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Aliases for IL18R1 Gene

Aliases for IL18R1 Gene

  • Interleukin 18 Receptor 1 2 3
  • CD218 Antigen-Like Family Member A 3 4
  • IL1 Receptor-Related Protein 3 4
  • IL-18R-1 3 4
  • CDw218a 3 4
  • IL-18R1 3 4
  • IL-1Rrp 3 4
  • IL1R-Rp 3 4
  • IL1RRP 3 4
  • Cytokine Receptor 3
  • CD218a Antigen 4
  • IL18Ralpha2 3
  • CD218a 3
  • IL18RA 3

External Ids for IL18R1 Gene

Previous GeneCards Identifiers for IL18R1 Gene

  • GC02P100843
  • GC02P101431
  • GC02P102583
  • GC02P102600
  • GC02P102437
  • GC02P102928
  • GC02P096744

Summaries for IL18R1 Gene

Entrez Gene Summary for IL18R1 Gene

  • The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for IL18R1 Gene

IL18R1 (Interleukin 18 Receptor 1) is a Protein Coding gene. Diseases associated with IL18R1 include smallpox and joint disorders. Among its related pathways are Akt Signaling and PAK Pathway. GO annotations related to this gene include receptor activity and interleukin-18 receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL18R1 Gene

  • Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B

Gene Wiki entry for IL18R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18R1 Gene

Genomics for IL18R1 Gene

Regulatory Elements for IL18R1 Gene

Genomic Location for IL18R1 Gene

Chromosome:
2
Start:
102,311,529 bp from pter
End:
102,398,777 bp from pter
Size:
87,249 bases
Orientation:
Plus strand

Genomic View for IL18R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL18R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18R1 Gene

Proteins for IL18R1 Gene

  • Protein details for IL18R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13478-IL18R_HUMAN
    Recommended name:
    Interleukin-18 receptor 1
    Protein Accession:
    Q13478
    Secondary Accessions:
    • B2R9Y5
    • Q52LC9

    Protein attributes for IL18R1 Gene

    Size:
    541 amino acids
    Molecular mass:
    62304 Da
    Quaternary structure:
    • Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta

    Three dimensional structures from OCA and Proteopedia for IL18R1 Gene

neXtProt entry for IL18R1 Gene

Proteomics data for IL18R1 Gene at MOPED

Post-translational modifications for IL18R1 Gene

  • Glycosylation at Asn 91, Asn 102, Asn 150, Asn 197, Asn 203, Asn 236, Asn 255, and Asn 297
  • Modification sites at PhosphoSitePlus

Other Protein References for IL18R1 Gene

Antibody Products

  • R&D Systems Antibodies for IL18R1 (IL-18 R alpha/IL-1 R5)

No data available for DME Specific Peptides for IL18R1 Gene

Domains & Families for IL18R1 Gene

Suggested Antigen Peptide Sequences for IL18R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13478

UniProtKB/Swiss-Prot:

IL18R_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL18R1: view

Function for IL18R1 Gene

Molecular function for IL18R1 Gene

GENATLAS Biochemistry:
interleukin 18 receptor 1,type 1
UniProtKB/Swiss-Prot Function:
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B

Gene Ontology (GO) - Molecular Function for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9325300
GO:0004908 interleukin-1 receptor activity IEA --
GO:0005515 protein binding IPI 25261253
GO:0042008 interleukin-18 receptor activity IEA --
genes like me logo Genes that share ontologies with IL18R1: view
genes like me logo Genes that share phenotypes with IL18R1: view

Animal Models for IL18R1 Gene

MGI Knock Outs for IL18R1:

Animal Model Products

miRNA for IL18R1 Gene

miRTarBase miRNAs that target IL18R1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL18R1 Gene

Localization for IL18R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18R1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL18R1 Gene COMPARTMENTS Subcellular localization image for IL18R1 gene
Compartment Confidence
plasma membrane 4
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9325300
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL18R1: view

Pathways & Interactions for IL18R1 Gene

genes like me logo Genes that share pathways with IL18R1: view

PCR Array Products

SIGNOR curated interactions for IL18R1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9325300
GO:0007165 signal transduction TAS 9325300
GO:0030101 natural killer cell activation IEA --
GO:0032729 positive regulation of interferon-gamma production IEA --
GO:0035655 interleukin-18-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL18R1: view

Drugs & Compounds for IL18R1 Gene

(40) Drugs for IL18R1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Clozapine Approved Pharma Antagonist Antipsychotic medication 108
Dexamethasone Approved, Investigational Pharma Agonist 1806
Etanercept Approved, Investigational Pharma 0
Ethanol Approved Pharma 1708

