Aliases for IL18R1 Gene
External Ids for IL18R1 Gene
Previous GeneCards Identifiers for IL18R1 Gene
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for IL18R1 Gene
IL18R1 (Interleukin 18 Receptor 1) is a Protein Coding gene. Diseases associated with IL18R1 include Smallpox and Severe Combined Immunodeficiency, X-Linked. Among its related pathways are Toll-Like receptor Signaling Pathways and TNF signaling pathway. GO annotations related to this gene include receptor activity and interleukin-18 receptor activity. An important paralog of this gene is IL1RAP.
UniProtKB/Swiss-Prot for IL18R1 Gene
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.