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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1R1 Gene

protein-coding   GIFtS: 70
GCID: GC02P102681

interleukin 1 receptor, type I


(Previous symbols: IL1R, IL1RA)
 Explore 227 diseases affiliated with
IL1R1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL1R1    

Aliases
for IL1R1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 1 Receptor, Type I1 2     IL-1RT12 3
IL1RA1 2 3 5     CD121 Antigen-Like Family Member A2 3
IL1R1 2 3     P802
CD121A1 2     Antigen CD121a2
D2S14731 2     Interleukin 1 Receptor Alpha, Type I2
Interleukin-1 Receptor Alpha2 3     Interleukin Receptor 12
Interleukin-1 Receptor Type I2 3     Interleukin-1 Receptor Type 12
IL-1R-12 3     IL1RT13
IL-1R-Alpha1     CD121a Antigen3
IL-1RT-12 3     P802

External Ids:    HGNC: 59931   Entrez Gene: 35542   Ensembl: ENSG000001155947   OMIM: 1478105   UniProtKB: P147783   

Export aliases for IL1R1 gene to outside databases

Previous GC identifers: GC02P100634 GC02P101223 GC02P102285 GC02P102391 GC02P102228 GC02P102125 GC02P102053 GC02P102136 GC02P096534


Summaries
for IL1R1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL1R1:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein
is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA).
It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with
interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1
(IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778
Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to
form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B,
MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or
IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and
binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex

summary for IL1R1:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R1 (Interleukin 1 receptor, type I)


Genomic Views
for IL1R1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1R1 gene promoter:
         GR   AP-1   ATF-2   MyoD   GATA-1   AREB6   IRF-7A   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12

IL1R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1R1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102681:  view genomic region     (about GC identifiers)

Start:
 102,681,004 bp from pter      End:
 102,796,334 bp from pter
Size:
 115,331 bases      Orientation:
 plus strand

Proteins
for IL1R1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778 (See protein sequence)
Recommended Name: Interleukin-1 receptor type 1 precursor  
Size: 569 amino acids; 65402 Da
Subunit: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1
Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted
4 PDB 3D structures from and Proteopedia for IL1R1:
1G0Y (3D)        1IRA (3D)        1ITB (3D)        4DEP (3D)    
Secondary accessions: Q587I7

Explore the universe of human proteins at neXtProt for IL1R1: NX_P14778

Post-translational modifications:

  • A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding)1
  • Rapidely phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory
    • subunit PIK3R11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14778

    • IL1R1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000868.1  
    ENSEMBL proteins: 
     ENSP00000401646   ENSP00000386776   ENSP00000415366   ENSP00000386555   ENSP00000387131  
     ENSP00000411627   ENSP00000410461   ENSP00000393296   ENSP00000386478   ENSP00000386380  
     ENSP00000407017   ENSP00000408101   ENSP00000390349   ENSP00000233946  
    Reactome Protein details: P14778
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL1R1 (IL-1 RI)
    Enzo Life Sciences proteins for IL1R1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: IL1R1
    OriGene Custom Protein Services for IL1R1 
    GenScript Custom Purified and Recombinant Proteins Services for IL1R1
    Novus Biologicals IL1R1 Proteins
    Novus Biologicals IL1R1 Lysates
    Sino Biological Recombinant Protein for IL1R1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IL1R1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS2530587
    GO:0009986cell surface IEA--


    IL1R1 for ontologies           About GeneDecksing



    IL1R1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL1R1
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    ThermoFisher Antibodies for IL1R1

    Assay Products for IL1R1: 
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    R&D Systems ELISAs for IL1R1 (IL-1 RI)
    GenScript Custom Assay Services for IL1R1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IL1R1

    Protein Domains /
    Families
    for IL1R1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL1R1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR015621 IL1-receptor_fam
     IPR007110 Ig-like_dom
     IPR004076 IL1R_rcpt
     IPR003599 Ig_sub
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry P14778

