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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1F10 Gene

protein-coding   GIFtS: 51
GCID: GC02P113825

Interleukin 1 Family, Member 10 (Theta)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 1 Family, Member 10 (Theta)1 2     IL-382
Interleukin-1 Receptor Antagonist FKSG751 2     IL1-theta2
Interleukin-1 HY22 3     IL-1F10 (Canonical Form IL-1F10a)2
IL-1HY22 3     Interleukin-1 Family Member 102
IL1HY22 3     Interleukin-1 Receptor Antagonist-Like FIL1 Theta2
FIL1 Theta2 3     FIL1T3
IL-1 Theta2 3     IL-1F103
FIL1- Theta1     Interleukin-1 Theta3
FIL1-theta2     

External Ids:    HGNC: 155521   Entrez Gene: 846392   Ensembl: ENSG000001366977   OMIM: 6152965   UniProtKB: Q8WWZ13   

Export aliases for IL1F10 gene to outside databases

Previous GC identifers: GC02P111031 GC02P111746 GC02P113732 GC02P113920 GC02P113541 GC02P106280


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1F10 Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other
interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate
in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively
spliced transcript variants encoding the same protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1F10 Gene: 
IL1F10 (interleukin 1 family, member 10 (theta)) is a protein-coding gene. Diseases associated with IL1F10 include ankylosing spondylitis, and tonsillitis. GO annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1
Function: Binds soluble IL-1 receptor type 1

Gene Wiki entry for IL1F10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1F10 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL1F10 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1F10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1F10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

IL1F10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1F10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113825:  view genomic region     (about GC identifiers)

Start:
113,825,547 bp from pter      End:
113,833,427 bp from pter
Size:
7,881 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1 (See protein sequence)
Recommended Name: Interleukin-1 family member 10  
Size: 152 amino acids; 16943 Da
Subcellular location: Secreted
Secondary accessions: Q53SR9 Q56AT8 Q7RTZ5 Q969H5 Q9BYX1
Alternative splicing: 2 isoforms:  Q8WWZ1-1   Q8WWZ1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL1F10: NX_Q8WWZ1

Explore proteomics data for IL1F10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWZ1

  • IL1F10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL1F10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_115945.4  NP_775184.1  

    ENSEMBL proteins: 
     ENSP00000341794   ENSP00000376893   ENSP00000338418  

    Human Recombinant Protein Products for IL1F10: 
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    Novus Biologicals IL1F10 Protein
    Novus Biologicals IL1F10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL1F10
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    IL1F10 for ontologies           About GeneDecksing



    IL1F10 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR003297 IL-1RA/IL-36
     IPR000975 Interleukin_1
     IPR008996 Cytokine_IL1-like
     IPR027164 IL-1F10

    Graphical View of Domain Structure for InterPro Entry Q8WWZ1

    ProtoNet protein and cluster: Q8WWZ1

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1
    Similarity: Belongs to the IL-1 family


    IL1F10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1FA_HUMAN, Q8WWZ1
    Function: Binds soluble IL-1 receptor type 1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding IEA--
         
    IL1F10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL1F10:
     Decreased POU5F1-GFP protein e 

         1 MGI phenotypic allele for Il1f10 (no phenotypes)

    IL1F10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il1f10tm1Lex for IL1F10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL1F10 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL1F10:
    hsa-miR-345
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1F10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1F10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IL1F10 (Q8WWZ13 ENSP000003417944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1R1P147783, ENSP000002339464I2D: score=1 STRING: ENSP00000233946
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response ----
    GO:0006955immune response ----

    IL1F10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL1F10 (IL1FA)

    Search CenterWatch for drugs/clinical trials and news about IL1F10 / IL1FA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL1F10 gene (2 alternative transcripts): 
    NM_032556.5  NM_173161.2  

    Unigene Cluster for IL1F10:

    Interleukin 1 family, member 10 (theta)
    Hs.306974  [show with all ESTs]
    Unigene Representative Sequence: AF334755
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341010(uc002tiu.3) ENST00000393197(uc002tiv.3) ENST00000496265
    ENST00000337569(uc002tiw.3)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL1F10:
    hsa-miR-345
    SwitchGear 3'UTR luciferase reporter plasmidIL1F10 3' UTR sequence
    Inhib. RNA
    Products:
         
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                         Customized lentivirus expression plasmids for stable overexpression of IL1F10 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1F10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1F10

    Additional mRNA sequence: 

