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Aliases for IL1F10 Gene

Aliases for IL1F10 Gene

  • Interleukin 1 Family Member 10 (Theta) 2 3 5
  • Interleukin-1 Receptor Antagonist FKSG75 2 3
  • Interleukin 1 Family, Member 10 (Theta) 2 3
  • Family Of Interleukin 1-Theta 3 4
  • Interleukin-1 HY2 3 4
  • Interleukin-38 3 4
  • FIL1 Theta 3 4
  • IL-1 Theta 3 4
  • IL-1HY2 3 4
  • IL1HY2 3 4
  • IL-38 3 4
  • Interleukin-1 Receptor Antagonist-Like FIL1 Theta 3
  • IL-1F10 (Canonical Form IL-1F10a) 3
  • Interleukin-1 Theta 4
  • FIL1- Theta 2
  • FIL1-Theta 3
  • IL1-Theta 3
  • IL-1F10 4
  • FKSG75 3
  • FIL1T 4
  • IL38 4

External Ids for IL1F10 Gene

Previous GeneCards Identifiers for IL1F10 Gene

  • GC02P111031
  • GC02P111746
  • GC02P113732
  • GC02P113920
  • GC02P113541
  • GC02P113825
  • GC02P106280

Summaries for IL1F10 Gene

Entrez Gene Summary for IL1F10 Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1F10 Gene

IL1F10 (Interleukin 1 Family Member 10 (Theta)) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1RN.

UniProtKB/Swiss-Prot for IL1F10 Gene

  • Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.

Gene Wiki entry for IL1F10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1F10 Gene

Genomics for IL1F10 Gene

Regulatory Elements for IL1F10 Gene

Enhancers for IL1F10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL1F10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL1F10 gene promoter:

Genomic Location for IL1F10 Gene

Chromosome:
2
Start:
113,067,970 bp from pter
End:
113,075,850 bp from pter
Size:
7,881 bases
Orientation:
Plus strand

Genomic View for IL1F10 Gene

Genes around IL1F10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1F10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1F10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1F10 Gene

Proteins for IL1F10 Gene

  • Protein details for IL1F10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWZ1-IL1FA_HUMAN
    Recommended name:
    Interleukin-1 family member 10
    Protein Accession:
    Q8WWZ1
    Secondary Accessions:
    • Q53SR9
    • Q56AT8
    • Q7RTZ5
    • Q969H5
    • Q9BYX1

    Protein attributes for IL1F10 Gene

    Size:
    152 amino acids
    Molecular mass:
    16943 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL1F10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1F10 Gene

Proteomics data for IL1F10 Gene at MOPED

Post-translational modifications for IL1F10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL1F10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL1F10 (IL-38/IL-1F10)
  • Cloud-Clone Corp. Antibodies for IL1F10

No data available for DME Specific Peptides for IL1F10 Gene

Domains & Families for IL1F10 Gene

Gene Families for IL1F10 Gene

Protein Domains for IL1F10 Gene

Suggested Antigen Peptide Sequences for IL1F10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWZ1

UniProtKB/Swiss-Prot:

IL1FA_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL1F10: view

Function for IL1F10 Gene

Molecular function for IL1F10 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
genes like me logo Genes that share phenotypes with IL1F10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL1F10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL1F10 Gene

Localization for IL1F10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1F10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1F10 Gene COMPARTMENTS Subcellular localization image for IL1F10 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for IL1F10 Gene

Pathways & Interactions for IL1F10 Gene

genes like me logo Genes that share pathways with IL1F10: view

Pathways by source for IL1F10 Gene

1 R&D Systems pathway for IL1F10 Gene

Interacting Proteins for IL1F10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341794%0d%0a9606.ENSP00000233946%0d%0a
Selected Interacting proteins: ENSP00000341794 Q8WWZ1-IL1FA_HUMAN for IL1F10 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IL1F10 Gene

None

No data available for SIGNOR curated interactions for IL1F10 Gene

Drugs & Compounds for IL1F10 Gene

No Compound Related Data Available

Transcripts for IL1F10 Gene

mRNA/cDNA for IL1F10 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1F10 Gene

Interleukin 1 family, member 10 (theta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1F10 Gene

No ASD Table

Relevant External Links for IL1F10 Gene

GeneLoc Exon Structure for
IL1F10
ECgene alternative splicing isoforms for
IL1F10

Expression for IL1F10 Gene

mRNA expression in normal human tissues for IL1F10 Gene

mRNA differential expression in normal tissues according to GTEx for IL1F10 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.3) and Skin - Not Sun Exposed (Suprapubic) (x24.9).

