1. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M … Nicklin MJ (Genomics 1999) 2 3 22 58
  2. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PMID: 1833184) McMahan CJ … Brannan CI (The EMBO journal 1991) 2 3 4 58
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 44 58
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

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Sources for IL1R2 Gene

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