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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL1B Gene

protein-coding GIFtS: 71
GCID: GC02M113587

interleukin 1, beta

Explore 517 diseases affiliated with
IL1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 1, Beta¹ ²		Catabolin³
IL1F2¹ ² ³		Interleukin-1 Beta²
IL1-BETA¹ ²		Preinterleukin 1 Beta²
IL-1 Beta² ³		Pro-Interleukin-1-Beta¹
IL-1B¹		Catabolin³
IL-1²

External Ids:	HGNC: 5992¹	Entrez Gene: 3553²	Ensembl: ENSG00000125538⁷	OMIM: 147720⁵	UniProtKB: P01584³

Export aliases for IL1B gene to outside databases

Previous GC identifers: GC02M110793 GC02M111508 GC02M113494 GC02M113682 GC02M113303 GC02M106041

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL1B:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by

activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE).

This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular

activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2

(PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain

hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell

maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory

response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and

collagenase from synovial cells

summary for IL1B:

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They

control many different cellular functions including proliferation, differentiation and cell

survival/apoptosis but are also involved in several pathophysiological processes including viral infections

and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the

innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can

be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,

IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.

Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL1B gene promoter:
COUP-TF1 AP-1 ATF-2 COUP HNF-4alpha2 HNF-4alpha1 COUP-TF STAT3 GR-alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL1B promoter sequence

Search SABiosciences Chromatin IP Primers for IL1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q14

IL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1B gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M113587: view genomic region (about GC identifiers)

Start:	113,587,328 bp from pter	End:	113,594,480 bp from pter
Size:	7,153 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584 (See protein sequence)

Recommended Name: Interleukin-1 beta precursor

Size: 269 amino acids; 30748 Da

Subunit: Monomer

Subcellular location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that

IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins

6/28 PDB 3D structures from and Proteopedia for IL1B (see all 28):

1HIB (3D)

1I1B (3D)

1IOB (3D)

1ITB (3D)

1L2H (3D)

1S0L (3D)

Secondary accessions: Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6

Explore the universe of human proteins at neXtProt for IL1B: NX_P01584

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01584

IL1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000567.1

ENSEMBL proteins:

ENSP00000263341 ENSP00000407219 ENSP00000409680 ENSP00000400854

Reactome Protein details: P01584
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IL1B Protein
	R&D Systems Recombinant & Natural Proteins for IL1B (IL-1 beta/IL-1F2)
	Enzo Life Sciences proteins for IL1B
	OriGene Purified Proteins (see all 2): IL1B OriGene Protein Over-expression Lysate: IL1B OriGene Custom Protein Services for IL1B
	GenScript Purified and Recombinant Proteins for IL1B
	Novus Biologicals IL1B Proteins Novus Biologicals IL1B Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL1B
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IMP	3493774
GO:0005829	cytosol	TAS	--
GO:0030141	secretory granule	IEA	--
GO:0031982	vesicle	--	--

IL1B for ontologies About GeneDecksing

IL1B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL1B
	R&D Systems Antibodies for IL1B (IL-1 beta/IL-1F2)
	OriGene Antibodies (see all 3): IL1B OriGene Custom Antibody Services for IL1B
	GenScript Superior Antibodies for IL1B
	Novus Biologicals IL1B Antibodies
	Abcam antibodies for IL1B
	Browse Antibodies at Uscn
	ThermoFisher Antibody for IL1B

Assay Products for IL1B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL1B (IL-1 beta/IL-1F2) (see all)
	GenScript Custom Assay Services for IL1B
	Enzo Life Sciences assays for IL1B
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL1B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003502 IL1_propep

IPR020877 Interleukin-1_CS

IPR002348 IL1_HBGF

IPR008996 Cytokine_IL1-like

IPR003296 InterleukinIL1B

Graphical View of Domain Structure for InterPro Entry P01584

ProtoNet protein and cluster: P01584

5 Blocks protein families:

IPB000975 Interleukin-1 precursor family signature

IPB002348 IL1/HBGF family signature

IPB003294 Interleukin-1 alpha/beta precursor family signature

IPB003296 Interleukin-1 beta precursor signature

IPB003502 Interleukin-1 propeptide

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584

Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet

undefined function

Similarity: Belongs to the IL-1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL1B_HUMAN, P01584

Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell

maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory

response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and

collagenase from synovial cells

Genatlas biochemistry entry for IL1B:

interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively stimulating

osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory response,susceptibility

factor for inflammatory bowel diseaes

Summary:

IL1B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Mature dendritic-like cells, Macrophage-like cells

miRNA Products:		miRTarBase miRNAs that target IL1B: hsa-mir-204 (MIRT005830), hsa-mir-21 (MIRT005951)

		OriGene 3'-UTR Clone: IL1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1B
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1B:
		hsa-miR-205* hsa-miR-3121-3p hsa-miR-1291
		SwitchGear 3'UTR luciferase reporter plasmid: IL1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL1B (see all 7) OriGene shRNA RFP: IL1B OriGene siRNA: IL1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL1B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL1B (NM_000576)
		Sino Biological Human cDNA Clone for IL1B
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL1B
		Search LifeMap BioReagents cell lines for IL1B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1B

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IMP	2989698
GO:0005149	interleukin-1 receptor binding	NAS	1919436
GO:0008083	growth factor activity	IEA	--
GO:0019904	protein domain specific binding	IPI	16575408

IL1B for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for IL1B: Il1b^tm1Lvp Il1b^tm1Dch
     7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il1b):

cardiovascular system	homeostasis/metabolism	immune system	mortality/aging	nervous system
skeleton	tumorigenesis

IL1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/62 super-pathways (see all 62) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.29
JAK-STAT Pathway	0.57

Toll-like receptor signaling pathway

Toll-like receptor signaling pathway	1.00	Chagas disease (American trypanosomiasis)	0.31
Toll-like receptor signaling pathway	0.97	Inflammasome Activation Pathways	0.29
Toll-Like receptor Signaling Pathways	0.51

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61			MAPK Signaling	0.51

Immune response_Bacterial infections in normal airways

	Immune response_Bacterial infections in normal airways	1.00			IL-1 beta-dependent CFTR expression	0.43
	Bacterial infections in CF airways	0.78

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for IL1B

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Selected targets of GCR-alpha
	Immune response MIF in innate immunity response
	Immune response IL-1 signaling pathway

5 R&D Systems Pathways for IL1B

	Inflammasome Activation Pathways
	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Toll-Like receptor Signaling Pathways
	Th17 Differentiation

5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL1B (see all 38)

	14-3-3 Induced Apoptosis
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Tec Kinases Signaling
	Rho Family GTPases

2 Cell Signaling Technology (CST) Pathways for IL1B

	Jak/Stat Pathway
	NF-kappaB Signaling

3 Tocris Bioscience Pathways for IL1B

	Akt Pathway
	Toll-like Receptor Pathway
	MAPK Pathway

5/6 GeneGo (Thomson Reuters) Pathways for IL1B (see all 6)

	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Bacterial infections in CF airways
	IL-1 beta-dependent CFTR expression

5/19 BioSystems Pathways for IL1B (see all 19)

	Senescence and Autophagy
	NOD pathway
	SIDS Susceptibility Pathways
	MAPK signaling pathway
	Cytokines and Inflammatory Response

5/7 Reactome Pathways for IL1B (see all 7)

	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
	Interleukin-1 signaling
	Interleukin-1 processing
	Cytokine Signaling in Immune system
	Interleukin-1 family are secreted

5/22 Kegg Pathways (Kegg details for IL1B) (see all 22):

	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	Apoptosis
	Osteoclast differentiation
	Toll-like receptor signaling pathway

IL1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for IL1B (P01584^{2, 3} ENSP00000263341⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL1R1	P14778²^,³, ENSP00000233946⁴	MINT-24831 I2D: score=8 STRING: ENSP00000233946
IL1RAP	Q9NPH3³, ENSP00000072516⁴	I2D: score=3 STRING: ENSP00000072516
ADRB2	P07550³, ENSP00000305372⁴	I2D: score=2 STRING: ENSP00000305372
CASP4	P49662³, ENSP00000388566⁴	I2D: score=2 STRING: ENSP00000388566
MAPK8IP2	Q13387³, ENSP00000330572⁴	I2D: score=1 STRING: ENSP00000330572

