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Aliases for IL1R1 Gene

Aliases for IL1R1 Gene

  • Interleukin 1 Receptor Type 1 2 3
  • Interleukin 1 Receptor, Type I 2 3 5
  • CD121 Antigen-Like Family Member A 3 4
  • Interleukin-1 Receptor Type I 3 4
  • Interleukin-1 Receptor Alpha 3 4
  • IL-1R-Alpha 3 4
  • IL-1RT-1 3 4
  • IL-1R-1 3 4
  • IL-1RT1 3 4
  • IL1RA 3 4
  • IL1R 3 4
  • P80 3 4
  • Interleukin 1 Receptor Alpha, Type I 3
  • Interleukin-1 Receptor 2
  • CD121a Antigen 4
  • D2S1473 3
  • Type I 2
  • CD121A 3
  • IL1RT1 4

External Ids for IL1R1 Gene

Previous HGNC Symbols for IL1R1 Gene

  • IL1R
  • IL1RA

Previous GeneCards Identifiers for IL1R1 Gene

  • GC02P100634
  • GC02P101223
  • GC02P102285
  • GC02P102391
  • GC02P102228
  • GC02P102125
  • GC02P102053
  • GC02P102681
  • GC02P096534

Summaries for IL1R1 Gene

Entrez Gene Summary for IL1R1 Gene

  • This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

GeneCards Summary for IL1R1 Gene

IL1R1 (Interleukin 1 Receptor Type 1) is a Protein Coding gene. Diseases associated with IL1R1 include schnitzler syndrome and cinca syndrome. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include signal transducer activity and protease binding. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL1R1 Gene

  • Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Tocris Summary for IL1R1 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL1R1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1R1 Gene

Genomics for IL1R1 Gene

Regulatory Elements for IL1R1 Gene

Genomic Location for IL1R1 Gene

Chromosome:
2
Start:
102,064,544 bp from pter
End:
102,179,874 bp from pter
Size:
115,331 bases
Orientation:
Plus strand

Genomic View for IL1R1 Gene

Genes around IL1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1R1 Gene

Proteins for IL1R1 Gene

  • Protein details for IL1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14778-IL1R1_HUMAN
    Recommended name:
    Interleukin-1 receptor type 1
    Protein Accession:
    P14778
    Secondary Accessions:
    • Q587I7

    Protein attributes for IL1R1 Gene

    Size:
    569 amino acids
    Molecular mass:
    65402 Da
    Quaternary structure:
    • The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.

    Three dimensional structures from OCA and Proteopedia for IL1R1 Gene

neXtProt entry for IL1R1 Gene

Proteomics data for IL1R1 Gene at MOPED

Post-translational modifications for IL1R1 Gene

  • A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
  • Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
  • Glycosylation at Asn 100, Asn 193, Asn 233, Asn 249, Asn 263, and Asn 297
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IL1R1 Gene

Domains & Families for IL1R1 Gene

Suggested Antigen Peptide Sequences for IL1R1 Gene

Graphical View of Domain Structure for InterPro Entry

P14778

UniProtKB/Swiss-Prot:

IL1R1_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1R1: view

Function for IL1R1 Gene

Molecular function for IL1R1 Gene

GENATLAS Biochemistry:
interleukin 1,receptor type 1,high affinity,expressed in T cell and fibroblast,with two alternatively spliced isoforms,secreted and cytoplasmic,forming a complex after induction of IL1 and recruitment of IRAK through its association with IL1RAP
UniProtKB/Swiss-Prot Function:
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene Ontology (GO) - Molecular Function for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 2530587
GO:0004908 interleukin-1 receptor activity IEA,IDA 10383454
GO:0004909 interleukin-1, Type I, activating receptor activity IEA --
GO:0005515 protein binding IEA,IPI 12925853
genes like me logo Genes that share ontologies with IL1R1: view
genes like me logo Genes that share phenotypes with IL1R1: view

Animal Models for IL1R1 Gene

MGI Knock Outs for IL1R1:

Animal Model Products

miRNA for IL1R1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1R1 Gene

Localization for IL1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1R1 Gene

Membrane; Single-pass type I membrane protein. Cell membrane. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1R1 Gene COMPARTMENTS Subcellular localization image for IL1R1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
cytosol 2
endoplasmic reticulum 2
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 16477012
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with IL1R1: view

Pathways & Interactions for IL1R1 Gene

genes like me logo Genes that share pathways with IL1R1: view

Interacting Proteins for IL1R1 Gene

SIGNOR curated interactions for IL1R1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 1833184
GO:0010286 heat acclimation IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0030728 ovulation IEA --
genes like me logo Genes that share ontologies with IL1R1: view

Drugs & Compounds for IL1R1 Gene

(75) Drugs for IL1R1 Gene - From: Novoseek, DGIdb, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anakinra Approved Pharma antagonist, Target IL-1 receptor antagonist 0
OMS-103HP Investigational Pharma Target 0
SD118 Investigational Pharma Target 0
Dexamethasone sodium phosphate Pharma 0
IL-1 Pharma 0

