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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL19 Gene

protein-coding   GIFtS: 57
GCID: GC01P206972

Interleukin 19

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 191 2     IL-10C2
Melanoma Differentiation Associated Protein-Like Protein1 2     MDA12
Melanoma Differentiation-Associated Protein-Like Protein2 3     interleukin-192
NG.12 3     IL-193
ZMDA12 3     

External Ids:    HGNC: 59901   Entrez Gene: 299492   Ensembl: ENSG000001422247   OMIM: 6056875   UniProtKB: Q9UHD03   

Export aliases for IL19 gene to outside databases

Previous GC identifers: GC01P205632 GC01P202682 GC01P203615 GC01P204055 GC01P203360 GC01P205038 GC01P177670


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL19 Gene:
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found
to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of
the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to
up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in
inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been
described. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL19 Gene: 
IL19 (interleukin 19) is a protein-coding gene. Diseases associated with IL19 include melanoma, and major depressive disorder, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.

UniProtKB/Swiss-Prot: IL19_HUMAN, Q9UHD0
Function: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces
apoptosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL19 gene promoter:
         GR   GCNF   GR-beta   CUTL1   CREB   deltaCREB   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL19 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.2

IL19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL19 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206972:  view genomic region     (about GC identifiers)

Start:
206,972,215 bp from pter      End:
207,016,326 bp from pter
Size:
44,112 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL19_HUMAN, Q9UHD0 (See protein sequence)
Recommended Name: Interleukin-19 precursor  
Size: 177 amino acids; 20452 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for IL19:
1N1F (3D)    
Secondary accessions: Q5VUT3 Q96QR4 Q9NUA0
Alternative splicing: 2 isoforms:  Q9UHD0-1   Q9UHD0-2   

Explore the universe of human proteins at neXtProt for IL19: NX_Q9UHD0

Explore proteomics data for IL19 at MOPED 

IL19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL19 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_037503.2  NP_715639.1  

ENSEMBL proteins: 
 ENSP00000343000   ENSP00000270218  

Human Recombinant Protein Products for IL19: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL19 (IL-19)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for IL19
OriGene Protein Over-expression Lysate for IL19
OriGene MassSpec for IL19 
OriGene Custom Protein Services for IL19
GenScript Purified and Recombinant Proteins for IL19
Novus Biologicals IL19 Proteins
Novus Biologicals IL19 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for IL19
Cloud-Clone Corp. Proteins for IL19 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS11196675
GO:0005615extracellular space IEA--

IL19 for ontologies           About GeneDecksing



IL19 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IL19 (IL-19)
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Novus Biologicals IL19 Antibodies
Abcam antibodies for IL19
Cloud-Clone Corp. Antibodies for IL19 
ThermoFisher Antibodies for IL19
LSBio Antibodies in human, mouse, rat for IL19 

Assay Products for IL19: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL19
R&D Systems ELISAs for IL19 (IL-19)         (see all)
GenScript Custom Assay Services for IL19
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL19 
Cloud-Clone Corp. CLIAs for IL19


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

5 InterPro protein domains:
 IPR020421 Interleukin-19
 IPR012351 4_helix_cytokine_core
 IPR020423 Interleukin-10_CS
 IPR009079 4_helix_cytokine-like_core
 IPR020443 Interleukin-10/19/20/24

Graphical View of Domain Structure for InterPro Entry Q9UHD0

ProtoNet protein and cluster: Q9UHD0

1 Blocks protein domain: IPB000098 Interleukin-10

UniProtKB/Swiss-Prot: IL19_HUMAN, Q9UHD0
Similarity: Belongs to the IL-10 family


IL19 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL19_HUMAN, Q9UHD0
Function: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces
apoptosis (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity TAS11196675
     
IL19 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IL19:
 Increased cell death HMECs cel 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Il19):
 homeostasis/metabolism 

IL19 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Il19tm1Dnax for IL19

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL19 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL19

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL19 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL19 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL19
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL19
SwitchGear 3'UTR luciferase reporter plasmidIL19 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL19

Gene Editing
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DNA2.0 Custom Protein Engineering Service for IL19
Sirion Biotech Customized adenovirus for overexpression of IL19

