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IL1R2 Gene(Protein Coding)

Interleukin 1 Receptor Type 2

GCID:
GC02P101991
GIFtS:
63
Genes Participants
UDN Logo

Aliases for IL1R2 Gene

Aliases for IL1R2 Gene

  • Interleukin 1 Receptor Type 2 2 3
  • Interleukin 1 Receptor, Type II 2 3 5
  • CD121 Antigen-Like Family Member B 3 4
  • Interleukin-1 Receptor Type II 3 4
  • Interleukin-1 Receptor Beta 3 4
  • IL-1 Type II Receptor 3 4
  • IL-1R-Beta 3 4
  • IL-1RT-2 3 4
  • CDw121b 3 4
  • IL-1R-2 3 4
  • IL-1RT2 3 4
  • IL1RB 3 4
  • Interleukin 1 Receptor Type II Variant 3 3
  • Type II Interleukin-1 Receptor, Beta 3
  • Antigen CDw121b 3
  • CD121b Antigen 4
  • CD121b 3
  • IL1R2c 3

External Ids for IL1R2 Gene

Previous HGNC Symbols for IL1R2 Gene

  • IL1RB

Previous GeneCards Identifiers for IL1R2 Gene

  • GC02P100479
  • GC02P101068
  • GC02P102212
  • GC02P102229
  • GC02P102066
  • GC02P101974
  • GC02P102608
  • GC02P096372

Summaries for IL1R2 Gene

Entrez Gene Summary for IL1R2 Gene

  • The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

GeneCards Summary for IL1R2 Gene

IL1R2 (Interleukin 1 Receptor Type 2) is a Protein Coding gene. Diseases associated with IL1R2 include Endometriosis and Rheumatoid Arthritis. Among its related pathways are HTLV-I infection and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL1R2 Gene

  • Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Tocris Summary for IL1R2 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL1R2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1R2 Gene

Genomics for IL1R2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for IL1R2 Gene

Enhancers for IL1R2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL1R2 on UCSC Golden Path with GeneCards custom track

Promoters for IL1R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL1R2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL1R2 gene promoter:

Genomic Location for IL1R2 Gene

Chromosome:
2
Start:
101,991,816 bp from pter
End:
102,028,544 bp from pter
Size:
36,729 bases
Orientation:
Plus strand

Genomic View for IL1R2 Gene

Genes around IL1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1R2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL1R2 Gene

Proteins for IL1R2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IL1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27930-IL1R2_HUMAN
    Recommended name:
    Interleukin-1 receptor type 2
    Protein Accession:
    P27930
    Secondary Accessions:
    • D3DVJ5
    • Q6LCE6
    • Q9UE68

    Protein attributes for IL1R2 Gene

    Size:
    398 amino acids
    Molecular mass:
    45421 Da
    Quaternary structure:
    • Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.

    Three dimensional structures from OCA and Proteopedia for IL1R2 Gene

    Alternative splice isoforms for IL1R2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1R2 Gene

Proteomics data for IL1R2 Gene at MOPED

Protein Expression for IL1R2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL1R2 Gene

  • A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
  • Glycosylation at Asn 66, Asn 72, Asn 112, Asn 219, and Asn 277
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL1R2 Gene

Domains & Families for IL1R2 Gene

Gene Families for IL1R2 Gene

HGNC:
IUPHAR :

Protein Domains for IL1R2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IL1R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27930

UniProtKB/Swiss-Prot:

IL1R2_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1R2: view

Function for IL1R2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for IL1R2 Gene

GENATLAS Biochemistry:
interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble form
UniProtKB/Swiss-Prot Function:
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Phenotypes for IL1R2 Gene

GenomeRNAi human phenotypes for IL1R2:
genes like me logo Genes that share phenotypes with IL1R2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL1R2

miRNA for IL1R2 Gene

miRTarBase miRNAs that target IL1R2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL1R2 Gene

Localization for IL1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1R2 Gene

Isoform Short: Secreted.
Isoform Long: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1R2 Gene COMPARTMENTS Subcellular localization image for IL1R2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 3
nucleus 3
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IL1R2 Gene

Pathways & Interactions for IL1R2 Gene

genes like me logo Genes that share pathways with IL1R2: view

SIGNOR curated interactions for IL1R2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for IL1R2 Gene

None

Drugs & Compounds for IL1R2 Gene

Products:

  1. Drug

(3) Drugs for IL1R2 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anakinra Approved Pharma antagonist IL-1 receptor antagonist 0
IL-1 Pharma 0

(5) Additional Compounds for IL1R2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AF 12198
185413-30-3
Lyn peptide inhibitor
222018-18-0
R 7050
303997-35-5
Ro 26-4550 trifluoroacetate
1217448-66-2
YM 90709
163769-88-8

(5) Tocris Compounds for IL1R2 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8
genes like me logo Genes that share compounds with IL1R2: view

Transcripts for IL1R2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for IL1R2 Gene

(13) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1R2 Gene

Interleukin 1 receptor, type II:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1R2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - -
SP2: -
SP3: - -
SP4: -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - -

Relevant External Links for IL1R2 Gene

GeneLoc Exon Structure for
IL1R2
ECgene alternative splicing isoforms for
IL1R2

Expression for IL1R2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for IL1R2 Gene

mRNA expression in normal human tissues for IL1R2 Gene
mRNA expression by BioGPS for IL1R2 GenemRNA expression by GTEx for IL1R2 Gene

mRNA differential expression in normal tissues according to GTEx for IL1R2 Gene

This gene is overexpressed in Whole Blood (x45.0).

