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Aliases for IL1A Gene

Aliases for IL1A Gene

  • Interleukin 1 Alpha 2 3 5
  • Hematopoietin-1 2 3 4
  • Pro-Interleukin-1-Alpha 2 3
  • Preinterleukin 1 Alpha 2 3
  • IL-1 Alpha 3 4
  • IL1F1 3 4
  • Interleukin 1, Alpha 3
  • IL1-ALPHA 3
  • IL-1A 3
  • IL1 3

External Ids for IL1A Gene

Previous HGNC Symbols for IL1A Gene

  • IL1

Previous GeneCards Identifiers for IL1A Gene

  • GC02M110737
  • GC02M111452
  • GC02M113438
  • GC02M113626
  • GC02M113247
  • GC02M105986
  • GC02M113531

Summaries for IL1A Gene

Entrez Gene Summary for IL1A Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1A Gene

IL1A (Interleukin 1 Alpha) is a Protein Coding gene. Diseases associated with IL1A include Irritant Dermatitis and Cholesteatoma Of Middle Ear. Among its related pathways are Toll-Like receptor Signaling Pathways and Interleukin-1 signaling. GO annotations related to this gene include cytokine activity and interleukin-1 receptor binding.

UniProtKB/Swiss-Prot for IL1A Gene

  • Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Tocris Summary for IL1A Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1A Gene

Genomics for IL1A Gene

Regulatory Elements for IL1A Gene

Enhancers for IL1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL1A on UCSC Golden Path with GeneCards custom track

Genomic Location for IL1A Gene

Chromosome:
2
Start:
112,773,915 bp from pter
End:
112,785,394 bp from pter
Size:
11,480 bases
Orientation:
Minus strand

Genomic View for IL1A Gene

Genes around IL1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1A Gene

Proteins for IL1A Gene

  • Protein details for IL1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01583-IL1A_HUMAN
    Recommended name:
    Interleukin-1 alpha
    Protein Accession:
    P01583
    Secondary Accessions:
    • Q53QF9
    • Q7RU02

    Protein attributes for IL1A Gene

    Size:
    271 amino acids
    Molecular mass:
    30607 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for IL1A Gene

neXtProt entry for IL1A Gene

Proteomics data for IL1A Gene at MOPED

Post-translational modifications for IL1A Gene

  • Glycosylation at Asn 102 and Asn 141
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

No data available for DME Specific Peptides for IL1A Gene

Domains & Families for IL1A Gene

Gene Families for IL1A Gene

Suggested Antigen Peptide Sequences for IL1A Gene

Graphical View of Domain Structure for InterPro Entry

P01583

UniProtKB/Swiss-Prot:

IL1A_HUMAN :
  • The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
  • Belongs to the IL-1 family.
Domain:
  • The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL1A: view

Function for IL1A Gene

Molecular function for IL1A Gene

GENATLAS Biochemistry:
interleukin 1,alpha polypeptide,mainly expressed by macrophage,involved in the inflammatory response
UniProtKB/Swiss-Prot Function:
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
genes like me logo Genes that share phenotypes with IL1A: view

Animal Models for IL1A Gene

MGI Knock Outs for IL1A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1A Gene

Localization for IL1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1A Gene

Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1A Gene COMPARTMENTS Subcellular localization image for IL1A gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IL1A Gene

Pathways & Interactions for IL1A Gene

genes like me logo Genes that share pathways with IL1A: view

SIGNOR curated interactions for IL1A Gene

Activates:

Gene Ontology (GO) - Biological Process for IL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001660 fever generation IEA --
GO:0006915 apoptotic process TAS 1924307
GO:0006954 inflammatory response IEA,TAS 6209582
GO:0006955 immune response IEA --
GO:0008285 negative regulation of cell proliferation IDA 3493774
genes like me logo Genes that share ontologies with IL1A: view

Drugs & Compounds for IL1A Gene

(83) Drugs for IL1A Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rilonacept Approved Pharma binder, Target 0
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1043
Pirfenidone Investigational Pharma TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo 45
AMG-108 Pharma 0
Gabexate mesylate Pharma Trypsin-like serine proteinases inhibitor, Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin 0

(66) Additional Compounds for IL1A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
10Z-Hymenialdisine
82005-12-7
Chicago Sky Blue 6B
2610-05-1

