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IL1R2 Gene

protein-coding   GIFtS: 65
GCID: GC02P102608

Interleukin 1 Receptor, Type II


(Previous symbol: IL1RB)
  See IL1R2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 1 Receptor, Type II1 2     CD121 Antigen-Like Family Member B2 3
IL1RB1 2 3 5     IL-1 Type II Receptor2 3
Interleukin-1 Receptor Beta2 3     CD121b2
Interleukin-1 Receptor Type II2 3     IL1R2c2
CDw121b2 3     Antigen CDw121b2
IL-1R-22 3     Interleukin 1 Receptor Type II Variant 32
IL-1R-beta2 3     Interleukin-1 Receptor Type 22
IL-1RT-22 3     Type II Interleukin-1 Receptor, Beta2
IL-1RT22 3     CD121b Antigen3

External Ids:    HGNC: 59941   Entrez Gene: 78502   Ensembl: ENSG000001155907   OMIM: 1478115   UniProtKB: P279303   

Export aliases for IL1R2 gene to outside databases

Previous GC identifers: GC02P100479 GC02P101068 GC02P102212 GC02P102229 GC02P102066 GC02P101974 GC02P096372


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL1R2 Gene:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This
protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA),
and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to
antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and
three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in
multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble
proteins. A soluble protein is also produced by proteolytic cleavage. (provided by RefSeq, May 2012)

GeneCards Summary for IL1R2 Gene:
IL1R2 (interleukin 1 receptor, type II) is a protein-coding gene. Diseases associated with IL1R2 include aseptic meningitis. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RL2.

UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930
Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by
competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through
non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially
binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this
complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

summary for IL1R2 Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R2 (Interleukin 1 receptor, type II) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1R2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1R2 promoter sequence
   Search Chromatin IP Primers for IL1R2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12

IL1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1R2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102608:  view genomic region     (about GC identifiers)

Start:
102,608,306 bp from pter      End:
102,645,006 bp from pter
Size:
36,701 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930 (See protein sequence)
Recommended Name: Interleukin-1 receptor type 2 precursor  
Size: 398 amino acids; 45421 Da
Subunit: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex
1 PDB 3D structure from and Proteopedia for IL1R2:
3O4O (3D)    
Secondary accessions: D3DVJ5 Q6LCE6 Q9UE68
Alternative splicing: 2 isoforms:  P27930-1   P27930-2   

Explore the universe of human proteins at neXtProt for IL1R2: NX_P27930

Explore proteomics data for IL1R2 at MOPED

Post-translational modifications: 

  • A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a
    metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported1
  • Glycosylation2 at Asn66, Asn72, Asn112, Asn219, Asn277
  • Modification sites at PhosphoSitePlus

  • See IL1R2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001248348.1  NP_004624.1  

    ENSEMBL proteins: 
     ENSP00000330959   ENSP00000377066   ENSP00000408415   ENSP00000414611  
    Reactome Protein details: P27930

    IL1R2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for IL1R2
    OriGene MassSpec for IL1R2
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    Novus Biologicals IL1R2 Proteins
    Novus Biologicals IL1R2 Lysates
    Sino Biological Recombinant Protein for IL1R2
    Sino Biological Cell Lysate for IL1R2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IL1R2

     
    Search eBioscience for Proteins for IL1R2 

     
    antibodies-online proteins for IL1R2 (17 products) 

     
    antibodies-online peptides for IL1R2

    IL1R2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibody for IL1R2
    LSBio Antibodies in human, mouse, rat for IL1R2
    antibodies-online antibodies for IL1R2 (75 products) 

    IL1R2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for IL1R2 (IL-1 RII)         (see all)
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL1R2
    Cloud-Clone Corp. CLIAs for IL1R2
    Search eBioscience for ELISAs for IL1R2 
    antibodies-online kits for IL1R2 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 1 receptor, type II
    Immunoglobulin-like family of IL-1 receptors

    Selected InterPro protein domains (see all 7):
     IPR013783 Ig-like_fold
     IPR015621 IL-1_rcpt_fam
     IPR007110 Ig-like_dom
     IPR004077 IL-1_rcpt_II-typ
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P27930

    ProtoNet protein and cluster: P27930

    3 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004077 Interleukin-1 receptor type II precursor signature


    UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with IL1R2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1R2_HUMAN, P27930
    Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by
    competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through
    non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially
    binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this
    complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

         Genatlas biochemistry entry for IL1R2:
    interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble
    form

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004908interleukin-1 receptor activity TAS10191101
    GO:0004910interleukin-1, Type II, blocking receptor activity IEA--
    GO:0005515protein binding IPI1830582
         
    Find genes that share ontologies with IL1R2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL1R2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL1R2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1R2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1R2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL1R2:
    hsa-mir-26b-5p (MIRT029779)

