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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL1B Gene

protein-coding   GIFtS: 69
GCID: GC02M113587

Interleukin 1, Beta

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 1, Beta1 2     catabolin2
IL1F22 3     Interleukin-1 Beta2
IL-1 Beta2 3     Preinterleukin 1 Beta2
IL-12     pro-interleukin-1-beta2
IL1-BETA2     Catabolin3

External Ids:    HGNC: 59921   Entrez Gene: 35532   Ensembl: ENSG000001255387   OMIM: 1477205   UniProtKB: P015843   

Export aliases for IL1B gene to outside databases

Previous GC identifers: GC02M110793 GC02M111508 GC02M113494 GC02M113682 GC02M113303 GC02M106041


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1B Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by
activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1
(CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of
cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of
cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to
inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene
cluster on chromosome 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1B Gene: 
IL1B (interleukin 1, beta) is a protein-coding gene. Diseases associated with IL1B include benign migratory glossitis, and central nervous system leukemia, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and IL-1 beta-dependent CFTR expression. GO annotations related to this gene include cytokine activity and protein domain specific binding.

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release,
B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the
inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of
prostaglandin and collagenase from synovial cells

summary for IL1B Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL1B gene promoter:
         COUP-TF1   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   STAT3   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL1B promoter sequence
   Search SABiosciences Chromatin IP Primers for IL1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14

IL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M113587:  view genomic region     (about GC identifiers)

Start:
113,587,328 bp from pter      End:
113,594,480 bp from pter
Size:
7,153 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584 (See protein sequence)
Recommended Name: Interleukin-1 beta precursor  
Size: 269 amino acids; 30748 Da
Subunit: Monomer
Subcellular location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests
that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory
proteins
6/30 PDB 3D structures from and Proteopedia for IL1B (see all 30):
1HIB (3D)        1I1B (3D)        1IOB (3D)        1ITB (3D)        1L2H (3D)        1S0L (3D)    
Secondary accessions: Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6

Explore the universe of human proteins at neXtProt for IL1B: NX_P01584

Explore proteomics data for IL1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01584

  • IL1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL1B Protein Expression
    REFSEQ proteins: NP_000567.1  
    ENSEMBL proteins: 
     ENSP00000263341   ENSP00000407219   ENSP00000409680   ENSP00000400854  
    Reactome Protein details: P01584
    Human Recombinant Protein Products for IL1B: 
    EMD Millipore Purified and/or Recombinant IL1B Protein
    R&D Systems Recombinant & Natural Proteins for IL1B (IL-1 beta/IL-1F2)
    Enzo Life Sciences proteins for IL1B
    OriGene Purified Proteins for IL1B
    OriGene Protein Over-expression Lysate for IL1B
    OriGene MassSpec for IL1B 
    OriGene Custom Protein Services for IL1B
    GenScript Purified and Recombinant Proteins for IL1B
    Novus Biologicals IL1B Proteins
    Novus Biologicals IL1B Lysates
    Sino Biological Recombinant Protein for IL1B
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL1B
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IMP3493774
    GO:0005829cytosol TAS--
    GO:0030141secretory granule IEA--
    GO:0031982vesicle ----

    IL1B for ontologies           About GeneDecksing



    IL1B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL1B
    R&D Systems Antibodies for IL1B (IL-1 beta/IL-1F2)
    OriGene Antibodies for IL1B
    OriGene Custom Antibody Services for IL1B
    GenScript Superior Antibodies for IL1B
    Novus Biologicals IL1B Antibodies
    Abcam antibodies for IL1B
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for IL1B
    LSBio Antibodies in human, mouse, rat for IL1B 

    Assay Products for IL1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL1B
    R&D Systems Flow Cytometry Kits for IL1B (IL-1 beta/IL-1F2)         (see all)
    GenScript Custom Assay Services for IL1B
    Enzo Life Sciences assays for IL1B
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    5/7 InterPro protein domains (see all 7):
     IPR003502 IL1_propep
     IPR002348 IL1_HBGF
     IPR003296 InterleukinIL1B
     IPR000975 Interleukin_1
     IPR020877 Interleukin-1_CS