(5) Tocris Compounds for IL1A Gene

Compound Action Cas Number
10Z-Hymenialdisine Pan kinase inhibitor; potently inhibits MEK1 82005-12-7
Chicago Sky Blue 6B Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF 2610-05-1
Gabexate mesylate Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin 56974-61-9
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1
genes like me logo Genes that share compounds with IL1A: view

Transcripts for IL1A Gene

mRNA/cDNA for IL1A Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1A Gene

Interleukin 1, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1A Gene

No ASD Table

Relevant External Links for IL1A Gene

GeneLoc Exon Structure for
IL1A
ECgene alternative splicing isoforms for
IL1A

Expression for IL1A Gene

mRNA expression in normal human tissues for IL1A Gene

mRNA differential expression in normal tissues according to GTEx for IL1A Gene

This gene is overexpressed in Esophagus - Mucosa (x20.4), Testis (x7.4), and Minor Salivary Gland (x4.1).

Protein differential expression in normal tissues from HIPED for IL1A Gene

This gene is overexpressed in Serum (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL1A Gene



SOURCE GeneReport for Unigene cluster for IL1A Gene Hs.1722

genes like me logo Genes that share expression patterns with IL1A: view

Protein tissue co-expression partners for IL1A Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IL1A Gene

Orthologs for IL1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL1A 35
  • 82.21 (n)
  • 73.31 (a)
IL1A 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL1A 35
  • 82.13 (n)
  • 72.24 (a)
IL1A 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il1a 35
  • 74.59 (n)
  • 62.26 (a)
Il1a 16
Il1a 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL1A 35
  • 99.88 (n)
  • 100 (a)
IL1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1a 35
  • 74.59 (n)
  • 65.28 (a)
oppossum
(Monodelphis domestica)
Mammalia IL1A 36
  • 34 (a)
OneToOne
Species with no ortholog for IL1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1A Gene

ENSEMBL:
Gene Tree for IL1A (if available)
TreeFam:
Gene Tree for IL1A (if available)

Paralogs for IL1A Gene

No data available for Paralogs for IL1A Gene

Variants for IL1A Gene

Sequence variations from dbSNP and Humsavar for IL1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3783531 - 112,781,669(-) GAGAC(A/G)GTTGA reference, missense
rs17561 - 112,779,646(-) GGTCA(G/T)CACCT reference, missense
rs3783581 - 112,779,574(-) TGAAT(A/G)ACGCC reference, missense
rs17562 - 112,779,613(-) AATAC(A/G)ACTTT reference, missense
rs1801715 - 112,778,076(-) CAAAG(C/G/T)ATGAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IL1A Gene

Variant ID Type Subtype PubMed ID
esv2720538 CNV Deletion 23290073
esv2518569 CNV Deletion 19546169
esv2720540 CNV Deletion 23290073
esv2720541 CNV Deletion 23290073
esv2720542 CNV Deletion 23290073
esv2720543 CNV Deletion 23290073
esv2720544 CNV Deletion 23290073

Variation tolerance for IL1A Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL1A Gene

Human Gene Mutation Database (HGMD)
IL1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1A Gene

Disorders for IL1A Gene

MalaCards: The human disease database

(65) MalaCards diseases for IL1A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
irritant dermatitis
  • irritant contact dermatitis
cholesteatoma of middle ear
  • cholesteatoma of middle ear and mastoid
arthritis
  • inflammatory disorder of joint
acne
  • acne varioliformis
aggressive periodontitis
  • juvenile periodontitis
- elite association - COSMIC cancer census association via MalaCards
Search IL1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL1A

Genetic Association Database (GAD)
IL1A
Human Genome Epidemiology (HuGE) Navigator
IL1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL1A
genes like me logo Genes that share disorders with IL1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1A Gene

Publications for IL1A Gene

  1. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. (PMID: 2989698) March C.J. … Cosman D. (Nature 1985) 2 3 4 67
  2. Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases. (PMID: 19117745) Vasakova M. … Striz I. (Respir Med 2009) 3 23
  3. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. (PMID: 19805069) Orjalo A.V. … Campisi J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  4. Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis. (PMID: 18361934) Garrido P. … Ruiz-Cabello F. (Hum. Immunol. 2008) 3 23
  5. Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines. (PMID: 18395750) Ma J. … Manabe T. (J. Surg. Res. 2008) 3 23

Products for IL1A Gene

Sources for IL1A Gene

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