    ProtoNet protein and cluster: P14778

    4 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004075 Interleukin-1 receptor type I family signature
    IPB004076 Interleukin-1 receptor type I precursor signature


    UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    Function
    for IL1R1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778
    Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to
    form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B,
    MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or
    IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and
    binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex

         Genatlas biochemistry entry for IL1R1:
    interleukin 1,receptor type 1,high affinity,expressed in T cell and fibroblast,with two alternatively spliced
    isoforms,secreted and cytoplasmic,forming a complex after induction of IL1 and recruitment of IRAK through its
    association with IL1RAP

    miRNA
    Products:            		miRTarBase miRNAs that target IL1R1:
    hsa-mir-197 (MIRT004217)

    OriGene 3'-UTR Clone: IL1R1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1R1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1R1 (see all 21):
    hsa-miR-124* hsa-miR-4328 hsa-miR-125a-3p hsa-miR-548s hsa-miR-374a* hsa-miR-515-5p hsa-miR-548a-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IL1R1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL1R1 (see all 7)
    OriGene shRNA RFP: IL1R1
    OriGene siRNA: IL1R1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1R1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IL1R1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL1R1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL1R1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL1R1 (NM_000877)
    Sino Biological Human cDNA Clone for IL1R1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1R1 

    Cell Line
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    Search LifeMap BioReagents cell lines for IL1R1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0004871signal transducer activity TAS2530587
    GO:0004888transmembrane signaling receptor activity TAS2530587
    GO:0004908interleukin-1 receptor activity IDA10383454
    GO:0004909interleukin-1, Type I, activating receptor activity IEA--


    IL1R1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IL1R1:
     Decreased viability of wild-ty  Enable proliferation in B-Raf  

    Animal Models:
         Mouse knock-outs for IL1R1: Il1r1tm1Roml Il1r1tm1Imx
         15/20 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Il1r1) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    IL1R1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IL1R1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    2PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Glucocorticoid Receptor Signaling0.27
    		PGC1Alpha Pathway0.33
    		Cytokine-cytokine receptor interaction0.26
    3Immune response_Bacterial infections in normal airways
    		Immune response_Bacterial infections in normal airways1.00
    		IL-1 beta-dependent CFTR expression0.43
    		Bacterial infections in CF airways0.78
    4Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    5Immune response_IL-1 signaling pathway
    		Immune response_IL-1 signaling pathway1.00
    		Immune response IL-1 signaling pathway0.98

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for IL1R1
        Transcription NF-kB signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Immune response IL-1 signaling pathway

    2 R&D Systems Pathways for IL1R1
        Inflammasome Activation Pathways
    Th17 Differentiation

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL1R1 (see all 21)
        MAPK Signaling
    14-3-3 Induced Apoptosis
    TRAF Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    3 Tocris Bioscience Pathways for IL1R1
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for IL1R1 (see all 6)
        Immune response Bacterial infections in normal airways
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription NF-kB signaling pathway
    Bacterial infections in CF airways
    IL-1 beta-dependent CFTR expression

    5/8 BioSystems Pathways for IL1R1 (see all 8) 
        Apoptosis Modulation and Signaling
    MAPK signaling pathway
    IL-1 Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    5        Reactome Pathways for IL1R1
        IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
    Interleukin-1 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    5/6         Kegg Pathways  (Kegg details for IL1R1) (see all 6):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    Apoptosis
    Osteoclast differentiation
    Hematopoietic cell lineage


    IL1R1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for IL1R1 (P147781, 2, 3 ENSP000002339464) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1RNP185102, 3, ENSP000002592064MINT-25085 I2D: score=7 STRING: ENSP00000259206
    TRAF6Q9Y4K31, 3EBI-525905,EBI-359276 I2D: score=3 
    IL1BP015842, 3, ENSP000002633414MINT-24831 I2D: score=8 STRING: ENSP00000263341
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=6 STRING: ENSP00000072516
    IL1AP015833, ENSP000002633394I2D: score=4 STRING: ENSP00000263339
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS9120302
    GO:0007166cell surface receptor signaling pathway TAS1833184
    GO:0019221cytokine-mediated signaling pathway ----
    GO:0030728ovulation ----
    GO:0045087innate immune response IEA--