(31) Additional Compounds for IL18R1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
adenylate
Ceramide
3102-57-6
Endotoxin
glucose
genes like me logo Genes that share compounds with IL18R1: view

Transcripts for IL18R1 Gene

Unigene Clusters for IL18R1 Gene

Interleukin 18 receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18R1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18R1 Gene

No ASD Table

Relevant External Links for IL18R1 Gene

GeneLoc Exon Structure for
IL18R1
ECgene alternative splicing isoforms for
IL18R1

Expression for IL18R1 Gene

mRNA expression in normal human tissues for IL18R1 Gene

mRNA differential expression in normal tissues according to GTEx for IL18R1 Gene

This gene is overexpressed in Whole Blood (x20.4) and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for IL18R1 Gene

This gene is overexpressed in Adrenal (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL18R1 Gene



SOURCE GeneReport for Unigene cluster for IL18R1 Gene Hs.469521

mRNA Expression by UniProt/SwissProt for IL18R1 Gene

Q13478-IL18R_HUMAN
Tissue specificity: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines
genes like me logo Genes that share expression patterns with IL18R1: view

Protein tissue co-expression partners for IL18R1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL18R1 Gene

Orthologs for IL18R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL18R1 35
  • 82.81 (n)
  • 75.61 (a)
IL18R1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL18R1 35
  • 83.65 (n)
  • 74.62 (a)
IL18R1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il18r1 35
  • 72.67 (n)
  • 65.29 (a)
Il18r1 16
Il18r1 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL18R1 35
  • 99.17 (n)
  • 98.46 (a)
IL18R1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il18r1 35
  • 72.66 (n)
  • 65.92 (a)
oppossum
(Monodelphis domestica)
Mammalia IL18R1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IL18R1 35
  • 58.07 (n)
  • 45.31 (a)
IL18R1 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL18R1 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732855 35
  • 54.33 (n)
  • 41.49 (a)
Species with no ortholog for IL18R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18R1 Gene

ENSEMBL:
Gene Tree for IL18R1 (if available)
TreeFam:
Gene Tree for IL18R1 (if available)

Paralogs for IL18R1 Gene

Paralogs for IL18R1 Gene

(2) SIMAP similar genes for IL18R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL18R1: view

Variants for IL18R1 Gene

Sequence variations from dbSNP and Humsavar for IL18R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs881890 -- 102,386,854(+) GCCCT(C/T)TTACA intron-variant
rs1035130 -- 102,384,942(-) TCCCC(A/G)AACAT reference, synonymous-codon, nc-transcript-variant
rs1057336 -- 102,398,526(+) AATAA(C/T)TTAAT utr-variant-3-prime
rs1135354 -- 102,397,842(+) TTCTG(G/T)GGCCT utr-variant-3-prime
rs1362348 -- 102,368,164(-) ATGTG(C/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL18R1 Gene

Variant ID Type Subtype PubMed ID
nsv2856 CNV Loss 18451855

Variation tolerance for IL18R1 Gene

Residual Variation Intolerance Score: 18.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL18R1 Gene

HapMap Linkage Disequilibrium report
IL18R1
Human Gene Mutation Database (HGMD)
IL18R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18R1 Gene

Disorders for IL18R1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for IL18R1 Gene - From: DISEASES, NovoSeek, and GeneCards

- elite association

Relevant External Links for IL18R1

Genetic Association Database (GAD)
IL18R1
Human Genome Epidemiology (HuGE) Navigator
IL18R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL18R1
genes like me logo Genes that share disorders with IL18R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18R1 Gene

Publications for IL18R1 Gene

  1. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 23 67
  2. Sensing invasion: cell surface receptors driving spreading of glioblastoma. (PMID: 19688773) Teodorczyk M. … Martin-Villalba A. (J. Cell. Physiol. 2010) 23 67
  3. Rapid, simple and high yield production of recombinant proteins in mammalian cells using a versatile episomal system. (PMID: 20399863) Magistrelli G. … Fischer N. (Protein Expr. Purif. 2010) 23 67
  4. Molecular dissection of human interleukin-31-mediated signal transduction through site-directed mutagenesis. (PMID: 19920145) Le Saux S. … Gascan H. (J. Biol. Chem. 2010) 23 67
  5. A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F). (PMID: 19929856) Zhao L. … Huang L.J. (Biochem. J. 2010) 23 67

Products for IL18R1 Gene

Sources for IL18R1 Gene

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