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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1R1 Gene

protein-coding   GIFtS: 71
GCID: GC02P102681

Interleukin 1 Receptor, Type I


(Previous symbols: IL1R, IL1RA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 1 Receptor, Type I1 2     CD121A2
IL1RA1 2 3 5     D2S14732
IL1R1 2 3     P802
Interleukin-1 Receptor Alpha2 3     Antigen CD121a2
Interleukin-1 Receptor Type I2 3     Interleukin 1 Receptor Alpha, Type I2
IL-1R-12 3     Interleukin Receptor 12
IL-1R-alpha2 3     Interleukin-1 Receptor Type 12
IL-1RT-12 3     IL1RT13
IL-1RT12 3     CD121a Antigen3
CD121 Antigen-Like Family Member A2 3     p803

External Ids:    HGNC: 59931   Entrez Gene: 35542   Ensembl: ENSG000001155947   OMIM: 1478105   UniProtKB: P147783   

Export aliases for IL1R1 gene to outside databases

Previous GC identifers: GC02P100634 GC02P101223 GC02P102285 GC02P102391 GC02P102228 GC02P102125 GC02P102053 GC02P102136 GC02P096534


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1R1 Gene:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This
protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type
I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses.
This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and
interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome
2q12. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1R1 Gene: 
IL1R1 (interleukin 1 receptor, type I) is a protein-coding gene. Diseases associated with IL1R1 include schnitzler syndrome, and raynaud disease, and among its related super-pathways are STAT3 Pathway and IL-1 beta-dependent CFTR expression. GO annotations related to this gene include protease binding and signal transducer activity. An important paralog of this gene is IL1R2.

UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778
Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP
to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of
NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP,
MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with
comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex

summary for IL1R1 Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1R1 (Interleukin 1 receptor, type I) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1R1 gene promoter:
         GR   AP-1   ATF-2   MyoD   GATA-1   AREB6   IRF-7A   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL1R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12

IL1R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1R1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102681:  view genomic region     (about GC identifiers)

Start:
102,681,004 bp from pter      End:
102,796,334 bp from pter
Size:
115,331 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778 (See protein sequence)
Recommended Name: Interleukin-1 receptor type 1 precursor  
Size: 569 amino acids; 65402 Da
Subunit: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1
Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted
5 PDB 3D structures from and Proteopedia for IL1R1:
1G0Y (3D)        1IRA (3D)        1ITB (3D)        4DEP (3D)        4GAF (3D)    
Secondary accessions: Q587I7

Explore the universe of human proteins at neXtProt for IL1R1: NX_P14778

Explore proteomics data for IL1R1 at MOPED 

Post-translational modifications:

  • UniProtKB: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding)
  • UniProtKB: Rapidely phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase
    regulatory subunit PIK3R1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14778

  • IL1R1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL1R1 Protein Expression
    REFSEQ proteins: NP_000868.1  
    ENSEMBL proteins: 
     ENSP00000401646   ENSP00000386776   ENSP00000415366   ENSP00000386555   ENSP00000387131  
     ENSP00000411627   ENSP00000410461   ENSP00000393296   ENSP00000386478   ENSP00000386380  
     ENSP00000407017   ENSP00000408101   ENSP00000390349   ENSP00000233946  
    Reactome Protein details: P14778
    Human Recombinant Protein Products for IL1R1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL1R1 (IL-1 RI)
    Enzo Life Sciences proteins for IL1R1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL1R1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IL1R1
    GenScript Custom Purified and Recombinant Proteins Services for IL1R1
    Novus Biologicals IL1R1 Proteins
    Novus Biologicals IL1R1 Lysates
    Sino Biological Recombinant Protein for IL1R1
    Sino Biological Cell Lysate for IL1R1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IL1R1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS2530587
    GO:0009986cell surface IEA--
    GO:0016020membrane IDA16477012

