Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IL19 Gene

protein-coding   GIFtS: 57
GCID: GC01P206972

Interleukin 19

  See IL19-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Interleukin 191 2     IL-10C2
Melanoma Differentiation Associated Protein-Like Protein1 2     MDA12
Melanoma Differentiation-Associated Protein-Like Protein2 3     interleukin-192
NG.12 3     IL-193
ZMDA12 3     

External Ids:    HGNC: 59901   Entrez Gene: 299492   Ensembl: ENSG000001422247   OMIM: 6056875   UniProtKB: Q9UHD03   

Export aliases for IL19 gene to outside databases

Previous GC identifers: GC01P205632 GC01P202682 GC01P203615 GC01P204055 GC01P203360 GC01P205038 GC01P177670


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IL19 Gene:
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found
to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of
the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to
up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in
inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been
described. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL19 Gene:
IL19 (interleukin 19) is a protein-coding gene. Diseases associated with IL19 include melanoma, and richter's syndrome. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.

UniProtKB/Swiss-Prot: IL19_HUMAN, Q9UHD0
Function: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces
apoptosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL19 gene promoter:
         GR   GCNF   GR-beta   CUTL1   CREB   deltaCREB   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL19 promoter sequence
   Search Chromatin IP Primers for IL19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.2

IL19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL19 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206972:  view genomic region     (about GC identifiers)

Start:
206,972,215 bp from pter      End:
207,016,326 bp from pter
Size:
44,112 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IL19_HUMAN, Q9UHD0 (See protein sequence)
Recommended Name: Interleukin-19 precursor  
Size: 177 amino acids; 20452 Da
1 PDB 3D structure from and Proteopedia for IL19:
1N1F (3D)    
Secondary accessions: Q5VUT3 Q96QR4 Q9NUA0
Alternative splicing: 2 isoforms:  Q9UHD0-1   Q9UHD0-2   

Explore the universe of human proteins at neXtProt for IL19: NX_Q9UHD0

Explore proteomics data for IL19 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn135

  • See IL19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_037503.2  NP_715639.1  

    ENSEMBL proteins: 
     ENSP00000343000   ENSP00000270218  

    IL19 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL19 (IL-19)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL19
    OriGene Protein Over-expression Lysate for IL19
    OriGene MassSpec for IL19
    OriGene Custom Protein Services for IL19
    GenScript Purified and Recombinant Proteins for IL19
    Novus Biologicals IL19 Proteins
    Novus Biologicals IL19 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL19
    Cloud-Clone Corp. Proteins for IL19

     
    Search eBioscience for Proteins for IL19 

     
    antibodies-online proteins for IL19 (44 products) 

     
    antibodies-online peptides for IL19

    IL19 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL19 (IL-19)
    OriGene Antibodies for IL19
    OriGene Custom Antibody Services for IL19
    Novus Biologicals IL19 Antibodies
    Abcam antibodies for IL19
    Cloud-Clone Corp. Antibodies for IL19
    ThermoFisher Antibodies for IL19
    antibodies-online antibodies for IL19 (55 products) 

    IL19 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL19
    R&D Systems ELISAs for IL19 (IL-19)         (see all)
    GenScript Custom Assay Services for IL19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL19
    Cloud-Clone Corp. CLIAs for IL19
    Search eBioscience for ELISAs for IL19 
    antibodies-online kits for IL19 (21 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR020421 IL-19
     IPR012351 4_helix_cytokine_core
     IPR020423 IL-10_CS
     IPR009079 4_helix_cytokine-like_core
     IPR020443 IL-10/19/20/24/26_fam

    Graphical View of Domain Structure for InterPro Entry Q9UHD0

    ProtoNet protein and cluster: Q9UHD0

    1 Blocks protein domain: IPB000098 Interleukin-10

    UniProtKB/Swiss-Prot: IL19_HUMAN, Q9UHD0
    Similarity: Belongs to the IL-10 family


    Find genes that share domains with IL19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL19_HUMAN, Q9UHD0
    Function: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces
    apoptosis (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity TAS11196675
         
    Find genes that share ontologies with IL19           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL19:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Il19):
     homeostasis/metabolism 

    Find genes that share phenotypes with IL19           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il19tm1Dnax for IL19

       genOway: Develop your customized and physiologically relevant rodent model for IL19

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL19 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL19
    SwitchGear 3'UTR luciferase reporter plasmidIL19 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL19
    Predesigned siRNA for gene silencing in human, mouse, rat IL19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL19

    Clone
    Products:
         
    OriGene clones in human, mouse for IL19 (see all 10)
    OriGene ORF clones in mouse, rat for IL19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL19 (NM_153758)
    Sino Biological Human cDNA Clone for IL19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL19

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL19
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL19 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IL19_HUMAN, Q9UHD0: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11196675
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IL19 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with IL19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL19 (see all 24)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    1 BioSystems Pathway for IL19
        IL23-mediated signaling events



