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Aliases for IL19 Gene

Aliases for IL19 Gene

  • Interleukin 19 2 3
  • Melanoma Differentiation Associated Protein-Like Protein 2 3
  • Melanoma Differentiation-Associated Protein-Like Protein 3 4
  • ZMDA1 3 4
  • NG.1 3 4
  • Interleukin-19 3
  • IL-10C 3
  • IL-19 4
  • MDA1 3

External Ids for IL19 Gene

Previous GeneCards Identifiers for IL19 Gene

  • GC01P205632
  • GC01P202682
  • GC01P203615
  • GC01P204055
  • GC01P203360
  • GC01P205038
  • GC01P206972
  • GC01P177670

Summaries for IL19 Gene

Entrez Gene Summary for IL19 Gene

  • The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL19 Gene

IL19 (Interleukin 19) is a Protein Coding gene. Diseases associated with IL19 include richter's syndrome and melanoma. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL24.

UniProtKB/Swiss-Prot for IL19 Gene

  • May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL19 Gene

Genomics for IL19 Gene

Regulatory Elements for IL19 Gene

Genomic Location for IL19 Gene

Start:
206,798,870 bp from pter
End:
206,842,981 bp from pter
Size:
44,112 bases
Orientation:
Plus strand

Genomic View for IL19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL19 Gene

Proteins for IL19 Gene

  • Protein details for IL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHD0-IL19_HUMAN
    Recommended name:
    Interleukin-19
    Protein Accession:
    Q9UHD0
    Secondary Accessions:
    • B6VEV9
    • Q5VUT3
    • Q96QR4
    • Q9NUA0

    Protein attributes for IL19 Gene

    Size:
    177 amino acids
    Molecular mass:
    20452 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL19 Gene

    Alternative splice isoforms for IL19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL19 Gene

Proteomics data for IL19 Gene at MOPED

Post-translational modifications for IL19 Gene

  • Glycosylation at Asn56 and Asn135

Other Protein References for IL19 Gene

No data available for DME Specific Peptides for IL19 Gene

Domains for IL19 Gene

Gene Families for IL19 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Suggested Antigen Peptide Sequences for IL19 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHD0

UniProtKB/Swiss-Prot:

IL19_HUMAN :
  • Q9UHD0
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL19: view

Function for IL19 Gene

Molecular function for IL19 Gene

UniProtKB/Swiss-Prot Function: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

Gene Ontology (GO) - Molecular Function for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 11196675
genes like me logo Genes that share ontologies with IL19: view

Phenotypes for IL19 Gene

MGI mutant phenotypes for IL19:
inferred from 1 alleles
GenomeRNAi human phenotypes for IL19:
genes like me logo Genes that share phenotypes with IL19: view

Animal Models for IL19 Gene

MGI Knock Outs for IL19:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL19 Gene

Localization for IL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL19 Gene COMPARTMENTS Subcellular localization image for IL19 gene
Compartment Confidence
extracellular 5
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11196675
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL19: view

Pathways for IL19 Gene

genes like me logo Genes that share pathways with IL19: view

Pathways by source for IL19 Gene

Gene Ontology (GO) - Biological Process for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response NAS 11196675
GO:0007165 signal transduction NAS 11196675
GO:0042226 interleukin-6 biosynthetic process IEA --
genes like me logo Genes that share ontologies with IL19: view

Compounds for IL19 Gene

(3) Novoseek inferred chemical compound relationships for IL19 Gene

Compound -log(P) Hits PubMed IDs
il 10 77.1 4
calcipotriol 51.4 4
cyclosporin a 0 3
genes like me logo Genes that share compounds with IL19: view

Transcripts for IL19 Gene

mRNA/cDNA for IL19 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL19 Gene

Interleukin 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL19 Gene

No ASD Table

Relevant External Links for IL19 Gene

GeneLoc Exon Structure for
IL19
ECgene alternative splicing isoforms for
IL19

Expression for IL19 Gene

mRNA expression in normal human tissues for IL19 Gene

mRNA differential expression in normal tissues according to GTEx for IL19 Gene

This gene is overexpressed in Esophagus - Mucosa (13.8), Minor Salivary Gland (13.2), and Stomach (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL19 Gene

SOURCE GeneReport for Unigene cluster for IL19 Gene Hs.661017

genes like me logo Genes that share expressions with IL19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IL19 Gene

Orthologs for IL19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL19 35
  • 97.98 (n)
  • 96.28 (a)
IL19 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL19 35
  • 83.43 (n)
  • 77.14 (a)
IL19 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL19 35
  • 84.88 (n)
  • 76.74 (a)
IL19 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il19 35
  • 78.43 (n)
  • 70 (a)
Il19 16
Il19 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL19 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL19 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il19 35
  • 77.91 (n)
  • 69.77 (a)
chicken
(Gallus gallus)
Aves IL19 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il19l 36
  • 24 (a)
OneToMany
Species with no ortholog for IL19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL19 Gene

ENSEMBL:
Gene Tree for IL19 (if available)
TreeFam:
Gene Tree for IL19 (if available)

Paralogs for IL19 Gene

Paralogs for IL19 Gene

Selected SIMAP similar genes for IL19 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL19: view

Variants for IL19 Gene

Sequence variations from dbSNP and Humsavar for IL19 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1798 -- 206,842,780(+) AATAG(C/G)CAAAA utr-variant-3-prime
rs908703 -- 206,826,618(+) GTGAA(C/G)CCCTC intron-variant
rs908704 -- 206,826,715(+) CATCC(A/G)ATTTC intron-variant
rs932186 -- 206,842,165(-) TCCCA(A/G)AACAT intron-variant
rs960326 -- 206,841,431(-) GTGAC(A/G)GCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL19 Gene

Variant ID Type Subtype PubMed ID
esv1601718 CNV Insertion 17803354
esv997006 CNV Deletion 20482838

Relevant External Links for IL19 Gene

HapMap Linkage Disequilibrium report
IL19
Human Gene Mutation Database (HGMD)
IL19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL19 Gene

Disorders for IL19 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IL19 Gene including...

Search for IL19 Gene in MalaCards »

(7) Novoseek inferred disease relationships for IL19 Gene

Disease -log(P) Hits PubMed IDs
psoriasis 70 16
inflammation 38.4 4
melanoma 24.5 4
hyperplasia 17.9 2
asthma 0 5

Relevant External Links for IL19

Genetic Association Database (GAD)
IL19
Human Genome Epidemiology (HuGE) Navigator
IL19
genes like me logo Genes that share disorders with IL19: view

No data available for UniProtKB/Swiss-Prot for IL19 Gene

Publications for IL19 Gene

  1. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homolog of human interleukin-10 (IL-10). (PMID: 11196675) Gallagher G. … Kotenko S.V. (Genes Immun. 2000) 2 3 4 23
  2. IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha. (PMID: 12370360) Liao Y.-C. … Chang M.-S. (J. Immunol. 2002) 3 4 23
  3. Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. (PMID: 12403790) Chang C. … Zdanov A. (J. Biol. Chem. 2003) 3 4 23
  4. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PMID: 15815689) Oleksyk T.K. … Smith M.W. (Genes Immun. 2005) 3 23 48
  5. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K. … Silm H. (Br. J. Dermatol. 2007) 3 23 48

Products for IL19 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IL19
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IL19
    • Block miRNA regulation of IL19 using miScript Target Protectors

    Sources for IL19 Gene

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