Aliases for IL1F10 Gene
External Ids for IL1F10 Gene
Previous GeneCards Identifiers for IL1F10 Gene
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1F10 Gene
IL1F10 (Interleukin 1 Family Member 10 (Theta)) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1RN.
UniProtKB/Swiss-Prot for IL1F10 Gene
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.