Aliases for IL18R1 Gene
External Ids for IL18R1 Gene
Previous GeneCards Identifiers for IL18R1 Gene
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for IL18R1 Gene
IL18R1 (Interleukin 18 Receptor 1) is a Protein Coding gene. Diseases associated with IL18R1 include smallpox and joint disorders. Among its related pathways are Akt Signaling and PAK Pathway. GO annotations related to this gene include receptor activity and interleukin-18 receptor activity. An important paralog of this gene is IL1RAP.
UniProtKB/Swiss-Prot for IL18R1 Gene
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B