About this table

Gene Ontology (GO): 5/98 biological process terms (GO ID links to tree view) (see all 98): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	IMP	--
GO:0000187	activation of MAPK activity	IDA	10748004
GO:0001660	fever generation	IEA	--
GO:0001666	response to hypoxia	--	--
GO:0001934	positive regulation of protein phosphorylation	NAS	16477012

IL1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for IL1B available from Tocris Bioscience About this table

Compound	Action	CAS #
AF 12198	Potent, selective human type I IL-1 receptor antagonist	[185413-30-3]

3 DrugBank Compounds for IL1B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Minocycline	--	10118-90-8	target	modulator	11246672 8943052 9413935 12211491
Canakinumab	ACZ-885 (see all 2)	914613-48-2	target	--	19169963
Gallium nitrate	--	13494-90-1	target	antagonist	16122880

10/136 Novoseek chemical compound relationships for IL1B gene (see all 136) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pge2	85.5	1669	15135319 (8), 19452719 (8), 17438251 (7), 1668251 (6) (see all 99)
rantes	80.6	362	11600537 (6), 19080516 (6), 15499983 (6), 11063385 (5) (see all 99)
endotoxin	78.9	487	15499983 (6), 9659298 (5), 10908988 (5), 15325407 (5) (see all 99)
il 10	71.4	89	17022949 (3), 18832862 (3), 10645445 (2), 16842617 (2) (see all 63)
dexamethasone	71.1	456	17513787 (6), 9758209 (5), 10657942 (5), 19435930 (4) (see all 99)
nitric oxide	70.8	1245	10025918 (6), 1384465 (6), 11247871 (6), 9160463 (5) (see all 99)
cycloheximide	69.4	155	1384465 (3), 1732280 (2), 9144567 (2), 1918980 (2) (see all 99)
prostaglandin	69.1	243	1641502 (4), 8140125 (3), 9419743 (3), 9047011 (3) (see all 99)
indomethacin	63.5	183	12639911 (4), 9627083 (4), 10772282 (4), 1348040 (4) (see all 99)
sb 203580	63.3	64	12921636 (4), 18348730 (4), 17207362 (2), 20416175 (2) (see all 47)

5 PharmGKB related drug/compound annotations for IL1B gene

Drug/compound	PharmGKB Annotation
Bisphosphonates	CA
clodronate	CA
etidronic acid	CA
risedronate	CA
tiludronate	CA

About this table

Search CenterWatch for drugs/clinical trials and news about IL1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL1B gene:

NM_000576.2

Unigene Cluster for IL1B:

Interleukin 1, beta

Hs.126256 [show with all ESTs]

Unigene Representative Sequence: AK313983

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263341(uc002tih.1 uc002tii.1) ENST00000491056 ENST00000487639

ENST00000418817 ENST00000432018 ENST00000416750 ENST00000496280 ENST00000477398

miRNA Products:		OriGene 3'-UTR Clone: IL1B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL1B
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IL1B:
		hsa-miR-205* hsa-miR-3121-3p hsa-miR-1291
		SwitchGear 3'UTR luciferase reporter plasmid: IL1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL1B (see all 7) OriGene shRNA RFP: IL1B OriGene siRNA: IL1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL1B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL1B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL1B (NM_000576)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL1B

Additional cDNA sequence:

AB451494.1 AF043335.1 AK313983.1 BC008678.1 BT007213.1 CR407679.1 K02770.1 M15330.1

M54933.1 X02532.1 X56087.1

8 DOTS entries:

DT.454455 DT.95307325 DT.101987199 DT.100026384 DT.121014363 DT.121014359 DT.95375716 DT.102824241

24/440 AceView cDNA sequences (see all 440):

BP335163 X02532 BP335911 CD240414 BQ001221 CA305984 BP337042 AA381516

CA431534 AA362191 BP336766 BP337036 BP337439 BP335557 AA133295 CB146078

BQ000281 CD367786 CA309582 BP335879 BP336100 BP336610 BP335514 BU626613

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL1B (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8
SP1:					-		-		-						-				-
SP2:							-		-						-				-
SP3:									-						-				-
SP4:					-		-		-						-
SP5:															-				-

ECgene alternative splicing isoforms for IL1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATTTGTGT

About this image

IL1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Early Embryo (Zygote)

Morula

8-Cell Embryo

Early Embryo

Early Embryo (Zygote)

Morula

Morula Cells

Early Embryo

Early Embryo (Zygote)

Zygote

Early Embryo

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Placenta

Extravillous Cytotrophoblast Layer

Extravillous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Adipose

Visceral White Adipose

Adipose

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

White adipocyte-like cells (Differentiation of ...)

