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Aliases for IL1R1 Gene

Aliases for IL1R1 Gene

  • Interleukin 1 Receptor, Type I 2 3
  • IL1RA 3 4 6
  • CD121 Antigen-Like Family Member A 3 4
  • Interleukin-1 Receptor Type I 3 4
  • Interleukin-1 Receptor Alpha 3 4
  • IL-1R-Alpha 3 4
  • IL-1RT-1 3 4
  • IL-1R-1 3 4
  • IL-1RT1 3 4
  • IL1R 3 4
  • P80 3 4
  • Interleukin 1 Receptor Alpha, Type I 3
  • Interleukin-1 Receptor Type 1 3
  • CD121a Antigen 4
  • D2S1473 3
  • CD121A 3
  • IL1RT1 4

External Ids for IL1R1 Gene

Previous Symbols for IL1R1 Gene

  • IL1R
  • IL1RA

Summaries for IL1R1 Gene

Entrez Gene Summary for IL1R1 Gene

  • This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

GeneCards Summary for IL1R1 Gene

IL1R1 (Interleukin 1 Receptor, Type I) is a Protein Coding gene. Diseases associated with IL1R1 include schnitzler syndrome and cinca syndrome. Among its related pathways are MAPK signaling pathway and NF-KappaB Family Pathway. GO annotations related to this gene include signal transducer activity and protease binding. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL1R1 Gene

  • Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Tocris Summary for IL1R1 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1R1 Gene

Genomics for IL1R1 Gene

Genomic Location for IL1R1 Gene

Start:
102,064,544 bp from pter
End:
102,179,874 bp from pter
Size:
115,331 bases
Orientation:
Plus strand

Genomic View for IL1R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1R1 Gene

Regulatory Elements for IL1R1 Gene

Proteins for IL1R1 Gene

  • Protein details for IL1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14778-IL1R1_HUMAN
    Recommended name:
    Interleukin-1 receptor type 1
    Protein Accession:
    P14778
    Secondary Accessions:
    • Q587I7

    Protein attributes for IL1R1 Gene

    Size:
    569 amino acids
    Molecular mass:
    65402 Da
    Quaternary structure:
    • The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.

    Three dimensional structures from OCA and Proteopedia for IL1R1 Gene

neXtProt entry for IL1R1 Gene

Proteomics data for IL1R1 Gene at MOPED

Post-translational modifications for IL1R1 Gene

  • A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
  • Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn100, Asn193, Asn233, Asn249, Asn263, and Asn297

No data available for DME Specific Peptides for IL1R1 Gene

Domains for IL1R1 Gene

Gene Families for IL1R1 Gene

HGNC:
  • CD :CD molecules
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

IL1R1_HUMAN
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • P14778
  • Contains 1 TIR domain.:
    • P14778
Family:
  • Belongs to the interleukin-1 receptor family.:
    • P14778
genes like me logo Genes that share domains with IL1R1: view

Function for IL1R1 Gene

Molecular function for IL1R1 Gene

GENATLAS Biochemistry: interleukin 1,receptor type 1,high affinity,expressed in T cell and fibroblast,with two alternatively spliced isoforms,secreted and cytoplasmic,forming a complex after induction of IL1 and recruitment of IRAK through its association with IL1RAP
UniProtKB/Swiss-Prot Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene Ontology (GO) - Molecular Function for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004871 signal transducer activity TAS 2530587
GO:0004888 transmembrane signaling receptor activity TAS 2530587
GO:0004908 interleukin-1 receptor activity IDA 10383454
GO:0004909 interleukin-1, Type I, activating receptor activity IEA --
genes like me logo Genes that share ontologies with IL1R1: view
genes like me logo Genes that share phenotypes with IL1R1: view

Animal Models for IL1R1 Gene

MGI Knock Outs for IL1R1:

miRNA for IL1R1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL1R1 Gene

Localization for IL1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1R1 Gene

Membrane; Single-pass type I membrane protein. Cell membrane. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1R1 Gene COMPARTMENTS Subcellular localization image for IL1R1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 2
nucleus 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2530587
GO:0009986 cell surface IEA --
GO:0016020 membrane IDA 16477012
genes like me logo Genes that share ontologies with IL1R1: view

Pathways for IL1R1 Gene

genes like me logo Genes that share pathways with IL1R1: view

Interacting Proteins for IL1R1 Gene

Gene Ontology (GO) - Biological Process for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9120302
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway TAS 1833184
GO:0019221 cytokine-mediated signaling pathway --
GO:0050727 regulation of inflammatory response IEA --
genes like me logo Genes that share ontologies with IL1R1: view