    Block miRNA regulation of human, mouse, rat IL1R2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL1R2:
    hsa-miR-183*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IL1R2
    Predesigned siRNA for gene silencing in human, mouse, rat IL1R2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for IL1R2 (see all 11)
    OriGene ORF clones in mouse, rat for IL1R2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL1R2 (NM_004633)
    Sino Biological Human cDNA Clone for IL1R2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1R2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1R2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL1R2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL1R2_HUMAN, P27930: Isoform Short: Secreted
    IL1R2_HUMAN, P27930: Isoform Long: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol2
    nucleus2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL1R2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL1R2 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL-1 Signaling Pathway0.00
    IL1-mediated signaling events0.45
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    4ErbB4 Pathway
    TREM1 Pathway0.43
    HMGB1 Pathway0.36
    5MAPK Pathway
    Toll-like Receptor Pathway0.36
    MAPK Pathway0.36


    Find genes that share SuperPaths with IL1R2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL1R2
        IL-1 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL1R2 (see all 6)
        MAPK Signaling
    NF-KappaB (p50-p65) Pathway
    HMGB1 Pathway
    TREM1 Pathway
    p38 Signaling

    3 Tocris Bioscience Pathways for IL1R2
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    4 BioSystems Pathways for IL1R2
        MAPK signaling pathway
    Apoptosis Modulation and Signaling
    IL-1 Signaling Pathway
    IL1-mediated signaling events


    1 Reactome Pathway for IL1R2
        Interleukin-1 signaling


    Selected Kegg Pathways  (Kegg details for IL1R2) (see all 6):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
    Amoebiasis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1R2 (see all 6): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Atherosclerosis in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL1R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for IL1R2 (P279303 ENSP000003309594) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1RNP185103, ENSP000002592064I2D: score=4 STRING: ENSP00000259206
    IL1AP015833, ENSP000002633394I2D: score=3 STRING: ENSP00000263339
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=3 STRING: ENSP00000072516
    IL1BP015843, ENSP000002633414I2D: score=3 STRING: ENSP00000263341
    IL1R1ENSP000002339464STRING: ENSP00000233946
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS8898719
    GO:0019221cytokine-mediated signaling pathway TAS10191101

    Find genes that share ontologies with IL1R2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for IL1R2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    1 Novoseek inferred chemical compound relationship for IL1R2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 27.4 2 10085100 (1), 18346142 (1)



    Find genes that share compounds with IL1R2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL1R2 gene (3 alternative transcripts): 
    NM_001261419.1  NM_004633.3  NM_173343.1  

    Unigene Cluster for IL1R2:

    Interleukin 1 receptor, type II
    Hs.25333  [show with all ESTs]
    Unigene Representative Sequence: NM_004633
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332549(uc002tbm.3) ENST00000464994 ENST00000493749 ENST00000393414(uc002tbn.3)
    ENST00000457817 ENST00000441002(uc002tbo.1) ENST00000482658 ENST00000474085
    ENST00000485335
    miRNA
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    hsa-miR-183*
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): IL1R2 (NM_004633)
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    Primer
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    OriGene qPCR primer pairs and template standards for IL1R2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL1R2
      QuantiTect SYBR Green Assays in human, mouse, rat IL1R2
      QuantiFast Probe-based Assays in human, mouse, rat IL1R2

    Additional mRNA sequence: 

    AK130412.1 AK309161.1 BC012346.1 BC027733.2 BC039031.1 FJ200480.1 NR_048564.1 U64094.1 
    U74649.1 X59770.1 

    5 DOTS entries:

    DT.452355  DT.100749512  DT.95271208  DT.91674537  DT.95271209 

    Selected AceView cDNA sequences (see all 74):

    NM_004633 BQ084106 BQ685045 AK130412 AW196698 BX343679 AW236977 NM_173343 
    BM973329 CA306304 CA415786 AI867567 BX113594 CA307537 CA448938 U64094 
    BU631559 CB157192 BC039031 AU099372 BQ688121 CR616861 BC012346 BC027733 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL1R2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                    -     -     -     -                             -                                         -               
    SP2:                                                                    -                                                         
    SP3:                                      -                             -                                                         
    SP4:                                                                    -                                                         
    SP5:                    -     -     -     -           -                 -                                                         


    ECgene alternative splicing isoforms for IL1R2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL1R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGCCAGCA
    IL1R2 Expression
    About this image


    IL1R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    IL1R2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL1R2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25333
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1R2 (see all 6): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Atherosclerosis in human mouse rat
              T Helper Cell Differentiation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL1R2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1r21 , 5 interleukin 1 receptor, type II1, 5 70.71(n)1
    61.87(a)1
      1 (18.65 cM)5
    161781  NM_010555.41  NP_034685.11 
     400847685 
    chicken
    (Gallus gallus)
    Aves IL1R21 interleukin 1 receptor, type II 56.71(n)
    44.27(a)
      418715  XM_416914.4  XP_416914.3 
    lizard
    (Anolis carolinensis)
    Reptilia IL1R26
    interleukin 1 receptor, type II
    40(a)
    1 ↔ 1
    GL343243.1(1782367-1797806)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il1r21 interleukin 1 receptor, type 2 50.5(n)
    39.52(a)
      548430  NM_001015713.1  NP_001015713.1 


