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IL1R2 Gene

protein-coding GIFtS: 65
GCID: GC02P102608

Interleukin 1 Receptor, Type II

(Previous symbol: IL1RB)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Interleukin 1 Receptor, Type II¹ ²		CD121 Antigen-Like Family Member B² ³
IL1RB¹ ² ³ ⁵		IL-1 Type II Receptor² ³
Interleukin-1 Receptor Beta² ³		CD121b²
Interleukin-1 Receptor Type II² ³		IL1R2c²
CDw121b² ³		Antigen CDw121b²
IL-1R-2² ³		Interleukin 1 Receptor Type II Variant 3²
IL-1R-beta² ³		Interleukin-1 Receptor Type 2²
IL-1RT-2² ³		Type II Interleukin-1 Receptor, Beta²
IL-1RT2² ³		CD121b Antigen³

External Ids:	HGNC: 5994¹	Entrez Gene: 7850²	Ensembl: ENSG00000115590⁷	OMIM: 147811⁵	UniProtKB: P27930³

Export aliases for IL1R2 gene to outside databases

Previous GC identifers: GC02P100479 GC02P101068 GC02P102212 GC02P102229 GC02P102066 GC02P101974 GC02P096372

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL1R2 Gene:

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This

protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA),

and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to

antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and

three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in

multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble

proteins. A soluble protein is also produced by proteolytic cleavage. (provided by RefSeq, May 2012)

GeneCards Summary for IL1R2 Gene:

IL1R2 (interleukin 1 receptor, type II) is a protein-coding gene. Diseases associated with IL1R2 include ascariasis, and trichuriasis. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type II, blocking receptor activity. An important paralog of this gene is IL1RL2.

UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930

Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by

competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through

non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially

binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this

complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

summary for IL1R2 Gene:

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They

control many different cellular functions including proliferation, differentiation and cell

survival/apoptosis but are also involved in several pathophysiological processes including viral infections

and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the

innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can

be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,

IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.

Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R2 (Interleukin 1 receptor, type II) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NT_005403.18 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the IL1R2 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1R2 promoter sequence

Search Chromatin IP Primers for IL1R2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1R2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q12

IL1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1R2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P102608: view genomic region (about GC identifiers)

Start:	102,608,306 bp from pter	End:	102,645,006 bp from pter
Size:	36,701 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930 (See protein sequence)

Recommended Name: Interleukin-1 receptor type 2 precursor

Size: 398 amino acids; 45421 Da

Subunit: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex

1 PDB 3D structure from and Proteopedia for IL1R2:

3O4O (3D)

Secondary accessions: D3DVJ5 Q6LCE6 Q9UE68

Alternative splicing: 2 isoforms: P27930-1 P27930-2

Explore the universe of human proteins at neXtProt for IL1R2: NX_P27930

Explore proteomics data for IL1R2 at MOPED

Post-translational modifications:

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a

metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported¹

Glycosylation² at Asn66, Asn72, Asn112, Asn219, Asn277

Modification sites at PhosphoSitePlus

See IL1R2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001248348.1 NP_004624.1

ENSEMBL proteins:

ENSP00000330959 ENSP00000377066 ENSP00000408415 ENSP00000414611

Reactome Protein details: P27930

IL1R2 Human Recombinant Protein Products:

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	Novus Biologicals IL1R2 Proteins Novus Biologicals IL1R2 Lysates
	Sino Biological Recombinant Protein for IL1R2 Sino Biological Cell Lysate for IL1R2
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	Cloud-Clone Corp. Proteins for IL1R2

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	Abcam antibodies for IL1R2
	Cloud-Clone Corp. Antibodies for IL1R2
	ThermoFisher Antibody for IL1R2
	LSBio Antibodies in human, mouse, rat for IL1R2

IL1R2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for IL1R2
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	GenScript Custom Assay Services for IL1R2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for IL1R2 Cloud-Clone Corp. CLIAs for IL1R2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

IL: Interleukins and interleukin receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 1 receptor, type II

Immunoglobulin-like family of IL-1 receptors

Selected InterPro protein domains (see all 7):

