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Aliases for IL18R1 Gene

Aliases for IL18R1 Gene

  • Interleukin 18 Receptor 1 2 3
  • IL1RRP 3 4 6
  • CD218 Antigen-Like Family Member A 3 4
  • IL1 Receptor-Related Protein 3 4
  • IL-18R-1 3 4
  • CDw218a 3 4
  • IL-18R1 3 4
  • IL-1Rrp 3 4
  • IL1R-Rp 3 4
  • Interleukin-18 Receptor 1 3
  • Cytokine Receptor 3
  • CD218a Antigen 4
  • IL18Ralpha2 3
  • CD218a 3
  • IL18RA 3

External Ids for IL18R1 Gene

Previous GeneCards Identifiers for IL18R1 Gene

  • GC02P100843
  • GC02P101431
  • GC02P102583
  • GC02P102600
  • GC02P102437
  • GC02P102928
  • GC02P096744

Summaries for IL18R1 Gene

Entrez Gene Summary for IL18R1 Gene

  • The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for IL18R1 Gene

IL18R1 (Interleukin 18 Receptor 1) is a Protein Coding gene. Diseases associated with IL18R1 include collagen disease and joint disorders. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor activity and interleukin-18 receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL18R1 Gene

  • Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B

Gene Wiki entry for IL18R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18R1 Gene

Genomics for IL18R1 Gene

Regulatory Elements for IL18R1 Gene

Genomic Location for IL18R1 Gene

102,311,529 bp from pter
102,398,775 bp from pter
87,247 bases
Plus strand

Genomic View for IL18R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL18R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18R1 Gene

Proteins for IL18R1 Gene

  • Protein details for IL18R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-18 receptor 1
    Protein Accession:
    Secondary Accessions:
    • B2R9Y5
    • Q52LC9

    Protein attributes for IL18R1 Gene

    541 amino acids
    Molecular mass:
    62304 Da
    Quaternary structure:
    • Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta

    Three dimensional structures from OCA and Proteopedia for IL18R1 Gene

neXtProt entry for IL18R1 Gene

Proteomics data for IL18R1 Gene at MOPED

Post-translational modifications for IL18R1 Gene

  • Glycosylation at Asn91, Asn102, Asn150, Asn197, Asn203, Asn236, Asn255, and Asn297
  • Modification sites at PhosphoSitePlus

Other Protein References for IL18R1 Gene

Antibody Products

  • R&D Systems Antibodies for IL18R1 (IL-18 R alpha/IL-1 R5)

No data available for DME Specific Peptides for IL18R1 Gene

Domains for IL18R1 Gene

Gene Families for IL18R1 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors

Suggested Antigen Peptide Sequences for IL18R1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q13478
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL18R1: view

Function for IL18R1 Gene

Molecular function for IL18R1 Gene

GENATLAS Biochemistry:
interleukin 18 receptor 1,type 1
UniProtKB/Swiss-Prot Function:
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B

Gene Ontology (GO) - Molecular Function for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9325300
GO:0004908 interleukin-1 receptor activity IEA --
GO:0005515 protein binding IPI 25261253
GO:0042008 interleukin-18 receptor activity IEA --
genes like me logo Genes that share ontologies with IL18R1: view

Phenotypes for IL18R1 Gene

MGI mutant phenotypes for IL18R1:
inferred from 1 alleles
GenomeRNAi human phenotypes for IL18R1:
genes like me logo Genes that share phenotypes with IL18R1: view

Animal Models for IL18R1 Gene

MGI Knock Outs for IL18R1:

Animal Model Products

miRNA for IL18R1 Gene

miRTarBase miRNAs that target IL18R1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL18R1 Gene

Localization for IL18R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18R1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL18R1 Gene COMPARTMENTS Subcellular localization image for IL18R1 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9325300
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL18R1: view

Pathways for IL18R1 Gene

genes like me logo Genes that share pathways with IL18R1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9325300
GO:0007165 signal transduction TAS 9325300
GO:0030101 natural killer cell activation IEA --
GO:0032729 positive regulation of interferon-gamma production IEA --
GO:0035655 interleukin-18-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL18R1: view

