Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IL1F10 Gene

protein-coding   GIFtS: 51
GCID: GC02P113825

Interleukin 1 Family, Member 10 (Theta)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Interleukin 1 Family, Member 10 (Theta)1 2     IL1-theta2
IL1HY22 3 5     IL-1F10 (Canonical Form IL-1F10a)2
Interleukin-1 Receptor Antagonist FKSG751 2     Interleukin-1 Family Member 102
Family Of Interleukin 1-Theta2 3     Interleukin-1 Receptor Antagonist-Like FIL1 Theta2
Interleukin-1 HY22 3     interleukin-382
IL-1HY22 3     FIL1T3
IL-382 3     IL-1F103
FIL1 Theta2 3     IL383
IL-1 Theta2 3     Interleukin-383
FIL1- Theta1     Interleukin-1 Theta3
FIL1-theta2     

External Ids:    HGNC: 155521   Entrez Gene: 846392   Ensembl: ENSG000001366977   OMIM: 6152965   UniProtKB: Q8WWZ13   

Export aliases for IL1F10 gene to outside databases

Previous GC identifers: GC02P111031 GC02P111746 GC02P113732 GC02P113920 GC02P113541 GC02P106280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IL1F10 Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other
interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate
in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively
spliced transcript variants encoding the same protein have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1F10 Gene:
IL1F10 (interleukin 1 family, member 10 (theta)) is a protein-coding gene. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity. An important paralog of this gene is IL36A.

UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1
Function: Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22
and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of
IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial
lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2

Gene Wiki entry for IL1F10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1F10 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL1F10 promoter sequence
   Search Chromatin IP Primers for IL1F10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1F10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

IL1F10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1F10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113825:  view genomic region     (about GC identifiers)

Start:
113,825,547 bp from pter      End:
113,833,427 bp from pter
Size:
7,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1 (See protein sequence)
Recommended Name: Interleukin-1 family member 10  
Size: 152 amino acids; 16943 Da
Secondary accessions: Q53SR9 Q56AT8 Q7RTZ5 Q969H5 Q9BYX1
Alternative splicing: 2 isoforms:  Q8WWZ1-1   Q8WWZ1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL1F10: NX_Q8WWZ1

Explore proteomics data for IL1F10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IL1F10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_115945.4  NP_775184.1  

    ENSEMBL proteins: 
     ENSP00000341794   ENSP00000376893   ENSP00000338418  

    IL1F10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL1F10
    OriGene Protein Over-expression Lysate for IL1F10
    OriGene MassSpec for IL1F10
    OriGene Custom Protein Services for IL1F10
    GenScript Custom Purified and Recombinant Proteins Services for IL1F10
    Novus Biologicals IL1F10 Protein
    Novus Biologicals IL1F10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL1F10
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IL1F10 

     
    antibodies-online proteins for IL1F10 (16 products) 

     
    antibodies-online peptides for IL1F10

    IL1F10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL1F10 (IL-38/IL-1F10)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IL1F10
    Novus Biologicals IL1F10 Antibodies
    Search for Antibodies for IL1F10 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for IL1F10
    antibodies-online antibodies for IL1F10 (9 products) 

    IL1F10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL1F10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IL1F10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IL1F10 
    antibodies-online kits for IL1F10 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR003297 IL-1RA/IL-36
     IPR000975 IL-1
     IPR008996 Cytokine_IL1-like
     IPR027164 IL-1_F10

    Graphical View of Domain Structure for InterPro Entry Q8WWZ1

    ProtoNet protein and cluster: Q8WWZ1

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1
    Similarity: Belongs to the IL-1 family


    Find genes that share domains with IL1F10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1FA_HUMAN, Q8WWZ1
    Function: Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22
    and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of
    IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial
    lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005149interleukin-1 receptor binding IEA--
         
    Find genes that share ontologies with IL1F10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL1F10:
     Decreased POU5F1-GFP protein e 

         1 MGI phenotypic allele for Il1f10 (no phenotypes)

    Find genes that share phenotypes with IL1F10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il1f10tm1Lex for IL1F10

       genOway: Develop your customized and physiologically relevant rodent model for IL1F10

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL1F10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL1F10:
    hsa-miR-345
    SwitchGear 3'UTR luciferase reporter plasmidIL1F10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL1F10
    Predesigned siRNA for gene silencing in human, mouse, rat IL1F10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL1F10

