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IL18RAP Gene

protein-coding   GIFtS: 61
GCID: GC02P103035

Interleukin 18 Receptor Accessory Protein

  See IL18RAP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 18 Receptor Accessory Protein1 2     ACPL2 5
Interleukin-1 Receptor 72 3     CD218b2
Interleukin-18 Receptor Beta2 3     IL18RB2
CDw218b2 3     Cluster Of Differentiation W218b2
IL-18R-beta2 3     IL-18 Receptor Beta2
IL-18RAcP2 3     Interleukin-18 Receptor Accessory Protein2
IL-18Rbeta2 3     AcPL3
IL-1R-72 3     IL1R73
IL-1R72 3     Accessory Protein-Like3
IL-1RAcPL2 3     CD218b Antigen3
CD218 Antigen-Like Family Member B2 3     IL-1R Accessory Protein-Like3
IL-18 Receptor Accessory Protein2 3     Interleukin-18 Receptor Accessory Protein-Like3

External Ids:    HGNC: 59891   Entrez Gene: 88072   Ensembl: ENSG000001156077   OMIM: 6045095   UniProtKB: O952563   

Export aliases for IL18RAP gene to outside databases

Previous GC identifers: GC02P100899 GC02P101487 GC02P102639 GC02P102656 GC02P102493 GC02P102401 GC02P096799


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL18RAP Gene:
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18),
a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding
activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with
Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively
spliced transcript variants of this gene have been described, but their full-length nature is not known.
(provided by RefSeq, Feb 2014)

GeneCards Summary for IL18RAP Gene:
IL18RAP (interleukin 18 receptor accessory protein) is a protein-coding gene. Diseases associated with IL18RAP include leprosy, and celiac disease. GO annotations related to this gene include receptor activity. An important paralog of this gene is IL1RL2.

UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256
Function: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By
similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK

Gene Wiki entry for IL18RAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL18RAP gene promoter:
         NF-1/L   NF-1   ISGF-3   AML1a   RelA   Evi-1   GATA-1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL18RAP promoter sequence
   Search Chromatin IP Primers for IL18RAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL18RAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12.1

IL18RAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL18RAP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P103035:  view genomic region     (about GC identifiers)

Start:
103,035,149 bp from pter      End:
103,069,025 bp from pter
Size:
33,877 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256 (See protein sequence)
Recommended Name: Interleukin-18 receptor accessory protein precursor  
Size: 599 amino acids; 68310 Da
Subunit: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with
IL-18
Secondary accessions: B2RPJ3 Q3KPE7 Q53TT4 Q53TU5

Explore the universe of human proteins at neXtProt for IL18RAP: NX_O95256

Explore proteomics data for IL18RAP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn21, Asn119, Asn152, Asn345
  • Modification sites at PhosphoSitePlus

  • See IL18RAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003844.1  
    ENSEMBL proteins: 
     ENSP00000264260   ENSP00000389815   ENSP00000387201  

    IL18RAP Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: IL-18 receptor accessory protein


    5 InterPro protein domains:
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold
     IPR015621 IL-1_rcpt_fam
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O95256

    ProtoNet protein and cluster: O95256

    1 Blocks protein domain: IPB004075 Interleukin-1 receptor type I family signature

    UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    Find genes that share domains with IL18RAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I18RA_HUMAN, O95256
    Function: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By
    similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK
    Induction: Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9792649
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IL18RAP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL18RAP:
     Decreased Salmonella enterica  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il18rap):
     hematopoietic system  immune system 

    Find genes that share phenotypes with IL18RAP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il18raptm1Yeh for IL18RAP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL18RAP
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    2 qRT-PCR Assays for microRNAs that regulate IL18RAP:
    hsa-miR-140-3p hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL18RAP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I18RA_HUMAN, O95256: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL18RAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL18RAP About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Th1 Differentiation
    Th1 Differentiation0.38
    4Immune response IL 23 signaling pathway
    IL23-mediated signaling events0.38
    5Leishmaniasis
    Inflammatory bowel disease (IBD)0.34


    Find genes that share SuperPaths with IL18RAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL18RAP
        IL-1 Family Signaling Pathways
    Th1 Differentiation


    3 BioSystems Pathways for IL18RAP
        IL12-mediated signaling events
    IL12 signaling mediated by STAT4
    IL23-mediated signaling events



    2 Kegg Pathways  (Kegg details for IL18RAP):
        Cytokine-cytokine receptor interaction
    Inflammatory bowel disease (IBD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL18RAP: 
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL18RAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for IL18RAP (O952563 ENSP000002642604) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL18Q141163, ENSP000002803574I2D: score=1 STRING: ENSP00000280357
    CD48P093263, ENSP000003570254I2D: score=1 STRING: ENSP00000357025
    RAC1P630003I2D: score=1 
    CCR5ENSP000002923034STRING: ENSP00000292303
    GADD45BENSP000002156314STRING: ENSP00000215631
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS9792649
    GO:0006955immune response TAS9792649
    GO:0007165signal transduction ----
    GO:0007166cell surface receptor signaling pathway TAS9792649

    Find genes that share ontologies with IL18RAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL18RAP (I18RA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL18RAP gene: 
    NM_003853.3  

    Unigene Cluster for IL18RAP:

    Interleukin 18 receptor accessory protein
    Hs.158315  [show with all ESTs]
    Unigene Representative Sequence: AF077346
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264260(uc002tbx.3 uc010fiz.3) ENST00000450855 ENST00000409369
    ENST00000497795
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate IL18RAP:
    hsa-miR-140-3p hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL18RAP 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat IL18RAP
      QuantiFast Probe-based Assays in human, mouse, rat IL18RAP