    IL1R1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL1R1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL1R1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for IL1R1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AF 12198 Potent, selective human type I IL-1 receptor antagonist [185413-30-3]

    1 DrugBank Compound for IL1R1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AnakinraICIL-1RA (see all 6)143090-92-0targetantagonist12817089 17083033 12355453 17352828 11752352 17498496 10210771

    10/124 Novoseek chemical compound relationships for IL1R1 gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anakinra 91.8 101 15201943 (2), 12563672 (2), 18474815 (2), 14989428 (2) (see all 79)
    endotoxin 60.3 44 9853276 (5), 2147233 (2), 8299563 (1), 7936030 (1) (see all 28)
    il 10 53.1 10 10645445 (1), 20456103 (1), 20305143 (1), 15289211 (1) (see all 8)
    pge2 45.2 49 9322624 (4), 8166209 (4), 1315688 (3), 9416852 (2) (see all 22)
    etanercept 44 9 10641509 (1), 17349557 (1), 19808132 (1), 12008859 (1) (see all 9)
    gp 130 42.1 9 15570310 (2), 15373762 (2), 9629951 (1), 17824899 (1) (see all 7)
    infliximab 40.4 13 10641509 (1), 17349557 (1), 16088130 (1), 19808132 (1) (see all 13)
    ribonucleic acid 36.8 10 9322624 (3), 9506755 (2), 1371258 (1), 8131405 (1) (see all 6)
    adalimumab 36.5 7 17349557 (1), 19808132 (1), 18492052 (1), 15103244 (1) (see all 7)
    polysulfone 36.3 10 9096797 (2), 8649615 (2), 11775226 (1)

    Search CenterWatch for drugs/clinical trials and news about IL1R1 

    Transcripts
    for IL1R1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL1R1 gene: 
    NM_000877.2  

    Unigene Cluster for IL1R1:

    Interleukin 1 receptor, type I
    Hs.701982  [show with all ESTs]
    Unigene Representative Sequence: M27492
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452403 ENST00000409929 ENST00000424272 ENST00000409589 ENST00000409329
    ENST00000450319 ENST00000428279 ENST00000442590 ENST00000409288 ENST00000410023(uc010fix.3 uc002tbq.3 uc002tbr.3)
    ENST00000413623 ENST00000430171 ENST00000422532 ENST00000233946

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IL1R1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1R1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1R1 (see all 21):
    hsa-miR-124* hsa-miR-4328 hsa-miR-125a-3p hsa-miR-548s hsa-miR-374a* hsa-miR-515-5p hsa-miR-548a-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IL1R1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL1R1 (see all 7)
    OriGene shRNA RFP: IL1R1
    OriGene siRNA: IL1R1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1R1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL1R1 (see all 4)
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    GenScript: all cDNA clones in your preferred vector: IL1R1 (NM_000877)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1R1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL1R1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1R1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1R1

    Additional cDNA sequence: 

    AK314433.1 BC067506.1 BC067507.1 BC067508.1 BC075062.2 BC075063.2 M27492.1 X16896.1 

    11 DOTS entries:

    DT.95276134  DT.100641000  DT.91758010  DT.100718102  DT.101981927  DT.120950369  DT.91758012  DT.95276135 
    DT.120950395  DT.40315463  DT.99966351 

    24/217 AceView cDNA sequences (see all 217):

