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Aliases for IL1A Gene

Aliases for IL1A Gene

  • Interleukin 1, Alpha 2 3
  • Hematopoietin-1 2 3 4
  • Pro-Interleukin-1-Alpha 2 3
  • Preinterleukin 1 Alpha 2 3
  • IL-1 Alpha 3 4
  • IL1F1 3 4
  • Interleukin-1 Alpha 3
  • IL1-ALPHA 3
  • IL-1A 3
  • IL1 3

External Ids for IL1A Gene

Previous HGNC Symbols for IL1A Gene

  • IL1

Previous GeneCards Identifiers for IL1A Gene

  • GC02M110737
  • GC02M111452
  • GC02M113438
  • GC02M113626
  • GC02M113247
  • GC02M105986
  • GC02M113531

Summaries for IL1A Gene

Entrez Gene Summary for IL1A Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1A Gene

IL1A (Interleukin 1, Alpha) is a Protein Coding gene. Diseases associated with IL1A include skin conditions and acute hemorrhagic conjunctivitis. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding.

UniProtKB/Swiss-Prot for IL1A Gene

  • Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells

Tocris Summary for IL1A Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1A Gene

Genomics for IL1A Gene

Regulatory Elements for IL1A Gene

Genomic Location for IL1A Gene

Start:
112,773,915 bp from pter
End:
112,785,394 bp from pter
Size:
11,480 bases
Orientation:
Minus strand

Genomic View for IL1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1A Gene

Proteins for IL1A Gene

  • Protein details for IL1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01583-IL1A_HUMAN
    Recommended name:
    Interleukin-1 alpha
    Protein Accession:
    P01583
    Secondary Accessions:
    • Q53QF9
    • Q7RU02

    Protein attributes for IL1A Gene

    Size:
    271 amino acids
    Molecular mass:
    30607 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for IL1A Gene

neXtProt entry for IL1A Gene

Proteomics data for IL1A Gene at MOPED

Post-translational modifications for IL1A Gene

  • Glycosylation at Asn102 and Asn141
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL1A (IL-1 alpha/IL-1F1)

Protein Products

No data available for DME Specific Peptides for IL1A Gene

Domains for IL1A Gene

Gene Families for IL1A Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • IL :Interleukins and interleukin receptors

Suggested Antigen Peptide Sequences for IL1A Gene

Graphical View of Domain Structure for InterPro Entry

P01583

UniProtKB/Swiss-Prot:

IL1A_HUMAN :
  • P01583
Domain:
  • The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL1A: view

Function for IL1A Gene

Molecular function for IL1A Gene

GENATLAS Biochemistry: interleukin 1,alpha polypeptide,mainly expressed by macrophage,involved in the inflammatory response
UniProtKB/Swiss-Prot Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells

Gene Ontology (GO) - Molecular Function for IL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IMP 2989698
GO:0005149 interleukin-1 receptor binding IEA --
GO:0005507 copper ion binding IDA 12746488
GO:0005515 protein binding IPI 12746488
genes like me logo Genes that share ontologies with IL1A: view
genes like me logo Genes that share phenotypes with IL1A: view

Animal Model Products

CRISPR Products

miRNA for IL1A Gene

miRTarBase miRNAs that target IL1A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IL1A Gene

Localization for IL1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1A Gene

Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1A Gene COMPARTMENTS Subcellular localization image for IL1A gene
Compartment Confidence
cytosol 5
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IMP 3493774
GO:0005829 cytosol IDA 12746488
genes like me logo Genes that share ontologies with IL1A: view

Pathways for IL1A Gene

genes like me logo Genes that share pathways with IL1A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001660 fever generation IEA --
GO:0002248 connective tissue replacement involved in inflammatory response wound healing IEA --
GO:0006915 apoptotic process TAS 1924307
GO:0006954 inflammatory response TAS 6209582
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with IL1A: view

Compounds for IL1A Gene

(5) Tocris Compounds for IL1A Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
SC 144 hydrochloride gp130 inhibitor; blocks cytokine-triggered gp130 signaling [917497-70-2]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(142) Novoseek inferred chemical compound relationships for IL1A Gene

Compound -log(P) Hits PubMed IDs
pge2 74.5 178
rantes 68.9 82
cycloheximide 62 21
endotoxin 59.5 65
il 10 57.7 23
genes like me logo Genes that share compounds with IL1A: view

