Aliases for IL18BP Gene
External Ids for IL18BP Gene
Previous GeneCards Identifiers for IL18BP Gene
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for IL18BP Gene
IL18BP (Interleukin 18 Binding Protein) is a Protein Coding gene. Diseases associated with IL18BP include Crohn's Disease and Wegener Granulomatosis. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include receptor antagonist activity and interleukin-18 binding.
UniProtKB/Swiss-Prot for IL18BP Gene
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.