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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1R2 Gene

protein-coding   GIFtS: 62
GCID: GC02P102608

interleukin 1 receptor, type II


(Previous symbol: IL1RB)
 Explore 37 diseases affiliated with
IL1R2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL1R2    

Aliases
for IL1R2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 1 Receptor, Type II1 2     IL-1RT22 3
IL1RB1 2 3 5     CD121 Antigen-Like Family Member B2 3
CD121b1 2     IL-1 Type II Receptor2 3
Interleukin-1 Receptor Beta2 3     IL1R2c2
Interleukin-1 Receptor Type II2 3     Antigen CDw121b2
CDw121b2 3     Interleukin 1 Receptor Type II Variant 32
IL-1R-22 3     Interleukin-1 Receptor Type 22
IL-1R-Beta1     Type II Interleukin-1 Receptor, Beta2
IL-1RT-22 3     CD121b Antigen3

External Ids:    HGNC: 59941   Entrez Gene: 78502   Ensembl: ENSG000001155907   OMIM: 1478115   UniProtKB: P279303   

Export aliases for IL1R2 gene to outside databases

Previous GC identifers: GC02P100479 GC02P101068 GC02P102212 GC02P102229 GC02P102066 GC02P101974 GC02P096372


Summaries
for IL1R2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL1R2:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein
binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as
a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity
of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a
cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and
protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also
produced by proteolytic cleavage. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930
Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by
competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through
non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds
IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation
may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

summary for IL1R2:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R2 (Interleukin 1 receptor, type II)


Genomic Views
for IL1R2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1R2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12

IL1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1R2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102608:  view genomic region     (about GC identifiers)

Start:
 102,608,306 bp from pter      End:
 102,645,006 bp from pter
Size:
 36,701 bases      Orientation:
 plus strand

Proteins
for IL1R2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930 (See protein sequence)
Recommended Name: Interleukin-1 receptor type 2 precursor  
Size: 398 amino acids; 45421 Da
Subunit: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex
Subcellular location: Isoform Short: Secreted
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for IL1R2:
3O4O (3D)    
Secondary accessions: D3DVJ5 Q6LCE6 Q9UE68
Alternative splicing: 2 isoforms:  P27930-1   P27930-2   

Explore the universe of human proteins at neXtProt for IL1R2: NX_P27930

Post-translational modifications:

  • A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a
    • metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P27930

    • IL1R2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001248348.1  NP_004624.1  

    ENSEMBL proteins: 
     ENSP00000330959   ENSP00000377066   ENSP00000408415   ENSP00000414611  
    Reactome Protein details: P27930
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): IL1R2
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    Novus Biologicals IL1R2 Proteins
    Novus Biologicals IL1R2 Lysates
    Sino Biological Recombinant Protein for IL1R2
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IL1R2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    IL1R2 for ontologies           About GeneDecksing



    IL1R2 Antibody Products: 
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    Uscn Antibodies for IL1R2
    ThermoFisher Antibody for IL1R2

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    Uscn ELISAs and CLIAs for IL1R2

    Protein Domains /
    Families
    for IL1R2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL1R2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR015621 IL1-receptor_fam
     IPR007110 Ig-like_dom
     IPR004077 Interleukin-1_rcpt_II
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P27930

    ProtoNet protein and cluster: P27930

    3 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004077 Interleukin-1 receptor type II precursor signature


    UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for IL1R2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930
    Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by
    competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through
    non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds
    IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation
    may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

         Genatlas biochemistry entry for IL1R2:
    interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble form

    miRNA
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for IL1R2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1R2 

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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004908interleukin-1 receptor activity TAS10191101
    GO:0004910interleukin-1, Type II, blocking receptor activity IEA--
    GO:0005515protein binding IPI1830582


    IL1R2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for IL1R2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Toll-like Receptor Pathway
    		Toll-like Receptor Pathway1.00
    		MAPK Pathway0.36
    2Interleukin-1 signaling
    		Interleukin-1 signaling1.00
    		IL1-mediated signaling events0.39
    3NF-KappaB Family Pathway
    		NF-KappaB Family Pathway1.00
    		NF-KappaB (p50-p65) Pathway0.72
    4MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    5ErbB4 Pathway
    		TREM1 Pathway0.32
    		HMGB1 Pathway0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL1R2 (see all 6)
        MAPK Signaling
    NF-KappaB (p50-p65) Pathway
    HMGB1 Pathway
    TREM1 Pathway
    p38 Signaling

