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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL18RAP Gene

protein-coding   GIFtS: 59
GCID: GC02P103035

interleukin 18 receptor accessory protein
 Explore 17 diseases affiliated with
IL18RAP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL18RAP    

Aliases
for IL18RAP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 18 Receptor Accessory Protein1 2     CD218 Antigen-Like Family Member B2 3
CD218b1 2     IL-18 Receptor Accessory Protein2 3
AcPL1 3     ACPL2 5
Interleukin-1 Receptor 72 3     IL18RB2
Interleukin-18 Receptor Beta2 3     IL-18 Receptor Beta2
CDw218b2 3     Interleukin-18 Receptor Accessory Protein2
IL-18R-Beta1     IL1R73
IL-18RAcP2 3     Accessory Protein-Like3
IL-18Rbeta2 3     CD218b Antigen3
IL-1R-72 3     IL-1R Accessory Protein-Like3
IL-1R72 3     Interleukin-18 Receptor Accessory Protein-Like3
IL-1RAcPL2 3     

External Ids:    HGNC: 59891   Entrez Gene: 88072   Ensembl: ENSG000001156077   OMIM: 6045095   UniProtKB: O952563   

Export aliases for IL18RAP gene to outside databases

Previous GC identifers: GC02P100899 GC02P101487 GC02P102639 GC02P102656 GC02P102493 GC02P102401 GC02P096799


Summaries
for IL18RAP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL18RAP:
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances
the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1
and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256
Function: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity).
Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK

Gene Wiki entry for IL18RAP


Genomic Views
for IL18RAP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL18RAP gene promoter:
         NF-1/L   NF-1   ISGF-3   AML1a   RelA   Evi-1   GATA-1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL18RAP promoter sequence
   Search SABiosciences Chromatin IP Primers for IL18RAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL18RAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12.1

IL18RAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL18RAP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P103035:  view genomic region     (about GC identifiers)

Start:
 103,035,149 bp from pter      End:
 103,069,025 bp from pter
Size:
 33,877 bases      Orientation:
 plus strand

Proteins
for IL18RAP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256 (See protein sequence)
Recommended Name: Interleukin-18 receptor accessory protein precursor  
Size: 599 amino acids; 68310 Da
Subunit: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with
IL-18
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B2RPJ3 Q3KPE7 Q53TT4 Q53TU5

Explore the universe of human proteins at neXtProt for IL18RAP: NX_O95256

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95256

    • IL18RAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003844.1  
    ENSEMBL proteins: 
     ENSP00000264260   ENSP00000389815   ENSP00000387201  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for IL18RAP (IL-18 R beta/IL-1 R7)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: IL18RAP
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    Novus Biologicals IL18RAP Proteins
    Novus Biologicals IL18RAP Lysates
    Sino Biological Recombinant Protein for IL18RAP
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IL18RAP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0016021integral to membrane IEA--


    IL18RAP for ontologies           About GeneDecksing



    IL18RAP Antibody Products: 
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    ThermoFisher Antibodies for IL18RAP

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    Uscn ELISAs and CLIAs for IL18RAP

    Protein Domains /
    Families
    for IL18RAP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL18RAP for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015621 IL1-receptor_fam
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O95256

    ProtoNet protein and cluster: O95256

    1 Blocks protein family: IPB004075 Interleukin-1 receptor type I family signature

    UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 TIR domain


    Function
    for IL18RAP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256
    Function: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity).
    Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK
    Induction: Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL18RAP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL18RAP:
    hsa-miR-140-3p hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IL18RAP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL18RAP (see all 7)
    OriGene shRNA RFP: IL18RAP
    OriGene siRNA: IL18RAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL18RAP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IL18RAP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL18RAP (see all 2)
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    Sino Biological Human cDNA Clone for IL18RAP
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL18RAP 

    Cell Line
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    Search LifeMap BioReagents cell lines for IL18RAP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18RAP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9792649
    GO:0004888transmembrane signaling receptor activity IEA--


    IL18RAP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IL18RAP:
     Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-out Il18raptm1Yeh for IL18RAP
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Il18rap):
     immune system 