    IL1R1 for ontologies           About GeneDecksing



    IL1R1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL1R1
    R&D Systems Antibodies for IL1R1 (IL-1 RI)
    OriGene Antibodies for IL1R1
    OriGene Custom Antibody Services for IL1R1
    GenScript Custom Superior Antibodies Services for IL1R1
    Novus Biologicals IL1R1 Antibodies
    Abcam antibodies for IL1R1
    Cloud-Clone Corp. Antibodies for IL1R1 
    ThermoFisher Antibodies for IL1R1
    LSBio Antibodies in human, mouse, rat for IL1R1 

    Assay Products for IL1R1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL1R1
    R&D Systems ELISAs for IL1R1 (IL-1 RI)         (see all)
    GenScript Custom Assay Services for IL1R1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL1R1 
    Cloud-Clone Corp. CLIAs for IL1R1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 1 receptor, type I 
    Immunoglobulin-like family of IL-1 receptors

    5/8 InterPro protein domains (see all 8):
     IPR013098 Ig_I-set
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold
     IPR015621 IL1-receptor_fam
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P14778

    ProtoNet protein and cluster: P14778

    4 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB004074 Interleukin-1 receptor type I and type II family signature
    IPB004075 Interleukin-1 receptor type I family signature
    IPB004076 Interleukin-1 receptor type I precursor signature


    UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    IL1R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1R1_HUMAN, P14778
    Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP
    to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of
    NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP,
    MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with
    comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex

         Genatlas biochemistry entry for IL1R1:
    interleukin 1,receptor type 1,high affinity,expressed in T cell and fibroblast,with two alternatively spliced
    isoforms,secreted and cytoplasmic,forming a complex after induction of IL1 and recruitment of IRAK through its
    association with IL1RAP

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0004871signal transducer activity TAS2530587
    GO:0004888transmembrane signaling receptor activity TAS2530587
    GO:0004908interleukin-1 receptor activity IDA10383454
    GO:0004909interleukin-1, Type I, activating receptor activity IEA--
         
    IL1R1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL1R1:
     Decreased viability of wild-ty  Enable proliferation in B-Raf  

         15/20 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il1r1) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    IL1R1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL1R1: Il1r1tm1Roml Il1r1tm1Imx

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL1R1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL1R1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1R1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1R1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL1R1:
    hsa-mir-197 (MIRT004217)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1R1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1R1 (see all 21):
    hsa-miR-124* hsa-miR-4328 hsa-miR-125a-3p hsa-miR-548s hsa-miR-374a* hsa-miR-515-5p hsa-miR-548a-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL1R1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL1R1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1R1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL1R1
    Sirion Biotech Customized adenovirus for overexpression of IL1R1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL1R1 (see all 8)
    OriGene ORF clones in mouse, rat for IL1R1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL1R1 (NM_000877)
    Sino Biological Human cDNA Clone for IL1R1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1R1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1R1
    Sirion Biotech Customized lentivirus for stable overexpression of IL1R1 
                         Customized lentivirus expression plasmids for stable overexpression of IL1R1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL1R1
    Search LifeMap BioReagents cell lines for IL1R1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL1R1 About   (see all 33)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL-1 beta-dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    IL-1 Signaling Pathway0.32
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Interleukin-1 signaling
    IL1-mediated signaling events0.39
    Interleukin-1 signaling0.39
    5Toll Comparative Pathway
    Immune response IL-1 signaling pathway0.41
    IL-1 Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for IL1R1
        Transcription NF-kB signaling pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Immune response IL-1 signaling pathway

    2 R&D Systems Pathways for IL1R1
        Inflammasome Activation Pathways
    Th17 Differentiation

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL1R1 (see all 21)
        MAPK Signaling
    14-3-3 Induced Apoptosis
    TRAF Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    3 Tocris Bioscience Pathways for IL1R1
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for IL1R1 (see all 6)
        Immune response Bacterial infections in normal airways
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription NF-kB signaling pathway
    Bacterial infections in CF airways
    IL-1 beta-dependent CFTR expression

