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Aliases for IL19 Gene

Aliases for IL19 Gene

  • Interleukin 19 2 3 5
  • Melanoma Differentiation Associated Protein-Like Protein 2 3
  • ZMDA1 3 4
  • NG.1 3 4
  • Melanoma Differentiation-Associated Protein-Like Protein 4
  • Interleukin-19 3
  • IL-10C 3
  • IL-19 4
  • MDA1 3

External Ids for IL19 Gene

Previous GeneCards Identifiers for IL19 Gene

  • GC01P205632
  • GC01P202682
  • GC01P203615
  • GC01P204055
  • GC01P203360
  • GC01P205038
  • GC01P206972
  • GC01P177670

Summaries for IL19 Gene

Entrez Gene Summary for IL19 Gene

  • The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL19 Gene

IL19 (Interleukin 19) is a Protein Coding gene. Diseases associated with IL19 include Spongiotic Dermatitis and Psoriasis. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.

UniProtKB/Swiss-Prot for IL19 Gene

  • May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL19 Gene

Genomics for IL19 Gene

Regulatory Elements for IL19 Gene

Enhancers for IL19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G206768 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -27.9 -27946 4.6 HDGF PKNOX1 ATF1 YY1 TCF12 GATA2 ZNF143 JUNB TBX21 KAT8 IL19 MAPKAPK2 IL24 IL20 IL10 C4BPB RASSF5 ENSG00000284486
GH01G206917 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +124.2 124201 12.0 HDGF PKNOX1 ARNT WRNIP1 SIN3A YBX1 ZNF2 ZBTB7B YY1 ZNF766 MAPKAPK2 ENSG00000271680 CDCA4P4 PIGR FCAMR IL20 IL19 FCMR IKBKE RASSF5
GH01G206859 1.2 FANTOM5 Ensembl 16.8 +60.4 60431 0.6 HDGF HDAC1 PKNOX1 SIN3A KLF17 ARID4B ZBTB40 YY1 SP3 NFYC IL19 MAPKAPK2 IL24 PIGR FCAMR RASSF5 CD55 DYRK3 IKBKE IL20
GH01G206722 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -75.2 -75183 2.2 TBP SIN3A BRCA1 RAD21 RFX5 YY1 RCOR1 FOS ZHX1 DEK MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 GC01M206749
GH01G206757 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -41.1 -41148 1.1 BCOR CTCF ASH2L ZMYM3 ZBTB40 ARID3A POLR2A EED ETV6 RELB IL19 IL24 IL20 FCMR IL10 IKBKE RASSF5 LOC105372877 GC01M206760
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL19 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL19 Gene

Chromosome:
1
Start:
206,798,870 bp from pter
End:
206,842,981 bp from pter
Size:
44,112 bases
Orientation:
Plus strand

Genomic View for IL19 Gene

Genes around IL19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL19 Gene

Proteins for IL19 Gene

  • Protein details for IL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHD0-IL19_HUMAN
    Recommended name:
    Interleukin-19
    Protein Accession:
    Q9UHD0
    Secondary Accessions:
    • B6VEV9
    • Q5VUT3
    • Q96QR4
    • Q9NUA0

    Protein attributes for IL19 Gene

    Size:
    177 amino acids
    Molecular mass:
    20452 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL19 Gene

    Alternative splice isoforms for IL19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL19 Gene

Post-translational modifications for IL19 Gene

  • Glycosylation at isoforms=2, 356 and posLast=135135

Other Protein References for IL19 Gene

Antibody Products

  • Abcam antibodies for IL19
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL19

Protein Products

  • Abcam proteins for IL19

No data available for DME Specific Peptides for IL19 Gene

Domains & Families for IL19 Gene

Gene Families for IL19 Gene

Suggested Antigen Peptide Sequences for IL19 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHD0

UniProtKB/Swiss-Prot:

IL19_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL19: view

Function for IL19 Gene

Molecular function for IL19 Gene

UniProtKB/Swiss-Prot Function:
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

Gene Ontology (GO) - Molecular Function for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 11196675
genes like me logo Genes that share ontologies with IL19: view
genes like me logo Genes that share phenotypes with IL19: view

Animal Models for IL19 Gene

MGI Knock Outs for IL19:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL19

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL19 Gene

Localization for IL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL19 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL19: view