    Graphical View of Domain Structure for InterPro Entry P01584

    ProtoNet protein and cluster: P01584

    5 Blocks protein domains:
    IPB000975 Interleukin-1 precursor family signature
    IPB002348 IL1/HBGF family signature
    IPB003294 Interleukin-1 alpha/beta precursor family signature
    IPB003296 Interleukin-1 beta precursor signature
    IPB003502 Interleukin-1 propeptide


    UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584
    Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet
    undefined function
    Similarity: Belongs to the IL-1 family


    IL1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1B_HUMAN, P01584
    Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release,
    B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the
    inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of
    prostaglandin and collagenase from synovial cells

         Genatlas biochemistry entry for IL1B:
    interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively
    stimulating osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory
    response,susceptibility factor for inflammatory bowel diseaes

         Summary:
    IL1B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Mature dendritic-like cells from Blood, Macrophage-like cells from Blood

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IMP2989698
    GO:0005149interleukin-1 receptor binding NAS1919436
    GO:0008083growth factor activity ----
    GO:0019904protein domain specific binding IPI16575408
         
    IL1B for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il1b):
     cardiovascular system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     skeleton  tumorigenesis 

    IL1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL1B: Il1btm1Lvp Il1btm1Dch

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1B 

    miRNA
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    miRTarBase miRNAs that target IL1B:
    hsa-mir-204 (MIRT005830), hsa-mir-21 (MIRT005951)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1B
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1B:
    hsa-miR-205* hsa-miR-3121-3p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidIL1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL1B
    Sirion Biotech Customized adenovirus for overexpression of IL1B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL1B (see all 7)
    OriGene ORF clones in mouse, rat for IL1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL1B (NM_000576)
    Sino Biological Human cDNA Clone for IL1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1B
    Sirion Biotech Customized lentivirus for stable overexpression of IL1B 
                         Customized lentivirus expression plasmids for stable overexpression of IL1B 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL1B
    Search LifeMap BioReagents cell lines for IL1B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL1B About   (see all 65)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL-1 beta-dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    IL-1 Signaling Pathway0.32
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Non-alcoholic fatty liver disease (NAFLD)0.41
    Alzheimers Disease0.44
    4Toll Comparative Pathway
    Immune response MIF in innate immunity response0.46
    IL-1 Pathway0.39
    Immune response IL-1 signaling pathway0.41
    5Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for IL1B
        Transcription Role of VDR in regulation of genes involved in osteoporosis
    Selected targets of GCR-alpha
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway

    5/6 R&D Systems Pathways for IL1B (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Toll-Like receptor Signaling Pathways

    5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL1B (see all 38)
        14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for IL1B
        NF-kappaB Signaling

    3 Tocris Bioscience Pathways for IL1B
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for IL1B (see all 6)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Bacterial infections in CF airways
    IL-1 beta-dependent CFTR expression

    5/20 BioSystems Pathways for IL1B (see all 20)
        MAPK signaling pathway
    Myometrial Relaxation and Contraction Pathways
    NOD pathway
    Cytokines and Inflammatory Response
    Senescence and Autophagy


    5        Reactome Pathways for IL1B
        Interleukin-1 signaling
    Interleukin-1 processing
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    5/29         Kegg Pathways  (Kegg details for IL1B) (see all 29):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    NF-kappa B signaling pathway
    Apoptosis
    Osteoclast differentiation


    IL1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for IL1B (P015842, 3 ENSP000002633414) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL1R1P147782, 3, ENSP000002339464MINT-24831 I2D: score=8 STRING: ENSP00000233946
    IL1RAPQ9NPH33, ENSP000000725164I2D: score=3 STRING: ENSP00000072516
    ADRB2P075503, ENSP000003053724I2D: score=2 STRING: ENSP00000305372
    CASP4P496623, ENSP000003885664I2D: score=2 STRING: ENSP00000388566
    MAPK8IP2Q133873, ENSP000003305724I2D: score=1 STRING: ENSP00000330572
    About this table

