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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1R2 Gene

protein-coding   GIFtS: 64
GCID: GC02P102608

Interleukin 1 Receptor, Type II


(Previous symbol: IL1RB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 1 Receptor, Type II1 2     CD121 Antigen-Like Family Member B2 3
IL1RB1 2 3 5     IL-1 Type II Receptor2 3
Interleukin-1 Receptor Beta2 3     CD121b2
Interleukin-1 Receptor Type II2 3     IL1R2c2
CDw121b2 3     Antigen CDw121b2
IL-1R-22 3     Interleukin 1 Receptor Type II Variant 32
IL-1R-beta2 3     Interleukin-1 Receptor Type 22
IL-1RT-22 3     Type II Interleukin-1 Receptor, Beta2
IL-1RT22 3     CD121b Antigen3

External Ids:    HGNC: 59941   Entrez Gene: 78502   Ensembl: ENSG000001155907   OMIM: 1478115   UniProtKB: P279303   

Export aliases for IL1R2 gene to outside databases

Previous GC identifers: GC02P100479 GC02P101068 GC02P102212 GC02P102229 GC02P102066 GC02P101974 GC02P096372


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1R2 Gene:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This
protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA),
and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to
antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and
three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in
multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble
proteins. A soluble protein is also produced by proteolytic cleavage. (provided by RefSeq, May 2012)

GeneCards Summary for IL1R2 Gene: 
IL1R2 (interleukin 1 receptor, type II) is a protein-coding gene. Diseases associated with IL1R2 include joint disorders, and ascariasis, and among its related super-pathways are MAPK signaling pathway and IL1-mediated signaling events. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RL2.

UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930
Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by
competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through
non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially
binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this
complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

summary for IL1R2 Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R2 (Interleukin 1 receptor, type II) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1R2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1R2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12

IL1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1R2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102608:  view genomic region     (about GC identifiers)

Start:
102,608,306 bp from pter      End:
102,645,006 bp from pter
Size:
36,701 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930 (See protein sequence)
Recommended Name: Interleukin-1 receptor type 2 precursor  
Size: 398 amino acids; 45421 Da
Subunit: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex
Subcellular location: Isoform Short: Secreted
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for IL1R2:
3O4O (3D)    
Secondary accessions: D3DVJ5 Q6LCE6 Q9UE68
Alternative splicing: 2 isoforms:  P27930-1   P27930-2   

Explore the universe of human proteins at neXtProt for IL1R2: NX_P27930

Explore proteomics data for IL1R2 at MOPED 

Post-translational modifications:

  • UniProtKB: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a
    metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27930

  • IL1R2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL1R2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001248348.1  NP_004624.1  

    ENSEMBL proteins: 
     ENSP00000330959   ENSP00000377066   ENSP00000408415   ENSP00000414611  
    Reactome Protein details: P27930
    Human Recombinant Protein Products for IL1R2: 
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    Novus Biologicals IL1R2 Proteins
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    Sino Biological Recombinant Protein for IL1R2
    Sino Biological Cell Lysate for IL1R2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IL1R2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    IL1R2 for ontologies           About GeneDecksing



    IL1R2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for IL1R2 
    Cloud-Clone Corp. CLIAs for IL1R2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 1 receptor, type II 
    Immunoglobulin-like family of IL-1 receptors

    5/7 InterPro protein domains (see all 7):
     IPR013783 Ig-like_fold
     IPR015621 IL1-receptor_fam
     IPR007110 Ig-like_dom
     IPR004077 Interleukin-1_rcpt_II
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P27930

    ProtoNet protein and cluster: P27930

    3 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004077 Interleukin-1 receptor type II precursor signature


    UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    IL1R2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1R2_HUMAN, P27930
    Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by
    competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through
    non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially
    binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this
    complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

         Genatlas biochemistry entry for IL1R2:
    interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble
    form

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004908interleukin-1 receptor activity TAS10191101
    GO:0004910interleukin-1, Type II, blocking receptor activity IEA--
    GO:0005515protein binding IPI1830582
         
    IL1R2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL1R2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL1R2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1R2 
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): IL1R2 (NM_004633)
    Sino Biological Human cDNA Clone for IL1R2
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                         Customized lentivirus expression plasmids for stable overexpression of IL1R2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL1R2 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Interleukin-1 signaling
    IL1-mediated signaling events0.39
    Interleukin-1 signaling0.39
    3NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    NF-KappaB (p50-p65) Pathway0.72
    4ErbB4 Pathway
    TREM1 Pathway0.43
    HMGB1 Pathway0.36
    5Toll-like Receptor Pathway
    Toll-like Receptor Pathway0.36
    MAPK Pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL1R2 (see all 6)
        MAPK Signaling
    NF-KappaB (p50-p65) Pathway
    HMGB1 Pathway
    TREM1 Pathway
    p38 Signaling