Pathways & Interactions for IL19 Gene

genes like me logo Genes that share pathways with IL19: view

SIGNOR curated interactions for IL19 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006955 immune response NAS 11196675
GO:0007165 signal transduction NAS 11196675
GO:0042226 interleukin-6 biosynthetic process IEA --
GO:0072593 reactive oxygen species metabolic process IEA --
genes like me logo Genes that share ontologies with IL19: view

Drugs & Compounds for IL19 Gene

(2) Drugs for IL19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL19: view

Transcripts for IL19 Gene

mRNA/cDNA for IL19 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL19 Gene

Interleukin 19:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL19 Gene

No ASD Table

Relevant External Links for IL19 Gene

GeneLoc Exon Structure for
IL19
ECgene alternative splicing isoforms for
IL19

Expression for IL19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL19 Gene

mRNA differential expression in normal tissues according to GTEx for IL19 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.8), Minor Salivary Gland (x13.2), and Stomach (x9.7).

Protein differential expression in normal tissues from HIPED for IL19 Gene

This gene is overexpressed in Milk (53.4) and Cervix (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL19 Gene



Protein tissue co-expression partners for IL19 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL19 Gene:

IL19

SOURCE GeneReport for Unigene cluster for IL19 Gene:

Hs.661017
genes like me logo Genes that share expression patterns with IL19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL19 Gene

Orthologs for IL19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL19 34 35
  • 97.98 (n)
dog
(Canis familiaris)
Mammalia IL19 34 35
  • 84.88 (n)
cow
(Bos Taurus)
Mammalia IL19 34 35
  • 83.43 (n)
mouse
(Mus musculus)
Mammalia Il19 34 16 35
  • 78.43 (n)
rat
(Rattus norvegicus)
Mammalia Il19 34
  • 77.91 (n)
oppossum
(Monodelphis domestica)
Mammalia IL19 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL19 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL19 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il19l 35
  • 24 (a)
OneToMany
Species where no ortholog for IL19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL19 Gene

ENSEMBL:
Gene Tree for IL19 (if available)
TreeFam:
Gene Tree for IL19 (if available)

Paralogs for IL19 Gene

Paralogs for IL19 Gene

(1) SIMAP similar genes for IL19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL19: view

Variants for IL19 Gene

Sequence variations from dbSNP and Humsavar for IL19 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000012281 -- 206,829,586(+) GCTGT(-/G)GGGAG intron-variant
rs1000056725 -- 206,835,192(+) AGTTA(A/C)CTTGT intron-variant
rs1000109959 -- 206,835,493(+) AGCTG(C/G)GAATC intron-variant
rs1000127192 -- 206,834,064(+) CTAAG(C/T)TGGAT intron-variant, utr-variant-5-prime
rs1000212056 -- 206,824,004(+) AGAAT(A/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL19 Gene

Variant ID Type Subtype PubMed ID
esv1601718 CNV insertion 17803354
esv3407405 CNV insertion 20981092
esv997006 CNV deletion 20482838

Variation tolerance for IL19 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL19 Gene

Human Gene Mutation Database (HGMD)
IL19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL19 Gene

Disorders for IL19 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IL19 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spongiotic dermatitis
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search IL19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL19

Genetic Association Database (GAD)
IL19
Human Genome Epidemiology (HuGE) Navigator
IL19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL19
genes like me logo Genes that share disorders with IL19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL19 Gene

Publications for IL19 Gene

  1. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homolog of human interleukin-10 (IL-10). (PMID: 11196675) Gallagher G. … Kotenko S.V. (Genes Immun. 2000) 2 3 4 22 64
  2. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T. … KA/ks S. (BMC Med. Genet. 2008) 3 22 46 64
  3. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K. … Silm H. (Br. J. Dermatol. 2007) 3 22 46 64
  4. Association of interleukin-19 gene polymorphisms with age. (PMID: 17522354) Okayama N. … Hinoda Y. (J. Gerontol. A Biol. Sci. Med. Sci. 2007) 3 22 46 64
  5. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PMID: 15815689) Oleksyk T.K. … Smith M.W. (Genes Immun. 2005) 3 22 46 64

Products for IL19 Gene

Sources for IL19 Gene

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