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Aliases for IL18BP Gene

Aliases for IL18BP Gene

  • Interleukin 18 Binding Protein 2 3
  • MC51L-53L-54L Homolog Gene Product 2 3
  • Tadekinig-Alfa 3 4
  • IL-18BP 3 4
  • Interleukin-18-Binding Protein 3
  • IL18BPa 3

External Ids for IL18BP Gene

Summaries for IL18BP Gene

Entrez Gene Summary for IL18BP Gene

  • The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL18BP Gene

IL18BP (Interleukin 18 Binding Protein) is a Protein Coding gene. Diseases associated with IL18BP include smallpox and acute graft versus host disease. Among its related pathways are NOD-like Receptor Signaling Pathways. GO annotations related to this gene include receptor antagonist activity and interleukin-18 binding.

UniProtKB/Swiss-Prot for IL18BP Gene

  • Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Gene Wiki entry for IL18BP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18BP Gene

Genomics for IL18BP Gene

Genomic Location for IL18BP Gene

Start:
71,998,541 bp from pter
End:
72,005,715 bp from pter
Size:
7,175 bases
Orientation:
Plus strand

Genomic View for IL18BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL18BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18BP Gene

Regulatory Elements for IL18BP Gene

Transcription factor binding sites by QIAGEN in the IL18BP gene promoter:

Proteins for IL18BP Gene

  • Protein details for IL18BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95998-I18BP_HUMAN
    Recommended name:
    Interleukin-18-binding protein
    Protein Accession:
    O95998
    Secondary Accessions:
    • B3KUZ0
    • B7WPK4
    • O95993
    • O96027
    • Q9NZA9
    • Q9UBR7

    Protein attributes for IL18BP Gene

    Size:
    194 amino acids
    Molecular mass:
    21099 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD17187.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17189.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAD17190.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17192.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAF31697.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL18BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL18BP Gene

Proteomics data for IL18BP Gene at MOPED

Post-translational modifications for IL18BP Gene

  • N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser46, Thr47, Ser53, Asn79, Asn94, Asn103, and Asn147

No data available for DME Specific Peptides for IL18BP Gene

Domains for IL18BP Gene

Gene Families for IL18BP Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors

Protein Domains for IL18BP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL18BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95998

UniProtKB/Swiss-Prot:

I18BP_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • O95998
genes like me logo Genes that share domains with IL18BP: view

Function for IL18BP Gene

Molecular function for IL18BP Gene

GENATLAS Biochemistry: interleukin 18 binding protein homolog to several poxvirus proteins,expressed in the spleen inhibitor of the early Th1 cytokine response,abolishing IL18 induction of INF gamma
UniProtKB/Swiss-Prot Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Gene Ontology (GO) - Molecular Function for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042007 interleukin-18 binding IDA 10023777
GO:0048019 receptor antagonist activity TAS 11890646
genes like me logo Genes that share ontologies with IL18BP: view

miRNA for IL18BP Gene

miRTarBase miRNAs that target IL18BP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IL18BP Gene

Localization for IL18BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18BP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL18BP Gene COMPARTMENTS Subcellular localization image for IL18BP gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10023777
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IL18BP: view

Pathways for IL18BP Gene

genes like me logo Genes that share pathways with IL18BP: view

Pathways by source for IL18BP Gene

1 R&D Systems pathway for IL18BP Gene

Interacting Proteins for IL18BP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000260049%0d%0a9606.ENSP00000263326%0d%0a9606.ENSP00000280357%0d%0a
Selected Interacting proteins: ENSP00000260049 O95998-I18BP_HUMAN for IL18BP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032496 response to lipopolysaccharide IEA --
GO:0042088 T-helper 1 type immune response IDA 10023777
GO:0070301 cellular response to hydrogen peroxide IEA --
GO:0071356 cellular response to tumor necrosis factor IEA --
GO:1900116 extracellular negative regulation of signal transduction TAS 11890646
genes like me logo Genes that share ontologies with IL18BP: view