    Gene Ontology (GO): 5/72 biological process terms (GO ID links to tree view) (see all 72):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0000187activation of MAPK activity IDA10748004
    GO:0001660fever generation IEA--
    GO:0001934positive regulation of protein phosphorylation NAS16477012
    GO:0002711positive regulation of T cell mediated immunity IC1919436

    IL1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for IL1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    4 DrugBank Compounds for IL1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Minocycline-- 10118-90-8targetmodulator11246672 8943052 9413935 12211491
    RilonaceptArcalyst (see all 2)501081-76-1targetbinder23553601 23319019
    CanakinumabACZ-885 (see all 2)914613-48-2targetbinder19169963
    Gallium nitrate-- 13494-90-1targetantagonist16122880

    10/136 Novoseek inferred chemical compound relationships for IL1B gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pge2 85.5 1669 15135319 (8), 19452719 (8), 17438251 (7), 1668251 (6) (see all 99)
    rantes 80.6 362 11600537 (6), 19080516 (6), 15499983 (6), 11063385 (5) (see all 99)
    endotoxin 78.9 487 15499983 (6), 9659298 (5), 10908988 (5), 15325407 (5) (see all 99)
    il 10 71.4 89 17022949 (3), 18832862 (3), 10645445 (2), 16842617 (2) (see all 63)
    dexamethasone 71.1 456 17513787 (6), 9758209 (5), 10657942 (5), 19435930 (4) (see all 99)
    nitric oxide 70.8 1245 10025918 (6), 1384465 (6), 11247871 (6), 9160463 (5) (see all 99)
    cycloheximide 69.4 155 1384465 (3), 1732280 (2), 9144567 (2), 1918980 (2) (see all 99)
    prostaglandin 69.1 243 1641502 (4), 8140125 (3), 9419743 (3), 9047011 (3) (see all 99)
    indomethacin 63.5 183 12639911 (4), 9627083 (4), 10772282 (4), 1348040 (4) (see all 99)
    sb 203580 63.3 64 12921636 (4), 18348730 (4), 17207362 (2), 20416175 (2) (see all 47)

    6 PharmGKB related drug/compound annotations for IL1B gene    About this table
    Drug/compound PharmGKB Annotation
    BisphosphonatesCA  
    aspirinCA  
    clodronateCA  
    etidronic acidCA  
    risedronateCA  
    tiludronateCA  

    Search CenterWatch for drugs/clinical trials and news about IL1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL1B gene: 
    NM_000576.2  

    Unigene Cluster for IL1B:

    Interleukin 1, beta
    Hs.126256  [show with all ESTs]
    Unigene Representative Sequence: AK313983
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263341(uc002tih.1 uc002tii.1) ENST00000491056 ENST00000487639
    ENST00000418817 ENST00000432018 ENST00000416750 ENST00000496280 ENST00000477398

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1B:
    hsa-miR-205* hsa-miR-3121-3p hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidIL1B 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1B
    Clone
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    OriGene clones in human, mouse for IL1B (see all 7)
    OriGene ORF clones in mouse, rat for IL1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL1B (NM_000576)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1B
    Sirion Biotech Customized lentivirus for stable overexpression of IL1B 
                         Customized lentivirus expression plasmids for stable overexpression of IL1B 
    Primer
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    OriGene qPCR primer pairs and template standards for IL1B
    OriGene qSTAR qPCR primer pairs in human, mouse for IL1B
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1B

    Additional mRNA sequence: 

    AB451494.1 AF043335.1 AK313983.1 BC008678.1 BT007213.1 CR407679.1 K02770.1 M15330.1 
    M54933.1 X02532.1 X56087.1 

    8 DOTS entries:

    DT.454455  DT.95307325  DT.101987199  DT.100026384  DT.121014363  DT.121014359  DT.95375716  DT.102824241 

    24/440 AceView cDNA sequences (see all 440):

