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IL18BP Gene

protein-coding   GIFtS: 55
GCID: GC11P071709

Interleukin 18 Binding Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 18 Binding Protein1 2     Interleukin-18-Binding Protein2
MC51L-53L-54L Homolog Gene Product1 2     tadekinig-alfa2
IL-18BP2 3     Tadekinig-alfa3
IL18BPa2     

External Ids:    HGNC: 59871   Entrez Gene: 100682   Ensembl: ENSG000001374967   OMIM: 6041135   UniProtKB: O959983   

Export aliases for IL18BP gene to outside databases

Previous GC identifers: GC11P074042 GC11P073248 GC11P071931 GC11P071435 GC11P071436 GC11P071387 GC11P068003


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL18BP Gene:
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18,
prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in
reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear
cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
(provided by RefSeq, Feb 2011)

GeneCards Summary for IL18BP Gene:
IL18BP (interleukin 18 binding protein) is a protein-coding gene. Diseases associated with IL18BP include smallpox, and cowpox. GO annotations related to this gene include interleukin-18 binding and receptor antagonist activity.

UniProtKB/Swiss-Prot: I18BP_HUMAN, O95998
Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine
response

Gene Wiki entry for IL18BP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL18BP gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL18BP promoter sequence
   Search Chromatin IP Primers for IL18BP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL18BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13

IL18BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL18BP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071709:  view genomic region     (about GC identifiers)

Start:
71,709,587 bp from pter      End:
71,716,761 bp from pter
Size:
7,175 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I18BP_HUMAN, O95998 (See protein sequence)
Recommended Name: Interleukin-18-binding protein precursor  
Size: 194 amino acids; 21099 Da
Sequence caution: Sequence=AAD17187.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD17188.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD17189.1;
Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAD17190.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAD17191.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAD17192.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Sequence=AAF31697.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KUZ0 B7WPK4 O95993 O96027 Q9NZA9 Q9UBR7
Alternative splicing: 3 isoforms:  O95998-2   O95998-3   O95998-4   

Explore the universe of human proteins at neXtProt for IL18BP: NX_O95998

Explore proteomics data for IL18BP at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53:
    HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor),
    dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc41
  • Glycosylation2 at Ser46, Thr47, Ser53, Asn79, Asn94, Asn103, Asn147
  • Modification sites at PhosphoSitePlus

  • See IL18BP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001034748.1  NP_001034749.1  NP_001138527.1  NP_001138529.1  NP_005690.2  NP_766630.2  NP_766632.2  

    ENSEMBL proteins: 
     ENSP00000377306   ENSP00000434717   ENSP00000377308   ENSP00000338723   ENSP00000434835  
     ENSP00000343309   ENSP00000434376   ENSP00000377310   ENSP00000384212   ENSP00000260049  

    IL18BP Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IL18BP
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    Sino Biological Cell Lysate for IL18BP
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    Cloud-Clone Corp. Proteins for IL18BP

    IL18BP Antibody Products:

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    Cloud-Clone Corp. CLIAs for IL18BP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    1 InterPro protein domain:
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry O95998

    ProtoNet protein and cluster: O95998

    UniProtKB/Swiss-Prot: I18BP_HUMAN, O95998
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    IL18BP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I18BP_HUMAN, O95998
    Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine
    response

         Genatlas biochemistry entry for IL18BP:
    interleukin 18 binding protein homolog to several poxvirus proteins,expressed in the spleen inhibitor of the early
    Th1 cytokine response,abolishing IL18 induction of INF gamma

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042007interleukin-18 binding IDA10023777
    GO:0048019receptor antagonist activity TAS11890646
         
    IL18BP for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Il18bp (no phenotypes)

    IL18BP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il18bptm1Lex for IL18BP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL18BP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL18BP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL18BP

    miRNA
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    miRTarBase miRNAs that target IL18BP:
    hsa-mir-335-5p (MIRT018976)

