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Aliases for IL18RAP Gene

Aliases for IL18RAP Gene

  • Interleukin 18 Receptor Accessory Protein 2 3
  • ACPL 3 4 6
  • CD218 Antigen-Like Family Member B 3 4
  • IL-18 Receptor Accessory Protein 3 4
  • Interleukin-18 Receptor Beta 3 4
  • Interleukin-1 Receptor 7 3 4
  • IL-18R-Beta 3 4
  • IL-18Rbeta 3 4
  • IL-18RAcP 3 4
  • IL-1RAcPL 3 4
  • CDw218b 3 4
  • IL-1R-7 3 4
  • IL-1R7 3 4
  • Interleukin-18 Receptor Accessory Protein-Like 4
  • Interleukin-18 Receptor Accessory Protein 3
  • Cluster Of Differentiation W218b 3
  • IL-1R Accessory Protein-Like 4
  • Accessory Protein-Like 4
  • IL-18 Receptor Beta 3
  • CD218b Antigen 4
  • CD218b 3
  • IL18RB 3
  • IL1R7 4

External Ids for IL18RAP Gene

Previous GeneCards Identifiers for IL18RAP Gene

  • GC02P100899
  • GC02P101487
  • GC02P102639
  • GC02P102656
  • GC02P102493
  • GC02P102401
  • GC02P103035
  • GC02P096799

Summaries for IL18RAP Gene

Entrez Gene Summary for IL18RAP Gene

  • The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

GeneCards Summary for IL18RAP Gene

IL18RAP (Interleukin 18 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL18RAP include leprosy and celiac disease. Among its related pathways are NOD-like Receptor Signaling Pathways and PEDF Induced Signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL18RAP Gene

  • Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.

Gene Wiki entry for IL18RAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18RAP Gene

Genomics for IL18RAP Gene

Regulatory Elements for IL18RAP Gene

Genomic Location for IL18RAP Gene

102,418,689 bp from pter
102,452,565 bp from pter
33,877 bases
Plus strand

Genomic View for IL18RAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL18RAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18RAP Gene

Proteins for IL18RAP Gene

  • Protein details for IL18RAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-18 receptor accessory protein
    Protein Accession:
    Secondary Accessions:
    • B2RPJ3
    • Q3KPE7
    • Q3KPE8
    • Q53TT4
    • Q53TU5

    Protein attributes for IL18RAP Gene

    599 amino acids
    Molecular mass:
    68310 Da
    Quaternary structure:
    • Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18.

    Three dimensional structures from OCA and Proteopedia for IL18RAP Gene

    Alternative splice isoforms for IL18RAP Gene


neXtProt entry for IL18RAP Gene

Proteomics data for IL18RAP Gene at MOPED

Post-translational modifications for IL18RAP Gene

  • Glycosylation at Asn21, Asn119, Asn152, and Asn345
  • Modification sites at PhosphoSitePlus

Other Protein References for IL18RAP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL18RAP (IL-18 R beta/IL-1 R7)

Protein Products

  • Cloud-Clone Corp. Proteins for IL18RAP

No data available for DME Specific Peptides for IL18RAP Gene

Domains for IL18RAP Gene

Gene Families for IL18RAP Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors

Protein Domains for IL18RAP Gene

Suggested Antigen Peptide Sequences for IL18RAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95256
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL18RAP: view

Function for IL18RAP Gene

Molecular function for IL18RAP Gene

UniProtKB/Swiss-Prot Function:
Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.
UniProtKB/Swiss-Prot Induction:
Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.

Gene Ontology (GO) - Molecular Function for IL18RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9792649
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IL18RAP: view

Phenotypes for IL18RAP Gene

genes like me logo Genes that share phenotypes with IL18RAP: view

Animal Models for IL18RAP Gene

MGI Knock Outs for IL18RAP:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18RAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL18RAP Gene

Localization for IL18RAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18RAP Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL18RAP Gene COMPARTMENTS Subcellular localization image for IL18RAP gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL18RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL18RAP: view

Pathways for IL18RAP Gene

genes like me logo Genes that share pathways with IL18RAP: view

Pathways by source for IL18RAP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • T Helper Cell Differentiation in human,mouse,rat

Gene Ontology (GO) - Biological Process for IL18RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9792649
GO:0006955 immune response TAS 9792649
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway TAS 9792649
genes like me logo Genes that share ontologies with IL18RAP: view

Transcripts for IL18RAP Gene

mRNA/cDNA for IL18RAP Gene

(10) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL18RAP Gene

Interleukin 18 receptor accessory protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18RAP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18RAP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - - -

Relevant External Links for IL18RAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL18RAP Gene

mRNA expression in normal human tissues for IL18RAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18RAP Gene

This gene is overexpressed in Whole Blood (43.5).