Compounds for IL18R1 Gene

(71) Novoseek inferred chemical compound relationships for IL18R1 Gene

Compound -log(P) Hits PubMed IDs
gp 130 85.9 37
tyrosine 78.1 111
phosphotyrosine 53.4 7
neopterin 39.7 11
propanil 39.6 3
genes like me logo Genes that share compounds with IL18R1: view

Transcripts for IL18R1 Gene

Unigene Clusters for IL18R1 Gene

Interleukin 18 receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18R1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18R1 Gene

No ASD Table

Relevant External Links for IL18R1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL18R1 Gene

mRNA expression in normal human tissues for IL18R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18R1 Gene

This gene is overexpressed in Whole Blood (20.4) and Lung (4.0).

Protein differential expression in normal tissues for IL18R1 Gene

This gene is overexpressed in Adrenal (49.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL18R1 Gene

SOURCE GeneReport for Unigene cluster for IL18R1 Gene Hs.469521

mRNA Expression by UniProt/SwissProt for IL18R1 Gene

Tissue specificity: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines
genes like me logo Genes that share expressions with IL18R1: view

Expression partners for IL18R1 Gene

In Situ Assay Products

Orthologs for IL18R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18R1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL18R1 35
  • 82.81 (n)
  • 75.61 (a)
IL18R1 36
  • 75 (a)
(Canis familiaris)
Mammalia IL18R1 35
  • 83.65 (n)
  • 74.62 (a)
IL18R1 36
  • 73 (a)
(Mus musculus)
Mammalia Il18r1 35
  • 72.67 (n)
  • 65.29 (a)
Il18r1 16
Il18r1 36
  • 64 (a)
(Pan troglodytes)
Mammalia IL18R1 35
  • 99.17 (n)
  • 98.46 (a)
IL18R1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Il18r1 35
  • 72.66 (n)
  • 65.92 (a)
(Monodelphis domestica)
Mammalia IL18R1 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
(Gallus gallus)
Aves IL18R1 35
  • 58.07 (n)
  • 45.31 (a)
IL18R1 36
  • 40 (a)
(Anolis carolinensis)
Reptilia IL18R1 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732855 35
  • 54.33 (n)
  • 41.49 (a)
Species with no ortholog for IL18R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18R1 Gene

Gene Tree for IL18R1 (if available)
Gene Tree for IL18R1 (if available)

Paralogs for IL18R1 Gene

Paralogs for IL18R1 Gene

Selected SIMAP similar genes for IL18R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL18R1: view

Variants for IL18R1 Gene

Sequence variations from dbSNP and Humsavar for IL18R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs113144768 -- 102,396,720(+) GCCCC(A/G)ATCAC reference, missense
rs113247825 -- 102,395,257(+) CTTTT(C/T)AATGA intron-variant
rs113255823 -- 102,371,268(+) GATCC(A/T)CCTGC intron-variant
rs113274163 -- 102,371,812(+) GGCAG(A/G)GCAGG intron-variant
rs113335628 -- 102,382,240(+) GCACT(A/C)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL18R1 Gene

Variant ID Type Subtype PubMed ID
nsv2856 CNV Loss 18451855

Relevant External Links for IL18R1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18R1 Gene

Disorders for IL18R1 Gene

(91) Novoseek inferred disease relationships for IL18R1 Gene

Disease -log(P) Hits PubMed IDs
severe combined immunodeficiency, x-linked 75.2 8
necrosis 64 46
myeloproliferative disorders 53.6 1
severe combined immunodeficiency 53.5 3
inflammation 50.5 28

Relevant External Links for IL18R1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL18R1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for IL18R1 Gene

Publications for IL18R1 Gene

  1. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 23
  2. IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. (PMID: 16971411) Nadif R. … Kleeberger S.R. (Eur. Respir. J. 2006) 3 23 48
  3. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. (PMID: 18774397) Reijmerink N.E. … Koppelman G.H. (J. Allergy Clin. Immunol. 2008) 3 23 48
  4. Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. (PMID: 18382474) Zhu G. … Pillai S.G. (Eur. J. Hum. Genet. 2008) 3 23 48
  5. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PMID: 19473509) Grisoni M.L. … Tregouet D.A. (BMC Med. Genet. 2009) 3 23 48

Products for IL18R1 Gene

Sources for IL18R1 Gene

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