IPR013783 Ig-like_fold

IPR015621 IL-1_rcpt_fam

IPR007110 Ig-like_dom

IPR004077 IL-1_rcpt_II-typ

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P27930

ProtoNet protein and cluster: P27930

3 Blocks protein domains:

IPB003599 Immunoglobulin subtype

IPB004074 Interleukin-1 receptor type I and type II family signature

IPB004077 Interleukin-1 receptor type II precursor signature

UniProtKB/Swiss-Prot: IL1R2_HUMAN, P27930

Similarity: Belongs to the interleukin-1 receptor family

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

IL1R2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: IL1R2_HUMAN, P27930

Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by

competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through

non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially

binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this

complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors

Genatlas biochemistry entry for IL1R2:

interleukin 1 receptor,type 2,expressed in B and T cell,with a transmembrane and an alternatively spliced soluble

form

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004908	interleukin-1 receptor activity	TAS	10191101
GO:0004910	interleukin-1, Type II, blocking receptor activity	IEA	--
GO:0005515	protein binding	IPI	1830582

IL1R2 for ontologies About GeneDecksing

Animal Models:

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genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1R2

miRNA Products:		miRTarBase miRNAs that target IL1R2: hsa-mir-26b-5p (MIRT029779)

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		1 qRT-PCR Assays for microRNA that regulate IL1R2:
		hsa-miR-183*
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		Predesigned siRNA for gene silencing in human, mouse, rat IL1R2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL1R2

Clone Products:		OriGene clones in human, mouse for IL1R2 (see all 11) OriGene ORF clones in mouse, rat for IL1R2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IL1R2 (NM_004633)
		Sino Biological Human cDNA Clone for IL1R2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1R2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1R2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL1R2
		Browse ESI BIO Cell Lines and PureStem Progenitors for IL1R2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

IL1R2_HUMAN, P27930: Isoform Short: Secreted

IL1R2_HUMAN, P27930: Isoform Long: Cell membrane; Single-pass type I membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
plasma membrane	5
cytosol	2
nucleus	2
golgi apparatus	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral component of membrane	IEA	--

IL1R2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL1R2 About (see all 17)

See pathways by source

SuperPath

Contained pathways About

Interleukin-1 signaling

	Interleukin-1 signaling	0.45			IL-1 Signaling Pathway	0.00
	IL1-mediated signaling events	0.45

MAPK signaling pathway

MAPK signaling pathway

0.50

MAPK signaling pathway

0.50

NF-KappaB Family Pathway

NF-KappaB (p50-p65) Pathway

0.72

NF-KappaB Family Pathway

0.72

ErbB4 Pathway

TREM1 Pathway

0.43

HMGB1 Pathway

0.36

MAPK Pathway

Toll-like Receptor Pathway

0.36

MAPK Pathway

0.36

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for IL1R2

IL-1 Family Signaling Pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL1R2 (see all 6)

	MAPK Signaling
	NF-KappaB (p50-p65) Pathway
	HMGB1 Pathway
	TREM1 Pathway
	p38 Signaling

3 Tocris Bioscience Pathways for IL1R2

	Akt Pathway
	Toll-like Receptor Pathway
	MAPK Pathway

4 BioSystems Pathways for IL1R2

	MAPK signaling pathway
	Apoptosis Modulation and Signaling
	IL-1 Signaling Pathway
	IL1-mediated signaling events

1 Reactome Pathway for IL1R2

Interleukin-1 signaling

Selected Kegg Pathways (Kegg details for IL1R2) (see all 6):

	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	Hematopoietic cell lineage
	Amoebiasis
	HTLV-I infection

IL1R2 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including IL1R2 (see all 6):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Cell Surface Markers in human mouse rat

NFKB Signaling Targets in human mouse rat

Atherosclerosis in human mouse rat

T Helper Cell Differentiation in human mouse rat

Interactions:

GeneGlobe Interaction Network for IL1R2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for IL1R2 (P27930³ ENSP00000330959⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL1RN	P18510³, ENSP00000259206⁴	I2D: score=4 STRING: ENSP00000259206
IL1A	P01583³, ENSP00000263339⁴	I2D: score=3 STRING: ENSP00000263339
IL1RAP	Q9NPH3³, ENSP00000072516⁴	I2D: score=3 STRING: ENSP00000072516
IL1B	P01584³, ENSP00000263341⁴	I2D: score=3 STRING: ENSP00000263341
IL1R1	ENSP00000233946⁴	STRING: ENSP00000233946

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	8898719
GO:0019221	cytokine-mediated signaling pathway	TAS	10191101

IL1R2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for IL1R2 available from Tocris Bioscience About this table

Compound	Action	CAS #
AS 101	Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release	[106566-58-9]
Pirfenidone	Antifibrotic agent; regulates cytokine levels in vivo	[53179-13-8]
GIT 27	Immunomodulator; reduces production of pro-inflammatory cytokines	[6501-72-0]
4-IPP	Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate	[41270-96-6]
Thalidomide	TNF-alpha synthesis inhibitor	[50-35-1]