    AA381823 AA381904 BI335905 BP336398 BP336474 BP335557 BP335812 AA381270 
    BP337190 BP336089 BP336360 AA381516 BP337935 BP336838 AA362191 BP336765 
    BQ000281 BP337042 BP336610 BP338851 CD370914 BP337833 X02532 CD240414 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL1B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:              -     -     -                 -           -                                       
    SP2:                    -     -                 -           -                                       
    SP3:                          -                 -           -                                       
    SP4:              -     -     -                 -                                                   
    SP5:                                            -           -                                       


    ECgene alternative splicing isoforms for IL1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL1B expression in normal human tissues (normalized intensities)      IL1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTTGTGT
    IL1B Expression
    About this image


    IL1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Blood (Cardiovascular System)    fully expand to see all 7 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             Fetal Liver CD34+ Cells   
             monocytes   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 5 entries
             Wharton's jelly-derived stem cells
             Human umbilical Smooth Muscle (HUSM)   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem progenitor RP1-MV2-16

    See IL1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL1B

    SOURCE GeneReport for Unigene cluster: Hs.126256
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL1B (see all 37): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              GABA & Glutamate in human mouse rat
              Inflammasomes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IL1B
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1B
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL1B gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1b1 , 5 interleukin 1 beta1, 5 78.57(n)1
    69.55(a)1
      2 (62.97 cM)5
    161761  NM_008361.31  NP_032387.11 
     1293645705 
    chicken
    (Gallus gallus)
    Aves IL1B1 interleukin 1, beta 50.6(n)
    37.44(a)
      395196  NM_204524.1  NP_989855.1 
    zebrafish
    (Danio rerio)
    Actinopterygii il1b6
    interleukin 1, beta
    21(a)
    1 ↔ 1
    10(46393914-46401024)


    ENSEMBL Gene Tree for IL1B (if available)
    TreeFam Gene Tree for IL1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL1B gene
    1 SIMAP similar gene for IL1B using alignment to 5 protein entries:     IL1B_HUMAN (see all proteins):
    IL1b

    IL1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/257 SNPs in IL1B are shown (see all 257)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30872611,2
    F--106041748(-) GCACAC/TTTGGA 1 -- ds50011Minor allele frequency- T:0.17NA 40
    rs58334641,2
    C--106050892(+) CTTTC-/TTTT  
            
    tcttt
    1 -- us2k10--------
    rs558158771,2
    C--106050965(+) TTTCT-/TC/TCTT/TCT
    TTCTTTCTTTCTT
    CTTTC
    1 -- us2k12NA 4
    rs1844583871,2
    --113100427(+) CTCCTA/GTCTGA 1 -- ds50010--------
    rs1163198351,2
    F--113100485(+) CATAGC/TGCTTG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs28535501,2
    C,F,O,H--113100584(-) CACATC/TTGGAA 1 -- ds500129Minor allele frequency- T:0.18NS EA NA WA CSA 2712
    rs1476364071,2
    --113100617(+) CAACAA/GAAATA 1 -- ds50010--------
    rs39173621,2
    C,F,H--113100681(-) AGTGCT/CGCAAA 1 -- ds500122Minor allele frequency- C:0.02NS EA NA MN WA 2362
    rs27089741,2
    C--113100784(+) CAGGAA/GAGACC 1 -- ds50015Minor allele frequency- G:0.00MN 404
    rs2002953131,2
    --113100790(+) GACCC-/TTTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for IL1B (113587328 - 113594480 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL1B: --

    Human Gene Mutation Database (HGMD): IL1B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1B
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147720   
    OMIM disorders: 137215  
    20/470 diseases for IL1B (see all 470):    About MalaCards
    benign migratory glossitis    central nervous system leukemia    poems syndrome    toxic shock syndrome
    euthyroid sick syndrome    staphylococcal toxic shock syndrome    bagassosis    gastric cancer risk after h. pylori infection
    h. pylori infection    intervertebral disc disease    glossitis    streptococcal toxic-shock syndrome
    opisthorchiasis    gastroesophageal junction adenocarcinoma    spinal cord injury    periodontal disease
    bacterial vaginosis    blau syndrome    wells syndrome    vulvar vestibulitis syndrome