    IL18RAP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IL18RAP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IL12 signaling mediated by STAT4
    		IL12 signaling mediated by STAT41.00
    2IL27-mediated signaling events
    		Th1 Differentiation0.38
    3Immune response IL-12-induced IFN-gamma production
    		IL12-mediated signaling events0.33
    4PEDF Induced Signaling
    		Cytokine-cytokine receptor interaction0.26
    5Development_PDGF signaling via STATs and NF-kB
    		IL23-mediated signaling events0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for IL18RAP
        Th1 Differentiation


    3 BioSystems Pathways for IL18RAP 
        IL12 signaling mediated by STAT4
    IL12-mediated signaling events
    IL23-mediated signaling events


    1         Kegg Pathway  (Kegg details for IL18RAP):
        Cytokine-cytokine receptor interaction


    IL18RAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL18RAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for IL18RAP (O952563 ENSP000002642604) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL18Q141163, ENSP000002803574I2D: score=1 STRING: ENSP00000280357
    CD48P093263, ENSP000003570254I2D: score=1 STRING: ENSP00000357025
    RAC1P630003I2D: score=1 
    CCR5ENSP000002923034STRING: ENSP00000292303
    GADD45BENSP000002156314STRING: ENSP00000215631
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS9792649
    GO:0006955immune response TAS9792649
    GO:0007166cell surface receptor signaling pathway TAS9792649
    GO:0045087innate immune response IEA--


    IL18RAP for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL18RAP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL18RAP
    Search CenterWatch for drugs/clinical trials and news about IL18RAP / I18RA 

    Transcripts
    for IL18RAP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL18RAP gene: 
    NM_003853.2  

    Unigene Cluster for IL18RAP:

    Interleukin 18 receptor accessory protein
    Hs.158315  [show with all ESTs]
    Unigene Representative Sequence: AF077346
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264260(uc002tbx.3 uc010fiz.3) ENST00000450855 ENST00000409369
    ENST00000497795

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IL18RAP
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL18RAP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IL18RAP:
    hsa-miR-140-3p hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IL18RAP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL18RAP (see all 7)
    OriGene shRNA RFP: IL18RAP
    OriGene siRNA: IL18RAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL18RAP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL18RAP (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL18RAP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IL18RAP (NM_003853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL18RAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL18RAP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL18RAP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL18RAP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL18RAP

    Additional cDNA sequence: 

    AF077346.1 AK300026.1 BC069630.1 BC106764.2 BC106765.2 BC137474.1 BC137475.1 DQ116957.1 

    2 DOTS entries:

    DT.70104766  DT.121020786 

    10 AceView cDNA sequences:

    NM_003853 BC069630 AW192167 BX108418 AW467474 CB161543 AF077346 AI735624 
    AI307682 CA432978 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL18RAP    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:        -                                         -     -           -     -     -                                       
    SP2:                                -     -           -     -           -     -     -                                       
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for IL18RAP

    Expression
    for IL18RAP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL18RAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTGTACAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL18RAP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL18RAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL18RAP

    SOURCE GeneReport for Unigene cluster: Hs.158315

    UniProtKB/Swiss-Prot: I18RA_HUMAN, O95256
    Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon,
    but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with
    IL18R1 in Th1 cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL18RAP: 
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL18RAP
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18RAP

    Orthologs
    for IL18RAP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL18RAP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IL18RAP6
    		 Uncharacterized protein
    		 42(a)
    		 1 ↔ 1
    		 1(138147956-138161221)
    lizard
    (Anolis carolinensis)    		 Reptilia IL18RAP6
    		 --
    		 39(a)
    		 1 ↔ 1
    		 GL343243.1(1552719-1573267)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BQ400341.12   -- 78.9(n)    BQ400341.1 


    ENSEMBL Gene Tree for IL18RAP (if available)
    TreeFam Gene Tree for IL18RAP (if available) 

    Paralogs
    for IL18RAP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL18RAP gene
    IL1RAPL22  IL1RL22  IL1RAP2  IL1RAPL12  IL18R12  SIGIRR2  IL1R22  IL1RL12  
    IL1R12  