    5/8 BioSystems Pathways for IL1R1 (see all 8)
        MAPK signaling pathway
    Apoptosis Modulation and Signaling
    IL-1 Signaling Pathway
    Spinal Cord Injury
    Monoamine Transport


    4        Reactome Pathways for IL1R1
        Interleukin-1 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    5/8         Kegg Pathways  (Kegg details for IL1R1) (see all 8):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    Apoptosis
    Osteoclast differentiation


    IL1R1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for IL1R1 (P147781, 2, 3 ENSP000002339464) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1RNP185102, 3, ENSP000002592064MINT-25085 I2D: score=7 STRING: ENSP00000259206
    TRAF6Q9Y4K31, 3EBI-525905,EBI-359276 I2D: score=3 
    IL1BP015842, 3, ENSP000002633414MINT-24831 I2D: score=8 STRING: ENSP00000263341
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=6 STRING: ENSP00000072516
    IL1AP015833, ENSP000002633394I2D: score=4 STRING: ENSP00000263339
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS9120302
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway TAS1833184
    GO:0019221cytokine-mediated signaling pathway ----
    GO:0070498interleukin-1-mediated signaling pathway IDA10383454

    IL1R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL1R1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for IL1R1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    1 DrugBank Compound for IL1R1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AnakinraICIL-1RA (see all 6)143090-92-0targetantagonist12817089 17083033 12355453 17352828 11752352 17498496 10210771

    10/124 Novoseek inferred chemical compound relationships for IL1R1 gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anakinra 91.8 101 15201943 (2), 12563672 (2), 18474815 (2), 14989428 (2) (see all 79)
    endotoxin 60.3 44 9853276 (5), 2147233 (2), 8299563 (1), 7936030 (1) (see all 28)
    il 10 53.1 10 10645445 (1), 20456103 (1), 20305143 (1), 15289211 (1) (see all 8)
    pge2 45.2 49 9322624 (4), 8166209 (4), 1315688 (3), 9416852 (2) (see all 22)
    etanercept 44 9 10641509 (1), 17349557 (1), 19808132 (1), 12008859 (1) (see all 9)
    gp 130 42.1 9 15570310 (2), 15373762 (2), 9629951 (1), 17824899 (1) (see all 7)
    infliximab 40.4 13 10641509 (1), 17349557 (1), 16088130 (1), 19808132 (1) (see all 13)
    ribonucleic acid 36.8 10 9322624 (3), 9506755 (2), 1371258 (1), 8131405 (1) (see all 6)
    adalimumab 36.5 7 17349557 (1), 19808132 (1), 18492052 (1), 15103244 (1) (see all 7)
    polysulfone 36.3 10 9096797 (2), 8649615 (2), 11775226 (1)

    Search CenterWatch for drugs/clinical trials and news about IL1R1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL1R1 gene: 
    NM_000877.2  

    Unigene Cluster for IL1R1:

    Interleukin 1 receptor, type I
    Hs.701982  [show with all ESTs]
    Unigene Representative Sequence: M27492
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452403 ENST00000409929 ENST00000424272 ENST00000409589 ENST00000409329
    ENST00000450319 ENST00000428279 ENST00000442590 ENST00000409288 ENST00000410023(uc010fix.3 uc002tbq.3 uc002tbr.3)
    ENST00000413623 ENST00000430171 ENST00000422532 ENST00000233946
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1R1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1R1 (see all 21):
    hsa-miR-124* hsa-miR-4328 hsa-miR-125a-3p hsa-miR-548s hsa-miR-374a* hsa-miR-515-5p hsa-miR-548a-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL1R1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL1R1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1R1
    Clone
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    Additional mRNA sequence: 

    AK314433.1 BC067506.1 BC067507.1 BC067508.1 BC075062.2 BC075063.2 M27492.1 X16896.1 

    11 DOTS entries:

    DT.95276134  DT.100641000  DT.91758010  DT.100718102  DT.101981927  DT.120950369  DT.91758012  DT.120950395 
    DT.40315463  DT.95276135  DT.99966351 

