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Aliases for IL18R1 Gene

Aliases for IL18R1 Gene

  • Interleukin 18 Receptor 1 2 3 5
  • CD218 Antigen-Like Family Member A 3 4
  • IL1 Receptor-Related Protein 3 4
  • IL-18R-1 3 4
  • CDw218a 3 4
  • IL-18R1 3 4
  • IL-1Rrp 3 4
  • IL1R-Rp 3 4
  • IL1RRP 3 4
  • Cytokine Receptor 3
  • CD218a Antigen 4
  • IL18Ralpha2 3
  • CD218a 3
  • IL18RA 3

External Ids for IL18R1 Gene

Previous GeneCards Identifiers for IL18R1 Gene

  • GC02P100843
  • GC02P101431
  • GC02P102583
  • GC02P102600
  • GC02P102437
  • GC02P102928
  • GC02P096744

Summaries for IL18R1 Gene

Entrez Gene Summary for IL18R1 Gene

  • The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for IL18R1 Gene

IL18R1 (Interleukin 18 Receptor 1) is a Protein Coding gene. Diseases associated with IL18R1 include Smallpox and Severe Combined Immunodeficiency, X-Linked. Among its related pathways are Toll-Like receptor Signaling Pathways and TNF signaling pathway. GO annotations related to this gene include receptor activity and interleukin-18 receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL18R1 Gene

  • Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

Gene Wiki entry for IL18R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18R1 Gene

Genomics for IL18R1 Gene

Regulatory Elements for IL18R1 Gene

Enhancers for IL18R1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL18R1 on UCSC Golden Path with GeneCards custom track

Promoters for IL18R1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL18R1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL18R1 Gene

102,311,529 bp from pter
102,398,777 bp from pter
87,249 bases
Plus strand

Genomic View for IL18R1 Gene

Genes around IL18R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18R1 Gene

Proteins for IL18R1 Gene

  • Protein details for IL18R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-18 receptor 1
    Protein Accession:
    Secondary Accessions:
    • B2R9Y5
    • Q52LC9

    Protein attributes for IL18R1 Gene

    541 amino acids
    Molecular mass:
    62304 Da
    Quaternary structure:
    • Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

    Three dimensional structures from OCA and Proteopedia for IL18R1 Gene

neXtProt entry for IL18R1 Gene

Proteomics data for IL18R1 Gene at MOPED

Post-translational modifications for IL18R1 Gene

  • Glycosylation at Asn 91, Asn 102, Asn 150, Asn 197, Asn 203, Asn 236, Asn 255, and Asn 297
  • Modification sites at PhosphoSitePlus

Other Protein References for IL18R1 Gene

Antibody Products

  • R&D Systems Antibodies for IL18R1 (IL-18 R alpha/IL-1 R5)

No data available for DME Specific Peptides for IL18R1 Gene

Domains & Families for IL18R1 Gene

Suggested Antigen Peptide Sequences for IL18R1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the interleukin-1 receptor family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL18R1: view

Function for IL18R1 Gene

Molecular function for IL18R1 Gene

GENATLAS Biochemistry:
interleukin 18 receptor 1,type 1
UniProtKB/Swiss-Prot Function:
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
genes like me logo Genes that share phenotypes with IL18R1: view

Animal Models for IL18R1 Gene

MGI Knock Outs for IL18R1:

Animal Model Products

miRNA for IL18R1 Gene

miRTarBase miRNAs that target IL18R1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18R1 Gene

Localization for IL18R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18R1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL18R1 Gene COMPARTMENTS Subcellular localization image for IL18R1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
peroxisome 2
cytosol 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IL18R1 Gene

Pathways & Interactions for IL18R1 Gene

genes like me logo Genes that share pathways with IL18R1: view

SIGNOR curated interactions for IL18R1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9325300
GO:0007165 signal transduction IEA,TAS 9325300
GO:0045063 T-helper 1 cell differentiation IEA --
genes like me logo Genes that share ontologies with IL18R1: view