1 Novoseek inferred chemical compound relationship for IL1R2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dexamethasone	27.4	2	10085100 (1), 18346142 (1)

IL1R2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IL1R2 gene (3 alternative transcripts):

NM_001261419.1 NM_004633.3 NM_173343.1

Unigene Cluster for IL1R2:

Interleukin 1 receptor, type II

Hs.25333 [show with all ESTs]

Unigene Representative Sequence: NM_004633

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000332549(uc002tbm.3) ENST00000464994 ENST00000493749 ENST00000393414(uc002tbn.3)

ENST00000457817 ENST00000441002(uc002tbo.1) ENST00000482658 ENST00000474085

ENST00000485335

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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		1 qRT-PCR Assays for microRNA that regulate IL1R2:
		hsa-miR-183*
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for IL1R2
		Predesigned siRNA for gene silencing in human, mouse, rat IL1R2

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		GenScript: all cDNA clones in your preferred vector (see all 2): IL1R2 (NM_004633)
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat IL1R2
		QuantiTect SYBR Green Assays in human, mouse, rat IL1R2
		QuantiFast Probe-based Assays in human, mouse, rat IL1R2

Additional mRNA sequence:

AK130412.1 AK309161.1 BC012346.1 BC027733.2 BC039031.1 FJ200480.1 NR_048564.1 U64094.1

U74649.1 X59770.1

5 DOTS entries:

DT.452355 DT.100749512 DT.95271208 DT.91674537 DT.95271209

Selected AceView cDNA sequences (see all 74):

NM_004633 BQ084106 BQ685045 AK130412 AW196698 BX343679 AW236977 NM_173343

BM973329 CA306304 CA415786 AI867567 BX113594 CA307537 CA448938 U64094

BU631559 CB157192 BC039031 AU099372 BQ688121 CR616861 BC012346 BC027733

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL1R2 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11
SP1:							-		-		-		-										-														-
SP2:																							-
SP3:													-										-
SP4:																							-
SP5:							-		-		-		-				-						-

ECgene alternative splicing isoforms for IL1R2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL1R2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGGCCAGCA

About this image

IL1R2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 10) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Cerebral Cortex

Blood (Hematopoietic System) fully expand to see all 2 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow

Epithelial Cells
Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

Bone (Muscoskeletal System)
Bone Marrow

Eye (Sensory Organs)
Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

IL1R2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

IL1R2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.25333

Pathway & Disease-focused RT² Profiler PCR Arrays including IL1R2 (see all 6):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Cell Surface Markers in human mouse rat

NFKB Signaling Targets in human mouse rat

Atherosclerosis in human mouse rat

T Helper Cell Differentiation in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for IL1R2 OriGene qSTAR qPCR primer pairs in human, mouse for IL1R2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat IL1R2
		QuantiTect SYBR Green Assays in human, mouse, rat IL1R2
		QuantiFast Probe-based Assays in human, mouse, rat IL1R2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL1R2 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il1r2^{1 , 5}	interleukin 1 receptor, type II^{1, 5}	70.71(n)¹ 61.87(a)¹		1 (18.65 cM)⁵ 16178¹ NM_010555.4¹ NP_034685.1¹ 40084768⁵
chicken (Gallus gallus)	Aves	IL1R2¹	interleukin 1 receptor, type II	56.71(n) 44.27(a)		418715 XM_416914.4 XP_416914.3
lizard (Anolis carolinensis)	Reptilia	IL1R2⁶	interleukin 1 receptor, type II	40(a)	1 ↔ 1	GL343243.1(1782367-1797806)
tropical clawed frog (Xenopus tropicalis)	Amphibia	il1r2¹	interleukin 1 receptor, type 2	50.5(n) 39.52(a)		548430 NM_001015713.1 NP_001015713.1

ENSEMBL Gene Tree for IL1R2 (if available)
TreeFam Gene Tree for IL1R2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for IL1R2 gene