    Clone
    Products:
         
    OriGene clones in human, mouse for IL1F10 (see all 11)
    OriGene ORF clones in mouse, rat for IL1F10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL1F10 (NM_173161)
    Sino Biological Human cDNA Clone for IL1F10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1F10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1F10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL1F10
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL1F10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1F10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IL1FA_HUMAN, Q8WWZ1: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL1F10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IL1F10 About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL1F10
        IL-1 Family Signaling Pathways




        Pathway & Disease-focused RT2 Profiler PCR Array including IL1F10: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL1F10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IL1F10 (Q8WWZ13 ENSP000003417944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1R1P147783, ENSP000002339464I2D: score=1 STRING: ENSP00000233946
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response ----
    GO:0006955immune response ----

    Find genes that share ontologies with IL1F10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL1F10 (IL1FA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IL1F10 gene (2 alternative transcripts): 
    NM_032556.5  NM_173161.2  

    Unigene Cluster for IL1F10:

    Interleukin 1 family, member 10 (theta)
    Hs.306974  [show with all ESTs]
    Unigene Representative Sequence: AF334755
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341010(uc002tiu.3) ENST00000393197(uc002tiv.3) ENST00000496265
    ENST00000337569(uc002tiw.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL1F10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL1F10:
    hsa-miR-345
    SwitchGear 3'UTR luciferase reporter plasmidIL1F10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL1F10
    Predesigned siRNA for gene silencing in human, mouse, rat IL1F10
    Clone
    Products:
         
    OriGene clones in human, mouse for IL1F10 (see all 11)
    OriGene ORF clones in mouse, rat for IL1F10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL1F10 (NM_173161)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1F10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1F10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IL1F10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL1F10
      QuantiTect SYBR Green Assays in human, mouse, rat IL1F10
      QuantiFast Probe-based Assays in human, mouse, rat IL1F10

    Additional mRNA sequence: 

    AF334755.1 AY026753.1 AY029413.1 AY358846.1 BC103966.1 BC103967.1 BC103968.1 

    3 DOTS entries:

    DT.97790256  DT.97797914  DT.91851377 

    15 AceView cDNA sequences:

    NM_173161 AY358846 AY029413 AY026753 NM_032556 AF334755 CA309648 CD634096 
    CD634100 CD634094 CD634104 CD634090 CD634102 CD634092 CD634098 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IL1F10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTCAGCT
    IL1F10 Expression
    About this image

    IL1F10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL1F10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306974

    UniProtKB/Swiss-Prot: IL1FA_HUMAN, Q8WWZ1
    Tissue specificity: Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin
    and in proliferating B-cells of the tonsil

        Pathway & Disease-focused RT2 Profiler PCR Array including IL1F10: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IL1F10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL1F10
    QuantiTect SYBR Green Assays in human, mouse, rat IL1F10
    QuantiFast Probe-based Assays in human, mouse, rat IL1F10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1F10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL1F10 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1f101 , 5 interleukin 1 family, member 101, 5 82.34(n)1
    82.12(a)1
      2 (16.32 cM)5
    2152741  NM_153077.21  NP_694717.11 
     242911965 


    ENSEMBL Gene Tree for IL1F10 (if available)
    TreeFam Gene Tree for IL1F10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IL1F10 gene
    IL36A2  IL36B2  IL372  IL1RN2  IL36RN2  IL36G2  
    3 SIMAP similar genes for IL1F10 using alignment to 2 protein entries:     IL1FA_HUMAN (see all proteins):
    IL36RN    IL1RN    IL36A