Protein differential expression in normal tissues from HIPED for IL1R2 Gene

This gene is overexpressed in Serum (62.4) and Breast (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1R2 Gene



SOURCE GeneReport for Unigene cluster for IL1R2 Gene Hs.25333

genes like me logo Genes that share expression patterns with IL1R2: view

Protein tissue co-expression partners for IL1R2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IL1R2 Gene

Orthologs for IL1R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia IL1R2 35
  • 79.22 (n)
  • 71.25 (a)
IL1R2 36
  • 70 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia IL1R2 35
  • 81.92 (n)
  • 74.29 (a)
IL1R2 36
  • 69 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Il1r2 35
  • 70.71 (n)
  • 61.87 (a)
Il1r2 16
Il1r2 36
  • 60 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia IL1R2 35
  • 99.25 (n)
  • 99.25 (a)
IL1R2 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Il1r2 35
  • 71.21 (n)
  • 62.63 (a)
oppossum
(Monodelphis domestica)
 Mammalia IL1R2 36
  • 45 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IL1R2 36
  • 50 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves IL1R2 35
  • 56.71 (n)
  • 44.27 (a)
IL1R2 36
  • 42 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia IL1R2 36
  • 40 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia il1r2 35
  • 50.5 (n)
  • 39.52 (a)
Species with no ortholog for IL1R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1R2 Gene

ENSEMBL:
Gene Tree for IL1R2 (if available)
TreeFam:
Gene Tree for IL1R2 (if available)

Paralogs for IL1R2 Gene

Paralogs for IL1R2 Gene

(1) SIMAP similar genes for IL1R2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL1R2: view

Variants for IL1R2 Gene

Sequence variations from dbSNP and Humsavar for IL1R2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs28385682 - 102,019,665(+) ACAAT(A/G)AGAAA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs3218976 - 102,024,655(+) TGACC(A/G/T)AGGGG nc-transcript-variant, reference, missense
rs719248 -- 102,007,413(-) AGAGA(A/G)TTTTC intron-variant
rs719249 -- 102,007,423(-) TTCAC(C/T)TGTCA intron-variant
rs719250 -- 102,007,256(-) ATGAA(A/G)CAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1R2 Gene

Variant ID Type Subtype PubMed ID
nsv874704 CNV Loss 21882294
nsv874705 CNV Loss 21882294
dgv4251n71 CNV Loss 21882294
dgv4252n71 CNV Loss 21882294
dgv4253n71 CNV Loss 21882294
esv2720456 CNV Deletion 23290073
esv2720457 CNV Deletion 23290073
esv2657953 CNV Deletion 23128226
esv2720458 CNV Deletion 23290073
esv2720459 CNV Deletion 23290073
nsv874715 CNV Loss 21882294
dgv4254n71 CNV Loss 21882294
nsv874717 CNV Gain 21882294
nsv874718 CNV Loss 21882294
dgv4255n71 CNV Loss 21882294
dgv4256n71 CNV Loss 21882294
dgv4257n71 CNV Loss 21882294
nsv874729 CNV Loss 21882294
nsv874731 CNV Loss 21882294

Variation tolerance for IL1R2 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL1R2 Gene

Disorders for IL1R2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IL1R2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometriosis
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search IL1R2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL1R2

Genetic Association Database (GAD)
IL1R2
Human Genome Epidemiology (HuGE) Navigator
IL1R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1R2
genes like me logo Genes that share disorders with IL1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1R2 Gene

Publications for IL1R2 Gene

  1. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PMID: 1833184) McMahan C.J. … Sims J.E. (EMBO J. 1991) 2 3 4 67
  2. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 23
  3. Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway. (PMID: 19026558) Chang S.Y. … Lee T.C. (Cytokine 2009) 3 23
  4. Alternate splicing of interleukin-1 receptor type II (IL1R2) in vitro correlates with clinical glucocorticoid responsiveness in patients with AIED. (PMID: 19401759) Vambutas A. … Bonagura V. (PLoS ONE 2009) 3 23
  5. Role of interleukin-1 receptor type II in the pathogenesis of endometriosis. (PMID: 17482186) Hou Z. … Liu J. (Fertil. Steril. 2008) 3 23

Products for IL1R2 Gene

Sources for IL1R2 Gene

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