Aliases for IL18RAP Gene
External Ids for IL18RAP Gene
Previous GeneCards Identifiers for IL18RAP Gene
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
GeneCards Summary for IL18RAP Gene
IL18RAP (Interleukin 18 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL18RAP include Celiac Disease and Leprosy. Among its related pathways are Immune response IL-23 signaling pathway and Innate Immune System. GO annotations related to this gene include receptor activity. An important paralog of this gene is IL1RAPL2.
UniProtKB/Swiss-Prot for IL18RAP Gene
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.