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Aliases for IL1B Gene

Aliases for IL1B Gene

  • Interleukin 1, Beta 2 3
  • IL-1 Beta 3 4
  • Catabolin 3 4
  • IL1F2 3 4
  • Pro-Interleukin-1-Beta 3
  • Preinterleukin 1 Beta 3
  • IL1-BETA 3
  • IL-1 3

External Ids for IL1B Gene

Previous GeneCards Identifiers for IL1B Gene

  • GC02M110793
  • GC02M111508
  • GC02M113494
  • GC02M113682
  • GC02M113303
  • GC02M106041
  • GC02M113587

Summaries for IL1B Gene

Entrez Gene Summary for IL1B Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1B Gene

IL1B (Interleukin 1, Beta) is a Protein Coding gene. Diseases associated with IL1B include gastric cancer risk after h. pylori infection and periodontal disease. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include protein domain specific binding and interleukin-1 receptor binding.

UniProtKB/Swiss-Prot for IL1B Gene

  • Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

Tocris Summary for IL1B Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1B Gene

Genomics for IL1B Gene

Regulatory Elements for IL1B Gene

Genomic Location for IL1B Gene

Chromosome:
2
Start:
112,829,751 bp from pter
End:
112,836,903 bp from pter
Size:
7,153 bases
Orientation:
Minus strand

Genomic View for IL1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1B Gene

Proteins for IL1B Gene

  • Protein details for IL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01584-IL1B_HUMAN
    Recommended name:
    Interleukin-1 beta
    Protein Accession:
    P01584
    Secondary Accessions:
    • Q53X59
    • Q53XX2
    • Q7M4S7
    • Q7RU01
    • Q96HE5
    • Q9UCT6

    Protein attributes for IL1B Gene

    Size:
    269 amino acids
    Molecular mass:
    30748 Da
    Quaternary structure:
    • Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all (PubMed:17431422).
    Miscellaneous:
    • The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.

    Three dimensional structures from OCA and Proteopedia for IL1B Gene

neXtProt entry for IL1B Gene

Proteomics data for IL1B Gene at MOPED

Post-translational modifications for IL1B Gene

  • Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL1B Gene

Antibody Products

  • R&D Systems Antibodies for IL1B (IL-1 beta/IL-1F2)

Protein Products

No data available for DME Specific Peptides for IL1B Gene

Domains & Families for IL1B Gene

Gene Families for IL1B Gene

Suggested Antigen Peptide Sequences for IL1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01584

UniProtKB/Swiss-Prot:

IL1B_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL1B: view

Function for IL1B Gene

Molecular function for IL1B Gene

GENATLAS Biochemistry:
interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively stimulating osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory response,susceptibility factor for inflammatory bowel diseaes
UniProtKB/Swiss-Prot Function:
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
UniProtKB/Swiss-Prot Induction:
By LPS.

LifeMap Function Summary for IL1B Gene

IL1B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IMP 2989698
GO:0005149 interleukin-1 receptor binding NAS 1919436
GO:0019904 protein domain specific binding IPI 16575408
genes like me logo Genes that share ontologies with IL1B: view
genes like me logo Genes that share phenotypes with IL1B: view

Animal Models for IL1B Gene

MGI Knock Outs for IL1B:

Animal Model Products

miRNA for IL1B Gene

miRTarBase miRNAs that target IL1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL1B Gene

Localization for IL1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1B Gene

Cytoplasm, cytosol. Lysosome. Secreted, exosome. Cytoplasmic vesicle, autophagosome. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathway(s) of its secretion is(are) not yet fully understood (PubMed:24201029). On the basis of experimental results, several unconventional secretion mechanisms have been proposed. 1. Secretion via secretory lysosomes: a fraction of CASP1 and IL1B precursor may be incorporated, by a yet undefined mechanism, into secretory lysosomes that undergo Ca(2+)-dependent exocytosis with release of mature IL1B (PubMed:15192144). 2. Secretory autophagy: IL1B-containing autophagosomes may fuse with endosomes or multivesicular bodies (MVBs) and then merge with the plasma membrane releasing soluble IL1B or IL1B-containing exosomes (PubMed:24201029). However, autophagy impacts IL1B production at several levels and its role in secretion is still controversial. 3. Secretion via exosomes: ATP-activation of P2RX7 leads to the formation of MVBs containing exosomes with entrapped IL1B, CASP1 and other inflammasome components. These MVBs undergo exocytosis with the release of exosomes. The release of soluble IL1B occurs after the lysis of exosome membranes (By similarity). 4. Secretion by microvesicle shedding: activation of the ATP receptor P2RX7 may induce an immediate shedding of membrane-derived microvesicles containing IL1B and possibly inflammasome components. The cytokine is then released in the extracellular compartment after microvesicle lysis (PubMed:11728343). 5. Release by translocation through permeabilized plasma membrane. This may occur in cells undergoing pyroptosis due to sustained activation of the inflammasome (By similarity). These mechanisms may not be not mutually exclusive. {ECO:0000250 UniProtKB:P10749, ECO:0000269 PubMed:11728343, ECO:0000269 PubMed:15192144, ECO:0000305 PubMed:24201029}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1B Gene COMPARTMENTS Subcellular localization image for IL1B gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
peroxisome 2
vacuole 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IMP 3493774
GO:0005764 lysosome IEA --
GO:0005776 autophagosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IL1B: view

