Aliases for IL18RAP Gene
External Ids for IL18RAP Gene
Previous GeneCards Identifiers for IL18RAP Gene
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
GeneCards Summary for IL18RAP Gene
IL18RAP (Interleukin 18 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL18RAP include celiac disease and leprosy. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is IL1RAP.
UniProtKB/Swiss-Prot for IL18RAP Gene
Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.