    Find genes that share paralogs with IL1F10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IL1F10 (see all 285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118981581,2
    C,F,H--113823572(+) AAAAAA/GGCAAT 1 -- us2k125Minor allele frequency- G:0.08NS EA NA WA CSA 2462
    rs790046661,2
    C,F--113823601(+) AAGCAC/GTTAAA 1 -- us2k13Minor allele frequency- G:0.09WA NA EA 358
    rs124751611,2
    C,F,A,H--113823626(+) AAGAAC/TGTGCT 1 -- us2k117Minor allele frequency- T:0.36NS EA NA WA CSA 791
    rs2018757691,2
    C--113823671(+) CAATGG/TGTGCA 1 -- us2k10--------
    rs729467371,2
    C,F--113823746(+) GATAGG/TGTTTC 1 -- us2k14Minor allele frequency- T:0.17WA NA EA 360
    rs1463365961,2
    --113823798(+) CAGAGC/TCTAAT 1 -- us2k10--------
    rs1123403821,2
    C,F--113823916(+) AGTGGG/TGCCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1883937811,2
    --113824021(+) TGGCTA/GATTTT 1 -- us2k10--------
    rs289924961,2
    C,F--113824092(+) TCAAGG/TGATCT 1 -- us2k14Minor allele frequency- T:0.15NS WA NA 214
    rs778881051,2
    C--113824175(+) TTTTT-/TGCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL1F10 (113825547 - 113833427 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL1F10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874894CNV Loss21882294
    nsv2881CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1F10
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1F10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615296    OMIM disorders: --


    Find genes that share disorders with IL1F10           About GenesLikeMe

    Genetic Association Database (GAD): IL1F10
    Human Genome Epidemiology (HuGE) Navigator: IL1F10 (15 documents)

    Export disorders for IL1F10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IL1F10 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with IL1F10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. (PubMed id 11747621)1, 2, 3, 9 Bensen J.T.... Bowden D.W. (J. Interferon Cytokine Res. 2001)
    2. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PubMed id 11991722)1, 2, 3 Nicklin M.J.H....Kornman K. (Genomics 2002)
    3. Genomic organization of the interleukin-1 locus. (PubMed id 11991723)1, 2, 3 Taylor S.L.... Sims J.E. (Genomics 2002)
    4. Cloning and characterization of IL1HY2, a novel interleukin-1 family member. (PubMed id 11278614)1, 2, 9 Lin H.... Ford J.E. (J. Biol. Chem. 2001)
    5. The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis. (PubMed id 20141484)1, 4, 9 Jung M.Y....Chung J.H. (Scand. J. Rheumatol. 2010)
    6. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. (PubMed id 22315422)1, 2 van de Veerdonk F.L....Dinarello C.A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels. (PubMed id 21300955)1, 4 Dehghan A....Chasman D.I. (Circulation 2011)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84639 HGNC: 15552 AceView: IL1F10 Ensembl:ENSG00000136697 euGenes: HUgn84639
    ECgene: IL1F10 H-InvDB: IL1F10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IL1F10 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1f10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IL1F10 gene:
    Search GeneIP for patents involving IL1F10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for IL1F10 (IL-38/IL-1F10)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IL1F10  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IL1F10  
     OriGene MassSpec for IL1F10   OriGene clones in human, mouse for IL1F10  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL1F10   OriGene Purified Protein for IL1F10  
     OriGene ORF clones in mouse, rat for IL1F10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL1F10   OriGene Custom Protein Services for IL1F10  

     
     
     Block miRNA regulation of human, mouse, rat IL1F10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IL1F10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1F10 Predesigned siRNA for gene silencing in human, mouse, rat IL1F10
     QuantiFast Probe-based Assays in human, mouse, rat IL1F10 QuantiTect SYBR Green Assays in human, mouse, rat IL1F10
     PCR Arrays including human, mouse, rat IL1F10 Search Chromatin IP Primers for IL1F10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL1F10  GeneGlobe Interaction Network for IL1F10
     Regulatory tfbs in IL1F10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IL1F10 GenScript cDNA clones with any tag delivered in your preferred vector for IL1F10
     GenScript Custom Assay Services for IL1F10 GenScript Custom overexpressing Cell Line Services for IL1F10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IL1F10 (IL1FA)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IL1F10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IL1F10 antibodies
     IL1F10 proteins
     IL1F10 lysates
     Search for Antibodies for IL1F10 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for IL1F10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IL1F10
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IL1F10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1F10
     SwitchGear 3'UTR luciferase reporter plasmids for IL1F10
     SwitchGear Promoter luciferase reporter plasmids for IL1F10
     Search ThermoFisher Antibodies for IL1F10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1F10
     Browse compounds at ApexBio
     Search Addgene for plasmids for IL1F10
      Search eBioscience for proteins for IL1F10
      Search eBioscience for elisas for IL1F10
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for IL1F10
     antibodies-online antibodies for IL1F10 (9 products)
     antibodies-online kits for IL1F10 (4 products)
     antibodies-online peptides for IL1F10
     antibodies-online proteins for IL1F10 (16 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL1F10 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4