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IL1A Gene

protein-coding   GIFtS: 66
GCID: GC02M113531

Interleukin 1, Alpha


(Previous symbol: IL1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 1, Alpha1 2     IL-1 Alpha2 3
IL11 2     IL-1A2
hematopoietin-11 2     IL1-ALPHA2
Preinterleukin 1 Alpha1 2     Interleukin-1 Alpha2
pro-interleukin-1-alpha1 2     Hematopoietin-13
IL1F12 3     

External Ids:    HGNC: 59911   Entrez Gene: 35522   Ensembl: ENSG000001150087   OMIM: 1477605   UniProtKB: P015833   

Export aliases for IL1A gene to outside databases

Previous GC identifers: GC02M110737 GC02M111452 GC02M113438 GC02M113626 GC02M113247 GC02M105986


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL1A Gene:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic
cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is
produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in
response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a
cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated
with rheumatoid arthritis and Alzheimer's disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL1A Gene:
IL1A (interleukin 1, alpha) is a protein-coding gene. Diseases associated with IL1A include nephropathia epidemica, and acute hemorrhagic conjunctivitis. GO annotations related to this gene include interleukin-1 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL1A_HUMAN, P01583
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release,
B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the
inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of
prostaglandin and collagenase from synovial cells

summary for IL1A Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL1A gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL1A promoter sequence
   Search Chromatin IP Primers for IL1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14

IL1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL1A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M113531:  view genomic region     (about GC identifiers)

Start:
113,531,492 bp from pter      End:
113,542,971 bp from pter
Size:
11,480 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL1A_HUMAN, P01583 (See protein sequence)
Recommended Name: Interleukin-1 alpha precursor  
Size: 271 amino acids; 30607 Da
Subunit: Monomer
4 PDB 3D structures from and Proteopedia for IL1A:
1ITA (3D)        2ILA (3D)        2KKI (3D)        2L5X (3D)    
Secondary accessions: Q53QF9 Q7RU02

Explore the universe of human proteins at neXtProt for IL1A: NX_P01583

Explore proteomics data for IL1A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn102, Asn141
  • Modification sites at PhosphoSitePlus

  • See IL1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000566.3  
    ENSEMBL proteins: 
     ENSP00000263339  
    Reactome Protein details: P01583

    IL1A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL1A Protein
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    OriGene Purified Protein for IL1A
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    GenScript Purified and Recombinant Proteins for IL1A
    Novus Biologicals IL1A Proteins
    Novus Biologicals IL1A Lysate
    Sino Biological Recombinant Protein for IL1A
    Sino Biological Cell Lysate for IL1A
    ProSpec Recombinant Protein for IL1A
    Browse Proteins at Cloud-Clone Corp.

    IL1A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals IL1A Antibodies
    Abcam antibodies for IL1A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IL1A
    LSBio Antibodies in human, mouse, rat for IL1A

    IL1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL1A
    R&D Systems Flow Cytometry Kits for IL1A (IL-1 alpha/IL-1F1)         (see all)
    GenScript Custom Assay Services for IL1A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    IL: Interleukins and interleukin receptors

    Selected InterPro protein domains (see all 6):
     IPR003502 IL-1_propep
     IPR000975 IL-1
     IPR003295 IL-1_alpha
     IPR020877 IL-1_CS
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry P01583

    ProtoNet protein and cluster: P01583

    5 Blocks protein domains:
    IPB000975 Interleukin-1 precursor family signature
    IPB002348 IL1/HBGF family signature
    IPB003294 Interleukin-1 alpha/beta precursor family signature
    IPB003295 Interleukin-1 alpha precursor signature
    IPB003502 Interleukin-1 propeptide


    UniProtKB/Swiss-Prot: IL1A_HUMAN, P01583
    Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet
    undefined function
    Similarity: Belongs to the IL-1 family


    IL1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL1A_HUMAN, P01583
    Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release,
    B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the
    inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of
    prostaglandin and collagenase from synovial cells

         Genatlas biochemistry entry for IL1A:
    interleukin 1,alpha polypeptide,mainly expressed by macrophage,involved in the inflammatory response

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IMP2989698
    GO:0005149interleukin-1 receptor binding IEA--
    GO:0005507copper ion binding IDA12746488
    GO:0005515protein binding IPI12746488
         