    Additional mRNA sequence: 

    AF077346.1 AK300026.1 BC069630.1 BC106764.2 BC106765.2 BC137474.1 BC137475.1 DQ116957.1 

    2 DOTS entries:

    DT.70104766  DT.121020786 

    10 AceView cDNA sequences:

    NM_003853 BC069630 CB161543 AF077346 AW192167 BX108418 AW467474 AI735624 
    AI307682 CA432978 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL18RAP    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:        -                                         -     -           -     -     -                                       
    SP2:                                -     -           -     -           -     -     -                                       
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for IL18RAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL18RAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGTACAT
    IL18RAP Expression
    About this image


    IL18RAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
    IL18RAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL18RAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158315

    UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256
    Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in
    colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically
    coexpressed with IL18R1 in Th1 cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL18RAP: 
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IL18RAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18RAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL18RAP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il18rap1 , 5 interleukin 18 receptor accessory protein1, 5 76.49(n)1
    67.24(a)1
      1 (19.37 cM)5
    161741  NM_010553.31  NP_034683.11 
     405153625 
    chicken
    (Gallus gallus)
    Aves IL18RAP1 interleukin 18 receptor accessory protein 56.64(n)
    45.02(a)
      101750396  XM_004938507.1  XP_004938564.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL18RAP6
    interleukin 18 receptor accessory protein
    38(a)
    1 ↔ 1
    GL343243.1(1550668-1573314)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ400341.12   -- 78.9(n)    BQ400341.1 


    ENSEMBL Gene Tree for IL18RAP (if available)
    TreeFam Gene Tree for IL18RAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for IL18RAP gene
    IL1RL22  IL1RAPL22  IL1RAPL12  IL1RAP2  IL18R12  IL1R22  IL1RL12  IL1R12  

    Find genes that share paralogs with IL18RAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL18RAP (see all 873)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450632221,2
    C--96812622(+) TTCTC-/TATTATTA 1 -- int10--------
    rs1119598591,2
    C--96816670(+) CTTCA-/TTTTTT 1 -- int11Minor allele frequency- T:0.00CSA 2
    rs1388943811,2
    C--96817631(+) ATATA-/TGTGTGT 1 -- int10--------
    rs1143397881,2
    --96826647(+) TATTAA/TAAAAA 1 -- int10--------
    rs1150309531,2
    --102688827(+) CCTGGC/TGTCTG 1 -- us2k10--------
    rs1467298201,2
    --102688831(+) GTGTCC/TGGCTC 1 -- us2k10--------
    rs114656631,2
    C,F--102688938(+) ATAAAG/TCCAGG 1 -- us2k1 tfbs33Minor allele frequency- T:0.02NA EU 94
    rs800391191,2
    C,F--102689312(+) CCACAC/TGATAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs37552731,2
    C--102689346(-) tgcaaC/Gacact 1 -- us2k10--------
    rs1510589811,2
    --102689369(+) TCACAC/TCTGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL18RAP (103035149 - 103069025 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL18RAP: --
    Human Gene Mutation Database (HGMD): IL18RAP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL18RAP
    DNA2.0 Custom Variant and Variant Library Synthesis for IL18RAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604509    OMIM disorders: --

    3 diseases for IL18RAP:    
    About MalaCards
    leprosy    celiac disease    inflammatory bowel disease

    1 disease from the University of Copenhagen DISEASES database for IL18RAP:
    Celiac disease

    Find genes that share disorders with IL18RAP           About GenesLikeMe

    Genetic Association Database (GAD): IL18RAP
    Human Genome Epidemiology (HuGE) Navigator: IL18RAP (23 documents)

    Export disorders for IL18RAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL18RAP gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with IL18RAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel receptor subunit, AcPL, required for interleukin- 18 signaling. (PubMed id 9792649)1, 2, 3, 9 Born T.L.... Sims J.E. (J. Biol. Chem. 1998)
    2. Association study of the IL18RAP locus in three European populations with coeliac disease. (PubMed id 19103669)1, 4, 9 Koskinen L.L....Saavalainen P. (Hum. Mol. Genet. 2009)
    3. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PubMed id 19473509)1, 4, 9 Grisoni M.L....Tregouet D.A. (BMC Med. Genet. 2009)
    4. IL-18 receptors, their role in ligand binding and function: anti-IL- 1RAcPL antibody, a potent antagonist of IL-18. (PubMed id 11046021)1, 2, 9 Debets R.... Kastelein R.A. (J. Immunol. 2000)
    5. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. (PubMed id 10925275)1, 2, 9 Sareneva T.... Matikainen S. (J. Immunol. 2000)
    6. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. (PubMed id 18774397)1, 4, 9 Reijmerink N.E....Koppelman G.H. (J. Allergy Clin. Immunol. 2008)
    7. Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PubMed id 16043644)1, 4, 9 Tiret L....Blankenberg S. (Circulation 2005)
    8. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    9. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)1, 4 Wang K....Hakonarson H. (Hum. Mol. Genet. 2010)
    10. Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort. (PubMed id 19693089)1, 4 Amundsen S.S....Sollid L.M. (Genes Immun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8807 HGNC: 5989 AceView: IL18RAP Ensembl:ENSG00000115607 euGenes: HUgn8807
    ECgene: IL18RAP Kegg: 8807 H-InvDB: IL18RAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL18RAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IL18RAP gene:
    Search GeneIP for patents involving IL18RAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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