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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL18R1 Gene

protein-coding GIFtS: 63
GCID: GC02P102928

interleukin 18 receptor 1

Explore 123 diseases affiliated with
IL18R1 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 18 Receptor 1¹ ²		IL1R-Rp¹
IL1RRP¹ ² ³ ⁵		CD218 Antigen-Like Family Member A² ³
IL-1Rrp¹ ² ³		IL1 Receptor-Related Protein² ³
CD218a¹ ²		IL18RA²
CDw218a² ³		Cytokine Receptor²
IL-18R-1² ³		Interleukin-18 Receptor 1²
IL-18R1² ³		CD218a Antigen³

External Ids:	HGNC: 5988¹	Entrez Gene: 8809²	Ensembl: ENSG00000115604⁷	OMIM: 604494⁵	UniProtKB: Q13478³

Export aliases for IL18R1 gene to outside databases

Previous GC identifers: GC02P100843 GC02P101431 GC02P102583 GC02P102600 GC02P102437 GC02P102345 GC02P096744

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL18R1:

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This

receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha

and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other

members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a

gene cluster on chromosome 2q. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL18R_HUMAN, Q13478

Function: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B

Gene Wiki entry for IL18R1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL18R1 gene promoter:
GR AML1a GR-beta AP-4 RORalpha2 FOXL1 Cart-1 GR-alpha ZID TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL18R1 promoter sequence

Search SABiosciences Chromatin IP Primers for IL18R1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL18R1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12 Ensembl cytogenetic band: 2q12.1 HGNC cytogenetic band: 2q12

IL18R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL18R1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P102928: view genomic region (about GC identifiers)

Start:	102,927,989 bp from pter	End:	103,015,218 bp from pter
Size:	87,230 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL18R_HUMAN, Q13478 (See protein sequence)

Recommended Name: Interleukin-18 receptor 1 precursor

Size: 541 amino acids; 62304 Da

Subunit: Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: B2R9Y5 Q52LC9

Explore the universe of human proteins at neXtProt for IL18R1: NX_Q13478

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13478

IL18R1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003846.1

ENSEMBL proteins:

ENSP00000386663 ENSP00000387211 ENSP00000233957 ENSP00000334030

Human Recombinant Protein Products:

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	Novus Biologicals IL18R1 Proteins Novus Biologicals IL18R1 Lysate
	Sino Biological Recombinant Protein for IL18R1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IL18R1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005886	plasma membrane	TAS	9325300
GO:0016021	integral to membrane	IEA	--

IL18R1 for ontologies About GeneDecksing

IL18R1 Antibody Products:

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	Novus Biologicals IL18R1 Antibodies
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	Uscn Antibodies for IL18R1
	ThermoFisher Antibodies for IL18R1

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL18R1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL18R1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR015621 IL1-receptor_fam

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR000157 TIR_dom

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q13478

ProtoNet protein and cluster: Q13478

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB004075 Interleukin-1 receptor type I family signature

UniProtKB/Swiss-Prot: IL18R_HUMAN, Q13478

Similarity: Belongs to the interleukin-1 receptor family

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 TIR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL18R_HUMAN, Q13478

Function: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B

Genatlas biochemistry entry for IL18R1:

interleukin 18 receptor 1,type 1

miRNA Products:		OriGene 3'-UTR Clone: IL18R1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL18R1
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IL18R1:
		hsa-miR-525-5p hsa-miR-3658 hsa-miR-377 hsa-miR-3915 hsa-miR-520a-5p hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: IL18R1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL18R1 (see all 7) OriGene shRNA RFP: IL18R1 OriGene siRNA: IL18R1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL18R1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL18R1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL18R1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL18R1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL18R1 (NM_003855)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL18R1
		Search LifeMap BioReagents cell lines for IL18R1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18R1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9325300
GO:0004908	interleukin-1 receptor activity	IEA	--

IL18R1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL18R1:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Il18r1^tm1Aki for IL18R1
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Il18r1):

immune system

IL18R1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

PEDF Induced Signaling

	STAT3 Pathway	0.47			Glucocorticoid Receptor Signaling	0.27
	PGC1Alpha Pathway	0.33			Cytokine-cytokine receptor interaction	0.26

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Immune response IL-12 signaling pathway

Immune response IL-12 signaling pathway

1.00

Immune response_IL-12 signaling pathway

0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IL18R1

	Immune response IL-12-induced IFN-gamma production
	Immune response IL-12 signaling pathway

1 R&D Systems Pathway for IL18R1

Th1 Differentiation

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL18R1 (see all 13)

	THC Differentiation Pathway
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Glucocorticoid Receptor Signaling

2 GeneGo (Thomson Reuters) Pathways for IL18R1

	Immune response IL-12 signaling pathway
	Immune response IL-12-induced IFN-gamma production

3 BioSystems Pathways for IL18R1

	IL12 signaling mediated by STAT4
	IL23-mediated signaling events
	IL12-mediated signaling events