Transcripts for IL1A Gene

mRNA/cDNA for IL1A Gene

(56) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1A Gene

Interleukin 1, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1A Gene

No ASD Table

Relevant External Links for IL1A Gene

GeneLoc Exon Structure for
IL1A
ECgene alternative splicing isoforms for
IL1A

Expression for IL1A Gene

mRNA expression in normal human tissues for IL1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1A Gene

This gene is overexpressed in Esophagus - Mucosa (20.4), Testis (7.4), and Minor Salivary Gland (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL1A Gene

SOURCE GeneReport for Unigene cluster for IL1A Gene Hs.1722

genes like me logo Genes that share expressions with IL1A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL1A Gene

Orthologs for IL1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1A 35
  • 99.88 (n)
  • 100 (a)
IL1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL1A 35
  • 82.21 (n)
  • 73.31 (a)
IL1A 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1A 35
  • 82.13 (n)
  • 72.24 (a)
IL1A 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1a 35
  • 74.59 (n)
  • 62.26 (a)
Il1a 16
Il1a 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1A 36
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1a 35
  • 74.59 (n)
  • 65.28 (a)
Species with no ortholog for IL1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1A Gene

ENSEMBL:
Gene Tree for IL1A (if available)
TreeFam:
Gene Tree for IL1A (if available)

Paralogs for IL1A Gene

No data available for Paralogs for IL1A Gene

Variants for IL1A Gene

Sequence variations from dbSNP and Humsavar for IL1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs697 -- 112,780,976(-) gtggc(A/G)caatc intron-variant
rs16347 -- 112,774,142(+) TTGAA(-/TGAA)ACAAG utr-variant-3-prime
rs17561 - 112,779,646(-) GGTCA(G/T)CACCT reference, missense
rs17562 - 112,779,613(-) AATAC(A/G)ACTTT reference, missense
rs20540 -- 112,781,647(-) TCCAT(C/T)ACTGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IL1A Gene

Variant ID Type Subtype PubMed ID
esv2720538 CNV Deletion 23290073
esv2518569 CNV Deletion 19546169
esv2720540 CNV Deletion 23290073
esv2720541 CNV Deletion 23290073
esv2720542 CNV Deletion 23290073
esv2720543 CNV Deletion 23290073
esv2720544 CNV Deletion 23290073

Relevant External Links for IL1A Gene

HapMap Linkage Disequilibrium report
IL1A
Human Gene Mutation Database (HGMD)
IL1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1A Gene

Disorders for IL1A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (42) Diseases for IL1A Gene including...

Search for IL1A Gene in MalaCards »

(96) Novoseek inferred disease relationships for IL1A Gene

Disease -log(P) Hits PubMed IDs
necrosis 88.1 189
tumors 75.1 233
inflammation 71.1 108
rheumatoid arthritis 57.6 38
periodontal diseases 49.9 14

Relevant External Links for IL1A

Genetic Association Database (GAD)
IL1A
Human Genome Epidemiology (HuGE) Navigator
IL1A
genes like me logo Genes that share disorders with IL1A: view

No data available for UniProtKB/Swiss-Prot for IL1A Gene

Publications for IL1A Gene

  1. Association of an interleukin 1 alpha polymorphism with Alzheimer's disease. (PMID: 10953177) Du Y. … Farlow M.R. (Neurology 2000) 3 23 48
  2. Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease. (PMID: 11065142) Rebeck G.W. (Neurosci. Lett. 2000) 3 23 48
  3. Genetic association studies of interleukin-1 (IL-1A and IL-1B) and interleukin-1 receptor antagonist genes and the risk of Alzheimer's disease. (PMID: 11079552) Minster R.L. … Kamboh M.I. (Ann. Neurol. 2000) 3 23 48
  4. Polymorphisms of the IL-1 gene complex in coal miners with silicosis. (PMID: 11241561) Yucesoy B. … Luster M.I. (Am. J. Ind. Med. 2001) 3 23 48
  5. Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease. (PMID: 11145356) Shirodaria S. … Hughes F.J. (J. Dent. Res. 2000) 3 23 48

Products for IL1A Gene

Sources for IL1A Gene

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