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL19 (see all 9)
OriGene ORF clones in mouse, rat for IL19
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): IL19 (NM_153758)
Sino Biological Human cDNA Clone for IL19
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL19
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL19
Sirion Biotech Customized lentivirus for stable overexpression of IL19 
                     Customized lentivirus expression plasmids for stable overexpression of IL19 

Cell Line
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GenScript Custom overexpressing Cell Line Services for IL19
Search LifeMap BioReagents cell lines for IL19
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL19


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL19 About   (see all 7)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
3Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
4Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
5PAK Pathway
PAK Pathway0.56
Antioxidant Action of Vitamin-C0.56

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL19 (see all 24)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Tec Kinases Signaling

1 BioSystems Pathway for IL19
    IL23-mediated signaling events



2         Kegg Pathways  (Kegg details for IL19):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway


IL19 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL19

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for IL19 (Q9UHD03 ENSP000003430004) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
IL20RAQ9UHF43, ENSP000003149764I2D: score=1 STRING: ENSP00000314976
IL20RBQ6UXL03I2D: score=1 
IL12BENSP000002312284STRING: ENSP00000231228
IL23AENSP000002285344STRING: ENSP00000228534
TYK2ENSP000002648184STRING: ENSP00000264818
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process IEA--
GO:0006955immune response NAS11196675
GO:0007165signal transduction NAS11196675
GO:0042226interleukin-6 biosynthetic process IEA--
GO:0072593reactive oxygen species metabolic process IEA--

IL19 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL19 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL19

3 Novoseek inferred chemical compound relationships for IL19 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
il 10 77.1 9 16943796 (2), 15815689 (1), 18717682 (1)
calcipotriol 51.4 4 14675174 (3), 16225599 (1)
cyclosporin a 0 3 14675174 (3)

Search CenterWatch for drugs/clinical trials and news about IL19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL19 gene (2 alternative transcripts): 
NM_013371.3  NM_153758.2  

Unigene Cluster for IL19:

Interleukin 19
Hs.661017  [show with all ESTs]
Unigene Representative Sequence: NM_013371
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340758(uc001heo.3) ENST00000270218(uc001hep.3) ENST00000476097(uc010prx.1)


miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL19
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL19
SwitchGear 3'UTR luciferase reporter plasmidIL19 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL19
Clone
Products:
     
OriGene clones in human, mouse for IL19 (see all 9)
OriGene ORF clones in mouse, rat for IL19
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): IL19 (NM_153758)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL19
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL19
Sirion Biotech Customized lentivirus for stable overexpression of IL19 
                     Customized lentivirus expression plasmids for stable overexpression of IL19 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL19
OriGene qSTAR qPCR primer pairs in human, mouse for IL19
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL19
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL19
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL19

Additional mRNA sequence: 

AF192498.1 AF453946.1 AY040367.1 FJ380053.1 

2 DOTS entries:

DT.207952  DT.95299344 

13 AceView cDNA sequences:

NM_153758 AY040367 NM_013371 AI266722 CA306526 AF192498 CD366952 AF453946 
CA309757 AA151652 BX096099 AA151656 AA151733 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCTGTGATGT
IL19 Expression
About this image


See IL19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL19

SOURCE GeneReport for Unigene cluster: Hs.661017
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL19: 
          Oxidative Stress in human mouse rat
          Common Cytokines in human mouse rat
          Apoptosis 384HT in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for IL19
OriGene qSTAR qPCR primer pairs in human, mouse for IL19
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL19
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL19
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL19
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL19

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL19 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il191 , 5 interleukin 191, 5 78.43(n)1
70(a)1
  1 (56.89 cM)5
3292441  NM_001009940.11  NP_001009940.11 
 1309326565 
chicken
(Gallus gallus)
Aves IL196
interleukin 19
41(a)
1 ↔ 1
26(2517673-2519712)
zebrafish
(Danio rerio)
Actinopterygii il346
interleukin 34
25(a)
1 → many
11(21929589-21932934)


ENSEMBL Gene Tree for IL19 (if available)
TreeFam Gene Tree for IL19 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IL19 gene
IL202  IL242  
1 SIMAP similar gene for IL19 using alignment to 2 protein entries:     IL19_HUMAN (see all proteins):
IL20