    24/217 AceView cDNA sequences (see all 217):

    AA034981 CB852209 BC075062 BF771539 BC075063 CA414781 BP343611 CA314813 
    CR621155 BP343440 NM_000877 BE502035 BE842651 AU140044 CD013912 AI052793 
    CD013913 CK130245 AA337207 CB250402 BU500964 BQ018991 AL548240 BU661823 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IL1R1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                    -                                                                             -               
    SP2:                    -                             -     -                                         -               
    SP3:                    -                 -     -                                                     -               
    SP4:                    -     -                                                                       -               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for IL1R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1R1 expression in normal human tissues (normalized intensities)      IL1R1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCACGGAT
    IL1R1 Expression
    About this image


    IL1R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
             fetal cartilage   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
             Human Calvarial Osteoblasts (HCO)   
     
     Fibroblast
             Detroit 551
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
             HyStem+BMP4-induced E15 cells

    See IL1R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL1R1

    SOURCE GeneReport for Unigene cluster: Hs.701982
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL1R1 (see all 17): 
              Th17 Response in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Leukemia in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1R1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL1R1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1r11 , 5 interleukin 1 receptor, type I1, 5 75.41(n)1
    69.19(a)1
      1 (18.81 cM)5
    161771  NM_008362.21  NP_032388.11 
     402250805 
    chicken
    (Gallus gallus)
    Aves IL1R11 interleukin 1 receptor, type I 57.03(n)
    43.09(a)
      396481  NM_205485.1  NP_990816.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    37(a)
    1 → many
    GL343243.1(1720514-1747264)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01054962.16
    CABZ01054965.16
    Uncharacterized protein
    24(a)
    24(a)
    many ↔ many
    many ↔ many
    9(54831713-54867535)
    9(54799636-54824493)


    ENSEMBL Gene Tree for IL1R1 (if available)
    TreeFam Gene Tree for IL1R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL1R1 gene
    IL1R22  IL1RL22  IL1RAPL22  IL1RAPL12  IL1RL12  IL1RAP2  IL18RAP2  IL18R12  
    3 SIMAP similar genes for IL1R1 using alignment to 13 protein entries:     IL1R1_HUMAN (see all proteins):
    IL1RL1    IL1RL2    IL1R2

    IL1R1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/893 SNPs in IL1R1 are shown (see all 893)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443139501,2
    --102768406(+) GGGGGC/TGCTGA 1 -- us2k10--------
    rs782578751,2
    C,F--102768442(+) GGGGCC/TGATGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1164551931,2
    C,F--102768652(+) AAAAGG/AAGGGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs101838691,2
    C,F,A,H--102768658(+) AGGGAA/GAATGA 1 -- us2k1 trp35Minor allele frequency- G:0.19NA WA EA 362
    rs101947161,2
    C,F,A,H--102768689(+) GGCCAG/AGTGCA 1 -- us2k16Minor allele frequency- A:0.29WA NA EA 364
    rs1864925241,2
    C--102768761(+) GAGATC/GGAGAC 1 -- us2k10--------
    rs19783301,2
    C,F--102768855(-) cctgaG/Atagct 1 -- us2k14Minor allele frequency- A:0.38NA WA 8
    rs362147841,2
    C--102768919(+) TAGATC/TGCACC 1 -- us2k10--------
    rs362147851,2
    C--102768960(+) ACTCCA/GTCTCA 1 -- us2k10--------
    rs1143472811,2
    C--102769036(+) AGAAGC/TTTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL1R1 (102681004 - 102796334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL1R1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv874734CNV Loss21882294


    Human Gene Mutation Database (HGMD): IL1R1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1R1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147810    OMIM disorders: --