    IL1A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for IL1A:
     Decreased Salmonella enterica   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il1a):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  tumorigenesis 

    IL1A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL1A:
    hsa-mir-191-5p (MIRT004689), hsa-mir-335-5p (MIRT017051)

    Block miRNA regulation of human, mouse, rat IL1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL1A (see all 26):
    hsa-miR-30c hsa-miR-579 hsa-miR-520d-5p hsa-miR-181c hsa-miR-30d hsa-miR-340 hsa-miR-609 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIL1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL1A
    Predesigned siRNA for gene silencing in human, mouse, rat IL1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL1A

    Clone
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    OriGene clones in human, mouse for IL1A (see all 7)
    OriGene ORF clones in mouse, rat for IL1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL1A (NM_000575)
    Sino Biological Human cDNA Clone for IL1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL1A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL1A_HUMAN, P01583: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests
    that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory
    proteins
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    cytoskeleton2
    nucleus2
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IMP3493774
    GO:0005829cytosol IDA12746488

    IL1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL1A About   (see all 43)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL-1 Signaling Pathway0.00
    IL1-mediated signaling events0.45
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44
    Immune response IL 1 signaling pathway0.42
    5Apoptosis (KEGG)
    14-3-3 Induced Apoptosis0.37
    Apoptosis0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL1A
        IL-1 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL1A (see all 35)
        14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Rho Family GTPases

    3 Tocris Bioscience Pathways for IL1A
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    4 GeneGo (Thomson Reuters) Pathways for IL1A
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription NF-kB signaling pathway
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Immune response IL-1 signaling pathway

    Selected BioSystems Pathways for IL1A (see all 11)
        MAPK signaling pathway
    Cytokines and Inflammatory Response
    Senescence and Autophagy
    SIDS Susceptibility Pathways
    FAS pathway and Stress induction of HSP regulation


    3 Reactome Pathways for IL1A
        Interleukin-1 signaling
    Senescence-Associated Secretory Phenotype (SASP)
    Interleukin-1 processing


    Selected Kegg Pathways  (Kegg details for IL1A) (see all 17):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    Apoptosis
    Osteoclast differentiation
    Hematopoietic cell lineage


    IL1A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1A (see all 20): 
              Alzheimer's Disease in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL1A (P015831, 3 ENSP000002633394) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP1P294661, 3, ENSP000004100764EBI-1749782,EBI-516667 I2D: score=2 STRING: ENSP00000410076
    HAX1O001653, ENSP000003290024I2D: score=5 STRING: ENSP00000329002
    IL1R1P147783, ENSP000002339464I2D: score=4 STRING: ENSP00000233946
    NDNQ996083, ENSP000003326434I2D: score=3 STRING: ENSP00000332643
    CAPN1P073843, ENSP000002792474I2D: score=2 STRING: ENSP00000279247
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001660fever generation IEA--
    GO:0006915apoptotic process TAS1924307
    GO:0006954inflammatory response TAS6209582
    GO:0006955immune response IEA--
    GO:0008283cell proliferation TAS6209582

    IL1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for IL1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    Selected Novoseek inferred chemical compound relationships for IL1A gene (see all 142)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pge2 74.5 325 1873492 (5), 8003632 (5), 11167182 (5), 16169897 (4) (see all 99)
    rantes 68.9 94 9527395 (5), 16719905 (4), 18251943 (3), 9644628 (2) (see all 66)
    cycloheximide 62 33 10896254 (1), 1997187 (1), 8225400 (1), 7675826 (1) (see all 21)
    endotoxin 59.5 76 8238178 (6), 1517391 (4), 8882171 (3), 8247820 (2) (see all 46)
    il 10 57.7 28 18832862 (3), 10645445 (1), 10985667 (1), 16389181 (1) (see all 21)
    indomethacin 56.8 47 8847725 (4), 8724299 (3), 10548365 (2), 8004823 (2) (see all 26)
    prostaglandin 53.9 63 7697373 (4), 10209072 (3), 9839700 (2), 15854322 (2) (see all 30)
    tenidap 49.4 3 8244085 (1), 7605611 (1)
    dexamethasone 48.6 58 7621583 (3), 1651357 (3), 8600162 (3), 8429822 (3) (see all 34)
    gm-csf 48.5 14 8724299 (4), 16847181 (1), 2403584 (1), 9629249 (1) (see all 7)