(58) Additional Compounds for IL1R1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AF 12198
185413-30-3
Lyn peptide inhibitor
222018-18-0
R 7050
303997-35-5
Ro 26-4550 trifluoroacetate
1217448-66-2
YM 90709
163769-88-8

(5) Tocris Compounds for IL1R1 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8

(1) ApexBio Compounds for IL1R1 Gene

Compound Action Cas Number
Dexamethasone Sodium Phosphate 55203-24-2
genes like me logo Genes that share compounds with IL1R1: view

Transcripts for IL1R1 Gene

Unigene Clusters for IL1R1 Gene

Interleukin 1 receptor, type I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1R1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7:

Relevant External Links for IL1R1 Gene

GeneLoc Exon Structure for
IL1R1
ECgene alternative splicing isoforms for
IL1R1

Expression for IL1R1 Gene

mRNA expression in normal human tissues for IL1R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IL1R1 Gene

This gene is overexpressed in Placenta (47.2), Liver (14.3), and Gallbladder (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1R1 Gene



SOURCE GeneReport for Unigene cluster for IL1R1 Gene Hs.701982

genes like me logo Genes that share expression patterns with IL1R1: view

Protein tissue co-expression partners for IL1R1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IL1R1 Gene

Orthologs for IL1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL1R1 35
  • 79.96 (n)
  • 72.76 (a)
IL1R1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1R1 35
  • 84.36 (n)
  • 77.5 (a)
IL1R1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1r1 35
  • 75.41 (n)
  • 69.37 (a)
Il1r1 16
Il1r1 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1R1 35
  • 98.87 (n)
  • 98.4 (a)
IL1R1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1r1 35
  • 75 (n)
  • 68.31 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1R1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1R1 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1RL2 35
  • 57.94 (n)
  • 43.7 (a)
-- 36
  • 31 (a)
ManyToMany
IL1R1 36
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il1r1 35
  • 53.83 (n)
  • 41.6 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799204 35
  • 44.18 (n)
  • 30.32 (a)
CABZ01054962.1 36
  • 25 (a)
ManyToMany
CABZ01054965.1 36
  • 25 (a)
ManyToMany
Species with no ortholog for IL1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1R1 Gene

ENSEMBL:
Gene Tree for IL1R1 (if available)
TreeFam:
Gene Tree for IL1R1 (if available)

Paralogs for IL1R1 Gene

Paralogs for IL1R1 Gene

genes like me logo Genes that share paralogs with IL1R1: view

Variants for IL1R1 Gene

Sequence variations from dbSNP and Humsavar for IL1R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2228139 - 102,165,189(+) TAATG(A/C/G)ACAAG reference, missense, utr-variant-5-prime
rs28362304 - 102,174,626(+) TGTCA(C/T)GTTGA reference, missense
rs887998 -- 102,113,847(-) AAATC(A/G)AAAAT intron-variant
rs949963 -- 102,153,326(-) CACGT(A/G)GCACT intron-variant
rs951192 -- 102,169,394(-) TTAAT(G/T)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1R1 Gene

Variant ID Type Subtype PubMed ID
nsv874734 CNV Loss 21882294

Variation tolerance for IL1R1 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1R1 Gene

HapMap Linkage Disequilibrium report
IL1R1
Human Gene Mutation Database (HGMD)
IL1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1R1 Gene

Disorders for IL1R1 Gene

MalaCards: The human disease database

(33) MalaCards diseases for IL1R1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schnitzler syndrome
  • chronic urticaria with gammapathy
cinca syndrome
  • chronic infantile neurological cutaneous articular syndrome
paratyphoid fever
  • paratyphoid
pyogenic arthritis, pyoderma gangrenosum and acne
  • familial recurrent arthritis
vulvar vestibulitis syndrome
  • familial neurocardiogenic syncope
- elite association - COSMIC cancer census association via MalaCards
Search IL1R1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL1R1

Genetic Association Database (GAD)
IL1R1
Human Genome Epidemiology (HuGE) Navigator
IL1R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1R1
genes like me logo Genes that share disorders with IL1R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1R1 Gene

Publications for IL1R1 Gene

  1. X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. (PMID: 10903327) Vigers G.P.A. … Brandhuber B.J. (J. Biol. Chem. 2000) 3 4 23 67
  2. Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. (PMID: 19488045) Rao J.S. … Kim H.W. (Mol. Psychiatry 2010) 3 23
  3. Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP. (PMID: 20054003) McLaughlin M. … Vandenbroeck K. (J. Biol. Chem. 2010) 3 23
  4. Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases. (PMID: 19117745) Vasakova M. … Striz I. (Respir Med 2009) 3 23
  5. Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist. (PMID: 19702713) Khalilzadeh O. … Amirzargar A. (Clin. Experiment. Ophthalmol. 2009) 3 23

Products for IL1R1 Gene

Sources for IL1R1 Gene

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