    BU661823 BF431688 AI052793 BE842651 CK429603 CB250402 CR595183 CR621155 
    AA337207 BG548330 AA639640 CD013912 CD013913 BQ021163 CA414781 AU140044 
    BM991119 BP343440 AL597915 BQ771575 BE502035 CA314813 AL548240 BC075063 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IL1R1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                    -                                                                             -               
    SP2:                    -                             -     -                                         -               
    SP3:                    -                 -     -                                                     -               
    SP4:                    -     -                                                                       -               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for IL1R1

    Expression
    for IL1R1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATCACGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL1R1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Early Embryo (Zygote)Morula8-Cell EmbryoEarly Embryo
    Early Embryo (Zygote)ZygoteZygoteEarly Embryo
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    HeartMyocardiumCardiac FibroblastsEpicardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Trophoblast-like cells (Generation of tropho...)

    See IL1R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL1R1

    SOURCE GeneReport for Unigene cluster: Hs.701982
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL1R1 (see all 17): 
              Th17 Response in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Leukemia in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R1

    Orthologs
    for IL1R1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL1R1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IL1R11 interleukin 1 receptor, type I 57.03(n)
    43.09(a)    		   396481  NM_205485.1  NP_990816.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IL1R16
    		 --
    		 39(a)
    		 1 → many
    		 GL343243.1(1719891-1732131)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01054965.16
    CABZ01054962.16
    		 --
    		 25(a)
    24(a)
    		 many ↔ many
    many ↔ many
    		 9(54799636-54824493)
    9(54831713-54867535)


    ENSEMBL Gene Tree for IL1R1 (if available)
    TreeFam Gene Tree for IL1R1 (if available) 

    Paralogs
    for IL1R1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL1R1 gene
    IL1RAPL22  IL1RL22  IL1RAP2  IL1RAPL12  IL18RAP2  IL18R12  SIGIRR2  IL1R22  
    IL1RL12  
    3 SIMAP similar genes for IL1R1 using alignment to 13 protein entries:     IL1R1_HUMAN (see all proteins):
    IL1RL1    IL1RL2    IL1R2

    IL1R1 for paralogs           About GeneDecksing



    Genomic Variants
    for IL1R1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/787 NCBI SNPs in IL1R1 are shown (see all 787)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1443139501,2
    		--102768406(+) GGGGGC/TGCTGA 1 -- us2k10--------
    rs782578751,2
    		F,--102768442(+) GGGGCC/TGATGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1164551931,2
    		--102768652(+) AAAAGG/AAGGGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs101838691,2
    		C,F,A,H,--102768658(+) AGGGAA/GAATGA 1 -- us2k1 trp35Minor allele frequency- G:0.19NA WA EA 362
    rs101947161,2
    		C,F,A,H,--102768689(+) GGCCAG/AGTGCA 1 -- us2k16Minor allele frequency- A:0.29WA NA EA 364
    rs1864925241,2
    		--102768761(+) GAGATC/GGAGAC 1 -- us2k10--------
    rs19783301,2
    		C,F,--102768855(-) CCTGAG/ATAGCT 1 -- us2k14Minor allele frequency- A:0.38NA WA 8
    rs362147841,2
    		C,--102768919(+) TAGATC/TGCACC 1 -- us2k10--------
    rs362147851,2
    		C,--102768960(+) ACTCCA/GTCTCA 1 -- us2k10--------
    rs1143472811,2
    		C,--102769036(+) AGAAGC/TTTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL1R1 (102681004 - 102796334 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL1R1: --
    Human Gene Mutation Database (HGMD): IL1R1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL1R1
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1R1

    Disorders / Diseases
    for IL1R1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL1R1 for disorders           About GeneDecksing

    OMIM gene information: 147810    OMIM disorders: --

    20/227 diseases for IL1R1 (see all 227):    About MalaCards
    muckle-wells syndrome    interleukin receptor    cryopyrin-associated periodic syndrome    post-transplant lymphoproliferative disease
    graft versus host disease    chronic infantile neurological cutaneous articular syndrome    adult-onset still's disease    familial cold autoinflammatory syndrome
    subacute sclerosing panencephalitis    langerhans-cell histiocytosis    acute graft versus host disease    bacterial vaginosis
    vulvar vestibulitis syndrome    hemolytic-uremic syndrome    wells syndrome    alopecia areata
    adult respiratory distress syndrome    periventricular leukomalacia    pyoderma gangrenosum    status asthmaticus