    IL1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL1A gene: 
    NM_000575.3  

    Unigene Cluster for IL1A:

    Interleukin 1, alpha
    Hs.1722  [show with all ESTs]
    Unigene Representative Sequence: NM_000575
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263339(uc002tig.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat IL1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL1A (see all 26):
    hsa-miR-30c hsa-miR-579 hsa-miR-520d-5p hsa-miR-181c hsa-miR-30d hsa-miR-340 hsa-miR-609 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidIL1A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IL1A
    Predesigned siRNA for gene silencing in human, mouse, rat IL1A
    Clone
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    OriGene clones in human, mouse for IL1A (see all 7)
    OriGene ORF clones in mouse, rat for IL1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL1A (NM_000575)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL1A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL1A
    OriGene qSTAR qPCR primer pairs in human, mouse for IL1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL1A
      QuantiTect SYBR Green Assays in human, mouse, rat IL1A
      QuantiFast Probe-based Assays in human, mouse, rat IL1A

    Additional mRNA sequence: 

    AK314850.1 BC013142.2 BC035169.2 BT007014.1 CR457414.1 M15329.1 X02851.1 X56086.1 

    3 DOTS entries:

    DT.413232  DT.121030910  DT.100746168 

    Selected AceView cDNA sequences (see all 56):

    BQ222873 NM_000575 BC013142 BU168358 CB129378 C00156 BT007014 AA831119 
    AA832199 X56086 AI655493 BP336175 BF589176 BF062361 BP336556 M15329 
    BM912073 BP337706 BP337525 BV187719 BU753097 AA922689 BV202891 AI026629 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL1A expression in normal human tissues (normalized intensities)      IL1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACCACTGT
    IL1A Expression
    About this image


    IL1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 2 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 2 entries
             Zygote Zygote
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    IL1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1722
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL1A (see all 20): 
              Alzheimer's Disease in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL1A
    OriGene qSTAR qPCR primer pairs in human, mouse for IL1A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL1A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il1a1 , 5 interleukin 1 alpha1, 5 74.59(n)1
    62.26(a)1
      2 (62.90 cM)5
    161751  NM_010554.41  NP_034684.21 
     1292996105 


    ENSEMBL Gene Tree for IL1A (if available)
    TreeFam Gene Tree for IL1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL1A (see all 298)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15167891,2
    C,F,A--105985600(+) CAAGCC/TTCCCG 1 -- ds50017Minor allele frequency- T:0.23NS NA CSA EA 288
    rs593819331,2
    C--105985605(+) CTCCCA/GAGTAG 1 -- ds50010--------
    rs37835551,2
    C,F,A--105985669(-) CTACAA/GAAAAA 1 -- ds50015Minor allele frequency- G:0.35NS NA WA CSA 95
    rs1864236371,2
    --105985715(+) GAACTC/GCTGAC 1 -- ds50010--------
    rs1896989191,2
    --105985742(+) ACCTTG/TGCCTC 1 -- ds50010--------
    rs1822086471,2
    --105985811(+) TGTAGC/GTCTGT 1 -- ds50010--------
    rs15167901,2
    C,F,A--105985867(+) GTAATG/ATGAGC 1 -- ds500110Minor allele frequency- A:0.31NS MN NA WA CSA EA 550
    rs1426064871,2
    --105985929(+) GCAGCC/TAACAA 1 -- ds50010--------
    rs1868559101,2
    --105985945(+) AGAAAA/CAAATA 1 -- ds50010--------
    rs1914861331,2
    --105985982(+) TAACAA/CTAAAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for IL1A (113531492 - 113542971 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for IL1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720541CNV Deletion23290073
    esv2720542CNV Deletion23290073
    esv2720540CNV Deletion23290073
    esv2720538CNV Deletion23290073
    esv2720544CNV Deletion23290073
    esv2720543CNV Deletion23290073
    esv2518569CNV Deletion19546169

    Human Gene Mutation Database (HGMD): IL1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL1A
    DNA2.0 Custom Variant and Variant Library Synthesis for IL1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147760    OMIM disorders: --