Adipose

See IL1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL1B

SOURCE GeneReport for Unigene cluster: Hs.126256

SABiosciences Expression via Pathway-Focused PCR Arrays including IL1B (see all 37):

Antiviral Response in human mouse rat

Multiple Sclerosis in human mouse rat

Wound Healing in human mouse rat

GABA & Glutamate in human mouse rat

Inflammasomes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL1B Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL1B gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il1b^{1 , 5}	interleukin 1 beta^{1, 5}	78.57(n)¹ 69.55(a)¹		2 (62.97 cM)⁵ 16176¹ NM_008361.3¹ NP_032387.1¹ 129364570⁵
chicken (Gallus gallus)	Aves	IL1B¹	interleukin 1, beta	50.6(n) 37.44(a)		395196 NM_204524.1 NP_989855.1
zebrafish (Danio rerio)	Actinopterygii	il1b⁶	interleukin 1, beta	21(a)	1 ↔ 1	10(46393914-46401024)

ENSEMBL Gene Tree for IL1B (if available)
TreeFam Gene Tree for IL1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3087261^1,2	F	--	106041749(-)	`GCACAC/TTTGGA`	1	--	ds500¹		1	NA	40
rs3917362^1,2	C,F,H,	--	106041845(-)	`AGTGCT/CGCAAA`	1	--	ds500¹		22	NS EA NA MN WA	2362
rs2708974^1,2	C	--	106041948(+)	`CAGGAA/GAGACC`	1	--	ds500¹		5	MN	404
rs1071676^1,2	C,F,O,A,H,	--	106042060(-)	`ATTAAG/CACTGA`	1	--	ut3¹		17	NA NS MN CSA WA EA	1160
rs15610^1,2	C	--	106042149(-)	`TAGCAG/TTGTCT`	1	--	ut3¹ ese³		6	MN	584
rs10176689^1,2	C,	--	106042464(+)	`GGAAAG/TTCCAG`	1	--	ut3¹ ese³		4	NA WA	260
rs1143644^1,2	C,F,	--	106042828(-)	`CCCATA/GGCATC`	1	--	int¹		4	NA MN WA	350
rs3917361^1,2	C,F	--	106043017(-)	`CCCCCA/CAAAAA`	1	--	int¹ trp³		3	NS CSA	96
rs3917380^1,2	C	--	106043019(-)	`CCCCCC/GCAAAA`	1	--	int¹		3	NS NA	96
rs3917379^1,2	C,	--	106043140(-)	`CCTCCA/GGCTTT`	1	--	int¹		3	NS NA	96

HapMap Linkage Disequilibrium report for IL1B (113587328 - 113594480 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL1B: --
Human Gene Mutation Database (HGMD): IL1B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL1B

DNA2.0 Custom Variant and Variant Library Synthesis for IL1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL1B for disorders           About GeneDecksing

OMIM gene information: 147720
OMIM disorders: 137215
20/517 diseases for IL1B (see all 517):    About MalaCards

ossification of posterior longitudinal ligament of spine gastric cancer risk after h. pylori infection muckle-wells syndrome open-angle glaucoma

chronic infantile neurological cutaneous articular syndrome monoclonal gammopathy of undetermined significance erdheim-chester disease benign migratory glossitis

spinal cord injury euthyroid sick syndrome adult-onset still's disease endotoxin hyporesponsiveness

relapsing-remitting multiple sclerosis familial cold autoinflammatory syndrome h. pylori infection extrinsic allergic alveolitis

pre-eclampsia intervertebral disc disease middle ear cholesteatoma stachybotrys chartarum