    2 Kegg Pathways  (Kegg details for IL19):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL19: 
              Oxidative Stress in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for IL19 (Q9UHD03 ENSP000003430004) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL20RAQ9UHF43, ENSP000003149764I2D: score=1 STRING: ENSP00000314976
    IL20RBQ6UXL03I2D: score=1 
    IL12BENSP000002312284STRING: ENSP00000231228
    IL23AENSP000002285344STRING: ENSP00000228534
    TYK2ENSP000002648184STRING: ENSP00000264818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006955immune response NAS11196675
    GO:0007165signal transduction NAS11196675
    GO:0042226interleukin-6 biosynthetic process IEA--
    GO:0072593reactive oxygen species metabolic process IEA--

    Find genes that share ontologies with IL19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL19

    3 Novoseek inferred chemical compound relationships for IL19 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 10 77.1 9 16943796 (2), 15815689 (1), 18717682 (1)
    calcipotriol 51.4 4 14675174 (3), 16225599 (1)
    cyclosporin a 0 3 14675174 (3)



    Find genes that share compounds with IL19           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IL19 gene (2 alternative transcripts): 
    NM_013371.3  NM_153758.2  

    Unigene Cluster for IL19:

    Interleukin 19
    Hs.661017  [show with all ESTs]
    Unigene Representative Sequence: NM_013371
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340758(uc001heo.3) ENST00000270218(uc001hep.3) ENST00000476097(uc010prx.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL19 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL19
    SwitchGear 3'UTR luciferase reporter plasmidIL19 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL19
    Predesigned siRNA for gene silencing in human, mouse, rat IL19
    Clone
    Products:
         
    OriGene clones in human, mouse for IL19 (see all 10)
    OriGene ORF clones in mouse, rat for IL19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL19 (NM_153758)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL19
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL19
    OriGene qSTAR qPCR primer pairs in human, mouse for IL19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL19
      QuantiTect SYBR Green Assays in human, mouse, rat IL19
      QuantiFast Probe-based Assays in human, mouse, rat IL19

    Additional mRNA sequence: 

    AF192498.1 AF453946.1 AY040367.1 FJ380053.1 

    2 DOTS entries:

    DT.207952  DT.95299344 

    13 AceView cDNA sequences:

    NM_153758 NM_013371 AY040367 AF453946 AF192498 CD366952 CA309757 AI266722 
    CA306526 AA151652 BX096099 AA151656 AA151733 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IL19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTGATGT
    IL19 Expression
    About this image

    IL19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661017
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL19: 
              Oxidative Stress in human mouse rat
              Common Cytokines in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL19
    OriGene qSTAR qPCR primer pairs in human, mouse for IL19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL19
    QuantiTect SYBR Green Assays in human, mouse, rat IL19
    QuantiFast Probe-based Assays in human, mouse, rat IL19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IL19 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il191 , 5 interleukin 191, 5 78.43(n)1
    70(a)1
      1 (56.89 cM)5
    3292441  NM_001009940.11  NP_001009940.11 
     1309326565 
    chicken
    (Gallus gallus)
    Aves IL196
    interleukin 19
    42(a)
    1 ↔ 1
    26(2517673-2519712)
    zebrafish
    (Danio rerio)
    Actinopterygii il19l6
    interleukin 19 like
    24(a)
    1 → many
    11(21929540-21932984) ENSDARG00000090344


    ENSEMBL Gene Tree for IL19 (if available)
    TreeFam Gene Tree for IL19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IL19 gene
    IL202  IL242  
    1 SIMAP similar gene for IL19 using alignment to 2 protein entries:     IL19_HUMAN (see all proteins):
    IL20

    Find genes that share paralogs with IL19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IL19 (see all 939)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867932651,2
    --206970279(+) GTCCAG/TCCCAG 1 -- us2k10--------
    rs1430345261,2
    C--206970340(+) GAAAAC/GCGGAT 1 -- us2k10--------
    rs1895944031,2
    --206970406(+) CCTGAC/TTCCTT 1 -- us2k10--------
    rs727569481,2
    C,F--206970443(+) GGCTCA/GCTCCC 1 -- us2k15Minor allele frequency- G:0.18NA CSA WA 244
    rs48451401,2
    C,F,A,H--206970470(+) TGCTGC/TGGGAC 1 -- us2k120Minor allele frequency- T:0.05NS EA NA CSA WA 2124
    rs1474510861,2
    C--206970546(+) CAATCA/GTTGCC 1 -- us2k10--------
    rs112805881,2
    C--206970628(+) TGGTGTAGAA   
       TTC
    /-
    TAGAA
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs340382971,2
    C--206970629(+) ATTCT-/AGAATTC
    T
    /TAGAATTC
    CAGGC
    1 -- us2k11NA 2
    rs1811881841,2
    C--206970781(+) ACCTCC/TGAGAG 1 -- us2k10--------
    rs1853817591,2
    --206970785(+) CCGAGA/GGTTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL19 (206972215 - 207016326 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL19:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997006CNV Deletion20482838
    esv1601718CNV Insertion17803354