    3 Tocris Bioscience Pathways for IL1R2
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    4 BioSystems Pathways for IL1R2
        MAPK signaling pathway
    Apoptosis Modulation and Signaling
    IL-1 Signaling Pathway
    IL1-mediated signaling events


    4        Reactome Pathways for IL1R2
        Interleukin-1 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    5/6         Kegg Pathways  (Kegg details for IL1R2) (see all 6):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
    Amoebiasis
    HTLV-I infection


    IL1R2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for IL1R2 (P279303 ENSP000003309594) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1RNP185103, ENSP000002592064I2D: score=4 STRING: ENSP00000259206
    IL1AP015833, ENSP000002633394I2D: score=3 STRING: ENSP00000263339
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=3 STRING: ENSP00000072516
    IL1BP015843, ENSP000002633414I2D: score=3 STRING: ENSP00000263341
    IL1R1ENSP000002339464STRING: ENSP00000233946
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS8898719

    IL1R2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL1R2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for IL1R2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    1 Novoseek inferred chemical compound relationship for IL1R2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 27.4 2 10085100 (1), 18346142 (1)

    Search CenterWatch for drugs/clinical trials and news about IL1R2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL1R2 gene (3 alternative transcripts): 
    NM_001261419.1  NM_004633.3  NM_173343.1  

    Unigene Cluster for IL1R2:

    Interleukin 1 receptor, type II
    Hs.25333  [show with all ESTs]
    Unigene Representative Sequence: NM_004633
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332549(uc002tbm.3) ENST00000464994 ENST00000493749 ENST00000393414(uc002tbn.3)
    ENST00000457817 ENST00000441002(uc002tbo.1) ENST00000482658 ENST00000474085
    ENST00000485335
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK130412.1 AK309161.1 BC012346.1 BC027733.2 BC039031.1 FJ200480.1 NR_048564.1 U64094.1 
    U74649.1 X59770.1 

    5 DOTS entries:

    DT.452355  DT.100749512  DT.95271208  DT.91674537  DT.95271209 

    24/74 AceView cDNA sequences (see all 74):

    BQ685045 BX343679 BM973329 CA448938 CR616861 BQ688121 BC039031 BQ084106 
    NM_004633 X59770 BU631559 CA307537 CA306304 CA415786 AU099372 AW236977 
    U64094 BX113594 NM_173343 CB157192 AI867567 BC012346 BC027733 AK130412 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IL1R2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                    -     -     -     -                             -                                         -               
    SP2:                                                                    -                                                         
    SP3:                                      -                             -                                                         
    SP4:                                                                    -                                                         
    SP5:                    -     -     -     -           -                 -                                                         


    ECgene alternative splicing isoforms for IL1R2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1R2 expression in normal human tissues (normalized intensities)      IL1R2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGCCAGCA
    IL1R2 Expression
    About this image


    IL1R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Chorion (Extraembryonic Tissues)
             Human Chorionic Mesenchymal Stromal Cells (HCMSC)   
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

    See IL1R2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL1R2

    SOURCE GeneReport for Unigene cluster: Hs.25333
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL1R2 (see all 6): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Atherosclerosis in human mouse rat
              T Helper Cell Differentiation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL1R2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1r21 , 5 interleukin 1 receptor, type II1, 5 70.72(n)1
    62.03(a)1
      1 (18.65 cM)5
    161781  NM_010555.41  NP_034685.11 
     400847685 
    chicken
    (Gallus gallus)
    Aves IL1R21 interleukin 1 receptor, type II 57.29(n)
    45.08(a)
      418715  XM_416914.3  XP_416914.2 
    lizard
    (Anolis carolinensis)
    Reptilia IL1R26
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL343243.1(1782367-1797806)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01054965.16
    CABZ01054962.16
    Uncharacterized protein
    14(a)
    13(a)
    many ↔ many
    many ↔ many
    9(54799636-54824493)
    9(54831713-54867535)