20/35 diseases from the University of Copenhagen DISEASES database for IL1B (see all 35):

Arthritis Periodontitis Vascular disease Inflammatory bowel disease

Cancer Brain disease Diabetes mellitus Asthma

Hypersensitivity reaction type II disease Alzheimer's disease Pneumonia Respiratory failure

Kidney disease Skin disease Gastritis Peritonitis

Synovitis Heart disease Pancreatitis Meningitis

10/94 Novoseek disease relationships for IL1B gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	94.6	6807	8908543 (6), 2239094 (5), 9223915 (5), 10958731 (5) (see all 99)
inflammation	87.4	725	11776404 (4), 8777275 (4), 8990190 (4), 10444264 (3) (see all 99)
tumors	85.7	5675	8908543 (6), 1966551 (6), 1752785 (5), 9223915 (5) (see all 99)
rheumatoid arthritis	79	217	7608561 (3), 2057724 (2), 8135776 (2), 15304675 (2) (see all 99)
osteoarthritis	72	126	19835118 (3), 2057724 (2), 1616355 (2), 7586981 (2) (see all 95)
response acute phase	67.1	37	8354339 (2), 11250916 (1), 12177794 (1), 18262272 (1) (see all 30)
arthritis	67	126	1616355 (2), 11120857 (2), 17397533 (2), 8275587 (2) (see all 88)
periodontal diseases	66.4	98	16570465 (3), 9203094 (2), 17378884 (2), 15002890 (2) (see all 63)
sepsis	63.9	142	9773833 (4), 17877801 (3), 18274637 (2), 8945019 (2) (see all 99)
systemic inflammatory response syndrome	59.9	34	8379598 (2), 7680670 (2), 10101684 (1), 16736416 (1) (see all 21)

Genetic Association Database (GAD): IL1B
Human Genome Epidemiology (HuGE) Navigator: IL1B (1184 documents)

Export disorders for IL1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL1B gene, integrated from 9 sources (see all 6974):
(articles sorted by number of sources associating them with IL1B)

Utopia: connect your pdf to the dynamic
world of online information

Human interleukin-1 beta gene. (PubMed id 2954882)^{1, 2, 3} Bensi G.... Melli M. (1987)
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. (PubMed id 2989698)^{1, 2, 3} March C.J.... Cosman D. (1985)
Lack of association with interleukin 1 receptor antagonist and interleukin-1beta gene polymorphisms in sarcoidosis patients. (PubMed id 11127488)^{1, 4, 9} Niimi T....Ueda R. (2000)
Interleukin 1 and nuclear factor-kappaB polymorphisms in ankylosing spondylitis in Canada and Korea. (PubMed id 16206345)^{1, 4, 9} Kim T.H....Inman R.D. (2005)
Lack of association of genetic polymorphisms in the interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese. (PubMed id 12578333)^{1, 4, 9} Chou H.T....Tsai F.J. (2003)
Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and Crohn disease in multiple populations from northeast England. (PubMed id 11686217)^{1, 4, 9} Craggs A....Mansfield J. (2001)
The role of arginine residues in interleukin 1 receptor binding. (PubMed id 1837236)^{1, 2, 9} Nanduri V.B.... Stern A.S. (1991)
Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. (PubMed id 15900570)^{1, 4, 9} Wu S.F....Tsai F.J. (2005)
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. (PubMed id 16098232)^{1, 4, 9} Ohashi J....Tokunaga K. (2005)
Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease. (PubMed id 15201366)^{1, 4, 9} Bosco P....Gueant J.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3553	HGNC: 5992	AceView: IL1B	Ensembl:ENSG00000125538	euGenes: HUgn3553
ECgene: IL1B	Kegg: 3553	H-InvDB: IL1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL1B	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_1
SeattleSNPs	http://pga.gs.washington.edu/data/il1b/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B

Intellectual Property for IL1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL1B gene:
Search GeneIP for patents involving IL1B

GeneCards and IP:
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IL1B Gene

interleukin 1, beta

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CINCA SYNDROME
POEMS Syndrome
Gingivitis
preterm delivery
INTERVERTEBRAL DISC DISEASE
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IL1B Gene

interleukin 1, beta

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