    Human Gene Mutation Database (HGMD): IL19
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL19
    DNA2.0 Custom Variant and Variant Library Synthesis for IL19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605687    OMIM disorders: --

    2 diseases for IL19:    
    About MalaCards
    melanoma    richter's syndrome


    Find genes that share disorders with IL19           About GenesLikeMe

    7 Novoseek inferred disease relationships for IL19 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 70 21 16120148 (4), 16225599 (3), 15496954 (3), 17263806 (1) (see all 9)
    inflammation 38.4 4 17263806 (1), 19834971 (1), 18021895 (1), 20001767 (1)
    melanoma 24.5 6 12370360 (1), 15557163 (1), 11564763 (1), 11929132 (1)
    hyperplasia 17.9 2 18397956 (1), 18669613 (1)
    asthma 0 10 15557163 (3), 18539194 (2)
    necrosis 0 2 18021895 (1), 17449492 (1)
    tumors 0 8 18809337 (2), 16731153 (1), 12351624 (1), 18021895 (1)

    Genetic Association Database (GAD): IL19
    Human Genome Epidemiology (HuGE) Navigator: IL19 (24 documents)

    Export disorders for IL19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IL19 gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with IL19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homolog of human interleukin-10 (IL-10). (PubMed id 11196675)1, 2, 3, 9 Gallagher G....Kotenko S.V. (Genes Immun. 2000)
    2. IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha. (PubMed id 12370360)1, 2, 9 Liao Y.-C.... Chang M.-S. (J. Immunol. 2002)
    3. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PubMed id 17263806)1, 4, 9 Kingo K....Silm H. (Br. J. Dermatol. 2007)
    4. Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. (PubMed id 12403790)1, 2, 9 Chang C.... Zdanov A. (J. Biol. Chem. 2003)
    5. Association of interleukin-19 gene polymorphisms with age. (PubMed id 17522354)1, 4, 9 Okayama N....Hinoda Y. (J. Gerontol. A Biol. Sci. Med. Sci. 2007)
    6. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PubMed id 19087313)1, 4, 9 Traks T....KA/ks S. (BMC Med. Genet. 2008)
    7. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PubMed id 15815689)1, 4, 9 Oleksyk T.K....Smith M.W. (Genes Immun. 2005)
    8. Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism. (PubMed id 20603037)1, 4 Beckers M.M....Biesma D.H. (Eur. J. Intern. Med. 2010)
    9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29949 HGNC: 5990 AceView: IL19 Ensembl:ENSG00000142224 euGenes: HUgn29949
    ECgene: IL19 Kegg: 29949 H-InvDB: IL19

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IL19 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il19/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IL19 gene:
    Search GeneIP for patents involving IL19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for IL19 (IL-19)   Browse Cell Culture Products  
     ELISAs for IL19 (IL-19)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for IL19 (IL-19)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for IL19 (IL-19)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for IL19 (IL-19)  
     OriGene Antibodies for IL19   OriGene RNAi products in human, mouse, rat for IL19  
     OriGene qPCR primer pairs and template standards for IL19   OriGene Protein Over-expression Lysate for IL19  
     OriGene MassSpec for IL19   OriGene clones in human, mouse for IL19  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL19   OriGene Purified Protein for IL19  
     OriGene ORF clones in mouse, rat for IL19   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL19   OriGene Custom Protein Services for IL19  

     
     
     Block miRNA regulation of human, mouse, rat IL19 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IL19
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL19 Predesigned siRNA for gene silencing in human, mouse, rat IL19
     QuantiFast Probe-based Assays in human, mouse, rat IL19 QuantiTect SYBR Green Assays in human, mouse, rat IL19
     PCR Arrays including human, mouse, rat IL19 Search Chromatin IP Primers for IL19
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL19  GeneGlobe Interaction Network for IL19
     Regulatory tfbs in IL19 promoter
     GenScript Purified and Recombinant Proteins for IL19 GenScript cDNA clones with any tag delivered in your preferred vector for IL19
     GenScript Custom Assay Services for IL19 GenScript Custom overexpressing Cell Line Services for IL19
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IL19
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IL19
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IL19 antibodies
     IL19 proteins
     IL19 lysates
     Antibodies for IL19
     See all of Abcam's Antibodies, Kits and Proteins for IL19
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for IL19
     Proteins for IL19
     Antibodies for IL19
     ELISAs for IL19
     CLIAs for IL19



     Browse ESI BIO Cell Lines and PureStem Progenitors for IL19
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL19
     SwitchGear 3'UTR luciferase reporter plasmids for IL19
     SwitchGear Promoter luciferase reporter plasmids for IL19
     ThermoFisher Antibodies for IL19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL19
     Browse compounds at ApexBio
     Search Addgene for plasmids for IL19
      Search eBioscience for proteins for IL19
      Search eBioscience for elisas for IL19
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for IL19
     antibodies-online antibodies for IL19 (55 products)
     antibodies-online kits for IL19 (21 products)
     antibodies-online peptides for IL19
     antibodies-online proteins for IL19 (44 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL19 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4