Aliases for IL18R1 Gene
External Ids for IL18R1 Gene
Previous GeneCards Identifiers for IL18R1 Gene
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for IL18R1 Gene
IL18R1 (Interleukin 18 Receptor 1) is a Protein Coding gene. Diseases associated with IL18R1 include Smallpox and Severe Combined Immune Deficiency. Among its related pathways are Immune response_IL-12 signaling pathway and PEDF Induced Signaling. GO annotations related to this gene include receptor activity and interleukin-18 receptor activity. An important paralog of this gene is IL1RAPL2.
UniProtKB/Swiss-Prot for IL18R1 Gene
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).