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Aliases for IL18RAP Gene

Aliases for IL18RAP Gene

  • Interleukin 18 Receptor Accessory Protein 2 3 5
  • CD218 Antigen-Like Family Member B 3 4
  • IL-18 Receptor Accessory Protein 3 4
  • Interleukin-18 Receptor Beta 3 4
  • Interleukin-1 Receptor 7 3 4
  • IL-18R-Beta 3 4
  • IL-18Rbeta 3 4
  • IL-18RAcP 3 4
  • IL-1RAcPL 3 4
  • CDw218b 3 4
  • IL-1R-7 3 4
  • IL-1R7 3 4
  • ACPL 3 4
  • Interleukin-18 Receptor Accessory Protein-Like 4
  • Cluster Of Differentiation W218b 3
  • IL-1R Accessory Protein-Like 4
  • Accessory Protein-Like 4
  • IL-18 Receptor Beta 3
  • CD218b Antigen 4
  • CD218b 3
  • IL18RB 3
  • IL1R7 4

External Ids for IL18RAP Gene

Previous GeneCards Identifiers for IL18RAP Gene

  • GC02P100899
  • GC02P101487
  • GC02P102639
  • GC02P102656
  • GC02P102493
  • GC02P102401
  • GC02P103035
  • GC02P096799

Summaries for IL18RAP Gene

Entrez Gene Summary for IL18RAP Gene

  • The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

GeneCards Summary for IL18RAP Gene

IL18RAP (Interleukin 18 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL18RAP include Celiac Disease and Leprosy. Among its related pathways are Toll-Like receptor Signaling Pathways and Immune System. GO annotations related to this gene include receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL18RAP Gene

  • Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.

Gene Wiki entry for IL18RAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18RAP Gene

Genomics for IL18RAP Gene

Regulatory Elements for IL18RAP Gene

Enhancers for IL18RAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL18RAP on UCSC Golden Path with GeneCards custom track

Promoters for IL18RAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL18RAP on UCSC Golden Path with GeneCards custom track

Genomic Location for IL18RAP Gene

102,418,558 bp from pter
102,452,568 bp from pter
34,011 bases
Plus strand

Genomic View for IL18RAP Gene

Genes around IL18RAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18RAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18RAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18RAP Gene

Proteins for IL18RAP Gene

  • Protein details for IL18RAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-18 receptor accessory protein
    Protein Accession:
    Secondary Accessions:
    • B2RPJ3
    • Q3KPE7
    • Q3KPE8
    • Q53TT4
    • Q53TU5

    Protein attributes for IL18RAP Gene

    599 amino acids
    Molecular mass:
    68310 Da
    Quaternary structure:
    • Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18.

    Three dimensional structures from OCA and Proteopedia for IL18RAP Gene

    Alternative splice isoforms for IL18RAP Gene


neXtProt entry for IL18RAP Gene

Proteomics data for IL18RAP Gene at MOPED

Post-translational modifications for IL18RAP Gene

  • Glycosylation at Asn 21, Asn 119, Asn 152, and Asn 345
  • Modification sites at PhosphoSitePlus

Other Protein References for IL18RAP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL18RAP (IL-18 R beta/IL-1 R7)

No data available for DME Specific Peptides for IL18RAP Gene

Domains & Families for IL18RAP Gene

Protein Domains for IL18RAP Gene

Suggested Antigen Peptide Sequences for IL18RAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL18RAP: view

Function for IL18RAP Gene

Molecular function for IL18RAP Gene

UniProtKB/Swiss-Prot Function:
Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.
UniProtKB/Swiss-Prot Induction:
Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.
genes like me logo Genes that share phenotypes with IL18RAP: view

Animal Models for IL18RAP Gene

MGI Knock Outs for IL18RAP:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL18RAP

miRNA for IL18RAP Gene

miRTarBase miRNAs that target IL18RAP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18RAP Gene

Localization for IL18RAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18RAP Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL18RAP Gene COMPARTMENTS Subcellular localization image for IL18RAP gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IL18RAP Gene