1 Kegg Pathway (Kegg details for IL18R1):

Cytokine-cytokine receptor interaction

IL18R1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL18R1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/15 Interacting proteins for IL18R1 (Q13478³ ENSP00000233957⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL18	Q14116³, ENSP00000280357⁴	I2D: score=3 STRING: ENSP00000280357
IL1RAP	Q9NPH3³, ENSP00000072516⁴	I2D: score=3 STRING: ENSP00000072516
IL37	Q9NZH6³, ENSP00000263326⁴	I2D: score=3 STRING: ENSP00000263326
CD48	P09326³, ENSP00000357025⁴	I2D: score=2 STRING: ENSP00000357025
IRAK1	P51617³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	9325300
GO:0007165	signal transduction	TAS	9325300
GO:0045087	innate immune response	IEA	--

IL18R1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL18R1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL18R1
10/71 Novoseek chemical compound relationships for IL18R1 gene (see all 71) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	85.9	40	8514784 (1), 9501088 (1), 10899245 (1), 16774741 (1) (see all 37)
tyrosine	78.1	255	9269296 (3), 7871433 (3), 8294397 (2), 7525556 (2) (see all 99)
phosphotyrosine	53.4	8	9446647 (1), 16426581 (1), 8843168 (1), 9062191 (1) (see all 7)
neopterin	39.7	12	15508904 (3), 10924610 (2), 11256860 (1), 12696651 (1) (see all 8)
propanil	39.6	4	10383417 (1), 8780729 (1), 9133424 (1)
phosphatidylinositol	36.3	5	9305869 (1), 11509545 (1), 7630930 (1), 10605001 (1) (see all 5)
serine	28.6	7	8157958 (1), 8134361 (1), 15940250 (1), 16364194 (1) (see all 7)
rantes	22.8	3	10572378 (1), 10508185 (1), 14743390 (1)
vesnarinone	22.6	6	11502643 (3), 11319194 (1)
alanine	13.5	3	2034689 (1), 7739562 (1), 19920145 (1)

Search CenterWatch for drugs/clinical trials and news about IL18R1 / IL18R

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL18R1 gene:

NM_003855.2

Unigene Cluster for IL18R1:

Interleukin 18 receptor 1

Hs.469521 [show with all ESTs]

Unigene Representative Sequence: NM_003855

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000410040 ENST00000409599(uc002tbw.4 uc010fiy.3 uc010ywc.2 uc010ywd.2)

ENST00000466357 ENST00000233957 ENST00000334376(uc010ywb.1)

miRNA Products:		OriGene 3'-UTR Clone: IL18R1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL18R1
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate IL18R1:
		hsa-miR-525-5p hsa-miR-3658 hsa-miR-377 hsa-miR-3915 hsa-miR-520a-5p hsa-miR-664
		SwitchGear 3'UTR luciferase reporter plasmid: IL18R1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL18R1 (see all 7) OriGene shRNA RFP: IL18R1 OriGene siRNA: IL18R1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL18R1

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		GenScript: all cDNA clones in your preferred vector: IL18R1 (NM_003855)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL18R1

Additional cDNA sequence:

AK313967.1 AY192162.1 BC069575.1 BC093975.1 BC093977.1 BC143403.1 BC143405.1 U43672.1

4 DOTS entries:

DT.405950 DT.100776235 DT.91854286 DT.100735658

24 AceView cDNA sequences:

AY192162 BC069575 AJ705527 AI803942 CA447335 NM_003855 CB157401 U43672

BG540341 BG541512 AI620248 AV696742 AI720021 BG570407 AI821652 BQ711554

AI734039 BX426710 BX092391 BU430024 AV684401 AA482637 AA482489 BG542027

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL18R1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAGTGAACA

About this image

IL18R1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

See IL18R1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL18R1

SOURCE GeneReport for Unigene cluster: Hs.469521

UniProtKB/Swiss-Prot: IL18R_HUMAN, Q13478

Tissue specificity: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta,

and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin

disease cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including IL18R1:

Insulin Resistance in human mouse rat

Th1/Th2 Response in human mouse rat

T Helper Cell Differentiation in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL18R1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL18R1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18R1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL18R1 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IL18R1¹	interleukin 18 receptor 1	58.07(n) 45.12(a)		418717 NM_001145225.2 NP_001138697.2
lizard (Anolis carolinensis)	Reptilia	IL18R1⁶	--	42(a)	1 ↔ 1	GL343243.1(1584242-1609154)

ENSEMBL Gene Tree for IL18R1 (if available)
TreeFam Gene Tree for IL18R1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IL18R1 gene