    AF334755.1 AY026753.1 AY029413.1 AY358846.1 BC103966.1 BC103967.1 BC103968.1 

    3 DOTS entries:

    DT.97790256  DT.97797914  DT.91851377 

    15 AceView cDNA sequences:

    AY358846 NM_032556 NM_173161 AY029413 AY026753 CA309648 AF334755 CD634100 
    CD634102 CD634092 CD634094 CD634104 CD634090 CD634098 CD634096 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1F10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTCAGCT
    IL1F10 Expression
    About this image


    See IL1F10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL1F10

    SOURCE GeneReport for Unigene cluster: Hs.306974

    UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1
    Tissue specificity: Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin
    and in proliferating B-cells of the tonsil

        SABiosciences Expression via Pathway-Focused PCR Array including IL1F10: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1F10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL1F10 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1f101 , 5 interleukin 1 family, member 101, 5 82.34(n)1
    82.12(a)1
      2 (16.32 cM)5
    2152741  NM_153077.21  NP_694717.11 
     242911965 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    33(a)
    31(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343238.1(853473-859585)
    GL343238.1(908975-910584)


    ENSEMBL Gene Tree for IL1F10 (if available)
    TreeFam Gene Tree for IL1F10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL1F10 gene
    IL36A2  IL36B2  IL372  IL1RN2  IL36RN2  IL36G2  
    3 SIMAP similar genes for IL1F10 using alignment to 2 protein entries:     IL1FA_HUMAN (see all proteins):
    IL36RN    IL1RN    IL36A

    IL1F10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/285 SNPs in IL1F10 are shown (see all 285)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118981581,2
    C,F,H--113823572(+) AAAAAA/GGCAAT 1 -- us2k125Minor allele frequency- G:0.08NS EA NA WA CSA 2462
    rs790046661,2
    C,F--113823601(+) AAGCAC/GTTAAA 1 -- us2k13Minor allele frequency- G:0.09WA NA EA 358
    rs124751611,2
    C,F,A,H--113823626(+) AAGAAC/TGTGCT 1 -- us2k117Minor allele frequency- T:0.36NS EA NA WA CSA 791
    rs2018757691,2
    C--113823671(+) CAATGG/TGTGCA 1 -- us2k10--------
    rs729467371,2
    C,F--113823746(+) GATAGG/TGTTTC 1 -- us2k14Minor allele frequency- T:0.17WA NA EA 360
    rs1463365961,2
    --113823798(+) CAGAGC/TCTAAT 1 -- us2k10--------
    rs1123403821,2
    C,F--113823916(+) AGTGGG/TGCCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1883937811,2
    --113824021(+) TGGCTA/GATTTT 1 -- us2k10--------
    rs289924961,2
    C,F--113824092(+) TCAAGG/TGATCT 1 -- us2k14Minor allele frequency- T:0.15NS WA NA 214
    rs778881051,2
    C--113824175(+) TTTTT-/TGCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL1F10 (113825547 - 113833427 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL1F10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv874894CNV Loss21882294
    nsv2881CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1F10
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1F10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615296    OMIM disorders: --

    9 diseases for IL1F10:    About MalaCards
    ankylosing spondylitis    tonsillitis    spondylitis    ulcerative colitis
    hepatitis b    rheumatoid arthritis    myocardial infarction    arthritis
    hepatitis


    IL1F10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IL1F10
    Human Genome Epidemiology (HuGE) Navigator: IL1F10 (15 documents)

    Export disorders for IL1F10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1F10 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with IL1F10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. (PubMed id 11747621)1, 2, 3, 9 Bensen J.T.... Bowden D.W. (2001)
    2. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2, 3 Nicklin M.J.H....Kornman K. (2002)
    3. Genomic organization of the interleukin-1 locus. (PubMed id 11991723)1, 2, 3 Taylor S.L....Sims J.E. (2002)
    4. Cloning and characterization of IL1HY2, a novel interleukin-1 family member. (PubMed id 11278614)1, 2, 9 Lin H.... Ford J.E. (2001)
    5. The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis. (PubMed id 20141484)1, 4, 9 Jung M.Y....Chung J.H. (2010)
    6. Meta-analysis of genome-wide association studies in & gt;80 000 subjects identifies multiple loci for C-reactive protein levels. (PubMed id 21300955)1, 4 Dehghan A....Chasman D.I. (2011)
    7. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    10. Interleukin 1 Polymorphisms in Patients with Ankylosing Spondylitis in Korea. (PubMed id 18484691)1, 4 Kim T.J....Inman R.D. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84639 HGNC: 15552 AceView: IL1F10 Ensembl:ENSG00000136697 euGenes: HUgn84639
    ECgene: IL1F10 H-InvDB: IL1F10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1F10 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL1F10 gene:
    Search GeneIP for patents involving IL1F10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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