    ENSEMBL Gene Tree for IL1R2 (if available)
    TreeFam Gene Tree for IL1R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL1R2 gene
    IL1RL22  IL1RAPL22  IL1RAPL12  IL1RL12  IL1RAP2  IL18RAP2  IL18R12  IL1R12  
    1 SIMAP similar gene for IL1R2 using alignment to 3 protein entries:     IL1R2_HUMAN (see all proteins):
    IL1R1

    IL1R2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1104 SNPs in IL1R2 are shown (see all 1104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs721896231,2
    C--102280643(+) CTACA-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs67267131,2
    C,F,A,H--102606463(+) GGACAC/TAGTGC 2 -- us2k19Minor allele frequency- T:0.11NS EA NA WA 1208
    rs1826066131,2
    C--102606486(+) GAAGCA/GGGGCG 2 -- us2k10--------
    rs1122726721,2
    --102606490(+) CGGGGC/TGGAGG 2 -- us2k10--------
    rs41411341,2
    C,F,A,H--102606526(-) CCTGCT/CGGAGC 2 -- us2k130Minor allele frequency- C:0.18NS EA NA WA CSA 2773
    rs1163056481,2
    F--102606592(+) CTATGT/GAAGCA 2 -- us2k11Minor allele frequency- G:0.07WA 118
    rs772781381,2
    C,F--102606595(+) TGTAAG/ACAATT 2 -- us2k11Minor allele frequency- A:0.19WA 118
    rs170263631,2
    C,F,H--102606656(+) AATTCC/TTCCTT 2 -- us2k1 tfbs39Minor allele frequency- T:0.01NA NS EA WA 680
    rs67416151,2
    C,F,A,H--102606671(+) ATCACA/CAGATC 2 -- us2k15Minor allele frequency- C:0.05NS EA WA 536
    rs729885441,2
    C,F--102606701(+) GCCAAG/CAGCAG 2 -- us2k12Minor allele frequency- C:0.04WA 120

    HapMap Linkage Disequilibrium report for IL1R2 (102608306 - 102645006 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for IL1R2 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720456CNV Deletion23290073
    esv2720457CNV Deletion23290073
    esv2720458CNV Deletion23290073
    esv2720459CNV Deletion23290073
    esv2657953CNV Deletion23128226
    nsv874729CNV Loss21882294
    dgv4255n71CNV Loss21882294
    nsv874704CNV Loss21882294
    nsv874731CNV Loss21882294
    dgv4256n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147811    OMIM disorders: --

    20/37 diseases for IL1R2 (see all 37):    About MalaCards
    joint disorders    ascariasis    trichuriasis    mastitis
    chronic fatigue syndrome    endometriosis    patent ductus arteriosus    ankylosing spondylitis
    dengue hemorrhagic fever    hemorrhagic fever    spondylitis    acute pancreatitis
    periodontal disease    thrombosis    bronchiolitis    periodontitis
    gingivitis    choriocarcinoma    peritonitis    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for IL1R2:
    Endometriosis

    IL1R2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for IL1R2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometriosis 60.9 27 17709570 (4), 17517439 (4), 17919610 (4), 17482186 (2) (see all 10)
    polyarthritis 34.9 1 14586853 (1)
    systemic inflammatory response syndrome 34.4 1 8605344 (1)
    necrosis 32.2 10 15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 7)
    inflammation 9.52 3 9627018 (1), 7680670 (1), 17138054 (1)
    alzheimers disease 8.8 2 10216202 (1), 15843049 (1)
    rheumatoid arthritis 3.63 1 18780536 (1)
    sepsis 0 2 7680670 (2)
    tumors 0 9 15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 6)

    Genetic Association Database (GAD): IL1R2
    Human Genome Epidemiology (HuGE) Navigator: IL1R2 (34 documents)

    Export disorders for IL1R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1R2 gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with IL1R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PubMed id 1833184)1, 2, 3 McMahan C.J....Brannan C.I. (1991)
    2. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)1, 3, 9 Dale M. and Nicklin M.J. (1999)
    3. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Genome-wide association study of ankylosing spondylit is identifies non-MHC susceptibility loci. (PubMed id 20062062)1, 4 (2010)
    6. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. (PubMed id 20353565)1, 4 NAokki A....Kujala U.M. (2010)
    7. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    8. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    9. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    10. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7850 HGNC: 5994 AceView: IL1R2 Ensembl:ENSG00000115590 euGenes: HUgn7850
    ECgene: IL1R2 Kegg: 7850 H-InvDB: IL1R2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1R2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il1r2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL1R2 gene:
    Search GeneIP for patents involving IL1R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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