    3 Tocris Bioscience Pathways for IL1R2
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    4 BioSystems Pathways for IL1R2 
        MAPK signaling pathway
    IL-1 Signaling Pathway
    Apoptosis Modulation and Signaling
    IL1-mediated signaling events

    4        Reactome Pathways for IL1R2
        Interleukin-1 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    4         Kegg Pathways  (Kegg details for IL1R2):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
    Amoebiasis


    IL1R2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for IL1R2 (P279303 ENSP000003309594) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1RNP185103, ENSP000002592064I2D: score=4 STRING: ENSP00000259206
    IL1AP015833, ENSP000002633394I2D: score=3 STRING: ENSP00000263339
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=3 STRING: ENSP00000072516
    IL1BP015843, ENSP000002633414I2D: score=3 STRING: ENSP00000263341
    IL1R1ENSP000002339464STRING: ENSP00000233946
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS8898719


    IL1R2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL1R2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL1R2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for IL1R2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AF 12198 Potent, selective human type I IL-1 receptor antagonist [185413-30-3]
    1 Novoseek chemical compound relationship for IL1R2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 27.4 2 10085100 (1), 18346142 (1)

    Search CenterWatch for drugs/clinical trials and news about IL1R2 

    Transcripts
    for IL1R2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL1R2 gene (3 alternative transcripts): 
    NM_001261419.1  NM_004633.3  NM_173343.1  

    Unigene Cluster for IL1R2:

    Interleukin 1 receptor, type II
    Hs.25333  [show with all ESTs]
    Unigene Representative Sequence: NM_004633
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332549(uc002tbm.3) ENST00000464994 ENST00000493749 ENST00000393414(uc002tbn.3)
    ENST00000457817 ENST00000441002(uc002tbo.1) ENST00000482658 ENST00000474085
    ENST00000485335

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK130412.1 AK309161.1 BC012346.1 BC027733.2 BC039031.1 NR_048564.1 U64094.1 U74649.1 
    X59770.1 

    5 DOTS entries:

    DT.452355  DT.100749512  DT.95271208  DT.91674537  DT.95271209 

    24/74 AceView cDNA sequences (see all 74):

    U64094 BC027733 BQ685045 BU631559 BQ084106 CB157192 NM_004633 BX113594 
    AW196698 AK130412 NM_173343 BX343679 BM973329 CA306304 CA415786 AW236977 
    AI867567 X59770 AU099372 BC039031 CA448938 BC012346 BQ688121 CR616861 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IL1R2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                    -     -     -     -                             -                                         -               
    SP2:                                                                    -                                                         
    SP3:                                      -                             -                                                         
    SP4:                                                                    -                                                         
    SP5:                    -     -     -     -           -                 -                                                         


    ECgene alternative splicing isoforms for IL1R2

    Expression
    for IL1R2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGCCAGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL1R2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungTracheaBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL1R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL1R2

    SOURCE GeneReport for Unigene cluster: Hs.25333
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL1R2 (see all 6): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Atherosclerosis in human mouse rat
              T Helper Cell Differentiation in human mouse rat

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    In Situ
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    Orthologs
    for IL1R2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL1R2 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IL1R21 interleukin 1 receptor, type II 57.29(n)
    45.08(a)    		   418715  XM_416914.3  XP_416914.2 
    lizard
    (Anolis carolinensis)    		 Reptilia IL1R26
    		 --
    		 40(a)
    		 1 ↔ 1
    		 GL343243.1(1782367-1797806)


    ENSEMBL Gene Tree for IL1R2 (if available)
    TreeFam Gene Tree for IL1R2 (if available) 

    Paralogs
    for IL1R2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL1R2 gene
    IL1RAPL22  IL1RL22  IL1RAP2  IL1RAPL12  IL18RAP2  IL18R12  SIGIRR2  IL1RL12  
    IL1R12  
    1 SIMAP similar gene for IL1R2 using alignment to 3 protein entries:     IL1R2_HUMAN (see all proteins):
    IL1R1

