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Aliases for IL18BP Gene

Aliases for IL18BP Gene

  • Interleukin 18 Binding Protein 2 3 5
  • MC51L-53L-54L Homolog Gene Product 2 3
  • Tadekinig-Alfa 3 4
  • IL-18BP 3 4
  • Interleukin-18-Binding Protein 3
  • IL18BPa 3

External Ids for IL18BP Gene

Previous GeneCards Identifiers for IL18BP Gene

  • GC11P074042
  • GC11P073248
  • GC11P071931
  • GC11P071435
  • GC11P071436
  • GC11P071387
  • GC11P071709
  • GC11P068003

Summaries for IL18BP Gene

Entrez Gene Summary for IL18BP Gene

  • The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL18BP Gene

IL18BP (Interleukin 18 Binding Protein) is a Protein Coding gene. Diseases associated with IL18BP include Molluscum Contagiosum and Hypoplastic Or Aplastic Tibia With Polydactyly. Among its related pathways are Innate Immune System and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include receptor antagonist activity and interleukin-18 binding.

UniProtKB/Swiss-Prot for IL18BP Gene

  • Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Gene Wiki entry for IL18BP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18BP Gene

Genomics for IL18BP Gene

Regulatory Elements for IL18BP Gene

Enhancers for IL18BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G071942 1.6 Ensembl ENCODE dbSUPER 10.8 -51.4 -51437 7.3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 FOS KAT8 MEF2D MIER3 LOC100128494 NUMA1 IL18BP LRTOMT FAM86C1 PIR62264
GH11G072037 1.3 ENCODE dbSUPER 10.5 +42.9 42906 6.7 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 YY1 SLC30A9 NUMA1 LRTOMT FAM86C1 LOC100128494 LAMTOR1 ANAPC15 FOLR3 IL18BP RNF121 PHOX2A
GH11G072143 1.3 Ensembl ENCODE dbSUPER 10 +146.8 146765 2.8 RB1 RAD21 RFX5 SCRT2 ZNF143 FOS CREM ZNF654 CEBPB REST FOLR3 ANAPC15 LAMTOR1 LRTOMT NUMA1 LOC100128494 PHOX2A RNF121 IL18BP FAM86C1
GH11G072023 1.1 ENCODE dbSUPER 10.8 +27.0 26995 3.0 HDGF RB1 ARID4B SIN3A ZNF2 ZNF48 RAD21 ZNF121 ZNF143 FOS LRTOMT NUMA1 IL18BP ANAPC15 RNF121 LAMTOR1 PHOX2A FAM86C1 PIR48139 GC11M072049
GH11G072139 1.1 Ensembl ENCODE dbSUPER 10.5 +143.4 143398 2.9 FOSL1 GTF3C2 JUND JUN BHLHE40 MAX FOS FOLR3 LOC100128494 LAMTOR1 LOC100133315 ZNF705E ANAPC15 LRTOMT OR7E128P NADSYN1 IL18BP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL18BP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL18BP gene promoter:

Genomic Location for IL18BP Gene

Chromosome:
11
Start:
71,997,944 bp from pter
End:
72,005,715 bp from pter
Size:
7,772 bases
Orientation:
Plus strand

Genomic View for IL18BP Gene

Genes around IL18BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18BP Gene

Proteins for IL18BP Gene

  • Protein details for IL18BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95998-I18BP_HUMAN
    Recommended name:
    Interleukin-18-binding protein
    Protein Accession:
    O95998
    Secondary Accessions:
    • B3KUZ0
    • B7WPK4
    • O95993
    • O96027
    • Q9NZA9
    • Q9UBR7

    Protein attributes for IL18BP Gene

    Size:
    194 amino acids
    Molecular mass:
    21099 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD17187.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17189.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAD17190.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17192.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAF31697.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL18BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL18BP Gene

Post-translational modifications for IL18BP Gene

  • N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.
  • Glycosylation at posLast=4646, isoforms=3, 447, posLast=5353, isoforms=479, isoforms=494, posLast=103103, and posLast=147147
  • Modification sites at PhosphoSitePlus

Antibody Products

Assay Products

No data available for DME Specific Peptides for IL18BP Gene

Domains & Families for IL18BP Gene

Gene Families for IL18BP Gene

Protein Domains for IL18BP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL18BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL18BP: view

No data available for UniProtKB/Swiss-Prot for IL18BP Gene

Function for IL18BP Gene

Molecular function for IL18BP Gene

GENATLAS Biochemistry:
interleukin 18 binding protein homolog to several poxvirus proteins,expressed in the spleen inhibitor of the early Th1 cytokine response,abolishing IL18 induction of INF gamma
UniProtKB/Swiss-Prot Function:
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Gene Ontology (GO) - Molecular Function for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042007 interleukin-18 binding IDA 10023777
GO:0048019 receptor antagonist activity TAS 11890646
genes like me logo Genes that share ontologies with IL18BP: view
genes like me logo Genes that share phenotypes with IL18BP: view