    10/96 Novoseek disease relationships for IL1R1 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 77.2 404 8225219 (5), 7897303 (4), 8808459 (4), 9065108 (3) (see all 99)
    inflammation 70.7 92 7584121 (2), 17888220 (2), 16009838 (2), 1834697 (2) (see all 71)
    schnitzler syndrome 66.5 4 16096327 (1), 20064173 (1), 18371052 (1), 18480937 (1)
    rheumatoid arthritis 66 92 15201943 (2), 8670316 (2), 7748221 (2), 15225683 (2) (see all 66)
    cinca syndrome 63.8 1 16532456 (1)
    muckle-wells syndrome 57.7 3 16014694 (1), 12815153 (1), 16531551 (1)
    tumors 54.9 316 8225219 (5), 7897303 (4), 8808459 (4), 9065108 (3) (see all 99)
    arthritis 54.5 22 8006890 (4), 20028520 (2), 10088773 (2), 17947302 (1) (see all 12)
    cold hypersensitivity 51 2 17336710 (1), 15541451 (1)
    systemic inflammatory response syndrome 50.4 20 1834697 (3), 8124953 (2), 7611862 (2), 9386664 (2) (see all 10)

    Genetic Association Database (GAD): IL1R1
    Human Genome Epidemiology (HuGE) Navigator: IL1R1 (157 documents)

    Export disorders for IL1R1 gene to outside databases

    Publications
    for IL1R1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1R1 gene, integrated from 9 sources (see all 1382):
    (articles sorted by number of sources associating them with IL1R1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. (PubMed id 10903327)1, 2, 9 Vigers G.P.A.... Brandhuber B.J. (2000)
    2. Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. (PubMed id 9062193)1, 2, 9 Vigers G.P.A.... Brandhuber B.J. (1997)
    3. Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort. (PubMed id 17083033)1, 7, 9 Do H....Zagury J.F. (2006)
    4. Association of single nucleotide polymorphisms within cytokine genes with juvenile idiopathic arthritis in the Czech population. (PubMed id 15170937)1, 4, 9 Cinek O....Slavcev A. (2004)
    5. [The association between interleukin-1 receptor antagonist genotype and chronic periodontitis of Uighur patients] (PubMed id 14680589)1, 4, 9 Zhong L.J....Yang A.L. (2003)
    6. Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in post-menopausal Mediterranean women. (PubMed id 12240899)1, 4, 9 Fontova R....Richart C. (2002)
    7. Polymorphism of the cytokine genes and IgA nephropathy. (PubMed id 11849463)1, 4, 9 Syrjanen J....Pasternack A. (2002)
    8. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)1, 3, 9 Dale M. and Nicklin M.J. (1999)
    9. Genotyping for cytokine polymorphisms: allele frequencies in the Italian population. (PubMed id 12558814)1, 4, 9 Uboldi de Capei M.U....Curtoni E.S. (2003)
    10. CC chemokine receptor 5 and interleukin-1 receptor antagonist gene polymorphisms in patients with primary Sjogren's syndrome. (PubMed id 12412204)1, 4, 9 Petrek M....Bosak V. (2002)

    External Searches for IL1R1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IL1R1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3554 HGNC: 5993 AceView: IL1R1 Ensembl:ENSG00000115594 euGenes: HUgn3554
    ECgene: IL1R1 Kegg: 3554 H-InvDB: IL1R1

    Other Databases showing IL1R1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL1R1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1R1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il1r1/

    Intellectual Property
    for IL1R1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL1R1 gene:
    Search GeneIP for patents involving IL1R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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