IL19 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/939 SNPs in IL19 are shown (see all 939)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1867932651,2
--206970279(+) GTCCAG/TCCCAG 1 -- us2k10--------
rs1430345261,2
C--206970340(+) GAAAAC/GCGGAT 1 -- us2k10--------
rs1895944031,2
--206970406(+) CCTGAC/TTCCTT 1 -- us2k10--------
rs727569481,2
C,F--206970443(+) GGCTCA/GCTCCC 1 -- us2k15Minor allele frequency- G:0.18NA CSA WA 244
rs48451401,2
C,F,A,H--206970470(+) TGCTGC/TGGGAC 1 -- us2k120Minor allele frequency- T:0.05NS EA NA CSA WA 2124
rs1474510861,2
C--206970546(+) CAATCA/GTTGCC 1 -- us2k10--------
rs112805881,2
C--206970628(+) TGGTGTAGAA   
   TTC
/-
TAGAA
1 -- us2k11Minor allele frequency- -:0.50CSA 2
rs340382971,2
C--206970629(+) ATTCT-/AGAATTC
T
/TAGAATTC
CAGGC
1 -- us2k11NA 2
rs1811881841,2
C--206970781(+) ACCTCC/TGAGAG 1 -- us2k10--------
rs1853817591,2
--206970785(+) CCGAGA/GGTTCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IL19 (206972215 - 207016326 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for IL19:    About this table     
Variant IDTypeSubtypePubMed ID
esv997006CNV Deletion20482838
esv1601718CNV Insertion17803354


Human Gene Mutation Database (HGMD): IL19
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL19
DNA2.0 Custom Variant and Variant Library Synthesis for IL19

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605687    OMIM disorders: --

20/22 diseases for IL19 (see all 22):    About MalaCards
melanoma    major depressive disorder    venous thromboembolism    psoriasis
panic disorder    thromboembolism    vitiligo    uveitis
bronchiolitis    skin disease    crohn's disease    ulcerative colitis
multiple myeloma    asthma    inflammatory bowel disease    periodontitis
myeloma    type 1 diabetes    hepatitis b    hepatitis


IL19 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

7 Novoseek inferred disease relationships for IL19 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
psoriasis 70 21 16120148 (4), 16225599 (3), 15496954 (3), 17263806 (1) (see all 9)
inflammation 38.4 4 17263806 (1), 19834971 (1), 18021895 (1), 20001767 (1)
melanoma 24.5 6 12370360 (1), 15557163 (1), 11564763 (1), 11929132 (1)
hyperplasia 17.9 2 18397956 (1), 18669613 (1)
asthma 0 10 15557163 (3), 18539194 (2)
necrosis 0 2 18021895 (1), 17449492 (1)
tumors 0 8 18809337 (2), 16731153 (1), 12351624 (1), 18021895 (1)

Genetic Association Database (GAD): IL19
Human Genome Epidemiology (HuGE) Navigator: IL19 (24 documents)

Export disorders for IL19 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL19 gene, integrated from 9 sources (see all 105):
(articles sorted by number of sources associating them with IL19)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homolog of human interleukin-10 (IL-10). (PubMed id 11196675)1, 2, 3, 9 Gallagher G....Kotenko S.V. (2000)
  2. IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha. (PubMed id 12370360)1, 2, 9 Liao Y.-C.... Chang M.-S. (2002)
  3. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PubMed id 17263806)1, 4, 9 Kingo K....Silm H. (2007)
  4. Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. (PubMed id 12403790)1, 2, 9 Chang C.... Zdanov A. (2003)
  5. Association of interleukin-19 gene polymorphisms with age. (PubMed id 17522354)1, 4, 9 Okayama N....Hinoda Y. (2007)
  6. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PubMed id 19087313)1, 4, 9 Traks T....KA/ks S. (2008)
  7. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PubMed id 15815689)1, 4, 9 Oleksyk T.K....Smith M.W. (2005)
  8. Single nucleotide polymorphisms in inflammation-relat ed genes are associated with venous thromboembolism. (PubMed id 20603037)1, 4 Beckers M.M....Biesma D.H. (2010)
  9. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29949 HGNC: 5990 AceView: IL19 Ensembl:ENSG00000142224 euGenes: HUgn29949
ECgene: IL19 Kegg: 29949 H-InvDB: IL19

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL19 Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/il19/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL19 gene:
Search GeneIP for patents involving IL19

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