Pathways & Interactions for IL18RAP Gene

genes like me logo Genes that share pathways with IL18RAP: view

Pathways by source for IL18RAP Gene

Gene Ontology (GO) - Biological Process for IL18RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9792649
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 9792649
genes like me logo Genes that share ontologies with IL18RAP: view

No data available for SIGNOR curated interactions for IL18RAP Gene

Drugs & Compounds for IL18RAP Gene

No Compound Related Data Available

Transcripts for IL18RAP Gene

mRNA/cDNA for IL18RAP Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL18RAP Gene

Interleukin 18 receptor accessory protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL18RAP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - - -

Relevant External Links for IL18RAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL18RAP Gene

mRNA expression in normal human tissues for IL18RAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18RAP Gene

This gene is overexpressed in Whole Blood (x43.5).

SOURCE GeneReport for Unigene cluster for IL18RAP Gene Hs.158315

mRNA Expression by UniProt/SwissProt for IL18RAP Gene

Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.
genes like me logo Genes that share expression patterns with IL18RAP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL18RAP Gene

Orthologs for IL18RAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18RAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL18RAP 35
  • 81.16 (n)
  • 73.24 (a)
IL18RAP 36
  • 72 (a)
(Canis familiaris)
Mammalia IL18RAP 35
  • 82.02 (n)
  • 74.37 (a)
IL18RAP 36
  • 74 (a)
(Mus musculus)
Mammalia Il18rap 35
  • 76.49 (n)
  • 67.24 (a)
Il18rap 16
Il18rap 36
  • 64 (a)
(Pan troglodytes)
Mammalia IL18RAP 35
  • 99 (n)
  • 98.16 (a)
IL18RAP 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Il18rap 35
  • 76.37 (n)
  • 68.11 (a)
(Monodelphis domestica)
Mammalia IL18RAP 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia IL18RAP 36
  • 48 (a)
(Gallus gallus)
Aves IL18RAP 35
  • 56.64 (n)
  • 45.02 (a)
IL18RAP 36
  • 42 (a)
(Anolis carolinensis)
Reptilia IL18RAP 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il18rap 35
  • 54.4 (n)
  • 46.38 (a)
Species with no ortholog for IL18RAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18RAP Gene

Gene Tree for IL18RAP (if available)
Gene Tree for IL18RAP (if available)

Paralogs for IL18RAP Gene

Paralogs for IL18RAP Gene

genes like me logo Genes that share paralogs with IL18RAP: view

Variants for IL18RAP Gene

Sequence variations from dbSNP and Humsavar for IL18RAP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11465716 - 102,445,316(+) AGTCC(A/G)TCCAA downstream-variant-500B, reference, missense
rs1558650 -- 102,443,564(-) GTACA(A/T)CTGTC intron-variant, utr-variant-3-prime
rs1558651 -- 102,443,153(-) GAGAA(C/T)ACTTT intron-variant
rs1558652 -- 102,441,868(-) CTCTG(C/T)CACCC intron-variant
rs1807782 -- 102,416,687(-) CACCC(A/G)GCTTC upstream-variant-2KB

Variation tolerance for IL18RAP Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL18RAP Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL18RAP Gene

Disorders for IL18RAP Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL18RAP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
celiac disease
  • celiac sprue
  • leprosy, susceptibility to
crohn's disease
  • ileitis
non-syndromic x-linked intellectual disability
  • mrx
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL18RAP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL18RAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18RAP Gene

Publications for IL18RAP Gene

  1. Cloning of a novel receptor subunit, AcPL, required for interleukin- 18 signaling. (PMID: 9792649) Born T.L. … Sims J.E. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Association study of the IL18RAP locus in three European populations with coeliac disease. (PMID: 19103669) Koskinen L.L. … Saavalainen P. (Hum. Mol. Genet. 2009) 3 23
  3. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PMID: 19473509) Grisoni M.L. … Tregouet D.A. (BMC Med. Genet. 2009) 3 23
  4. Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. (PMID: 19714583) de Jager W. … Prakken B.J. (Arthritis Rheum. 2009) 3 23
  5. Comprehensive evaluation of positional candidates in the IL-18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity. (PMID: 18092318) Shirts B.H. … Nimgaonkar V.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23

Products for IL18RAP Gene

Sources for IL18RAP Gene