IL1RL2² IL1RAPL2² IL1RAPL1² IL1RAP² IL18RAP² IL18R1² IL1RL1² IL1R1²

1 SIMAP similar gene for IL1R2 using alignment to 3 protein entries: IL1R2_HUMAN (see all proteins):

IL1R1

IL1R2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72189623^1,2	C	--	102280643(+)	`CTACA-/A/AA AAAAA`	3	--	int¹		0	--	--	--	--
rs6726713^1,2	C,F,A,H	--	102606463(+)	`GGACAC/TAGTGC`	2	--	us2k¹		9		NS EA NA WA	1208
rs182606613^1,2	C	--	102606486(+)	`GAAGCA/GGGGCG`	2	--	us2k¹		0	--	--	--	--
rs112272672^1,2		--	102606490(+)	`CGGGGC/TGGAGG`	2	--	us2k¹		0	--	--	--	--
rs4141134^1,2	C,F,A,H	--	102606526(-)	`CCTGCT/CGGAGC`	2	--	us2k¹		30		NS EA NA WA CSA	2773
rs116305648^1,2	F	--	102606592(+)	`CTATGT/GAAGCA`	2	--	us2k¹		1		WA	118
rs77278138^1,2	C,F	--	102606595(+)	`TGTAAG/ACAATT`	2	--	us2k¹		1		WA	118
rs17026363^1,2	C,F,H	--	102606656(+)	`AATTCC/TTCCTT`	2	--	us2k¹ tfbs³		9		NA NS EA WA	680
rs6741615^1,2	C,F,A,H	--	102606671(+)	`ATCACA/CAGATC`	2	--	us2k¹		5		NS EA WA	536
rs72988544^1,2	C,F	--	102606701(+)	`GCCAAG/CAGCAG`	2	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for IL1R2 (102608306 - 102645006 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for IL1R2 (see all 19): About this table

Variant ID	Type	Subtype	PubMed ID
esv2720456	CNV	Deletion	23290073
esv2720457	CNV	Deletion	23290073
esv2720458	CNV	Deletion	23290073
esv2720459	CNV	Deletion	23290073
esv2657953	CNV	Deletion	23128226
nsv874729	CNV	Loss	21882294
dgv4255n71	CNV	Loss	21882294
nsv874704	CNV	Loss	21882294
nsv874731	CNV	Loss	21882294
dgv4256n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147811 OMIM disorders: --

Selected diseases for IL1R2 (see all 41):
About MalaCards

ascariasis trichuriasis endometriosis mastitis

chronic fatigue syndrome sepsis patent ductus arteriosus ankylosing spondylitis

dengue hemorrhagic fever venous thrombosis spondylitis hemorrhagic fever

acute pancreatitis periodontal disease periodontitis bronchiolitis

gingivitis choriocarcinoma osteoarthritis alzheimer's disease

1 disease from the University of Copenhagen DISEASES database for IL1R2:

Endometriosis

IL1R2 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

9 Novoseek inferred disease relationships for IL1R2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
endometriosis	60.9	27	17709570 (4), 17517439 (4), 17919610 (4), 17482186 (2) (see all 10)
polyarthritis	34.9	1	14586853 (1)
systemic inflammatory response syndrome	34.4	1	8605344 (1)
necrosis	32.2	10	15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 7)
inflammation	9.52	3	9627018 (1), 7680670 (1), 17138054 (1)
alzheimers disease	8.8	2	10216202 (1), 15843049 (1)
rheumatoid arthritis	3.63	1	18780536 (1)
sepsis	0	2	7680670 (2)
tumors	0	9	15716832 (1), 18605463 (1), 11360299 (1), 18780536 (1) (see all 6)

Genetic Association Database (GAD): IL1R2
Human Genome Epidemiology (HuGE) Navigator: IL1R2 (34 documents)

Export disorders for IL1R2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL1R2 gene, integrated from 10 sources (see all 140):
(articles sorted by number of sources associating them with IL1R2)

Utopia: connect your pdf to the dynamic
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A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. (PubMed id 1833184)^{1, 2, 3} McMahan C.J.... Sims J.E. (EMBO J. 1991)
Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)^{1, 3, 9} Dale M. and Nicklin M.J. (Genomics 1999)
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)^{1, 4} Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. (PubMed id 20062062)^{1, 4} ....Brown M.A. (Nat. Genet. 2010)
Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. (PubMed id 20353565)^{1, 4} NAokki A....Kujala U.M. (BMC Med. Genet. 2010)
Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)^{1, 4} Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)^{1, 4} Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)^{1, 4} Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7850	HGNC: 5994	AceView: IL1R2	Ensembl:ENSG00000115590	euGenes: HUgn7850
ECgene: IL1R2	Kegg: 7850	H-InvDB: IL1R2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IL1R2	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/il1r2/

Intellectual Property for IL1R2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL1R2 gene:
Search GeneIP for patents involving IL1R2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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IL1R2 Gene

Interleukin 1 Receptor, Type II

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