    20/36 diseases from the University of Copenhagen DISEASES database for IL1B (see all 36):
    Arthritis     Periodontitis     Vascular disease     Inflammatory bowel disease
    Cancer     Brain disease     Diabetes mellitus     Asthma
    Hypersensitivity reaction type II disease     Respiratory failure     Pneumonia     Kidney disease
    Skin disease     Alzheimer's disease     Peritonitis     Gastritis
    Synovitis     Heart disease     Pancreatitis     Meningitis

    IL1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for IL1B gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 94.6 6807 8908543 (6), 2239094 (5), 9223915 (5), 10958731 (5) (see all 99)
    inflammation 87.4 725 11776404 (4), 8777275 (4), 8990190 (4), 10444264 (3) (see all 99)
    tumors 85.7 5675 8908543 (6), 1966551 (6), 1752785 (5), 9223915 (5) (see all 99)
    rheumatoid arthritis 79 217 7608561 (3), 2057724 (2), 8135776 (2), 15304675 (2) (see all 99)
    osteoarthritis 72 126 19835118 (3), 2057724 (2), 1616355 (2), 7586981 (2) (see all 95)
    response acute phase 67.1 37 8354339 (2), 11250916 (1), 12177794 (1), 18262272 (1) (see all 30)
    arthritis 67 126 1616355 (2), 11120857 (2), 17397533 (2), 8275587 (2) (see all 88)
    periodontal diseases 66.4 98 16570465 (3), 9203094 (2), 17378884 (2), 15002890 (2) (see all 63)
    sepsis 63.9 142 9773833 (4), 17877801 (3), 18274637 (2), 8945019 (2) (see all 99)
    systemic inflammatory response syndrome 59.9 34 8379598 (2), 7680670 (2), 10101684 (1), 16736416 (1) (see all 21)

    Genetic Association Database (GAD): IL1B
    Human Genome Epidemiology (HuGE) Navigator: IL1B (1184 documents)

    Export disorders for IL1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL1B gene, integrated from 9 sources (see all 7083):
    (articles sorted by number of sources associating them with IL1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human interleukin-1 beta gene. (PubMed id 2954882)1, 2, 3 Bensi G.... Melli M. (1987)
    2. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. (PubMed id 2989698)1, 2, 3 March C.J.... Cosman D. (1985)
    3. Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women. (PubMed id 19904560)1, 4, 9 Qian N....Hu Z. (2009)
    4. Relationship between IL-1beta gene polymorphism and gastric mucosal IL-1beta levels in patients with Helicobacter pylori infection. (PubMed id 16143884)1, 4, 9 Xuan J....Takagi A. (2005)
    5. Interleukin 1-beta responses to bacterial toxins and sudden infant death syndrome. (PubMed id 15325407)1, 4, 9 Moscovis S.M....Blackwell C.C. (2004)
    6. [The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis.] (PubMed id 19220961)1, 4, 9 Chen X.Q....Chen Y.C. (2009)
    7. A functional interleukin-1 receptor antagonist polymo rphism influences atherosclerosis development. The interleukin-1beta:interleuki n-1 receptor antagonist balance in atherosclerosis. (PubMed id 19574724)1, 4, 9 Olofsson P.S....SirsjAP A. (2009)
    8. Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis. (PubMed id 12775358)1, 4, 9 Schrijver H.M....Uitdehaag B.M. (2003)
    9. Interleukin (IL) 1beta and IL-10 gene polymorphism in chronic hepatitis C patients with normal or elevated alanine aminotransferase levels. (PubMed id 12705485)1, 4, 9 Abbas Z. and Moatter T. (2003)
    10. The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer. (PubMed id 11531943)1, 4, 9 Garcia-Gonzalez M.A....Pena A.S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3553 HGNC: 5992 AceView: IL1B Ensembl:ENSG00000125538 euGenes: HUgn3553
    ECgene: IL1B Kegg: 3553 H-InvDB: IL1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL1B Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1b/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL1B gene:
    Search GeneIP for patents involving IL1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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