    ENSEMBL Gene Tree for IL1R2 (if available)
    TreeFam Gene Tree for IL1R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL1R2 gene
    IL1RL22  IL1RAPL22  IL1RAPL12  IL1RAP2  IL18RAP2  IL18R12  IL1RL12  IL1R12  
    1 SIMAP similar gene for IL1R2 using alignment to 3 protein entries:     IL1R2_HUMAN (see all proteins):
    IL1R1

    Find genes that share paralogs with IL1R2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL1R2 (see all 1104)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs721896231,2
    C--102280643(+) CTACA-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs67267131,2
    C,F,A,H--102606463(+) GGACAC/TAGTGC 2 -- us2k19Minor allele frequency- T:0.11NS EA NA WA 1208
    rs1826066131,2
    C--102606486(+) GAAGCA/GGGGCG 2 -- us2k10--------
    rs1122726721,2
    --102606490(+) CGGGGC/TGGAGG 2 -- us2k10--------
    rs41411341,2
    C,F,A,H--102606526(-) CCTGCT/CGGAGC 2 -- us2k130Minor allele frequency- C:0.18NS EA NA WA CSA 2773
    rs1163056481,2
    F--102606592(+) CTATGT/GAAGCA 2 -- us2k11Minor allele frequency- G:0.07WA 118
    rs772781381,2
    C,F--102606595(+) TGTAAG/ACAATT 2 -- us2k11Minor allele frequency- A:0.19WA 118
    rs170263631,2
    C,F,H--102606656(+) AATTCC/TTCCTT 2 -- us2k1 tfbs39Minor allele frequency- T:0.01NA NS EA WA 680
    rs67416151,2
    C,F,A,H--102606671(+) ATCACA/CAGATC 2 -- us2k15Minor allele frequency- C:0.05NS EA WA 536
    rs729885441,2
    C,F--102606701(+) GCCAAG/CAGCAG 2 -- us2k12Minor allele frequency- C:0.04WA 120

    HapMap Linkage Disequilibrium report for IL1R2 (102608306 - 102645006 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IL1R2 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720456CNV Deletion23290073
    esv2720457CNV Deletion23290073
    esv2720458CNV Deletion23290073
    esv2720459CNV Deletion23290073
    esv2657953CNV Deletion23128226
    nsv874729CNV Loss21882294
    dgv4255n71CNV Loss21882294
    nsv874704CNV Loss21882294
    nsv874731CNV Loss21882294
    dgv4256n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147811    OMIM disorders: --

    1 disease for IL1R2:    
    About MalaCards
    aseptic meningitis

    1 disease from the University of Copenhagen DISEASES database for IL1R2:
    Endometriosis

    Find genes that share disorders with IL1R2           About GenesLikeMe

    9 Novoseek inferred disease relationships for IL1R2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometriosis 60.9 27 17709570 (4), 17517439 (4), 17919610 (4), 17482186 (2) (see all 10)
    polyarthritis 34.9 1 14586853 (1)
    systemic inflammatory response syndrome 34.4 1 8605344 (1)
    necrosis 32.2 10 15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 7)
    inflammation 9.52 3 9627018 (1), 7680670 (1), 17138054 (1)
    alzheimers disease 8.8 2 10216202 (1), 15843049 (1)
    rheumatoid arthritis 3.63 1 18780536 (1)
    sepsis 0 2 7680670 (2)
    tumors 0 9 15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 6)

    Genetic Association Database (GAD): IL1R2
    Human Genome Epidemiology (HuGE) Navigator: IL1R2 (34 documents)

    Export disorders for IL1R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL1R2 gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with IL1R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PubMed id 1833184)1, 2, 3 McMahan C.J.... Sims J.E. (EMBO J. 1991)
    2. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)1, 3, 9 Dale M. and Nicklin M.J. (Genomics 1999)
    3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. (PubMed id 20062062)1, 4  ....Brown M.A. (Nat. Genet. 2010)
    6. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. (PubMed id 20353565)1, 4 NAokki A....Kujala U.M. (BMC Med. Genet. 2010)
    7. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    8. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    9. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    10. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7850 HGNC: 5994 AceView: IL1R2 Ensembl:ENSG00000115590 euGenes: HUgn7850
    ECgene: IL1R2 Kegg: 7850 H-InvDB: IL1R2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL1R2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il1r2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL1R2 gene:
    Search GeneIP for patents involving IL1R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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