Drugs & Compounds for IL18R1 Gene

(40) Drugs for IL18R1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(31) Additional Compounds for IL18R1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL18R1: view

Transcripts for IL18R1 Gene

Unigene Clusters for IL18R1 Gene

Interleukin 18 receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL18R1 Gene

No ASD Table

Relevant External Links for IL18R1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL18R1 Gene

mRNA expression in normal human tissues for IL18R1 Gene

mRNA differential expression in normal tissues according to GTEx for IL18R1 Gene

This gene is overexpressed in Whole Blood (x20.4) and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for IL18R1 Gene

This gene is overexpressed in Adrenal (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL18R1 Gene

SOURCE GeneReport for Unigene cluster for IL18R1 Gene Hs.469521

mRNA Expression by UniProt/SwissProt for IL18R1 Gene

Tissue specificity: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines.
genes like me logo Genes that share expression patterns with IL18R1: view

Protein tissue co-expression partners for IL18R1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL18R1 Gene

Orthologs for IL18R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18R1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL18R1 35
  • 82.81 (n)
  • 75.61 (a)
IL18R1 36
  • 75 (a)
(Canis familiaris)
Mammalia IL18R1 35
  • 83.65 (n)
  • 74.62 (a)
IL18R1 36
  • 73 (a)
(Mus musculus)
Mammalia Il18r1 35
  • 72.67 (n)
  • 65.29 (a)
Il18r1 16
Il18r1 36
  • 64 (a)
(Pan troglodytes)
Mammalia IL18R1 35
  • 99.17 (n)
  • 98.46 (a)
IL18R1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Il18r1 35
  • 72.66 (n)
  • 65.92 (a)
(Monodelphis domestica)
Mammalia IL18R1 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
(Gallus gallus)
Aves IL18R1 35
  • 58.07 (n)
  • 45.31 (a)
IL18R1 36
  • 40 (a)
(Anolis carolinensis)
Reptilia IL18R1 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732855 35
  • 54.33 (n)
  • 41.49 (a)
Species with no ortholog for IL18R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18R1 Gene

Gene Tree for IL18R1 (if available)
Gene Tree for IL18R1 (if available)

Paralogs for IL18R1 Gene

Paralogs for IL18R1 Gene

(2) SIMAP similar genes for IL18R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL18R1: view

Variants for IL18R1 Gene

Sequence variations from dbSNP and Humsavar for IL18R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11465635 - 102,381,623(+) AGATC(A/G/T)CAGTA nc-transcript-variant, reference, missense
rs11465644 - 102,384,885(+) AAAAA(A/C/T)GTAAG nc-transcript-variant, reference, missense
rs11465648 - 102,386,980(+) CAAAA(A/G)CTTCA nc-transcript-variant, reference, missense
rs12619169 - 102,394,624(+) CTGGA(A/G)GAGGT intron-variant, reference, missense
rs1558627 -- 102,368,224(-) TTATT(C/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL18R1 Gene

Variant ID Type Subtype PubMed ID
nsv2856 CNV Loss 18451855

Variation tolerance for IL18R1 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL18R1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18R1 Gene

Disorders for IL18R1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IL18R1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
severe combined immunodeficiency, x-linked
  • xscid
acute basophilic leukemia
  • pneumoconiosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL18R1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL18R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18R1 Gene

Publications for IL18R1 Gene

  1. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. (PMID: 8626725) Parnet P. … Sims J.E. (J. Biol. Chem. 1996) 2 3 4 67
  2. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 23
  3. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PMID: 19473509) Grisoni M.L. … Tregouet D.A. (BMC Med. Genet. 2009) 3 23
  4. IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. (PMID: 16971411) Nadif R. … Kleeberger S.R. (Eur. Respir. J. 2006) 3 23
  5. A major population of mucosal memory CD4+ T cells, coexpressing IL-18RI+ and DR3, display innate lymphocyte functionality. (PMID: 25269704) Holmkvist P. … Agace W.W. (Mucosal Immunol 2015) 3

Products for IL18R1 Gene

Sources for IL18R1 Gene