Pathways & Interactions for IL1B Gene

genes like me logo Genes that share pathways with IL1B: view

PCR Array Products

SIGNOR curated interactions for IL1B Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000165 MAPK cascade IMP 21147091
GO:0000187 activation of MAPK activity IDA 10748004
GO:0001660 fever generation IBA --
GO:0001666 response to hypoxia IEA --
genes like me logo Genes that share ontologies with IL1B: view

Drugs & Compounds for IL1B Gene

(92) Drugs for IL1B Gene - From: NovoSeek, PharmGKB, DGIdb, ApexBio, Tocris, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
canakinumab Approved, Investigational Pharma immunotherapy, antibody, Target, binder Immunotherapies 0
Rilonacept Approved Pharma binder, Target 0
Gallium nitrate Approved, Investigational Pharma Target, antagonist 6
Minocycline Approved, Investigational Pharma Target, modulator 162
Clodronate Approved, Investigational Pharma 0

(76) Additional Compounds for IL1B Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-IPP
41270-96-6
AS 101
106566-58-9
GIT 27
6501-72-0
15-deoxy-delta-12,14-prostaglandin j2
87893-55-8
2,3-dideoxyadenosine
genes like me logo Genes that share compounds with IL1B: view

Transcripts for IL1B Gene

Unigene Clusters for IL1B Gene

Interleukin 1, beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -

Relevant External Links for IL1B Gene

GeneLoc Exon Structure for
IL1B
ECgene alternative splicing isoforms for
IL1B

Expression for IL1B Gene

mRNA expression in normal human tissues for IL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1B Gene

This gene is overexpressed in Whole Blood (x17.8) and Stomach (x4.1).

Protein differential expression in normal tissues from HIPED for IL1B Gene

This gene is overexpressed in Pancreas (44.9) and Bone (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1B Gene



SOURCE GeneReport for Unigene cluster for IL1B Gene Hs.126256

mRNA Expression by UniProt/SwissProt for IL1B Gene

P01584-IL1B_HUMAN
Tissue specificity: Expressed in activated monocytes/macrophages (at protein level).
genes like me logo Genes that share expression patterns with IL1B: view

Protein tissue co-expression partners for IL1B Gene

Primer Products

In Situ Assay Products

Orthologs for IL1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL1B 35
  • 75.38 (n)
  • 62.12 (a)
IL1B 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1B 35
  • 78.28 (n)
  • 65.15 (a)
IL1B 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1b 35
  • 78.45 (n)
  • 69.55 (a)
Il1b 16
Il1b 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1B 35
  • 99.5 (n)
  • 99.26 (a)
IL1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1b 35
  • 76.32 (n)
  • 68.42 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1B 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1B 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL-1BETA 36
  • 25 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il1b 35
  • 48.77 (n)
  • 39.3 (a)
zebrafish
(Danio rerio)
Actinopterygii il1b 36
  • 21 (a)
OneToOne
Species with no ortholog for IL1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1B Gene

ENSEMBL:
Gene Tree for IL1B (if available)
TreeFam:
Gene Tree for IL1B (if available)

Paralogs for IL1B Gene

(1) SIMAP similar genes for IL1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IL1B: view

No data available for Paralogs for IL1B Gene

Variants for IL1B Gene

Sequence variations from dbSNP and Humsavar for IL1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3136557 -- 112,833,765(-) tcatc(A/C/T)acctc intron-variant
rs3136558 -- 112,833,698(-) GATGA(C/T)CTTTA intron-variant
rs3917346 -- 112,837,229(-) GGCTA(G/T)TGGCC upstream-variant-2KB
rs3917347 -- 112,836,628(-) ATATT(-/CT)CTCTC intron-variant, upstream-variant-2KB
rs3917348 -- 112,836,171(-) GGAGA(C/T)GCTGA intron-variant

Variation tolerance for IL1B Gene

Residual Variation Intolerance Score: 28.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1B Gene

HapMap Linkage Disequilibrium report
IL1B
Human Gene Mutation Database (HGMD)
IL1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL1B Gene

Disorders for IL1B Gene

MalaCards: The human disease database

(188) MalaCards diseases for IL1B Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer risk after h. pylori infection
  • gastric cancer, somatic
periodontal disease
  • periodontium disorder
cervical adenitis
  • cervical lymphadenitis
physiological polycythemia
gingivitis
  • chronic gingivitis
- elite association
Search IL1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL1B

Genetic Association Database (GAD)
IL1B
Human Genome Epidemiology (HuGE) Navigator
IL1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1B
genes like me logo Genes that share disorders with IL1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1B Gene

Publications for IL1B Gene

  1. Human monocyte activation by biologic and biodegradable meshes in vitro. (PMID: 19697086) Orenstein S.B. … Novitsky Y.W. (Surg Endosc 2010) 23 67
  2. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. (PMID: 19878610) Epstein J. … Sanderson I.R. (Br. J. Nutr. 2010) 23 67
  3. Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. (PMID: 20018936) Wang B. … Khachigian L.M. (Arterioscler. Thromb. Vasc. Biol. 2010) 23 67
  4. Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways. (PMID: 20026325) Chen M. … Aass I. (Exp. Eye Res. 2010) 23 67
  5. Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kappaB. (PMID: 20069553) Lee C.W. … Yang C.M. (J. Cell. Biochem. 2010) 23 67

Products for IL1B Gene

  • Addgene plasmids for IL1B

Sources for IL1B Gene

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