    IL1R2 for paralogs           About GeneDecksing



    Genomic Variants
    for IL1R2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/899 NCBI SNPs in IL1R2 are shown (see all 899)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs67267131,2
    		C,F,A,H,--102606463(+) GGACAC/TAGTGC 2 -- us2k19Minor allele frequency- T:0.11NS EA NA WA 1208
    rs1826066131,2
    		--102606486(+) GAAGCA/GGGGCG 2 -- us2k10--------
    rs1122726721,2
    		--102606490(+) CGGGGC/TGGAGG 2 -- us2k10--------
    rs41411341,2
    		C,F,A,H,--102606526(-) CCTGCT/CGGAGC 2 -- us2k130Minor allele frequency- C:0.18NS EA NA WA CSA 2773
    rs1163056481,2
    		F,--102606592(+) CTATGT/GAAGCA 2 -- us2k11Minor allele frequency- G:0.07WA 118
    rs772781381,2
    		F,--102606595(+) TGTAAG/ACAATT 2 -- us2k11Minor allele frequency- A:0.19WA 118
    rs170263631,2
    		C,F,H,--102606656(+) AATTCC/TTCCTT 2 -- us2k1 tfbs39Minor allele frequency- T:0.01NA NS EA WA 680
    rs67416151,2
    		C,F,A,H,--102606671(+) ATCACA/CAGATC 2 -- us2k15Minor allele frequency- C:0.05NS EA WA 536
    rs729885441,2
    		C,--102606701(+) GCCAAG/CAGCAG 2 -- us2k12Minor allele frequency- C:0.04WA 120
    rs766361661,2
    		F,--102606817(+) TTTAGT/GTGAGC 2 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for IL1R2 (102608306 - 102645006 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL1R2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL1R2
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1R2

    Disorders / Diseases
    for IL1R2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL1R2 for disorders           About GeneDecksing

    OMIM gene information: 147811    OMIM disorders: --

    20/37 diseases for IL1R2 (see all 37):    About MalaCards
    patent ductus arteriosus    dengue hemorrhagic fever    hemorrhagic fever    ankylosing spondylitis
    chronic fatigue syndrome    joint disorders    rheumatoid arthritis    ascariasis
    trichuriasis    spondylitis    bronchiolitis    mastitis
    multiple myeloma    alzheimer's disease    endometriosis    periodontitis
    periodontal disease    sepsis    hepatitis b    acute pancreatitis

    1 disease from the University of Copenhagen DISEASES database for IL1R2:
    Endometriosis

    9 Novoseek disease relationships for IL1R2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometriosis 60.9 27 17709570 (4), 17517439 (4), 17919610 (4), 17482186 (2) (see all 10)
    polyarthritis 34.9 1 14586853 (1)
    systemic inflammatory response syndrome 34.4 1 8605344 (1)
    necrosis 32.2 10 15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 7)
    inflammation 9.52 3 9627018 (1), 7680670 (1), 17138054 (1)
    alzheimers disease 8.8 2 10216202 (1), 15843049 (1)
    rheumatoid arthritis 3.63 1 18780536 (1)
    sepsis 0 2 7680670 (2)
    tumors 0 9 15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 6)

    Genetic Association Database (GAD): IL1R2
    Human Genome Epidemiology (HuGE) Navigator: IL1R2 (34 documents)

    Export disorders for IL1R2 gene to outside databases

    Publications
    for IL1R2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1R2 gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with IL1R2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PubMed id 1833184)1, 2, 3 McMahan C.J....Brannan C.I. (1991)
    2. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)1, 3, 9 Dale M. and Nicklin M.J. (1999)
    3. Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients. (PubMed id 15653174)1, 4 Seripa D....Fazio V.M. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. (PubMed id 12530978)1, 2 Smith D.E.... Sims J.E. (2003)
    7. Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes. (PubMed id 12363051)1, 4 Loke H....Hill A. (2002)
    8. Smoking and polymorphisms of the interleukin-1 gene cluster (IL-1alpha, IL-1beta, and IL-1RN) in patients with periodontal disease. (PubMed id 11846196)1, 4 Meisel P....Kocher T. (2002)
    9. The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. (PubMed id 9862719)1, 2 Lang D....Martin M.U. (1998)
    10. Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. (PubMed id 8702856)1, 2 Liu C.... Souza E.B. (1996)

    External Searches for IL1R2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL1R2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7850 HGNC: 5994 AceView: IL1R2 Ensembl:ENSG00000115590 euGenes: HUgn7850
    ECgene: IL1R2 Kegg: 7850 H-InvDB: IL1R2

    Other Databases showing IL1R2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL1R2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1R2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il1r2/

    Intellectual Property
    for IL1R2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL1R2 gene:
    Search GeneIP for patents involving IL1R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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