IL1RAPL2² IL1RL2² IL1RAP² IL1RAPL1² IL18RAP² SIGIRR² IL1R2² IL1RL1²

IL1R1²

2 SIMAP similar genes for IL18R1 using alignment to 3 protein entries: IL18R_HUMAN (see all proteins):

IL1RL1 IL1RAPL2

IL18R1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3836110^1,2	C,	--	96750006(-)	`GGGGG-/GCGGTG`	1	--	int¹		2		NA CSA	4
rs6543123^1,2	C,F,A,	--	102977196(+)	`AGTTAC/TGGAAA`	1	--	us2k¹		15		NA EU WA CSA EA	468
rs11465563^1,2	C,	--	102977236(+)	`TTAAAA/GACCCT`	1	--	us2k¹ tfbs³		4		NA EU	96
rs145716090^1,2		--	102977262(+)	`TGAGAC/TATTTA`	1	--	us2k¹		0	--	--	--	--
rs11465564^1,2	C,	--	102977372(+)	`TATAAC/ACTTAA`	1	--	us2k¹ tfbs³		5		NA EU	216
rs11465566^1,2	C,F,	--	102977405(+)	`CTTAAG/ATACAT`	1	--	us2k¹		4		NA EU WA	212
rs11123925^1,2	C,F,	--	102977511(+)	`ACTCAG/AAGTTA`	1	--	us2k¹ tfbs³		13		NA EU WA CSA EA	465
rs6710885^1,2	C,F,A,H,	--	102977537(+)	`GAGCCA/GTCTCC`	1	--	us2k¹		25		NA EU NS EA WA	2464
rs148923865^1,2		--	102977545(+)	`TCCTGA/GTAACT`	1	--	us2k¹		0	--	--	--	--
rs143837985^1,2		--	102977711(+)	`GTGGGA/GGAGGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL18R1 (102927989 - 103015218 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL18R1: --
Human Gene Mutation Database (HGMD): IL18R1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL18R1 for disorders           About GeneDecksing

OMIM gene information: 604494    OMIM disorders: --

20/123 diseases for IL18R1 (see all 123):    About MalaCards

severe combined immunodeficiency cytokine receptor deficiency anaplastic large cell lymphoma human monocytic ehrlichiosis

end stage renal failure congenital amegakaryocytic thrombocytopenia periventricular leukomalacia graft versus host disease

combined immunodeficiency laron syndrome allergic rhinitis soft tissue sarcoma

coronary heart disease leukomalacia congestive heart failure typhoid fever

lupus nephritis myeloproliferative disorder meningococcal infection collagen disease

10/91 Novoseek disease relationships for IL18R1 gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
severe combined immunodeficiency, x-linked	75.2	10	7883965 (1), 12193946 (1), 14966353 (1), 10933924 (1) (see all 8)
necrosis	64	47	8285627 (1), 9605988 (1), 11887976 (1), 9726035 (1) (see all 46)
myeloproliferative disorders	53.6	1	19293402 (1)
severe combined immunodeficiency	53.5	3	10419614 (1), 8795294 (1), 9446656 (1)
inflammation	50.5	29	10574621 (1), 11550959 (1), 11810184 (1), 12176079 (1) (see all 28)
leukemia	48	18	8217791 (2), 8276403 (1), 8943050 (1), 17522711 (1) (see all 17)
tumors	44.4	55	14598359 (2), 8285627 (1), 9605988 (1), 8519809 (1) (see all 52)
response acute phase	41.5	4	8759474 (1), 19260954 (1), 9159271 (1)
autoimmune diseases	36.9	3	20383174 (1), 17522711 (1), 8741660 (1)
laron syndrome	36.4	1	8853444 (1)

Genetic Association Database (GAD): IL18R1
Human Genome Epidemiology (HuGE) Navigator: IL18R1 (26 documents)

Export disorders for IL18R1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL18R1 gene, integrated from 9 sources (see all 924):
(articles sorted by number of sources associating them with IL18R1)

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world of online information

IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. (PubMed id 8626725)^{1, 2, 3} Parnet P.... Sims J.E. (1996)
Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PubMed id 10191101)^{1, 3, 9} Dale M. and Nicklin M.J. (1999)
Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PubMed id 16043644)^{1, 4, 9} Tiret L....Blankenberg S. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
Purification and characterization of the human interleukin-18 receptor. (PubMed id 9325300)^{1, 2} Torigoe K.... Kurimoto M. (1997)
Lack of association between polymorphisms of the IL18 R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PubMed id 19473509)^{1, 9} Grisoni M.L....Tregouet D.A. (2009)
IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. (PubMed id 16971411)^{1, 9} Nadif R....Kleeberger S.R. (2006)
IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. (PubMed id 10925275)^{1, 9} Sareneva T.... Matikainen S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8809	HGNC: 5988	AceView: IL18R1	Ensembl:ENSG00000115604	euGenes: HUgn8809
ECgene: IL18R1	Kegg: 8809	H-InvDB: IL18R1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL18R1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL18R1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for IL18R1 gene
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Patent Information for IL18R1 gene:
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interleukin 18 receptor 1

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IL18R1 Gene

interleukin 18 receptor 1

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