Compounds for IL1R1 Gene

(5) Tocris Compounds for IL1R1 Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines [6501-72-0]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(1) Drugbank Compounds for IL1R1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Anakinra
  • ICIL-1RA
143090-92-0 target antagonist

(124) Novoseek inferred chemical compound relationships for IL1R1 Gene

Compound -log(P) Hits PubMed IDs
anakinra 91.8 91
endotoxin 60.3 33
il 10 53.1 8
pge2 45.2 36
etanercept 44 9
genes like me logo Genes that share compounds with IL1R1: view

Transcripts for IL1R1 Gene

Unigene Clusters for IL1R1 Gene

Interleukin 1 receptor, type I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1R1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7:

Relevant External Links for IL1R1 Gene

GeneLoc Exon Structure for
IL1R1
ECgene alternative splicing isoforms for
IL1R1

Expression for IL1R1 Gene

mRNA expression in normal human tissues for IL1R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IL1R1 Gene

SOURCE GeneReport for Unigene cluster for IL1R1 Gene Hs.701982

genes like me logo Genes that share expressions with IL1R1: view

Orthologs for IL1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1R1 36
  • 98.87 (n)
  • 98.4 (a)
IL1R1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL1R1 36
  • 79.96 (n)
  • 72.76 (a)
IL1R1 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1R1 36
  • 84.36 (n)
  • 77.5 (a)
IL1R1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1r1 36
  • 75.41 (n)
  • 69.37 (a)
Il1r1 16
Il1r1 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1R1 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1R1 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1r1 36
  • 75 (n)
  • 68.31 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 31 (a)
ManyToMany
IL1R1 37
  • 41 (a)
ManyToMany
IL1RL2 36
  • 57.94 (n)
  • 43.7 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il1r1 36
  • 53.83 (n)
  • 41.6 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01054962.1 37
  • 25 (a)
ManyToMany
CABZ01054965.1 37
  • 25 (a)
ManyToMany
LOC799204 36
  • 44.18 (n)
  • 30.32 (a)
Species with no ortholog for IL1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1R1 Gene

ENSEMBL:
Gene Tree for IL1R1 (if available)
TreeFam:
Gene Tree for IL1R1 (if available)

Paralogs for IL1R1 Gene

Paralogs for IL1R1 Gene

genes like me logo Genes that share paralogs with IL1R1: view

Variants for IL1R1 Gene

Sequence variations from dbSNP and Humsavar for IL1R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs871195 -- 102,118,377(-) ataaa(G/T)gatac intron-variant
rs871376 -- 102,094,712(-) CATAA(A/G)TTGAA intron-variant
rs871656 -- 102,154,822(+) CTGCA(A/T)GTTGT intron-variant
rs871657 -- 102,154,881(+) ATGCT(C/T)CAGAA intron-variant
rs871658 -- 102,155,405(-) GTGCT(C/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1R1 Gene

Variant ID Type Subtype PubMed ID
nsv874734 CNV Loss 21882294

Relevant External Links for IL1R1 Gene

HapMap Linkage Disequilibrium report
IL1R1
Human Gene Mutation Database (HGMD)
IL1R1

Disorders for IL1R1 Gene

(96) Novoseek inferred disease relationships for IL1R1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 77.2 133
inflammation 70.7 76
schnitzler syndrome 66.5 4
rheumatoid arthritis 66 87
cinca syndrome 63.8 1

Relevant External Links for IL1R1

Genetic Association Database (GAD)
IL1R1
Human Genome Epidemiology (HuGE) Navigator
IL1R1
genes like me logo Genes that share disorders with IL1R1: view

No data available for UniProtKB/Swiss-Prot for IL1R1 Gene

Publications for IL1R1 Gene

  1. Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort. (PMID: 17083033) Do H. … Zagury J.F. (J. Infect. Dis. 2006) 3 23 25 49
  2. X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. (PMID: 10903327) Vigers G.P.A. … Brandhuber B.J. (J. Biol. Chem. 2000) 3 4 23
  3. Genetic factors determine extent of bone loss in inflammatory bowel disease. (PMID: 11040178) Schulte C.M. … Schulte K.M. (Gastroenterology 2000) 3 23 49
  4. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. (PMID: 11083263) Moos V. … MA1ller B. (Arthritis Rheum. 2000) 3 23 49
  5. Polymorphism of the cytokine genes and IgA nephropathy. (PMID: 11849463) SyrjAonen J. … Pasternack A. (Kidney Int. 2002) 3 23 49

Products for IL1R1 Gene

Sources for IL1R1 Gene

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