SOURCE GeneReport for Unigene cluster for IL18RAP Gene Hs.158315

mRNA Expression by UniProt/SwissProt for IL18RAP Gene

Tissue specificity: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.
genes like me logo Genes that share expressions with IL18RAP: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for IL18RAP Gene

Orthologs for IL18RAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18RAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL18RAP 35
  • 81.16 (n)
  • 73.24 (a)
IL18RAP 36
  • 72 (a)
(Canis familiaris)
Mammalia IL18RAP 35
  • 82.02 (n)
  • 74.37 (a)
IL18RAP 36
  • 74 (a)
(Mus musculus)
Mammalia Il18rap 35
  • 76.49 (n)
  • 67.24 (a)
Il18rap 16
Il18rap 36
  • 64 (a)
(Pan troglodytes)
Mammalia IL18RAP 35
  • 99 (n)
  • 98.16 (a)
IL18RAP 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Il18rap 35
  • 76.37 (n)
  • 68.11 (a)
(Monodelphis domestica)
Mammalia IL18RAP 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia IL18RAP 36
  • 48 (a)
(Gallus gallus)
Aves IL18RAP 35
  • 56.64 (n)
  • 45.02 (a)
IL18RAP 36
  • 42 (a)
(Anolis carolinensis)
Reptilia IL18RAP 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il18rap 35
  • 54.4 (n)
  • 46.38 (a)
Species with no ortholog for IL18RAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18RAP Gene

Gene Tree for IL18RAP (if available)
Gene Tree for IL18RAP (if available)

Paralogs for IL18RAP Gene

Paralogs for IL18RAP Gene

genes like me logo Genes that share paralogs with IL18RAP: view

Variants for IL18RAP Gene

Sequence variations from dbSNP and Humsavar for IL18RAP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs77556243 -- 102,439,365(+) GGAAA(C/T)GTTTA intron-variant
rs77233813 -- 102,434,402(+) GTTAA(-/ATG)ATAAT intron-variant
rs76931603 -- 102,435,842(+) GTCTT(C/T)ATTTT intron-variant
rs76695960 -- 102,446,337(+) TTTTT(G/T)GTTAC intron-variant
rs76655799 -- 102,426,428(+) TTGTT(A/T)AAATT intron-variant

Relevant External Links for IL18RAP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL18RAP Gene

Disorders for IL18RAP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IL18RAP Gene in MalaCards »

(3) Diseases for IL18RAP Gene including...

(1) University of Copenhagen DISEASES for IL18RAP Gene

Relevant External Links for IL18RAP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL18RAP: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for IL18RAP Gene

Publications for IL18RAP Gene

  1. Cloning of a novel receptor subunit, AcPL, required for interleukin- 18 signaling. (PMID: 9792649) Born T.L. … Sims J.E. (J. Biol. Chem. 1998) 2 3 4 23
  2. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. (PMID: 10925275) Sareneva T. … Matikainen S. (J. Immunol. 2000) 3 4 23
  3. IL-18 receptors, their role in ligand binding and function: anti-IL- 1RAcPL antibody, a potent antagonist of IL-18. (PMID: 11046021) Debets R. … Kastelein R.A. (J. Immunol. 2000) 3 4 23
  4. Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PMID: 16043644) Tiret L. … Blankenberg S. (Circulation 2005) 3 23 48
  5. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. (PMID: 18774397) Reijmerink N.E. … Koppelman G.H. (J. Allergy Clin. Immunol. 2008) 3 23 48

Products for IL18RAP Gene

Sources for IL18RAP Gene

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