    Block miRNA regulation of human, mouse, rat IL18BP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL18BP (see all 10):
    hsa-miR-142-5p hsa-miR-576-5p hsa-miR-2114 hsa-miR-3166 hsa-miR-4263 hsa-miR-138-2* hsa-miR-629* hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmidIL18BP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL18BP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I18BP_HUMAN, O95998: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10023777
    GO:0005615extracellular space IEA--

    IL18BP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL18BP About    
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL18BP
        IL-1 Family Signaling Pathways




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IL18BP
    Interactions:

        GeneGlobe Interaction Network for IL18BP

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for IL18BP (O959983 ENSP000002600494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL18Q141163, ENSP000002803574I2D: score=2 STRING: ENSP00000280357
    IL37Q9NZH63, ENSP000002633264I2D: score=1 STRING: ENSP00000263326
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032496response to lipopolysaccharide IEA--
    GO:0042088T-helper 1 type immune response IDA10023777
    GO:0070301cellular response to hydrogen peroxide IEA--
    GO:0071356cellular response to tumor necrosis factor IEA--
    GO:1900116extracellular negative regulation of signal transduction TAS11890646

    IL18BP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL18BP (I18BP)

    3 Novoseek inferred chemical compound relationships for IL18BP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 12.3 1 10094485 (1)
    alanine 9.13 1 16979683 (1)
    creatinine 0 3 14640238 (1), 11890646 (1), 11226333 (1)



    IL18BP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL18BP gene (8 alternative transcripts): 
    NM_001039659.1  NM_001039660.1  NM_001145055.1  NM_001145057.1  NM_005699.3  NM_173042.2  NM_173044.2  NM_173043.1  

    Unigene Cluster for IL18BP:

    Interleukin 18 binding protein
    Hs.591967  [show with all ESTs]
    Unigene Representative Sequence: AF110801
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393703 ENST00000497194(uc001ore.1 uc001orf.1 uc021qmv.1 uc001org.1 uc001ori.2 uc001orh.2)
    ENST00000393705 ENST00000525932 ENST00000414358 ENST00000531777 ENST00000337131
    ENST00000531053 ENST00000343898(uc009ysv.1) ENST00000534583 ENST00000393707
    ENST00000404792 ENST00000260049
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IL18BP (see all 10):
    hsa-miR-142-5p hsa-miR-576-5p hsa-miR-2114 hsa-miR-3166 hsa-miR-4263 hsa-miR-138-2* hsa-miR-629* hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmidIL18BP 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat IL18BP
      QuantiFast Probe-based Assays in human, mouse, rat IL18BP

    Additional mRNA sequence: 

    AB019504.1 AF086560.1 AF110799.1 AF110800.1 AF110801.1 AF122906.1 BC044215.1 

    14 DOTS entries:

    DT.402907  DT.100881038  DT.95336437  DT.91884303  DT.100881043  DT.40132911  DT.95201570  DT.448720 
    DT.100881042  DT.92387733  DT.120712045  DT.91659804  DT.95201565  DT.100045744 

    Selected AceView cDNA sequences (see all 108):

    AF110800 BI822872 NM_173042 NM_005699 BF724662 NM_173043 BQ920140 CR606710 
    AB019504 BQ918945 BM312497 AF110799 BX357194 BU541912 CR605363 NM_173044 
    AF122906 BI824342 BC044215 AA311795 BU752555 CA433349 AK098255 AI674844 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL18BP (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                    -           -     -                                                   
    SP2:                                                                                          
    SP3:                    -     -     -     -                                                   
    SP4:                                                                                          
    SP5:                                                        -     -     -                     


    ECgene alternative splicing isoforms for IL18BP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL18BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL18BP Expression
    About this image

    IL18BP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL18BP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591967

    UniProtKB/Swiss-Prot: I18BP_HUMAN, O95998
    Tissue specificity: Strongly expressed in heart, lung, placenta and spleen

        Custom PCR Arrays for IL18BP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18BP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL18BP gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il18bp1 , 5 interleukin 18 binding protein1, 5 78.02(n)1
    67.58(a)1
      7 (54.71 cM)5
    160681  NM_010531.11  NP_034661.11 
     1020150795 