Compounds for IL18BP Gene

(3) Novoseek inferred chemical compound relationships for IL18BP Gene

Compound -log(P) Hits PubMed IDs
endotoxin 12.3 1
alanine 9.13 1
creatinine 0 3
genes like me logo Genes that share compounds with IL18BP: view

Transcripts for IL18BP Gene

Unigene Clusters for IL18BP Gene

Interleukin 18 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL18BP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: - - -
SP6:
SP7: -

Relevant External Links for IL18BP Gene

GeneLoc Exon Structure for
IL18BP
ECgene alternative splicing isoforms for
IL18BP

Expression for IL18BP Gene

mRNA expression in normal human tissues for IL18BP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL18BP Gene

SOURCE GeneReport for Unigene cluster for IL18BP Gene Hs.591967

mRNA Expression by UniProt/SwissProt for IL18BP Gene

O95998-I18BP_HUMAN
Tissue specificity: Strongly expressed in heart, lung, placenta and spleen.
genes like me logo Genes that share expressions with IL18BP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IL18BP Gene

Orthologs for IL18BP Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL18BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL18BP 35
  • 99.14 (n)
  • 98.97 (a)
IL18BP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL18BP 35
  • 80.65 (n)
  • 68.82 (a)
IL18BP 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL18BP 35
  • 75 (n)
  • 67.31 (a)
IL18BP 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il18bp 35
  • 78.02 (n)
  • 67.58 (a)
Il18bp 16
Il18bp 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL18BP 36
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il18bp 35
  • 75.09 (n)
  • 64.74 (a)
Species with no ortholog for IL18BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18BP Gene

ENSEMBL:
Gene Tree for IL18BP (if available)
TreeFam:
Gene Tree for IL18BP (if available)

Paralogs for IL18BP Gene

No data available for Paralogs for IL18BP Gene

Variants for IL18BP Gene

Sequence variations from dbSNP and Humsavar for IL18BP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs760246 -- 72,002,323(+) CTGGT(C/T)GAAAT utr-variant-3-prime
rs1062452 -- 72,001,965(+) GGATG(A/C)GCAAC utr-variant-3-prime, downstream-variant-500B
rs1573503 -- 72,000,895(-) TGACA(A/G)AGGCA intron-variant
rs1892919 -- 72,001,129(-) CCCTC(C/T)CTGCC intron-variant
rs2298455 -- 71,999,432(-) GGATC(G/T)CTAAT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IL18BP Gene

Variant ID Type Subtype PubMed ID
nsv428262 CNV Gain+Loss 18775914

Relevant External Links for IL18BP Gene

HapMap Linkage Disequilibrium report
IL18BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18BP Gene

Disorders for IL18BP Gene

(15) Novoseek inferred disease relationships for IL18BP Gene

Disease -log(P) Hits PubMed IDs
ectromelia 79.3 5
molluscum contagiosum 68.8 2
smallpox 53.8 4
cowpox 50.2 2
rheumatoid arthritis 34.3 7

Relevant External Links for IL18BP

Genetic Association Database (GAD)
IL18BP
Human Genome Epidemiology (HuGE) Navigator
IL18BP
genes like me logo Genes that share disorders with IL18BP: view

No data available for UniProtKB/Swiss-Prot for IL18BP Gene

Publications for IL18BP Gene

  1. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. (PMID: 10023777) Novick D. … Rubinstein M. (Immunity 1999) 2 3 4 23
  2. Cloning and expression of interleukin-18 binding protein. (PMID: 10094485) Aizawa Y. … Kurimoto M. (FEBS Lett. 1999) 3 4 23
  3. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. (PMID: 10655506) Kim S.-H. … Dinarello C.A. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  4. Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men. (PMID: 17951325) Thompson S.R. … Humphries S.E. (Arterioscler. Thromb. Vasc. Biol. 2007) 3 23 48
  5. Comprehensive evaluation of positional candidates in the IL-18 pathway reveals suggestive associations with schizophrenia and herpes virus seropositivity. (PMID: 18092318) Shirts B.H. … Nimgaonkar V.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23

Products for IL18BP Gene

Sources for IL18BP Gene

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