    20/207 diseases for IL1R1 (see all 207):    About MalaCards
    schnitzler syndrome    raynaud disease    adult-onset still's disease    cryopyrin-associated periodic syndrome
    graft versus host disease    wells syndrome    aseptic meningitis    shigellosis
    papilledema    rheumatic disease    muckle-wells syndrome    alopecia areata
    vulvar vestibulitis syndrome    subacute thyroiditis    intrauterine infections    chronic infantile neurological cutaneous articular syndrome
    paratyphoid fever    periventricular leukomalacia    familial cold autoinflammatory syndrome    post-transplant lymphoproliferative disease


    IL1R1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for IL1R1 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 77.2 404 8225219 (5), 7897303 (4), 8808459 (4), 9065108 (3) (see all 99)
    inflammation 70.7 92 7584121 (2), 17888220 (2), 16009838 (2), 1834697 (2) (see all 71)
    schnitzler syndrome 66.5 4 16096327 (1), 20064173 (1), 18371052 (1), 18480937 (1)
    rheumatoid arthritis 66 92 15201943 (2), 8670316 (2), 7748221 (2), 15225683 (2) (see all 66)
    cinca syndrome 63.8 1 16532456 (1)
    muckle-wells syndrome 57.7 3 16014694 (1), 12815153 (1), 16531551 (1)
    tumors 54.9 316 8225219 (5), 7897303 (4), 8808459 (4), 9065108 (3) (see all 99)
    arthritis 54.5 22 8006890 (4), 20028520 (2), 10088773 (2), 17947302 (1) (see all 12)
    cold hypersensitivity 51 2 17336710 (1), 15541451 (1)
    systemic inflammatory response syndrome 50.4 20 1834697 (3), 8124953 (2), 7611862 (2), 9386664 (2) (see all 10)

    Genetic Association Database (GAD): IL1R1
    Human Genome Epidemiology (HuGE) Navigator: IL1R1 (157 documents)

    Export disorders for IL1R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1R1 gene, integrated from 9 sources (see all 1389):
    (articles sorted by number of sources associating them with IL1R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort. (PubMed id 17083033)1, 4, 7, 9 Do H....Zagury J.F. (2006)
    2. X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. (PubMed id 10903327)1, 2, 9 Vigers G.P.A.... Brandhuber B.J. (2000)
    3. Graves' ophthalmopathy and gene polymorphisms in inte rleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 rec eptor antagonist. (PubMed id 19702713)1, 4, 9 Khalilzadeh O....Amirzargar A. (2009)
    4. Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. (PubMed id 9062193)1, 2, 9 Vigers G.P.A.... Brandhuber B.J. (1997)
    5. FokI polymorphism, vitamin D receptor, and interleukin-1 receptor haplotypes are associated with type 1 diabetes in the Dalmatian population. (PubMed id 16258158)1, 4, 9 Zemunik T....Terzic J. (2005)
    6. Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men. (PubMed id 15797878)1, 4, 9 Pastor I.J....Gonzalez-Sarmiento R. (2005)
    7. Association of single nucleotide polymorphisms within cytokine genes with juvenile idiopathic arthritis in the Czech population. (PubMed id 15170937)1, 4, 9 Cinek O....Slavcev A. (2004)
    8. [The association between interleukin-1 receptor antagonist genotype and chronic periodontitis of Uighur patients] (PubMed id 14680589)1, 4, 9 Zhong L.J....Yang A.L. (2003)
    9. Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in post-menopausal Mediterranean women. (PubMed id 12240899)1, 4, 9 Fontova R....Richart C. (2002)
    10. Polymorphism of the cytokine genes and IgA nephropathy. (PubMed id 11849463)1, 4, 9 Syrjanen J....Pasternack A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3554 HGNC: 5993 AceView: IL1R1 Ensembl:ENSG00000115594 euGenes: HUgn3554
    ECgene: IL1R1 Kegg: 3554 H-InvDB: IL1R1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1R1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il1r1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL1R1 gene:
    Search GeneIP for patents involving IL1R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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