    ENSEMBL Gene Tree for IL18BP (if available)
    TreeFam Gene Tree for IL18BP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL18BP (see all 201)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57925671,2
    C--68007203(+) TTTTT-/T/TT  
            
    CCCCC
    14 -- ut31 trp31NA 2
    rs1917339411,2
    --71571933(+) AACAAA/GGGAAG 3 -- us2k10--------
    rs15413061,2
    C,F,O,A,H--71571964(-) CAAATC/TTTCAA 3 -- us2k139Minor allele frequency- G:0.00NA EA MN NS WA 5097
    rs1180060001,2
    C,F--71571972(+) TTGTTT/ATGGGA 3 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1839547251,2
    --71572026(+) GCTGTG/TGTCAG 3 -- us2k10--------
    rs764307871,2
    C--71572151(+) CCAGCG/AGTCAC 5 -- us2k14Minor allele frequency- A:0.04CSA WA NA EA 360
    rs1154323611,2
    F--71572158(+) TCACTC/TTGCCA 5 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1878989451,2
    --71572332(+) TTTTTA/GTCATT 5 -- us2k10--------
    rs1907993451,2
    --71572363(+) GACAAC/TGGGAG 5 -- us2k10--------
    rs1160124821,2
    C,F--71572406(+) GGCTTC/TTAGGA 5 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for IL18BP (71709587 - 71716761 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL18BP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428262CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL18BP
    DNA2.0 Custom Variant and Variant Library Synthesis for IL18BP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604113    OMIM disorders: --

    Selected diseases for IL18BP (see all 47):    
    About MalaCards
    smallpox    cowpox    alcoholic hepatitis    molluscum contagiosum
    crohn's disease    adenomyosis    head injury    adult-onset still's disease
    traumatic brain injury    chikungunya    acute graft versus host disease    vaccinia
    brain injury    wegener's granulomatosis    lupus nephritis    lipodystrophy
    graft versus host disease    nephritis    purpura    thrombocytopenia


    IL18BP for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IL18BP gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ectromelia 79.3 6 10769064 (2), 15105546 (1), 15193916 (1), 19104048 (1)
    molluscum contagiosum 68.8 3 15105546 (1), 16091916 (1)
    smallpox 53.8 5 15193916 (1), 16979683 (1), 17959666 (1), 19104048 (1)
    cowpox 50.2 2 10769064 (2)
    rheumatoid arthritis 34.3 9 15188356 (2), 12626794 (1), 19225717 (1), 12632414 (1) (see all 6)
    inflammation 32.4 4 12172382 (1), 12874202 (1), 12462332 (1), 19805173 (1)
    colon carcinoma 25.9 4 19046253 (2), 10673399 (1)
    autoimmune diseases 24 1 19104048 (1)
    necrosis 7.61 2 11447182 (1)
    liver diseases 2.14 5 20422882 (3), 12462332 (1)

    Genetic Association Database (GAD): IL18BP
    Human Genome Epidemiology (HuGE) Navigator: IL18BP (8 documents)

    Export disorders for IL18BP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL18BP gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with IL18BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. (PubMed id 10023777)1, 2, 3, 9 Novick D....Rubinstein M. (Immunity 1999)
    2. Cloning and expression of interleukin-18 binding protein. (PubMed id 10094485)1, 2, 9 Aizawa Y.... Kurimoto M. (FEBS Lett. 1999)
    3. Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men. (PubMed id 17951325)1, 4, 9 Thompson S.R....Humphries S.E. (Arterioscler. Thromb. Vasc. Biol. 2007)
    4. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. (PubMed id 10655506)1, 2, 9 Kim S.-H.... Dinarello C.A. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    6. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PubMed id 16043644)1, 4 Tiret L....Blankenberg S. (Circulation 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10068 HGNC: 5987 AceView: IL18BP Ensembl:ENSG00000137496 euGenes: HUgn10068
    ECgene: IL18BP H-InvDB: IL18BP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL18BP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL18BP gene:
    Search GeneIP for patents involving IL18BP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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