Animal Models for IL18BP Gene

MGI Knock Outs for IL18BP:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL18BP

CRISPR Products

miRNA for IL18BP Gene

miRTarBase miRNAs that target IL18BP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18BP Gene

Localization for IL18BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18BP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL18BP gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10023777
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IL18BP: view

Pathways & Interactions for IL18BP Gene

genes like me logo Genes that share pathways with IL18BP: view

Pathways by source for IL18BP Gene

Gene Ontology (GO) - Biological Process for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032496 response to lipopolysaccharide IEA --
GO:0042088 T-helper 1 type immune response IDA 10023777
GO:0070301 cellular response to hydrogen peroxide IEA --
GO:0071356 cellular response to tumor necrosis factor IEA --
GO:1900116 extracellular negative regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with IL18BP: view

No data available for SIGNOR curated interactions for IL18BP Gene

Drugs & Compounds for IL18BP Gene

(1) Drugs for IL18BP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for IL18BP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL18BP: view

Transcripts for IL18BP Gene

Unigene Clusters for IL18BP Gene

Interleukin 18 binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18BP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: - - -
SP6:
SP7: -

Relevant External Links for IL18BP Gene

GeneLoc Exon Structure for
IL18BP
ECgene alternative splicing isoforms for
IL18BP

Expression for IL18BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL18BP Gene

Protein differential expression in normal tissues from HIPED for IL18BP Gene

This gene is overexpressed in Serum (42.2) and Urine (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL18BP Gene



Protein tissue co-expression partners for IL18BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL18BP Gene:

IL18BP

SOURCE GeneReport for Unigene cluster for IL18BP Gene:

Hs.591967

mRNA Expression by UniProt/SwissProt for IL18BP Gene:

O95998-I18BP_HUMAN
Tissue specificity: Strongly expressed in heart, lung, placenta and spleen.

Evidence on tissue expression from TISSUES for IL18BP Gene

  • Blood(4.4)
  • Intestine(2.6)
  • Spleen(2.3)
  • Kidney(2.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with IL18BP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL18BP Gene

Orthologs for IL18BP Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL18BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL18BP 34 35
  • 99.14 (n)
cow
(Bos Taurus)
Mammalia IL18BP 34 35
  • 80.65 (n)
mouse
(Mus musculus)
Mammalia Il18bp 34 16 35
  • 78.02 (n)
rat
(Rattus norvegicus)
Mammalia Il18bp 34
  • 75.09 (n)
dog
(Canis familiaris)
Mammalia IL18BP 34 35
  • 75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL18BP 35
  • 35 (a)
OneToOne
Species where no ortholog for IL18BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18BP Gene

ENSEMBL:
Gene Tree for IL18BP (if available)
TreeFam:
Gene Tree for IL18BP (if available)

Paralogs for IL18BP Gene

No data available for Paralogs for IL18BP Gene

Variants for IL18BP Gene

Sequence variations from dbSNP and Humsavar for IL18BP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000120970 -- 72,001,986(+) CTTCT(C/T)TGCTT utr-variant-3-prime
rs1000716402 -- 72,000,813(+) TGCAG(C/T)GGACC intron-variant
rs1000969227 -- 72,002,719(+) CTAAT(A/G)GAGAG downstream-variant-500B, utr-variant-3-prime
rs1001266929 -- 71,998,995(+) GAAGG(C/G)TCTTC upstream-variant-2KB, utr-variant-5-prime
rs1001373065 -- 71,997,103(+) CTTGT(A/G)CAAGC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IL18BP Gene

Variant ID Type Subtype PubMed ID
nsv428262 CNV gain+loss 18775914
nsv951037 CNV deletion 24416366

Variation tolerance for IL18BP Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL18BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL18BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18BP Gene

Disorders for IL18BP Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL18BP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
molluscum contagiosum
hypoplastic or aplastic tibia with polydactyly
  • tibia, hypoplasia or aplasia of, with polydactyly
crohn's disease
  • ileitis
wegener granulomatosis
  • wegener's granulomatosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL18BP

Genetic Association Database (GAD)
IL18BP
Human Genome Epidemiology (HuGE) Navigator
IL18BP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL18BP
genes like me logo Genes that share disorders with IL18BP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18BP Gene

Publications for IL18BP Gene

  1. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. (PMID: 10023777) Novick D. … Rubinstein M. (Immunity 1999) 2 3 4 22 64
  2. Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men. (PMID: 17951325) Thompson S.R. … Humphries S.E. (Arterioscler. Thromb. Vasc. Biol. 2007) 3 22 46 64
  3. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. (PMID: 10655506) Kim S.-H. … Dinarello C.A. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 22 64
  4. Cloning and expression of interleukin-18 binding protein. (PMID: 10094485) Aizawa Y. … Kurimoto M. (FEBS Lett. 1999) 3 4 22 64
  5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64

Products for IL18BP Gene

Sources for IL18BP Gene

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