    Selected diseases for IL1A (see all 304):    About MalaCards
    nephropathia epidemica    acute hemorrhagic conjunctivitis    aggressive periodontitis    cholesteatoma
    multidrug-resistant tuberculosis    periodontal disease    gingival recession    keratopathy
    irritant dermatitis    bullous keratopathy    schnitzler syndrome    periodontitis
    gingivitis    pulpitis    stachybotrys chartarum    silicosis
    intervertebral disc disease    middle ear cholesteatoma    tonsillitis    classic kaposi sarcoma

    7 diseases from the University of Copenhagen DISEASES database for IL1A:
    Arthritis     Periodontitis     Skin disease     Cancer
    Lung disease     Hypersensitivity reaction type II disease     Vascular disease

    IL1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for IL1A gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 88.1 1482 10469303 (4), 8094760 (3), 8562975 (3), 1601744 (3) (see all 99)
    tumors 75.1 1369 9373735 (6), 11871814 (5), 9216708 (5), 14581361 (4) (see all 99)
    inflammation 71.1 131 19839011 (3), 17043764 (2), 16530403 (2), 19050234 (2) (see all 99)
    rheumatoid arthritis 57.6 44 8782124 (2), 1863828 (2), 2398274 (2), 1458286 (2) (see all 32)
    periodontal diseases 49.9 17 11145356 (6), 11480049 (1), 11846196 (1), 2141875 (1) (see all 9)
    response acute phase 47.7 3 2174352 (1), 9379320 (1), 15271788 (1)
    cholesteatoma middle ear 47.3 7 8583857 (2), 9115708 (1), 8369082 (1), 12768791 (1)
    osteoarthritis 45.5 13 9283970 (2), 11511685 (1), 10229398 (1), 16278818 (1) (see all 9)
    psoriasis 41.9 20 1903629 (5), 9858135 (2), 2258628 (2), 2191038 (1) (see all 10)
    chronic periodontitis 41.6 5 16642902 (1), 16708852 (1), 17093844 (1), 16838563 (1)

    Genetic Association Database (GAD): IL1A
    Human Genome Epidemiology (HuGE) Navigator: IL1A (507 documents)

    Export disorders for IL1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL1A gene, integrated from 10 sources (see all 2883):
    (articles sorted by number of sources associating them with IL1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. (PubMed id 2989698)1, 2, 3 March C.J.... Cosman D. (Nature 1985)
    2. Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease. (PubMed id 11145356)1, 4, 9 Shirodaria S....Hughes F.J. (J. Dent. Res. 2000)
    3. Relationship between IL-1A polymorphisms and gingival overgrowth in renal transplant recipients receiving Cyclosporin A. (PubMed id 16965524)1, 4, 9 Bostanci N....McKay I.J. (J. Clin. Periodontol. 2006)
    4. Correlation of IL-1alpha and IL-4 gene polymorphisms and clinical parameters in idiopathic pulmonary fibrosis. (PubMed id 17309781)1, 4, 9 Vasakova M....Sulc J. (Scand. J. Immunol. 2007)
    5. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (PubMed id 16719905)1, 4, 9 SA!nchez E....Koeleman B.P. (BMC Med. Genet. 2006)
    6. Interleukin 1 and nuclear factor-kappaB polymorphisms in ankylosing spondylitis in Canada and Korea. (PubMed id 16206345)1, 4, 9 Kim T.H....Inman R.D. (J. Rheumatol. 2005)
    7. A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. (PubMed id 8188271)1, 3, 9 Nicklin M.J.H.... Duff G.W. (Genomics 1994)
    8. Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders. (PubMed id 18832862)1, 4, 9 Misener V.L....Barr C.L. (Neuropsychobiology 2008)
    9. Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients. (PubMed id 17716546)1, 4, 9 Sezgin M....Sahin G. (Clin Invest Med 2007)
    10. Interleukin-1 gene cluster polymorphism in chagas disease in a Colombian case-control study. (PubMed id 17002905)1, 4, 9 FlA^rez O....GonzA!lez C.I. (Hum. Immunol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3552 HGNC: 5991 AceView: IL1A Ensembl:ENSG00000115008 euGenes: HUgn3552
    ECgene: IL1A Kegg: 3552 H-InvDB: IL1A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL1A Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1
    SeattleSNPshttp://pga.gs.washington.edu/data/il1a/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL1A gene:
    Search GeneIP for patents involving IL1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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