    IL18RAP for paralogs           About GeneDecksing



    Genomic Variants
    for IL18RAP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/749 NCBI SNPs in IL18RAP are shown (see all 749)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs114656631,2
    		C,F,--96797745(+) ATAAAG/TCCAGG 1 -- us2k1 tfbs33Minor allele frequency- T:0.02NA EU 94
    rs800391191,2
    		--96798119(+) CCACAC/TGATAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs37552731,2
    		C,--96798153(-) tgcaaC/Gacact 1 -- us2k10--------
    rs114656651,2
    		C,--96798192(+) CATGTG/AATGTG 1 -- us2k14Minor allele frequency- A:0.01NA EU WA 212
    rs747903601,2
    		C,--96798637(+) TGTTTC/TACTGC 1 -- us2k10--------
    rs114656691,2
    		C,F,H,--96798658(+) CACTGT/CTGGAA 1 -- us2k17Minor allele frequency- C:0.01NA EU NS EA 510
    rs101778151,2
    		C,F,A,H,--96798681(+) AAACCC/TTCACA 1 -- us2k120Minor allele frequency- T:0.08NA EU NS EA WA 1740
    rs114656711,2
    		C,F,H,--96798948(+) GGAGGA/GTGTTA 1 -- us2k17Minor allele frequency- G:0.00NA EU NS EA 506
    rs48515811,2
    		C,F,H,--96799115(+) TAAAAA/GCTCAA 1 -- us2k114Minor allele frequency- G:0.06NA EU NS EA 1194
    rs114656721,2
    		F,H--96799294(+) AGAAAA/TCCAAA 1 -- us2k1 trp37Minor allele frequency- T:0.01NA EU NS EA 482

    HapMap Linkage Disequilibrium report for IL18RAP (103035149 - 103069025 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL18RAP: --
    Human Gene Mutation Database (HGMD): IL18RAP

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    Disorders / Diseases
    for IL18RAP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL18RAP for disorders           About GeneDecksing

    OMIM gene information: 604509    OMIM disorders: --

    17 diseases for IL18RAP:    About MalaCards
    graft versus host disease    ankylosing spondylitis    coronary heart disease    ulcerative colitis
    spondylitis    celiac disease    rheumatoid arthritis    atopy
    crohn's disease    hepatitis b    arthritis    osteoarthritis
    asthma    hepatitis    hypoxia    schizophrenia
    acute graft versus host disease

    Genetic Association Database (GAD): IL18RAP
    Human Genome Epidemiology (HuGE) Navigator: IL18RAP (23 documents)

    Export disorders for IL18RAP gene to outside databases

    Publications
    for IL18RAP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL18RAP gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with IL18RAP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel receptor subunit, AcPL, required for interleukin- 18 signaling. (PubMed id 9792649)1, 2, 3, 9 Born T.L.... Sims J.E. (1998)
    2. IL-18 receptors, their role in ligand binding and function: anti-IL- 1RAcPL antibody, a potent antagonist of IL-18. (PubMed id 11046021)1, 2, 9 Debets R.... Kastelein R.A. (2000)
    3. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. (PubMed id 10925275)1, 2, 9 Sareneva T.... Matikainen S. (2000)
    4. Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PubMed id 16043644)1, 4, 9 Tiret L....Blankenberg S. (2005)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Association study of the IL18RAP locus in three European populations with coeliac disease. (PubMed id 19103669)1, 9 Koskinen L.L....Saavalainen P. (2009)
    8. Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues. (PubMed id 17897836)1, 9 Fiszer D....Kurpisz M. (2007)
    9. Lack of association between polymorphisms of the IL18 R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PubMed id 19473509)1, 9 Grisoni M.L....Tregouet D.A. (2009)
    10. Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile id iopathic arthritis. (PubMed id 19714583)1, 9 de Jager W....Prakken B.J. (2009)

    External Searches for IL18RAP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    Genome Databases showing IL18RAP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8807 HGNC: 5989 AceView: IL18RAP Ensembl:ENSG00000115607 euGenes: HUgn8807
    ECgene: IL18RAP Kegg: 8807 H-InvDB: IL18RAP

    Other Databases showing IL18RAP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL18RAP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL18RAP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IL18RAP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL18RAP gene:
    Search GeneIP for patents involving IL18RAP

    GeneCards and IP:
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