Protein differential expression in normal tissues from HIPED for IL1F10 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1F10 Gene



SOURCE GeneReport for Unigene cluster for IL1F10 Gene Hs.306974

mRNA Expression by UniProt/SwissProt for IL1F10 Gene

Q8WWZ1-IL1FA_HUMAN
Tissue specificity: Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
genes like me logo Genes that share expression patterns with IL1F10: view

Protein tissue co-expression partners for IL1F10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL1F10 Gene

Orthologs for IL1F10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL1F10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL1F10 35
  • 85.87 (n)
  • 86.09 (a)
IL1F10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1F10 35
  • 84.56 (n)
  • 83.89 (a)
IL1F10 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1f10 35
  • 82.34 (n)
  • 82.12 (a)
Il1f10 16
Il1f10 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1F10 35
  • 99.12 (n)
  • 98.03 (a)
IL1F10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1f10 35
  • 83.22 (n)
  • 82.78 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1F10 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1F10 36
  • 68 (a)
OneToOne
Species with no ortholog for IL1F10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1F10 Gene

ENSEMBL:
Gene Tree for IL1F10 (if available)
TreeFam:
Gene Tree for IL1F10 (if available)

Paralogs for IL1F10 Gene

Paralogs for IL1F10 Gene

(3) SIMAP similar genes for IL1F10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL1F10: view

Variants for IL1F10 Gene

Sequence variations from dbSNP and Humsavar for IL1F10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6761276 - 113,074,735(+) CTGCA(C/T)ACTTC reference, missense
rs6743376 - 113,074,756(+) CTTGG(A/C)CCGCA reference, missense
rs921065 -- 113,068,389(+) CTTTG(C/T)AGGCA intron-variant
rs1867832 -- 113,069,250(+) CCAGA(C/T)GGTGA intron-variant
rs1867833 -- 113,069,255(+) CGGTG(A/G)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1F10 Gene

Variant ID Type Subtype PubMed ID
nsv2881 CNV Loss 18451855
nsv874894 CNV Loss 21882294

Variation tolerance for IL1F10 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL1F10 Gene

Disorders for IL1F10 Gene

Relevant External Links for IL1F10

Genetic Association Database (GAD)
IL1F10
Human Genome Epidemiology (HuGE) Navigator
IL1F10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1F10

No disorders were found for IL1F10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL1F10 Gene

Publications for IL1F10 Gene

  1. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. (PMID: 11747621) Bensen J.T. … Bowden D.W. (J. Interferon Cytokine Res. 2001) 2 3 4 23 67
  2. The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis. (PMID: 20141484) Jung M.Y. … Chung J.H. (Scand. J. Rheumatol. 2010) 3 23
  3. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PMID: 11991722) Nicklin M.J.H. … Kornman K. (Genomics 2002) 2 3
  4. Genomic organization of the interleukin-1 locus. (PMID: 11991723) Taylor S.L. … Sims J.E. (Genomics 2002) 2 3
  5. Cloning and characterization of IL1HY2, a novel interleukin-1 family member. (PMID: 11278614) Lin H. … Ford J.E. (J. Biol. Chem. 2001) 3 23

Products for IL1F10 Gene

  • Cloud-Clone Corp. Antibodies for IL1F10
  • Cloud-Clone Corp. Proteins for IL1F10
  • Cloud-Clone Corp Assay Kits for IL1F10

Sources for IL1F10 Gene

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